WO2000013017A3 - Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern - Google Patents

Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern Download PDF

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Publication number
WO2000013017A3
WO2000013017A3 PCT/EP1999/006316 EP9906316W WO0013017A3 WO 2000013017 A3 WO2000013017 A3 WO 2000013017A3 EP 9906316 W EP9906316 W EP 9906316W WO 0013017 A3 WO0013017 A3 WO 0013017A3
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WO
WIPO (PCT)
Prior art keywords
producing
illumination
matrix
supporting materials
biochemical reaction
Prior art date
Application number
PCT/EP1999/006316
Other languages
English (en)
French (fr)
Other versions
WO2000013017A9 (de
WO2000013017A2 (de
Inventor
Cord F Staehler
Peer F Staehler
Manfred Mueller
Fritz Staehler
Hans Lindner
Original Assignee
Febit Ferrarius Biotech Gmbh
Cord F Staehler
Peer F Staehler
Manfred Mueller
Fritz Staehler
Hans Lindner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27512654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000013017(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Febit Ferrarius Biotech Gmbh, Cord F Staehler, Peer F Staehler, Manfred Mueller, Fritz Staehler, Hans Lindner filed Critical Febit Ferrarius Biotech Gmbh
Priority to US09/763,607 priority Critical patent/US7737088B1/en
Priority to JP2000567951A priority patent/JP2002523781A/ja
Priority to AU59713/99A priority patent/AU771238B2/en
Priority to DE59915204T priority patent/DE59915204D1/de
Priority to EP99968261A priority patent/EP1117996B1/de
Priority to CA002341894A priority patent/CA2341894A1/en
Priority to AT99968261T priority patent/ATE481637T1/de
Priority to AT00909211T priority patent/ATE334197T1/de
Priority to DE50013228T priority patent/DE50013228D1/de
Priority to US09/869,332 priority patent/US6586211B1/en
Priority to AU31570/00A priority patent/AU767606B2/en
Priority to EP00909211A priority patent/EP1153127B1/de
Priority to DK10151688.8T priority patent/DK2175021T3/da
Priority to PCT/EP2000/001356 priority patent/WO2000049142A1/de
Priority to DE50015858T priority patent/DE50015858D1/de
Priority to EP10151688.8A priority patent/EP2175021B1/de
Priority to EP06014767A priority patent/EP1728860B1/de
Priority to AT06014767T priority patent/ATE456652T1/de
Priority to CA2362939A priority patent/CA2362939C/en
Priority to JP2000599868A priority patent/JP2002536977A/ja
Publication of WO2000013017A2 publication Critical patent/WO2000013017A2/de
Publication of WO2000013017A3 publication Critical patent/WO2000013017A3/de
Publication of WO2000013017A9 publication Critical patent/WO2000013017A9/de
Priority to US10/455,369 priority patent/US7790369B2/en
Priority to US11/785,505 priority patent/US20070196854A1/en
Priority to US11/971,805 priority patent/US20080214412A1/en
Priority to US12/400,493 priority patent/US9568839B2/en
Priority to US15/426,860 priority patent/US20170147748A1/en

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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
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Abstract

Die Erfindung befaßt sich mit der Verwendung einer zur Erzeugung eines wahlweise einstellbaren Belichtungsmusters steuerbaren Belichtungsmatrix (10, 10a, 10b) Am Bereich der Biotechnologie und insbesondere für die Herstellung und Manipulation von mit biologisch oder chemisch funktionellen Materialien beschichteten Trägern im Speziellen, wobei zur Erzeugung von Belichtungsmustern auf oder in dem Träger eine solche Belichtungsmatrix (10, 10a, 10b) herangezogen wird. Vorzugsweise wird als Belichtungsmatrix (10, 10a, 10b) eine Reflexionsmatrix (10a) mit einer gesteuert deformierbaren Spiegelanordnung verwendet.
PCT/EP1999/006316 1998-08-28 1999-08-27 Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern WO2000013017A2 (de)

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US09/763,607 US7737088B1 (en) 1998-08-28 1999-08-27 Method and device for producing biochemical reaction supporting materials
JP2000567951A JP2002523781A (ja) 1998-08-28 1999-08-27 生化学的反応支持体の製造および／または製造のための方法および装置
AU59713/99A AU771238B2 (en) 1998-08-28 1999-08-27 Method and device for producing and/or analyzing biochemical reaction supporting materials
DE59915204T DE59915204D1 (de) 1998-08-28 1999-08-27 Verfahren zur herstellung von biochemischen reaktionsträgern
EP99968261A EP1117996B1 (de) 1998-08-28 1999-08-27 Verfahren zur herstellung von biochemischen reaktionsträgern
CA002341894A CA2341894A1 (en) 1998-08-28 1999-08-27 Method and device for preparing and/or analyzing biochemical reaction carriers
AT99968261T ATE481637T1 (de) 1998-08-28 1999-08-27 Verfahren zur herstellung von biochemischen reaktionsträgern
JP2000599868A JP2002536977A (ja) 1999-02-19 2000-02-18 ポリマーの製法
DK10151688.8T DK2175021T3 (da) 1999-02-19 2000-02-18 Fremgangsmåde til fremstilling af polymerer
CA2362939A CA2362939C (en) 1999-02-19 2000-02-18 Method for producing polymers
US09/869,332 US6586211B1 (en) 1999-02-19 2000-02-18 Method for producing polymers
AU31570/00A AU767606B2 (en) 1999-02-19 2000-02-18 Method for producing polymers
EP00909211A EP1153127B1 (de) 1999-02-19 2000-02-18 Verfahren zur herstellung von polymeren
AT00909211T ATE334197T1 (de) 1999-02-19 2000-02-18 Verfahren zur herstellung von polymeren
PCT/EP2000/001356 WO2000049142A1 (de) 1999-02-19 2000-02-18 Verfahren zur herstellung von polymeren
DE50015858T DE50015858D1 (de) 1999-02-19 2000-02-18 Verfahren zur Herstellung von Polymeren
EP10151688.8A EP2175021B1 (de) 1999-02-19 2000-02-18 Verfahren zur Herstellung von Polymeren
EP06014767A EP1728860B1 (de) 1999-02-19 2000-02-18 Verfahren zur Herstellung von Polymeren
AT06014767T ATE456652T1 (de) 1999-02-19 2000-02-18 Verfahren zur herstellung von polymeren
DE50013228T DE50013228D1 (de) 1999-02-19 2000-02-18 Verfahren zur herstellung von polymeren
US10/455,369 US7790369B2 (en) 1999-02-19 2003-06-06 Method for producing polymers
US11/785,505 US20070196854A1 (en) 1999-02-19 2007-04-18 Method for producing polymers
US11/971,805 US20080214412A1 (en) 1998-08-28 2008-01-09 Method and device for preparing and/or analyzing biochemical reaction carriers
US12/400,493 US9568839B2 (en) 1999-02-19 2009-03-09 Method for producing polymers
US15/426,860 US20170147748A1 (en) 1999-02-19 2017-02-07 Method for producing polymers

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Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2290364A1 (de) 1996-04-25 2011-03-02 BioArray Solutions Ltd. Lichtgesteuerte elektrokinetische Anordnung von Partikeln in der Nähe von Oberflächen
EP2332645A1 (de) 1998-02-11 2011-06-15 The University Of Houston Vorrichtung zur Durchführung chemischer und biochemischer Reaktionen unter Anwendung von photoerzeugten Reagenzien
US7101914B2 (en) 1998-05-04 2006-09-05 Natural Asa Isomer enriched conjugated linoleic acid compositions
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
EP2273270A1 (de) 1998-08-28 2011-01-12 febit holding GmbH Verfahren und Vorrichtung zur Herstellung und/oder Analyse von biochemischen Reaktionsträgern
EP1125105A2 (de) * 1998-11-05 2001-08-22 ChemoMetec A/S Verfahren, gerät und system zur partikel-analyse
EP2175021B1 (de) 1999-02-19 2013-06-19 Synthetic Genomics, Inc. Verfahren zur Herstellung von Polymeren
AU4698600A (en) * 1999-05-05 2000-11-17 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
CA2379125C (en) * 1999-07-02 2009-04-07 Clondiag Chip Technologies Gmbh Microchip matrix device for duplicating and characterizing nucleic acids
JP2001078175A (ja) * 1999-07-07 2001-03-23 Fuji Photo Film Co Ltd 蛍光観察装置
JP2001070227A (ja) 1999-07-07 2001-03-21 Fuji Photo Film Co Ltd 蛍光観察装置
US6784982B1 (en) * 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US20050164293A1 (en) * 1999-11-29 2005-07-28 Peer Stahler Dynamic determination of analytes
DE19962803A1 (de) * 1999-12-23 2001-07-05 Basf Ag Verfahren und Vorrichtung zur maskenfreien Herstellung von Biopolymeren
DE10024132B4 (de) * 2000-01-28 2007-03-22 Leica Microsystems Cms Gmbh Anordnung zur Detektion von Fluoreszenzlicht mehrerer Probenpunkte
DE10013254A1 (de) 2000-03-17 2001-10-04 Friz Biochem Gmbh Vorrichtung und Verfahren zum Nachweis organischer Moleküle in einer Probensubstanz
AU5144901A (en) 2000-04-06 2001-10-23 Conlinco Inc Conjugated linoleic acid compositions
EP1274320A2 (de) 2000-04-18 2003-01-15 Natural AS Konjugiertes linoleinsäurepulver
DE10023423B4 (de) * 2000-05-12 2009-03-05 Gnothis Holding Sa Direkter Nachweis von Einzelmolekülen
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (es) 2000-06-21 2006-10-16 Bioarray Solutions Ltd Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
AU2001271893A1 (en) * 2000-07-07 2002-01-21 Nimblegen Systems, Inc. Method and apparatus for synthesis of arrays of dna probes
US6576472B1 (en) * 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
FR2813121A1 (fr) * 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
DE50107386D1 (de) * 2000-10-17 2005-10-13 Febit Ag Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger
DE10058095C2 (de) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Vorrichtung zur Bestimmung von Analyten durch Chemilumineszenz
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
DE10060433B4 (de) * 2000-12-05 2006-05-11 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zur Herstellung eines Fluidbauelements, Fluidbauelement und Analysevorrichtung
DE10062244A1 (de) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor zur Detektion von makromolekularen Biopolymeren, Sensoranordnung, Verfahren zur Detektion von makromolekularen Biopolymeren und Verfahren zum Herstellen eines Sensors zur Detektion von makromolekularen Biopolymeren
DE10103954B4 (de) * 2001-01-30 2005-10-06 Advalytix Ag Verfahren zur Analyse von Makromolekülen
DE10113711A1 (de) * 2001-03-16 2002-09-26 Lifebits Ag Verfahren zum Nachweis biochemischer Reaktionen und Messträger zur Durchführung des Verfahrens
DE10115474A1 (de) * 2001-03-29 2002-10-10 Infineon Technologies Ag Mikrofluidkanalstruktur und Verfahren zur Herstellung einer derartigen Mikrofluidkanalstruktur
WO2002078906A2 (en) * 2001-03-29 2002-10-10 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US20020160427A1 (en) * 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes
DE10122357A1 (de) * 2001-05-09 2002-11-14 Febit Ferrarius Biotech Gmbh Hybridverfahren zur Herstellung von Trägern für die Analytbestimmung
WO2002099397A2 (en) * 2001-06-06 2002-12-12 Digital Optical Imaging Corporation Light modulated microarray reader and methods relating thereto
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
DE10136008B4 (de) * 2001-07-24 2005-03-31 Advalytix Ag Verfahren zur Analyse von Makromolekülen und Verfahren zur Herstellung einer Analysevorrichtung
DE10142691B4 (de) * 2001-08-31 2006-04-20 Infineon Technologies Ag Verfahren zum Nachweis biochemischer Reaktionen sowie eine Vorrichtung hierfür
ATE470859T1 (de) 2001-09-06 2010-06-15 Straus Holdings Inc Schneller und empfindlicher nachweis von molekülen
DE10145700A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip-Anordnung, Sensor-Anordnung und Verfahren zum Betreiben einer Biochip-Anordnung
DE10145701A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Fluoreszenz-Biosensorchip und Fluoreszenz-Biosensorchip-Anordnung
DE10148102B4 (de) * 2001-09-28 2006-03-30 Biotez Berlin-Buch Gmbh Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen, seine Verwendung und Verfahren zum quantitativen Nachweis von Biomolekülen durch fotometrisches Erfassen einer Farbreaktion
DE10149947A1 (de) 2001-10-10 2003-04-17 Febit Ferrarius Biotech Gmbh Mikrofluidisches Extraktionsverfahren
CA2741049C (en) 2001-10-15 2019-02-05 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
DE10152925A1 (de) * 2001-10-26 2003-05-08 Febit Ag Asymmetrische Sonden
DE10155892A1 (de) * 2001-11-14 2003-05-28 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren und Biosensor zum Erfassen von makromolekularen Biopolymeren
US7413859B2 (en) 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
DE10156467A1 (de) * 2001-11-16 2003-06-05 Micronas Gmbh Träger zur Synthese sowie Verfahren zur Herstellung von Biopolymeren
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10160987B4 (de) 2001-12-05 2005-08-04 Siemens Ag Baueinheit zur simultanen, optischen Beleuchtung einer Vielzahl von Proben
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
DE10206548B4 (de) * 2002-02-13 2005-06-16 Siemens Ag Verfahren zur Analyse von Probenbestandteile tragenden Trägerplatten und Vorrichtungen zur Durchführung dieses Verfahrens
DE10208770A1 (de) * 2002-02-28 2003-09-04 Febit Ag Erhöhung der Sensitivität und Spezifität von Hybridisierungsexperimenten mit Nukleinsäure-Chips
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
DE10215319A1 (de) * 2002-04-02 2003-10-30 Siemens Ag Gerät zur Beleuchtung einer zu untersuchenden Probenplatte
JP2005526253A (ja) 2002-05-17 2005-09-02 アプレラ コーポレイション 励起波長による複数の蛍光シグナルを分化するための装置および方法
DE10224825A1 (de) * 2002-06-05 2003-12-24 Eppendorf Ag Verfahren zur Analyse von Biomolekülen
FR2842826B1 (fr) * 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
JP2004069559A (ja) 2002-08-07 2004-03-04 Seiko Epson Corp 製造システム、その制御装置、制御方法、制御システム及び制御プログラム
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
DE10242529A1 (de) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Meßsystem mit photoempfindlicher Elektrode
DE10242530A1 (de) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Lichtquelle für ein Meßsystem mit photoempfindlicher Elektrode zum Nachweis eines oder mehrerer Analyten
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US6743931B2 (en) 2002-09-24 2004-06-01 Natural Asa Conjugated linoleic acid compositions
DE10245432A1 (de) 2002-09-27 2004-04-08 Micronas Gmbh Verfahren und Vorrichtung zum Detektieren mindestens eines Lumineszenz-Stoffs
DE10245845B4 (de) * 2002-09-30 2006-06-29 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Meßchip für die Verwendung ein einer Vorrichtung zur quantitativen Bestimmung eines Analyten in einer Probe und Vorrichtung mit diesem Meßchip
US7305112B2 (en) * 2002-10-15 2007-12-04 The Scripps Research Institute Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media
US7220592B2 (en) 2002-11-15 2007-05-22 Eksigent Technologies, Llc Particulate processing system
US7175810B2 (en) 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
DE50310049D1 (de) * 2002-12-23 2008-08-07 Febit Biotech Gmbh Einbau von hapten-gruppen bei der herstellung von trägern für die analytbestimmung
WO2004058393A2 (de) * 2002-12-23 2004-07-15 Febit Biotech Gmbh Verfahren zum validierten aufbau von arrays
DE10312670A1 (de) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Substrat zur kontrollierten Benetzung vorbestimmter Benetzungsstellen mit kleinen Flüssigkeitsvolumina, Substratabdeckung und Flusskammer
EP1625386B8 (de) * 2003-03-24 2021-07-28 Intuity Medical, Inc. Vorrichtungen und verfahren zum nachweis von analytkonzentrationen
US7300755B1 (en) * 2003-05-12 2007-11-27 Fred Hutchinson Cancer Research Center Methods for haplotyping genomic DNA
JP2004361158A (ja) * 2003-06-03 2004-12-24 Moritex Corp 生化学検出装置及び検出方法
US8133670B2 (en) 2003-06-13 2012-03-13 Cold Spring Harbor Laboratory Method for making populations of defined nucleic acid molecules
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
US7718133B2 (en) * 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
CA2899287A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050209787A1 (en) * 2003-12-12 2005-09-22 Waggener Thomas B Sequencing data analysis
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
DE102004015272A1 (de) * 2004-03-29 2005-11-03 Infineon Technologies Ag Biosensor-Anordnung zum Erfassen von Biomolekülen und Verfahren zum Erfassen von Biomolekülen
DE102004021904B4 (de) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Verfahren und Vorrichtung zur Erzeugung einer Analyseanordnung mit diskreten, separaten Messbereichen zur biologischen, biochemischen oder chemischen Analyse
US7751048B2 (en) * 2004-06-04 2010-07-06 California Institute Of Technology Optofluidic microscope device
US7773227B2 (en) * 2004-06-04 2010-08-10 California Institute Of Technology Optofluidic microscope device featuring a body comprising a fluid channel and having light transmissive regions
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7522786B2 (en) * 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
US7291824B2 (en) * 2005-12-22 2007-11-06 Palo Alto Research Center Incorporated Photosensing throughout energy range and in subranges
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
DE102004056787A1 (de) * 2004-11-24 2006-06-01 Heinrich-Heine-Universität Düsseldorf Vorrichtung und Verfahren zur Messung von Fluoreszenz in mehreren Reaktionsräumen
TWI295730B (en) * 2004-11-25 2008-04-11 Ind Tech Res Inst Microfluidic chip for sample assay and method thereof
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
EP1872111A2 (de) 2005-04-19 2008-01-02 The President and Fellows of Harvard College Fluidische strukturen mit gewundenen und breiten kanälen
DE102005018337A1 (de) * 2005-04-20 2006-11-02 Micronas Gmbh Mikrooptisches Detektionssystem und Verfahren zur Bestimmung temperaturabhängiger Parameter von Analyten
GB0509833D0 (en) * 2005-05-16 2005-06-22 Isis Innovation Cell analysis
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
JP4607684B2 (ja) * 2005-06-29 2011-01-05 富士フイルム株式会社 流路ブロック、センサユニット、及び全反射減衰を利用した測定装置
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7760274B2 (en) 2005-12-08 2010-07-20 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array, apparatus for fabricating biomolecule array or polymer array including the programmable mask, and method of fabricating biomolecule array or polymer array using the programmable mask
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US7547904B2 (en) * 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460878B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
US9041938B2 (en) 2006-05-02 2015-05-26 California Institute Of Technology Surface wave assisted structures and systems
US7768654B2 (en) 2006-05-02 2010-08-03 California Institute Of Technology On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference
JP4431549B2 (ja) * 2006-05-31 2010-03-17 株式会社日立ハイテクノロジーズ 蛍光分析装置
US20120269728A1 (en) * 2006-08-02 2012-10-25 Antara Biosciences Inc. Methods and compositions for detecting one or more target agents using tracking components
DE102006039479A1 (de) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmierbare Oligonukleotidsynthese
WO2008049795A1 (en) * 2006-10-23 2008-05-02 Flexgen Bv Method and system for calibrating laser focus and position in micro-arrays
US7532128B2 (en) * 2006-10-25 2009-05-12 Alverix, Inc. Position sensitive indicator detection
DE102006056949B4 (de) * 2006-11-30 2011-12-22 Ruprecht-Karls-Universität Heidelberg Verfahren und Vorrichtung zur Detektion mindestens einer Eigenschaft von mindestens einem Objekt mit einem Mikrochip
DE102007018833A1 (de) 2007-04-20 2008-10-23 Febit Holding Gmbh Verbesserte molekularbiologische Prozessanlage
DE102006062089A1 (de) 2006-12-29 2008-07-03 Febit Holding Gmbh Verbesserte molekularbiologische Prozessanlage
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US7633629B2 (en) * 2007-02-05 2009-12-15 Palo Alto Research Center Incorporated Tuning optical cavities
US7936463B2 (en) * 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
US7852490B2 (en) * 2007-02-05 2010-12-14 Palo Alto Research Center Incorporated Implanting optical cavity structures
US7529438B2 (en) * 2007-07-13 2009-05-05 Palo Alto Research Center Incorporated Producing fluidic waveguides
US7522811B2 (en) * 2007-07-13 2009-04-21 Palo Alto Research Center Incorporated Producing sandwich waveguides
ES2488090T3 (es) * 2007-07-27 2014-08-26 F. Hoffmann-La Roche Ag Etiqueta de identificación de la orientación, estructura portadora de contenedores de reactivos y dispositivo analizador
ES2556627T3 (es) 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
DE102007054602A1 (de) * 2007-11-15 2009-05-28 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Messaufbau zum Erfassen der Verteilung mindestens einer Zustandsgröße in einem Messfeld mit verschiedenen Sonden
DE202007019582U1 (de) 2007-11-15 2014-01-30 Deutsches Zentrum für Luft- und Raumfahrt e.V. Messaufbau zum Erfassen der Verteilung mindestens einer Zustandsgröße in einem Messfeld mit verschiedenen Sonden
DE102007056398A1 (de) 2007-11-23 2009-05-28 Febit Holding Gmbh Flexibles Extraktionsverfahren für die Herstellung sequenzspezifischer Molekülbibliotheken
US8320983B2 (en) * 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US8373860B2 (en) 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
WO2009111577A1 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Methods of using optofluidic microscope devices
US8314933B2 (en) * 2008-03-04 2012-11-20 California Institute Of Technology Optofluidic microscope device with photosensor array
US8325349B2 (en) * 2008-03-04 2012-12-04 California Institute Of Technology Focal plane adjustment by back propagation in optofluidic microscope devices
DE102008021365A1 (de) * 2008-04-29 2009-01-22 Siemens Aktiengesellschaft Verfahren zum Einbringen von Reagenzien in Mikrokanäle einer Analyseeinheit
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
EP2340301A4 (de) 2008-09-24 2012-05-09 Straus Holdings Inc Bildgebungsanalysegerät zum testen von analyten
AU2009296405A1 (en) 2008-09-25 2010-04-01 The Trustees Of Columbia University In The City Of New York Devices, apparatus and method for providing photostimulation and imaging of structures
RU2385940C1 (ru) * 2008-10-23 2010-04-10 Общество с ограниченной ответственностью "ВИНТЕЛ" Способ определения нуклеиновых кислот методом полимеразно-цепной реакции в режиме реального времени и устройство для его осуществления
US8660312B2 (en) * 2009-01-21 2014-02-25 California Institute Of Technology Quantitative differential interference contrast (DIC) devices for computed depth sectioning
US20100216648A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
WO2010106109A1 (en) 2009-03-17 2010-09-23 Febit Holding Gmbh Multi-use of biochips
DE102009014080B4 (de) * 2009-03-23 2011-12-15 Baumer Innotec Ag Vorrichtung zum Bestimmen von Partikelgrössen
FR2943789B1 (fr) * 2009-03-26 2013-07-26 Commissariat Energie Atomique Procede et dispositif pour la caracterisation de la dynamique de coagulation ou sedimentation d'un fluide tel que le sang ou le plasma sanguin
KR20100109196A (ko) * 2009-03-31 2010-10-08 삼성전자주식회사 빛의 투과량 또는 반사량을 이용한 검출 대상물의 농도 측정시스템 및 방법
US8300971B2 (en) * 2009-04-17 2012-10-30 LevelSet Systems, Inc. Method and apparatus for image processing for massive parallel DNA sequencing
US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
US8633432B2 (en) * 2009-09-21 2014-01-21 California Institute Of Technology Reflective focusing and transmissive projection device
CN101698146B (zh) * 2009-09-24 2011-10-26 复旦大学附属肿瘤医院 用于合成放射性药物的微量反应器及其应用
JP5012873B2 (ja) * 2009-10-14 2012-08-29 カシオ計算機株式会社 画像処理装置
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
CA2778725C (en) 2009-10-28 2019-04-30 Alentic Microscience Inc. Microscopy imaging
WO2011054614A1 (en) * 2009-11-05 2011-05-12 Waterford Institute Of Technology A nanohole array biosensor
ES2544635T3 (es) * 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011119678A2 (en) * 2010-03-23 2011-09-29 California Institute Of Technology Super resolution optofluidic microscopes for 2d and 3d imaging
DE102010018678B4 (de) 2010-04-28 2017-06-29 Sartorius Stedim Biotech Gmbh Bioreaktoranordnung, Schüttelvorrichtung und Verfahren zum Bestrahlen eines Mediums in einem Bioreaktor
SE535918C2 (sv) * 2010-06-10 2013-02-19 Hemocue Ab Detektion av magnetiskt inmärkta biologiska komponenter
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
WO2012030995A2 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Optical system for high resolution thermal melt detection
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9643184B2 (en) 2010-10-26 2017-05-09 California Institute Of Technology e-Petri dishes, devices, and systems having a light detector for sampling a sequence of sub-pixel shifted projection images
US9569664B2 (en) 2010-10-26 2017-02-14 California Institute Of Technology Methods for rapid distinction between debris and growing cells
CN103154662A (zh) 2010-10-26 2013-06-12 加州理工学院 扫描投影无透镜显微镜系统
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
CN103534627A (zh) 2011-03-03 2014-01-22 加州理工学院 光导像素
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US9117149B2 (en) 2011-10-07 2015-08-25 Industrial Technology Research Institute Optical registration carrier
DK3327110T3 (en) 2011-11-07 2020-04-27 Rapid Micro Biosystems Inc Kassette til sterilitetstest
KR20130073354A (ko) * 2011-12-23 2013-07-03 한국전자통신연구원 바이오 칩 분석 장치
CN104364388B (zh) 2012-04-16 2017-12-19 快速微型生物系统公司 细胞培养装置
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
DE102013106432A1 (de) * 2013-06-20 2014-12-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Optische Indikator-Einheit und Vorrichtung und Verfahren zur Bestimmung einer physikalisch-chemischen Eigenschaft eines Prozessmediums in einer prozesstechnischen Anlage
CN105765440B (zh) 2013-06-26 2020-08-18 阿兰蒂克微科学股份有限公司 用于显微的样品处理改进装置及方法
TWI805996B (zh) 2013-08-05 2023-06-21 美商扭轉生物科技有限公司 重新合成之基因庫
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
DE102015003019A1 (de) * 2015-03-06 2016-09-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur optischen Detektion einer Bewegung in einer biologischen Probe mit räumlicher Ausdehnung
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3104208B1 (de) * 2015-06-09 2022-08-24 Nokia Technologies Oy Elektrisches schaltkreis zur ventilsteuerung zur übertragungssteuerung einer optisch aktiven flüssigkeit von einem ersten reservoir zu einem zweiten reservoir
US10444152B2 (en) 2015-07-10 2019-10-15 Yamato Scientific Co., Ltd. Tissue sample analysis device and tissue sample analysis system
JP6239562B2 (ja) 2015-09-14 2017-11-29 株式会社東芝 照明デバイスおよびそれを備えるバイオ情報計測装置
US10844373B2 (en) 2015-09-18 2020-11-24 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
KR20180058772A (ko) 2015-09-22 2018-06-01 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
US9895673B2 (en) 2015-12-01 2018-02-20 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
CN106248764B (zh) * 2016-08-03 2020-03-24 南京山诺生物科技有限公司 一种实时可视共享及一体成像的核酸电泳装置及其操作方法
CA3034769A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
KR20180046098A (ko) * 2016-10-27 2018-05-08 삼성전자주식회사 검사장치, 검사 시스템 및 검사장치의 제어방법
KR102514213B1 (ko) 2016-12-16 2023-03-27 트위스트 바이오사이언스 코포레이션 면역 시냅스의 변이체 라이브러리 및 그의 합성
EP3586255A4 (de) 2017-02-22 2021-03-31 Twist Bioscience Corporation Nukleinsäurebasierte datenspeicherung
CN110913865A (zh) 2017-03-15 2020-03-24 特韦斯特生物科学公司 免疫突触的变体文库及其合成
SG11201912057RA (en) 2017-06-12 2020-01-30 Twist Bioscience Corp Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
US10894242B2 (en) 2017-10-20 2021-01-19 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
DE102017127671A1 (de) * 2017-11-23 2019-05-23 Osram Opto Semiconductors Gmbh Photonischer Gassensor und Verfahren zur Herstellung eines photonischen Gassensors
KR20200106067A (ko) 2018-01-04 2020-09-10 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
WO2019222706A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11684903B2 (en) 2018-10-24 2023-06-27 Daniel Shafer Microscale chemical reactors
CN109289725A (zh) * 2018-11-14 2019-02-01 山东金德新材料有限公司 一种新型微通道反应器
WO2020127828A1 (de) * 2018-12-21 2020-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung, vermessungssystem und verfahren zur erfassung einer zumindest teilweise spiegelnden oberfläche unter verwendung zweier spiegelungsmuster
CA3131689A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
CN113785057A (zh) 2019-02-26 2021-12-10 特韦斯特生物科学公司 用于抗体优化的变异核酸文库
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
DE102020123949A1 (de) 2020-09-15 2022-03-17 IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH (IMMS GmbH) Elektrochemische Sensoranordnung und Verwendung eines fotoelektrischen Sensors zur Bestimmung von Ladungsträgern in einem Medium
WO2023187429A1 (en) * 2022-03-31 2023-10-05 Thalesnano Zrt Flow-through type apparatus for performing chemical reaction of reagents principally in space

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318679A (en) * 1991-08-07 1994-06-07 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
WO1998008085A1 (en) * 1996-08-22 1998-02-26 Science Applications International Corporation Automatic sequencer/genotyper having extended spectral response
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection
WO1999041007A2 (en) * 1998-02-11 1999-08-19 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
WO1999042813A1 (en) * 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
WO1999060156A2 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren und vorrichtung zur photolithographischen herstellung von dna, pna und protein chips
WO1999063385A1 (en) * 1998-06-04 1999-12-09 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1107714A (en) * 1964-04-18 1968-03-27 Dowty Technical Dev Ltd Hydraulic power transmission
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3301833A1 (de) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
DE8309254U1 (de) 1983-03-29 1985-01-03 Straub, Hans, Dipl.-Ing.(FH), 7345 Deggingen Verteilereinheit fuer die rohre von zentralheizungsanlagen
DE3322373C2 (de) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
SE8303626D0 (sv) 1983-06-23 1983-06-23 Kabigen Ab A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced
AU581669B2 (en) * 1984-06-13 1989-03-02 Applied Research Systems Ars Holding N.V. Photometric instruments, their use in methods of optical analysis, and ancillary devices therefor
EP0316018A3 (de) 1985-03-29 1989-07-26 Cetus Oncology Corporation Modifikation von DNS-Sequenzen
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
GB8714270D0 (en) * 1987-06-18 1987-07-22 Williams G R Analysis of carbohydrates
US5162863A (en) * 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
EP0427745A4 (en) 1988-07-14 1992-11-25 Baylor College Of Medicine Solid phase assembly and reconstruction of biopolymers
EP0385410B1 (de) 1989-02-28 1996-10-02 Canon Kabushiki Kaisha Partiell doppelsträngiges Oligonukleotid und Verfahren zu seiner Bildung
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
FR2652423B1 (fr) 1989-09-22 1992-05-22 Ardt Rgle Dev Techn Procede de microlithographie pour la realisation de structures superficielles submicrometriques sur un substrat du type d'une plaquette de silicium, ainsi qu'un dispositif le mettant en óoeuvre.
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
WO1991018276A1 (en) 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
ATE244065T1 (de) 1990-12-06 2003-07-15 Affymetrix Inc Verfahren und reagenzien für immobilisierten polymersynthese in sehr grossem masstab
EP0493137B1 (de) 1990-12-28 1998-09-23 Research Development Corporation of Japan Verfahren zur Bildung ultrafeiner Strukturen
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5239176A (en) * 1991-10-03 1993-08-24 Foster-Miller, Inc. Tapered optical fiber sensing attenuated total reflectance
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
DE69233331T3 (de) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Kombinatorische Strategien zur Polymersynthese
US5247180A (en) 1991-12-30 1993-09-21 Texas Instruments Incorporated Stereolithographic apparatus and method of use
US5258295A (en) * 1992-02-25 1993-11-02 Glyko, Inc. Fluorophore-assisted cloning analysis
GB9206671D0 (en) 1992-03-27 1992-05-13 Cranfield Biotech Ltd Electrochemical detection of dna hybridisation
ATE463744T1 (de) * 1992-09-14 2010-04-15 Stanford Res Inst Int Hochkonvertierende reportermoleküle für biologische und andere testverfahren unter verwendung von laseranregungstechniken
WO1994012632A1 (en) 1992-11-27 1994-06-09 University College London Improvements in nucleic acid synthesis by pcr
DE4241871A1 (de) 1992-12-11 1994-06-16 Schulz Rudolf Ing Grad Molekularer Computer durch atomare Chips in Verbindung mit optischem Transistor sowie assoziativen Speichern
US5368823A (en) 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
WO1995001559A2 (de) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Probenträger und seine verwendung
DE4325724A1 (de) 1993-07-30 1995-02-02 Paul Dr Debbage Vorrichtung und Verfahren zur Untersuchung eines Objektes und zur Einwirkung auf das Objekt
WO1995009176A1 (en) 1993-09-28 1995-04-06 Beckman Instruments, Inc. Biopolymer synthesis utilizing surface activated, organic polymers
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
EP0671626B1 (de) 1994-03-08 2000-01-12 Zeptosens AG Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
JP3215428B2 (ja) * 1995-01-16 2001-10-09 ソイニ，エルッキ 生物特異性マルチパラメーターアッセイ法
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
HUP9801679A3 (en) 1995-03-10 2001-01-29 Meso Scale Technologies Llc Co Process and agent for multi-array, multi-specific electrochemiluminescence testing
US5736257A (en) 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5582705A (en) 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
AU6752496A (en) 1995-07-28 1997-03-05 Ely Michael Rabani Pattern formation, replication, fabrication and devices thereby
US5807525A (en) 1995-08-17 1998-09-15 Hybridon, Inc. Apparatus and process for multi stage solid phase synthesis of long chained organic molecules
US5723320A (en) 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5728251A (en) 1995-09-27 1998-03-17 Research Frontiers Inc Light modulating film of improved UV stability for a light valve
US5667195A (en) * 1995-11-13 1997-09-16 Matthew Howard McCormick Fluid drain apparatus
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
JP3233851B2 (ja) 1996-04-24 2001-12-04 繁織 竹中 遺伝子の電気化学的検出法およびその装置
DE69719817T2 (de) 1996-04-25 2003-12-24 Pence Inc Biosensor-vorrichtung und verfahren
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
DE69734247T2 (de) 1996-07-19 2006-06-22 The Regents Of The University Of Michigan, Ann Arbor Für den von willebrand faktor der hunde kodierende dna und verfahren zu ihrer verwendung
GB9621122D0 (en) * 1996-10-10 1996-11-27 Cambridge Imaging Ltd Improvements in and relating to methods and apparatus for assay analysis
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
IES80556B2 (en) 1997-01-10 1998-09-23 Robert Arpad Foster Electrochemical diagnostic detection device
US5812272A (en) 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
AU756945B2 (en) 1997-05-23 2003-01-30 Bioarray Solutions Ltd Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
DE19726634A1 (de) 1997-06-18 1998-12-24 Biotools Inst Fuer Computerint Verfahren und Vorrichtung zur Immobilisierung von Makromolekülen
JP2001515216A (ja) 1997-08-13 2001-09-18 シーフィード 流体試料を操作するための微小構造体
JP3938982B2 (ja) * 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
EP1015576B1 (de) 1997-09-16 2005-05-04 Egea Biosciences, LLC Methoden zur kompletten chemischen synthese und zusammensetzung von genen und genomen
US6548021B1 (en) 1997-10-10 2003-04-15 President And Fellows Of Harvard College Surface-bound, double-stranded DNA protein arrays
US6177558B1 (en) 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US20020076735A1 (en) * 1998-09-25 2002-06-20 Williams Lewis T. Diagnostic and therapeutic methods using molecules differentially expressed in cancer cells
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
JP2002502588A (ja) 1998-02-06 2002-01-29 アフィメトリックス インコーポレイテッド 製造プロセスにおける品質管理の方法
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
WO1999060170A1 (en) 1998-05-21 1999-11-25 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
DE19823876B4 (de) 1998-05-28 2004-07-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mit unterschiedlichen Verbindungen beladenes Bauteil (Biochip) sowie Verfahren zu dessen Herstellung
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
EP2273270A1 (de) 1998-08-28 2011-01-12 febit holding GmbH Verfahren und Vorrichtung zur Herstellung und/oder Analyse von biochemischen Reaktionsträgern
DE19842164B4 (de) 1998-09-15 2004-06-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur Qualitätskontrolle beim Aufbau von Oligomerrastern
DE19921940C2 (de) 1998-11-23 2003-02-06 Friz Biochem Gmbh Verfahren zur elektrochemischen Detektion von Nukleinsäureoligomerhybriden
DE19964220C2 (de) 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
HUP0105170A3 (en) 1999-01-18 2005-03-29 Friz Biochem Gmbh Method for electrochemically detecting nucleic acid-oligomer hybridisation events
DE19901761A1 (de) 1999-01-18 1999-07-01 Gerhard Dr Hartwich Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
EP2175021B1 (de) 1999-02-19 2013-06-19 Synthetic Genomics, Inc. Verfahren zur Herstellung von Polymeren
DE19910392B4 (de) 1999-03-05 2005-03-17 Clondiag Chip Technologies Gmbh Mikrosäulenreaktor
DE60020340T2 (de) 1999-03-08 2006-03-16 Metrigen, Inc., Burlingame Syntheseverfahren zum ökonomischen aufbau langer dna-sequenzen und zusammensetzungen hierfür
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
DE50107386D1 (de) 2000-10-17 2005-10-13 Febit Ag Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger
US20020160427A1 (en) 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5318679A (en) * 1991-08-07 1994-06-07 H & N Instruments, Inc. Synthesis of chain chemical compounds
WO1998008085A1 (en) * 1996-08-22 1998-02-26 Science Applications International Corporation Automatic sequencer/genotyper having extended spectral response
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection
WO1999041007A2 (en) * 1998-02-11 1999-08-19 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
WO1999042813A1 (en) * 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
WO1999060156A2 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren und vorrichtung zur photolithographischen herstellung von dna, pna und protein chips
WO1999063385A1 (en) * 1998-06-04 1999-12-09 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"DIGITAL OPTICAL CHEMISTRY", XP002126303, Retrieved from the Internet <URL:http://pompous.swmed.edu/exptbio/doc/> [retrieved on 19991220] *
CHEMICAL ABSTRACTS, vol. 127, no. 15, 13 October 1997, Columbus, Ohio, US; abstract no. 212440, BERTSCH, A. ET AL: "Study of the spatial resolution of a new 3D microfabrication process: the microstereophotolithog. using a dynamic mask-generator technique" XP002123247 *
CHEMICAL ABSTRACTS, vol. 127, no. 15, 13 October 1997, Columbus, Ohio, US; abstract no. 212440, BERTSCH, A. ET AL: "Study of the spatial resolution of a new 3D microfabrication process: the microstereophotolithog. using a dynamic mask-generator technique" XP002126306 *
DATABASE INSPEC [online] INSTITUTE OF ELECTRICAL ENGINEERS, STEVENAGE, GB; DAVIDSON M: "A microlens direct-write concept for lithography", XP002126304, Database accession no. 5762686 *
EMERGING LITHOGRAPHIC TECHNOLOGIES, vol. 3048, Proceedings of the SPIE - The International Society for Optical Engineering, 1997, SPIE-Int. Soc. Opt. Eng, USA, pages 346 - 355, ISSN: 0277-786X *
J. PHOTOCHEM. PHOTOBIOL., A (1997), 107(1-3), 275-281, 1997 *
R. COLIN JOHNSON: "Micromirror arrays perform photolithography step", EETTIMES.COM, 20 December 1999 (1999-12-20), us, XP002126302, Retrieved from the Internet <URL:http://eet.com/story/technology/advanced/OEG19991012S0043> [retrieved on 19991220] *
SANGEET SINGH-GASSON ET AL.: "Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array", NATURE BIOTECHNOLOGY., vol. 17, October 1999 (1999-10-01), NATURE PUBLISHING., US, pages 974 - 978, XP002126301, ISSN: 1087-0156 *

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