WO1998030255A3 - Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels - Google Patents

Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels Download PDF

Info

Publication number
WO1998030255A3
WO1998030255A3 PCT/US1998/000491 US9800491W WO9830255A3 WO 1998030255 A3 WO1998030255 A3 WO 1998030255A3 US 9800491 W US9800491 W US 9800491W WO 9830255 A3 WO9830255 A3 WO 9830255A3
Authority
WO
WIPO (PCT)
Prior art keywords
restenosis
blood vessels
inhibition
intravascular delivery
antioxidant substances
Prior art date
Application number
PCT/US1998/000491
Other languages
French (fr)
Other versions
WO1998030255A2 (en
WO1998030255A9 (en
Inventor
Aaron V Kaplan
Original Assignee
Localmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Localmed Inc filed Critical Localmed Inc
Priority to AU59593/98A priority Critical patent/AU5959398A/en
Publication of WO1998030255A2 publication Critical patent/WO1998030255A2/en
Publication of WO1998030255A3 publication Critical patent/WO1998030255A3/en
Publication of WO1998030255A9 publication Critical patent/WO1998030255A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Restenosis in re-canalized blood vessels is inhibited by an antioxidant substance, such as probucol, intramurally at a target site within the blood vessel. Usually, the antioxidant substance is delivered using a catheter having infusion ports at its distal end. Optionally, the distal end of the catheter (110) is radially expanded to engage the infusion ports directly against the blood vessel wall. Delivery of the antioxidant substance may be effected before, during, or after the re-canalization procedure.
PCT/US1998/000491 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels WO1998030255A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59593/98A AU5959398A (en) 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3469397P 1997-01-09 1997-01-09
US60/034,693 1997-01-09

Publications (3)

Publication Number Publication Date
WO1998030255A2 WO1998030255A2 (en) 1998-07-16
WO1998030255A3 true WO1998030255A3 (en) 1998-11-12
WO1998030255A9 WO1998030255A9 (en) 1998-12-23

Family

ID=21878006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000491 WO1998030255A2 (en) 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels

Country Status (2)

Country Link
AU (1) AU5959398A (en)
WO (1) WO1998030255A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
NZ528906A (en) 1997-05-14 2005-06-24 Atherogenics Inc Compounds and methods for the inhibition of the expression of VCAM-1
WO2000010552A2 (en) * 1998-08-24 2000-03-02 Global Vascular Concepts, Inc. Use of anti-angiogenic agents for inhibiting vessel wall injury
WO2001077072A2 (en) 2000-04-11 2001-10-18 Atherogenics, Inc. Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality
FI20010898A0 (en) * 2001-04-30 2001-04-30 Ylae Herttuala Seppo Extracellular superoxide dismutase (EC-SOD) gene therapy to prevent restenosis
EP1499344A1 (en) * 2002-04-30 2005-01-26 FIT Biotech Oyj Plc Medical device
CA2536961A1 (en) * 2003-08-14 2005-02-24 Blue Medical Devices B.V. Endoluminal prosthesis comprising a therapeutic agent
AU2013300055A1 (en) * 2012-08-06 2015-02-26 South Dakota Board Of Regents Ascorbic acid-eluting implantable medical devices, systems, and related methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage

Also Published As

Publication number Publication date
WO1998030255A2 (en) 1998-07-16
AU5959398A (en) 1998-08-03

Similar Documents

Publication Publication Date Title
WO2003002034A3 (en) Peeling sheath for expandable stent
CA2273072A1 (en) Temperature regulating catheter and methods
EP1616563A3 (en) Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases
WO2005077450A3 (en) Intravascular delivery system for therapeutic agents
WO2004028588A3 (en) Blood vessel puncture hemostatisis delivery systems
WO2001021058A3 (en) Device and method for determining a depth of an incision
WO2001034063A3 (en) Protective sheath for catheters
IL133463A0 (en) Implant with deflector for intravascular dilation
AU7094800A (en) Methods and apparatus for treating body tissues and bodily fluid vessels
WO1997048436A3 (en) Externally valved catheter for controlled antegrade and retrograde fluid flow
WO2006017470A3 (en) Device and method for treating a vessel
CA2346640A1 (en) A needle apparatus
WO2004064893A3 (en) Catheter design that facilitates positioning at tissue to be diagnosed or treated
WO2000015148A8 (en) Transmyocardial shunt made with a blood vessel graft for left ventricular revascularization
WO2002051489A3 (en) Tissue attachable drug delivery catheters/methods of use
AU2003287538A1 (en) Apparatus and method for inhibiting blood loss
CA2206078A1 (en) Multi-layer distal catheter section
WO2002039906A3 (en) Method and device for the treatment of vulnerable tissue site
WO2000015149A8 (en) Transmyocardial shunt with valve for left ventricular revascularization
AU2002360367A1 (en) Hemostasis cathter and method
AU7154796A (en) Method and apparatus for conformably sealing prostheses within body lumens
DE60034146D1 (en) ENDOLUMINAL OCCLUSION SPÜLKATHETER
WO2002007786A3 (en) Apparatus and method for introducing an implant
WO2004071612A3 (en) Methods and apparatus for treating the interior of a blood vessel
WO2000021461A3 (en) Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA IL JP KR NZ

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA IL JP KR NZ

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 1/5-5/5, DRAWINGS, REPLACED BY NEW PAGES 1/5-5/5; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998531176

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase