WO2000061585A3 - 1,3-dipolar cycloadditions to polypyrrolic macrocycles - Google Patents

1,3-dipolar cycloadditions to polypyrrolic macrocycles

Info

Publication number
WO2000061585A3
WO2000061585A3 PCT/IB2000/000615 IB0000615W WO0061585A3 WO 2000061585 A3 WO2000061585 A3 WO 2000061585A3 IB 0000615 W IB0000615 W IB 0000615W WO 0061585 A3 WO0061585 A3 WO 0061585A3
Authority
WO
WIPO (PCT)
Prior art keywords
dipolar cycloadditions
polypyrrolic macrocycles
polypyrrolic
macrocycles
methods
Prior art date
Application number
PCT/IB2000/000615
Other languages
French (fr)
Other versions
WO2000061585A2 (en
Inventor
Jill Macalpine
David Dolphin
Ethan D Sternberg
Original Assignee
Univ British Columbia Ubc
Jill Macalpine
David Dolphin
Ethan D Sternberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia Ubc, Jill Macalpine, David Dolphin, Ethan D Sternberg filed Critical Univ British Columbia Ubc
Priority to AU41396/00A priority Critical patent/AU4139600A/en
Publication of WO2000061585A2 publication Critical patent/WO2000061585A2/en
Publication of WO2000061585A3 publication Critical patent/WO2000061585A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition is described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.
PCT/IB2000/000615 1999-04-14 2000-04-14 1,3-dipolar cycloadditions to polypyrrolic macrocycles WO2000061585A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41396/00A AU4139600A (en) 1999-04-14 2000-04-14 1,3-dipolar cycloadditions to polypyrrolic macrocycles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12932499P 1999-04-14 1999-04-14
US60/129,324 1999-04-14

Publications (2)

Publication Number Publication Date
WO2000061585A2 WO2000061585A2 (en) 2000-10-19
WO2000061585A3 true WO2000061585A3 (en) 2001-02-01

Family

ID=22439443

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CA2000/000435 WO2000061584A1 (en) 1999-04-14 2000-04-14 IMPROVED β,β,-DIHYDROXY MESO-SUBSTITUTED CHLORINS, ISOBACTERIOCHLORINS, AND BACTERIOCHLORINS
PCT/IB2000/000615 WO2000061585A2 (en) 1999-04-14 2000-04-14 1,3-dipolar cycloadditions to polypyrrolic macrocycles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000435 WO2000061584A1 (en) 1999-04-14 2000-04-14 IMPROVED β,β,-DIHYDROXY MESO-SUBSTITUTED CHLORINS, ISOBACTERIOCHLORINS, AND BACTERIOCHLORINS

Country Status (3)

Country Link
US (2) US6620929B1 (en)
AU (2) AU4278400A (en)
WO (2) WO2000061584A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125829B2 (en) 2012-08-17 2015-09-08 Hallstar Innovations Corp. Method of photostabilizing UV absorbers, particularly dibenzyolmethane derivatives, e.g., Avobenzone, with cyano-containing fused tricyclic compounds
US9145383B2 (en) 2012-08-10 2015-09-29 Hallstar Innovations Corp. Compositions, apparatus, systems, and methods for resolving electronic excited states

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AU2412800A (en) 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
AU4278400A (en) * 1999-04-14 2000-11-14 University Of British Columbia, The Improved beta,beta,-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
CA2408323C (en) * 2000-05-08 2012-06-12 The University Of British Columbia Drug delivery systems for photodynamic therapy
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
GB0121023D0 (en) * 2001-08-30 2001-10-24 Norwegian Radium Hospital Res Compound
SE0104334D0 (en) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
GB0229931D0 (en) 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0314079D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
PT102721B (en) * 2002-02-01 2011-01-24 Cipan Companhia Industr Prod De Antibioticos S A TETRAPYROLYLIC MACROCYCLIC COMPOUNDS WITH QUANTUM PERFORMANCE OF SINGULIUM OXYGEN SUITABLE FOR PHOTODYNAMIC THERAPY AND PROCESSES FOR THEIR PREPARATION
EP1517684B1 (en) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7518624B2 (en) * 2005-01-21 2009-04-14 Dell Products L.P. System and method for modular display
DE102005027589B3 (en) * 2005-06-14 2007-06-14 Heraeus Kulzer Gmbh Temperature / radiation / Polymerisationsindikatoren
US20090318370A1 (en) * 2007-02-19 2009-12-24 Rei Medical Co., Ltd. Novel glycoconjugated chlorin derivatives and method of producing the same
PT3459955T (en) 2008-09-18 2022-11-29 Biolitec Unternehmensberatungs Ii Ag Novel method and application of unsymmetrically meso-substituted porphyrins and chlorins for pdt
US9211283B2 (en) 2009-12-11 2015-12-15 Biolitec Pharma Marketing Ltd Nanoparticle carrier systems based on human serum albumin for photodynamic therapy
WO2014025370A1 (en) * 2012-08-10 2014-02-13 Hallstar Innovations Corp. Tricyclic energy quencher compounds for reducing singlet oxygen generation
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
US10456375B2 (en) 2014-09-30 2019-10-29 Biolitec Unternehmensbeteiligungs Ii Ag Specifically meso-substituted porphyrins and chlorins for photodynamic therapy
EP3894421A1 (en) 2018-12-10 2021-10-20 Universität Hamburg Specifically glyco-substituted porphyrins and chlorins for photodynamic therapy
CN110302177B (en) * 2019-07-05 2022-01-25 南京邮电大学 Mitochondrion targeting photo-diagnosis nano-particle and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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US5283255A (en) 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US5171749A (en) 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US4883790A (en) 1987-01-20 1989-11-28 University Of British Columbia Wavelength-specific cytotoxic agents
US5095030A (en) 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
US5726304A (en) 1992-10-30 1998-03-10 The University Of British Columbia Porphocyanine and CNC-expanded porphyrins
FR2722625B1 (en) * 1994-07-18 1996-10-04 Thomson Consumer Electronics MULTI-COMPARISON A / D CONVERTER USING THE INTERPOLATION PRINCIPLE
US5648485A (en) 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
WO1998050386A1 (en) 1997-05-07 1998-11-12 The University Of British Columbia A new class of benzoporphyrin derivative photoactive compounds
AU4278400A (en) * 1999-04-14 2000-11-14 University Of British Columbia, The Improved beta,beta,-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FAUSTINO M A F ET AL: "Diels-Alder Reactions of Ni(II) beta-Vinyl-meso-Tetraarylporphyrins", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 37, no. 20, 13 May 1996 (1996-05-13), pages 3569 - 3570, XP004029348, ISSN: 0040-4039 *
SISEMORE, MARLENE F. ET AL: "Metalloporphyrin Peroxo Complexes of Iron(III), Manganese(III), and Titanium(IV). Comparative Studies Demonstrating that the Iron(III) Complex Is Extremely Nucleophilic", INORG. CHEM. (1997), 36(6), 979-984, XP000952817 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145383B2 (en) 2012-08-10 2015-09-29 Hallstar Innovations Corp. Compositions, apparatus, systems, and methods for resolving electronic excited states
US9125829B2 (en) 2012-08-17 2015-09-08 Hallstar Innovations Corp. Method of photostabilizing UV absorbers, particularly dibenzyolmethane derivatives, e.g., Avobenzone, with cyano-containing fused tricyclic compounds

Also Published As

Publication number Publication date
AU4278400A (en) 2000-11-14
AU4139600A (en) 2000-11-14
WO2000061584A1 (en) 2000-10-19
WO2000061585A2 (en) 2000-10-19
US20040019201A1 (en) 2004-01-29
US6825343B2 (en) 2004-11-30
US6620929B1 (en) 2003-09-16

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