WO1999043713A1 - Enhancing the circulating half-life of antibody-based fusion proteins - Google Patents
Enhancing the circulating half-life of antibody-based fusion proteins Download PDFInfo
- Publication number
- WO1999043713A1 WO1999043713A1 PCT/US1999/003966 US9903966W WO9943713A1 WO 1999043713 A1 WO1999043713 A1 WO 1999043713A1 US 9903966 W US9903966 W US 9903966W WO 9943713 A1 WO9943713 A1 WO 9943713A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibody
- fusion protein
- protein
- based fusion
- heavy chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000533463A JP2002505086A (en) | 1998-02-25 | 1999-02-24 | Enhanced circulating half-life of antibody-based fusion proteins |
CA002320403A CA2320403A1 (en) | 1998-02-25 | 1999-02-24 | Enhancing the circulating half-life of antibody-based fusion proteins |
AU27842/99A AU758240B2 (en) | 1998-02-25 | 1999-02-24 | Enhancing the circulating half-life of antibody-based fusion proteins |
BR9908226-8A BR9908226A (en) | 1998-02-25 | 1999-02-24 | Improvement of the circulating half-life of fusion proteins based on antibody |
PL342497A PL199659B1 (en) | 1998-02-25 | 1999-02-24 | Antibody-based fusion protein featured by prolonged residence in a cireculatory system and method of prolonging its residence time in a circulatory system |
HU0100813A HUP0100813A3 (en) | 1998-02-25 | 1999-02-24 | Enhancing the circulating half-life of antibody-based fusion proteins |
EP99908399A EP1060194A1 (en) | 1998-02-25 | 1999-02-24 | Enhancing the circulating half-life of antibody-based fusion proteins |
NO20004218A NO20004218L (en) | 1998-02-25 | 2000-08-23 | Increasing the circulating half-life of an antibody-based fusion protein |
HK01107082A HK1036286A1 (en) | 1998-02-25 | 2001-10-09 | Enhancing the circulating half-life of antibody-based fusion proteins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7588798P | 1998-02-25 | 1998-02-25 | |
US60/075,887 | 1998-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999043713A1 true WO1999043713A1 (en) | 1999-09-02 |
Family
ID=22128576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/003966 WO1999043713A1 (en) | 1998-02-25 | 1999-02-24 | Enhancing the circulating half-life of antibody-based fusion proteins |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1060194A1 (en) |
JP (1) | JP2002505086A (en) |
CN (1) | CN1204147C (en) |
AU (1) | AU758240B2 (en) |
BR (1) | BR9908226A (en) |
CA (1) | CA2320403A1 (en) |
CZ (1) | CZ20003099A3 (en) |
HK (1) | HK1036286A1 (en) |
HU (1) | HUP0100813A3 (en) |
NO (1) | NO20004218L (en) |
PL (1) | PL199659B1 (en) |
WO (1) | WO1999043713A1 (en) |
Cited By (122)
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WO2001032714A1 (en) * | 1999-11-03 | 2001-05-10 | King's College London | Recombinant fusion molecules |
US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
WO2001058957A2 (en) * | 2000-02-11 | 2001-08-16 | Lexigen Pharmaceuticals Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
WO2002022680A3 (en) * | 2000-09-15 | 2002-09-12 | Klaus Pfizenmaier | Site-specific, antibody-mediated activation of proapoptotic cytokine: amaice (antibody-mediated apoptosis inducing cytokine) |
WO2002072605A2 (en) * | 2001-03-07 | 2002-09-19 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
WO2002060919A3 (en) * | 2000-12-12 | 2003-09-04 | Medimmune Inc | Molecules with extended half-lives, compositions and uses thereof |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
EP1446157A2 (en) * | 2001-10-29 | 2004-08-18 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
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US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7355008B2 (en) | 2003-01-09 | 2008-04-08 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
US7371826B2 (en) | 1999-01-15 | 2008-05-13 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7416726B2 (en) | 2000-04-13 | 2008-08-26 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
WO2008118093A1 (en) * | 2007-03-28 | 2008-10-02 | Astrazeneca Ab | Fusion protein capable of degrading amyloid beta peptide |
WO2009092011A1 (en) | 2008-01-18 | 2009-07-23 | Medimmune, Llc | Cysteine engineered antibodies for site-specific conjugation |
AU2003286467B2 (en) * | 2002-10-15 | 2009-10-01 | Abbvie Biotherapeutics Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
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AU2004231078B2 (en) * | 2003-04-10 | 2011-06-09 | Abbvie Biotherapeutics Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
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WO2014023752A1 (en) * | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
AU2014200579A1 (en) * | 2000-12-12 | 2014-02-20 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
WO2014029752A1 (en) | 2012-08-22 | 2014-02-27 | Glaxo Group Limited | Anti lrp6 antibodies |
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US8907066B2 (en) | 2009-04-22 | 2014-12-09 | Merck Patent Gmbh | Antibody fusion proteins with a modified FcRn binding site |
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JP2005073528A (en) * | 2003-08-28 | 2005-03-24 | Genetics Inst Llc | Method for inhibiting adhesion of blood to biological tissue in biological system, and composition for being used for the method |
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GB201506393D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
EP3929212A4 (en) * | 2019-02-22 | 2022-11-23 | Wuhan Yzy Biopharma Co., Ltd. | Modified fc fragment, antibody comprising same, and application thereof |
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-
1999
- 1999-02-24 JP JP2000533463A patent/JP2002505086A/en active Pending
- 1999-02-24 PL PL342497A patent/PL199659B1/en not_active IP Right Cessation
- 1999-02-24 CN CN99803277.8A patent/CN1204147C/en not_active Expired - Fee Related
- 1999-02-24 WO PCT/US1999/003966 patent/WO1999043713A1/en active IP Right Grant
- 1999-02-24 EP EP99908399A patent/EP1060194A1/en not_active Ceased
- 1999-02-24 BR BR9908226-8A patent/BR9908226A/en not_active Application Discontinuation
- 1999-02-24 CZ CZ20003099A patent/CZ20003099A3/en unknown
- 1999-02-24 AU AU27842/99A patent/AU758240B2/en not_active Ceased
- 1999-02-24 HU HU0100813A patent/HUP0100813A3/en unknown
- 1999-02-24 CA CA002320403A patent/CA2320403A1/en not_active Abandoned
-
2000
- 2000-08-23 NO NO20004218A patent/NO20004218L/en not_active Application Discontinuation
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CN1291995A (en) | 2001-04-18 |
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NO20004218L (en) | 2000-10-24 |
AU2784299A (en) | 1999-09-15 |
CZ20003099A3 (en) | 2002-04-17 |
EP1060194A1 (en) | 2000-12-20 |
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CA2320403A1 (en) | 1999-09-02 |
AU758240B2 (en) | 2003-03-20 |
JP2002505086A (en) | 2002-02-19 |
HUP0100813A2 (en) | 2001-06-28 |
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