WO1997022315A1 - Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) - Google Patents
Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) Download PDFInfo
- Publication number
- WO1997022315A1 WO1997022315A1 PCT/EP1996/005410 EP9605410W WO9722315A1 WO 1997022315 A1 WO1997022315 A1 WO 1997022315A1 EP 9605410 W EP9605410 W EP 9605410W WO 9722315 A1 WO9722315 A1 WO 9722315A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- web
- sections
- active substance
- transfer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/19—Delaminating means
- Y10T156/1961—Severing delaminating means [e.g., chisel, etc.]
- Y10T156/1967—Cutting delaminating means
Definitions
- TTS transdermal therapeutic patches
- the invention relates to a method for producing transdermal therapeutic plasters (TTS) according to the preamble of claim 1.
- TTS transdermal therapeutic plasters
- DE-PS 32 04 582 discloses a process for the continuous manufacture and filling of plaster packs with an active ingredient to be administered transdermally.
- the active ingredient is applied in portions to a carrier film at certain intervals, covered by means of metallic cover film sections and then covered with an elastic adhesive film which is directed against the adhesive side on one side and then the active ingredient portions with those surrounding them using an interlayer film Foil layers punched out in the desired size.
- This method requires a relatively large amount of technical effort and is associated with relatively large amounts of superfluous material.
- transdermal therapeutic plasters in which a laminate is first produced by coating an intermediate carrier film with a flowable preparation containing active substance, and this is then made into strips of predetermined width and, in further process steps, into sections of a certain length containing active substance cut to size, applied at predetermined intervals to a protective film covering it on all sides and finally divided into individual plasters between the active substance-containing sections by separating the protective film transversely to the band.
- the aim of the present invention is therefore to transfer individual active substance-containing sections with high speed, great accuracy and without loss of active substance from a first web at predetermined intervals one after the other to a second web that is preferably superior on all sides, in a technically simple and reliable manner, it must be avoided that the wearing comfort of the end product is impaired by a polymer film lying within the TTS.
- the individual layers can be designed to be self-adhesive or also adhesive-repellent, active substance-permeable or also active substance-impermeable, flexible or not flexible, depending on their respective purpose.
- Sections containing the active substance can have different shapes, such as rectangular, square, oval or circular. In order to avoid loss of active ingredient, however, a rectangular or square shape is preferred.
- a protective layer of the active substance-containing layer to be removed before use can consist, for example, of the same materials as those used for producing the backing layer. However, these must be made removable, for example by a silicone treatment.
- Other removable protective layers are, for example, tetrafluoroethylene, treated paper, cellophane, polyvinyl chloride and the like.
- the process and auxiliary layers can be made of the same materials.
- the pressure-sensitive adhesive layers can be made, for example, from a polymer matrix with a base polymer and, if appropriate, conventional additives. Suitable materials are e.g. Silicones, rubber, rubber-like synthetic homo-, co- or block polymers, polyacrylates and their copolymers and also esters of hydrogenated rosin. In principle, all polymers come into question which are used in the production of pressure sensitive adhesives and are physiologically harmless. Particular preference is given to those which consist as block copolymers based on styrene and 1,3-diene, polyisobutylene or polymers and copolymers of acrylate and / or methacrylate. Of the block copolymers based on styrene and 1,3-diene, linear styrene-isoprene-styrene block copolymers are preferably used.
- Substances which are applied to the skin without or with absorption mediators and which have a local or systemic effect are used as active ingredients.
- Substances with a local effect are e.g. Antiperspirants, fungicides, bactericides and bacteriostatics.
- Substances with a systemic effect are, for example, antibiotics, hormones, antipyretics, antidiabetics, coronard dila- gators, cardioactive güykoeide, spammolytic, antihyportonic, psychopharmaceutical, migraine, corticoid, analgesic, contraceptive, antirheumatic, cholinergic or anticholinergic, sympathomimetic or symphaticolytic, vasodilator, anticoagulant or antiarrhythmic or antiarrhythmic.
- active ingredients are also possible.
- (1) denotes the first sheet-like laminate or the first sheet, these being from top to bottom of an auxiliary layer of film (3) which is siliconized on at least one side, an adhesive layer (4) containing active ingredient and a backing layer (9) (at least siliconized on one side).
- the film (3) and the active substance-containing layer (4) are cut perpendicular to the web direction with a straight cut using a cutting device, so that, for example, square sections (3 ', 4') are formed.
- the siliconized carrier layer (9) is not cut through.
- the first web (1) is transported in the movement phase from right to left with the aid of a pair of pliers, instead of which a roller preferred or the like can also be provided, and then held down with the aid of a hold-down device. Immediately after cutting through the layers
- the laminate (5) consisting of a process film equipped with a pressure-sensitive adhesive, is laminated to the web-like laminate (1) on the side of the layer (3).
- the individual plaster is punched out by cutting through the layers (13) and (14) but not (2).
- the active ingredient-containing pressure-sensitive adhesive layer (4) can contain, for example at a thickness of 100 g / m 2, 57% solution polyacrylate, 25% plasticizer, 10% polymethacrylate and 8% physostigmine. With a web width of 35 mm, there is the possibility of obtaining square plaster formats (4 ') of 35 x 35 mm.
- the second web (2) is about 55 mm wide and can be formed from polyester film (PET) siliconized on both sides.
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU11763/97A AU709517B2 (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal patches (TTS) |
AT96942340T ATE213144T1 (de) | 1995-12-20 | 1996-12-04 | Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) |
SK675-98A SK282988B6 (sk) | 1995-12-20 | 1996-12-04 | Spôsob výroby transdermálnych terapeutických náplastí |
IL12461896A IL124618A (en) | 1995-12-20 | 1996-12-04 | A process for making legumes for insertion through the skin |
HU0000209A HU225104B1 (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal patches (tts) |
NZ324305A NZ324305A (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal therapeutic patches (TTS) |
SI9630464T SI0959834T1 (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal patches (tts) |
PL96327602A PL183410B1 (pl) | 1995-12-20 | 1996-12-04 | Sposób wytwarzania transdermalnych plastrów terapeutycznych |
DE59608749T DE59608749D1 (de) | 1995-12-20 | 1996-12-04 | Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) |
KR10-1998-0704545A KR100439921B1 (ko) | 1995-12-20 | 1996-12-04 | 트랜스더 멀패치의 제조방법 |
JP52246397A JP3585128B2 (ja) | 1995-12-20 | 1996-12-04 | 経皮治療用パッチ(tts)の製造方法 |
US09/091,696 US6059913A (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal patches (TTS) |
DK96942340T DK0959834T3 (da) | 1995-12-20 | 1996-12-04 | Fremgangsmåde til fremstilling af transdermale, terapeutiske plastre (TTS) |
EP96942340A EP0959834B1 (de) | 1995-12-20 | 1996-12-04 | Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) |
CA002240416A CA2240416C (en) | 1995-12-20 | 1996-12-04 | Method for producing transdermal patches |
NO19982844A NO311636B1 (no) | 1995-12-20 | 1998-06-19 | Fremgangsmåte for å fremstille transdermale plaster (TTS) |
HK00103356A HK1026356A1 (en) | 1995-12-20 | 2000-06-01 | Method for producing transdermal patches (tts) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19547691A DE19547691C1 (de) | 1995-12-20 | 1995-12-20 | Verfahren zur Herstellung transdermaler therapeutischer Pflaster (TTS) |
DE19547691.3 | 1995-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997022315A1 true WO1997022315A1 (de) | 1997-06-26 |
Family
ID=7780735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/005410 WO1997022315A1 (de) | 1995-12-20 | 1996-12-04 | Verfahren zur herstellung transdermaler therapeutischer pflaster (tts) |
Country Status (24)
Country | Link |
---|---|
US (1) | US6059913A (de) |
EP (1) | EP0959834B1 (de) |
JP (1) | JP3585128B2 (de) |
KR (1) | KR100439921B1 (de) |
CN (1) | CN1130172C (de) |
AT (1) | ATE213144T1 (de) |
AU (1) | AU709517B2 (de) |
CA (1) | CA2240416C (de) |
CZ (1) | CZ289083B6 (de) |
DE (2) | DE19547691C1 (de) |
DK (1) | DK0959834T3 (de) |
ES (1) | ES2172698T3 (de) |
HK (1) | HK1026356A1 (de) |
HU (1) | HU225104B1 (de) |
IL (1) | IL124618A (de) |
MX (1) | MX9804996A (de) |
MY (1) | MY113548A (de) |
NO (1) | NO311636B1 (de) |
NZ (1) | NZ324305A (de) |
PL (1) | PL183410B1 (de) |
PT (1) | PT959834E (de) |
SK (1) | SK282988B6 (de) |
WO (1) | WO1997022315A1 (de) |
ZA (1) | ZA9610666B (de) |
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WO2001022946A2 (de) * | 1999-09-28 | 2001-04-05 | Lts Lohmann Therapie-Systeme Ag | Verfahren und vorrichtung zum spenden haftklebender laminatabschnitte |
JP2002530216A (ja) * | 1998-11-21 | 2002-09-17 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 扁平形態物品を給送する方法および装置 |
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US6464818B1 (en) * | 1996-10-04 | 2002-10-15 | Tesa Ag | Method of wasteless punching of adhesive punched items |
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CN100425216C (zh) * | 2003-02-13 | 2008-10-15 | 上海东月医疗保健用品有限公司 | 充填式加强型疤痕贴的制备方法 |
US7890604B2 (en) | 2004-05-07 | 2011-02-15 | Microsoft Corproation | Client-side callbacks to server events |
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EP1888048B1 (de) * | 2005-06-10 | 2012-01-04 | 3M Innovative Properties Company | Verfahren zur handhabung von klebenden laminatabschnitten |
TWI289059B (en) * | 2006-01-24 | 2007-11-01 | Tsung-Ching Shiu | Prototype machine for in time manufacturing of functional adhesive patch in germ-free room |
KR100796676B1 (ko) | 2006-08-25 | 2008-01-21 | 김승자 | 토르말린 함유 패치의 제조장치 |
WO2009024284A2 (de) * | 2007-08-21 | 2009-02-26 | Lts Lohmann Therapie-Systeme Ag | Verfahren zum mehrspurigen konfektionieren transdermaler therapeutischer pflaster |
ES2400210T3 (es) * | 2008-10-02 | 2013-04-08 | Mylan Inc. | Método para preparar un laminado de adhesivo multicapa |
WO2012040262A1 (en) * | 2010-09-23 | 2012-03-29 | Monosol Rx, Llc | Method and system for forming a pharmaceutical product directly onto a packaging surface |
JP5240348B2 (ja) * | 2011-11-07 | 2013-07-17 | トヨタ自動車株式会社 | 膜電極接合体の製造方法 |
KR102309244B1 (ko) | 2013-02-20 | 2021-10-05 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
CN105793957B (zh) | 2013-12-12 | 2019-05-03 | 株式会社半导体能源研究所 | 剥离方法及剥离装置 |
WO2016086095A1 (en) * | 2014-11-25 | 2016-06-02 | Biodelivery Sciences International, Inc. | Patches, methods for forming and testing pharmaceutical agent delivery patches |
WO2016099986A2 (en) | 2014-12-18 | 2016-06-23 | 3M Innovative Properties Company | Methods of handling adhesive laminate patches |
EP3744491A1 (de) * | 2019-05-27 | 2020-12-02 | LTS Lohmann Therapie-Systeme AG | Werkzeugsatz zur herstellung von klebepflastern, verfahren zur herstellung eines klebepflasters und klebeschichten |
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GB2237262A (en) * | 1989-10-25 | 1991-05-01 | Osaka Sealing Label Print | Manufacturing labels on a continuous web |
DE4232279C1 (de) * | 1992-09-25 | 1993-10-21 | Lohmann Therapie Syst Lts | Transferverfahren zur Herstellung transdermaler therapeutischer Systeme |
WO1995023687A1 (de) * | 1994-03-03 | 1995-09-08 | Lts Lohmann Therapie-Systeme Gmbh | Vorrichtung zur übertragung von einseitig selbstklebenden abschnitten von einer bewegten ersten bahn auf eine bewegte zweite bahn |
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DE3204582A1 (de) * | 1982-02-10 | 1983-08-25 | Hassia Verpackung Gmbh, 6479 Ranstadt | Verfahren zur kontinuierlichen herstellung von pflasterpackungen fuer die transdermale verabreichung von medikamenten |
DE4110027C2 (de) * | 1991-03-27 | 1996-08-29 | Lohmann Therapie Syst Lts | Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster |
JP3156419B2 (ja) * | 1993-02-15 | 2001-04-16 | 松下電器産業株式会社 | 異方性導電フィルム保護用セパレータの剥離方法 |
-
1995
- 1995-12-20 DE DE19547691A patent/DE19547691C1/de not_active Expired - Fee Related
-
1996
- 1996-12-04 AU AU11763/97A patent/AU709517B2/en not_active Ceased
- 1996-12-04 DE DE59608749T patent/DE59608749D1/de not_active Expired - Lifetime
- 1996-12-04 KR KR10-1998-0704545A patent/KR100439921B1/ko not_active IP Right Cessation
- 1996-12-04 CZ CZ19981710A patent/CZ289083B6/cs not_active IP Right Cessation
- 1996-12-04 ES ES96942340T patent/ES2172698T3/es not_active Expired - Lifetime
- 1996-12-04 AT AT96942340T patent/ATE213144T1/de active
- 1996-12-04 US US09/091,696 patent/US6059913A/en not_active Expired - Lifetime
- 1996-12-04 PL PL96327602A patent/PL183410B1/pl not_active IP Right Cessation
- 1996-12-04 JP JP52246397A patent/JP3585128B2/ja not_active Expired - Fee Related
- 1996-12-04 CN CN96199114A patent/CN1130172C/zh not_active Expired - Fee Related
- 1996-12-04 HU HU0000209A patent/HU225104B1/hu not_active IP Right Cessation
- 1996-12-04 CA CA002240416A patent/CA2240416C/en not_active Expired - Fee Related
- 1996-12-04 WO PCT/EP1996/005410 patent/WO1997022315A1/de active IP Right Grant
- 1996-12-04 SK SK675-98A patent/SK282988B6/sk not_active IP Right Cessation
- 1996-12-04 DK DK96942340T patent/DK0959834T3/da active
- 1996-12-04 PT PT96942340T patent/PT959834E/pt unknown
- 1996-12-04 IL IL12461896A patent/IL124618A/en not_active IP Right Cessation
- 1996-12-04 NZ NZ324305A patent/NZ324305A/xx not_active IP Right Cessation
- 1996-12-04 EP EP96942340A patent/EP0959834B1/de not_active Expired - Lifetime
- 1996-12-19 MY MYPI96005339A patent/MY113548A/en unknown
- 1996-12-19 ZA ZA9610666A patent/ZA9610666B/xx unknown
-
1998
- 1998-06-19 NO NO19982844A patent/NO311636B1/no not_active IP Right Cessation
- 1998-06-19 MX MX9804996A patent/MX9804996A/es not_active IP Right Cessation
-
2000
- 2000-06-01 HK HK00103356A patent/HK1026356A1/xx not_active IP Right Cessation
Patent Citations (3)
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GB2237262A (en) * | 1989-10-25 | 1991-05-01 | Osaka Sealing Label Print | Manufacturing labels on a continuous web |
DE4232279C1 (de) * | 1992-09-25 | 1993-10-21 | Lohmann Therapie Syst Lts | Transferverfahren zur Herstellung transdermaler therapeutischer Systeme |
WO1995023687A1 (de) * | 1994-03-03 | 1995-09-08 | Lts Lohmann Therapie-Systeme Gmbh | Vorrichtung zur übertragung von einseitig selbstklebenden abschnitten von einer bewegten ersten bahn auf eine bewegte zweite bahn |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002530216A (ja) * | 1998-11-21 | 2002-09-17 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 扁平形態物品を給送する方法および装置 |
WO2001022946A2 (de) * | 1999-09-28 | 2001-04-05 | Lts Lohmann Therapie-Systeme Ag | Verfahren und vorrichtung zum spenden haftklebender laminatabschnitte |
DE19946384A1 (de) * | 1999-09-28 | 2001-04-05 | Lohmann Therapie Syst Lts | Verfahren und Vorrichtung zum Spenden haftklebender Laminatabschnitte von einer beweglichen primären auf eine bewegliche sekundäre Trägerbahn |
WO2001022946A3 (de) * | 1999-09-28 | 2001-11-01 | Lohmann Therapie Syst Lts | Verfahren und vorrichtung zum spenden haftklebender laminatabschnitte |
US7029549B1 (en) | 1999-09-28 | 2006-04-18 | Lts Lohmann Therapie-Systeme Ag | Method and device for dispensing adhesive laminate segments |
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