WO2000056354A3 - Methods of using agents that act on the epithelial sheet of a human eye - Google Patents

Methods of using agents that act on the epithelial sheet of a human eye Download PDF

Info

Publication number
WO2000056354A3
WO2000056354A3 PCT/US2000/007253 US0007253W WO0056354A3 WO 2000056354 A3 WO2000056354 A3 WO 2000056354A3 US 0007253 W US0007253 W US 0007253W WO 0056354 A3 WO0056354 A3 WO 0056354A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelial sheet
human eye
loosening
cornea
agents
Prior art date
Application number
PCT/US2000/007253
Other languages
French (fr)
Other versions
WO2000056354A2 (en
Inventor
David M D Miller
Original Assignee
Boston Innovative Optics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Innovative Optics Inc filed Critical Boston Innovative Optics Inc
Publication of WO2000056354A2 publication Critical patent/WO2000056354A2/en
Publication of WO2000056354A3 publication Critical patent/WO2000056354A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase

Abstract

A method of delaminating the epithelial sheet of the cornea of a human eye comprising loosening the epithelial sheet with a loosening solution, the loosening solution including an agent, and separating the loosened epithelial sheet from the underlying tissue of the cornea. In the alternative, a method of delaminating the epithelial sheet from the cornea of a human eye comprising making an incision in the epithelial sheet, loosening the incised epithelial sheet using a loosening solution, the loosening solution including an agent, and separating the loosened epithelial sheet from the underlying tissue of the cornea. In addition, a method of administering a medicine through the epithelial sheet of the cornea of a human eye comprising applying a treatment solution of the medicine to the eye, the treatment solution including an agent.
PCT/US2000/007253 1999-03-22 2000-03-17 Methods of using agents that act on the epithelial sheet of a human eye WO2000056354A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12538799P 1999-03-22 1999-03-22
US60/125,387 1999-03-22

Publications (2)

Publication Number Publication Date
WO2000056354A2 WO2000056354A2 (en) 2000-09-28
WO2000056354A3 true WO2000056354A3 (en) 2000-12-28

Family

ID=22419482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/007253 WO2000056354A2 (en) 1999-03-22 2000-03-17 Methods of using agents that act on the epithelial sheet of a human eye

Country Status (2)

Country Link
US (1) US6335006B1 (en)
WO (1) WO2000056354A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173790A2 (en) * 1999-03-01 2002-01-23 Boston Innovative Optics, Inc. System and method for increasing the depth of focus of the human eye
CA2454662A1 (en) * 2001-07-23 2003-02-06 Fos Holding S.A. Device for separating the epithelium layer from the surface of the cornea of an eye
US7156859B2 (en) * 2001-07-23 2007-01-02 Fos Holding S.A. Device for separating the epithelium layer from the surface of the cornea of an eye
US20070265650A1 (en) * 2001-07-23 2007-11-15 Ioannis Pallikaris Device for separating the epithelial layer from the surface of the cornea of an eye
US7153316B1 (en) * 2001-11-09 2006-12-26 Mcdonald Marguerite B Surgical instruments and method for corneal reformation
US7015039B1 (en) * 2002-08-08 2006-03-21 Massachusetts Eye & Ear Infirmary Separating epithelium from stroma in LASEK surgery
CA2498717A1 (en) * 2002-09-13 2004-03-25 Ocular Sciences, Inc. Devices and methods for improving vision
EP1569586A1 (en) * 2002-12-10 2005-09-07 Sightrate B.V. Disposable separator for separating the epithelium layer from the cornea of an eye
US20040260321A1 (en) * 2002-12-19 2004-12-23 Ming-Kok Tai Apparatus and method for separating the epithelium layer from the cornea of an eye without corneal pre-applanation
US20040188872A1 (en) * 2003-03-31 2004-09-30 Jani Dharmendra M. Method for fabricating intraocular lens with peripheral sharp edge
US7628810B2 (en) * 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
US20050046794A1 (en) * 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
WO2005023159A1 (en) * 2003-09-05 2005-03-17 Sightrate B.V. Device for separation of corneal epithelium
MXPA03011987A (en) 2003-12-19 2005-06-23 Osio Sancho Alberto Method for treating presbyopia by inducing changes in the corneal power and physiology.
WO2006015490A1 (en) * 2004-08-13 2006-02-16 Ottawa Health Research Institute Ophthalmic devices and related methods and compositions
US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
TW200740416A (en) * 2006-02-08 2007-11-01 Coopervision Inc Corneal onlays and related methods
US7883520B2 (en) * 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US20100087920A1 (en) * 2008-10-07 2010-04-08 Forsight Labs, Llc Corneal Onlay Lenses and Related Methods for Improving Vision of Presbyopic Patients
KR101796801B1 (en) * 2009-08-13 2017-11-10 아큐포커스, 인크. Masked intraocular implants and lenses
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask
JP6046160B2 (en) 2011-12-02 2016-12-14 アキュフォーカス・インコーポレーテッド Ophthalmic mask with selective spectral transmission
SG11201500994SA (en) 2012-08-10 2015-03-30 Osio Corp D B A Yolia Health Contact lens use in the treatment of an ophthalmologic condition
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016070A1 (en) * 1990-04-16 1991-10-31 Bethesda Eye Institute Enzymatic disinsertion of vitreous body
US5626865A (en) * 1991-10-15 1997-05-06 Advanced Corneal Systems, Inc. Enzyme-orthokeratology
WO1998052602A1 (en) * 1997-05-22 1998-11-26 Advanced Corneal Systems, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
WO1999040933A1 (en) * 1998-02-17 1999-08-19 The Schepens Eye Research Institute, Inc. Use of hyaluronidase to reduce viscoelastic related increases in intraocular pressure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5788957A (en) 1991-10-15 1998-08-04 Advanced Corneal Systems, Inc. Enzyme-orthokeratology
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016070A1 (en) * 1990-04-16 1991-10-31 Bethesda Eye Institute Enzymatic disinsertion of vitreous body
US5626865A (en) * 1991-10-15 1997-05-06 Advanced Corneal Systems, Inc. Enzyme-orthokeratology
WO1998052602A1 (en) * 1997-05-22 1998-11-26 Advanced Corneal Systems, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
WO1999040933A1 (en) * 1998-02-17 1999-08-19 The Schepens Eye Research Institute, Inc. Use of hyaluronidase to reduce viscoelastic related increases in intraocular pressure

Also Published As

Publication number Publication date
WO2000056354A2 (en) 2000-09-28
US6335006B1 (en) 2002-01-01

Similar Documents

Publication Publication Date Title
WO2000056354A3 (en) Methods of using agents that act on the epithelial sheet of a human eye
WO2006014484A3 (en) Methods and devices for the treatment of ocular conditions
WO2005097219A3 (en) Ecm-based graft material
WO2005034763A8 (en) Devices, systems, and methods for suturing tissue
EP2087892A3 (en) (S,S) reboxetine for treating age associated learning and mental disorders
HK1074577A1 (en) The use of thymosin ß4 (Tß4), analogues, isoforms and other derivatives in the manufacture of a medicament for treating disorders of eye and the surrounding tissue
WO2003032815A3 (en) Medical device for delivering patches
WO2001012122A3 (en) Method and system for treating cardiac arrest using hypothermia
WO2004078025A3 (en) Vascular assist device and methods
PL312219A1 (en) Application of nona- and decapeptides in obtaining a therapeutic agent for fighting against aids
WO2005001080A3 (en) Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
WO2005018549A3 (en) Methods and compositions for tissue repair
WO2003092584A3 (en) Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (ctgf) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
WO2005042051A3 (en) Method for transdermal delivery of permeant substances
CA2294921A1 (en) Levobupivacaine and its use
WO2000018316A3 (en) Sustained release, and comfortable ophthalmic composition and method for ocular therapy
AU6391000A (en) Method of preventing the injury or death of retinal cells and treating ocular diseases
WO1998039293A3 (en) 13-thia prostaglandins for use in glaucoma therapy
WO2002060410A3 (en) Methods for sustained release local delivery of drugs for ablation of unwanted tissue
RU94039513A (en) Method for treatment of retinal detachment complicated with subretinal schwart formation
WO2004010934A3 (en) Methods for the use of neurotoxin in the treatment of urologic disorders
CA2414586A1 (en) Agent for therapeutic treatment of optic nerve diseases and the like
WO2004038460A3 (en) Aqueous ophthalmic spray and method for delivery
WO2003092669A3 (en) Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac
ATE336987T1 (en) GEL PREPARATION CONTAINING A DISSOLVED OR SUSPENDED ACTIVE INGREDIENT, IN PARTICULAR FOR USE ON A MUCOUS SKIN AND PRODUCTION METHOD

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase