WO2000045856A3 - Novel methods of imaging and treatment with targeted compositions - Google Patents

Novel methods of imaging and treatment with targeted compositions Download PDF

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Publication number
WO2000045856A3
WO2000045856A3 PCT/US2000/002620 US0002620W WO0045856A3 WO 2000045856 A3 WO2000045856 A3 WO 2000045856A3 US 0002620 W US0002620 W US 0002620W WO 0045856 A3 WO0045856 A3 WO 0045856A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
patient
vesicles
ultrasound
targeted
Prior art date
Application number
PCT/US2000/002620
Other languages
French (fr)
Other versions
WO2000045856A2 (en
Inventor
Evan C Ungr
Yunqiu Wu
Original Assignee
Imarx Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imarx Pharmaceutical Corp filed Critical Imarx Pharmaceutical Corp
Priority to AU35866/00A priority Critical patent/AU777304B2/en
Priority to EP00914480A priority patent/EP1146911A2/en
Priority to CA002362200A priority patent/CA2362200A1/en
Publication of WO2000045856A2 publication Critical patent/WO2000045856A2/en
Publication of WO2000045856A3 publication Critical patent/WO2000045856A3/en
Priority to AU2005200059A priority patent/AU2005200059A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissus, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
PCT/US2000/002620 1999-02-03 2000-02-02 Novel methods of imaging and treatment with targeted compositions WO2000045856A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU35866/00A AU777304B2 (en) 1999-02-03 2000-02-02 Novel methods of imaging and treatment with targeted compositions
EP00914480A EP1146911A2 (en) 1999-02-03 2000-02-02 Novel methods of imaging and treatment with targeted compositions
CA002362200A CA2362200A1 (en) 1999-02-03 2000-02-02 Novel methods of imaging and treatment with targeted compositions
AU2005200059A AU2005200059A1 (en) 1999-02-03 2005-01-07 Novel methods of imaging and treatment with targeted compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/243,640 1999-02-03
US09/243,640 US6521211B1 (en) 1995-06-07 1999-02-03 Methods of imaging and treatment with targeted compositions

Publications (2)

Publication Number Publication Date
WO2000045856A2 WO2000045856A2 (en) 2000-08-10
WO2000045856A3 true WO2000045856A3 (en) 2001-02-15

Family

ID=22919542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002620 WO2000045856A2 (en) 1999-02-03 2000-02-02 Novel methods of imaging and treatment with targeted compositions

Country Status (5)

Country Link
US (2) US6521211B1 (en)
EP (1) EP1146911A2 (en)
AU (2) AU777304B2 (en)
CA (1) CA2362200A1 (en)
WO (1) WO2000045856A2 (en)

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