WO1996039156A3 - Phosphate-binding polymers for oral administration - Google Patents

Phosphate-binding polymers for oral administration Download PDF

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Publication number
WO1996039156A3
WO1996039156A3 PCT/US1996/008529 US9608529W WO9639156A3 WO 1996039156 A3 WO1996039156 A3 WO 1996039156A3 US 9608529 W US9608529 W US 9608529W WO 9639156 A3 WO9639156 A3 WO 9639156A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphate
oral administration
binding polymers
polymers
binding
Prior art date
Application number
PCT/US1996/008529
Other languages
French (fr)
Other versions
WO1996039156A2 (en
Inventor
Stephen Randall Holmes-Farley
W Harry Mandeville Iii
George M Whitesides
Original Assignee
Geltex Pharma Inc
Holmes Farley Stephen Randall
W Harry Mandeville Iii
George M Whitesides
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23872837&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1996039156(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geltex Pharma Inc, Holmes Farley Stephen Randall, W Harry Mandeville Iii, George M Whitesides filed Critical Geltex Pharma Inc
Priority to JP9501099A priority Critical patent/JPH11512074A/en
Priority to NZ309548A priority patent/NZ309548A/en
Priority to EP96917049A priority patent/EP0831857A2/en
Priority to AU59742/96A priority patent/AU5974296A/en
Publication of WO1996039156A2 publication Critical patent/WO1996039156A2/en
Publication of WO1996039156A3 publication Critical patent/WO1996039156A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen

Abstract

Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
PCT/US1996/008529 1995-06-06 1996-06-03 Phosphate-binding polymers for oral administration WO1996039156A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP9501099A JPH11512074A (en) 1995-06-06 1996-06-03 Phosphate scavenging polymer for oral administration
NZ309548A NZ309548A (en) 1995-06-06 1996-06-03 Use of phosphate-binding polymers for oral administration
EP96917049A EP0831857A2 (en) 1995-06-06 1996-06-03 Phosphate-binding polymers for oral administration
AU59742/96A AU5974296A (en) 1995-06-06 1996-06-03 Phosphate-binding polymers for oral administration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/471,747 1995-06-06
US08/471,747 US5667775A (en) 1993-08-11 1995-06-06 Phosphate-binding polymers for oral administration

Publications (2)

Publication Number Publication Date
WO1996039156A2 WO1996039156A2 (en) 1996-12-12
WO1996039156A3 true WO1996039156A3 (en) 1997-03-27

Family

ID=23872837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008529 WO1996039156A2 (en) 1995-06-06 1996-06-03 Phosphate-binding polymers for oral administration

Country Status (7)

Country Link
US (7) US5667775A (en)
EP (1) EP0831857A2 (en)
JP (1) JPH11512074A (en)
KR (1) KR19990022648A (en)
AU (1) AU5974296A (en)
NZ (1) NZ309548A (en)
WO (1) WO1996039156A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889738B2 (en) 2006-12-14 2014-11-18 Genzyme Corporation Amido-amine polymer compositions
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US9555056B2 (en) 2004-11-01 2017-01-31 Genzyme Corporation Aliphatic amine polymer salts for tableting

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0684958T3 (en) * 1993-02-17 1998-10-19 Btg Int Ltd Polymers containing guanidino groups for use in therapy
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6726905B1 (en) * 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
US6271264B1 (en) 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
US6361768B1 (en) 1998-12-29 2002-03-26 Pmd Holdings Corp. Hydrophilic ampholytic polymer
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
US6733780B1 (en) * 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
ES2269218T3 (en) * 1999-12-22 2007-04-01 Wisconsin Alumni Research Foundation CALCIUM FORMAT AS A FOOD SUPPLEMENT.
DE10009982A1 (en) * 2000-03-03 2001-09-06 Qiagen Gmbh New anion-exchange resin, useful particularly for isolating plasmid DNA, prepared by reacting acrylic acid derivative with specific crosslinking agent
AU2001241076A1 (en) * 2000-03-09 2001-09-17 Hisamitsu Pharmaceutical Co. Inc. Crosslinked anion-exchange resin or salt thereof
US6844372B2 (en) 2000-03-09 2005-01-18 Hisamitsu Pharmaceutical Co., Inc. Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same
US20030091530A1 (en) * 2000-03-13 2003-05-15 Takeshi Goto Preventives and/or remedies for hyperphosphatemia
RS50397B (en) * 2000-07-28 2009-12-31 F. Hoffmann-La Roche Ag., Pharmaceutical composition
DE10065710A1 (en) * 2000-12-29 2002-07-04 Bayer Ag Medicament containing a polyamine as an active substance
WO2002066543A1 (en) * 2001-02-16 2002-08-29 Genzyme Corporation Method of drying a material having a cohesive phase
EP1923064B1 (en) 2001-04-18 2017-06-28 Genzyme Corporation Use of amine polymer for lowering serum glucose
CA2444587C (en) * 2001-04-18 2008-10-21 Genzyme Corporation Pharmaceutical compositions of low salt polyallylamine hydrochloride
ES2304437T3 (en) * 2001-04-18 2008-10-16 Genzyme Corporation USE OF COLESEVELAM OR SEVELAMER HYDROCLORIDE TO REDUCE SERIOUS GLUCOSE.
JP2004526778A (en) * 2001-04-18 2004-09-02 ジェンザイム コーポレーション Method for treating X syndrome using aliphatic polyamine
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
US20050107253A1 (en) * 2001-12-21 2005-05-19 Hiroyuki Sano Adsorbent for phosphoric acid
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
WO2003080630A2 (en) * 2002-03-19 2003-10-02 Genzyme Corporation Phosphate transport inhibitors
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) * 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
US7220406B2 (en) * 2002-10-22 2007-05-22 Genzyme Corporation Method for promoting bone formation
WO2004099288A1 (en) * 2003-05-09 2004-11-18 Carlsberg A/S Polyethyleneimine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
WO2005072752A1 (en) * 2004-01-30 2005-08-11 Taisho Pharmaceutical Co., Ltd. Preventive or therapeutic agents for hyperphosphatemia
JPWO2005092349A1 (en) 2004-03-26 2008-02-07 田辺三菱製薬株式会社 Insulin resistance improving agent
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US8192758B2 (en) 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
WO2005094384A2 (en) 2004-03-30 2005-10-13 Ilypsa, Inc. Methods and compositions for treatment of ion imbalances
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
GB2456253B (en) 2004-03-30 2009-08-26 Relypsa Inc Ion binding polymers and uses thereof
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use
EP1796737B1 (en) * 2004-09-24 2018-10-24 Biosphere Medical, Inc. Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, as well as methods of use thereof
CA2583548A1 (en) * 2004-10-15 2006-04-27 Altairnano, Inc. Phosphate binder with reduced pill burden
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
EP1830832A1 (en) * 2004-12-30 2007-09-12 Genzyme Corporation Zinc-containing treatments for hyperphosphatemia
JP2008533272A (en) * 2005-03-16 2008-08-21 ユーエスヴィー リミテッド Improved method for the preparation of crosslinked polyallylamine polymers
JP2009504779A (en) * 2005-08-17 2009-02-05 アルテアナノ インコーポレイテッド Treatment of chronic renal failure and other illnesses in livestock: compositions and methods
DE06801934T1 (en) * 2005-08-17 2009-01-15 Altairnano, Inc., Reno HYPERPHOSPHATEMIA IN PETS: COMPOSITIONS AND METHODS OF TREATMENT
AR056499A1 (en) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd COMPOUNDS
BRPI0616078B8 (en) * 2005-09-15 2021-05-25 Genzyme Corp powder of an amine polymer pharmaceutical formulation, use of such powder and sachet formulation for amine polymers
AU2006299449B2 (en) * 2005-09-30 2013-07-04 Relypsa, Inc. Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
CA2624112A1 (en) * 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
CA2626734A1 (en) * 2005-11-08 2007-05-18 Genzyme Corporation Magnesium-containing polymers for the treatment of hyperphosphatemia
NZ569756A (en) * 2005-12-12 2011-07-29 Allaccem Inc Methods and systems for preparing antimicrobial films and coatings utilising polycyclic bridged ammonium salts
CA2641039C (en) * 2006-02-03 2013-08-20 Wm. Wrigley Jr. Company Calcium phosphate salts in oral compositions suitable as a tooth remineralizing agent
ITRM20060204A1 (en) 2006-04-10 2007-10-11 Vincenzo Savica PHARMACEUTICALS AND PHARMACEUTICALS FOR HYPERPROTIC HYPROPROSTICAL NORMOPROTEIC DIETS ALL HYPOPHOSPHORIC AND HYPOFOSPHORIC DRINKS
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
WO2007145308A1 (en) 2006-06-16 2007-12-21 Mitsubishi Tanabe Pharma Corporation Agent for prevention and/or treatment of glomerulopathy
JP2009542653A (en) * 2006-07-05 2009-12-03 ジェンザイム コーポレーション Iron (II) containing therapeutic agent for hyperphosphatemia
US9375499B2 (en) * 2006-07-14 2016-06-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
EP2049014A2 (en) * 2006-07-18 2009-04-22 Genzyme Corporation Amine dendrimers
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
JP2010504285A (en) * 2006-09-01 2010-02-12 ゲンズイメ コーポレーション Dendrimer composition
JP2010504975A (en) 2006-09-29 2010-02-18 ゲンズイメ コーポレーション Amide dendrimer composition
ES2522908T3 (en) 2007-02-21 2014-11-19 Allaccem, Inc. Compositions based on polycyclic bridged compounds for disease inhibition and relief
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
WO2008109095A1 (en) * 2007-03-08 2008-09-12 Genzyme Corporation Sulfone polymer compositions
CA2625522A1 (en) * 2007-04-20 2008-10-20 Rohm And Haas Company Method for removing phosphate from aqueous solutions
WO2008133954A1 (en) * 2007-04-27 2008-11-06 Genzyme Corporation Amido-amine dendrimer compositions
KR20100045965A (en) * 2007-07-11 2010-05-04 도레이 카부시키가이샤 Crosslinked polyallylamine or acid addition salt thereof, and use thereof for medical purposes
EP2016947A1 (en) * 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Novel one step process for preparing cross-linked poly(allylamine) polymers
US8153618B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
US8153617B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8188068B2 (en) * 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US20090074833A1 (en) * 2007-08-17 2009-03-19 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling bone resorption
TWI592159B (en) 2007-11-16 2017-07-21 威佛（國際）股份有限公司 Pharmaceutical compositions
US20100316589A1 (en) * 2007-12-14 2010-12-16 Hitesh Bhagat Coated Pharmaceutical Compositions
WO2009122400A1 (en) * 2008-03-31 2009-10-08 Semorex Inc. Phosphate binding polymers
WO2009125433A2 (en) * 2008-04-08 2009-10-15 Usv Limited Process for preparation of amine polymer salt
US20100004218A1 (en) * 2008-06-20 2010-01-07 Whiteford Jeffery A Bridged polycyclic compound based compositions for renal therapy
WO2009154747A1 (en) * 2008-06-20 2009-12-23 Genzyme Corporation Pharmaceutical compositions
US20100016270A1 (en) * 2008-06-20 2010-01-21 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling cholesterol levels
US8513206B2 (en) * 2008-07-29 2013-08-20 Council Of Scientific And Industrial Research Crosslinked PEI nanoparticle transfection agents for delivery of biomolecules with increased efficiency
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
KR102178208B1 (en) * 2008-08-22 2020-11-12 리립사, 인크. Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia
US8337824B2 (en) 2008-08-22 2012-12-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
US20100166861A1 (en) * 2008-12-29 2010-07-01 Kelly Noel Lynch Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone
WO2010086881A2 (en) 2009-01-22 2010-08-05 Usv Limited Pharmaceutical compositions comprising phosphate-binding polymer
BRPI1012076A2 (en) * 2009-06-16 2019-04-16 Watson Pharma Private Ltd processes for preparation of sevelamer carbonate
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
US8673272B2 (en) * 2009-07-27 2014-03-18 Isp Investments Inc. Ultraviolet-absorbing compounds
WO2011106542A2 (en) 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants
WO2011143475A1 (en) 2010-05-12 2011-11-17 Spectrum Pharmaceuticals, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
DK2672945T3 (en) 2011-02-09 2016-03-21 Synthon Bv STABILIZED PACKAGING TYPES OF sevelamer.
EP2773329B1 (en) 2011-11-04 2016-01-13 Synthon BV Pharmaceutical compositions comprising sevelamer
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom
RU2014128587A (en) 2011-12-13 2016-02-10 Синтон Б.В. GETTING A SEALAMER WITH A REDUCED ALLYLAMINE CONTENT
WO2013087237A1 (en) 2011-12-13 2013-06-20 Synthon Bv Purification of sevelamer and related polyallylamines
CN104822383A (en) 2012-10-08 2015-08-05 瑞立普萨公司 Potassium-binding agents for treating hypertension and hyperkalemia
EP2968165B1 (en) 2013-03-13 2023-09-13 Biosphere Medical, Inc. Compositions and associated methods for radioisotope-binding microparticles
CA2912911C (en) 2013-06-05 2023-10-03 Tricida, Inc. Proton-binding polymers for oral administration
EP3229816B1 (en) 2014-12-10 2020-02-05 Tricida Inc. Proton-binding polymers for oral administration
MA41202A (en) 2014-12-18 2017-10-24 Genzyme Corp CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES
EP3261624A1 (en) 2015-02-23 2018-01-03 Amneal Pharmaceuticals Company GmbH Process for granulating sevelamer carbonate
US20200054669A1 (en) 2016-05-06 2020-02-20 Tricida, Inc. Compositions for and methods of treating acid-base disorders
US10934380B1 (en) 2017-09-25 2021-03-02 Tricida, Inc. Crosslinked poly(allylamine) polymer pharmaceutical compositions
US10479865B2 (en) * 2017-11-01 2019-11-19 Strides Shasun Limited Process for the preparation of sevelamer carbonate
AU2018360867A1 (en) 2017-11-03 2020-04-30 Tricida, Inc. Compositions for and method of treating acid-base disorders
WO2023064357A1 (en) * 2021-10-13 2023-04-20 Tricida, Inc. Pharmaceutical compositions for the treatment of lithiasis disorders
EP4295836A1 (en) 2022-06-22 2023-12-27 Labomed Pharmaceutical Company S.A. Sachet comprising a liquid suspension of a sevelamer salt

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2232563A1 (en) * 1973-06-11 1975-01-03 Merck & Co Inc
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
NL7603653A (en) * 1975-04-23 1976-10-26 Merck & Co Inc METHOD OF PREPARING NEW CHOLESTEROLEMIA AGENTS.
AU480922A (en) * 1974-05-20 1977-02-15
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
EP0162388A1 (en) * 1984-05-11 1985-11-27 Bristol-Myers Company Novel bile sequestrant resin and uses
EP0375350A2 (en) * 1988-12-21 1990-06-27 Smith Kline & French Laboratories Limited Cross-linked vinylpyridinium polymers
WO1994004596A1 (en) * 1992-08-20 1994-03-03 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts
WO1994027621A1 (en) * 1993-05-20 1994-12-08 Geltex, Inc. Iron-binding polymers for oral administration
WO1995005184A2 (en) * 1993-08-11 1995-02-23 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2456428A (en) * 1944-10-11 1948-12-14 Shell Dev Polyallyl amine and related polymeric amines
BE580490A (en) 1958-07-15 1960-01-08 Merck & Co Inc Compositions and methods for lowering the cholesterol content of the blood
US3104205A (en) 1959-12-17 1963-09-17 Warner Lambert Pharmaceutical Deodorant composition comprising the copper complex of the copolymer of allylamine and methacrylic acid
US3308020A (en) 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3332841A (en) 1961-10-04 1967-07-25 Lilly Co Eli Method of treating hyperacidity
US3293195A (en) * 1963-11-29 1966-12-20 Ritter Pfaudler Corp Ion exchange resins prepared from a mixed resin of vinyl pyridine copolymers and epihalohydrins-polyalkylene polyamines and methods of making and using same
US3624209A (en) 1966-12-28 1971-11-30 Bristol Myers Co Composition for treatment of gastro-intestinal disorders
DE1927336A1 (en) 1968-06-17 1969-12-18 Upjohn Co Oral dosage form for the prevention of hypercholesterolemia
DK136015B (en) 1973-02-09 1977-08-01 Sandoz Ag Process for the preparation of an aluminum hydrogel for use as a phosphate binder.
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4181718A (en) * 1975-12-29 1980-01-01 Mason Norbert S Polyanion-stabilized aluminum hydrogels
US4183918A (en) 1977-03-08 1980-01-15 Exxon Research & Engineering Co. Detoxifying-medicinal emulsions
GB1573487A (en) 1977-05-23 1980-08-28 Bristol Myers Co Bile acid binding composition
US4143130A (en) 1977-08-29 1979-03-06 Warren-Teed Laboratories, Inc. Method for treating kidney stones
JPS5566513A (en) 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
US4247393A (en) * 1979-01-11 1981-01-27 Wallace Richard A Hemodialysis assist device
US4439419A (en) * 1980-02-20 1984-03-27 The Upjohn Company Method of treating gastric hyperacidity in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance as epichlorhydrin
US4344993A (en) 1980-09-02 1982-08-17 The Dow Chemical Company Perfluorocarbon-polymeric coatings having low critical surface tensions
ATE12511T1 (en) 1980-12-12 1985-04-15 Smith & Nephew Ass POLYMERS, THEIR PRODUCTION AND USES.
JPS5879022A (en) 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk Novel metal-crosslinked polymer compound containing quaternary nitrogen atom, its preparation, and remedy for hyperlipemia containing said polymer compound as active component
US4504640A (en) * 1982-05-19 1985-03-12 Nitto Boseki Co., Ltd. Process for producing monoallylamine polymer
JPS6090243A (en) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd Small spherical crosslinked monoallylamine polymer and its preparation
US4688988A (en) 1984-12-17 1987-08-25 United Technologies Corporation Coolable stator assembly for a gas turbine engine
US4631305A (en) 1985-03-22 1986-12-23 The Upjohn Company Polymeric material as a disintegrant in a compressed tablet
DE3541511A1 (en) * 1985-11-19 1987-05-21 Grace W R Ab PROMOTER FOR PAPER SIZING, METHOD FOR THE PRODUCTION AND USE THEREOF
JPS62132830A (en) 1985-12-05 1987-06-16 Teijin Ltd Slow-releasing medicinal drug composition
JP2503962B2 (en) 1986-03-19 1996-06-05 株式会社豊田自動織機製作所 Remaining thread bobbin take-out device of Shino-changing machine
DE68911146T2 (en) 1988-08-26 1994-04-14 Upjohn Co FINE-GRAINED COLESTIPOL HYDROCHLORIDE.
DE3901527A1 (en) 1989-01-20 1990-07-26 Hoechst Ag ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS
US6274713B1 (en) * 1989-04-07 2001-08-14 Salutar, Inc. Polychelants
US5236701A (en) 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
JPH04503962A (en) 1989-08-07 1992-07-16 ジ・アップジョン・カンパニー Microbeaded colestipol hydrochloride
US5136032A (en) * 1989-12-07 1992-08-04 Daicel Chemical Industries, Ltd. Method for separating phosphopolyol compounds using a separating agent
US5053423A (en) 1990-03-22 1991-10-01 Quadra Logic Technologies Inc. Compositions for photodynamic therapy
JPH0687974B2 (en) 1990-03-27 1994-11-09 忠一 平山 Adsorption material for heat generating substances
DE4010271A1 (en) 1990-03-30 1991-10-02 Basf Ag METHOD FOR PRODUCING ETHYLENE POLYMERISATS AT PRESSURES ABOVE 500 BAR IN A PIPE REACTOR WITH INJECTION FINGER
IE914179A1 (en) 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
US5108767A (en) 1991-06-10 1992-04-28 Abbott Laboratories Liquid nutritional product for persons receiving renal dialysis
JP2785529B2 (en) 1991-08-21 1998-08-13 日東紡績株式会社 Ethanol sustained release agent and food preservation composition using the same
EP0534304A1 (en) 1991-09-21 1993-03-31 Hoechst Aktiengesellschaft Cycloalkylated polyethylenimines and their use as hypolipemic agents
SE470006B (en) 1991-09-26 1993-10-25 Corline Systems Ab New conjugate, its preparation and use, and substrates prepared with the conjugate
DK0580078T3 (en) 1992-07-22 1998-05-25 Hoechst Ag Polyvinylamine derivatives with hydrophilic centers, process for their preparation as well as the use of the compounds as drugs, carriers of active substances and food aid.
ES2096150T3 (en) 1992-07-22 1997-03-01 Hoechst Ag LINKED VINYL COPOLYMERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THE USE OF THESE COMPOUNDS.
US5302531A (en) 1992-10-22 1994-04-12 Miles Inc. Composition for the semiquantitative determination of specific gravity of a test sample
EP0605757B1 (en) 1992-11-25 2001-08-16 Ajinomoto Co., Inc. Compositions and goods containing minerals and poly-gamma-glutamic acid
DK0684958T3 (en) 1993-02-17 1998-10-19 Btg Int Ltd Polymers containing guanidino groups for use in therapy
JPH06321786A (en) 1993-05-12 1994-11-22 Sekisui Chem Co Ltd Agent for inhibiting absorption of bile acid in enteric canal
EP0706399A4 (en) 1993-06-02 1998-08-12 Geltex Pharma Inc Compositions and process for removing bile salts
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
WO1996021454A1 (en) 1995-01-12 1996-07-18 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
GB9503061D0 (en) 1995-02-16 1995-04-05 British Tech Group Polymeric compounds
JP2936129B2 (en) 1995-04-12 1999-08-23 セイコー精機株式会社 Anti-corrosion structure
FI104823B (en) 1996-06-24 2000-04-14 Borealis Polymers Oy Anti-fouling coating
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US5985938A (en) 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
DE19835467A1 (en) 1998-08-06 2000-02-17 Elenac Gmbh Solid reactor with antistatic coating for carrying out reactions in the gas phase
US6500527B2 (en) * 2001-02-01 2002-12-31 3M Innovative Properties Company Image receptor sheet
ITMI20021718A1 (en) 2002-07-31 2004-02-01 Sematic Italia Spa SAFETY SWITCH WITH ELECTRONIC PROGRAMMABLE SYSTEM.

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
FR2232563A1 (en) * 1973-06-11 1975-01-03 Merck & Co Inc
AU480922A (en) * 1974-05-20 1977-02-15
NL7603653A (en) * 1975-04-23 1976-10-26 Merck & Co Inc METHOD OF PREPARING NEW CHOLESTEROLEMIA AGENTS.
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
EP0162388A1 (en) * 1984-05-11 1985-11-27 Bristol-Myers Company Novel bile sequestrant resin and uses
EP0375350A2 (en) * 1988-12-21 1990-06-27 Smith Kline & French Laboratories Limited Cross-linked vinylpyridinium polymers
WO1994004596A1 (en) * 1992-08-20 1994-03-03 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts
WO1994027621A1 (en) * 1993-05-20 1994-12-08 Geltex, Inc. Iron-binding polymers for oral administration
WO1995005184A2 (en) * 1993-08-11 1995-02-23 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PETRARIU, I. ET AL: "Hofmann degradation in quaternary basic ammonium polymers I. Degradation of the linear and crosslinked basic benzylic polyelectrolytes in alkaline media", XP002025288 *
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZABUTAYA, F. I. ET AL: "Proton NMR spectroscopic study of the reaction of epichlorohydrin with allylamine", XP002025287 *
MATER. PLAST. (BUCHAREST), vol. 9, no. 9, 1972, pages 467 - 72 *
SHKINEV,V.M. ET AL: "Anion exchange extraction and enrichment from aqueous solutions by quaternary ammonium reagents", SOLVENT EXTRACTION AND ION EXCHANGE, vol. 7, no. 3, 1989, pages 499 - 510, XP000617752 *
UZB. KHIM. ZH., no. 3, 1985, pages 23 - 27 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9555056B2 (en) 2004-11-01 2017-01-31 Genzyme Corporation Aliphatic amine polymer salts for tableting
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US8889738B2 (en) 2006-12-14 2014-11-18 Genzyme Corporation Amido-amine polymer compositions

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