WO2000064532A1 - Cancer electrochemical-therapeutic device using electrothermal needles - Google Patents

Cancer electrochemical-therapeutic device using electrothermal needles Download PDF

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Publication number
WO2000064532A1
WO2000064532A1 PCT/CN2000/000073 CN0000073W WO0064532A1 WO 2000064532 A1 WO2000064532 A1 WO 2000064532A1 CN 0000073 W CN0000073 W CN 0000073W WO 0064532 A1 WO0064532 A1 WO 0064532A1
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Prior art keywords
needle
heating
electrochemical
electric heating
power source
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PCT/CN2000/000073
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English (en)
French (fr)
Inventor
Caijun Sun
Original Assignee
Caijun Sun
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Publication date
Application filed by Caijun Sun filed Critical Caijun Sun
Priority to JP2000613519A priority Critical patent/JP4124970B2/ja
Priority to AU36537/00A priority patent/AU3653700A/en
Priority to EP00915096.2A priority patent/EP1188458B1/en
Publication of WO2000064532A1 publication Critical patent/WO2000064532A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents

Definitions

  • the present invention relates to a device for treating tumors with electrothermal needle and electrothermal needle as electrodes, and belongs to a medical device.
  • Electrothermal acupuncture and electrochemical technology have been used for tumor treatment for more than ten years. They both use the current generated after the power is turned on. The first is to act on the heating body in the hollow body of the electrothermal acupuncture to generate heat and insert it.
  • the tissue of the tumor foci plays a thermal role; the second is that it acts on two positive and negative electrodes inserted in the tumor foci, causing electrode reactions and electrode side reactions between the yin and yang electrodes, and strong acid and alkaline killing between the two electrodes, respectively.
  • Area to achieve the effect of electrochemotherapy are not used in the clinic, the temperature of the treatment of tumor lesions by electrothermal acupuncture alone is difficult to control, especially for larger diameter tumor tissues.
  • electrochemical treatment alone can kill tumor cells, it also has problems such as unevenness and even synchronization.
  • the purpose of the present invention is to overcome the above-mentioned shortcomings, and to provide a synergy, complementarity, and synergy of electrothermal acupuncture and electrochemical therapy technologies in the physical, chemical, and physiological action mechanisms.
  • a thermal needle electrochemical tumor treatment device which is effectively combined into one body.
  • the object of the present invention is achieved by the following technical scheme, which is composed of at least two groups, each group has at least one electric heating needle with a heating element inside, and three DC power sources, of which two DC power sources are heating power sources. They are respectively It is connected to the heating elements in the two groups of electric heating needles; the other DC power source is an electrochemical power source, and its two poles are respectively connected to the corresponding electrodes of the two heating power sources.
  • the electric heating needle according to the present invention comprises a group of central electric heating needles composed of at least one electric heating needle and a group of peripheral electric heating needles composed of at least two electric heating needles.
  • the central electric heating needle has a heating power source and an electrode (such as a positive electrode) connected with
  • the electrochemical power source is on the same electrode (such as the positive electrode), and the other corresponding electrode (such as the negative electrode) of the heating power source of the surrounding electrothermal needle is next to the electrochemical power source on the same electrode (such as the negative electrode).
  • the heating power source and the electrochemical power source are both floating DC constant current adjustable power sources, wherein the magnitude of the electrochemical current is adjusted by the electrochemical power source, and the heating temperature of the electrothermal needle is adjusted by the heating power source.
  • the electric heating needle according to the present invention is a stainless steel hollow needle body, which is provided with a nickel-chromium wire heating element, and the outer periphery of the central electric heating needle is covered with platinum.
  • the invention is also provided with a temperature measuring needle.
  • the temperature measuring needle is constructed by insulating a temperature measuring thermal sensor in a hollow stainless steel needle body, and is insulated from the temperature measuring needle.
  • a temperature indicator is connected with the temperature measuring thermal sensor.
  • FIG. 1 is a schematic structural diagram of the present invention.
  • FIG. 2 is a schematic structural diagram of an electric heating needle according to the present invention.
  • the electric heating needle structure of the present invention includes a stainless steel hollow needle body 1, the front end of the needle body 1 has a pointed needle head 2, and a nickel-chromium wire
  • One end of the heating element 3 is fixedly connected to the pointed needle head 2, and the other end is connected to one end of the power source.
  • the other end of the power supply is connected to the needle body 1 to form a current loop. After the current flows through the heating body 3, heat is generated. Since the structure of the above-mentioned electrothermal needle has been disclosed in the Chinese Patent Gazette as a well-known technology, it will not be described in detail here. As shown in FIG.
  • this embodiment is mainly composed of five electric heating pins 4 provided with heating elements 3 and three DC constant current adjustable power supplies 5 floating independently of each other.
  • the electric heating needle 4 is divided into two groups, one is composed of a central electric heating needle 41, and the other is composed of four electric heating needles.
  • the two electric power sources in the power source 5 are heating power sources 51, one of which is heating.
  • the two poles of the power source 511 are connected to the central electric heating pin 41, and the two poles of the other heating power source 512 are connected to the four peripheral electric heating pins 42 in parallel;
  • the other power source in the power source 5 is an electrochemical power source 52, and its positive electrode is connected to the heater
  • the positive electrode of the power source 511 is connected to the negative electrode of the heating electrode 512.
  • the positive and negative connections of the above-mentioned electrochemical power source may be opposite to the above, that is, the positive electrode is connected to the positive electrode of the heating power source 512, and the negative electrode is connected to the negative plate of the heating element 511.
  • a switch K and a current regulator 6 are also provided.
  • the temperature of the electric needle can be controlled by adjusting the heating current, and the magnitude of the electrochemical current I can also be obtained by adjusting the current regulator 6.
  • turning on the heating power source 51 can cause the central electric needle 41 and the peripheral electric needle 42 to generate heat and produce a thermal effect on the tumor.
  • the chemical power supply 52 When the chemical power supply 52 is turned on separately, at this time, a current is generated between the central heating needle 41 and the surrounding heating needle 42, that is, an electrochemotherapy effect is generated between the heating needle 4, which causes a chemical change in the tumor tissue, that is, one end of the heating needle With the other end of the electrothermal needle, a strong reduction and strong alkali area are generated. And when the heating power source 51 and the electrochemical power source 52 are turned on at the same time, the electrothermal effect and electrochemotherapy effect that occur on the two at the same time should act on the tumor tissue at the same time, and they can strengthen the killing effect on the tumor tissue.
  • the structure of the central electric heating needle 41 according to the present invention is substantially similar to the surrounding electric heating needle 42, but in order to avoid the corrosive effect in the electrochemical process, the outer periphery is covered with platinum 7.
  • the present invention is also provided with a temperature measuring needle 8, which is a temperature measuring sensor that is installed in a hollow stainless steel needle body and is insulated from the temperature measuring needle.
  • a temperature indicator 9 is connected to the temperature measuring heat sensor.
  • the center heating needle 41 according to the present invention may also be replaced by an electrode needle, and this electrode needle may be made of platinum wire.
  • Another embodiment of the present invention further includes a central electric heating needle 41 composed of two or more electric heating needles 4 and a peripheral electric heating needle 42 composed of three or more electric heating needles 4.
  • the power source 5 may also be composed of several heating power sources 51 to form a heating power source group, or several electrochemical power sources 52 to form an electrochemical power source group.
  • the present invention mainly uses the heating element 3 in the electric heating needle 4 to generate electricity and generate electric curative effect.
  • the two electric heating needles 4 are used as the positive and negative poles of the power source to generate electric current, thereby generating an electrochemotherapy effect in tumor tissue.
  • the present invention uses a group of internally heated electrothermal needles as one electrode, it is inserted into the tumor tissue from the periphery of the tumor focus, and a platinum-coated electrothermal needle is inserted into the center of the tumor focus as the other electrode.
  • each electric heating needle When a certain constant current is passed through each needle, each electric heating needle generates heat and functions as a thermotherapy.
  • direct current is applied to the center electrode and the peripheral electrodes, an electrode reaction and an electrode side reaction occur between the anode and the cathode with the electrode as the axis, and a strong acid and a strong magnetic killing area are generated between the electrodes. These killer substances enhance the killing effect under the action of heat.
  • the killing effect of electrochemotherapy on cells is strengthened. It can also reduce the expansion of tissue volume caused by the effect of heat and loosen cell connections The possibility of vasodilation and accelerated blood flow leading to tumor cell metastasis.
  • the therapeutic dose is reduced compared with the two alone, the course of treatment is shortened, and the patient's pain is greatly reduced.
  • the invention integrates two kinds of treatment functions into one, and the functions can be divided and combined, and the treatment effect can be increased first, and the treatment effect of the whole machine is greatly increased, but the whole machine cost is not increased.

Description

热针电化学肿瘤治疗装置 技术领域
本发明涉及一种以电热针为电极兼具电热和电化学治疗肿瘤的装置， 属于一 种医疗器械。
背景技术
电热针和电化学技术分别用于肿瘤治疗已有十几年的历史了， 它们均利用电 源接通后产生的电流， 一是作用于电热针中空体内的发热体， 使之产生热量并对 插入的肿瘤灶体组织起热作用； 二是作用于两插入在肿瘤灶体上的正负电极， 使 阴、 阳两极间产生电极反应和电极副反应， 在两极间分别产生强酸和强碱性杀伤 区， 达到电化疗的效果。 但由于这两种肿瘤治疗技术均分别不用地应用在临床上， 因此， 单独的电热针治疗肿瘤病灶， 其治疗的温度较难得到控制， 特别是对较大 直径的肿瘤组织升温不能均匀。 同时单独的电化学治疗虽也能杀伤肿瘤细胞， 但 它也存在不均匀， 甚至不能同步等问题。
发明内容
本发明的目的在于克服上述存在的不足， 提供一种旨在利用电热针和电化学 治疗技术在物理学、 化学和生理学作用机制上的协同性、 互补性和增效性等特点， 将两者有效地结合为一体从而构成的热针电化学肿瘤治疗装置。
本发明的目的是通过如下技术方案来完成的， 它至少由二组、 每组至少有一 根内设置有发热体的电热针、三个直流电源组成，其中两个直流电源为加热电源.它 们分别与两组电热针内的发热体相连； 另一个直流电源为电化学电源， 其二极分 别与二个加热电源的相应电极相接。
本发明所述的电热针包括一组至少由一根电热针组成的中心电热针和一组至 少由二根电热针组成的周边电热针， 中心电热针有加热电源一电极（如正极）接有 电化学电源相同电极（如正极)上，而周边电热针的加热电源另一对应电极（如负极） 接着电化学电源另一相同电极 (如负极)上。
所述的加热电源和电化学电源均为浮空的直流恒流可调电源， 其中电化学电 流的量值由电化学电源调节， 电热针的加热温度由加热电源调节。 本发明所述的电热针为不锈钢空心针体， 其内设置有镍铬丝发热体， 且所述 的中心电热针的外周包复有铂金。
本发明还配套设置有测温针， 该测温针是将测温热传感器装入于空心不锈钢 针体内并与之绝缘构成， 与测温热传感器相连接出有温度指示器。
附图的简要说明
图 1是本发明的结构示意图。
图 2是本发明的电热针结构示意图。
实现本发明的最佳方式
下面将通过附图对本发明作详细的介绍： 图 2所示， 本发明的电热针结构包 括一不锈钢空心针体 1， 针体 1的前端部有一尖的针头部 2， 一由镍铬丝组成的发 热体 3， 其一端固连在尖的针头部 2 上， 另一端接着电源的一极端。 而电源的另 一极端接于针体 1上， 使之形成一电流回路， 电流流过发热体 3后即会产生热量。 由于上述电热针的结构已作为公知技术在中国专利公报上已有公开， 故在此不再 作详细的介绍。 图 1所示， 本实施例主要由五根内设置有发热体 3 的电热针 4、 及三个彼此独立浮空的直流恒流可调电源 5组成。 电热针 4分为两组， 一组由一 根电热针组成中心电热针 41， 另一组由四根电热针组成周边电热针 42; 电源 5中 的两个电源为加热电源 51， 其中一个加热电源 511的两极接于中心电热针 41上， 另一个加热电源 512的两极则并接在四根周边电热针 42上； 电源 5中的另一个电 源为电化学电源 52， 它的正极接于加热电源 511 的正极上， 而它的负极则接于加 热电极 512 的负极上。 本发明在其它实施例中， 上述电化学电源的正负极连接则 可与上述相反， 即其正极接于加热电源 512的正极上， 负极接于加热电原 511 的 负板上。 在以上所述的电源 5 回路中， 还各设置有开关 K和电流调节器 6， 通过 调节加热电流可控制电热针的温度， 而电化学电流 I 的量值也可用电流调节器 6 调节获得。 使用时， 接通加热电源 51， 可以使中心电热针 41和周边电热针 42产 生热量， 并对肿瘤产生热效应。 当单独接通化学电源 52， 这时， 中心电热针 41 和周边电热针 42之间产生电流， 也即电热针 4之间产生电化疗效应， 它使肿瘤组 织起化学变化， 即电热针的一端与电热针的另一端产生强减与强碱区域。 而同时 接通加热电源 51 和电化学电源 52， 这时两者所发生的电热疗效应和电化疗效应 同时作用于肿瘤组织， 并且它们能加强对肿瘤组织的杀伤作用。 本发明所述的中心电热针 41结构与周边电热针 42大致相似， 但为了避免电 化学过程中的腐蚀作用， 在其外周包以铂金 7。
本发明还配套设置有测温针 8， 该测温针 8 是将测温传感器装入于空心不锈 钢针体内并与之绝缘构成， 与该测温热传感器相连接出有温度指示器 9。
本发明所述的中心电热针 41 也可用电极针代替， 这种电极针可用铂金丝制 作而成。
本发明的另外实施例还包括由二根或多根电热针 4 组成的中心电热针 41 以 及由三根或多根电热 4组成的周边电热针 42。 所述的电源 5也可由几个加热电源 51 组成加热电源组， 或由几个电化学电源 52 组成电化学电源组。 本发明主要是 利用电热针 4内的发热体 3通电发热使之产生电热疗效应， 利用两根电热针 4作 为电源的正负两极， 使之产生电流， 从而在肿瘤组织中产生电化疗效应。
由于本发明以一组内热的电热针为一电极， 从肿瘤灶的外围插入肿瘤组织 中， 一根包以铂金的电热针为另一电极插人肿瘤灶的中心。 当每根针通以一定的 恒流电流时各电热针分别发热而起热疗作用。 当中心电极和周边电极通以直流电 流时， 则在以电极为轴心的阴、 阳两极间产生电极反应和电极副反应， 在两极间 分别产生强酸和强磁性杀伤区。 这些杀伤物质在热的作用下使杀伤作用增强。 根 据化学动力学定律， 化学反应系统的温度每增高 10°C， 其反应速度增加 2— 3倍， 因此可使疗效大为增加。 加之阳极区内形成的酸 (HCL PH2— 3)和阴极区形成的碱 (为 NaOH PH12― 13)的增溶作用可使细胞间间隙和沟道扩大和增加， 这些作用都 能使电热针的电极处产生的热和杀伤物质迅速从其附近扩散开去， 从而可大大改 善电化疗和电热针二者分别应用时发生的治疗不均匀性。 另外二者联合后， 电化 疗对细胞的杀伤作用及对血液的血凝作用和对血管的收缩作用有所加强， 还可以 减少由于热的作用而导致的组织体积膨涨， 细胞连接变松， 血管扩张， 血流加快 而导致肿瘤细胞转移的可能性。 最后， 治疗剂量比二者单独应用时减小， 疗程缩 短， 患者痛苦也大为减轻。 本发明将两种治疗功能集于一身， 且其功能可分可合， 可先可后， 整机的治疗效果大大增加， 而整机成本却并未增加。

Claims

权 利 要 求 书
1、 一种热针电化学肿瘤治疗装置， 其特征在于它至少由二组、 每组至少有 一根内设置有发热体 (3)的电热针 (4)和三个直流电源 (5)组成， 其中两个直流电源 为加热电源 (51)， 它们分别与二组电热针内的发热体 (3)相接， 另一个直流电源为 电化学电源 (52)， 其两极分别与两个加热电源 (51)相应的电极相接。
2、 如权利要求 1 所述的热针电化学肿瘤治疗装置， 其特征在于所述的电热 针包括一组至少由一根电热针 (4)组成的中心电热针 (41)和一组至少由二根电热针 (4)组成的周边电热针 (42)， 中心电热针 (41)的加热电源 (511)的一电极接着电化 学电源 (52)相同电极上， 而周边电热针 (42)的加热电源 (512)的另一对应电极接着 电化学电源 (52)另一相同电极上。
3、 如权利要求 2 所述的热针电化学肿瘤治疗装置， 其特征在于所述的加热 电源 (51)和电化学电源（52)均为浮空的直流恒流可调电源， 其中电化学电流的量 值由电化学电源调节， 电热针的加热温度由加热电源调节。
4、 如权利要求 1或 2或 3所述的热针电化学肿瘤治疗装置， 其特征在于所 述的电热针 (4)为不锈钢空心针体， 其内设置有镍铬丝发热体 (3)， 且所述的中心 电热针 (41)的外周包复有铂金 (7)。
5、 如权利要求 4 所述的热计电化学肿瘤治疗装置， 其特征在于所述的与电 热针 (4)配套有测温针 (8)， 该测温针 (8)是将测温热传感器装入于空心不锈钢针体 内并与之绝缘构成， 与测温热传感器相连接出有温度指示器 (9)。
PCT/CN2000/000073 1999-04-23 2000-04-03 Cancer electrochemical-therapeutic device using electrothermal needles WO2000064532A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000613519A JP4124970B2 (ja) 1999-04-23 2000-04-03 電熱針を電極とした電気化学法による腫瘍治療装置
AU36537/00A AU3653700A (en) 1999-04-23 2000-04-03 Cancer electrochemical-therapeutic device using electrothermal needles
EP00915096.2A EP1188458B1 (en) 1999-04-23 2000-04-03 Cancer electrochemical-therapeutic device using electrothermal needles

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CN99104583A CN1068525C (zh) 1999-04-23 1999-04-23 热针电化学肿瘤治疗装置
CN99104583.1 1999-04-23

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US (1) US6712840B2 (zh)
EP (1) EP1188458B1 (zh)
JP (1) JP4124970B2 (zh)
CN (1) CN1068525C (zh)
AU (1) AU3653700A (zh)
WO (1) WO2000064532A1 (zh)

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JP2002541995A (ja) 2002-12-10
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US20030125784A1 (en) 2003-07-03
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EP1188458B1 (en) 2015-07-08
CN1068525C (zh) 2001-07-18
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