WO2000013018A3 - Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers - Google Patents

Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers Download PDF

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Publication number
WO2000013018A3
WO2000013018A3 PCT/EP1999/006317 EP9906317W WO0013018A3 WO 2000013018 A3 WO2000013018 A3 WO 2000013018A3 EP 9906317 W EP9906317 W EP 9906317W WO 0013018 A3 WO0013018 A3 WO 0013018A3
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WIPO (PCT)
Prior art keywords
support
producing
channels
determining analytes
multitude
Prior art date
Application number
PCT/EP1999/006317
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English (en)
French (fr)
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WO2000013018A2 (de
WO2000013018B1 (de
Inventor
Cord F Staehler
Peer F Staehler
Manfred Mueller
Fritz Staehler
Hans Lindner
Original Assignee
Febit Ferrarius Biotech Gmbh
Cord F Staehler
Peer F Staehler
Manfred Mueller
Fritz Staehler
Hans Lindner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27512654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000013018(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU57424/99A priority Critical patent/AU749884B2/en
Priority to EP99944538A priority patent/EP1117478B1/de
Priority to CA002341896A priority patent/CA2341896A1/en
Priority to DE59912120T priority patent/DE59912120D1/de
Priority to JP2000571081A priority patent/JP2002525590A/ja
Application filed by Febit Ferrarius Biotech Gmbh, Cord F Staehler, Peer F Staehler, Manfred Mueller, Fritz Staehler, Hans Lindner filed Critical Febit Ferrarius Biotech Gmbh
Priority to AT99944538T priority patent/ATE296677T1/de
Priority to US09/763,914 priority patent/US7097974B1/en
Publication of WO2000013018A2 publication Critical patent/WO2000013018A2/de
Publication of WO2000013018A3 publication Critical patent/WO2000013018A3/de
Publication of WO2000013018B1 publication Critical patent/WO2000013018B1/de
Priority to US11/510,565 priority patent/US20070031877A1/en

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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
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Abstract

Es wird ein Träger (40) für Analytbestimmungsverfahren angegeben, umfassend eine Vielzahl von Kanälen (1), insbesondere Kapillarkanälen, wobei in den Kanälen (1) eine Vielzahl von unterschiedlichen Rezeptoren insbesondere durch Belichtung immobilisiert ist. Ferner wird ein Verfahren zur Herstellung eines solches Trägers beschrieben. Der Träger (40) umfasst vorzugsweise auch Reservoirs (T, G, A, C) für die einzelnen Einsatzstoffe, ein Gaseinlass (3), ein Ventil (5), eine Probeneingabe (7) und ein Zugang (9) für weitere Synthesechemikalien.
PCT/EP1999/006317 1998-08-28 1999-08-27 Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers WO2000013018A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US09/763,914 US7097974B1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support
EP99944538A EP1117478B1 (de) 1998-08-28 1999-08-27 Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
CA002341896A CA2341896A1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support
DE59912120T DE59912120D1 (de) 1998-08-28 1999-08-27 Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
JP2000571081A JP2002525590A (ja) 1998-08-28 1999-08-27 分析物測定法のための支持体および該支持体を製造する方法
AU57424/99A AU749884B2 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support
AT99944538T ATE296677T1 (de) 1998-08-28 1999-08-27 Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
US11/510,565 US20070031877A1 (en) 1998-08-28 2006-08-28 Support for analyte determination methods and method for producing the support

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE19839254.0 1998-08-28
DE19839256.7 1998-08-28
DE19839255.9 1998-08-28
DE19839254 1998-08-28
DE19839255 1998-08-28
DE19839256 1998-08-28
DE19907080.6 1999-02-19
DE19907080 1999-02-19
DE19924327 1999-05-27
DE19924327.1 1999-05-27

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/763,914 A-371-Of-International US7097974B1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support
US10/727,566 Division US20040175734A1 (en) 1998-08-28 2003-12-05 Support for analyte determination methods and method for producing the support
US11/510,565 Continuation US20070031877A1 (en) 1998-08-28 2006-08-28 Support for analyte determination methods and method for producing the support

Publications (3)

Publication Number Publication Date
WO2000013018A2 WO2000013018A2 (de) 2000-03-09
WO2000013018A3 true WO2000013018A3 (de) 2000-09-14
WO2000013018B1 WO2000013018B1 (de) 2000-10-26

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Application Number Title Priority Date Filing Date
PCT/EP1999/006315 WO2000012123A2 (de) 1998-08-28 1999-08-27 Verfahren und messeinrichtung zur bestimmung einer vielzahl von analyten in einer probe
PCT/EP1999/006317 WO2000013018A2 (de) 1998-08-28 1999-08-27 Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
PCT/EP1999/006316 WO2000013017A2 (de) 1998-08-28 1999-08-27 Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern

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PCT/EP1999/006315 WO2000012123A2 (de) 1998-08-28 1999-08-27 Verfahren und messeinrichtung zur bestimmung einer vielzahl von analyten in einer probe

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/006316 WO2000013017A2 (de) 1998-08-28 1999-08-27 Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern

Country Status (8)

Country Link
US (5) US7097974B1 (de)
EP (6) EP2273270A1 (de)
JP (3) JP2002525590A (de)
AT (4) ATE357289T1 (de)
AU (3) AU771238B2 (de)
CA (2) CA2341894A1 (de)
DE (8) DE59914270D1 (de)
WO (3) WO2000012123A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7737088B1 (en) 1998-08-28 2010-06-15 Febit Holding Gmbh Method and device for producing biochemical reaction supporting materials

Families Citing this family (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6426184B1 (en) 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US7101914B2 (en) 1998-05-04 2006-09-05 Natural Asa Isomer enriched conjugated linoleic acid compositions
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
NZ511560A (en) * 1998-11-05 2002-11-26 Chemometec As A method for the assessment of particles and a system and a device for use in the method
EP1728860B1 (de) 1999-02-19 2010-01-27 febit holding GmbH Verfahren zur Herstellung von Polymeren
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
ATE264718T1 (de) * 1999-07-02 2004-05-15 Clondiag Chip Tech Gmbh Microchip-matrix-vorrichtung zur vervielfältigung und charakterisierung von nukleinsäuren
JP2001078175A (ja) * 1999-07-07 2001-03-23 Fuji Photo Film Co Ltd 蛍光観察装置
JP2001070227A (ja) 1999-07-07 2001-03-21 Fuji Photo Film Co Ltd 蛍光観察装置
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US20050164293A1 (en) * 1999-11-29 2005-07-28 Peer Stahler Dynamic determination of analytes
DE19962803A1 (de) * 1999-12-23 2001-07-05 Basf Ag Verfahren und Vorrichtung zur maskenfreien Herstellung von Biopolymeren
DE10024132B4 (de) * 2000-01-28 2007-03-22 Leica Microsystems Cms Gmbh Anordnung zur Detektion von Fluoreszenzlicht mehrerer Probenpunkte
DE10013254A1 (de) * 2000-03-17 2001-10-04 Friz Biochem Gmbh Vorrichtung und Verfahren zum Nachweis organischer Moleküle in einer Probensubstanz
CA2404799C (en) 2000-04-06 2007-08-07 Conlinco, Inc. Conjugated linoleic acid compositions
EP1274320A2 (de) 2000-04-18 2003-01-15 Natural AS Konjugiertes linoleinsäurepulver
DE10023423B4 (de) * 2000-05-12 2009-03-05 Gnothis Holding Sa Direkter Nachweis von Einzelmolekülen
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7892854B2 (en) * 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001271893A1 (en) * 2000-07-07 2002-01-21 Nimblegen Systems, Inc. Method and apparatus for synthesis of arrays of dna probes
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
US6576472B1 (en) * 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
FR2813121A1 (fr) * 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
ATE303863T1 (de) * 2000-10-17 2005-09-15 Febit Ag Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger
DE10051396A1 (de) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
DE10058095C2 (de) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Vorrichtung zur Bestimmung von Analyten durch Chemilumineszenz
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
DE10060433B4 (de) * 2000-12-05 2006-05-11 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zur Herstellung eines Fluidbauelements, Fluidbauelement und Analysevorrichtung
DE10062244A1 (de) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor zur Detektion von makromolekularen Biopolymeren, Sensoranordnung, Verfahren zur Detektion von makromolekularen Biopolymeren und Verfahren zum Herstellen eines Sensors zur Detektion von makromolekularen Biopolymeren
DE10103954B4 (de) 2001-01-30 2005-10-06 Advalytix Ag Verfahren zur Analyse von Makromolekülen
DE10113711A1 (de) * 2001-03-16 2002-09-26 Lifebits Ag Verfahren zum Nachweis biochemischer Reaktionen und Messträger zur Durchführung des Verfahrens
DE10115474A1 (de) * 2001-03-29 2002-10-10 Infineon Technologies Ag Mikrofluidkanalstruktur und Verfahren zur Herstellung einer derartigen Mikrofluidkanalstruktur
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
US20020160427A1 (en) * 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes
DE10122357A1 (de) * 2001-05-09 2002-11-14 Febit Ferrarius Biotech Gmbh Hybridverfahren zur Herstellung von Trägern für die Analytbestimmung
CA2452693A1 (en) 2001-06-06 2002-12-12 Digital Optical Imaging Corporation Light modulated microarray reader and methods relating thereto
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
DE10136008B4 (de) * 2001-07-24 2005-03-31 Advalytix Ag Verfahren zur Analyse von Makromolekülen und Verfahren zur Herstellung einer Analysevorrichtung
DE10142691B4 (de) * 2001-08-31 2006-04-20 Infineon Technologies Ag Verfahren zum Nachweis biochemischer Reaktionen sowie eine Vorrichtung hierfür
EP1432786B1 (de) 2001-09-06 2009-07-22 Genomic Profiling Systems, Inc. Schnellnachweis replizierender zellen
DE10145700A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip-Anordnung, Sensor-Anordnung und Verfahren zum Betreiben einer Biochip-Anordnung
DE10145701A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Fluoreszenz-Biosensorchip und Fluoreszenz-Biosensorchip-Anordnung
DE10148102B4 (de) * 2001-09-28 2006-03-30 Biotez Berlin-Buch Gmbh Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen, seine Verwendung und Verfahren zum quantitativen Nachweis von Biomolekülen durch fotometrisches Erfassen einer Farbreaktion
DE10149947A1 (de) 2001-10-10 2003-04-17 Febit Ferrarius Biotech Gmbh Mikrofluidisches Extraktionsverfahren
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
DE10152925A1 (de) * 2001-10-26 2003-05-08 Febit Ag Asymmetrische Sonden
US7413859B2 (en) 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
DE10155892A1 (de) * 2001-11-14 2003-05-28 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren und Biosensor zum Erfassen von makromolekularen Biopolymeren
DE10156467A1 (de) * 2001-11-16 2003-06-05 Micronas Gmbh Träger zur Synthese sowie Verfahren zur Herstellung von Biopolymeren
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10160987B4 (de) * 2001-12-05 2005-08-04 Siemens Ag Baueinheit zur simultanen, optischen Beleuchtung einer Vielzahl von Proben
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
DE10206548B4 (de) * 2002-02-13 2005-06-16 Siemens Ag Verfahren zur Analyse von Probenbestandteile tragenden Trägerplatten und Vorrichtungen zur Durchführung dieses Verfahrens
DE10208770A1 (de) * 2002-02-28 2003-09-04 Febit Ag Erhöhung der Sensitivität und Spezifität von Hybridisierungsexperimenten mit Nukleinsäure-Chips
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
DE10215319A1 (de) * 2002-04-02 2003-10-30 Siemens Ag Gerät zur Beleuchtung einer zu untersuchenden Probenplatte
EP2775291B1 (de) 2002-05-17 2016-01-13 Life Technologies Corporation Vorrichtung zur Unterscheidung mehrerer Fluoreszenzsignale anhand ihrer Anregungswellenlänge
DE10224825A1 (de) * 2002-06-05 2003-12-24 Eppendorf Ag Verfahren zur Analyse von Biomolekülen
FR2842826B1 (fr) * 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
JP2004069559A (ja) 2002-08-07 2004-03-04 Seiko Epson Corp 製造システム、その制御装置、制御方法、制御システム及び制御プログラム
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
DE10242530A1 (de) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Lichtquelle für ein Meßsystem mit photoempfindlicher Elektrode zum Nachweis eines oder mehrerer Analyten
DE10242529A1 (de) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Meßsystem mit photoempfindlicher Elektrode
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US6743931B2 (en) 2002-09-24 2004-06-01 Natural Asa Conjugated linoleic acid compositions
DE10245432A1 (de) * 2002-09-27 2004-04-08 Micronas Gmbh Verfahren und Vorrichtung zum Detektieren mindestens eines Lumineszenz-Stoffs
DE10245845B4 (de) * 2002-09-30 2006-06-29 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Meßchip für die Verwendung ein einer Vorrichtung zur quantitativen Bestimmung eines Analyten in einer Probe und Vorrichtung mit diesem Meßchip
US7305112B2 (en) * 2002-10-15 2007-12-04 The Scripps Research Institute Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7220592B2 (en) * 2002-11-15 2007-05-22 Eksigent Technologies, Llc Particulate processing system
US7175810B2 (en) 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
DE50310049D1 (de) * 2002-12-23 2008-08-07 Febit Biotech Gmbh Einbau von hapten-gruppen bei der herstellung von trägern für die analytbestimmung
EP1596978A2 (de) * 2002-12-23 2005-11-23 febit biotech GmbH Verfahren zum validierten aufbau von arrays
DE10312670A1 (de) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Substrat zur kontrollierten Benetzung vorbestimmter Benetzungsstellen mit kleinen Flüssigkeitsvolumina, Substratabdeckung und Flusskammer
EP1625386B8 (de) * 2003-03-24 2021-07-28 Intuity Medical, Inc. Vorrichtungen und verfahren zum nachweis von analytkonzentrationen
US7300755B1 (en) * 2003-05-12 2007-11-27 Fred Hutchinson Cancer Research Center Methods for haplotyping genomic DNA
JP2004361158A (ja) * 2003-06-03 2004-12-24 Moritex Corp 生化学検出装置及び検出方法
US8133670B2 (en) 2003-06-13 2012-03-13 Cold Spring Harbor Laboratory Method for making populations of defined nucleic acid molecules
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050209787A1 (en) * 2003-12-12 2005-09-22 Waggener Thomas B Sequencing data analysis
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
DE102004015272A1 (de) * 2004-03-29 2005-11-03 Infineon Technologies Ag Biosensor-Anordnung zum Erfassen von Biomolekülen und Verfahren zum Erfassen von Biomolekülen
DE102004021904B4 (de) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Verfahren und Vorrichtung zur Erzeugung einer Analyseanordnung mit diskreten, separaten Messbereichen zur biologischen, biochemischen oder chemischen Analyse
US7751048B2 (en) * 2004-06-04 2010-07-06 California Institute Of Technology Optofluidic microscope device
US7773227B2 (en) * 2004-06-04 2010-08-10 California Institute Of Technology Optofluidic microscope device featuring a body comprising a fluid channel and having light transmissive regions
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7291824B2 (en) * 2005-12-22 2007-11-06 Palo Alto Research Center Incorporated Photosensing throughout energy range and in subranges
US7522786B2 (en) * 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
WO2006029234A1 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
DE102004056787A1 (de) * 2004-11-24 2006-06-01 Heinrich-Heine-Universität Düsseldorf Vorrichtung und Verfahren zur Messung von Fluoreszenz in mehreren Reaktionsräumen
TWI295730B (en) * 2004-11-25 2008-04-11 Ind Tech Res Inst Microfluidic chip for sample assay and method thereof
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
AU2006236410B2 (en) * 2005-04-19 2012-11-01 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
DE102005018337A1 (de) * 2005-04-20 2006-11-02 Micronas Gmbh Mikrooptisches Detektionssystem und Verfahren zur Bestimmung temperaturabhängiger Parameter von Analyten
GB0509833D0 (en) * 2005-05-16 2005-06-22 Isis Innovation Cell analysis
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
JP4607684B2 (ja) * 2005-06-29 2011-01-05 富士フイルム株式会社 流路ブロック、センサユニット、及び全反射減衰を利用した測定装置
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7760274B2 (en) 2005-12-08 2010-07-20 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array, apparatus for fabricating biomolecule array or polymer array including the programmable mask, and method of fabricating biomolecule array or polymer array using the programmable mask
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US7547904B2 (en) * 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7768654B2 (en) 2006-05-02 2010-08-03 California Institute Of Technology On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference
US9041938B2 (en) 2006-05-02 2015-05-26 California Institute Of Technology Surface wave assisted structures and systems
JP4431549B2 (ja) * 2006-05-31 2010-03-17 株式会社日立ハイテクノロジーズ 蛍光分析装置
US20120269728A1 (en) * 2006-08-02 2012-10-25 Antara Biosciences Inc. Methods and compositions for detecting one or more target agents using tracking components
DE102006039479A1 (de) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmierbare Oligonukleotidsynthese
WO2008049795A1 (en) * 2006-10-23 2008-05-02 Flexgen Bv Method and system for calibrating laser focus and position in micro-arrays
US7532128B2 (en) * 2006-10-25 2009-05-12 Alverix, Inc. Position sensitive indicator detection
DE102006056949B4 (de) * 2006-11-30 2011-12-22 Ruprecht-Karls-Universität Heidelberg Verfahren und Vorrichtung zur Detektion mindestens einer Eigenschaft von mindestens einem Objekt mit einem Mikrochip
DE102007018833A1 (de) 2007-04-20 2008-10-23 Febit Holding Gmbh Verbesserte molekularbiologische Prozessanlage
DE102006062089A1 (de) 2006-12-29 2008-07-03 Febit Holding Gmbh Verbesserte molekularbiologische Prozessanlage
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US7852490B2 (en) * 2007-02-05 2010-12-14 Palo Alto Research Center Incorporated Implanting optical cavity structures
US7936463B2 (en) * 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
US7633629B2 (en) * 2007-02-05 2009-12-15 Palo Alto Research Center Incorporated Tuning optical cavities
US7529438B2 (en) * 2007-07-13 2009-05-05 Palo Alto Research Center Incorporated Producing fluidic waveguides
US7522811B2 (en) * 2007-07-13 2009-04-21 Palo Alto Research Center Incorporated Producing sandwich waveguides
ES2488090T3 (es) * 2007-07-27 2014-08-26 F. Hoffmann-La Roche Ag Etiqueta de identificación de la orientación, estructura portadora de contenedores de reactivos y dispositivo analizador
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
DE102007054602A1 (de) * 2007-11-15 2009-05-28 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Messaufbau zum Erfassen der Verteilung mindestens einer Zustandsgröße in einem Messfeld mit verschiedenen Sonden
DE202007019582U1 (de) 2007-11-15 2014-01-30 Deutsches Zentrum für Luft- und Raumfahrt e.V. Messaufbau zum Erfassen der Verteilung mindestens einer Zustandsgröße in einem Messfeld mit verschiedenen Sonden
DE102007056398A1 (de) 2007-11-23 2009-05-28 Febit Holding Gmbh Flexibles Extraktionsverfahren für die Herstellung sequenzspezifischer Molekülbibliotheken
US8320983B2 (en) * 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US8373860B2 (en) 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
WO2009111573A2 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Optofluidic microscope device with photosensor array
WO2009111577A1 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Methods of using optofluidic microscope devices
US8325349B2 (en) * 2008-03-04 2012-12-04 California Institute Of Technology Focal plane adjustment by back propagation in optofluidic microscope devices
DE102008021365A1 (de) * 2008-04-29 2009-01-22 Siemens Aktiengesellschaft Verfahren zum Einbringen von Reagenzien in Mikrokanäle einer Analyseeinheit
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
CN107329280A (zh) 2008-09-25 2017-11-07 纽约市哥伦比亚大学托管会 提供光刺激和结构成像的装置、设备和方法
RU2385940C1 (ru) * 2008-10-23 2010-04-10 Общество с ограниченной ответственностью "ВИНТЕЛ" Способ определения нуклеиновых кислот методом полимеразно-цепной реакции в режиме реального времени и устройство для его осуществления
EP2380055A4 (de) * 2009-01-21 2012-07-11 California Inst Of Techn Quantitative differentialinterferenzkontrastvorrichtung für computergestützte tiefensektionierung
WO2010094772A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
WO2010106109A1 (en) 2009-03-17 2010-09-23 Febit Holding Gmbh Multi-use of biochips
DE102009014080B4 (de) * 2009-03-23 2011-12-15 Baumer Innotec Ag Vorrichtung zum Bestimmen von Partikelgrössen
FR2943789B1 (fr) * 2009-03-26 2013-07-26 Commissariat Energie Atomique Procede et dispositif pour la caracterisation de la dynamique de coagulation ou sedimentation d'un fluide tel que le sang ou le plasma sanguin
KR20100109196A (ko) * 2009-03-31 2010-10-08 삼성전자주식회사 빛의 투과량 또는 반사량을 이용한 검출 대상물의 농도 측정시스템 및 방법
US8300971B2 (en) * 2009-04-17 2012-10-30 LevelSet Systems, Inc. Method and apparatus for image processing for massive parallel DNA sequencing
US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
WO2011035299A2 (en) * 2009-09-21 2011-03-24 California Institute Of Technology Reflective focusing and transmissive projection device
CN101698146B (zh) * 2009-09-24 2011-10-26 复旦大学附属肿瘤医院 用于合成放射性药物的微量反应器及其应用
JP5012873B2 (ja) * 2009-10-14 2012-08-29 カシオ計算機株式会社 画像処理装置
CN105974571B (zh) 2009-10-28 2019-05-28 阿兰蒂克微科学股份有限公司 显微成像
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
WO2011054614A1 (en) * 2009-11-05 2011-05-12 Waterford Institute Of Technology A nanohole array biosensor
EP2542890B1 (de) 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CN102792151B (zh) * 2010-03-23 2015-11-25 加州理工学院 用于2d和3d成像的超分辨率光流体显微镜
DE102010018678B4 (de) 2010-04-28 2017-06-29 Sartorius Stedim Biotech Gmbh Bioreaktoranordnung, Schüttelvorrichtung und Verfahren zum Bestrahlen eines Mediums in einem Bioreaktor
SE535918C2 (sv) * 2010-06-10 2013-02-19 Hemocue Ab Detektion av magnetiskt inmärkta biologiska komponenter
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
WO2012030995A2 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Optical system for high resolution thermal melt detection
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9643184B2 (en) 2010-10-26 2017-05-09 California Institute Of Technology e-Petri dishes, devices, and systems having a light detector for sampling a sequence of sub-pixel shifted projection images
US9426429B2 (en) 2010-10-26 2016-08-23 California Institute Of Technology Scanning projective lensless microscope system
US9569664B2 (en) 2010-10-26 2017-02-14 California Institute Of Technology Methods for rapid distinction between debris and growing cells
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
CN103534627A (zh) 2011-03-03 2014-01-22 加州理工学院 光导像素
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US9117149B2 (en) 2011-10-07 2015-08-25 Industrial Technology Research Institute Optical registration carrier
PL3327110T3 (pl) 2011-11-07 2020-07-27 Rapid Micro Biosystems, Inc. Kaseta do badania sterylności
KR20130073354A (ko) * 2011-12-23 2013-07-03 한국전자통신연구원 바이오 칩 분석 장치
CN107841461A (zh) 2012-04-16 2018-03-27 快速微型生物系统公司 细胞培养装置
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
DE102013106432A1 (de) * 2013-06-20 2014-12-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Optische Indikator-Einheit und Vorrichtung und Verfahren zur Bestimmung einer physikalisch-chemischen Eigenschaft eines Prozessmediums in einer prozesstechnischen Anlage
CN110058005A (zh) 2013-06-26 2019-07-26 阿兰蒂克微科学股份有限公司 用于显微的样品处理改进
ES2943498T3 (es) 2013-08-05 2023-06-13 Twist Bioscience Corp Genotecas sintetizadas de novo
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
DE102015003019A1 (de) * 2015-03-06 2016-09-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur optischen Detektion einer Bewegung in einer biologischen Probe mit räumlicher Ausdehnung
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3104208B1 (de) * 2015-06-09 2022-08-24 Nokia Technologies Oy Elektrisches schaltkreis zur ventilsteuerung zur übertragungssteuerung einer optisch aktiven flüssigkeit von einem ersten reservoir zu einem zweiten reservoir
WO2017010375A1 (ja) * 2015-07-10 2017-01-19 ヤマト科学株式会社 組織試料分析装置及び組織試料分析システム
JP6239562B2 (ja) * 2015-09-14 2017-11-29 株式会社東芝 照明デバイスおよびそれを備えるバイオ情報計測装置
GB2557529A (en) 2015-09-18 2018-06-20 Twist Bioscience Corp Oligonucleic acid variant libraries and synthesis thereof
WO2017053450A1 (en) 2015-09-22 2017-03-30 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
WO2017095958A1 (en) 2015-12-01 2017-06-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
CN106248764B (zh) * 2016-08-03 2020-03-24 南京山诺生物科技有限公司 一种实时可视共享及一体成像的核酸电泳装置及其操作方法
CN109996876A (zh) 2016-08-22 2019-07-09 特韦斯特生物科学公司 从头合成的核酸文库
WO2018057526A2 (en) 2016-09-21 2018-03-29 Twist Bioscience Corporation Nucleic acid based data storage
KR20180046098A (ko) * 2016-10-27 2018-05-08 삼성전자주식회사 검사장치, 검사 시스템 및 검사장치의 제어방법
AU2017378492B2 (en) 2016-12-16 2022-06-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US11550939B2 (en) 2017-02-22 2023-01-10 Twist Bioscience Corporation Nucleic acid based data storage using enzymatic bioencryption
CA3056388A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018231872A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
SG11202002194UA (en) 2017-09-11 2020-04-29 Twist Bioscience Corp Gpcr binding proteins and synthesis thereof
KR20240024357A (ko) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
DE102017127671A1 (de) * 2017-11-23 2019-05-23 Osram Opto Semiconductors Gmbh Photonischer Gassensor und Verfahren zur Herstellung eines photonischen Gassensors
KR20200106067A (ko) 2018-01-04 2020-09-10 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
EP3814497A4 (de) 2018-05-18 2022-03-02 Twist Bioscience Corporation Polynukleotide, reagenzien und verfahren zur nukleinsäurehybridisierung
US11684903B2 (en) 2018-10-24 2023-06-27 Daniel Shafer Microscale chemical reactors
CN109289725A (zh) * 2018-11-14 2019-02-01 山东金德新材料有限公司 一种新型微通道反应器
WO2020127828A1 (de) * 2018-12-21 2020-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung, vermessungssystem und verfahren zur erfassung einer zumindest teilweise spiegelnden oberfläche unter verwendung zweier spiegelungsmuster
CN113785057A (zh) 2019-02-26 2021-12-10 特韦斯特生物科学公司 用于抗体优化的变异核酸文库
CA3131689A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
AU2020298294A1 (en) 2019-06-21 2022-02-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
DE102020123949A1 (de) 2020-09-15 2022-03-17 IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH (IMMS GmbH) Elektrochemische Sensoranordnung und Verwendung eines fotoelektrischen Sensors zur Bestimmung von Ladungsträgern in einem Medium
WO2023187429A1 (en) * 2022-03-31 2023-10-05 Thalesnano Zrt Flow-through type apparatus for performing chemical reaction of reagents principally in space

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001559A2 (de) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Probenträger und seine verwendung
WO1996010747A1 (en) * 1994-09-30 1996-04-11 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
WO1997019749A1 (en) * 1995-11-27 1997-06-05 Dehlinger Peter J Method and apparatus for producing position-addressable combinatorial libraries
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection
US5755942A (en) * 1994-11-10 1998-05-26 David Sarnoff Research Center, Inc. Partitioned microelectronic device array

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1107714A (en) * 1964-04-18 1968-03-27 Dowty Technical Dev Ltd Hydraulic power transmission
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3301833A1 (de) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
DE8309254U1 (de) 1983-03-29 1985-01-03 Straub, Hans, Dipl.-Ing.(FH), 7345 Deggingen Verteilereinheit fuer die rohre von zentralheizungsanlagen
DE3322373C2 (de) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
SE8303626D0 (sv) 1983-06-23 1983-06-23 Kabigen Ab A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced
ATE143289T1 (de) * 1984-06-13 1996-10-15 Applied Research Systems Vorrichtung, mit verwendung in chemischen prüfverfahren
EP0316018A3 (de) 1985-03-29 1989-07-26 Cetus Oncology Corporation Modifikation von DNS-Sequenzen
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
GB8714270D0 (en) * 1987-06-18 1987-07-22 Williams G R Analysis of carbohydrates
US5162863A (en) * 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
JPH03505966A (ja) 1988-07-14 1991-12-26 ベイラー カレッジ オブ メディシン 生物高分子の固相組立及び再構築方法
ATE143696T1 (de) 1989-02-28 1996-10-15 Canon Kk Partiell doppelsträngiges oligonukleotid und verfahren zu seiner bildung
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
FR2652423B1 (fr) 1989-09-22 1992-05-22 Ardt Rgle Dev Techn Procede de microlithographie pour la realisation de structures superficielles submicrometriques sur un substrat du type d'une plaquette de silicium, ainsi qu'un dispositif le mettant en óoeuvre.
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
WO1991018276A1 (en) 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
EP0562025B1 (de) 1990-12-06 2001-02-07 Affymetrix, Inc. (a Delaware Corporation) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
EP0493137B1 (de) 1990-12-28 1998-09-23 Research Development Corporation of Japan Verfahren zur Bildung ultrafeiner Strukturen
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5239176A (en) * 1991-10-03 1993-08-24 Foster-Miller, Inc. Tapered optical fiber sensing attenuated total reflectance
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5247180A (en) 1991-12-30 1993-09-21 Texas Instruments Incorporated Stereolithographic apparatus and method of use
US5258295A (en) * 1992-02-25 1993-11-02 Glyko, Inc. Fluorophore-assisted cloning analysis
GB9206671D0 (en) 1992-03-27 1992-05-13 Cranfield Biotech Ltd Electrochemical detection of dna hybridisation
DK0660936T3 (da) * 1992-09-14 1999-05-25 Stanford Res Inst Int Op-konverterende reportermolekyle til biologiske og andre assays under anvendelse af laserexcitationsteknik
WO1994012632A1 (en) 1992-11-27 1994-06-09 University College London Improvements in nucleic acid synthesis by pcr
DE4241871A1 (de) 1992-12-11 1994-06-16 Schulz Rudolf Ing Grad Molekularer Computer durch atomare Chips in Verbindung mit optischem Transistor sowie assoziativen Speichern
US5368823A (en) 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
DE4325724A1 (de) 1993-07-30 1995-02-02 Paul Dr Debbage Vorrichtung und Verfahren zur Untersuchung eines Objektes und zur Einwirkung auf das Objekt
AU671688B2 (en) 1993-09-28 1996-09-05 Beckman Instruments, Inc. Biopolymer synthesis utilizing surface activated, organic polymers
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
DE69422604T2 (de) 1994-03-08 2000-06-08 Zeptosens Ag Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
US5891738A (en) * 1995-01-16 1999-04-06 Erkki Soini Biospecific multiparameter assay method
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6066448A (en) 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
US5736257A (en) * 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5582705A (en) * 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
WO1997006468A2 (en) 1995-07-28 1997-02-20 Ely Michael Rabani Pattern formation, replication, fabrication and devices thereby
US5807525A (en) 1995-08-17 1998-09-15 Hybridon, Inc. Apparatus and process for multi stage solid phase synthesis of long chained organic molecules
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5728251A (en) 1995-09-27 1998-03-17 Research Frontiers Inc Light modulating film of improved UV stability for a light valve
US5667195A (en) * 1995-11-13 1997-09-16 Matthew Howard McCormick Fluid drain apparatus
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
JP3233851B2 (ja) 1996-04-24 2001-12-04 繁織 竹中 遺伝子の電気化学的検出法およびその装置
JP2000510233A (ja) 1996-04-25 2000-08-08 ペンス，インコーポレイテッド バイオセンサ装置および方法
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
WO1998003683A1 (en) 1996-07-19 1998-01-29 The Regents Of The University Of Michigan Dna encoding canine von willebrand factor and methods of use
US5871628A (en) 1996-08-22 1999-02-16 The University Of Texas System Automatic sequencer/genotyper having extended spectral response
GB9621122D0 (en) * 1996-10-10 1996-11-27 Cambridge Imaging Ltd Improvements in and relating to methods and apparatus for assay analysis
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
IES80556B2 (en) 1997-01-10 1998-09-23 Robert Arpad Foster Electrochemical diagnostic detection device
US5812272A (en) 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
CA2291180A1 (en) * 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
DE69838067T2 (de) 1997-05-23 2008-03-13 Bioarray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
DE19726634A1 (de) 1997-06-18 1998-12-24 Biotools Inst Fuer Computerint Verfahren und Vorrichtung zur Immobilisierung von Makromolekülen
AU745989B2 (en) 1997-08-13 2002-04-11 Cepheid Microstructures for the manipulation of fluid samples
JP3938982B2 (ja) * 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
AU9393398A (en) 1997-09-16 1999-04-05 Egea Biosciences, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
EP1021558A1 (de) 1997-10-10 2000-07-26 President And Fellows Of Harvard College Oberflächengebundene, doppelsträngige dna-protein-arrays
US6177558B1 (en) 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US20020076735A1 (en) * 1998-09-25 2002-06-20 Williams Lewis T. Diagnostic and therapeutic methods using molecules differentially expressed in cancer cells
JP2002500897A (ja) 1998-01-27 2002-01-15 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
AU2586799A (en) 1998-02-06 1999-08-23 Affymetrix, Inc. Method of quality control in manufacturing processes
US6426184B1 (en) * 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
JP4698023B2 (ja) 1998-02-23 2011-06-08 ウイスコンシン アラムニ リサーチ ファンデーション Ｄｎａプローブのアレイの合成方法及び合成装置
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
DE19823454A1 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren zur photolithographischen Herstellung von DNA, PNA und Protein Chips
WO1999060170A1 (en) 1998-05-21 1999-11-25 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
DE19823876B4 (de) 1998-05-28 2004-07-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mit unterschiedlichen Verbindungen beladenes Bauteil (Biochip) sowie Verfahren zu dessen Herstellung
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
WO1999063385A1 (en) * 1998-06-04 1999-12-09 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US7097974B1 (en) 1998-08-28 2006-08-29 Febit Biotech Gmbh Support for a method for determining an analyte and a method for producing the support
DE19842164B4 (de) 1998-09-15 2004-06-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur Qualitätskontrolle beim Aufbau von Oligomerrastern
DE19921940C2 (de) 1998-11-23 2003-02-06 Friz Biochem Gmbh Verfahren zur elektrochemischen Detektion von Nukleinsäureoligomerhybriden
DE19964220C2 (de) 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
DE19901761A1 (de) 1999-01-18 1999-07-01 Gerhard Dr Hartwich Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
WO2000042217A2 (de) 1999-01-18 2000-07-20 Fritz, Biochem Gmbh Verfahren zur elektrochemischen detektion von nukleinsäure -oligomer- hybridisierungsereignissen
EP1728860B1 (de) 1999-02-19 2010-01-27 febit holding GmbH Verfahren zur Herstellung von Polymeren
DE19910392B4 (de) 1999-03-05 2005-03-17 Clondiag Chip Technologies Gmbh Mikrosäulenreaktor
WO2000053617A1 (en) 1999-03-08 2000-09-14 Protogene Laboratories, Inc. Methods and compositions for economically synthesizing and assembling long dna sequences
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
ATE303863T1 (de) 2000-10-17 2005-09-15 Febit Ag Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger
US20020160427A1 (en) 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
WO1995001559A2 (de) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Probenträger und seine verwendung
WO1996010747A1 (en) * 1994-09-30 1996-04-11 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5755942A (en) * 1994-11-10 1998-05-26 David Sarnoff Research Center, Inc. Partitioned microelectronic device array
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
WO1997019749A1 (en) * 1995-11-27 1997-06-05 Dehlinger Peter J Method and apparatus for producing position-addressable combinatorial libraries
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. D. HOHEISEL: "Oligomer-chip technology", TRENDS IN BIOTECHNOLOGY., vol. 15, no. 11, November 1997 (1997-11-01), ELSEVIER PUBLICATIONS, CAMBRIDGE., GB, pages 465-469 - 469, XP004092669, ISSN: 0167-7799 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7737088B1 (en) 1998-08-28 2010-06-15 Febit Holding Gmbh Method and device for producing biochemical reaction supporting materials

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