WO1997045559A1 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions - Google Patents
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions Download PDFInfo
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- WO1997045559A1 WO1997045559A1 PCT/US1997/009012 US9709012W WO9745559A1 WO 1997045559 A1 WO1997045559 A1 WO 1997045559A1 US 9709012 W US9709012 W US 9709012W WO 9745559 A1 WO9745559 A1 WO 9745559A1
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- oligonucleotide
- primer
- sequences
- polymerase chain
- chain reaction
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6858—Allele-specific amplification
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- C12Q1/6862—Ligase chain reaction [LCR]
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- C12Q1/6869—Methods for sequencing
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU32160/97A AU730633B2 (en) | 1996-05-29 | 1997-05-27 | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
JP54287897A JP4468488B2 (en) | 1996-05-29 | 1997-05-27 | Detection of nucleic acid sequence differences using combined ligase detection and polymerase chain reaction |
EP97927787A EP0912761A4 (en) | 1996-05-29 | 1997-05-27 | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
CA002255774A CA2255774C (en) | 1996-05-29 | 1997-05-27 | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1853296P | 1996-05-29 | 1996-05-29 | |
US60/018,532 | 1996-05-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997045559A1 true WO1997045559A1 (en) | 1997-12-04 |
Family
ID=21788414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/009012 WO1997045559A1 (en) | 1996-05-29 | 1997-05-27 | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
Country Status (6)
Country | Link |
---|---|
US (18) | US6027889A (en) |
EP (3) | EP1736554B1 (en) |
JP (3) | JP4468488B2 (en) |
AU (1) | AU730633B2 (en) |
CA (1) | CA2255774C (en) |
WO (1) | WO1997045559A1 (en) |
Cited By (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0956359A1 (en) * | 1996-07-19 | 1999-11-17 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
WO2000055368A2 (en) * | 1999-03-15 | 2000-09-21 | Pe Corporation (Ny) | Probe/mobility modifier complexes for multiplex nucleic acid detection |
WO2001057269A2 (en) * | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
WO2001057268A2 (en) * | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
EP1130113A1 (en) * | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
EP1136568A1 (en) * | 1999-10-04 | 2001-09-26 | Olympus Optical Corporation Limited | Method of detecting nucleic acid |
WO2001085987A1 (en) * | 2000-05-09 | 2001-11-15 | Diatech Pty. Ltd. | Methods for identifying polynucleotide repeat regions of defined length |
WO2001092579A2 (en) * | 2000-05-30 | 2001-12-06 | Pe Corporation (Ny) | Methods for detecting target nucleic acids using coupled ligation and amplification |
WO2002002815A1 (en) * | 2000-07-05 | 2002-01-10 | Toyo Boseki Kabushiki Kaisha | Method of detecting nucleotide polymorphism |
EP1194592A1 (en) * | 1999-07-14 | 2002-04-10 | Packard Bioscience Company | Derivative nucleic acids and uses thereof |
EP1221491A1 (en) * | 1999-10-12 | 2002-07-10 | Precision System Science Co., Ltd. | SUSPENSION SYSTEM FOR SEQUENCING GENETIC SUBSTANCE, METHOD OF SEQUENCING GENETIC SUBSTANCE BY USING THE SUSPENSION SYSTEM, AND METHOD OF HIGH-SPEED SNPs SCORING BY USING THE SUSPENSION SYSTEM |
EP1229128A1 (en) * | 2001-01-31 | 2002-08-07 | Boehringer Mannheim Gmbh | New method for genotype determination |
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
EP1247815A2 (en) * | 2001-03-25 | 2002-10-09 | Exiqon A/S | Modified oligonucleotides and uses thereof |
JP2003510011A (en) * | 1999-03-19 | 2003-03-18 | コーネル リサーチ ファンデーション インク. | Coupled polymerase chain reaction-restriction endonuclease digestion-ligase detection reaction |
EP1319718A1 (en) * | 2001-12-14 | 2003-06-18 | Keygene N.V. | High throughput analysis and detection of multiple target sequences |
WO2003060163A2 (en) * | 2001-12-28 | 2003-07-24 | Keygene N.V. | Discrimination and detection of target nucleotide sequences using mass spectrometry |
US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
EP1456416A2 (en) * | 2001-11-19 | 2004-09-15 | Parallele Bioscience, Inc. | Multiplex oligonucleotide addition and target amplification |
WO2005021794A2 (en) * | 2003-09-02 | 2005-03-10 | Keygene N.V. | Ola-based methods for the detection of target nucleic acid sequences |
US6949370B1 (en) | 1998-10-30 | 2005-09-27 | Cornell Research Foundation, Inc. | High fidelity thermostable ligase and uses thereof |
WO2005092038A2 (en) * | 2004-03-22 | 2005-10-06 | The Johns Hopkins University | Methods for the detection of nucleic acid differences |
US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
WO2005118862A2 (en) * | 2004-04-30 | 2005-12-15 | Applera Corporation | Compositions, methods, and kits for (mis)ligating oligonucleotides |
WO2006005055A2 (en) * | 2004-06-30 | 2006-01-12 | Applera Corporation | Methods reaction mixtures and kits for ligating polynucleotides |
EP1668148A1 (en) * | 2003-09-04 | 2006-06-14 | Human Genetic Signatures PTY Ltd. | Nucleic acid detection assay |
EP1718766A2 (en) * | 2004-02-10 | 2006-11-08 | Cornell Research Foundation, Inc. | Method for detection of promoter methylation status |
US7285384B2 (en) | 2000-02-16 | 2007-10-23 | Illuminia, Inc. | Parallel genotyping of multiple patient samples |
US7361488B2 (en) | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
WO2008118998A2 (en) * | 2007-03-27 | 2008-10-02 | Primera Biosystems Inc. | Method for multiplex detection and quantitation of nucleic acids |
US7455965B2 (en) | 2000-04-14 | 2008-11-25 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
US7482443B2 (en) * | 2000-03-09 | 2009-01-27 | Genetag Technology, Inc. | Systems and methods to quantify and amplify both signaling probes for cDNA chips and genes expression microarrays |
EP2210665A1 (en) | 2002-01-16 | 2010-07-28 | CLONDIAG GmbH | Apparatus for detecting target molecules |
US7799525B2 (en) | 2003-06-17 | 2010-09-21 | Human Genetic Signatures Pty Ltd. | Methods for genome amplification |
US7803580B2 (en) | 2004-09-10 | 2010-09-28 | Human Genetic Signatures Pty. Ltd. | Amplification blocker comprising intercalating nucleic acids (INA) containing intercalating pseudonucleotides (IPN) |
EP2241639A2 (en) | 2004-01-26 | 2010-10-20 | CLONDIAG GmbH | Method for genotyping and pathotyping pseudomonas aeruginosa |
US7833942B2 (en) | 2004-12-03 | 2010-11-16 | Human Genetic Signatures Pty. Ltd. | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
EP2256478A2 (en) | 2004-05-06 | 2010-12-01 | CLONDIAG GmbH | Device and method for detecting molecular interactions |
EP2266699A1 (en) | 2003-04-02 | 2010-12-29 | CLONDIAG GmbH | Device for the amplification and detection of nucleic acids |
US7887752B2 (en) | 2003-01-21 | 2011-02-15 | Illumina, Inc. | Chemical reaction monitor |
EP2330215A1 (en) | 2005-11-04 | 2011-06-08 | CLONDIAG GmbH | Method and device for the detection of molecular interactions |
EP2356245A1 (en) * | 2008-11-07 | 2011-08-17 | University Of Utah Research Foundation | Allele amplification bias |
US8168777B2 (en) | 2004-04-29 | 2012-05-01 | Human Genetic Signatures Pty. Ltd. | Bisulphite reagent treatment of nucleic acid |
US8236498B2 (en) | 2006-01-20 | 2012-08-07 | Olympus Corporation | Method of detecting nucleotide sequence with an intramolecular probe |
US8343738B2 (en) | 2005-09-14 | 2013-01-01 | Human Genetic Signatures Pty. Ltd. | Assay for screening for potential cervical cancer |
WO2013009175A1 (en) | 2011-07-08 | 2013-01-17 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US8431347B2 (en) | 2005-05-26 | 2013-04-30 | Human Genetic Signatures Pty Ltd | Isothermal strand displacement amplification using primers containing a non-regular base |
WO2013095119A1 (en) | 2011-12-14 | 2013-06-27 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Identification of poliovirus strains |
WO2013128281A1 (en) * | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
CN103388023A (en) * | 2012-05-11 | 2013-11-13 | 科美仪器 | System for integrated analysis of real-time polymerase chain reaction and DNA chip and method for integrated analysis using the same |
US8685675B2 (en) | 2007-11-27 | 2014-04-01 | Human Genetic Signatures Pty. Ltd. | Enzymes for amplification and copying bisulphite modified nucleic acids |
US8691754B2 (en) | 2003-09-22 | 2014-04-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US8691594B2 (en) | 1996-04-25 | 2014-04-08 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US8906626B2 (en) | 2000-02-07 | 2014-12-09 | Illumina, Inc. | Multiplex nucleic acid reactions |
US8993271B2 (en) | 1997-04-01 | 2015-03-31 | Illumina, Inc. | Method of nucleic acid amplification |
EP2893034A1 (en) * | 2012-09-10 | 2015-07-15 | Genesky Diagnostics (Suzhou) Inc. | Method for multiplex nucleic acid analysis |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
WO2015185564A1 (en) * | 2014-06-02 | 2015-12-10 | Base4 Innovation Ltd | Nucleotide polymorphism detection method |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US9279148B2 (en) | 1999-04-20 | 2016-03-08 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US9399795B2 (en) | 1998-06-24 | 2016-07-26 | Illumina, Inc. | Multiplex decoding of array sensors with microspheres |
WO2016121907A1 (en) * | 2015-01-30 | 2016-08-04 | 倉敷紡績株式会社 | Method for preparing single-stranded dna product |
US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
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US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
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US9732375B2 (en) | 2011-09-07 | 2017-08-15 | Human Genetic Signatures Pty. Ltd. | Molecular detection assay using direct treatment with a bisulphite reagent |
WO2018127408A1 (en) | 2017-01-05 | 2018-07-12 | Tervisetehnoloogiate Arenduskeskus As | Quantifying dna sequences |
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US10407717B2 (en) | 2001-11-19 | 2019-09-10 | Affymetrix, Inc. | Methods of analysis of methylation |
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Families Citing this family (677)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6652808B1 (en) * | 1991-11-07 | 2003-11-25 | Nanotronics, Inc. | Methods for the electronic assembly and fabrication of devices |
AU3728093A (en) * | 1992-02-19 | 1993-09-13 | Public Health Research Institute Of The City Of New York, Inc., The | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
EP1736554B1 (en) * | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
WO1998011210A1 (en) * | 1996-09-13 | 1998-03-19 | Laboratory Of Molecular Biophotonics | Solid phase for target nucleic acid detection, process for production thereof, and method of target nucleic acid detection |
GB9624165D0 (en) * | 1996-11-19 | 1997-01-08 | Amdex A S | Use of nucleic acids bound to carrier macromolecules |
WO1998029736A1 (en) | 1996-12-31 | 1998-07-09 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
US7622294B2 (en) * | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
CA2291180A1 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
GB9725197D0 (en) * | 1997-11-29 | 1998-01-28 | Secr Defence | Detection system |
US20030039967A1 (en) * | 1997-12-19 | 2003-02-27 | Kris Richard M. | High throughput assay system using mass spectrometry |
US20030096232A1 (en) * | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
US20100105572A1 (en) * | 1997-12-19 | 2010-04-29 | Kris Richard M | High throughput assay system |
US20020177144A1 (en) * | 1997-12-30 | 2002-11-28 | Jose Remacle | Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc |
US20050053962A1 (en) * | 1998-01-27 | 2005-03-10 | Gary Blackburn | Amplification of nucleic acids with electronic detection |
US6759192B1 (en) * | 1998-06-05 | 2004-07-06 | Genset S.A. | Polymorphic markers of prostate carcinoma tumor antigen-1(PCTA-1) |
US20040203078A1 (en) * | 1998-07-22 | 2004-10-14 | National Institute Of Advanced Industrial Science And Technology | Labeled complex, process for producing same and process for utilizing same |
US6703228B1 (en) | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
EP1001037A3 (en) * | 1998-09-28 | 2003-10-01 | Whitehead Institute For Biomedical Research | Pre-selection and isolation of single nucleotide polymorphisms |
CA2352363A1 (en) * | 1998-11-27 | 2000-06-08 | Synaptics (Uk) Limited | Position sensor |
US7014994B1 (en) | 1999-03-19 | 2006-03-21 | Cornell Research Foundation,Inc. | Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process |
US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US20030215821A1 (en) * | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
WO2000075373A2 (en) | 1999-05-20 | 2000-12-14 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
US8080380B2 (en) * | 1999-05-21 | 2011-12-20 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
JP3911909B2 (en) * | 1999-06-09 | 2007-05-09 | 株式会社日立製作所 | DNA sample preparation method and DNA sample preparation apparatus |
US20020119448A1 (en) * | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
US6692915B1 (en) | 1999-07-22 | 2004-02-17 | Girish N. Nallur | Sequencing a polynucleotide on a generic chip |
ATE542916T1 (en) | 1999-08-18 | 2012-02-15 | Illumina Inc | METHODS FOR GENERATING OLIGONUCLEOTIDE SOLUTIONS |
KR20070112295A (en) * | 1999-09-10 | 2007-11-22 | 제론 코포레이션 | Oligonucleotide n3'→p5' thiophosphoramidates: their synthesis and use |
CN102586228A (en) | 1999-09-13 | 2012-07-18 | 纽亘技术公司 | Methods and composition for linear isothermal amplification of polynucleotide sequences |
US6692918B2 (en) * | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
FR2798673B1 (en) * | 1999-09-16 | 2004-05-28 | Exonhit Therapeutics Sa | METHODS AND COMPOSITIONS FOR DETECTION OF PATHOLOGICAL EVENTS |
EP1257664A4 (en) * | 2000-01-28 | 2006-04-05 | Althea Technologies Inc | Methods for analysis of gene expression |
US6913884B2 (en) * | 2001-08-16 | 2005-07-05 | Illumina, Inc. | Compositions and methods for repetitive use of genomic DNA |
US7955794B2 (en) * | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
US8076063B2 (en) * | 2000-02-07 | 2011-12-13 | Illumina, Inc. | Multiplexed methylation detection methods |
US20050214825A1 (en) * | 2000-02-07 | 2005-09-29 | John Stuelpnagel | Multiplex sample analysis on universal arrays |
US7611869B2 (en) * | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
US6770441B2 (en) * | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
EP1257805B1 (en) * | 2000-02-10 | 2015-10-14 | Illumina, Inc. | Composition comprising a substrate with multiple assay locations for bead-based simultaneous processing of multiple samples, apparatus comprising the composition, and manufacturing method for the composition |
DE10010281B4 (en) * | 2000-02-25 | 2005-03-10 | Epigenomics Ag | Ligase / polymerase method for the detection of cytosine methylation in DNA samples |
US6368801B1 (en) | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
US7087414B2 (en) | 2000-06-06 | 2006-08-08 | Applera Corporation | Methods and devices for multiplexing amplification reactions |
US7892854B2 (en) * | 2000-06-21 | 2011-02-22 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
US7846733B2 (en) * | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
DE60141087D1 (en) | 2000-06-26 | 2010-03-04 | Nugen Technologies Inc | METHODS AND COMPOSITIONS FOR TRANSCRIPTION-REPRODUCTIVE MACHINING OF NUCLEIC ACIDS |
DE50108396D1 (en) * | 2000-07-01 | 2006-01-19 | Clondiag Chip Tech Gmbh | PROCESS FOR THE QUALITATIVE AND / OR QUANTITATIVE DETECTION OF MOLECULAR INTERACTIONS ON PROBE ARRAYS |
WO2002002823A2 (en) * | 2000-07-03 | 2002-01-10 | Applera Corporation | Polynucleotide sequence assay |
SG144729A1 (en) * | 2000-07-06 | 2008-08-28 | Bio Merieux | Method for controlling the microbiological quality of an aqueous medium and kit therefor |
US20050260574A1 (en) * | 2000-07-27 | 2005-11-24 | Gibbs Mark J | Combinatorial probes and uses therefor |
AU2001285155A1 (en) * | 2000-08-21 | 2002-03-04 | Lynx Therapeutics, Inc. | Polymorphic dna fragments and uses thereof |
US20050272085A1 (en) * | 2000-09-06 | 2005-12-08 | Hodge Timothy A | Methods for forensic and congenic screening |
EP1978110B1 (en) * | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-based method and system for screening genomic DNA |
US20050239125A1 (en) * | 2000-09-06 | 2005-10-27 | Hodge Timothy A | Methods for genotype screening |
US20030207289A1 (en) * | 2001-09-04 | 2003-11-06 | Hodge Timothy A. | Detection of genetic sequences using a bipartite probe |
US20040185464A1 (en) * | 2000-09-15 | 2004-09-23 | Kris Richard M. | High throughput assay system |
DE10048944A1 (en) * | 2000-10-03 | 2002-04-18 | Andreas Kage | Process for the selection of nucleic acids that bind highly affine to a target by two-dimensional separation |
ATE380883T1 (en) * | 2000-10-24 | 2007-12-15 | Univ Leland Stanford Junior | DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA |
US20040018491A1 (en) * | 2000-10-26 | 2004-01-29 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
US20020142326A1 (en) * | 2000-11-30 | 2002-10-03 | Coull James M. | Methods and compositions for sorting and/or determining organisms |
US6858413B2 (en) * | 2000-12-13 | 2005-02-22 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
US6312929B1 (en) * | 2000-12-22 | 2001-11-06 | Cepheid | Compositions and methods enabling a totally internally controlled amplification reaction |
CA2433674A1 (en) * | 2001-01-05 | 2002-07-11 | Invitrogen Corporation | Method for relative quantification of attached nucleic acids |
FI115139B (en) * | 2001-01-10 | 2005-03-15 | Valtion Teknillinen | Method and test package for quantitative and / or comparative assessment of the variations of polynucleotide amounts in cell or tissue samples |
WO2002064743A2 (en) * | 2001-02-12 | 2002-08-22 | Rosetta Inpharmatics, Inc. | Confirming the exon content of rna transcripts by pcr using primers complementary to each respective exon |
WO2003012147A1 (en) * | 2001-02-20 | 2003-02-13 | Datascope Investment Corp. | Method for reusing standard blots and microarrays utilizing dna dendrimer technology |
BR0205268A (en) | 2001-03-09 | 2004-11-30 | Nugen Technologies Inc | Processes and compositions for mRNA sequence mplification |
EP1390537B1 (en) * | 2001-03-09 | 2013-11-13 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
US7029919B2 (en) * | 2001-05-04 | 2006-04-18 | Agilent Technologies, Inc. | Electro-optical device and methods for hybridization and detection |
US20030104421A1 (en) * | 2001-05-07 | 2003-06-05 | Colangelo Christopher M. | Methods and compositions for nucleic acid amplification |
AU2003303395A1 (en) * | 2001-05-22 | 2004-07-22 | Dahl, Gary, A. | Target-dependent transcription using deletion mutants of n4 rna polymerase |
GB0112868D0 (en) * | 2001-05-25 | 2001-07-18 | Secr Defence | Detection system |
DE10126630A1 (en) * | 2001-05-31 | 2003-01-09 | Peter Und Traudl Engelhorn Sti | Cell sorting method |
CA2450139A1 (en) * | 2001-06-11 | 2002-12-19 | Illumina, Inc | Multiplexed detection methods |
NZ530343A (en) * | 2001-06-22 | 2007-01-26 | Marshfield Clinic | Methods and oligonucleotides for the detection of E. coli 0157:H7 |
US20030170695A1 (en) * | 2001-06-29 | 2003-09-11 | Liang Shi | Enzymatic ligation-based identification of nucleotide sequences |
US20030082584A1 (en) * | 2001-06-29 | 2003-05-01 | Liang Shi | Enzymatic ligation-based identification of transcript expression |
US7473767B2 (en) * | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
EP1481076A4 (en) * | 2001-07-12 | 2005-05-11 | Illumina Inc | Multiplex nucleic acid reactions |
AU2002365115A1 (en) * | 2001-07-20 | 2003-09-02 | North Carolina State University | Light addressable electrochemical detection of duplex structures |
WO2003020983A1 (en) * | 2001-08-30 | 2003-03-13 | Virginia Commonwealth University | Allele specific pcr for genotyping |
US20060014186A1 (en) * | 2001-09-04 | 2006-01-19 | Hodge Timothy A | Methods for genotype screening of a strain disposed on an adsorbent carrier |
US7153656B2 (en) * | 2001-09-11 | 2006-12-26 | Los Alamos National Security, Llc | Nucleic acid sequence detection using multiplexed oligonucleotide PCR |
JP2005504275A (en) * | 2001-09-18 | 2005-02-10 | ユー.エス. ジェノミクス, インコーポレイテッド | Differential tagging of polymers for high-resolution linear analysis |
AU2002341891A1 (en) * | 2001-09-26 | 2003-04-07 | Epigenx Pharmaceuticals, Inc. | Assays for dna methylation changes |
US20070264641A1 (en) * | 2001-10-15 | 2007-11-15 | Li Alice X | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
JP3829690B2 (en) * | 2001-10-30 | 2006-10-04 | 株式会社日立製作所 | Nucleic acid sequence inspection method |
CA2471198A1 (en) * | 2001-12-20 | 2003-07-03 | Merck & Co., Inc. | Identification of novel polymorphic sites in the human mglur8 gene and uses thereof |
DE50213541D1 (en) * | 2002-01-11 | 2009-06-25 | Biospring Ges Fuer Biotechnolo | Process for the production of DNA |
DE60324253D1 (en) * | 2002-02-08 | 2008-12-04 | Olympus Corp | SPECIFIC MULTIPLEX ANALYSIS OF NUCLEIC ACIDS |
US7499806B2 (en) | 2002-02-14 | 2009-03-03 | Illumina, Inc. | Image processing in microsphere arrays |
JP4274948B2 (en) * | 2002-03-13 | 2009-06-10 | シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト | Nucleic acid detection method |
US7081339B2 (en) * | 2002-04-12 | 2006-07-25 | Primera Biosystems, Inc. | Methods for variation detection |
DE10220935B3 (en) * | 2002-05-10 | 2004-02-05 | Siemens Ag | Methods for the biochemical analysis of DNA and associated arrangement |
WO2003100099A1 (en) * | 2002-05-24 | 2003-12-04 | Cygene, Inc. | Parallel stranded duplexes of deoxyribonucleic acid and methods of use |
US7371520B2 (en) * | 2002-05-28 | 2008-05-13 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
DK1512015T3 (en) * | 2002-06-12 | 2009-07-06 | Genencor Int | Methods for improving the binding properties of a molecule |
FI20021325A0 (en) * | 2002-07-05 | 2002-07-05 | Valtion Teknillinen | Method and kit for determining the amount of individual polynucleotides |
US7192700B2 (en) * | 2002-12-20 | 2007-03-20 | Orchid Cellmark Inc. | Methods and compositions for conducting primer extension and polymorphism detection reactions |
CA2498713A1 (en) * | 2002-09-17 | 2004-04-01 | Richard Abraham Joseph | Real-time detection of nucleic acid reactions |
JP2006500033A (en) * | 2002-09-19 | 2006-01-05 | アプレラ コーポレイション | Methods and compositions for detecting targets |
US7153658B2 (en) * | 2002-09-19 | 2006-12-26 | Applera Corporation | Methods and compositions for detecting targets |
US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
GB0223563D0 (en) * | 2002-10-10 | 2002-11-20 | Secr Defence | Detection system |
AU2002342093A1 (en) * | 2002-10-23 | 2004-05-25 | Applera Corporation | Methods and composition for detecting targets |
US20040235005A1 (en) * | 2002-10-23 | 2004-11-25 | Ernest Friedlander | Methods and composition for detecting targets |
WO2004046343A2 (en) * | 2002-11-19 | 2004-06-03 | Applera Corporation | Polynucleotide sequence detection assays and analysis |
AU2003295745A1 (en) * | 2002-11-19 | 2004-06-15 | Applera Corporation | Polynucleotide sequence detection assays |
GB2395557A (en) * | 2002-11-22 | 2004-05-26 | Dynal Biotech Ltd | Nucleic acid probes |
EP3000899A1 (en) | 2002-12-04 | 2016-03-30 | Applied Biosystems, LLC | Multiplex amplification of polynucleotides |
ATE534748T1 (en) * | 2002-12-12 | 2011-12-15 | Nanosphere Inc | DIRECT SNP DETECTION USING NON-AMPLIFIED DNA |
US8206904B2 (en) | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
US7851150B2 (en) | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
EP1608952B1 (en) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay apparatus and method using microfluidic arrays |
US9487823B2 (en) * | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
CA2886504C (en) | 2002-12-20 | 2019-01-08 | Celera Corporation | Wdr12 polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
US20040180369A1 (en) * | 2003-01-16 | 2004-09-16 | North Carolina State University | Photothermal detection of nucleic acid hybridization |
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US8043834B2 (en) * | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
CA2521084A1 (en) | 2003-04-14 | 2004-10-28 | Nugen Technologies, Inc. | Global amplification using a randomly primed composite primer |
US20050009052A1 (en) * | 2003-04-22 | 2005-01-13 | Irm Llc, A Delaware Limited Liability Company | Differential tag length analysis of cell proliferation |
WO2004104172A2 (en) * | 2003-05-15 | 2004-12-02 | Bioarray Solutions, Ltd. | Hybridization-mediated analysis of polymorphisms |
DE10323685A1 (en) * | 2003-05-22 | 2004-12-09 | Rühe, Jürgen, Prof. Dr. | Process for the covalent immobilization of probe biomolecules on organic surfaces |
DE602004005711T2 (en) * | 2003-06-02 | 2007-12-27 | Check-Points Holding B.V. | FAST METHOD FOR THE DETECTION OF MICROORGANISMS IN FOOD SAMPLES |
WO2005001129A2 (en) * | 2003-06-06 | 2005-01-06 | Applera Corporation | Mobility cassettes |
US20070111204A1 (en) * | 2003-06-27 | 2007-05-17 | Kathleen Delgrosso | Methods for detecting nucleic acid variations |
DE602004019926D1 (en) * | 2003-06-30 | 2009-04-23 | Panasonic Corp | METHOD FOR MODIFYING A NUCLEOTIDE CHAIN |
US20100291637A1 (en) * | 2003-06-30 | 2010-11-18 | Panasonic Corporation | Method for modifying nucleotide chain |
CN1580283A (en) * | 2003-08-13 | 2005-02-16 | 清华大学 | Method for detecting nucleic acid molecule |
GB0319949D0 (en) * | 2003-08-26 | 2003-09-24 | Univ Strathclyde | Nucleic acid sequence identification |
US20050266417A1 (en) * | 2003-09-12 | 2005-12-01 | Francis Barany | Methods for identifying target nucleic acid molecules |
WO2005029705A2 (en) * | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
US20050089916A1 (en) * | 2003-10-28 | 2005-04-28 | Xiongwu Xia | Allele assignment and probe selection in multiplexed assays of polymorphic targets |
WO2005045060A2 (en) | 2003-10-29 | 2005-05-19 | Bioarray Solutions, Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded dna |
US20050191651A1 (en) * | 2003-10-30 | 2005-09-01 | North Carolina State University | Temperature-jump enhanced electrochemical detection of nucleic acid hybridization |
US20100000881A1 (en) * | 2003-10-30 | 2010-01-07 | North Carolina State University | Electrochemical detection of nucleic acid hybridization |
CA3050151C (en) | 2003-11-26 | 2023-03-07 | Celera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
US20050130213A1 (en) * | 2003-12-10 | 2005-06-16 | Tom Morrison | Selective ligation and amplification assay |
US7582430B2 (en) * | 2004-01-20 | 2009-09-01 | United States Of America As Represented By The Secretary Of The Army | Immunoliposome-nucleic acid amplification (ILNAA) assay |
EP1561823A1 (en) * | 2004-02-04 | 2005-08-10 | Biotez Berlin-Buch GmbH | Method for the detection of single nucleotid polymorphisms (SNP) of genes of drug metabolism and test system for performing such a method |
EP1715954A1 (en) | 2004-02-18 | 2006-11-02 | Applera Corporation | Multi-step bioassays on modular microfluidic application platforms |
AU2005220746A1 (en) * | 2004-03-05 | 2005-09-22 | Medical College Of Ohio | Methods and compositions for assessing nucleic acids and alleles |
ATE399884T1 (en) * | 2004-03-24 | 2008-07-15 | Applera Corp | CODING AND DECODING REACTIONS FOR DETERMINING TARGET POLYNUCLEOTIDES |
EP1745157A4 (en) * | 2004-04-12 | 2008-06-11 | Ohio Med College | Methods and compositions for assaying analytes |
US7364855B2 (en) * | 2004-04-30 | 2008-04-29 | Applera Corporation | Methods and kits for methylation detection |
EP1745154B1 (en) | 2004-05-07 | 2012-08-01 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof |
US7622281B2 (en) * | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
WO2005118871A1 (en) * | 2004-05-28 | 2005-12-15 | The Arizona Board Of Regents | Surface plasmon resonance sensor for detecting changes in polynucleotides mass |
US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
US7785843B2 (en) * | 2004-06-23 | 2010-08-31 | Sequenom, Inc. | Target-specific compomers and methods of use |
US7363170B2 (en) * | 2004-07-09 | 2008-04-22 | Bio Array Solutions Ltd. | Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products |
WO2006014869A1 (en) * | 2004-07-26 | 2006-02-09 | Parallele Bioscience, Inc. | Simultaneous analysis of multiple genomes |
DE102004037081A1 (en) * | 2004-07-30 | 2006-03-23 | Universität Bremen | Hybridization assay of nucleic acid, useful particularly for identifying nitrogen-fixing microorganisms, where the complex formed includes a lable in, or close to, the hybrid region |
DE112005001815A5 (en) * | 2004-07-30 | 2007-06-14 | Universität Bremen | Method for analyzing samples by means of hybridization |
EP1623996A1 (en) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved method of selecting a desired protein from a library |
US20060040258A1 (en) * | 2004-08-23 | 2006-02-23 | Huiyan Guo | Water-soluble conjugates and methods of preparation |
EP1791982B1 (en) | 2004-09-21 | 2011-01-05 | Life Technologies Corporation | TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (MIRNAs) |
ES2301268B1 (en) * | 2004-10-25 | 2009-05-01 | Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. | USE OF GEN SLUG, OR ITS REPLICATION, TRANSCRIPTION OR EXPRESSION PRODUCTS, IN THE IDENTIFICATION, DIAGNOSIS, PREVENTION OR TREATMENT OF CANCER DISSEMINATION AND / OR METASTASIS DEVELOPMENT. |
JPWO2006059769A1 (en) * | 2004-12-03 | 2008-06-05 | 愛知県 | Methods for diagnosis and prognosis of malignant lymphoma |
US20060134650A1 (en) * | 2004-12-21 | 2006-06-22 | Illumina, Inc. | Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis |
DE602005019324D1 (en) | 2004-12-29 | 2010-03-25 | Applied Biosystems Llc | MORE COMPLEMENTARY POLYNUCLEOTIDES |
US20060211024A1 (en) * | 2005-03-10 | 2006-09-21 | Gwc Technologies Incorporated | Methods for analysis of a nucleic acid sample |
WO2006099365A2 (en) | 2005-03-11 | 2006-09-21 | Applera Corporation | Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof |
US20060205090A1 (en) * | 2005-03-14 | 2006-09-14 | Newton Michael W | Water-soluble conjugates for electrochemical detection |
US20070026423A1 (en) * | 2005-03-16 | 2007-02-01 | Thomas Koehler | Method and test kit for the detection of target nucleic acids |
EP1863908B1 (en) * | 2005-04-01 | 2010-11-17 | Qiagen GmbH | Reverse transcription and amplification of rna with simultaneous degradation of dna |
US20060240442A1 (en) * | 2005-04-20 | 2006-10-26 | Vevea Dirk N | Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes |
US20060246463A1 (en) * | 2005-04-20 | 2006-11-02 | Vevea Dirk N | Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes |
US20070009925A1 (en) * | 2005-05-05 | 2007-01-11 | Applera Corporation | Genomic dna sequencing methods and kits |
AU2006341607B2 (en) * | 2005-05-31 | 2011-03-17 | Applied Biosystems, Llc. | Multiplexed amplification of short nucleic acids |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20060276220A1 (en) * | 2005-06-03 | 2006-12-07 | Judith Schure | Cell phone case with magnifier and method |
US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
US20070087360A1 (en) * | 2005-06-20 | 2007-04-19 | Boyd Victoria L | Methods and compositions for detecting nucleotides |
ATE490343T1 (en) * | 2005-06-30 | 2010-12-15 | Ge Healthcare Bio Sciences | DETECTION METHODS FOR GENE EXPRESSION |
US7977108B2 (en) * | 2005-07-25 | 2011-07-12 | Roche Molecular Systems, Inc. | Method for detecting a mutation in a repetitive nucleic acid sequence |
US20070065847A1 (en) * | 2005-08-11 | 2007-03-22 | Affymetrix, Inc. | Degeneratively Labeled Probes |
US20070111226A1 (en) | 2005-08-24 | 2007-05-17 | Applera Corporation | Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs |
WO2007030759A2 (en) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
EP1762627A1 (en) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Method for the activation of a nucleic acid for performing a polymerase reaction |
ATE389035T1 (en) * | 2005-09-13 | 2008-03-15 | Eppendorf Array Tech Sa | METHOD FOR DETECTING HOMOLOGOUS SEQUENCES THAT DIFFER BY A BASE ON A MICROARRAY |
US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
WO2007057652A1 (en) * | 2005-11-15 | 2007-05-24 | Solexa Limited | Method of target enrichment |
US7960105B2 (en) * | 2005-11-29 | 2011-06-14 | National Institutes Of Health | Method of DNA analysis using micro/nanochannel |
US20090104613A1 (en) * | 2005-12-23 | 2009-04-23 | Perkinelmer Las, Inc. | Methods and compositions relating to multiplexed genomic gain and loss assays |
AU2006331607B2 (en) * | 2005-12-23 | 2012-11-29 | Perkinelmer Health Sciences, Inc. | Comparative genomic hybridization on encoded multiplex particles |
US7932037B2 (en) * | 2007-12-05 | 2011-04-26 | Perkinelmer Health Sciences, Inc. | DNA assays using amplicon probes on encoded particles |
JP5537034B2 (en) | 2005-12-23 | 2014-07-02 | ナノストリング テクノロジーズ,インコーポレーテッド | Nanoreporter and method for producing and using the same |
US20100009373A1 (en) * | 2005-12-23 | 2010-01-14 | Perkinelmer Health Sciences, Inc. | Methods and compositions relating to multiplex genomic gain and loss assays |
EP1991700B1 (en) | 2006-02-13 | 2012-01-11 | The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services | Primers and probes for detection and discrimination of types and subtypes of influenza viruses |
US20070196832A1 (en) * | 2006-02-22 | 2007-08-23 | Efcavitch J William | Methods for mutation detection |
WO2007101075A2 (en) * | 2006-02-22 | 2007-09-07 | Applera Corporation | Double-ligation method for haplotype and large-scale polymorphism detection |
ES2446927T3 (en) * | 2006-03-01 | 2014-03-10 | Keygene N.V. | Rapid sequence-based SNP detection using ligation assays |
US8673567B2 (en) * | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
DE102006020885A1 (en) * | 2006-05-05 | 2007-11-08 | Qiagen Gmbh | Inserting a tag sequence into a nucleic acid comprises using an anchor oligonucleotide comprising a hybridizing anchor sequence and a nonhybridizing tag-template sequence |
US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
US20080044821A1 (en) * | 2006-08-21 | 2008-02-21 | Gafur Zainiev | Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes |
US20090286694A1 (en) * | 2006-08-21 | 2009-11-19 | Gafur Zainiev | Nucleic acid array with releaseable nucleic acid probes |
US20080044822A1 (en) * | 2006-08-21 | 2008-02-21 | Gafur Zainiev | Nucleic acid array with releaseable nucleic acid probes |
US20100056388A1 (en) * | 2006-08-21 | 2010-03-04 | Cnvgenes, Inc. | Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes |
US20080050724A1 (en) * | 2006-08-24 | 2008-02-28 | Microfluidic Systems, Inc. | Method of detecting one or more limited copy targets |
JP2008072950A (en) * | 2006-09-21 | 2008-04-03 | Sysmex Corp | Method for confirming conversion treatment and nucleic acid molecule used therefor |
EP2076609A1 (en) | 2006-10-10 | 2009-07-08 | Illumina Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
US20080090238A1 (en) * | 2006-10-12 | 2008-04-17 | Dan-Hui Dorothy Yang | Increased sensitivity of proximity ligation assays |
CA2915679C (en) | 2006-10-20 | 2017-12-12 | Celera Corporation | Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof |
US20090074637A1 (en) * | 2006-11-03 | 2009-03-19 | Murphy Michael C | Optimized Modular Microfluidic Devices |
US7902345B2 (en) * | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
US8133701B2 (en) * | 2006-12-05 | 2012-03-13 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
JP2008148570A (en) * | 2006-12-14 | 2008-07-03 | Hitachi Ltd | Microorganism detection system |
EP2121956B1 (en) | 2006-12-21 | 2016-08-17 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
CN101663323A (en) | 2006-12-27 | 2010-03-03 | 埃默里大学 | The composition and the method that are used for the treatment of transmissible disease and tumour |
US8930178B2 (en) | 2007-01-04 | 2015-01-06 | Children's Hospital Medical Center | Processing text with domain-specific spreading activation methods |
US20080182235A1 (en) * | 2007-01-30 | 2008-07-31 | Celsis International Plc | Detection of Analytes in Samples Using Liposome-Amplified Luminescence and Magnetic Separation |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
AU2008212117B2 (en) | 2007-02-07 | 2014-09-11 | Decode Genetics Ehf. | Genetic variants contributing to risk of prostate cancer |
US8906620B2 (en) | 2007-03-23 | 2014-12-09 | Dana-Farber Cancer Institute, Inc. | Exon grouping analysis |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
MX353428B (en) | 2007-05-21 | 2018-01-12 | Genentech Inc | Methods and compositions for identifying and treating lupus. |
WO2008146309A2 (en) | 2007-05-25 | 2008-12-04 | Decode Genetics Ehf. | Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
US20090036325A1 (en) * | 2007-05-25 | 2009-02-05 | Applera Corporation | Directed assembly of amplicons to enhance read pairing signature with massively parallel short read sequencers |
US7947446B2 (en) * | 2007-05-29 | 2011-05-24 | Ming-Sheng Lee | High throughput mutation screening methods and kits using a universalized approach—differential sequence fill-in (DSF)-enabled sequential adapter ligation and amplification |
EP2527472B1 (en) | 2007-05-31 | 2016-09-28 | Yale University | A genetic lesion associated with cancer |
CN101835900B (en) * | 2007-06-01 | 2015-04-15 | 莫诺匡特私人有限公司 | A method for DNA breakpoint analysis |
US20080305486A1 (en) * | 2007-06-06 | 2008-12-11 | Bio-Rad Laboratories, Inc. | Signal amplification using circular hairpin probes |
JP5165933B2 (en) * | 2007-06-12 | 2013-03-21 | 日本碍子株式会社 | Method and array for detecting specific partial sequence in target nucleic acid |
US8008010B1 (en) | 2007-06-27 | 2011-08-30 | Applied Biosystems, Llc | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor |
US9512470B2 (en) * | 2007-07-11 | 2016-12-06 | Pathofinder Holding B.V. | Method for the simultaneous detection of multiple nucleic acid sequences in a sample |
US9404150B2 (en) | 2007-08-29 | 2016-08-02 | Sequenom, Inc. | Methods and compositions for universal size-specific PCR |
WO2009036525A2 (en) * | 2007-09-21 | 2009-03-26 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
WO2009046445A1 (en) * | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
CA2702169A1 (en) * | 2007-10-12 | 2009-04-16 | Decode Genetics Ehf | Sequence variants for inferring human pigmentation patterns |
US8298768B2 (en) * | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
US10125388B2 (en) | 2007-10-31 | 2018-11-13 | Akonni Biosystems, Inc. | Integrated sample processing system |
US9428746B2 (en) | 2007-10-31 | 2016-08-30 | Akonni Biosystems, Inc. | Method and kit for purifying nucleic acids |
US20090111193A1 (en) | 2007-10-31 | 2009-04-30 | Cooney Christopher G | Sample preparation device |
US7759112B2 (en) * | 2007-10-31 | 2010-07-20 | Akonni Biosystems, Inc. | Apparatus, system, and method for purifying nucleic acids |
US8039212B2 (en) | 2007-11-05 | 2011-10-18 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
US8093063B2 (en) * | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
US8697360B2 (en) | 2007-11-30 | 2014-04-15 | Decode Genetics Ehf. | Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition |
US20090181390A1 (en) * | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
AU2009205523A1 (en) | 2008-01-14 | 2009-07-23 | Applied Biosystems, Llc | Compositions, methods, and kits for detecting ribonucleic acid |
US20090203531A1 (en) * | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
US8828657B2 (en) * | 2008-02-14 | 2014-09-09 | Decode Genetics Ehf. | Susceptibility variants for lung cancer |
US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
KR101419980B1 (en) * | 2008-03-15 | 2014-07-15 | 홀로직, 인크. | Compositions and methods for analysis of nucleic acid molecules during amplification reactions |
WO2009117698A2 (en) | 2008-03-21 | 2009-09-24 | Nugen Technologies, Inc. | Methods of rna amplification in the presence of dna |
JP5319148B2 (en) * | 2008-03-27 | 2013-10-16 | 日本碍子株式会社 | Method and array for detecting mutations in target nucleic acid |
NZ588905A (en) | 2008-04-01 | 2012-08-31 | Decode Genetics Ehf | Genetic testing method for determining susceptibility to abdominal aortic aneurysm by assay for selected polymorphisms associated with the disease |
CN107385040B (en) * | 2008-04-03 | 2022-02-15 | 艾瑞普特公司 | Amplicon rescue multiplex polymerase chain reaction for amplification of multiple targets |
US9335325B2 (en) * | 2008-04-19 | 2016-05-10 | New York University | Immunodominant Mycobacterium tuberculosis peptides from cell wall proteins for early diagnosis and immunization |
JP2009268665A (en) * | 2008-05-07 | 2009-11-19 | Canon Inc | Inhalation device |
BRPI0913578A2 (en) | 2008-05-14 | 2017-06-06 | Dermtech Int | diagnosis of melanoma and solar lentigo by nucleic acid analysis |
CN101586150B (en) * | 2008-05-23 | 2016-09-28 | 陕西佰美基因股份有限公司 | Detection probe, general oligonucleotide chip and nucleic acid detection method and application thereof |
CN102137938B (en) * | 2008-07-04 | 2015-01-21 | 解码遗传学私营有限责任公司 | Copy number variations predictive of risk of schizophrenia |
KR20110036608A (en) | 2008-07-07 | 2011-04-07 | 디코드 제네틱스 이에이치에프 | Genetic variants for breast cancer risk assessment |
EP2310525B1 (en) | 2008-07-09 | 2014-02-26 | Celera Corporation | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
WO2010012002A1 (en) * | 2008-07-25 | 2010-01-28 | Saryna Medical Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
CA2735250A1 (en) * | 2008-07-30 | 2010-02-04 | Nippon Steel Kankyo Engineering Co., Ltd. | Universal nucleic acid probe set and method for utilization thereof |
WO2010018600A1 (en) * | 2008-08-12 | 2010-02-18 | Decode Genetics Ehf | Genetic variants useful for risk assessment of thyroid cancer |
CA2734123A1 (en) * | 2008-08-15 | 2010-02-18 | Decode Genetics Ehf | Genetic variants predictive of cancer risk |
EP2326732A4 (en) * | 2008-08-26 | 2012-11-14 | Fluidigm Corp | Assay methods for increased throughput of samples and/or targets |
DK2370593T3 (en) | 2008-11-28 | 2016-07-04 | Univ Emory | A method for determining the effect of PD-1 Antagonists |
JP2012511927A (en) | 2008-12-17 | 2012-05-31 | ライフ テクノロジーズ コーポレーション | Methods, compositions, and kits for detecting allelic variants |
EP2384368B1 (en) | 2009-01-30 | 2016-01-27 | Kantonsspital Aarau AG | Gene dosage analysis |
US20120028254A1 (en) | 2009-02-06 | 2012-02-02 | Weidhaas Joanne B | SNP Marker of Breast and Ovarian Cancer Risk |
EP2399131B1 (en) | 2009-02-20 | 2014-08-27 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Method for the diagnosis of age-associated vascular disorders |
EP3249053A1 (en) | 2009-03-27 | 2017-11-29 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
US20120021949A1 (en) * | 2009-03-31 | 2012-01-26 | Centre Hospitalier Universitaire Vaudois | Methylation Ligation-Dependent Macroarray (MLM) |
WO2010114599A1 (en) * | 2009-04-01 | 2010-10-07 | Dx Terity Diagnostics Inc. | Chemical ligation dependent probe amplification (clpa) |
CN103952482A (en) | 2009-04-02 | 2014-07-30 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding of target nucleic acids |
AU2010231494B2 (en) | 2009-04-03 | 2016-01-07 | Decode Genetics Ehf | Genetic markers for risk management of atrial fibrillation and stroke |
EP2256215A1 (en) | 2009-04-30 | 2010-12-01 | Steffen Mergemeier | Assay system using a nuclease activity of a nucleic acid polymerase |
WO2010128530A1 (en) * | 2009-05-08 | 2010-11-11 | Decode Genetics Ehf | Genetic variants contributing to risk of prostate cancer |
US20110003301A1 (en) * | 2009-05-08 | 2011-01-06 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
US20100299773A1 (en) * | 2009-05-20 | 2010-11-25 | Monsanto Technology Llc | Methods and compositions for selecting an improved plant |
WO2010138908A1 (en) | 2009-05-29 | 2010-12-02 | Ventana Medical Systems, Inc. | Igfir gene copy number as a prognostic marker in a non-small cell lung cancer |
AU2010253978B2 (en) | 2009-05-29 | 2014-12-11 | Ventana Medical Systems, Inc. | Methods of scoring gene copy number in a biological sample using in situ hybridization |
WO2010138926A1 (en) | 2009-05-29 | 2010-12-02 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acids for detection and discrimination of genotypes of chlamydophila psittaci |
AU2010265889A1 (en) | 2009-06-25 | 2012-01-19 | Yale University | Single nucleotide polymorphisms in BRCA1 and cancer risk |
US9169512B2 (en) | 2009-07-01 | 2015-10-27 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
NZ598009A (en) | 2009-07-10 | 2013-11-29 | Decode Genetics Ehf | Genetic markers associated with risk of diabetes mellitus |
US9487839B2 (en) * | 2009-09-29 | 2016-11-08 | Case Western Reserve University | Method for detecting single nucleotide polymorphisms |
RU2016131167A (en) | 2009-10-07 | 2018-12-07 | Дженентек, Инк. | METHODS OF TREATMENT, DIAGNOSTICS AND MONITORING LUPUS |
EP2495334B1 (en) * | 2009-10-29 | 2018-04-18 | NGK Insulators, Ltd. | Method for detection of target nucleic acid |
SG10201407883PA (en) * | 2009-12-07 | 2015-01-29 | Illumina Inc | Multi-sample indexing for multiplex genotyping |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US9499814B2 (en) | 2010-01-22 | 2016-11-22 | The Regents Of The University Of California | Methods for identifying drug effects on a cell by determining changes in the cell's spliced message profile |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
DK2556171T3 (en) | 2010-04-05 | 2015-12-14 | Prognosys Biosciences Inc | Spatially CODED BIOLOGICAL ASSAYS |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
WO2011133474A2 (en) | 2010-04-18 | 2011-10-27 | Beth Israel Deaconess Medical Center | Methods of predicting predisposition to or risk of kidney disease |
US9260762B2 (en) | 2010-04-16 | 2016-02-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Real time PCR assay for detection of bacterial respiratory pathogens |
US20110269735A1 (en) | 2010-04-19 | 2011-11-03 | Celera Corporation | Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof |
WO2012006056A2 (en) | 2010-06-29 | 2012-01-12 | Oregon Health & Science University | Ccr6 as a biomarker of alzheimer's disease |
US8586301B2 (en) | 2010-06-30 | 2013-11-19 | Stratos Genomics, Inc. | Multiplexed identification of nucleic acid sequences |
WO2012018387A2 (en) | 2010-08-02 | 2012-02-09 | Population Diagnotics, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
CA2809643C (en) | 2010-08-30 | 2019-09-24 | John P. Davies | Sugarcane bacilliform viral (scbv) enhancer and its use in plant functional genomics |
AU2011296212B2 (en) | 2010-08-30 | 2015-06-11 | Dow Agrosciences Llc | Activation tagging platform for maize, and resultant tagged population and plants |
WO2012034013A2 (en) | 2010-09-10 | 2012-03-15 | Bio-Rad Laboratories, Inc. | Detection of rna-interacting regions in dna |
WO2012054933A2 (en) * | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
US20120108651A1 (en) | 2010-11-02 | 2012-05-03 | Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) | Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof |
US9228970B2 (en) | 2010-12-08 | 2016-01-05 | Imec | Heat-transfer resistance based analysis bioparticles |
US20130296175A1 (en) | 2011-01-13 | 2013-11-07 | Illumina Inc. | Genetic Variants as Markers for Use in Urinary Bladder Cancer Risk Assessment, Diagnosis, Prognosis and Treatment |
EP3567121B1 (en) | 2011-01-17 | 2023-08-30 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
EA201391074A1 (en) | 2011-01-25 | 2013-12-30 | Олмак Дайэгностикс Лимитед | PROFILES OF EXPRESSION OF GENES OF CANCER OF THICK INTEST. AND METHODS OF APPLICATION |
WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
US20120208193A1 (en) | 2011-02-15 | 2012-08-16 | Bio-Rad Laboratories, Inc. | Detecting methylation in a subpopulation of genomic dna |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
WO2012112883A1 (en) | 2011-02-18 | 2012-08-23 | Yale University | The kras-variant and endometriosis |
US20120219950A1 (en) | 2011-02-28 | 2012-08-30 | Arnold Oliphant | Assay systems for detection of aneuploidy and sex determination |
US20140065615A1 (en) | 2011-03-21 | 2014-03-06 | Yale University | The KRAS Variant and Tumor Biology |
US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
CA2850175C (en) | 2011-04-01 | 2021-04-13 | Genentech, Inc. | Biomarkers for predicting sensitivity to cancer treatments |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US10172305B2 (en) | 2011-04-29 | 2019-01-08 | Monsanto Technology Llc | Diagnostic molecular markers for seed lot purity traits in soybeans |
AU2012250879B2 (en) | 2011-05-02 | 2017-06-08 | Nutech Ventures | Plants with useful traits and related methods |
CN103649335B (en) | 2011-05-04 | 2015-11-25 | Htg分子诊断有限公司 | Quantitative nucleic acid enzyme protection measures the improvement of (QNPA) and order-checking (QNPS) |
WO2012154876A1 (en) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Probe based nucleic acid detection |
EP2710145B1 (en) * | 2011-05-17 | 2015-12-09 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
EP4249603A3 (en) | 2011-06-08 | 2024-01-03 | Life Technologies Corporation | Design and development of novel detergents for use in pcr systems |
WO2012170907A2 (en) | 2011-06-08 | 2012-12-13 | Life Technologies Corporation | Polymerization of nucleic acids using proteins having low isoelectric points |
US9040244B2 (en) | 2011-07-05 | 2015-05-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | HIV-1 genotyping assay for global surveillance of HIV-1 drug resistance |
EP2744916A4 (en) | 2011-07-13 | 2015-06-17 | Primeradx Inc | Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013012440A2 (en) * | 2011-07-21 | 2013-01-24 | Cornell University | Methods and devices for dna sequencing and molecular diagnostics |
WO2013033611A1 (en) | 2011-08-31 | 2013-03-07 | Monsanto Technology Llc | Methods and compositions for watermelon firmness |
US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
WO2013049613A1 (en) * | 2011-09-29 | 2013-04-04 | Luminex Corporation | Hydrolysis probes |
US20140234360A1 (en) | 2011-09-30 | 2014-08-21 | The United States of America, as represented by the Secretary, Dept.of Health and Human Services | Influenza vaccine |
US10221454B2 (en) | 2011-10-10 | 2019-03-05 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
GB2497838A (en) | 2011-10-19 | 2013-06-26 | Nugen Technologies Inc | Compositions and methods for directional nucleic acid amplification and sequencing |
WO2013067451A2 (en) | 2011-11-04 | 2013-05-10 | Population Diagnostics Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
CN105063186A (en) | 2011-11-10 | 2015-11-18 | 霍夫曼-拉罗奇有限公司 | Methods for treating, diagnosing and monitoring Alzheimer's disease |
US9890431B2 (en) | 2011-11-15 | 2018-02-13 | Université Libre de Bruxelles | Streptococcus pneumoniae detection in blood |
EP3483288B1 (en) | 2011-11-30 | 2022-03-16 | Children's Hospital Medical Center | Personalized pain management and anesthesia: preemptive risk identification |
CA2857114A1 (en) | 2011-11-30 | 2013-06-06 | Genentech, Inc. | Erbb3 mutations in cancer |
US10648030B2 (en) | 2012-01-13 | 2020-05-12 | Affymetrix, Inc. | Methods of determining the presence or absence of a plurality of target polynucleotides in a sample |
CN105861487B (en) | 2012-01-26 | 2020-05-05 | 纽亘技术公司 | Compositions and methods for targeted nucleic acid sequence enrichment and efficient library generation |
EP2812452B1 (en) | 2012-02-09 | 2020-05-27 | Population Bio, Inc. | Methods and compositions for screening and treating developmental disorders |
WO2013120089A1 (en) * | 2012-02-10 | 2013-08-15 | Raindance Technologies, Inc. | Molecular diagnostic screening assay |
WO2013122826A1 (en) * | 2012-02-14 | 2013-08-22 | Gnubio, Inc. | Cascaded addition of target specific universal adapters to nucleic acids |
JP6375230B2 (en) | 2012-02-27 | 2018-08-15 | セルラー リサーチ, インコーポレイテッド | Compositions and kits for molecular counting |
ES2776673T3 (en) | 2012-02-27 | 2020-07-31 | Univ North Carolina Chapel Hill | Methods and uses for molecular tags |
CA2865541C (en) * | 2012-02-27 | 2019-11-05 | Toray Industries, Inc. | Nucleic acid detection method |
US10077450B2 (en) | 2012-02-29 | 2018-09-18 | Dow Agrosciences Llc | Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics |
US9045803B2 (en) | 2012-02-29 | 2015-06-02 | Abbott Molecular Inc. | Hepatitis B virus typing and resistance assay |
US9428813B2 (en) | 2012-03-26 | 2016-08-30 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
US9803251B2 (en) | 2012-05-03 | 2017-10-31 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods of detecting influenza virus |
EP2852682B1 (en) | 2012-05-21 | 2017-10-04 | Fluidigm Corporation | Single-particle analysis of particle populations |
US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
MX2014014356A (en) | 2012-05-24 | 2015-07-06 | Fundació Inst D Investigació Biomédica De Bellvitge Idibell | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis. |
US9394574B2 (en) | 2012-06-12 | 2016-07-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for detecting Legionella nucleic acids in a sample |
WO2013188839A1 (en) | 2012-06-14 | 2013-12-19 | Life Technologies Corporation | Novel compositions, methods and kits for real time polymerase chain reaction (pcr) |
CN104619894B (en) | 2012-06-18 | 2017-06-06 | 纽亘技术公司 | For the composition and method of the Solid phase of unexpected nucleotide sequence |
WO2013192292A1 (en) | 2012-06-21 | 2013-12-27 | Justin Lamb | Massively-parallel multiplex locus-specific nucleic acid sequence analysis |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
CN104583421A (en) | 2012-07-19 | 2015-04-29 | 阿瑞奥萨诊断公司 | Multiplexed sequential ligation-based detection of genetic variants |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9976180B2 (en) | 2012-09-14 | 2018-05-22 | Population Bio, Inc. | Methods for detecting a genetic variation in subjects with parkinsonism |
CA2922005A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
CA2886605A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
EP3260558B1 (en) | 2012-11-02 | 2020-05-13 | Life Technologies Corporation | Novel compositions and methods for enhancing pcr specificity |
WO2014074942A1 (en) | 2012-11-08 | 2014-05-15 | Illumina, Inc. | Risk variants of alzheimer's disease |
US10314253B2 (en) | 2012-12-04 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and compositions for watermelon sex expression |
WO2014089536A1 (en) * | 2012-12-07 | 2014-06-12 | Invitae Corporation | Multiplex nucleic acid detection methods |
CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
AU2014205110A1 (en) * | 2013-01-13 | 2015-08-27 | Unitaq Bio | Methods and compositions for PCR using blocked and universal primers |
EP3862435A1 (en) | 2013-02-08 | 2021-08-11 | 10X Genomics, Inc. | Polynucleotide barcode generation |
JP6669500B2 (en) | 2013-02-25 | 2020-03-18 | ジェネンテック, インコーポレイテッド | Methods and compositions for detecting and treating drug resistant AKT variants |
US9982255B2 (en) * | 2013-03-11 | 2018-05-29 | Kailos Genetics, Inc. | Capture methodologies for circulating cell free DNA |
EP3640347A3 (en) | 2013-03-12 | 2020-07-29 | Life Technologies Corporation | Universal reporter-based genotyping methods and materials |
US20140272959A1 (en) * | 2013-03-14 | 2014-09-18 | President And Fellows Of Harvard College | Methods of Hybridizing Probes to Genomic DNA |
WO2014152155A1 (en) | 2013-03-14 | 2014-09-25 | The Broad Institute, Inc. | Massively multiplexed rna sequencing |
GB2584364A (en) | 2013-03-15 | 2020-12-02 | Abvitro Llc | Single cell bar-coding for antibody discovery |
US10294489B2 (en) | 2013-03-15 | 2019-05-21 | Board Of Trustees Of Southern Illinois University | Soybean resistant to cyst nematodes |
SG11201507272RA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nuclei acid amplification |
SG11201507261WA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nucleic acid amplification |
EP2971130A4 (en) | 2013-03-15 | 2016-10-05 | Nugen Technologies Inc | Sequential sequencing |
US9416387B2 (en) | 2013-03-15 | 2016-08-16 | Theranos, Inc. | Nucleic acid amplification |
US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
US9822418B2 (en) | 2013-04-22 | 2017-11-21 | Icahn School Of Medicine At Mount Sinai | Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis |
US10059999B2 (en) | 2013-06-10 | 2018-08-28 | Monsanto Technology Llc | Molecular markers associated with soybean tolerance to low iron growth conditions |
AU2014278730B2 (en) | 2013-06-13 | 2020-12-10 | F. Hoffmann-La Roche Ag | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
CN111662960B (en) | 2013-06-25 | 2024-04-12 | 普罗格诺西斯生物科学公司 | Spatially encoded bioanalytical analysis using microfluidic devices |
EP3726213A1 (en) * | 2013-08-19 | 2020-10-21 | Singular Bio Inc. | Assays for single molecule detection and use thereof |
KR20230074639A (en) | 2013-08-28 | 2023-05-30 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
US20150132743A1 (en) | 2013-09-04 | 2015-05-14 | Fluidigm Corporation | Proximity assays for detecting nucleic acids and proteins in a single cell |
US10767188B2 (en) | 2013-09-25 | 2020-09-08 | Nutech Ventures | Methods and compositions for obtaining useful plant traits |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9582877B2 (en) | 2013-10-07 | 2017-02-28 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
US10006097B2 (en) | 2013-10-22 | 2018-06-26 | The United States of America, as represented by the Secretry, Department of Health and Human Services | Compositions and methods for detection and discrimination of influenza viruses |
CN106458885B (en) | 2013-10-25 | 2019-12-10 | 生命技术公司 | Novel compounds for use in polymerase chain reaction systems and uses thereof |
DK2891722T3 (en) | 2013-11-12 | 2019-01-07 | Population Bio Inc | METHODS AND COMPOSITIONS FOR DIAGNOSTICING, PROGRAMMING AND TREATMENT OF ENDOMETRIOSIS |
US10364465B2 (en) | 2013-11-12 | 2019-07-30 | Life Technologies Corporation | Reagents and methods for sequencing |
WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
US20160273027A1 (en) * | 2013-11-26 | 2016-09-22 | Bio-Rad Laboratories, Inc. | Methods for detecting nucleic acids proximity |
NZ728726A (en) | 2013-11-27 | 2018-09-28 | Seminis Vegetable Seeds Inc | Disease resistance loci in onion |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US9824068B2 (en) | 2013-12-16 | 2017-11-21 | 10X Genomics, Inc. | Methods and apparatus for sorting data |
EP2986742A4 (en) * | 2014-01-10 | 2016-12-07 | Bio Rad Laboratories Inc | Intercalating dyes for differential detection |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
CN106231893B (en) | 2014-02-21 | 2019-10-18 | 先正达参股股份有限公司 | Genetic loci relevant to the increased fertilizability of corn |
EP3107930A1 (en) | 2014-02-21 | 2016-12-28 | THE UNITED STATES OF AMERICA, represented by the S | Hiv-2 nucleic acids and methods of detection |
JP6581117B2 (en) | 2014-02-24 | 2019-09-25 | チルドレンズ ホスピタル メディカル センター | Methods and compositions for personalized pain management |
NZ630710A (en) | 2014-02-27 | 2016-03-31 | Seminis Vegetable Seeds Inc | Compositions and methods for peronospora resistance in spinach |
WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
WO2015147370A1 (en) * | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
ES2807222T3 (en) | 2014-04-01 | 2021-02-22 | Univ Cornell | Detection of DNA methylation using combined ligation and nuclease reactions |
EP3125907A4 (en) | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
EP3792366A1 (en) * | 2014-04-04 | 2021-03-17 | Affymetrix, Inc. | Improved compositions and methods for molecular inversion probe assays |
AU2015243445B2 (en) | 2014-04-10 | 2020-05-28 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
US20170044631A1 (en) | 2014-04-14 | 2017-02-16 | The Unite States of America, as represented by the Secretary, Dept. of Health and Human Services | Methods for rapid detection and identification of viral nucleic acids |
WO2015179706A1 (en) | 2014-05-23 | 2015-11-26 | Fluidigm Corporation | Haploidome determination by digitized transposons |
EP3152331B1 (en) * | 2014-06-06 | 2019-08-07 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
WO2015199976A1 (en) | 2014-06-24 | 2015-12-30 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Target activated microdissection |
CN106795553B (en) | 2014-06-26 | 2021-06-04 | 10X基因组学有限公司 | Methods of analyzing nucleic acids from individual cells or cell populations |
US10316369B2 (en) | 2014-06-27 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and assays for male sterile watermelon |
EP3175001B1 (en) | 2014-07-30 | 2021-02-10 | Mor Research Applications Ltd. | Prognostic methods and systems of treatment for acute lymphoblastic leukemia |
GB201413718D0 (en) * | 2014-08-01 | 2014-09-17 | Olink Ab | Method for selecting a target nucleic acid sequence |
EP3177738B1 (en) | 2014-08-08 | 2019-10-09 | Children's Hospital Medical Center | Diagnostic method for distinguishing forms of esophageal eosinophilia |
CN108064315B (en) | 2014-08-22 | 2022-01-18 | 西菲伊德公司 | Method for detecting influenza |
US10724096B2 (en) | 2014-09-05 | 2020-07-28 | Population Bio, Inc. | Methods and compositions for inhibiting and treating neurological conditions |
US10683534B2 (en) | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
US9856521B2 (en) | 2015-01-27 | 2018-01-02 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
US11091810B2 (en) | 2015-01-27 | 2021-08-17 | BioSpyder Technologies, Inc. | Focal gene expression profiling of stained FFPE tissues with spatial correlation to morphology |
SG11201702060VA (en) | 2014-09-15 | 2017-04-27 | Abvitro Inc | High-throughput nucleotide library sequencing |
CN113736863A (en) * | 2014-09-17 | 2021-12-03 | 赛拉诺斯知识产权有限责任公司 | Diagnostic methods and compositions |
EP3005862A1 (en) | 2014-10-10 | 2016-04-13 | Seminis Vegetable Seeds, Inc. | Melon plants with improved disease tolerance |
EP3207156A1 (en) | 2014-10-13 | 2017-08-23 | Life Technologies Corporation | Methods, kits & compositions for determining gene copy numbers |
WO2016069853A2 (en) | 2014-10-30 | 2016-05-06 | Cepheid | Methods of detecting ebola |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
EP3216866B1 (en) * | 2014-11-06 | 2021-04-14 | Osaka City University | Clamping probe |
WO2016089920A1 (en) | 2014-12-01 | 2016-06-09 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
US10085951B2 (en) | 2014-12-11 | 2018-10-02 | Designs For Health, Inc. | Curcuminoid formulations and related methods of treatment |
ES2764975T3 (en) | 2014-12-15 | 2020-06-05 | Cepheid | Nucleic acid amplification on exponential basis greater than 2 |
EP3241900B1 (en) * | 2014-12-19 | 2020-07-08 | Eiken Kagaku Kabushiki Kaisha | Oligonucleotide probe for detecting single nucleotide polymorphism, and method for detecting single nucleotide polymorphism |
KR101728023B1 (en) * | 2015-01-02 | 2017-04-18 | 주식회사 랩 지노믹스 | Detection of mutations in ATP7B gene using PCR-LDR |
EP3244992B1 (en) | 2015-01-12 | 2023-03-08 | 10X Genomics, Inc. | Processes for barcoding nucleic acids |
US9984201B2 (en) | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
CN107208160B (en) * | 2015-01-30 | 2023-02-17 | 哈佛学院院长及董事 | No microscope imaging |
EP3259371B1 (en) | 2015-02-19 | 2020-09-02 | Becton, Dickinson and Company | High-throughput single-cell analysis combining proteomic and genomic information |
EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
US20160246813A1 (en) * | 2015-02-25 | 2016-08-25 | International Business Machines Corporation | System and method for machine information life cycle |
WO2016138490A1 (en) | 2015-02-27 | 2016-09-01 | Fluidigm Corporation | Single-cell nucleic acids for high-throughput studies |
WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
CN107614700A (en) | 2015-03-11 | 2018-01-19 | 布罗德研究所有限公司 | Genotype and phenotype coupling |
US9434996B1 (en) | 2015-03-13 | 2016-09-06 | Tracy Ann Hayden | All mini-STR multiplex with increased C.E. through-put by STR prolongation template fusion |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
US20160299129A1 (en) * | 2015-04-07 | 2016-10-13 | Xiaolei Qiu | Ultra Sensitive and Specific Multiplex Biosensor System Based on Multiple Cooperative Interactions |
DK3901281T3 (en) | 2015-04-10 | 2023-01-23 | Spatial Transcriptomics Ab | SPATIALLY SEPARATE, MULTIPLEX NUCLEIC ACID ANALYSIS OF BIOLOGICAL SAMPLES |
CN107532213B (en) * | 2015-04-23 | 2021-05-11 | 病理取景器控股有限责任公司 | Method for simultaneously detecting multiple nucleic acid sequences in a sample |
CN107580632B (en) * | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | Methods and compositions for whole transcriptome amplification |
BR112017023275B1 (en) | 2015-04-28 | 2023-11-21 | Monsanto Technology Llc | METHODS FOR SELECTING A BRACHITICA CORN PLANT OR SEED |
UA126326C2 (en) | 2015-04-30 | 2022-09-21 | Монсанто Текнолоджі Елелсі | Methods for producing canola plants with clubroot resistance and compositions thereof |
WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
CN107922941A (en) | 2015-06-15 | 2018-04-17 | 塞弗德公司 | The purifying and measurement and mutation and/or the common measurement of mRNA expressions of the integration of DNA methylation in reaction box is automated |
EP3608420B1 (en) | 2015-07-29 | 2021-05-19 | Progenity, Inc. | Nucleic acids and methods for detecting chromosomal abnormalities |
WO2017031370A1 (en) | 2015-08-18 | 2017-02-23 | The Broad Institute, Inc. | Methods and compositions for altering function and structure of chromatin loops and/or domains |
WO2017031059A1 (en) | 2015-08-18 | 2017-02-23 | Monsanto Technology Llc | Methods for producing cotton plants with enhanced drought tolerance and compositions thereof |
US10448595B2 (en) | 2015-09-03 | 2019-10-22 | Seminis Vegetable Seeds, Inc. | Downy mildew resistant lettuce plants |
US11118216B2 (en) | 2015-09-08 | 2021-09-14 | Affymetrix, Inc. | Nucleic acid analysis by joining barcoded polynucleotide probes |
US10858709B2 (en) | 2015-09-10 | 2020-12-08 | Monsanto Technology Llc | Methods for producing corn plants with downy mildew resistance and compositions thereof |
JP6940484B2 (en) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | Methods and compositions for library normalization |
WO2017053903A1 (en) | 2015-09-24 | 2017-03-30 | Abvitro Llc | Single amplicon activated exclusion pcr |
CN108291257B (en) | 2015-09-24 | 2023-12-29 | 阿布维特罗有限责任公司 | Affinity oligonucleotides conjugate and use thereof |
CN108369230B (en) | 2015-09-25 | 2021-09-17 | 阿布维特罗有限责任公司 | High throughput method for T cell receptor targeted identification of naturally paired T cell receptor sequences |
EP3371211A4 (en) | 2015-11-04 | 2019-08-21 | Icahn School of Medicine at Mount Sinai | Methods of treating tumors and cancer, and identifying candidate subjects for such treatment |
WO2017087560A1 (en) | 2015-11-16 | 2017-05-26 | Progenity, Inc. | Nucleic acids and methods for detecting methylation status |
CN108350499B (en) * | 2015-11-19 | 2022-05-13 | 10X基因组学有限公司 | Convertible marking compositions, methods, and processes incorporating same |
US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
JP6703824B2 (en) * | 2015-11-30 | 2020-06-03 | シスメックス株式会社 | Cell selection method, cell detection method, cell selection device, and cell detection device |
SG10202108763UA (en) | 2015-12-04 | 2021-09-29 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
EP3390658B1 (en) | 2015-12-16 | 2022-08-03 | Standard BioTools Inc. | High-level multiplex amplification |
US10694693B2 (en) | 2015-12-18 | 2020-06-30 | Monsanto Technology Llc | Methods for producing corn plants with northern leaf blight resistance and compositions thereof |
US10894985B2 (en) | 2016-01-12 | 2021-01-19 | Sitokine Limited | Methods for predicting response to treatment |
US10821094B2 (en) | 2016-01-13 | 2020-11-03 | Children's Hospital Medical Center | Compositions and methods for treating allergic inflammatory conditions |
SG11201806757XA (en) | 2016-02-11 | 2018-09-27 | 10X Genomics Inc | Systems, methods, and media for de novo assembly of whole genome sequence data |
US11246868B2 (en) | 2016-04-26 | 2022-02-15 | Icahn School Of Medicine At Mount Sinai | Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment |
CN109790581A (en) | 2016-04-27 | 2019-05-21 | 米拉迪克斯有限公司 | KRAS- variant cancer patient based on immune treatment |
JP7129343B2 (en) | 2016-05-02 | 2022-09-01 | ベクトン・ディキンソン・アンド・カンパニー | Accurate molecular barcoding |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
CN109074430B (en) | 2016-05-26 | 2022-03-29 | 贝克顿迪金森公司 | Molecular marker counting adjustment method |
US10202650B2 (en) | 2016-05-31 | 2019-02-12 | Youhealth Biotech, Limited | Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
EP3472349A1 (en) | 2016-06-16 | 2019-04-24 | Life Technologies Corporation | Novel compositions, methods and kits for microorganism detection |
WO2018005284A1 (en) | 2016-06-27 | 2018-01-04 | The United State Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for influenza a virus subtyping |
CN107847515B (en) | 2016-07-06 | 2021-01-29 | 优美佳生物技术有限公司 | Solid tumor methylation marker and application thereof |
WO2018009703A1 (en) | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Breast and ovarian cancer methylation markers and uses thereof |
US10093986B2 (en) | 2016-07-06 | 2018-10-09 | Youhealth Biotech, Limited | Leukemia methylation markers and uses thereof |
US10822648B1 (en) | 2016-07-29 | 2020-11-03 | Labrador Diagnostics Llc | Hybrid multi-step nucleic acid amplification |
WO2018031874A1 (en) | 2016-08-11 | 2018-02-15 | Monsanto Technology Llc | Methods and compositions for producing corn plants with resistance to late wilt |
CN109689886A (en) | 2016-08-26 | 2019-04-26 | 生命技术公司 | Nucleic acid extraction and amplification control and its application method |
WO2018057502A2 (en) | 2016-09-20 | 2018-03-29 | President And Fellows Harvard College | Molecular verification systems |
BR112019005748A2 (en) | 2016-09-24 | 2019-06-18 | Abvitro Llc | affinity-conjugates of oligonucleotides and uses of these |
KR102363716B1 (en) | 2016-09-26 | 2022-02-18 | 셀룰러 리서치, 인크. | Determination of protein expression using reagents having barcoded oligonucleotide sequences |
AU2017232187B2 (en) | 2016-09-30 | 2023-11-09 | Seminis Vegetable Seeds, Inc. | Xanthomonas resistant brassica oleracea plants |
US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
US11447530B2 (en) | 2016-12-06 | 2022-09-20 | Oregon State University | Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus |
EP3551332B1 (en) | 2016-12-12 | 2024-01-10 | Cepheid | Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge |
JP2020503857A (en) | 2016-12-12 | 2020-02-06 | セファイド | Integrated immuno-PCR and nucleic acid analysis in automated reaction cartridges |
WO2018118808A1 (en) | 2016-12-19 | 2018-06-28 | The Broad Institute, Inc. | Methods of treating autism spectrum disorders |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
ES2961580T3 (en) | 2017-01-13 | 2024-03-12 | Cellular Res Inc | Hydrophilic coating of fluid channels |
EP3571309A4 (en) | 2017-01-20 | 2020-11-25 | Children's Hospital Medical Center | Methods and compositions relating to oprm1 dna methylation for personalized pain management |
WO2018140966A1 (en) | 2017-01-30 | 2018-08-02 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
US10513739B2 (en) | 2017-03-02 | 2019-12-24 | Youhealth Oncotech, Limited | Methylation markers for diagnosing hepatocellular carcinoma and lung cancer |
CN110446787A (en) | 2017-03-24 | 2019-11-12 | 生物辐射实验室股份有限公司 | General clamp primers |
CN110536969A (en) | 2017-04-24 | 2019-12-03 | 豪夫迈·罗氏有限公司 | ERBB2/HER2 mutation in cross-film or nearly film domain |
US11708613B2 (en) | 2017-05-03 | 2023-07-25 | The United States of America, as Represened by the Secretary, Department of Health and Human Services | Rapid detection of Zika virus by reverse transcription loop-mediated isothermal amplification |
WO2018213803A1 (en) | 2017-05-19 | 2018-11-22 | Neon Therapeutics, Inc. | Immunogenic neoantigen identification |
US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
CN111148849A (en) | 2017-05-26 | 2020-05-12 | 阿布维托有限责任公司 | High throughput polynucleotide library sequencing and transcriptome analysis |
SG11201901822QA (en) | 2017-05-26 | 2019-03-28 | 10X Genomics Inc | Single cell analysis of transposase accessible chromatin |
EP4345172A2 (en) | 2017-06-05 | 2024-04-03 | Becton, Dickinson and Company | Sample indexing for single cells |
WO2018232028A1 (en) | 2017-06-14 | 2018-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Detection of blaimp antibacterial resistance genes |
WO2019051335A1 (en) | 2017-09-07 | 2019-03-14 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
WO2019055829A1 (en) | 2017-09-15 | 2019-03-21 | Nazarian Javad | Methods for detecting cancer biomarkers |
EP4339298A3 (en) | 2017-09-25 | 2024-04-17 | Fred Hutchinson Cancer Center | High efficiency targeted in situ genome-wide profiling |
US10837047B2 (en) | 2017-10-04 | 2020-11-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
US20200255828A1 (en) | 2017-10-04 | 2020-08-13 | The Broad Institute, Inc. | Methods and compositions for altering function and structure of chromatin loops and/or domains |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
WO2019084043A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | Methods and systems for nuclecic acid preparation and chromatin analysis |
EP3700672B1 (en) | 2017-10-27 | 2022-12-28 | 10X Genomics, Inc. | Methods for sample preparation and analysis |
US20200340041A1 (en) | 2017-11-13 | 2020-10-29 | Life Technologies Corporation | Novel compositions, methods and kits for urinary tract microorganism detection |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
WO2019108851A1 (en) | 2017-11-30 | 2019-06-06 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation and analysis |
WO2019126209A1 (en) | 2017-12-19 | 2019-06-27 | Cellular Research, Inc. | Particles associated with oligonucleotides |
WO2019133727A1 (en) | 2017-12-29 | 2019-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Universal influenza virus probe set for enrichment of any influenza virus nucleic acid |
WO2019152860A1 (en) | 2018-02-02 | 2019-08-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Random amplification methods for extremely low input nucleic acids |
WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
US11859250B1 (en) | 2018-02-23 | 2024-01-02 | Children's Hospital Medical Center | Methods for treating eosinophilic esophagitis |
CN112166199A (en) | 2018-04-02 | 2021-01-01 | 普罗格尼迪公司 | Methods, systems, and compositions for counting nucleic acid molecules |
SG11202009889VA (en) | 2018-04-06 | 2020-11-27 | 10X Genomics Inc | Systems and methods for quality control in single cell processing |
CA3096508A1 (en) * | 2018-04-20 | 2019-10-24 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the detection of microbial resistance |
CN112272710A (en) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | High throughput omics sample analysis |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
WO2019213619A1 (en) | 2018-05-04 | 2019-11-07 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
CN108531599A (en) * | 2018-05-08 | 2018-09-14 | 杭州泰领生物技术有限公司 | A kind of kit and method of people HLA-B*5801 genotype |
US11268102B2 (en) | 2018-05-16 | 2022-03-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for identifying and selecting brachytic locus in solanaceae |
US11932899B2 (en) | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
US11703427B2 (en) | 2018-06-25 | 2023-07-18 | 10X Genomics, Inc. | Methods and systems for cell and bead processing |
EP3829569A4 (en) | 2018-07-27 | 2022-04-27 | Aperta Biosciences, LLC | Spinosyn formulations for treatment of demodex-induced ocular and facial conditions |
US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
EP4177356A1 (en) | 2018-08-08 | 2023-05-10 | PML Screening, LLC | Methods for assessing risk of developing a viral disease using a genetic test |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
EP3861134A1 (en) | 2018-10-01 | 2021-08-11 | Becton, Dickinson and Company | Determining 5' transcript sequences |
EP3874064A1 (en) | 2018-10-29 | 2021-09-08 | Cepheid | Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
WO2020123320A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Imaging system hardware |
US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
CA3126761C (en) | 2019-01-15 | 2023-01-10 | Seminis Vegetable Seeds, Inc. | Green bean plants with improved disease resistance |
WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
EP3914728B1 (en) | 2019-01-23 | 2023-04-05 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
SG11202108788TA (en) | 2019-02-12 | 2021-09-29 | 10X Genomics Inc | Methods for processing nucleic acid molecules |
US11467153B2 (en) | 2019-02-12 | 2022-10-11 | 10X Genomics, Inc. | Methods for processing nucleic acid molecules |
US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
US11655499B1 (en) | 2019-02-25 | 2023-05-23 | 10X Genomics, Inc. | Detection of sequence elements in nucleic acid molecules |
WO2020185791A1 (en) | 2019-03-11 | 2020-09-17 | 10X Genomics, Inc. | Systems and methods for processing optically tagged beads |
CA3134936A1 (en) | 2019-03-26 | 2020-10-01 | Dermtech, Inc. | Novel gene classifiers and uses thereof in skin cancers |
WO2020206170A1 (en) | 2019-04-02 | 2020-10-08 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
US11965208B2 (en) | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
US20220249660A1 (en) | 2019-06-06 | 2022-08-11 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
WO2021016239A1 (en) | 2019-07-22 | 2021-01-28 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
SG10202008262UA (en) | 2019-09-26 | 2021-04-29 | Seminis Vegetable Seeds Inc | Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1 |
US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
WO2021089643A1 (en) | 2019-11-04 | 2021-05-14 | Mirnax Biosens, S.L. | Bivalent reverse primer |
EP3901286A1 (en) | 2020-04-24 | 2021-10-27 | Mirnax Biosens, S.L. | Bivalent reverse primer |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
CN114729350A (en) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | Obtaining full-length V (D) J information for immunohistorian sequencing using random priming |
EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
ES2946357T3 (en) | 2019-12-23 | 2023-07-17 | 10X Genomics Inc | Methods for spatial analysis using RNA template ligation |
WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
EP4242325A3 (en) | 2020-04-22 | 2023-10-04 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
US11851700B1 (en) | 2020-05-13 | 2023-12-26 | 10X Genomics, Inc. | Methods, kits, and compositions for processing extracellular molecules |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
EP4025692A2 (en) | 2020-06-02 | 2022-07-13 | 10X Genomics, Inc. | Nucleic acid library methods |
EP4158054A1 (en) | 2020-06-02 | 2023-04-05 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
EP4165207A1 (en) | 2020-06-10 | 2023-04-19 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
WO2021263111A1 (en) | 2020-06-25 | 2021-12-30 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
US20220017979A1 (en) | 2020-06-26 | 2022-01-20 | Cepheid | Methods of detecting sars-cov-2, influenza, and rsv |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
AU2021204717A1 (en) | 2020-07-15 | 2022-02-03 | Seminis Vegetable Seeds, Inc. | Green Bean Plants with Improved Disease Resistance |
KR20230056685A (en) | 2020-07-23 | 2023-04-27 | 라이프 테크놀로지스 코포레이션 | Compositions, systems and methods for biological assays using dyes |
US20240060117A1 (en) | 2020-07-23 | 2024-02-22 | Life Technologies Corporation | Energy transfer dye conjugates for use in biological assays |
WO2022056078A1 (en) | 2020-09-11 | 2022-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Rnase h-assisted detection assay for rna (radar) |
AU2021345359A1 (en) | 2020-09-21 | 2023-05-11 | Progenity, Inc. | Compositions and methods for isolation of cell-free dna |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
BR112023006262A2 (en) | 2020-10-06 | 2023-05-09 | Cepheid | METHODS FOR TUBERCULOSIS DIAGNOSIS AND DIFFERENTIATION BETWEEN ACTIVE AND LATENT TUBERCULOSIS |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
AU2022227563A1 (en) | 2021-02-23 | 2023-08-24 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
AU2022238446A1 (en) | 2021-03-18 | 2023-09-07 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
CN116635538A (en) | 2021-10-22 | 2023-08-22 | 塞弗德公司 | Compositions and methods for diagnosing and treating tuberculosis |
US20230193310A1 (en) | 2021-12-10 | 2023-06-22 | Seminis Vegetabe Seeds, Inc. | Lettuce plants having resistance to downy mildew |
US20240035016A1 (en) | 2022-04-29 | 2024-02-01 | Cepheid | Nucleic acid extraction and isolation with heat labile silanes and chemically modified solid supports |
US20240017255A1 (en) | 2022-05-19 | 2024-01-18 | Cepheid | Mvp cartridge and methods of use and manufacture |
WO2023250288A2 (en) | 2022-06-21 | 2023-12-28 | Seminis Vegetable Seeds, Inc. | Novel qtls conferring resistance to cucumber mosaic virus |
WO2024059692A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
WO1993017126A1 (en) * | 1992-02-19 | 1993-09-02 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5407798A (en) * | 1990-10-16 | 1995-04-18 | Ciba Corning Diagnostics Corp. | Amplification of midivariant DNA templates |
US5536649A (en) * | 1993-05-11 | 1996-07-16 | Becton, Dickinson And Company | Decontamination of nucleic acid amplification reactions using uracil-N-glycosylase (UDG) |
US5593840A (en) * | 1993-01-27 | 1997-01-14 | Oncor, Inc. | Amplification of nucleic acid sequences |
Family Cites Families (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258506A (en) * | 1984-10-16 | 1993-11-02 | Chiron Corporation | Photolabile reagents for incorporation into oligonucleotide chains |
US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4925785A (en) * | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
AU624601B2 (en) | 1988-01-21 | 1992-06-18 | Genentech Inc. | Amplification and detection of nucleic acid sequences |
GB8810400D0 (en) * | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5185243A (en) * | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
AU629845B2 (en) | 1988-08-30 | 1992-10-15 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
ATE157404T1 (en) | 1989-03-17 | 1997-09-15 | Abbott Lab | METHOD AND DEVICE FOR HYBRIDIZING NUCLEIC ACID WITH IMPROVED REACTION KINETICS |
WO1990011372A1 (en) | 1989-03-21 | 1990-10-04 | Collaborative Research, Inc. | Multiplex dna diagnostic test |
US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
GB8920097D0 (en) * | 1989-09-06 | 1989-10-18 | Ici Plc | Amplification processes |
US5104792A (en) * | 1989-12-21 | 1992-04-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for amplifying unknown nucleic acid sequences |
US5516663A (en) | 1990-01-26 | 1996-05-14 | Abbott Laboratories | Ligase chain reaction with endonuclease IV correction and contamination control |
CA2040896C (en) | 1990-04-20 | 2002-01-29 | Edwin F. Ullman | Double receptor polynucleotide assay method |
DK0528882T3 (en) | 1990-05-03 | 2008-01-14 | Cornell Res Foundation Inc | DNA amplification system for detection of genetic diseases by thermostable ligase |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
ATE176002T1 (en) * | 1990-07-24 | 1999-02-15 | Hoffmann La Roche | REDUCING NON-SPECIFIC AMPLIFICATION DURING (IN VITRO) NUCLEIC ACID AMPLIFICATION USING MODIFIED NUCLEIC ACID BASES |
US5484699A (en) * | 1990-09-28 | 1996-01-16 | Abbott Laboratories | Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods |
US5700636A (en) * | 1990-10-19 | 1997-12-23 | Becton Dickinson And Company | Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples |
CA2055755A1 (en) | 1990-11-22 | 1992-05-23 | Toshihiko Kishimoto | Method of immobilizing single-stranded dna on carrier at terminal |
DE69132843T2 (en) * | 1990-12-06 | 2002-09-12 | Affymetrix Inc N D Ges D Staat | Identification of nucleic acids in samples |
DE4039348A1 (en) | 1990-12-10 | 1992-06-11 | Henkel Kgaa | CARPET CLEANER |
WO1992010566A1 (en) | 1990-12-13 | 1992-06-25 | Board Of Regents, The University Of Texas System | In-situ hybridization probes for identification and banding of specific human chromosomes and regions |
EP0566670A4 (en) * | 1990-12-17 | 1993-12-08 | Idexx Laboratories, Inc. | Nucleic acid sequence detection by triple helix formation |
US5290925A (en) * | 1990-12-20 | 1994-03-01 | Abbott Laboratories | Methods, kits, and reactive supports for 3' labeling of oligonucleotides |
RU1794088C (en) * | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Method of dna nucleotide sequence determination and a device for its realization |
AU2170092A (en) * | 1991-05-24 | 1992-12-30 | President And Fellows Of Harvard College, The | Parallel sequential reactor |
US5278298A (en) * | 1991-05-29 | 1994-01-11 | Merck & Co., Inc. | Eimeria brunetti 16s rDNA probes |
GB9112251D0 (en) | 1991-06-07 | 1991-07-24 | Amersham Int Plc | Quantitative detection of nucleic acid amplification products |
DK0519338T3 (en) * | 1991-06-20 | 1996-10-28 | Hoffmann La Roche | Improved Methods for Nucleic Acid Amplification |
US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
WO1993004199A2 (en) | 1991-08-20 | 1993-03-04 | Scientific Generics Limited | Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids |
DE69223980T2 (en) | 1991-10-15 | 1998-05-28 | Multilyte Ltd | BINDING TEST USING A MARKED REAGENT |
DE69232753T2 (en) | 1991-11-01 | 2003-05-15 | Diatech Pty Ltd | SOLIDS PHASE EXPANSION PROCESS |
US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
CA2133220A1 (en) | 1992-03-31 | 1993-10-14 | Stanley R. Bouma | Method of multiplex ligase chain reaction |
WO1993020236A1 (en) | 1992-04-03 | 1993-10-14 | Applied Biosystems, Inc. | Probe composition and method |
US5470705A (en) | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
JPH08503600A (en) | 1992-05-29 | 1996-04-23 | アボツト・ラボラトリーズ | Ligase chain reaction initiated by RNA sequences |
US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
WO1993025563A1 (en) | 1992-06-17 | 1993-12-23 | City Of Hope | A method of detecting and discriminating between nucleic acid sequences |
WO1994001446A2 (en) | 1992-07-09 | 1994-01-20 | Beckman Instruments, Inc. | Derivatized organic solid support for nucleic acid synthesis |
GB9214873D0 (en) | 1992-07-13 | 1992-08-26 | Medical Res Council | Process for categorising nucleotide sequence populations |
EP0654093B1 (en) | 1992-08-03 | 2001-01-03 | Abbott Laboratories | Detecting and amplifying target nucleic acids using exonucleolytic activity |
US6180338B1 (en) | 1992-08-04 | 2001-01-30 | Beckman Coulter, Inc. | Method, reagent and kit for the detection and amplification of nucleic acid sequences |
AU5102993A (en) | 1992-09-18 | 1994-04-12 | Merck & Co., Inc. | Dna encoding murine precursor interleukin 1beta converting enzyme |
WO1994008047A1 (en) | 1992-09-25 | 1994-04-14 | Abbott Laboratories | Ligase chain reaction method for detecting small mutations |
WO1994009022A1 (en) * | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
JP2575270B2 (en) * | 1992-11-10 | 1997-01-22 | 浜松ホトニクス株式会社 | Method for determining base sequence of nucleic acid, method for detecting single molecule, apparatus therefor and method for preparing sample |
US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
WO1994016105A1 (en) | 1993-01-15 | 1994-07-21 | The Public Health Research Institute Of The City Of New York, Inc. | Rna assays using rna binary probes and ribozyme ligase |
EP0682715B1 (en) | 1993-01-15 | 2006-04-05 | The Public Health Research Institute of the City of New York, Inc. | Diagnostic assays and kits for detecting rna using rna binary probes and an rna-directed rna ligase |
WO1994016108A1 (en) | 1993-01-15 | 1994-07-21 | The Public Health Research Institute Of The City Of New York, Inc. | Sensitive nucleic acid sandwich hybridization assays and kits |
WO1994017206A1 (en) * | 1993-01-27 | 1994-08-04 | Oncor, Inc. | Method for amplifying nucleic acid sequences |
EP0686200A4 (en) * | 1993-01-27 | 1997-07-02 | Oncor Inc | Amplification of nucleic acid sequences |
US5985548A (en) | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
DE69413574T2 (en) * | 1993-02-09 | 1999-05-12 | Agfa Gevaert Nv | A processing solution and method for producing a lithographic offset printing plate by the silver salt diffusion transfer process |
US5593826A (en) | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
US5422252A (en) * | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
US6709813B1 (en) | 1993-05-14 | 2004-03-23 | Ortho-Clinical Diagnostics, Inc. | Diagnostic compositions, elements, methods and test kits for amplification and detection of human CMV DNA using primers having matched melting temperatures |
US5652106A (en) * | 1993-06-04 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Rapid amplification-based subtyping of mycobacterium tuberculosis |
DK72493D0 (en) | 1993-06-18 | 1993-06-18 | Risoe Forskningscenter | SOLID SUPPORTS FOR USE IN PEPTIDE SYNTHESIS AND ASSAYS |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
US5731171A (en) * | 1993-07-23 | 1998-03-24 | Arch Development Corp. | Sequence independent amplification of DNA |
US5601978A (en) | 1993-09-03 | 1997-02-11 | Abbott Laboratories | Oligonucleotides and methods for the detection of chlamydia trachomatis |
US5415839A (en) | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
US5352582A (en) * | 1993-10-28 | 1994-10-04 | Hewlett-Packard Company | Holographic based bio-assay |
US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
US5415087A (en) * | 1994-01-21 | 1995-05-16 | Norfolk Southern Railway Co. | Mobile tie banding apparatus |
US5631130A (en) * | 1994-05-13 | 1997-05-20 | Abbott Laboratories | Materials and methods for the detection of Mycobacterium tuberculosis |
WO1995031571A2 (en) | 1994-05-13 | 1995-11-23 | Abbott Laboratories | Materials and methods for the detection of mycobacteria |
US5508168A (en) * | 1994-05-16 | 1996-04-16 | Hoffmann-La Roche Inc. | Methods and reagents for the detection of herpes simplex virus, treponema pallidum, and haemophilus ducreyi |
US7378236B1 (en) | 1994-06-17 | 2008-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for analyzing gene expression patterns |
WO1995035390A1 (en) * | 1994-06-22 | 1995-12-28 | Mount Sinai School Of Medicine Of The City University Of New York | Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes |
US5876924A (en) * | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
US5942391A (en) * | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
US5834181A (en) | 1994-07-28 | 1998-11-10 | Genzyme Corporation | High throughput screening method for sequences or genetic alterations in nucleic acids |
ATE226983T1 (en) * | 1994-08-19 | 2002-11-15 | Pe Corp Ny | COUPLED AMPLICATION AND LIGATION PROCEDURE |
US5648213A (en) | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
US5604097A (en) * | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5512441A (en) * | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
WO1996015271A1 (en) | 1994-11-16 | 1996-05-23 | Abbott Laboratories | Multiplex ligations-dependent amplification |
JP4066200B2 (en) | 1995-06-05 | 2008-03-26 | アクゾ・ノベル・エヌ・ベー | Device and method for detecting microorganisms |
US5667974A (en) | 1995-06-07 | 1997-09-16 | Abbott Laboratories | Method for detecting nucleic acid sequences using competitive amplification |
US5728526A (en) | 1995-06-07 | 1998-03-17 | Oncor, Inc. | Method for analyzing a nucleotide sequence |
WO1996041011A1 (en) | 1995-06-07 | 1996-12-19 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5759779A (en) | 1995-08-29 | 1998-06-02 | Dehlinger; Peter J. | Polynucleotide-array assay and methods |
US5723320A (en) | 1995-08-29 | 1998-03-03 | Dehlinger; Peter J. | Position-addressable polynucleotide arrays |
US5695937A (en) * | 1995-09-12 | 1997-12-09 | The Johns Hopkins University School Of Medicine | Method for serial analysis of gene expression |
US5856096A (en) | 1995-09-20 | 1999-01-05 | Ctrc Research Foundation | Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
WO1997019193A2 (en) | 1995-11-21 | 1997-05-29 | Yale University | Unimolecular segment amplification and detection |
EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | Nucleic acid analysis techniques |
US6962263B2 (en) * | 1996-01-24 | 2005-11-08 | Sambrailo Packaging, Inc. | Produce packaging system having produce containers with double-arched ventilation channels |
US20020150921A1 (en) | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
AU735440B2 (en) | 1996-02-09 | 2001-07-05 | Cornell Research Foundation Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US5868136A (en) | 1996-02-20 | 1999-02-09 | Axelgaard Manufacturing Co. Ltd. | Medical electrode |
EP1736554B1 (en) | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6312892B1 (en) | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
JP2001512483A (en) | 1997-02-25 | 2001-08-21 | イーライ リリー アンド カンパニー | Treatment of infertility with leptin receptor ligand |
US6313048B1 (en) * | 1997-03-03 | 2001-11-06 | Micron Technology, Inc. | Dilute cleaning composition and method for using same |
US5932711A (en) | 1997-03-05 | 1999-08-03 | Mosaic Technologies, Inc. | Nucleic acid-containing polymerizable complex |
US6899889B1 (en) * | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
US7014994B1 (en) | 1999-03-19 | 2006-03-21 | Cornell Research Foundation,Inc. | Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process |
US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
EP1165839A2 (en) | 1999-03-26 | 2002-01-02 | Whitehead Institute For Biomedical Research | Universal arrays |
US20030215821A1 (en) | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
ATE380883T1 (en) | 2000-10-24 | 2007-12-15 | Univ Leland Stanford Junior | DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA |
-
1997
- 1997-05-27 EP EP06011667.0A patent/EP1736554B1/en not_active Expired - Lifetime
- 1997-05-27 AU AU32160/97A patent/AU730633B2/en not_active Expired
- 1997-05-27 JP JP54287897A patent/JP4468488B2/en not_active Expired - Lifetime
- 1997-05-27 EP EP10075461.3A patent/EP2369007B1/en not_active Expired - Lifetime
- 1997-05-27 WO PCT/US1997/009012 patent/WO1997045559A1/en not_active Application Discontinuation
- 1997-05-27 EP EP97927787A patent/EP0912761A4/en not_active Withdrawn
- 1997-05-27 CA CA002255774A patent/CA2255774C/en not_active Expired - Lifetime
- 1997-05-28 US US08/864,473 patent/US6027889A/en not_active Expired - Lifetime
-
1999
- 1999-11-15 US US09/440,523 patent/US6268148B1/en not_active Expired - Lifetime
-
2001
- 2001-07-30 US US09/918,156 patent/US6797470B2/en not_active Expired - Lifetime
-
2004
- 2004-05-12 US US10/843,720 patent/US7166434B2/en not_active Expired - Fee Related
- 2004-05-24 US US10/852,289 patent/US7097980B2/en not_active Expired - Fee Related
-
2005
- 2005-09-16 US US11/229,366 patent/US7429453B2/en not_active Expired - Fee Related
-
2006
- 2006-10-31 US US11/590,529 patent/US7364858B2/en not_active Expired - Fee Related
- 2006-10-31 US US11/590,383 patent/US7332285B2/en not_active Expired - Fee Related
- 2006-10-31 US US11/590,056 patent/US7312039B2/en not_active Expired - Fee Related
- 2006-10-31 US US11/590,384 patent/US7320865B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/931,403 patent/US7556924B2/en not_active Expired - Fee Related
-
2008
- 2008-01-04 JP JP2008000124A patent/JP4781372B2/en not_active Expired - Lifetime
-
2009
- 2009-07-01 US US12/496,447 patent/US8283121B2/en not_active Expired - Fee Related
-
2011
- 2011-04-22 JP JP2011096201A patent/JP5634936B2/en not_active Expired - Lifetime
-
2012
- 2012-06-14 US US13/523,252 patent/US8597890B2/en not_active Expired - Fee Related
- 2012-07-06 US US13/543,432 patent/US8642269B2/en not_active Expired - Fee Related
- 2012-07-06 US US13/543,365 patent/US8597891B2/en not_active Expired - Fee Related
-
2013
- 2013-05-01 US US13/874,697 patent/US8802373B2/en not_active Expired - Fee Related
-
2014
- 2014-07-03 US US14/323,716 patent/US20140315757A1/en not_active Abandoned
- 2014-09-26 US US14/498,448 patent/US20150018249A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US5407798A (en) * | 1990-10-16 | 1995-04-18 | Ciba Corning Diagnostics Corp. | Amplification of midivariant DNA templates |
WO1993017126A1 (en) * | 1992-02-19 | 1993-09-02 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5593840A (en) * | 1993-01-27 | 1997-01-14 | Oncor, Inc. | Amplification of nucleic acid sequences |
US5536649A (en) * | 1993-05-11 | 1996-07-16 | Becton, Dickinson And Company | Decontamination of nucleic acid amplification reactions using uracil-N-glycosylase (UDG) |
Non-Patent Citations (1)
Title |
---|
See also references of EP0912761A4 * |
Cited By (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
US9400259B2 (en) | 1996-04-25 | 2016-07-26 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US8691594B2 (en) | 1996-04-25 | 2014-04-08 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
EP0956359A1 (en) * | 1996-07-19 | 1999-11-17 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
EP0956359A4 (en) * | 1996-07-19 | 2004-12-01 | Cornell Res Foundation Inc | High fidelity detection of nucleic acid differences by ligase detection reaction |
US7244831B2 (en) | 1996-07-19 | 2007-07-17 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
US9902951B2 (en) | 1997-04-01 | 2018-02-27 | Illumina, Inc. | Method of nucleic acid amplification |
US8993271B2 (en) | 1997-04-01 | 2015-03-31 | Illumina, Inc. | Method of nucleic acid amplification |
US9593328B2 (en) | 1997-04-01 | 2017-03-14 | Illumina, Inc. | Method of nucleic acid amplification |
US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
US9399795B2 (en) | 1998-06-24 | 2016-07-26 | Illumina, Inc. | Multiplex decoding of array sensors with microspheres |
US8541218B2 (en) | 1998-10-30 | 2013-09-24 | Cornell Research Foundation, Inc. | High fidelity thermostable ligase and uses thereof |
US6949370B1 (en) | 1998-10-30 | 2005-09-27 | Cornell Research Foundation, Inc. | High fidelity thermostable ligase and uses thereof |
US9127269B2 (en) | 1998-10-30 | 2015-09-08 | Cornell Research Foundation, Inc. | High fidelity thermostable ligase and uses thereof |
US6395486B1 (en) | 1999-03-15 | 2002-05-28 | Applera Corporation | Probe/mobility modifier complexes for multiplexnucleic acid detection |
US6734296B1 (en) | 1999-03-15 | 2004-05-11 | Applera Corporation | Probe/mobility modifier complexes for multiplex nucleic acid detection |
WO2000055368A3 (en) * | 1999-03-15 | 2001-04-05 | Perkin Elmer Corp | Probe/mobility modifier complexes for multiplex nucleic acid detection |
WO2000055368A2 (en) * | 1999-03-15 | 2000-09-21 | Pe Corporation (Ny) | Probe/mobility modifier complexes for multiplex nucleic acid detection |
JP2003510011A (en) * | 1999-03-19 | 2003-03-18 | コーネル リサーチ ファンデーション インク. | Coupled polymerase chain reaction-restriction endonuclease digestion-ligase detection reaction |
US9441267B2 (en) | 1999-04-20 | 2016-09-13 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US9279148B2 (en) | 1999-04-20 | 2016-03-08 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
EP1194592A4 (en) * | 1999-07-14 | 2004-12-08 | Packard Bioscience Company | Derivative nucleic acids and uses thereof |
EP1194592A1 (en) * | 1999-07-14 | 2002-04-10 | Packard Bioscience Company | Derivative nucleic acids and uses thereof |
US7550276B2 (en) | 1999-10-04 | 2009-06-23 | Olympus Corporation | Method of detecting nucleic acid |
EP1136568A1 (en) * | 1999-10-04 | 2001-09-26 | Olympus Optical Corporation Limited | Method of detecting nucleic acid |
EP1136568A4 (en) * | 1999-10-04 | 2004-12-15 | Olympus Optical Corp Ltd | Method of detecting nucleic acid |
EP1221491A1 (en) * | 1999-10-12 | 2002-07-10 | Precision System Science Co., Ltd. | SUSPENSION SYSTEM FOR SEQUENCING GENETIC SUBSTANCE, METHOD OF SEQUENCING GENETIC SUBSTANCE BY USING THE SUSPENSION SYSTEM, AND METHOD OF HIGH-SPEED SNPs SCORING BY USING THE SUSPENSION SYSTEM |
EP1221491A4 (en) * | 1999-10-12 | 2003-04-16 | Prec System Science Co Ltd | SUSPENSION SYSTEM FOR SEQUENCING GENETIC SUBSTANCE, METHOD OF SEQUENCING GENETIC SUBSTANCE BY USING THE SUSPENSION SYSTEM, AND METHOD OF HIGH-SPEED SNPs SCORING BY USING THE SUSPENSION SYSTEM |
US8906626B2 (en) | 2000-02-07 | 2014-12-09 | Illumina, Inc. | Multiplex nucleic acid reactions |
US10837059B2 (en) | 2000-02-07 | 2020-11-17 | Illumina, Inc. | Multiplex nucleic acid reactions |
WO2001057269A2 (en) * | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
JP2003521252A (en) * | 2000-02-07 | 2003-07-15 | イルミナ インコーポレイテッド | Nucleic acid detection method using universal priming |
WO2001057268A2 (en) * | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
US6812005B2 (en) | 2000-02-07 | 2004-11-02 | The Regents Of The University Of California | Nucleic acid detection methods using universal priming |
US9850536B2 (en) | 2000-02-07 | 2017-12-26 | Illumina, Inc. | Multiplex nucleic acid reactions |
EP1990428A1 (en) * | 2000-02-07 | 2008-11-12 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
WO2001057269A3 (en) * | 2000-02-07 | 2002-07-18 | Illumina Inc | Nucleic acid detection methods using universal priming |
WO2001057268A3 (en) * | 2000-02-07 | 2002-07-18 | Illumina Inc | Nucleic acid detection methods using universal priming |
US6890741B2 (en) | 2000-02-07 | 2005-05-10 | Illumina, Inc. | Multiplexed detection of analytes |
US7361488B2 (en) | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
EP1130113A1 (en) * | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
US6955901B2 (en) * | 2000-02-15 | 2005-10-18 | De Luwe Hoek Octrooien B.V. | Multiplex ligatable probe amplification |
WO2001061033A3 (en) * | 2000-02-15 | 2002-03-28 | Johannes Petrus Schouten | Multiplex ligatable probe amplification |
US7803537B2 (en) | 2000-02-16 | 2010-09-28 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
US7285384B2 (en) | 2000-02-16 | 2007-10-23 | Illuminia, Inc. | Parallel genotyping of multiple patient samples |
US7482443B2 (en) * | 2000-03-09 | 2009-01-27 | Genetag Technology, Inc. | Systems and methods to quantify and amplify both signaling probes for cDNA chips and genes expression microarrays |
US7455965B2 (en) | 2000-04-14 | 2008-11-25 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
US10131938B2 (en) | 2000-04-14 | 2018-11-20 | Cornell Research Foundation, Inc. | Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction |
US9340834B2 (en) | 2000-04-14 | 2016-05-17 | Cornell Research Foundation, Inc. | Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction |
US9725759B2 (en) | 2000-04-14 | 2017-08-08 | Cornell Research Foundation, Inc. | Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction |
US8492085B2 (en) | 2000-04-14 | 2013-07-23 | Cornell Research Foundation, Inc. | Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction |
WO2001085987A1 (en) * | 2000-05-09 | 2001-11-15 | Diatech Pty. Ltd. | Methods for identifying polynucleotide repeat regions of defined length |
WO2001092579A2 (en) * | 2000-05-30 | 2001-12-06 | Pe Corporation (Ny) | Methods for detecting target nucleic acids using coupled ligation and amplification |
WO2001092579A3 (en) * | 2000-05-30 | 2003-03-20 | Pe Corp Ny | Methods for detecting target nucleic acids using coupled ligation and amplification |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
WO2002002815A1 (en) * | 2000-07-05 | 2002-01-10 | Toyo Boseki Kabushiki Kaisha | Method of detecting nucleotide polymorphism |
EP1229128A1 (en) * | 2001-01-31 | 2002-08-07 | Boehringer Mannheim Gmbh | New method for genotype determination |
WO2002061122A2 (en) * | 2001-01-31 | 2002-08-08 | Roche Diagnostics Gmbh | New method for genotype determination |
WO2002061122A3 (en) * | 2001-01-31 | 2002-11-14 | Roche Diagnostics Gmbh | New method for genotype determination |
EP1247815A3 (en) * | 2001-03-25 | 2003-01-29 | Exiqon A/S | Modified oligonucleotides and uses thereof |
EP1247815A2 (en) * | 2001-03-25 | 2002-10-09 | Exiqon A/S | Modified oligonucleotides and uses thereof |
US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
US10415081B2 (en) | 2001-10-15 | 2019-09-17 | Bioarray Solutions Ltd. | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US7510829B2 (en) | 2001-11-19 | 2009-03-31 | Affymetrix, Inc. | Multiplex PCR |
EP1456416A2 (en) * | 2001-11-19 | 2004-09-15 | Parallele Bioscience, Inc. | Multiplex oligonucleotide addition and target amplification |
US10407717B2 (en) | 2001-11-19 | 2019-09-10 | Affymetrix, Inc. | Methods of analysis of methylation |
US7754451B2 (en) | 2001-11-19 | 2010-07-13 | Affymetrix, Inc. | Multiplex oligonucleotide addition and target amplification |
EP1456416A4 (en) * | 2001-11-19 | 2006-01-11 | Parallele Bioscience Inc | Multiplex oligonucleotide addition and target amplification |
US10822642B2 (en) | 2001-11-19 | 2020-11-03 | Affymetrix, Inc. | Methods of analysis of methylation |
US7208295B2 (en) | 2001-11-19 | 2007-04-24 | Affymetrix, Inc. | Multiplex oligonucleotide addition and target amplification |
EP1319718A1 (en) * | 2001-12-14 | 2003-06-18 | Keygene N.V. | High throughput analysis and detection of multiple target sequences |
WO2003052140A2 (en) * | 2001-12-14 | 2003-06-26 | Keygene N.V. | High throughput analysis and detection of multiple target sequences |
WO2003052140A3 (en) * | 2001-12-14 | 2003-11-13 | Keygene Nv | High throughput analysis and detection of multiple target sequences |
WO2003060163A2 (en) * | 2001-12-28 | 2003-07-24 | Keygene N.V. | Discrimination and detection of target nucleotide sequences using mass spectrometry |
WO2003060163A3 (en) * | 2001-12-28 | 2003-12-11 | Keygene Nv | Discrimination and detection of target nucleotide sequences using mass spectrometry |
EP2210665A1 (en) | 2002-01-16 | 2010-07-28 | CLONDIAG GmbH | Apparatus for detecting target molecules |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US8592214B2 (en) | 2003-01-21 | 2013-11-26 | Illumina, Inc. | Chemical reaction monitor |
US7887752B2 (en) | 2003-01-21 | 2011-02-15 | Illumina, Inc. | Chemical reaction monitor |
EP2266699A1 (en) | 2003-04-02 | 2010-12-29 | CLONDIAG GmbH | Device for the amplification and detection of nucleic acids |
US7799525B2 (en) | 2003-06-17 | 2010-09-21 | Human Genetic Signatures Pty Ltd. | Methods for genome amplification |
US8808991B2 (en) | 2003-09-02 | 2014-08-19 | Keygene N.V. | Ola-based methods for the detection of target nucleic avid sequences |
WO2005021794A2 (en) * | 2003-09-02 | 2005-03-10 | Keygene N.V. | Ola-based methods for the detection of target nucleic acid sequences |
WO2005021794A3 (en) * | 2003-09-02 | 2005-05-19 | Keygene Nv | Ola-based methods for the detection of target nucleic acid sequences |
EP1668148A1 (en) * | 2003-09-04 | 2006-06-14 | Human Genetic Signatures PTY Ltd. | Nucleic acid detection assay |
US7846693B2 (en) | 2003-09-04 | 2010-12-07 | Human Genetic Signatures Pty. Ltd. | Nucleic acid detection assay |
EP1668148A4 (en) * | 2003-09-04 | 2007-11-14 | Human Genetic Signatures Pty | Nucleic acid detection assay |
US8691754B2 (en) | 2003-09-22 | 2014-04-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US9637777B2 (en) | 2003-10-28 | 2017-05-02 | Bioarray Solutions, Ltd. | Optimization of gene expression analysis using immobilized capture probes |
EP2241639A2 (en) | 2004-01-26 | 2010-10-20 | CLONDIAG GmbH | Method for genotyping and pathotyping pseudomonas aeruginosa |
EP1718766A2 (en) * | 2004-02-10 | 2006-11-08 | Cornell Research Foundation, Inc. | Method for detection of promoter methylation status |
US7358048B2 (en) | 2004-02-10 | 2008-04-15 | Cornell Research Foundation, Inc. | Method for detection of promoter methylation status |
EP1718766A4 (en) * | 2004-02-10 | 2009-05-27 | Cornell Res Foundation Inc | Method for detection of promoter methylation status |
WO2005092038A3 (en) * | 2004-03-22 | 2006-06-01 | Univ Johns Hopkins | Methods for the detection of nucleic acid differences |
WO2005092038A2 (en) * | 2004-03-22 | 2005-10-06 | The Johns Hopkins University | Methods for the detection of nucleic acid differences |
US8679788B2 (en) | 2004-03-22 | 2014-03-25 | The Johns Hopkins University | Methods for the detection of nucleic acid differences |
US8168777B2 (en) | 2004-04-29 | 2012-05-01 | Human Genetic Signatures Pty. Ltd. | Bisulphite reagent treatment of nucleic acid |
WO2005118862A3 (en) * | 2004-04-30 | 2006-07-13 | Applera Corp | Compositions, methods, and kits for (mis)ligating oligonucleotides |
WO2005118862A2 (en) * | 2004-04-30 | 2005-12-15 | Applera Corporation | Compositions, methods, and kits for (mis)ligating oligonucleotides |
EP2299257A2 (en) | 2004-05-06 | 2011-03-23 | CLONDIAG GmbH | Device and method for detecting molecular interactions |
EP3527287A1 (en) | 2004-05-06 | 2019-08-21 | Alere Technologies GmbH | Method for detecting molecular interactions |
EP3171155A1 (en) | 2004-05-06 | 2017-05-24 | Clondiag GmbH | Device and method for detecting molecular interactions |
EP2290351A2 (en) | 2004-05-06 | 2011-03-02 | CLONDIAG GmbH | Device and method for detecting molecular interactions |
EP2280267A2 (en) | 2004-05-06 | 2011-02-02 | CLONDIAG GmbH | Device and method for detecting molecular interactions |
EP2256478A2 (en) | 2004-05-06 | 2010-12-01 | CLONDIAG GmbH | Device and method for detecting molecular interactions |
WO2006005055A2 (en) * | 2004-06-30 | 2006-01-12 | Applera Corporation | Methods reaction mixtures and kits for ligating polynucleotides |
WO2006005055A3 (en) * | 2004-06-30 | 2006-03-16 | Applera Corp | Methods reaction mixtures and kits for ligating polynucleotides |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US7803580B2 (en) | 2004-09-10 | 2010-09-28 | Human Genetic Signatures Pty. Ltd. | Amplification blocker comprising intercalating nucleic acids (INA) containing intercalating pseudonucleotides (IPN) |
US7833942B2 (en) | 2004-12-03 | 2010-11-16 | Human Genetic Signatures Pty. Ltd. | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
US8598088B2 (en) | 2004-12-03 | 2013-12-03 | Human Genetic Signatures Pty. Ltd. | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
US8431347B2 (en) | 2005-05-26 | 2013-04-30 | Human Genetic Signatures Pty Ltd | Isothermal strand displacement amplification using primers containing a non-regular base |
US8343738B2 (en) | 2005-09-14 | 2013-01-01 | Human Genetic Signatures Pty. Ltd. | Assay for screening for potential cervical cancer |
EP2330215A1 (en) | 2005-11-04 | 2011-06-08 | CLONDIAG GmbH | Method and device for the detection of molecular interactions |
US8236498B2 (en) | 2006-01-20 | 2012-08-07 | Olympus Corporation | Method of detecting nucleotide sequence with an intramolecular probe |
WO2008118998A2 (en) * | 2007-03-27 | 2008-10-02 | Primera Biosystems Inc. | Method for multiplex detection and quantitation of nucleic acids |
WO2008118998A3 (en) * | 2007-03-27 | 2008-11-27 | Primera Biosystems Inc | Method for multiplex detection and quantitation of nucleic acids |
US8685675B2 (en) | 2007-11-27 | 2014-04-01 | Human Genetic Signatures Pty. Ltd. | Enzymes for amplification and copying bisulphite modified nucleic acids |
EP2356245A4 (en) * | 2008-11-07 | 2013-02-20 | Univ Utah Res Found | Allele amplification bias |
US9422597B2 (en) | 2008-11-07 | 2016-08-23 | Biofire Diagnostics, Inc. | Allele amplification bias |
US10351903B2 (en) | 2008-11-07 | 2019-07-16 | University Of Utah Research Foundation | Allele amplification bias |
EP2356245A1 (en) * | 2008-11-07 | 2011-08-17 | University Of Utah Research Foundation | Allele amplification bias |
US10422001B2 (en) | 2011-07-08 | 2019-09-24 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
WO2013009175A1 (en) | 2011-07-08 | 2013-01-17 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US11873529B2 (en) | 2011-07-08 | 2024-01-16 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US10988807B2 (en) | 2011-07-08 | 2021-04-27 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
EP2980226A1 (en) | 2011-07-08 | 2016-02-03 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US9777322B2 (en) | 2011-07-08 | 2017-10-03 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US9732375B2 (en) | 2011-09-07 | 2017-08-15 | Human Genetic Signatures Pty. Ltd. | Molecular detection assay using direct treatment with a bisulphite reagent |
WO2013095119A1 (en) | 2011-12-14 | 2013-06-27 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Identification of poliovirus strains |
EP3287531A1 (en) * | 2012-02-28 | 2018-02-28 | Agilent Technologies, Inc. | Method for attaching a counter sequence to a nucleic acid sample |
WO2013128281A1 (en) * | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
US9670529B2 (en) | 2012-02-28 | 2017-06-06 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
US10626441B2 (en) | 2012-02-28 | 2020-04-21 | Agilent Technologies, Inc. | Method for attaching a counter sequence to a nucleic acid sample |
US9551038B2 (en) | 2012-05-11 | 2017-01-24 | K-Mac | System for integrated analysis of real-time polymerase chain reaction and DNA chip and method for integrated analysis using the same |
CN103388023A (en) * | 2012-05-11 | 2013-11-13 | 科美仪器 | System for integrated analysis of real-time polymerase chain reaction and DNA chip and method for integrated analysis using the same |
CN103388023B (en) * | 2012-05-11 | 2015-09-16 | 科美仪器 | The integrated analysis system of real-time polymerase chain reaction and DNA chip and use its integrated analysis method |
US10059983B2 (en) | 2012-09-10 | 2018-08-28 | Genesky Diagnostics (Suzhou) Inc. | Multiplex nucleic acid analysis |
EP2893034A4 (en) * | 2012-09-10 | 2016-04-13 | Genesky Diagnostics Suzhou Inc | Method for multiplex nucleic acid analysis |
EP2893034A1 (en) * | 2012-09-10 | 2015-07-15 | Genesky Diagnostics (Suzhou) Inc. | Method for multiplex nucleic acid analysis |
WO2015185564A1 (en) * | 2014-06-02 | 2015-12-10 | Base4 Innovation Ltd | Nucleotide polymorphism detection method |
CN106460057A (en) * | 2014-06-02 | 2017-02-22 | 贝斯4创新公司 | Nucleotide polymorphism detection method |
US10227638B2 (en) | 2014-06-02 | 2019-03-12 | Base4 Innovation Ltd. | Nucleotide polymorphism detection method |
AU2015330844B2 (en) * | 2014-10-08 | 2022-02-03 | Cornell University | Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes |
US11466311B2 (en) | 2014-10-08 | 2022-10-11 | Cornell University | Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes |
CN107002145A (en) * | 2014-10-08 | 2017-08-01 | 康奈尔大学 | Method for use for leaving combination nuclease, coupled reaction and polymeric enzyme reaction identification and the expression of relative quantification nucleotide sequence, splice variant, transposition, copy number or the change that methylates of prevention |
EP4026914A1 (en) * | 2014-10-08 | 2022-07-13 | Cornell University | Method for identification and relative quantification of nucleic acid methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention |
EP3204520A4 (en) * | 2014-10-08 | 2018-03-07 | Cornell University | Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes |
EP3690060A1 (en) * | 2014-10-08 | 2020-08-05 | Cornell University | Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention |
US10344321B2 (en) | 2014-10-08 | 2019-07-09 | Cornell University | Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes |
US11542506B2 (en) | 2014-11-14 | 2023-01-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
JP2016140288A (en) * | 2015-01-30 | 2016-08-08 | 倉敷紡績株式会社 | Preparation method of single stranded dna product |
WO2016121907A1 (en) * | 2015-01-30 | 2016-08-04 | 倉敷紡績株式会社 | Method for preparing single-stranded dna product |
WO2018127408A1 (en) | 2017-01-05 | 2018-07-12 | Tervisetehnoloogiate Arenduskeskus As | Quantifying dna sequences |
WO2018172348A1 (en) * | 2017-03-21 | 2018-09-27 | Sequencing Multiplex Sl | Easy one-step amplification and labeling (eosal) |
EP3378950A1 (en) * | 2017-03-21 | 2018-09-26 | Sequencing Multiplex SLK | Easy one-step amplification and labeling (eosal) |
US11603542B2 (en) | 2017-05-05 | 2023-03-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
WO2019238765A1 (en) | 2018-06-12 | 2019-12-19 | Keygene N.V. | Nucleic acid amplification method |
WO2020169830A1 (en) | 2019-02-21 | 2020-08-27 | Keygene N.V. | Genotyping of polyploids |
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