WO1999052469A9 - Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger - Google Patents
Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavengerInfo
- Publication number
- WO1999052469A9 WO1999052469A9 PCT/US1999/007912 US9907912W WO9952469A9 WO 1999052469 A9 WO1999052469 A9 WO 1999052469A9 US 9907912 W US9907912 W US 9907912W WO 9952469 A9 WO9952469 A9 WO 9952469A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fumarate
- poly
- molecular weight
- polydispersity index
- average molecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
- C08G63/56—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds other than from esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT99915349T ATE291444T1 (en) | 1998-04-10 | 1999-04-09 | SYNTHESIS OF POLY(PROPYLENE NFUMARATE) BY ACETYLATION OF PROPYLENE GLYCOL IN THE PRESENCE OF A PROTON CAPTURER |
EP99915349A EP1079869B1 (en) | 1998-04-10 | 1999-04-09 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
JP2000543082A JP2002539275A (en) | 1998-04-10 | 1999-04-09 | Synthesis of poly (propylene fumarate) by acylation of propylene glycol in the presence of proton scavenger |
DE69924369T DE69924369D1 (en) | 1998-04-10 | 1999-04-09 | SYNTHESIS OF POLY (PROPYLENE FUMARATE) BY ACETYLATION OF PROPYLENE GLYCOL IN THE PRESENCE OF A PROTONATE FENDER |
CA002327730A CA2327730A1 (en) | 1998-04-10 | 1999-04-09 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
US09/678,816 US6355755B1 (en) | 1998-04-10 | 2000-10-04 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8130898P | 1998-04-10 | 1998-04-10 | |
US8140598P | 1998-04-10 | 1998-04-10 | |
US60/081,405 | 1998-04-10 | ||
US60/081,308 | 1998-04-10 | ||
US8218298P | 1998-04-16 | 1998-04-16 | |
US60/082,182 | 1998-04-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/678,816 Continuation US6355755B1 (en) | 1998-04-10 | 2000-10-04 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999052469A1 WO1999052469A1 (en) | 1999-10-21 |
WO1999052469A9 true WO1999052469A9 (en) | 2000-03-23 |
Family
ID=27373944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/007912 WO1999052469A1 (en) | 1998-04-10 | 1999-04-09 | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
Country Status (7)
Country | Link |
---|---|
US (2) | US6124373A (en) |
EP (1) | EP1079869B1 (en) |
JP (1) | JP2002539275A (en) |
AT (1) | ATE291444T1 (en) |
CA (1) | CA2327730A1 (en) |
DE (1) | DE69924369D1 (en) |
WO (1) | WO1999052469A1 (en) |
Families Citing this family (46)
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US6486232B1 (en) * | 1997-04-18 | 2002-11-26 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements |
US6124373A (en) | 1998-04-10 | 2000-09-26 | Wm. Marsh Rice University | Bone replacement compound comprising poly(polypropylene fumarate) |
WO2000063268A1 (en) | 1999-04-16 | 2000-10-26 | Wm. Marsh Rice University | Poly(propylene fumarate) cross linked with poly(ethylene glycol) |
US6884778B2 (en) * | 2000-04-14 | 2005-04-26 | William Marsh Rice University | Biocompatible macromers |
DE10032220A1 (en) * | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium ammonium phosphate cements, their manufacture and use |
AU2002305201A1 (en) * | 2001-04-19 | 2002-11-05 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
EP1409566B1 (en) * | 2001-06-28 | 2008-04-23 | Wm. MARSH RICE UNIVERSITY | Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials |
US7629388B2 (en) | 2001-11-20 | 2009-12-08 | William Marsh Rice University | Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion |
US20030180344A1 (en) * | 2002-02-05 | 2003-09-25 | Cambridge Scientific, Inc. | Bioresorbable osteoconductive compositions for bone regeneration |
US6884432B2 (en) * | 2002-04-25 | 2005-04-26 | Mayo Foundation For Medical Education And Research | Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery |
US7273523B2 (en) * | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
WO2004082524A2 (en) * | 2003-03-13 | 2004-09-30 | William Marsh Rice University | Composite injectable and pre-fabricated bone replacement material and method for the production of such bone replacement material |
US20060264967A1 (en) | 2003-03-14 | 2006-11-23 | Ferreyro Roque H | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
WO2006011152A2 (en) * | 2004-06-17 | 2006-02-02 | Disc-O-Tech Medical Technologies, Ltd. | Methods for treating bone and other tissue |
WO2005004811A2 (en) * | 2003-07-01 | 2005-01-20 | Mayo Foundation For Medical Education And Research | Self-crosslinkable poly(caprolactone fumarate) |
US7252686B2 (en) * | 2003-08-13 | 2007-08-07 | Boston Scientific Scimed | Methods for reducing bone compression fractures using wedges |
WO2005030034A2 (en) | 2003-09-26 | 2005-04-07 | Depuy Spine, Inc. | Device for delivering viscous material |
US20060018949A1 (en) * | 2004-04-07 | 2006-01-26 | Bausch & Lomb Incorporated | Injectable biodegradable drug delivery system |
ES2396133T3 (en) | 2004-04-27 | 2013-02-19 | Kyphon SÀRl | Bone replacement compositions and method of use |
CA2587308A1 (en) | 2004-11-12 | 2006-05-18 | Mayo Foundation For Medical Education And Research | Photocrosslinkable poly(caprolactone fumarate) |
WO2006055940A2 (en) * | 2004-11-18 | 2006-05-26 | Mayo Foundation For Medical Education And Research | Block copolymers of polycaprolactone and poly (propylene fumarate) |
AU2006242487B2 (en) * | 2005-04-29 | 2011-12-01 | Mayo Foundation For Medical Education And Research | Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US8360629B2 (en) | 2005-11-22 | 2013-01-29 | Depuy Spine, Inc. | Mixing apparatus having central and planetary mixing elements |
US7754005B2 (en) * | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
ES2547854T3 (en) * | 2006-06-29 | 2015-10-09 | Depuy Spine, Inc. | Integrated bone biopsy and therapy device |
WO2008032322A2 (en) | 2006-09-14 | 2008-03-20 | Depuy Spine, Inc. | Bone cement and methods of use thereof |
AU2007300585A1 (en) * | 2006-09-21 | 2008-04-03 | Kyphon Sarl | Diammonium phosphate and other ammonium salts and their use in preventing clotting |
AU2007311451A1 (en) | 2006-10-19 | 2008-04-24 | Depuy Spine, Inc. | Fluid delivery system |
US20080195223A1 (en) * | 2006-11-03 | 2008-08-14 | Avram Allan Eddin | Materials and Methods and Systems for Delivering Localized Medical Treatments |
PT2022446E (en) * | 2007-07-30 | 2012-07-04 | Purzer Pharmaceutical Co Ltd | Bio-degenerable bone cement and manufacturing method thereof |
US20090286907A1 (en) * | 2008-01-23 | 2009-11-19 | Beltz Mark W | Fumaric Acid/Diol Polyesters and Their Manufacture and Use |
US7968616B2 (en) * | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
WO2012005783A1 (en) | 2010-07-09 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Biodegradable scaffolds |
CN103379924B (en) | 2010-08-20 | 2015-07-29 | 凯斯西储大学 | Manufacture is added in the continuous number optical processing of implant |
US11865785B2 (en) * | 2010-08-20 | 2024-01-09 | H. David Dean | Continuous digital light processing additive manufacturing of implants |
US10293079B2 (en) | 2014-05-05 | 2019-05-21 | Sealantis Ltd. | Biological adhesives and sealants and methods of using the same |
AU2015349988B2 (en) * | 2014-11-18 | 2019-08-01 | The Ohio State University | Well-defined degradable poly(propylene fumarate) polymers and scalable methods for the synthesis thereof |
CN110366434B (en) | 2017-02-02 | 2022-04-05 | 阿克伦大学 | Functionalized poly (propylene fumarate) polymers prepared by ring opening polymerization using magnesium catalysts |
GB2594243A (en) * | 2020-04-15 | 2021-10-27 | Arterius Ltd | A bone cement |
WO2022015989A1 (en) * | 2020-07-15 | 2022-01-20 | The University Of Akron | Synthesis of poly (propylene maleate-co-succinate) by the time-dependent reduction of poly (propylene maleate) double bonds mediated by zinc and acetic acid |
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NZ235372A (en) | 1989-10-10 | 1992-05-26 | Wrigley W M Jun Co | Slow release delivery system made by fibre melt spinning techniques producing a fibre about 1mm diameter, exterior is substantially wall material and core mostly active agent dispersed through the fibre material which is porous overall |
FR2661682B1 (en) | 1990-05-04 | 1993-12-10 | Norsolor | NEW RESINOUS COMPOSITIONS BASED ON UNSATURATED POLYESTER RESINS AND NEW ANTI-SHRINKAGE ADDITIVES. |
JP3011768B2 (en) | 1992-02-28 | 2000-02-21 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Photopolymerizable biodegradable hydrophilic gels as tissue contacting materials and controlled release carriers |
US5733951A (en) * | 1994-04-28 | 1998-03-31 | Yaszemski; Michael J. | Poly(propylene fumarate) |
US5527864A (en) * | 1995-08-08 | 1996-06-18 | Suggs; Laura J. | Poly(propylene fumarate-co-ethylene oxide) |
US5946457A (en) | 1995-12-25 | 1999-08-31 | Sharp Kabushiki Kaisha | Image forming system having transfer device for communicating between image forming apparatus and image processing apparatus |
US5998362A (en) | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6071982A (en) | 1997-04-18 | 2000-06-06 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same |
US5854382A (en) | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
US6124373A (en) | 1998-04-10 | 2000-09-26 | Wm. Marsh Rice University | Bone replacement compound comprising poly(polypropylene fumarate) |
-
1999
- 1999-04-09 US US09/289,361 patent/US6124373A/en not_active Expired - Lifetime
- 1999-04-09 WO PCT/US1999/007912 patent/WO1999052469A1/en active IP Right Grant
- 1999-04-09 JP JP2000543082A patent/JP2002539275A/en active Pending
- 1999-04-09 CA CA002327730A patent/CA2327730A1/en not_active Abandoned
- 1999-04-09 EP EP99915349A patent/EP1079869B1/en not_active Expired - Lifetime
- 1999-04-09 DE DE69924369T patent/DE69924369D1/en not_active Expired - Fee Related
- 1999-04-09 AT AT99915349T patent/ATE291444T1/en not_active IP Right Cessation
-
2000
- 2000-10-04 US US09/678,816 patent/US6355755B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2327730A1 (en) | 1999-10-21 |
ATE291444T1 (en) | 2005-04-15 |
JP2002539275A (en) | 2002-11-19 |
WO1999052469A1 (en) | 1999-10-21 |
EP1079869A1 (en) | 2001-03-07 |
US6124373A (en) | 2000-09-26 |
US6355755B1 (en) | 2002-03-12 |
EP1079869B1 (en) | 2005-03-23 |
DE69924369D1 (en) | 2005-04-28 |
EP1079869A4 (en) | 2002-08-07 |
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