WO2000032174A3 - Pharmaceutical combination preparations of carvedilol and hydrochlorothiazide - Google Patents

Pharmaceutical combination preparations of carvedilol and hydrochlorothiazide Download PDF

Info

Publication number
WO2000032174A3
WO2000032174A3 PCT/EP1999/008972 EP9908972W WO0032174A3 WO 2000032174 A3 WO2000032174 A3 WO 2000032174A3 EP 9908972 W EP9908972 W EP 9908972W WO 0032174 A3 WO0032174 A3 WO 0032174A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrochlorothiazide
carvedilol
pharmaceutical combination
combination preparations
acceptable salt
Prior art date
Application number
PCT/EP1999/008972
Other languages
French (fr)
Other versions
WO2000032174A2 (en
Inventor
Rudolf Heller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8233041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000032174(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to EP99957320A priority Critical patent/EP1131072B1/en
Priority to DK99957320T priority patent/DK1131072T3/en
Priority to AT99957320T priority patent/ATE238056T1/en
Priority to CA002352361A priority patent/CA2352361C/en
Priority to JP2000584870A priority patent/JP2002531395A/en
Priority to BR9915610-5A priority patent/BR9915610A/en
Priority to DE69907252T priority patent/DE69907252T2/en
Priority to AU15065/00A priority patent/AU765977B2/en
Publication of WO2000032174A2 publication Critical patent/WO2000032174A2/en
Publication of WO2000032174A3 publication Critical patent/WO2000032174A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The present invention is concerned with a pharmaceutical combination preparation for the treatment of cardiac and cardiovascular disorders such as hypertension, angina pectoris, cardiac insufficiency and illnesses associated therewith, containing the active substances carvedilol or a pharmaceutically acceptable salt thereof and hydrochlorothiazide or a pharmaceutically acceptable salt thereof as well as pharmaceutically usual additives.
PCT/EP1999/008972 1998-11-27 1999-11-20 Pharmaceutical combination preparations of carvedilol and hydrochlorothiazide WO2000032174A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP99957320A EP1131072B1 (en) 1998-11-27 1999-11-20 Pharmaceutical combination preparations in solid dosage form of carvedilol and hydrochlorothiazide
DK99957320T DK1131072T3 (en) 1998-11-27 1999-11-20 Solid pharmaceutical combination formulation with carvedilol and hydrochlorothiazide
AT99957320T ATE238056T1 (en) 1998-11-27 1999-11-20 PHARMACEUTICAL COMBINATION PREPARATIONS IN SOLID FORM CONTAINING CARVEDILOL AND HYDROCHLOROTHIAZIDE
CA002352361A CA2352361C (en) 1998-11-27 1999-11-20 Pharmaceutical combination preparations of carvedilol and hydrochlorothiazide and the process for their preparation
JP2000584870A JP2002531395A (en) 1998-11-27 1999-11-20 Pharmaceutical combination
BR9915610-5A BR9915610A (en) 1998-11-27 1999-11-20 Combined pharmaceutical preparations
DE69907252T DE69907252T2 (en) 1998-11-27 1999-11-20 PHARMACEUTICAL COMBINATION PREPARATES IN SOLID FORM CONTAINING CARVEDILOL AND HYDROCHLOROTHIAZIDE
AU15065/00A AU765977B2 (en) 1998-11-27 1999-11-20 Pharmaceutical combination preparations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122489.2 1998-11-27
EP98122489 1998-11-27

Publications (2)

Publication Number Publication Date
WO2000032174A2 WO2000032174A2 (en) 2000-06-08
WO2000032174A3 true WO2000032174A3 (en) 2000-11-16

Family

ID=8233041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008972 WO2000032174A2 (en) 1998-11-27 1999-11-20 Pharmaceutical combination preparations of carvedilol and hydrochlorothiazide

Country Status (22)

Country Link
US (3) US6403579B1 (en)
EP (1) EP1131072B1 (en)
JP (2) JP2002531395A (en)
KR (1) KR100421347B1 (en)
CN (1) CN1184971C (en)
AR (1) AR020287A1 (en)
AT (1) ATE238056T1 (en)
AU (1) AU765977B2 (en)
BR (1) BR9915610A (en)
CA (1) CA2352361C (en)
CO (1) CO5011053A1 (en)
DE (1) DE69907252T2 (en)
DK (1) DK1131072T3 (en)
ES (1) ES2195638T3 (en)
MY (1) MY121831A (en)
PE (1) PE20001302A1 (en)
PT (1) PT1131072E (en)
TR (3) TR200101470T2 (en)
TW (1) TWI228414B (en)
UY (1) UY25821A1 (en)
WO (1) WO2000032174A2 (en)
ZA (1) ZA200104280B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20001302A1 (en) * 1998-11-27 2000-11-30 Hoffmann La Roche PREPARATIONS OF A PHARMACEUTICAL COMBINATION CONTAINING CARVEDILOL AND HYDROCHLOROTHIAZIDE
EP1335707A4 (en) * 2000-10-24 2005-07-06 Smithkline Beecham Corp Novel formulations of carvedilol
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
IN191028B (en) * 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
CA2483054A1 (en) * 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
WO2004002472A1 (en) 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Carvedilol hydrobromide
CN103333099A (en) 2002-06-27 2013-10-02 史密斯克莱.比奇曼（科克）有限公司 Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
EP1610767B1 (en) 2003-03-26 2011-01-19 Egalet A/S Morphine controlled release system
EP1615888A1 (en) * 2003-04-21 2006-01-18 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
AU2003272851A1 (en) * 2003-09-26 2005-04-14 Shuyi Zhang Sustained release preparation containing hydrochlorothiazide
WO2005051383A1 (en) 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
US20050169994A1 (en) * 2003-11-25 2005-08-04 Burke Matthew D. Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
WO2005051322A2 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts
SI1691804T1 (en) * 2003-12-02 2007-10-31 Nicox Sa Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs
EP1855655A2 (en) * 2005-02-25 2007-11-21 F. Hoffmann-Roche AG Tablets with improved drug substance dispersibility
US8685452B2 (en) * 2006-06-16 2014-04-01 Lek Pharmaceuticals D.D. Pharmaceutical composition
GB0612540D0 (en) * 2006-06-23 2006-08-02 Novartis Ag Galenical formulations of organic compounds
WO2008114276A1 (en) * 2007-03-16 2008-09-25 Lupin Limited Novel oral controlled release composition of carvedilol
CA2687192C (en) 2007-06-04 2015-11-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
EP2445487A2 (en) 2009-06-24 2012-05-02 Egalet Ltd. Controlled release formulations
US20130121916A1 (en) * 2010-03-10 2013-05-16 Sergio Baroni Compositions for Colon Lavage and Methods of Making and Using Same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019398A (en) * 1989-02-27 1991-05-28 Sanofi Pharmaceutical composition providing the sustained-release of valproic acid
US5425950A (en) * 1991-10-30 1995-06-20 Glaxo Group Limited Controlled release pharmaceutical compositions
WO1996024348A2 (en) * 1995-02-08 1996-08-15 Boehringer Mannheim Pharmaceuticals Corporation Use of carbazole compounds for the treatment of congestive heart failure
WO1998005320A1 (en) * 1996-08-07 1998-02-12 Jouveinal Coated trimebutine maleate tablet
DE19637082A1 (en) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (en) 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh NEW CARBAZOLYL- (4) -OXY-PROPANOLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
GB2257363B (en) * 1991-01-30 1994-09-28 Wellcome Found Water dispersible tablets containing acyclovir
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
PE20001302A1 (en) * 1998-11-27 2000-11-30 Hoffmann La Roche PREPARATIONS OF A PHARMACEUTICAL COMBINATION CONTAINING CARVEDILOL AND HYDROCHLOROTHIAZIDE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019398A (en) * 1989-02-27 1991-05-28 Sanofi Pharmaceutical composition providing the sustained-release of valproic acid
US5425950A (en) * 1991-10-30 1995-06-20 Glaxo Group Limited Controlled release pharmaceutical compositions
WO1996024348A2 (en) * 1995-02-08 1996-08-15 Boehringer Mannheim Pharmaceuticals Corporation Use of carbazole compounds for the treatment of congestive heart failure
WO1998005320A1 (en) * 1996-08-07 1998-02-12 Jouveinal Coated trimebutine maleate tablet
DE19637082A1 (en) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Eudragit E30D Anwendung in der Arzneimittelherstellung", May 1981, RÖHM PHARMA, WEITERSTAT, XP002145397 *
BISTON P. ET AL: "Carvedilol in the treatment of mild to moderate hypertension: Experience with ambulatory blood pressure monitoring.", ACTA CARDIOLOGICA, (1994) 49/2 (145-155)., XP000904756 *
DUPONT A G ET AL: "The safety of adding carvedilol to hypertensive patients inadequately treated with diuretics.", EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, (1990) 38 SUPPL 2 S153-7., XP000904769 *
RUDORF J.E. ET AL: "Pharmacokinetic and pharmacodynamic interactions of combined acute administration of carvedilol and hydrochlorothiazide in hypertensive volunteers.", DRUGS, (1988) 36/SUPPL. 6 (113-117)., XP000904788 *
THOENNES C J ET AL: "EVALUATION OF A RAPIDLY DISINTEGRATING MOISTURE RESISTANT LACQUER FILM COATING", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 15, no. 2, 1989, pages 165 - 186, XP000938464, ISSN: 0363-9045 *
WIDMANN L ET AL: "Safety and antihypertensive efficacy of carvedilol and atenolol alone and in combination with hydrochlorothiazide.", EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, (1990) 38 SUPPL 2 S143-6., XP000904786 *

Also Published As

Publication number Publication date
DE69907252D1 (en) 2003-05-28
DE69907252T2 (en) 2004-01-29
TR200101470T2 (en) 2001-11-21
ES2195638T3 (en) 2003-12-01
KR100421347B1 (en) 2004-03-06
ZA200104280B (en) 2002-08-26
PT1131072E (en) 2003-08-29
JP2007077160A (en) 2007-03-29
TWI228414B (en) 2005-03-01
BR9915610A (en) 2001-08-14
CO5011053A1 (en) 2001-02-28
UY25821A1 (en) 2001-07-31
AR020287A1 (en) 2002-05-02
DK1131072T3 (en) 2003-08-11
AU765977B2 (en) 2003-10-09
US20040087578A1 (en) 2004-05-06
CN1328460A (en) 2001-12-26
US6403579B1 (en) 2002-06-11
WO2000032174A2 (en) 2000-06-08
PE20001302A1 (en) 2000-11-30
CA2352361C (en) 2007-01-02
TR200200981T2 (en) 2002-06-21
TR200200982T2 (en) 2002-06-21
CA2352361A1 (en) 2000-06-08
CN1184971C (en) 2005-01-19
US20020052367A1 (en) 2002-05-02
EP1131072B1 (en) 2003-04-23
JP2002531395A (en) 2002-09-24
AU1506500A (en) 2000-06-19
MY121831A (en) 2006-02-28
ATE238056T1 (en) 2003-05-15
KR20010080578A (en) 2001-08-22
EP1131072A2 (en) 2001-09-12

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