WO1999038545A1 - Lubricious hydrophilic coating for an intracorporeal medical device - Google Patents
Lubricious hydrophilic coating for an intracorporeal medical device Download PDFInfo
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- WO1999038545A1 WO1999038545A1 PCT/US1998/027731 US9827731W WO9938545A1 WO 1999038545 A1 WO1999038545 A1 WO 1999038545A1 US 9827731 W US9827731 W US 9827731W WO 9938545 A1 WO9938545 A1 WO 9938545A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/044—Proteins; Polypeptides; Degradation products thereof
- A61L29/048—Other specific proteins or polypeptides not covered by A61L29/045 - A61L29/047
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
Definitions
- This invention relates to the field of lubricious hydrophilic coatings for intracorporeal medical devices, and more particularly to a lubricious hydrophilic coating grafted onto a catheter or onto a guidewire.
- a medical devices within a patient may be facilitated by the presence of a lubricious surface on the device.
- intravascular devices such as catheters and guidewires
- the friction may be reduced by coating the device with a hydrophilic compound which becomes slippery after adsorbing an appreciable amount of water. Consequently, the hydrophilic coating provides lubricity when the coated device is exposed to aqueous solution, as when the coated device is exposed to water prior to insertion in the patient or to the patient's blood during use.
- coatings such as fluoropolymers, and silicone, provide lubricity to the surface of an intracorporeal device without the need for exposure to aqueous solution.
- degree of lubricity may vary greatly depending on the nature of the lubricious coating.
- Hydrophilic coatings provide superior lubricity compared to hydrophobic coatings, such as silicone, when tested against a biological tissue countersurface.
- an effective lubricious coating In addition to lowering the coefficient of friction of the coated device, an effective lubricious coating must strongly adhere to the device surface.
- the lubricious coating should remain adhered to the device surface during potentially extended periods of storage, as well as in response to abrasive forces encountered during use. Poor adhesive strength is undesirable because the lost coating may be left behind inside the patient during use, with a corresponding decrease in the lubricity of the device.
- a trade off exists between a coating's lubricity and the coating's adhesive and cohesive strength, so that attempts to increase the adhesive strength of lubricious coatings may inadvertently decrease the lubricity of 2
- the invention is directed to a method of providing a lubricious hydrophilic coating on an intracorporeal medical device, and the coated medical device produced thereby.
- a durable hydrophilic coating is provided on the medical device, which is highly lubricious when in contact with body fluids.
- the hydrophilic coating on the intracorporeal medical device generally includes a base coat and a lubricious hydrophilic top coat.
- the base coat has a binding component and a grafting component, and is used to strongly bind the hydrophilic top coat to the medical device.
- the binding component binds to both the hydrophilic polymer and to the grafting component, and the grafting component grafts to the device surface.
- the device is first coated with a solution which contains both the grafting component and the binding component. The coated device is then exposed to polymerizing radiation to polymerize the grafting component and form a base coat on the device.
- the device is then coated with a solution of the hydrophilic top coat, and the coated device allowed to dry, to form a hydrophilic coating on the device. Because the top coat bonds to the base coat during drying, the hydrophilic coating produced will not readily wear off, even after repeated hydration and abrasion.
- a base coat is not used, and the hydrophilic coating on the intracorporeal medical device generally includes a hydrophilic polymer, an ionic compound with at least one inorganic ion, and a grafting component.
- the grafting component is polymerized as outlined above, so that the grafting component grafts to the device and crosslinks to the hydrophilic polymer, to form a hydrophilic coating on the device. When the coated device is hydrated, the coating absorbs 3
- the hydrophilic coating increases the lubricity of the hydrophilic coating by providing uncrosslinked domains in the crosslinked matrix. Because the ability of a hydrophilic polymer to absorb water is decreased when the polymer is crosslinked, the salt enhances the polymer lubricity by disrupting the crosslinking of the hydrophilic polymer into the grafting component crosslinked network. Therefore, when the hydrophilic coating is hydrated by exposure to a solvent and the salt dissolves, these uncrosslinked domains provide additional lubricity by increasing the contact between the hydrophilic polymer and the countersurface, e.g. the patient's vessel wall, and hence additional lubricity.
- the coated device may be exposed to aqueous fluid either before insertion into a patient or by contact with body fluid while inside the patient.
- the hydrophilic coating of the invention can be applied to any device having a polymeric surface, as for example, a catheter formed of conventional materials.
- the catheter components may be formed of high density polyethylene, polyethylene terephthalate, and polyolephinic ionomers such as Surlyn®, nylon and the like which are frequently used to form dilatation balloons or catheter shafts.
- the device may be a metal device, such as a metal guidewire, that has been coated with a polymeric primer coating to produce a polymeric surface.
- the coated device of the invention has a superior hydrophilic coating which is highly lubricious against biological tissue and is strongly bound to the device surface due to the grafting component used alone or in combination with the binding - component.
- the coating serves to enhance device access to distal lesions and the ease with which a device crosses small diameter athlerosclerotic lesions.
- Fig. 1 is an elevational view, partially in section, of a dilatation catheter having a hydrophilic coating of the invention.
- Figs. 2 and 3 are transverse cross sections of the catheter shown in Fig. 1 taken along lines 2-2 and 3-3, respectively.
- Fig. 4 is an enlarged longitudinal cross-sectional view of the coated catheter shown in Fig. 1 within the circle 4.
- Fig. 5 is an elevational view, partially in section, of a dilatation catheter having a hydrophilic coating of the invention.
- Figs. 6 and 7 are transverse cross sections of the catheter shown in Fig. 5 taken along lines 6-6 and 7-7, respectively.
- Fig. 8 is a longitudinal cross section of a guidewire having a hydrophilic coating of the invention.
- Fig. 9 is a transverse cross section of the guidewire shown in Fig. 8 taken along lines 8-8.
- the intracorporeal medical device having a lubricious coating of the invention 10 is a dilatation catheter
- catheter shaft 11 generally including an elongated catheter shaft 12, with an inflatable dilatation balloon 13 on the distal end and an adapter mounted 16 on the proximal end.
- the catheter shaft 11 and balloon 13 are coated with a lubricious hydrophilic coating 18.
- the coating 18 comprises a base coat 19 and a top coat 20.
- Figs. 2 and 3 illustrate a transverse cross section of the catheter of Fig. 1 taken along lines 2-2 and 3-3, respectively.
- the catheter shaft may comprise an outer tubular member 21 , and an inner tubular member 22 disposed in a lumen of the outer tubular member and having a lumen configured to slidably receive a guidewire 23.
- the base coat has a grafting 5 component and a binding component.
- the grafting component is selected from the group consisting of vinyl compounds, acrylate compounds, and allyl compounds, such as any oligomer or monomer with one or more vinyl, acrylate or allyl double bonds.
- the vinyl compounds are di-vinyl benzene, n-vinyl pyrrolidone, and triethylene glycol divinyl ether.
- exemplary of the acrylate compounds are tri- methylol propane tri-acrylate, pentaerythritol tetra-acrylate, and Bisphenol A. ethoxylate diacrylate.
- Exemplary of the allyl compounds are allyl ether, di-allyl maleate, and tri-allyl isocyanurate.
- the grafting component is blended with a binding component, with the nature of the binding component varying depending on the identity of the hydrophilic top coat 20 that will be applied thereto.
- the binding component and hydrophilic compound have functional groups capable of binding to one another, so that the hydrophilic compound will be securely bound to the medical device through covalent attachment to the binding component.
- the binding component is selected from the group consisting of polyaziridine and polycarbodiimide resin compounds
- the top coat is a hydrophilic polymer having carboxyl groups capable of binding to the binding component.
- Exemplary of the polyaziridine compounds are tri-aziridine oligomer, such as Zeneca cs-100 available from Zeneca Resins.
- the hydrophilic compound is a polymer showing appreciable water absorption and containing carboxyl groups, including but not limited to, polyacrylic acid, alginic acid, carboxy methyl cellulose, and hyaluronic acid.
- the binding component comprises an aldehyde - compound and the top coat is a hydrophilic compound having amine groups.
- aldehyde compounds are glutaraldehyde, cinnamaldehyde, and acrolein.
- hydrophilic compound examples include a (co)monomer selected from the group consisting of 2-aminoethyl acrylate, 2-aminoethyl methacrylate, and N-(3- aminopropyl) methacrylamide; or a polymer of at least one of said (co)monomers co- polymerized with hydrophilic monomers selected from the group consisting of acrylamide, di-methyl acrylamide, and N-vinyl pyrrolidone; or a peptide having a secondary basic group for reaction with the aldehyde of the binding component, 6
- arginine such as arginine, glutamine, and histidine, which include but are not limited to gelatin, hirudin, and albumin; or polyethylenimine.
- the binding component is an isocyanate compound and the top coat is a compound showing appreciable water absorption and containing hydroxy or amine groups.
- isocyanate compounds are an aliphatic or aromatic isocyanate monomer, biuret or isocyanurate oligomer, or polyol or polyamine chain extended variant of such starting materials as 1 ,6 hexamethylene diisocyanate, isophorone diisocyanate, toluene diisocyanate, diphenylmethane-diisocyanate, bis(4-isocyanato cyclohexyl) methane.
- the isocyanate compound can also be the monomer or polymer made from allyl isocyanate or other such monomers.
- the hydrophilic compound are poly(vinyl alcohol), hydroxy propyl cellulose, hyaluronic acid, a peptide having a secondary basic group for reaction with the isocyanate of the binding component, and a copolymer blend of a first monomer selected from the group consisting of vinyl and acrylic monomers and a second monomer selected from the group consisting of hydroxy and amine monomers.
- Examples of the peptide include but are not limited to gelatin, hirudin, and albumin, and examples of the copolymer blend hydrophilic polymers include but are not limited to an 80/20 mixture of acrylamide and hydroxy ethyl methacrylate. In the embodiment illustrated in Figs.
- the method of providing a lubricious hydrophilic coating on an intracorporeal medical device of the invention comprises, applying to the medical device a solution having a binding component and a grafting component, and - polymerizing the grafting component so that the grafting component grafts to the device and crosslinks with the binding component, to form the base coat 19.
- the device thus coated with the base coat 19, hereafter the base coated device may typically be dried, either a room temperature or at elevated temperatures, to evaporate the base coat solution solvent, before polymerizing the grafting component.
- the base coat on the device is then coated with a solution of a hydrophilic compound to form the top coat 20.
- the coated device is then dried, at elevated or room temperature, so that the hydrophilic polymer grafts via covalent 7
- the coating 18 can then be hydrated by exposure to aqueous solution, rendering it highly lubricious.
- the hydrophilic coating may be exposed to a basic solution, such as
- Polymerization of the grafting component is carried out by irradiating the base coated device with ultra-violet (UV) light or with electron beam irradiation.
- UV light When UV light is used, photoinitiators must be present in the base coat solution.
- the UV light induces free radicals on the photoinitiators, which transfer to the acrylate, vinyl or allyl compound of the grafting component, thereby causing the grafting component to polymerize into a crosslinked network.
- UV light ultraviolet light
- electron beam irradiation are known in the art as radiation induced acrylate/vinyl free radical polymerization.
- the acrylate, vinyl or allyl network crosslinks to the functional groups of the binding component, e.g. the polyaziridine or polycarbodiimide oligomers, the isocyanate containing oligomer, or the aldehyde or polyaldehyde compound, and grafts to the device polymeric surface via a hydrogen abstraction mechanism.
- the binding component e.g. the polyaziridine or polycarbodiimide oligomers, the isocyanate containing oligomer, or the aldehyde or polyaldehyde compound
- the photoinitiator is any compound that generates a free radical when irradiated with UV or visible light.
- exemplary of the photoinitiator are benzophenone, * benzoin methyl ether, 2,2 dimethoxy-2-phenyiacetophenone, 1-hydroxycyclohexyl phenyl ketone, and ethyl 4-(dimethylamino)benzoate.
- Fig. 5 illustrates another embodiment of the invention, in which the binding component is omitted, and the coating 26 comprises a grafting component blended with the hydrophilic compound before being applied to the device.
- Figs. 6 and 7 illustrate transverse cross sections of the coated catheter shown in Fig. 5.
- the method of providing a lubricious hydrophilic coating on an intracorporeal medical device comprises applying to the device a solution 8
- the coated device comprising a hydrophilic polymer, an ionic compound with at least one inorganic ion, and a grafting component.
- the grafting component is polymerized so that the grafting component grafts to the device and crosslinks with the hydrophilic polymer, with some uncrosslinked domains remaining in the crosslinked matrix.
- the coated device is typically dried before exposure to the polymerizing radiation. The coated device can then be hydrated by exposure to an aqueous solution, whereby the hydrophilic polymer absorbs the solution and the salt dissolves, rendering the coating highly lubricious.
- the hydrophilic compound is any polymer displaying appreciable water absorption, including but not limited to poly(ethylene oxide), poly(vinylpyrrolidone), poly(vinyl alcohol), poly(acrylamide), alginic acid, hyaluronic acid, poly(acrylic acid), and guar gum.
- the grafting component and its polymerization are as discussed in the previous embodiments.
- Suitable ionic compounds with at least 1 inorganic ion, i.e. a salt include but are not limited to potassium bromide, and sodium chloride.
- a primer coating is applied to the device before applying the hydrophilic coating.
- Fig. 8 illustrates a metal guidewire 23 having a primer coat 28 and a lubricious hydrophilic coating 27 of the invention.
- the primer coat 28 is applied to at least the entire length of the guidewire to be coated with the hydrophilic coating.
- the polymerized primer coating 28 is selected from the group consisting of vinyl, acrylate and allyl compounds. The vinyl or acrylate compounds of the primer and the polymerization of these compounds are as discussed above for the grafting components.
- Fig. 9 illustrates a transverse cross section of the guidewire shown in Fig. 8 along lines 9-9. In the presently preferred embodiment illustrated in Fig.
- the hydrophilic coating 27 is the same as coating 26, comprising a grafting component blended directly with a hydrophilic compound and an ionic compound with at least one inorganic ion.
- the hydrophilic coating 27 may comprise the hydrophilic coating 18 having a base coat 19 and top coat 20 as discussed above.
- a solution comprising the primer coating is applied to the guidewire 23, and primer coat 28 is typically dried before the vinyl or acrylate compound is polymerized.
- grafting component is then applied to the primer coat and exposed to polymerizing radiation, to form the hydrophilic coating 27 on the guidewire.
- the presently preferred method of coating the device with the coating(s) is by dip coating at a given rate.
- the device may be coated by numerous suitable methods, including but not limited to, spray coating, wipe coating, or other techniques known in the art.
- Many suitable solvents may be used in the coating solutions including but not limited to water, alcohols, and ketones.
- the device is a polymeric catheter, or a metal guidewire coated with a primer.
- the device can be any intracorporeal medical device in which a reduction of friction or modification of the surface absorption properties is desired.
- the surface of the device is generally cleaned before coating with the primer or the hydrophilic coating solutions, and may optionally be plasma treated to improve coating adhesion.
- the lubricious hydrophilic coating 18, 26 on a dilatation catheter covers the outer surfaces of both the catheter shaft and balloon.
- the coating may be applied to various catheter surfaces, including an inner surface of the catheter to facilitate displacement of objects, such as a guidewire, within a lumen of the catheter, or an outer surface of the inner tubular member 22.
- the hydrophilic coating 18, 26, 27 may be applied to less than the entire outer surface of the device, as when a proximal portion of the catheter or guidewire is left uncoated to provide a handling location, or when the balloon is left uncoated to provide frictional engagement with the patient when the balloon is inflated.
- the coating 18, 26 would be applied to about -2 cm to about 105 cm of the catheter.
- the coating 27 would be applied to about 2 cm to about 40 cm of the total guidewire length of 175 cm.
- the percent values for the coating components is a percent by weight of the total formula weight. 10
- Base coat 1 Binding component: polyaziridine or 5-70% polycarbodiimide compound
- Grafting component vinyl or acrylic 10-95% functional monomer/oligomer
- Top coat 1. Hydrophilic compound: carboxyl 0.05-15% containing polymer
- Binding component isocyanate 5-90% functional monomer/oligomer/polymer
- Top coat 1 Hydrophilic compound hydroxy or 0 05-20% amine containing polymer
- Top coat 1. Hydrophilic compound amine 0 01-20% containing polymer
- a base coat comprising 0.5 grams (gm) tri-aziridine oligomer (Zeneca cx- 100), 1.5 gm trimethylol propane tri-acrylate, with an intermediate chain extension of 200 molecular weight (mol. wgt.) PEG (Henkel Photomer 4158), 0.004 gm benzophenone and 0.004 gm. 2,2 dimethoxy-2-phenylacetophenone, in 17.9 gm n- butyl acetate was applied to a coronary dilatation catheter that had been chemically cleaned and plasma treated by dip coating the catheter in a base coat solution at 20 inches per minute.
- the base coated device was dried for 20 seconds at 110°F, then irradiated in front of a Fusion Systems, "H" Bulb, ultra-violet source for 20 seconds at a minimum intensity of 50 milliwatts per square centimeter.
- the dried coated device was then dipped in 0.1 N KOH, and rinsed freely with water, to neutralize any free carboxyl groups on the hydrophilic polymer to increase the hydrophilic character of the topcoat and enhance its lubricity.
- the resulting catheter having a lubricious hydrophilic coating is extremely lubricious when wet, and the coating showed resistance to wearing off. If rubbed repeatedly under running water and then tested for lubricity against an excised porcine aorta counter surface, the catheter had a coefficient of friction of 0.08.
- a similar unit without the basecoat of the invention had a coefficient of friction of 0.32, which is equivalent to an uncoated catheter.
- Example 2 The procedure outlined above in Example 2 was performed using lubricious hydrophilic coatings from the class of coatings labeled "Formula II" and "Formula III” in Example 1 , except that the dried coated device is not dipped in a basic neutralizing solution.
- the base coat was applied to a coronary dilatation catheter that was chemically cleaned and plasma treated, by dip coating at 20 inches/min.
- the base coated catheter was then dried for 20 seconds at 110° F, and then irradiated in front of an ultra-violet source (Fusion Systems, "H” Bulb) for 20 13
- the top coat was then applied by dip coating at 20 in./min., and the coated catheter was baked in a convection oven at 55° C for 15 min.
- the resulting catheter having a lubricious hydrophilic coating is extremely lubricious when wet, and the coating showed resistance to wearing off.
- the base coat was 1.5 gm isocyanurate trimer of 1 ,6 hexamethylene diisocyanate (Bayer Desmodur N-3300), 0.5 gm trimethylol propane tri-acrylate, with an intermediate chain extension of 200 mol. wgt. PEG (Henkel Photomer 4158), 0.004 gm benzophenone, 0.004 gm 2,2 dimethoxy-2- phenylacetophenone, 0.0005 gm dibutyl tin dilaurate, and 17.9 gm n-butyl acetate, and the top coat was 2.0 gm poly(vinyl alcohol) (mol. wgt. 100K), and 98.0 gm water.
- the base coat was 2.0 gm of glutaraldehyde (25% in water), 1.5 gm trimethylol propane tri-acrylate, with an intermediate chain extension of 200 mol. wgt. PEG (Henkel Photomer 4158), 0.004 gm benzophenone, 0.004 gm 2,2 dimethoxy-2-phenylacetophenone, and 17.9 gm 2-propanol, and the top coat was 2.0 gm gelatin (175 bloom, swine skin, Aldrich Chemical Co.), and 98.0 gm water.
- Grafting component vinyl or acrylic functional 5-45% monomer/oligomer
- the coating was applied to a coronary dilatation catheter that was chemically cleaned and plasma treated, by dip coating at 20 in./min.
- the coated catheter was dried for 20 sec. at 110° F, and then UV irradiate as outlined above.
- the hydrophilic coating yields an average force of 31 gm, as opposed to 98 gm for a control silicone coating, for a 68% reduction in force.
- Primer coat 1 Vinyl or acrylate containing monomer or 90-100% oligomer
- Grafting component vinyl or acrylic 5-49% coating blend functional monomer/oligomer
- the mixture was stirred until poly(ethylene oxide) was fully dissolved, about 1 hour.
- the top coat was applied to the primed guidewire by dipping, drying, and then irradiating as outlined for the primer coat.
- the guidewire thus coated has a durable lubricious coating when wet, resulting in a coefficient of friction of 0.03, compared to a coefficient of friction of 0.18 for a silicone coating.
- the hydrophilic coating was found to slough off rapidly when wet if the primer coat was omitted.
Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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AU20192/99A AU2019299A (en) | 1998-01-30 | 1998-12-31 | Lubricious hydrophilic coating for an intracorporeal medical device |
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US09/016,694 US6221425B1 (en) | 1998-01-30 | 1998-01-30 | Lubricious hydrophilic coating for an intracorporeal medical device |
US09/016,694 | 1998-01-30 |
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WO1999038545A1 true WO1999038545A1 (en) | 1999-08-05 |
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PCT/US1998/027731 WO1999038545A1 (en) | 1998-01-30 | 1998-12-31 | Lubricious hydrophilic coating for an intracorporeal medical device |
PCT/US1999/001919 WO1999038546A1 (en) | 1998-01-30 | 1999-01-29 | Hydrophilic coating for an intracorporeal medical device |
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US (3) | US6221425B1 (en) |
EP (1) | EP1051208B1 (en) |
JP (1) | JP2002501788A (en) |
AT (1) | ATE330646T1 (en) |
AU (2) | AU2019299A (en) |
CA (1) | CA2316223A1 (en) |
DE (1) | DE69932034T2 (en) |
WO (2) | WO1999038545A1 (en) |
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EP2103318A1 (en) | 2008-03-20 | 2009-09-23 | Bayer MaterialScience AG | Medical devices with hydrophilic coatings |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US7282220B1 (en) * | 1996-11-05 | 2007-10-16 | Hsing-Wen Sung | Genipin-crosslinked gelatin microspheres as drug carrier |
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US20040043068A1 (en) * | 1998-09-29 | 2004-03-04 | Eugene Tedeschi | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
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US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6358557B1 (en) * | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
EP1104681A1 (en) * | 1999-12-03 | 2001-06-06 | Biomat B.V. | Wire, tube or catheter with hydrophilic coating |
AU2001228653A1 (en) * | 2000-01-24 | 2001-07-31 | Biocompatibles Limited | Coated implants |
SE0000363L (en) * | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Coated medical device |
AU4907901A (en) * | 2000-02-28 | 2001-11-26 | Gel Del Technologies Inc | Protein matrix materials, devices and methods of making and using thereof |
US7220276B1 (en) * | 2000-03-06 | 2007-05-22 | Surmodics, Inc. | Endovascular graft coatings |
AU2001247425A1 (en) | 2000-04-10 | 2001-10-23 | Advanced Cardiovascular Systems Inc. | Selectively coated stent delivery system and method of manufacture thereof |
US7682648B1 (en) | 2000-05-31 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for forming polymeric coatings on stents |
US6673385B1 (en) | 2000-05-31 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Methods for polymeric coatings stents |
US6695817B1 (en) | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
US6451003B1 (en) * | 2000-08-16 | 2002-09-17 | Biolink Corporation | Method and apparatus for overcoming infection in a tissue pocket surrounding an implanted device |
US6706274B2 (en) * | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
US8840927B2 (en) * | 2001-02-28 | 2014-09-23 | Covalon Technologies Inc. | Method of making anti-microbial polymeric surfaces |
US20020163504A1 (en) * | 2001-03-13 | 2002-11-07 | Pallakoff Matthew G. | Hand-held device that supports fast text typing |
DE10115740A1 (en) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Preparation for restenosis prophylaxis |
US20020161376A1 (en) * | 2001-04-27 | 2002-10-31 | Barry James J. | Method and system for delivery of coated implants |
US6673453B2 (en) * | 2001-06-12 | 2004-01-06 | Biocoat Incorporated | Coatings appropriate for medical devices |
US6702744B2 (en) | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
SE523216C2 (en) * | 2001-07-27 | 2004-04-06 | Zoucas Kirurgkonsult Ab | heparin stent |
US7682669B1 (en) * | 2001-07-30 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device |
CA2455923A1 (en) * | 2001-07-30 | 2003-10-09 | Sts Biopolymers, Inc. | Graft polymer matrices |
US7135189B2 (en) * | 2001-08-23 | 2006-11-14 | Boston Scientific Scimed, Inc. | Compositions and techniques for localized therapy |
US20030060873A1 (en) * | 2001-09-19 | 2003-03-27 | Nanomedical Technologies, Inc. | Metallic structures incorporating bioactive materials and methods for creating the same |
US7776379B2 (en) * | 2001-09-19 | 2010-08-17 | Medlogics Device Corporation | Metallic structures incorporating bioactive materials and methods for creating the same |
JP2005504813A (en) * | 2001-09-24 | 2005-02-17 | メドトロニック・エイヴイイー・インコーポレーテッド | Rational drug therapy device and method |
MXPA04003162A (en) * | 2001-10-05 | 2005-01-25 | Surmodics Inc | Particle immobilized coatings and uses thereof. |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US20040143180A1 (en) * | 2001-11-27 | 2004-07-22 | Sheng-Ping Zhong | Medical devices visible under magnetic resonance imaging |
US8608661B1 (en) | 2001-11-30 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Method for intravascular delivery of a treatment agent beyond a blood vessel wall |
US20030109865A1 (en) * | 2001-12-12 | 2003-06-12 | Megadyne Medical Products, Inc. | Utilization of a multi-character material in a surface coating of an electrosurgical instrument |
FR2833961B1 (en) * | 2001-12-20 | 2004-04-02 | Virsol | PROCESS FOR THE PREPARATION OF CROSSLINKED POLY (ETHYLENE OXIDE) FILMS |
US7357949B2 (en) * | 2001-12-21 | 2008-04-15 | Agion Technologies Inc. | Encapsulated inorganic antimicrobial additive for controlled release |
US7348055B2 (en) * | 2001-12-21 | 2008-03-25 | Surmodics, Inc. | Reagent and method for providing coatings on surfaces |
US20030118658A1 (en) * | 2001-12-21 | 2003-06-26 | Trogolo Jeffrey A. | High aspect ratio encapsulated inorganic antimicrobial additive for controlled release |
US20050008839A1 (en) * | 2002-01-30 | 2005-01-13 | Cramer Ronald Dean | Method for hydrophilizing materials using hydrophilic polymeric materials with discrete charges |
US8728510B1 (en) * | 2002-03-15 | 2014-05-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing a bioadhesive material |
US7387836B2 (en) * | 2002-04-17 | 2008-06-17 | Genzyme Corporation | Aziridine compounds and their use in medical devices |
US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
US7519418B2 (en) * | 2002-04-30 | 2009-04-14 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
US7097850B2 (en) * | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US8506617B1 (en) | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
US7361368B2 (en) | 2002-06-28 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Device and method for combining a treatment agent and a gel |
AU2003256540B2 (en) * | 2002-07-12 | 2008-12-11 | Cook Medical Technologies Llc | Coated medical device |
US9955994B2 (en) | 2002-08-02 | 2018-05-01 | Flowcardia, Inc. | Ultrasound catheter having protective feature against breakage |
US8133236B2 (en) | 2006-11-07 | 2012-03-13 | Flowcardia, Inc. | Ultrasound catheter having protective feature against breakage |
US7137963B2 (en) | 2002-08-26 | 2006-11-21 | Flowcardia, Inc. | Ultrasound catheter for disrupting blood vessel obstructions |
US6942677B2 (en) | 2003-02-26 | 2005-09-13 | Flowcardia, Inc. | Ultrasound catheter apparatus |
US7335180B2 (en) | 2003-11-24 | 2008-02-26 | Flowcardia, Inc. | Steerable ultrasound catheter |
US7220233B2 (en) | 2003-04-08 | 2007-05-22 | Flowcardia, Inc. | Ultrasound catheter devices and methods |
US7604608B2 (en) | 2003-01-14 | 2009-10-20 | Flowcardia, Inc. | Ultrasound catheter and methods for making and using same |
US20030039697A1 (en) * | 2002-09-12 | 2003-02-27 | Yi-Ju Zhao | Matrices containing nitric oxide donors and reducing agents and their use |
DE10244847A1 (en) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medical device for drug delivery |
US20040057983A1 (en) | 2002-09-25 | 2004-03-25 | David Schmidt | Biomolecular wearable apparatus |
US20060100695A1 (en) * | 2002-09-27 | 2006-05-11 | Peacock James C Iii | Implantable stent with modified ends |
US6770729B2 (en) * | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
US20040148016A1 (en) * | 2002-11-07 | 2004-07-29 | Klein Dean A. | Biocompatible medical device coatings |
EP2336318B1 (en) | 2002-11-13 | 2013-04-24 | Genzyme Corporation | Antisense modulation of apolipoprotein b expression |
ES2417879T3 (en) | 2002-11-13 | 2013-08-09 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
US7776926B1 (en) | 2002-12-11 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for implantable medical devices |
US7758880B2 (en) | 2002-12-11 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible polyacrylate compositions for medical applications |
US7220491B2 (en) * | 2002-12-19 | 2007-05-22 | Kimberly-Clark Worldwide, Inc. | Lubricious coating for medical devices |
US7264859B2 (en) * | 2002-12-19 | 2007-09-04 | Kimberly-Clark Worldwide, Inc. | Lubricious coating for medical devices |
US7628859B1 (en) * | 2002-12-27 | 2009-12-08 | Advanced Cardiovascular Systems, Inc. | Mounting assembly for a stent and a method of using the same to coat a stent |
US20040236415A1 (en) * | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
US20060047261A1 (en) * | 2004-06-28 | 2006-03-02 | Shailendra Joshi | Intra-arterial catheter for drug delivery |
US20060135940A1 (en) * | 2003-01-06 | 2006-06-22 | The Trustees Of Columbia | Programmed pulsed infusion methods and devices |
US6742952B1 (en) | 2003-02-28 | 2004-06-01 | Bic Corporation | Transparent or translucent tubular structure |
AU2004216404C1 (en) | 2003-02-28 | 2011-04-28 | Biointeractions Ltd. | Polymeric network system for medical devices and methods of use |
JP4614630B2 (en) * | 2003-03-31 | 2011-01-19 | 有限会社筑波物質情報研究所 | Functional polymer compound and biosensor using the same |
WO2005089380A2 (en) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids |
US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
EP1608319A4 (en) * | 2003-04-03 | 2007-02-28 | Univ California | Improved inhibitors for the soluble epoxide hydrolase |
US20050164951A1 (en) * | 2003-04-03 | 2005-07-28 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
US8821473B2 (en) | 2003-04-15 | 2014-09-02 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US8038991B1 (en) | 2003-04-15 | 2011-10-18 | Abbott Cardiovascular Systems Inc. | High-viscosity hyaluronic acid compositions to treat myocardial conditions |
US20040215313A1 (en) * | 2003-04-22 | 2004-10-28 | Peiwen Cheng | Stent with sandwich type coating |
JP4824549B2 (en) | 2003-05-02 | 2011-11-30 | サーモディクス,インコーポレイティド | Controlled release bioactive substance delivery device |
US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
US6923996B2 (en) * | 2003-05-06 | 2005-08-02 | Scimed Life Systems, Inc. | Processes for producing polymer coatings for release of therapeutic agent |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US8465537B2 (en) | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7318945B2 (en) * | 2003-07-09 | 2008-01-15 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent having dipped layers |
US20050124896A1 (en) * | 2003-08-25 | 2005-06-09 | Jacob Richter | Method for protecting implantable sensors and protected implantable sensors |
DE60312326T2 (en) * | 2003-09-03 | 2007-11-08 | Research In Motion Ltd., Waterloo | Methods and apparatus for displaying a home network name |
US20050113687A1 (en) * | 2003-09-15 | 2005-05-26 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using a porous medical device |
US8021331B2 (en) * | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
EP1663343B8 (en) * | 2003-09-15 | 2019-12-04 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US7758510B2 (en) | 2003-09-19 | 2010-07-20 | Flowcardia, Inc. | Connector for securing ultrasound catheter to transducer |
US7953499B2 (en) * | 2003-09-30 | 2011-05-31 | Cardiac Pacemakers, Inc. | Drug-eluting electrode |
EP1675908B1 (en) * | 2003-10-07 | 2008-12-17 | Coloplast A/S | Composition useful as an adhesive ans use of such a composition |
US7208172B2 (en) * | 2003-11-03 | 2007-04-24 | Medlogics Device Corporation | Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices |
BR0318575A (en) * | 2003-11-07 | 2006-10-10 | Bayco Tech Ltd | method for preparing medical device for drug elution and device obtained therefrom |
US9114198B2 (en) | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
CA2536242A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
WO2005052366A2 (en) * | 2003-11-20 | 2005-06-09 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Portable hand pump for evacuation of fluids |
US20060085062A1 (en) * | 2003-11-28 | 2006-04-20 | Medlogics Device Corporation | Implantable stent with endothelialization factor |
US20050119723A1 (en) * | 2003-11-28 | 2005-06-02 | Medlogics Device Corporation | Medical device with porous surface containing bioerodable bioactive composites and related methods |
US20050154455A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050149174A1 (en) * | 2003-12-18 | 2005-07-07 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154451A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152943A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
AU2004308492A1 (en) * | 2003-12-23 | 2005-07-14 | Abbott Medical Optics Inc. | Lubricious, biocompatible coatings for medical devices |
US20050152942A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154452A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152940A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7959659B2 (en) * | 2004-01-02 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | High-density lipoprotein coated medical devices |
US20050159809A1 (en) * | 2004-01-21 | 2005-07-21 | Medtronic Vascular, Inc. | Implantable medical devices for treating or preventing restenosis |
US20050165452A1 (en) * | 2004-01-28 | 2005-07-28 | Medtronic, Inc. | Antithrombogenic medical device |
US7534495B2 (en) * | 2004-01-29 | 2009-05-19 | Boston Scientific Scimed, Inc. | Lubricious composition |
US20050197691A1 (en) * | 2004-02-18 | 2005-09-08 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8137397B2 (en) * | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
WO2005097673A1 (en) * | 2004-03-30 | 2005-10-20 | Toyo Advanced Technologies Co., Ltd. | Method for treating surface of base, surface-treated base, material for medical use and instrument for medical use |
US8043631B2 (en) * | 2004-04-02 | 2011-10-25 | Au Jessie L S | Tumor targeting drug-loaded particles |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US8211115B2 (en) * | 2004-05-06 | 2012-07-03 | Boston Scientific Scimed, Inc. | Variable size retrieval basket |
US7758572B2 (en) * | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices and methods including cooling balloons having nanotubes |
US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
US7563780B1 (en) | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US7595355B2 (en) | 2004-06-24 | 2009-09-29 | Agion Technologies, Inc. | Antimicrobial coating for erosive environments |
US7494665B1 (en) | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
US7540852B2 (en) | 2004-08-26 | 2009-06-02 | Flowcardia, Inc. | Ultrasound catheter devices and methods |
US20060062822A1 (en) * | 2004-09-21 | 2006-03-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7776380B2 (en) * | 2004-09-22 | 2010-08-17 | Volcano Corporation | Method of making catheters with additives consolidated into polymer wall |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
WO2006036964A2 (en) | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Barrier layer |
US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US8337475B2 (en) | 2004-10-12 | 2012-12-25 | C. R. Bard, Inc. | Corporeal drainage system |
US20060083770A1 (en) * | 2004-10-15 | 2006-04-20 | Specialty Coating Systems, Inc. | Medical devices and methods of preparation and use |
WO2006045119A2 (en) * | 2004-10-20 | 2006-04-27 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
US20060088571A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic Vascular, Inc. | Biocompatible and hemocompatible polymer compositions |
US8603634B2 (en) | 2004-10-27 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | End-capped poly(ester amide) copolymers |
CA2586115C (en) | 2004-11-05 | 2013-04-23 | Icu Medical, Inc. | Medical connector for having high flow rate characteristics |
AU2005308920B2 (en) | 2004-11-29 | 2010-04-15 | Dsm Ip Assets B.V. | Method for reducing the amount of migrateables of polymer coatings |
US8874204B2 (en) | 2004-12-20 | 2014-10-28 | Cardiac Pacemakers, Inc. | Implantable medical devices comprising isolated extracellular matrix |
US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US7604818B2 (en) | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US8221343B2 (en) | 2005-01-20 | 2012-07-17 | Flowcardia, Inc. | Vibrational catheter devices and methods for making same |
WO2006091675A2 (en) * | 2005-02-23 | 2006-08-31 | Surmodics, Inc. | Implantable medical articles having laminin coatings and methods of use |
US7527604B2 (en) * | 2005-03-09 | 2009-05-05 | Boston Scientific Scimed, Inc. | Rotatable multi-port therapeutic delivery device |
US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
US8187621B2 (en) | 2005-04-19 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Methods and compositions for treating post-myocardial infarction damage |
US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
US8303972B2 (en) | 2005-04-19 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
DE602006011460D1 (en) * | 2005-06-02 | 2010-02-11 | Surmodics Inc | HYDROPHILIC POLYMER COATINGS FOR MEDICAL TECHNICAL DEVICES |
US20060282114A1 (en) * | 2005-06-09 | 2006-12-14 | Medtronic Vascular, Inc. | Embolic protection apparatus with vasodilator coating |
DE102005033520B4 (en) * | 2005-07-14 | 2007-12-20 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Preparation, in particular cosmetic preparation, process for their preparation and their use |
US8298565B2 (en) | 2005-07-15 | 2012-10-30 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
EP1904118B1 (en) * | 2005-07-20 | 2018-01-17 | Surmodics, Inc. | Polymeric coatings and methods for cell attachment |
US20070027530A1 (en) * | 2005-07-26 | 2007-02-01 | Medtronic Vascular, Inc. | Intraluminal device, catheter assembly, and method of use thereof |
BRPI0503201B8 (en) * | 2005-07-28 | 2021-05-25 | Sci Tech Produtos Medicos Ltda | stents coated with hydrophilic polymer blends, eluting nitric oxide and s-nitrosothiols |
US9101949B2 (en) | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US7896539B2 (en) | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
US20090220564A1 (en) * | 2005-08-19 | 2009-09-03 | Baumbach William R | Methods of treating and preventing acute myocardial infarction |
US20070048249A1 (en) | 2005-08-24 | 2007-03-01 | Purdue Research Foundation | Hydrophilized bactericidal polymers |
US8343473B2 (en) | 2005-08-24 | 2013-01-01 | Purdue Research Foundation | Hydrophilized antimicrobial polymers |
US20070067020A1 (en) * | 2005-09-22 | 2007-03-22 | Medtronic Vasular, Inc. | Intraluminal stent, delivery system, and a method of treating a vascular condition |
US8177772B2 (en) | 2005-09-26 | 2012-05-15 | C. R. Bard, Inc. | Catheter connection systems |
US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
WO2007065721A2 (en) * | 2005-12-09 | 2007-06-14 | Dsm Ip Assets B.V. | Hydrophilic coating comprising a polyelectrolyte |
US20070148390A1 (en) * | 2005-12-27 | 2007-06-28 | Specialty Coating Systems, Inc. | Fluorinated coatings |
US8053030B2 (en) | 2006-02-01 | 2011-11-08 | Hollister Incorporated | Methods of applying a hydrophilic coating to a substrate, and substrates having a hydrophilic coating |
TW200808723A (en) | 2006-03-13 | 2008-02-16 | Univ California | Conformationally restricted urea inhibitors of soluble epoxide hydrolase |
US20070231361A1 (en) * | 2006-03-28 | 2007-10-04 | Medtronic Vascular, Inc. | Use of Fatty Acids to Inhibit the Growth of Aneurysms |
US9282984B2 (en) | 2006-04-05 | 2016-03-15 | Flowcardia, Inc. | Therapeutic ultrasound system |
US9561351B2 (en) | 2006-05-31 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Drug delivery spiral coil construct |
US9028859B2 (en) | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
US7732190B2 (en) | 2006-07-31 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
US20080057298A1 (en) * | 2006-08-29 | 2008-03-06 | Surmodics, Inc. | Low friction particulate coatings |
US20100076546A1 (en) * | 2006-09-13 | 2010-03-25 | Dsm Ip Assets B.V. | Coating formulation for medical coating |
WO2008031601A1 (en) * | 2006-09-13 | 2008-03-20 | Dsm Ip Assets B.V. | Antimicrobial hydrophilic coating comprising metallic silver particles |
JP5015258B2 (en) | 2006-10-25 | 2012-08-29 | アイシーユー・メディカル・インコーポレーテッド | Medical connector |
US8246643B2 (en) | 2006-11-07 | 2012-08-21 | Flowcardia, Inc. | Ultrasound catheter having improved distal end |
US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
US8741326B2 (en) | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8192760B2 (en) | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
US20080140022A1 (en) * | 2006-12-08 | 2008-06-12 | Warsaw Orthopedic, Inc. | Coated Cannula with Protective Tip for Insertion Into a Patient |
US20080181928A1 (en) * | 2006-12-22 | 2008-07-31 | Miv Therapeutics, Inc. | Coatings for implantable medical devices for liposome delivery |
US8273402B2 (en) * | 2007-02-26 | 2012-09-25 | Medtronic Vascular, Inc. | Drug coated stent with magnesium topcoat |
MX339467B (en) * | 2007-02-28 | 2016-05-27 | Dsm Ip Assets Bv | Hydrophilic coating. |
CN101622019B (en) * | 2007-02-28 | 2015-01-07 | 帝斯曼知识产权资产管理有限公司 | Hydrophilic coating |
US20080294237A1 (en) * | 2007-04-04 | 2008-11-27 | Jack Fa-De Chu | Inflatable devices and methods to protect aneurysmal wall |
US9056155B1 (en) | 2007-05-29 | 2015-06-16 | Abbott Cardiovascular Systems Inc. | Coatings having an elastic primer layer |
US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
US8617114B2 (en) * | 2007-07-13 | 2013-12-31 | Abbott Cardiovascular Systems Inc. | Drug coated balloon catheter |
US7780095B2 (en) | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US7753285B2 (en) | 2007-07-13 | 2010-07-13 | Bacoustics, Llc | Echoing ultrasound atomization and/or mixing system |
US8690823B2 (en) * | 2007-07-13 | 2014-04-08 | Abbott Cardiovascular Systems Inc. | Drug coated balloon catheter |
US8128599B2 (en) | 2007-07-20 | 2012-03-06 | Tyco Healthcare Group Lp | Lubricious coatings |
EP2187746A4 (en) | 2007-08-06 | 2011-01-19 | Univ California | Preparation of novel 1,3-substituted ureas as inhibitors of soluble epoxide hydrolase |
US20090041923A1 (en) | 2007-08-06 | 2009-02-12 | Abbott Cardiovascular Systems Inc. | Medical device having a lubricious coating with a hydrophilic compound in an interlocking network |
CA2599082A1 (en) * | 2007-08-27 | 2009-02-27 | Ping I. Lee | Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds |
US8445217B2 (en) | 2007-09-20 | 2013-05-21 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
US8608049B2 (en) | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
US8216629B2 (en) * | 2007-10-29 | 2012-07-10 | Advanced Vision Science, Inc. | Lubricious intraocular lens insertion device |
KR20100122073A (en) | 2007-10-30 | 2010-11-19 | 유티아이 리미티드 파트너쉽 | Method and system for sustained-release of sclerosing agent |
US8512731B2 (en) * | 2007-11-13 | 2013-08-20 | Medtronic Minimed, Inc. | Antimicrobial coatings for medical devices and methods for making and using them |
DE102007055692A1 (en) * | 2007-12-03 | 2009-06-04 | Wacker Chemie Ag | Radically crosslinkable polymer compositions containing epoxy-functional copolymers |
WO2009076372A2 (en) | 2007-12-10 | 2009-06-18 | Molecular Sensing, Inc. | Temperature-stable interferometer |
US20090157047A1 (en) * | 2007-12-13 | 2009-06-18 | Boston Scientific Scimed, Inc. | Medical device coatings and methods of forming such coatings |
CA2711001A1 (en) | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein-based particles and methods thereof |
US8378011B2 (en) * | 2007-12-27 | 2013-02-19 | Boston Scientific Scimed, Inc. | Enhanced durability of hydrophilic coatings |
MX2010009982A (en) * | 2008-03-12 | 2010-09-30 | Dsm Ip Assets Bv | Hydrophilic coating. |
HUE044502T2 (en) * | 2008-04-17 | 2019-10-28 | Dentsply Ih Ab | Improved medical device with hydrophilic coating |
US9126025B2 (en) * | 2008-05-01 | 2015-09-08 | Bayer Intellectual Property Gmbh | Method of coating a folded catheter balloon |
US8602961B2 (en) * | 2008-05-15 | 2013-12-10 | Lifewave Products Llc | Apparatus and method of stimulating elevation of glutathione levels in a subject |
DE102008025614A1 (en) * | 2008-05-28 | 2009-12-03 | Bayer Materialscience Ag | Hydrophilic polyurethane coatings |
WO2009151624A1 (en) * | 2008-06-13 | 2009-12-17 | Xy, Inc. | Lubricious microfluidic flow path system |
CH699079A1 (en) * | 2008-07-04 | 2010-01-15 | Arik Zucker | Arrangement consisting of a stent and a package. |
US20100048758A1 (en) * | 2008-08-22 | 2010-02-25 | Boston Scientific Scimed, Inc. | Lubricious coating composition for devices |
US20100099203A1 (en) * | 2008-10-03 | 2010-04-22 | Molecular Sensing, Inc. | Substrates with surfaces modified with PEG |
DE102008054482A1 (en) | 2008-12-10 | 2010-06-17 | Wacker Chemie Ag | Graft copolymers and their use as low-profile additives |
WO2010080710A2 (en) * | 2009-01-12 | 2010-07-15 | Molecular Sensing, Inc. | Sample collection and measurement in a single container by back scattering interferometry |
US20100188665A1 (en) * | 2009-01-12 | 2010-07-29 | Molecular Sensing, Inc. | Methods and systems for interferometric analysis |
US20100209475A1 (en) * | 2009-02-19 | 2010-08-19 | Biomet Manufacturing Corp. | Medical implants having a drug delivery coating |
US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
JP5532665B2 (en) * | 2009-04-20 | 2014-06-25 | 株式会社カネカ | Stent delivery system |
US20100268191A1 (en) * | 2009-04-21 | 2010-10-21 | Medtronic Vascular, Inc. | Drug Delivery Catheter using Frangible Microcapsules and Delivery Method |
EP2427778A4 (en) | 2009-05-04 | 2013-02-13 | Molecular Sensing Inc | Analysis of membrane component interactions |
US8226566B2 (en) | 2009-06-12 | 2012-07-24 | Flowcardia, Inc. | Device and method for vascular re-entry |
US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
US20120232640A1 (en) * | 2009-11-19 | 2012-09-13 | Blue Medical Devices Bv | Narrow profile composition-releasing expandable medical balloon catheter |
US8287890B2 (en) * | 2009-12-15 | 2012-10-16 | C.R. Bard, Inc. | Hydrophilic coating |
EP2528604B1 (en) | 2010-01-29 | 2017-11-22 | The Regents of the University of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
WO2011097103A1 (en) * | 2010-02-02 | 2011-08-11 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
EP2566560A4 (en) * | 2010-05-07 | 2017-08-16 | Care Fusion 2200, Inc. | Catheter allowing variable dosing of an active agent |
US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
WO2011156713A1 (en) | 2010-06-11 | 2011-12-15 | Vanderbilt University | Multiplexed interferometric detection system and method |
MY161087A (en) | 2010-06-16 | 2017-04-14 | Dsm Ip Assets Bv | Coating formulation for preparing a hydrophilic coating |
US10322213B2 (en) | 2010-07-16 | 2019-06-18 | Atrium Medical Corporation | Compositions and methods for altering the rate of hydrolysis of cured oil-based materials |
US8541498B2 (en) | 2010-09-08 | 2013-09-24 | Biointeractions Ltd. | Lubricious coatings for medical devices |
US9327101B2 (en) | 2010-09-17 | 2016-05-03 | Abbott Cardiovascular Systems Inc. | Length and diameter adjustable balloon catheter |
CN103298517A (en) | 2010-09-17 | 2013-09-11 | 雅培心血管系统有限公司 | Length and diameter adjustable balloon catheter |
US9029401B2 (en) | 2011-02-14 | 2015-05-12 | The Regents Of The University Of California | Sorafenib derivatives as sEH inhibitors |
US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
US8931637B2 (en) * | 2011-05-04 | 2015-01-13 | Cook Medical Technologies Llc | Medical lumen access device assembly including medical lumen access device holder and method of use |
US20130085451A1 (en) * | 2011-09-29 | 2013-04-04 | Tyco Healthcare Group Lp | Plasma-treated dialysis catheter cuff |
WO2013109930A1 (en) | 2012-01-18 | 2013-07-25 | Surmodics, Inc. | Lubricious medical device coating with low particulates |
WO2013109269A1 (en) | 2012-01-18 | 2013-07-25 | Bard Peripheral Vascular, Inc. | Vascular re-entry device |
US9034903B2 (en) | 2012-02-01 | 2015-05-19 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
US8545951B2 (en) | 2012-02-29 | 2013-10-01 | Kimberly-Clark Worldwide, Inc. | Endotracheal tubes and other polymer substrates including an anti-fouling treatment |
RU2482883C1 (en) * | 2012-03-12 | 2013-05-27 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Method for preparing fibre polymeric composites with antimicrobial activity |
US9849005B2 (en) * | 2012-04-16 | 2017-12-26 | Biotronik Ag | Implant and method for manufacturing same |
US20130304180A1 (en) | 2012-05-09 | 2013-11-14 | Michael L. Green | Catheter having dual balloon hydraulic actuator |
US9011513B2 (en) | 2012-05-09 | 2015-04-21 | Abbott Cardiovascular Systems Inc. | Catheter having hydraulic actuator |
US9271855B2 (en) | 2012-05-09 | 2016-03-01 | Abbott Cardiovascular Systems Inc. | Catheter having hydraulic actuator with tandem chambers |
US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
CA2874824C (en) | 2012-06-01 | 2021-10-26 | Surmodics, Inc. | Apparatus and methods for coating balloon catheters |
US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
US8684963B2 (en) | 2012-07-05 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Catheter with a dual lumen monolithic shaft |
EP3895632A1 (en) | 2012-08-02 | 2021-10-20 | Bard Peripheral Vascular, Inc. | Ultrasound catheter system |
US20140220331A1 (en) | 2013-02-02 | 2014-08-07 | Cosilion LLC | Antimicrobial compositions |
US9283101B2 (en) | 2013-03-12 | 2016-03-15 | Abbott Cardiovascular Systems Inc. | Catheter having hydraulic actuator and locking system |
US9326875B2 (en) | 2013-03-13 | 2016-05-03 | Abbott Cardiovascular Systems Inc. | Catheter having a movable tubular structure and method of making |
WO2014142808A1 (en) | 2013-03-12 | 2014-09-18 | Abbott Cardiovascular Systems Inc. | Catheter having hydraulic actuator and locking system |
US9623216B2 (en) | 2013-03-12 | 2017-04-18 | Abbott Cardiovascular Systems Inc. | Length and diameter adjustable balloon catheter for drug delivery |
US10420662B2 (en) | 2013-03-12 | 2019-09-24 | Abbott Cardiovascular Systems Inc. | Catheter having movable tubular structure and proximal stopper |
US10531971B2 (en) | 2013-03-12 | 2020-01-14 | Abbott Cardiovascular System Inc. | Balloon catheter having hydraulic actuator |
JP6615743B2 (en) | 2013-03-12 | 2019-12-04 | アボット カーディオバスキュラー システムズ インコーポレイテッド | Catheter with movable tubular structure and proximal stopper |
EP2914325A1 (en) | 2013-03-14 | 2015-09-09 | Abbott Cardiovascular Systems Inc. | Stiffness adjustable catheter |
WO2014151283A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Cardiovascular Systems Inc. | Length adjustable balloon catheter for multiple indications |
CN103212112B (en) * | 2013-05-06 | 2015-10-07 | 中国热带农业科学院南亚热带作物研究所 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
EP2996629B1 (en) | 2013-05-15 | 2021-09-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
EP2949782B1 (en) * | 2013-10-18 | 2019-12-11 | Sumitomo Rubber Industries, Ltd. | Surface-modified metal and method for modifying metal surface |
WO2015065491A1 (en) | 2013-11-04 | 2015-05-07 | Abbot Cardiovascular Systems Inc. | Length adjustable balloon catheter |
EP3079739B1 (en) | 2013-12-11 | 2023-02-22 | ICU Medical, Inc. | Check valve |
KR102462510B1 (en) * | 2014-08-26 | 2022-11-01 | 씨. 알. 바드, 인크. | Urinary catheter |
WO2016033424A1 (en) | 2014-08-29 | 2016-03-03 | Genzyme Corporation | Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b |
US10124088B2 (en) | 2014-09-29 | 2018-11-13 | Surmodics, Inc. | Lubricious medical device elements |
USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
JP6154370B2 (en) | 2014-12-26 | 2017-06-28 | 住友ゴム工業株式会社 | Surface-modified metal and method for modifying metal surface |
JP2018506715A (en) | 2015-01-23 | 2018-03-08 | ヴァンダービルト ユニバーシティー | Robust interferometer and method of use |
CA2982591A1 (en) | 2015-04-16 | 2016-10-20 | Hollister Incorporated | Hydrophilic coatings and methods of forming the same |
JP6670325B2 (en) * | 2015-05-08 | 2020-03-18 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Hydrophilic coating for intra-conduit devices |
JP6249987B2 (en) * | 2015-05-13 | 2017-12-20 | ルトニックス,インコーポレーテッド | Drug release coating for medical devices |
GB201509919D0 (en) * | 2015-06-08 | 2015-07-22 | Jmedtech Pte Ltd | Coating |
JP6753041B2 (en) | 2015-08-27 | 2020-09-09 | 住友ゴム工業株式会社 | Surface modification Metal and metal surface modification method |
US11174447B2 (en) | 2015-12-29 | 2021-11-16 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
US10342898B2 (en) | 2015-12-29 | 2019-07-09 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
WO2017132483A1 (en) | 2016-01-29 | 2017-08-03 | Vanderbilt University | Free-solution response function interferometry |
EP4316539A3 (en) | 2016-02-23 | 2024-04-10 | Hollister Incorporated | Medical device with hydrophilic coating |
JP6776029B2 (en) * | 2016-07-06 | 2020-10-28 | テルモ株式会社 | Medical equipment |
EP3984568A1 (en) * | 2016-07-14 | 2022-04-20 | Hollister Incorporated | Hygienic medical devices having hydrophilic coatings and methods of forming the same |
AU2017299466B2 (en) | 2016-07-18 | 2022-07-14 | Merit Medical Systems, Inc. | Inflatable radial artery compression device |
US20180140321A1 (en) | 2016-11-23 | 2018-05-24 | C. R. Bard, Inc. | Catheter With Retractable Sheath And Methods Thereof |
US11596726B2 (en) | 2016-12-17 | 2023-03-07 | C.R. Bard, Inc. | Ultrasound devices for removing clots from catheters and related methods |
US10758256B2 (en) | 2016-12-22 | 2020-09-01 | C. R. Bard, Inc. | Ultrasonic endovascular catheter |
US10582983B2 (en) | 2017-02-06 | 2020-03-10 | C. R. Bard, Inc. | Ultrasonic endovascular catheter with a controllable sheath |
US20180340046A1 (en) | 2017-05-27 | 2018-11-29 | Poly Group LLC | Dispersible antimicrobial complex and coatings therefrom |
EP3638740A1 (en) | 2017-06-16 | 2020-04-22 | Poly Group LLC | Polymeric antimicrobial surfactant |
BR112020014547B1 (en) * | 2018-02-20 | 2023-11-07 | Terumo Kabushiki Kaisha | MEDICAL DEVICE |
FR3085164B1 (en) | 2018-08-22 | 2021-02-26 | Natvi | LUBRICATION PROCESS |
US11628466B2 (en) | 2018-11-29 | 2023-04-18 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
WO2021055759A1 (en) | 2019-09-20 | 2021-03-25 | Glyscend, Inc. | Substituted phenyl boronic acid containing polymers and methods of use |
CN113663130A (en) * | 2020-05-13 | 2021-11-19 | 脉通医疗科技(嘉兴)有限公司 | Artificial blood vessel and preparation method thereof |
CN114177361A (en) * | 2021-11-22 | 2022-03-15 | 禾木(中国)生物工程有限公司 | Drug balloon and preparation method thereof |
CN114891132A (en) * | 2022-06-28 | 2022-08-12 | 矿冶科技集团有限公司 | High-transparency cationic guar gum and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0106004A1 (en) * | 1981-05-18 | 1984-04-25 | Astra Tech Aktiebolag | Method of forming a hydrophilic coating on a substrate |
EP0389632A1 (en) * | 1988-08-09 | 1990-10-03 | Toray Industries, Inc. | Slippery medical material and process for its production |
WO1996023601A1 (en) * | 1995-02-01 | 1996-08-08 | Schneider (Usa) Inc. | Hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(n-vinylpyrrolidone) polymer hydrogel |
EP0728487A1 (en) * | 1995-02-22 | 1996-08-28 | Meadox Medicals, Inc. | A method of providing a substrate with a hydro-philic coating and substrates, particularly medical devices, provided with such coatings |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3695921A (en) | 1970-09-09 | 1972-10-03 | Nat Patent Dev Corp | Method of coating a catheter |
CS154977B1 (en) | 1971-10-08 | 1974-04-30 | ||
US4055682A (en) | 1971-11-19 | 1977-10-25 | High Voltage Engineering Corporation | Catheter and the method of making |
AU494547B2 (en) | 1972-07-10 | 1977-10-20 | Johnson & Johnson | Hydrophilic random interpolymer compositions and method for making same |
US3886947A (en) | 1973-04-13 | 1975-06-03 | Meadox Medicals Inc | Non-thrombogenic catheter |
NL7707669A (en) | 1977-07-08 | 1979-01-10 | Akzo Nv | METHOD OF COVERING A SUBSTRATE WITH A RADIATION HARDABLE COATING COMPOSITION. |
US4100309A (en) | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
CA1109580A (en) * | 1977-11-03 | 1981-09-22 | Kohtaro Nagasawa | Radiation curable resin composition |
SE448544B (en) | 1979-12-05 | 1987-03-02 | Kendall & Co | WATER ABSORPTION COMPOSITION AND USE THEREOF AS A CARRIER FOR A MEDICINE |
US4656252A (en) | 1980-01-24 | 1987-04-07 | Giese Roger W | Amidobiotin compounds useful in a avidin-biotin multiple layering process |
US4282287A (en) | 1980-01-24 | 1981-08-04 | Giese Roger W | Biochemical avidin-biotin multiple-layer system |
USRE31712E (en) * | 1980-01-24 | 1984-10-23 | Biochemical avidin-biotin multiple-layer system | |
IL63638A0 (en) * | 1980-09-16 | 1981-11-30 | Aligena Ag | Semipermeable composite membranes,their manufacture and their use |
US4530974A (en) | 1981-03-19 | 1985-07-23 | Board Of Regents, The University Of Texas System | Nonthrombogenic articles having enhanced albumin affinity |
US4500688A (en) | 1982-04-20 | 1985-02-19 | Petrarch Systems Inc. | Curable silicone containing compositions and methods of making same |
SE430695B (en) | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | PROCEDURE FOR THE PREPARATION OF A HYDROPHILIC COATING AND ACCORDING TO THE PROCEDURE OF MEDICAL ARTICLES |
US4459326A (en) | 1982-05-19 | 1984-07-10 | Hillyard Enterprises, Inc. | Coating of synthetic surfaces with water-based coatings |
US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US4722906A (en) | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US4521564A (en) | 1984-02-10 | 1985-06-04 | Warner-Lambert Company | Covalent bonded antithrombogenic polyurethane material |
DE3582754D1 (en) | 1984-06-04 | 1991-06-13 | Terumo Corp | MEDICAL TOOL AND PRODUCTION METHOD. |
US5023114A (en) | 1984-08-23 | 1991-06-11 | Gregory Halpern | Method of hydrophilic coating of plastics |
US5037677A (en) | 1984-08-23 | 1991-08-06 | Gregory Halpern | Method of interlaminar grafting of coatings |
SE444950B (en) * | 1984-09-28 | 1986-05-20 | Ytkemiska Inst | COVERED ARTICLE, PROCEDURES AND METHODS OF PRODUCING THEREOF AND USING THEREOF |
US4664658A (en) | 1984-11-08 | 1987-05-12 | Mitsubishi Monsanto Chemical Company | Medical material and process for its production |
SE8504501D0 (en) | 1985-09-30 | 1985-09-30 | Astra Meditec Ab | METHOD OF FORMING AN IMPROVED HYDROPHILIC COATING ON A POLYMER SURFACE |
US4729914A (en) | 1985-12-30 | 1988-03-08 | Tyndale Plains-Hunter Ltd. | Hydrophilic coating and substrate coated therewith |
US5108923A (en) | 1986-04-25 | 1992-04-28 | Collaborative Research, Inc. | Bioadhesives for cell and tissue adhesion |
GB8611838D0 (en) | 1986-05-15 | 1986-06-25 | Yarsley Technical Centre Ltd | Hydrophilic copolymers |
US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
US5263992A (en) | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
US5094876A (en) | 1987-04-10 | 1992-03-10 | University Of Florida | Surface modified surgical instruments, devices, implants, contact lenses and the like |
US5290548A (en) | 1987-04-10 | 1994-03-01 | University Of Florida | Surface modified ocular implants, surgical instruments, devices, prostheses, contact lenses and the like |
US5100689A (en) | 1987-04-10 | 1992-03-31 | University Of Florida | Surface modified surgical instruments, devices, implants, contact lenses and the like |
US4870160A (en) | 1987-08-19 | 1989-09-26 | Regents Of The University Of Minnesota | Polypeptides with laminin activity |
US5171271A (en) | 1987-08-25 | 1992-12-15 | Regents Of The University Of Minnesota | Polypeptides with fibronectin activity |
US5294551A (en) | 1987-08-25 | 1994-03-15 | Regents Of The University Of Minnesota | Cell culture substrate coated with polypeptides having fibronectin activity |
US5147797A (en) | 1987-08-25 | 1992-09-15 | Regents Of The University Of Minnesota | Polypeptides with fibronectin activity |
US5116368A (en) | 1987-08-25 | 1992-05-26 | Regents Of The University Of Minnesota | Polypeptides with fibronectin activity |
US4876332A (en) | 1987-10-08 | 1989-10-24 | Regents Of The Univeristy Of Minnesota | Polypeptides with type IV collagen activity |
CA1312277C (en) | 1987-12-18 | 1993-01-05 | Richard C. Sutton | Avidin- and biotin-immobilized reagents, analytical elements and methods of use |
DE68927479T2 (en) | 1988-05-02 | 1997-04-03 | Phanos Tech Inc | CONNECTIONS, COMPOSITIONS AND METHOD FOR BINDING ORGANIC AFFECTION SUBSTANCES TO SURFACE MEMBRANES OF BIOPARTICLES |
US5167960A (en) | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
US5840293A (en) | 1988-11-16 | 1998-11-24 | Advanced Polymer Systems, Inc. | Ionic beads for controlled release and adsorption |
US4978481A (en) * | 1989-01-13 | 1990-12-18 | Ciba-Geigy Corporation | Process for the encapsulation of preformed substrates by graft copolymerization |
US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
ATE153673T1 (en) | 1989-01-27 | 1997-06-15 | Au Membrane & Biotech Res Inst | RECEPTOR MEMBRANES AND SELECTIVE CONTROL OF ION FLOW THROUGH IONOPHORES |
AU649949B2 (en) | 1989-02-03 | 1994-06-09 | Commonwealth Scientific And Industrial Research Organisation | Monoclonal antibodies directed against vitronectin and fibronectin, and uses thereof |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5698531A (en) | 1989-03-31 | 1997-12-16 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5041100A (en) | 1989-04-28 | 1991-08-20 | Cordis Corporation | Catheter and hydrophilic, friction-reducing coating thereon |
US5272012A (en) | 1989-06-23 | 1993-12-21 | C. R. Bard, Inc. | Medical apparatus having protective, lubricious coating |
US5026607A (en) | 1989-06-23 | 1991-06-25 | C. R. Bard, Inc. | Medical apparatus having protective, lubricious coating |
US5278063A (en) | 1989-09-28 | 1994-01-11 | Board Of Regents The University Of Texas System | Chemical modification of promote animal cell adhesion on surfaces |
US5188959A (en) | 1989-09-28 | 1993-02-23 | Trustees Of Tufts College | Extracellular matrix protein adherent t cells |
US5118779A (en) * | 1989-10-10 | 1992-06-02 | Polymedica Industries, Inc. | Hydrophilic polyurethane elastomers |
US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
US5081031A (en) | 1989-12-14 | 1992-01-14 | Regents Of The University Of Minnesota | Synthetic polypeptide with type iv collagen activity |
US5152784A (en) | 1989-12-14 | 1992-10-06 | Regents Of The University Of Minnesota | Prosthetic devices coated with a polypeptide with type IV collagen activity |
US5135516A (en) | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
DK146790D0 (en) * | 1990-06-15 | 1990-06-15 | Meadox Surgimed As | PROCEDURE FOR THE PREPARATION OF A FERTILIZER COATING COATING AND MEDICAL INSTRUMENT WITH COATING COATING |
US5653974A (en) | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
US5160790A (en) * | 1990-11-01 | 1992-11-03 | C. R. Bard, Inc. | Lubricious hydrogel coatings |
US5132108A (en) | 1990-11-08 | 1992-07-21 | Cordis Corporation | Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents |
US5102420A (en) | 1990-11-14 | 1992-04-07 | Ethicon, Inc. | Suture coated with a polyetheramide |
US5295978A (en) | 1990-12-28 | 1994-03-22 | Union Carbide Chemicals & Plastics Technology Corporation | Biocompatible hydrophilic complexes and process for preparation and use |
JP2957021B2 (en) | 1991-01-25 | 1999-10-04 | テルモ株式会社 | Medical material, medical device, and method of manufacturing medical material |
EP0521605A3 (en) | 1991-05-16 | 1993-03-10 | Ioptex Research Inc. | Biocompatible lubricious grafts |
CA2082411A1 (en) | 1991-06-28 | 1992-12-29 | Robert D. Rosenberg | Localized oligonucleotide therapy |
AU2499892A (en) | 1991-08-23 | 1993-03-16 | Board Of Regents Of The University Of Nebraska, The | Method and compositions for cellular reprogramming |
US5654284A (en) | 1991-10-15 | 1997-08-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity |
US5661133B1 (en) | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
CA2100970A1 (en) | 1991-12-18 | 1993-06-19 | Paul J. Buscemi | Lubricous polyer network |
US5756476A (en) | 1992-01-14 | 1998-05-26 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell proliferation using antisense oligonucleotides |
US5571166A (en) | 1992-03-19 | 1996-11-05 | Medtronic, Inc. | Method of making an intraluminal stent |
US5512474A (en) | 1992-05-29 | 1996-04-30 | Bsi Corporation | Cell culture support containing a cell adhesion factor and a positively-charged molecule |
DK172393B1 (en) | 1992-06-10 | 1998-05-18 | Maersk Medical As | Process for producing an article having friction-reducing surface coating, coating material for use in the manufacture of such article, and using an osmolality-increasing compound in slurry or emulsified form in the coating material |
US5383928A (en) | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
US5656609A (en) | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
US5409731A (en) * | 1992-10-08 | 1995-04-25 | Tomei Sangyo Kabushiki Kaisha | Method for imparting a hydrophilic nature to a contact lens |
AU5537994A (en) | 1992-10-22 | 1994-05-09 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
US5350800A (en) | 1993-01-19 | 1994-09-27 | Medtronic, Inc. | Method for improving the biocompatibility of solid surfaces |
SE500964C2 (en) | 1993-01-19 | 1994-10-10 | Medicarb Ab | Solid surface modified carrier wherein the modification is effected by a primer containing a polysaccharide and process for producing such a carrier |
CA2114697C (en) | 1993-02-08 | 2006-06-13 | Kenichi Shimura | Medical tool having lubricious surface in a wetted state and method for production thereof |
US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
US5531715A (en) | 1993-05-12 | 1996-07-02 | Target Therapeutics, Inc. | Lubricious catheters |
NO931809L (en) * | 1993-05-19 | 1994-11-21 | Norsk Hydro As | hemophilia |
AU689786B2 (en) | 1993-06-30 | 1998-04-09 | Genentech Inc. | Method for preparing liposomes |
US5639872A (en) | 1993-07-27 | 1997-06-17 | Hybridon, Inc. | Human VEGF-specific oligonucleotides |
US5663450A (en) | 1993-08-17 | 1997-09-02 | Cv Therapeutics | Macrophage lipid chemoattractant |
JPH09510433A (en) | 1993-12-17 | 1997-10-21 | マイクロパック インコーポレイテッド | Methods for delivering biologically active substances to cells |
US5470307A (en) | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
US5505713A (en) | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
DE69527141T2 (en) | 1994-04-29 | 2002-11-07 | Scimed Life Systems Inc | STENT WITH COLLAGEN |
US5656612A (en) | 1994-05-31 | 1997-08-12 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
US5681278A (en) | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
US5670558A (en) | 1994-07-07 | 1997-09-23 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
US5509899A (en) | 1994-09-22 | 1996-04-23 | Boston Scientific Corp. | Medical device with lubricious coating |
US5652225A (en) | 1994-10-04 | 1997-07-29 | St. Elizabeth's Medical Center Of Boston, Inc. | Methods and products for nucleic acid delivery |
US5643580A (en) | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
US5519020A (en) | 1994-10-28 | 1996-05-21 | The University Of Akron | Polymeric wound healing accelerators |
US5656611A (en) | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
US5665591A (en) | 1994-12-06 | 1997-09-09 | Trustees Of Boston University | Regulation of smooth muscle cell proliferation |
US5660855A (en) | 1995-02-10 | 1997-08-26 | California Institute Of Technology | Lipid constructs for targeting to vascular smooth muscle tissue |
US5575818A (en) | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
US5869127A (en) | 1995-02-22 | 1999-02-09 | Boston Scientific Corporation | Method of providing a substrate with a bio-active/biocompatible coating |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US5665077A (en) | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US5567828A (en) | 1995-06-07 | 1996-10-22 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side |
US5607475A (en) * | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
US5672638A (en) * | 1995-08-22 | 1997-09-30 | Medtronic, Inc. | Biocompatability for solid surfaces |
US5603991A (en) | 1995-09-29 | 1997-02-18 | Target Therapeutics, Inc. | Method for coating catheter lumens |
US5728420A (en) * | 1996-08-09 | 1998-03-17 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins to surfaces of medical devices |
US5670161A (en) | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
US5811151A (en) | 1996-05-31 | 1998-09-22 | Medtronic, Inc. | Method of modifying the surface of a medical device |
US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
US5800412A (en) | 1996-10-10 | 1998-09-01 | Sts Biopolymers, Inc. | Hydrophilic coatings with hydrating agents |
-
1998
- 1998-01-30 US US09/016,694 patent/US6221425B1/en not_active Expired - Lifetime
- 1998-12-31 AU AU20192/99A patent/AU2019299A/en not_active Abandoned
- 1998-12-31 WO PCT/US1998/027731 patent/WO1999038545A1/en active Application Filing
-
1999
- 1999-01-29 EP EP99905536A patent/EP1051208B1/en not_active Expired - Lifetime
- 1999-01-29 AT AT99905536T patent/ATE330646T1/en not_active IP Right Cessation
- 1999-01-29 JP JP2000529277A patent/JP2002501788A/en not_active Withdrawn
- 1999-01-29 US US09/240,914 patent/US6287285B1/en not_active Expired - Lifetime
- 1999-01-29 WO PCT/US1999/001919 patent/WO1999038546A1/en active IP Right Grant
- 1999-01-29 CA CA002316223A patent/CA2316223A1/en not_active Abandoned
- 1999-01-29 AU AU25677/99A patent/AU745979B2/en not_active Ceased
- 1999-01-29 DE DE69932034T patent/DE69932034T2/en not_active Expired - Lifetime
-
2001
- 2001-07-25 US US09/915,413 patent/US6656517B2/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0106004A1 (en) * | 1981-05-18 | 1984-04-25 | Astra Tech Aktiebolag | Method of forming a hydrophilic coating on a substrate |
EP0389632A1 (en) * | 1988-08-09 | 1990-10-03 | Toray Industries, Inc. | Slippery medical material and process for its production |
WO1996023601A1 (en) * | 1995-02-01 | 1996-08-08 | Schneider (Usa) Inc. | Hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(n-vinylpyrrolidone) polymer hydrogel |
EP0728487A1 (en) * | 1995-02-22 | 1996-08-28 | Meadox Medicals, Inc. | A method of providing a substrate with a hydro-philic coating and substrates, particularly medical devices, provided with such coatings |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001023015A1 (en) * | 1999-09-28 | 2001-04-05 | Scimed Life Systems, Inc. | Hydrophilic lubricant coatings for medical devices |
US6458867B1 (en) | 1999-09-28 | 2002-10-01 | Scimed Life Systems, Inc. | Hydrophilic lubricant coatings for medical devices |
EP1917986A3 (en) * | 1999-09-28 | 2010-08-04 | Boston Scientific Scimed, Inc. | Hydrophilic lubricant coatings for medical devices |
EP2103317A1 (en) | 2008-03-20 | 2009-09-23 | Bayer MaterialScience AG | Medical devices with hydrophilic coatings |
EP2103318A1 (en) | 2008-03-20 | 2009-09-23 | Bayer MaterialScience AG | Medical devices with hydrophilic coatings |
US8791200B2 (en) | 2008-09-04 | 2014-07-29 | Bayer Materialscience Ag | TCD based hydrophilic polyurethane dispersions |
US8795830B2 (en) | 2009-01-09 | 2014-08-05 | Dsm Ip Assets B.V. | Primer for coating coiled wires |
CN106334219A (en) * | 2016-08-25 | 2017-01-18 | 百诺奥医学科技(苏州)有限公司 | Hyaluronic acid modified hydrophilic lubricating coating, preparation method and applications thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1051208A1 (en) | 2000-11-15 |
EP1051208B1 (en) | 2006-06-21 |
AU2567799A (en) | 1999-08-16 |
US6221425B1 (en) | 2001-04-24 |
WO1999038546A1 (en) | 1999-08-05 |
JP2002501788A (en) | 2002-01-22 |
ATE330646T1 (en) | 2006-07-15 |
CA2316223A1 (en) | 1999-08-05 |
US20020002353A1 (en) | 2002-01-03 |
AU2019299A (en) | 1999-08-16 |
DE69932034D1 (en) | 2006-08-03 |
US6656517B2 (en) | 2003-12-02 |
DE69932034T2 (en) | 2007-06-28 |
AU745979B2 (en) | 2002-04-11 |
US6287285B1 (en) | 2001-09-11 |
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