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Publication numberWO1998027969 A3
Publication typeApplication
Application numberPCT/CA1997/000978
Publication date1 Oct 1998
Filing date24 Dec 1997
Priority date24 Dec 1996
Also published asCA2247348A1, WO1998027969A2
Publication numberPCT/1997/978, PCT/CA/1997/000978, PCT/CA/1997/00978, PCT/CA/97/000978, PCT/CA/97/00978, PCT/CA1997/000978, PCT/CA1997/00978, PCT/CA1997000978, PCT/CA199700978, PCT/CA97/000978, PCT/CA97/00978, PCT/CA97000978, PCT/CA9700978, WO 1998/027969 A3, WO 1998027969 A3, WO 1998027969A3, WO 9827969 A3, WO 9827969A3, WO-A3-1998027969, WO-A3-9827969, WO1998/027969A3, WO1998027969 A3, WO1998027969A3, WO9827969 A3, WO9827969A3
InventorsDick Zoutman, Kanji Nakatsu, Dragic Vukomanovic, Gerald Marks, James Brien
ApplicantUniv Kingston, Dick Zoutman, Kanji Nakatsu, Dragic Vukomanovic, Gerald Marks, James Brien
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Antimicrobial phenazine compounds
WO 1998027969 A3
Abstract
Phenazine compounds having antimicrobial activity are described. The phenazine compounds can be phenazine N-oxides, including phenazine-5,10-dioxides, which may optionally be substituted at one or more positions, preferably the 7- and/or 8-positions of the phenazine nucleus. Also described are methods for treating microbial infections, and methods for inhibiting the growth of a microbial cell. The microbes treated or inhibited can be multidrug resistant. These compounds also inhibit the growth of tumor cells.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
DE1695429A1 *8 Jun 196715 Apr 1971Merck Patent GmbhVerfahren zur Herstellung von 1-Methoxy-phenazin-5,10-dioxid
FR2134012A1 * Title not available
GB1103137A * Title not available
GB1182617A * Title not available
GB1271194A * Title not available
GB1285010A * Title not available
US3530130 *14 Sep 196722 Sep 1970Hoffmann La Roche1-acylated-6-methoxyphenazine 5,10-dioxides
US3567728 *5 Jul 19682 Mar 1971PfizerProcess for the preparation of phenazine di-n-oxides and related compounds
US3586674 *8 Apr 196922 Jun 1971Hoffmann La RocheOrganometallic derivatives of 6-lower alkoxy 1-phenazinol 5,10-dioxide
US3609153 *20 Apr 196728 Sep 1971Canadian Patents Dev1 hydroxy 6 methoxy phenazines
US3678051 *2 Apr 197018 Jul 1972Hoffmann La RocheDerivatives of 1,6-phenazinediol 5,10-dioxide
US3700679 *8 Jun 197024 Oct 1972Hoffmann La RocheNuclear substituted derivatives of 1-hydroxy-6-methoxyphenazine 5,10-dioxide
US3822265 *14 May 19692 Jul 1974Hoffmann La RochePhenazine derivatives
US3937707 *22 Jul 197410 Feb 1976Hoffmann-La Roche Inc.6-substituted 1-phenazinol 5,10-dioxide derivatives
US3985734 *13 Feb 197412 Oct 1976Hoffmann-La Roche Inc.Method for the preparation of the copper complex of 6-methoxy-1-phenazinol 5,10-dioxide
US5637591 *2 Jun 199510 Jun 1997Fuji Immunopharmaceuticals Corp.Antimicrobial and anticollagenase activity of phenazine-5, 10-dioxide and derivatives
Non-Patent Citations
Reference
1 *GRUNBERG ET AL.: "Studies on the in vitro and in vivo chemotherapeutic properties of the antibiotic Myxin", CHEMOTHERAPIA, vol. 12, no. 5, 1967, pages 272 - 281, XP002062758
2 *MAESTRONE ET AL.: "Chemotherapeutic activity of 6-methoxy-1-phenazinol 5,10-dioxide, cupric complex in experimentally induced local microbial infections in dogs", AM. J. VET. RES., vol. 35, no. 2, 1974, pages 281 - 284, XP002062759
3 *MAESTRONE ET AL.: "Topical antimicrobial activity of 6-Methoxy-1-Phenazinol 5,10-dioxide, cupric complex", AM. J. VET. RES., vol. 33, no. 1, 1972, pages 185 - 193, XP002062754
4 *MAESTRONE TE AL.: "Evaluation of Cuprimyxin-hydrocortisone acetate suspension in the treatment of otitis externa in dogs and cats", AM. J. VET. RES., vol. 40, no. 2, 1979, pages 285 - 287, XP002062755
5 *MCDONALD ET AL.: "Antimicrobial susceptibility of Prototheca zopfii isolated from bovine intramammary infections", AM. J. VET. RES., vol. 45, no. 6, 1984, pages 1079- - 1080, XP002062756
6 *SEKHON ET AL.: "Sensitivity of some human pathogenic yeasts and systemic fungi to myxin", ABSTR. ANNU. MEET. AM. SOC. MICROBIOL., vol. 75, 1975, pages 44, XP002062757
Classifications
International ClassificationA61K31/498
Cooperative ClassificationA61K31/498
European ClassificationA61K31/498
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