WO1998036763A1 - Treatment of infertility with leptin receptor ligands - Google Patents
Treatment of infertility with leptin receptor ligands Download PDFInfo
- Publication number
- WO1998036763A1 WO1998036763A1 PCT/US1998/002909 US9802909W WO9836763A1 WO 1998036763 A1 WO1998036763 A1 WO 1998036763A1 US 9802909 W US9802909 W US 9802909W WO 9836763 A1 WO9836763 A1 WO 9836763A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- leptin receptor
- leptin
- puberty
- treating
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002281888A CA2281888A1 (en) | 1997-02-25 | 1998-02-24 | Treatment of infertility with leptin receptor ligands |
AU66560/98A AU6656098A (en) | 1997-02-25 | 1998-02-24 | Treatment of infertility with leptin receptor ligands |
JP53675198A JP2001512483A (en) | 1997-02-25 | 1998-02-24 | Treatment of infertility with leptin receptor ligand |
EP98908555A EP0991419A1 (en) | 1997-02-25 | 1998-02-24 | Treatment of infertility with leptin receptor ligands |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80610497A | 1997-02-25 | 1997-02-25 | |
US08/806,104 | 1997-02-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998036763A1 true WO1998036763A1 (en) | 1998-08-27 |
WO1998036763A9 WO1998036763A9 (en) | 1999-02-11 |
Family
ID=25193331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/002909 WO1998036763A1 (en) | 1997-02-25 | 1998-02-24 | Treatment of infertility with leptin receptor ligands |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0991419A1 (en) |
JP (1) | JP2001512483A (en) |
AU (1) | AU6656098A (en) |
CA (1) | CA2281888A1 (en) |
WO (1) | WO1998036763A1 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043652A2 (en) * | 2001-11-21 | 2003-05-30 | Yeda Research And Development Co. Ltd | The use of leptin in fertility |
US7166434B2 (en) | 1996-05-29 | 2007-01-23 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
WO2007025349A1 (en) * | 2005-09-01 | 2007-03-08 | The University Of New England | Modulating ovulation and growth rates |
US7786265B2 (en) | 1998-08-21 | 2010-08-31 | Albany Medical College | Isolated antibodies against biologically active leptin-related peptides |
US7790683B2 (en) | 1998-08-21 | 2010-09-07 | Albany Medical College | Leptin-related peptides |
US7875587B2 (en) | 1999-03-29 | 2011-01-25 | Uutech Limited | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
EP2330125A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
EP2330124A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
EP2390264A1 (en) | 2005-02-11 | 2011-11-30 | Amylin Pharmaceuticals Inc. | GIP analog and hybrid polypeptides with selectable propperties |
US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
EP2417980A1 (en) | 2004-02-11 | 2012-02-15 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
CN104360086A (en) * | 2014-12-05 | 2015-02-18 | 重庆中元生物技术有限公司 | Kit for detecting soluble leptin receptor (sOB-R) by latex enhanced turbidimetric immunoassay |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023815A1 (en) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Ob gene product antibodies |
WO1996034885A2 (en) * | 1995-05-05 | 1996-11-07 | Smithkline Beecham Plc | Biologically active peptide fragments of ob protein |
WO1996035787A1 (en) * | 1995-05-08 | 1996-11-14 | Chiron Corporation | Nucleic acids for treating obesity |
WO1996040912A1 (en) * | 1995-06-07 | 1996-12-19 | Amgen Inc. | Ob protein compositions and method |
WO1997000319A2 (en) * | 1995-06-13 | 1997-01-03 | Smithkline Beecham Plc | Chimeric leptin fused to immunoglobulin domain and use |
-
1998
- 1998-02-24 JP JP53675198A patent/JP2001512483A/en active Pending
- 1998-02-24 EP EP98908555A patent/EP0991419A1/en not_active Withdrawn
- 1998-02-24 WO PCT/US1998/002909 patent/WO1998036763A1/en not_active Application Discontinuation
- 1998-02-24 CA CA002281888A patent/CA2281888A1/en not_active Abandoned
- 1998-02-24 AU AU66560/98A patent/AU6656098A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023815A1 (en) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Ob gene product antibodies |
WO1996034885A2 (en) * | 1995-05-05 | 1996-11-07 | Smithkline Beecham Plc | Biologically active peptide fragments of ob protein |
WO1996035787A1 (en) * | 1995-05-08 | 1996-11-14 | Chiron Corporation | Nucleic acids for treating obesity |
WO1996040912A1 (en) * | 1995-06-07 | 1996-12-19 | Amgen Inc. | Ob protein compositions and method |
WO1997000319A2 (en) * | 1995-06-13 | 1997-01-03 | Smithkline Beecham Plc | Chimeric leptin fused to immunoglobulin domain and use |
Non-Patent Citations (13)
Title |
---|
AHIMA R. S., ET AL.: "LEPTIN ACCELERATES THE ONSET OF PUBERTY IN NORMAL FEMALE MICE.", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 99., no. 03., 1 February 1997 (1997-02-01), US, pages 391 - 395., XP002910923, ISSN: 0021-9738, DOI: 10.1172/JCI119172 * |
AHIMA R. S., ET AL.: "ROLE OF LEPTIN IN THE NEUROENDOCRINE RESPONSE TO FASTING.", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 382., no. 6588., 18 July 1996 (1996-07-18), United Kingdom, pages 250 - 252., XP002910922, ISSN: 0028-0836, DOI: 10.1038/382250a0 * |
BARASH I. A., ET AL.: "LEPTIN IS A METABOLIC SIGNAL TO THE REPRODUCTIVE SYSTEM.", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 137., no. 07., 1 July 1996 (1996-07-01), US, pages 3144 - 3147., XP002910929, ISSN: 0013-7227, DOI: 10.1210/en.137.7.3144 * |
BRZECHFA P. R., ET AL.: "SERUM IMMUNOREACTIVE LEPTIN CONCENTRATIONS IN WOMEN WITH POLYCYSTICOVARY SYNDROME.", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 81., no. 11., 1 November 1996 (1996-11-01), US, pages 4166 - 4169., XP002910933, ISSN: 0021-972X, DOI: 10.1210/jc.81.11.4166 * |
BUTTE N. F., HOPKINSON J. M., NICOLSON M. A.: "LEPTIN IN HUMAN REPRODUCTION: SERUM LEPTIN LEVELS IN PREGNANT AND LACTATING WOMEN.", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 89., no. 02., 1 February 1997 (1997-02-01), US, pages 585 - 589., XP002910927, ISSN: 0021-972X, DOI: 10.1210/jc.82.2.585 * |
CHEHAB F. F., ET AL.: "CORRECTION OF THE STERILITY DEFECT IN HOMOZYGOUS OBESE FEMALE MICE BY TREATMENT WITH THE HUMAN RECOMBINANT LEPTIN.", NATURE GENETICS., NATURE PUBLISHING GROUP, NEW YORK, US, vol. 12., no. 03., 1 March 1996 (1996-03-01), NEW YORK, US, pages 318 - 320., XP002910930, ISSN: 1061-4036, DOI: 10.1038/ng0396-318 * |
CHEHAB F. F., ET AL.: "EARLY ONSET REPRODUCTIVE FUNCTION IN NORMAL FEMALE MICE TREATED WITH LEPTIN", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 275., 3 January 1997 (1997-01-03), US, pages 88 - 90., XP002910924, ISSN: 0036-8075, DOI: 10.1126/science.275.5296.88 * |
CHEHAB F.: "A BROADER ROLE FOR LEPTIN.", NATURE MEDICINE., NATURE PUBLISHING GROUP, NEW YORK, NY., US, vol. 12., no. 03., 1 July 1996 (1996-07-01), US, pages 723/724., XP002910931, ISSN: 1078-8956, DOI: 10.1038/nm0796-723b * |
CHEUNG C. C., ET AL.: "LEPTIN IS A METABOLIC GATE FOR THE ONSET OF PUBERTY IN THE FEMALE RAT.", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 138., no. 02., 1 February 1997 (1997-02-01), US, pages 855 - 858., XP002910926, ISSN: 0013-7227, DOI: 10.1210/en.138.2.855 * |
HAMILTON B. S.: "A NEW ROLE FOR A FAT ACTOR.", NATURE MEDICINE., NATURE PUBLISHING GROUP, NEW YORK, NY., US, vol. 02., no. 03., 1 March 1996 (1996-03-01), US, pages 372/373., XP002910932, ISSN: 1078-8956, DOI: 10.1038/nm0396-272 * |
HASSINK S. G., ET AL.: "SERUM LEPTIN IN CHILDREN WITH OBESITY: RELATIONSHIP TO GENDER AND DEVELOPMENT.", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, EVANSTON, IL,, US, vol. 98., no. 02., 1 August 1996 (1996-08-01), US, pages 201 - 203., XP002910921, ISSN: 0031-4005 * |
VOGEL G.: "NEUROSCIENCE'S MEETING OF THE MINDS IN WASHINGTON.", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 274., 29 November 1996 (1996-11-29), US, pages 1466/1467., XP002910925, ISSN: 0036-8075, DOI: 10.1126/science.274.5292.1466c * |
YU W. H., ET AL.: "ROLE OF LEPTIN IN HYPOTHALAMIC-PITUITARY FUNCTION.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 94., 1 February 1997 (1997-02-01), US, pages 1023 - 1028., XP002910928, ISSN: 0027-8424, DOI: 10.1073/pnas.94.3.1023 * |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7166434B2 (en) | 1996-05-29 | 2007-01-23 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US7790683B2 (en) | 1998-08-21 | 2010-09-07 | Albany Medical College | Leptin-related peptides |
US8067545B2 (en) | 1998-08-21 | 2011-11-29 | Albany Medical College | Isolated antibodies against biologically active leptin-related peptides |
US8022189B2 (en) | 1998-08-21 | 2011-09-20 | Albany Medical College | Isolated antibodies against biologically active leptin-related peptides |
US7786265B2 (en) | 1998-08-21 | 2010-08-31 | Albany Medical College | Isolated antibodies against biologically active leptin-related peptides |
US7875587B2 (en) | 1999-03-29 | 2011-01-25 | Uutech Limited | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
WO2003043652A3 (en) * | 2001-11-21 | 2004-03-18 | Yeda Res & Dev | The use of leptin in fertility |
AU2002353464B2 (en) * | 2001-11-21 | 2007-01-18 | Yeda Research And Development Co. Ltd | The use of leptin in fertility |
WO2003043652A2 (en) * | 2001-11-21 | 2003-05-30 | Yeda Research And Development Co. Ltd | The use of leptin in fertility |
US9453063B2 (en) | 2004-02-11 | 2016-09-27 | Amylin Pharmaceuticals, Llc. | Hybrid polypeptides with selectable properties |
EP2417980A1 (en) | 2004-02-11 | 2012-02-15 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
US8697647B2 (en) | 2004-02-11 | 2014-04-15 | Odile Esther Levy | Hybrid polypeptides with selectable properties |
EP2422806A2 (en) | 2004-02-11 | 2012-02-29 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
EP2422807A2 (en) | 2004-02-11 | 2012-02-29 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
EP2390264A1 (en) | 2005-02-11 | 2011-11-30 | Amylin Pharmaceuticals Inc. | GIP analog and hybrid polypeptides with selectable propperties |
EP2392595A1 (en) | 2005-02-11 | 2011-12-07 | Amylin Pharmaceuticals Inc. | GIP analog and hybrid polypeptides with selectable properties |
US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
US8404637B2 (en) | 2005-02-11 | 2013-03-26 | Amylin Pharmaceuticals, Llc | GIP analog and hybrid polypeptides with selectable properties |
US8895498B2 (en) | 2005-02-11 | 2014-11-25 | Astrazeneca Pharmaceuticals, Lp | GIP and exendin hybrid polypeptides |
US9133260B2 (en) | 2005-02-11 | 2015-09-15 | Amylin Pharmaceuticals, Llc | GIP analog and hybrid polypeptides with selectable properties |
EP2330124A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
EP2330125A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
WO2007025349A1 (en) * | 2005-09-01 | 2007-03-08 | The University Of New England | Modulating ovulation and growth rates |
US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
CN104360086A (en) * | 2014-12-05 | 2015-02-18 | 重庆中元生物技术有限公司 | Kit for detecting soluble leptin receptor (sOB-R) by latex enhanced turbidimetric immunoassay |
Also Published As
Publication number | Publication date |
---|---|
CA2281888A1 (en) | 1998-08-27 |
AU6656098A (en) | 1998-09-09 |
EP0991419A1 (en) | 2000-04-12 |
JP2001512483A (en) | 2001-08-21 |
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