WO1996002259A1 - Hard tissue stimulating agent - Google Patents
Hard tissue stimulating agent Download PDFInfo
- Publication number
- WO1996002259A1 WO1996002259A1 PCT/SE1995/000857 SE9500857W WO9602259A1 WO 1996002259 A1 WO1996002259 A1 WO 1996002259A1 SE 9500857 W SE9500857 W SE 9500857W WO 9602259 A1 WO9602259 A1 WO 9602259A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chitosan
- hard tissue
- agent
- heparin
- polysaccharide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ290219A NZ290219A (en) | 1994-07-19 | 1995-07-13 | Osseointegration implant and its use in regenerating hard tissue |
US08/505,353 US5894070A (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
CZ1997140A CZ289981B6 (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
MX9700443A MX9700443A (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent. |
AT95926565T ATE219678T1 (en) | 1994-07-19 | 1995-07-13 | ACTIVE SUBSTANCE FOR STIMULATION OF HARD TISSUE |
AU30895/95A AU696183C (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
BR9508322A BR9508322A (en) | 1994-07-19 | 1995-07-13 | Use of chitosan and an immobilized polysaccharide in the same process to stimulate and / or accelerate regeneration of rigid tissue and implant intended for integration into rigid tissue |
DK95926565T DK0771206T3 (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulant |
PL95318326A PL181764B1 (en) | 1994-07-19 | 1995-07-13 | Hard tissue regeneration stimulating factor |
EP95926565A EP0771206B1 (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
HU9700160A HU220770B1 (en) | 1994-07-19 | 1995-07-13 | The use of a polysaccharide applied onto chitosan for the manufacture of a composition stimulating the regeneration of hard tissue |
DE69527203T DE69527203T2 (en) | 1994-07-19 | 1995-07-13 | ACTIVE SUBSTANCE FOR STIMULATING HARD TISSUE |
JP50495596A JP3492377B2 (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulant |
CA002194462A CA2194462C (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
IS4409A IS1793B (en) | 1994-07-19 | 1997-01-06 | Use of chitosan and polysaccharide in conjunction with hard tissue regeneration, including transplantation |
NO19970215A NO310223B1 (en) | 1994-07-19 | 1997-01-17 | Use of chitosan and a polysaccharide in connection with regeneration of hard tissue, as well as implant |
FI970202A FI970202A (en) | 1994-07-19 | 1997-01-17 | Hard tissue stimulant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9402528-5 | 1994-07-19 | ||
SE9402528A SE9402528D0 (en) | 1994-07-19 | 1994-07-19 | Hard tissue stimulant with electricity |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996002259A1 true WO1996002259A1 (en) | 1996-02-01 |
Family
ID=20394768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1995/000857 WO1996002259A1 (en) | 1994-07-19 | 1995-07-13 | Hard tissue stimulating agent |
Country Status (22)
Country | Link |
---|---|
US (1) | US5894070A (en) |
EP (1) | EP0771206B1 (en) |
JP (1) | JP3492377B2 (en) |
KR (1) | KR100395724B1 (en) |
CN (1) | CN1081923C (en) |
AT (1) | ATE219678T1 (en) |
BR (1) | BR9508322A (en) |
CA (1) | CA2194462C (en) |
CZ (1) | CZ289981B6 (en) |
DE (1) | DE69527203T2 (en) |
DK (1) | DK0771206T3 (en) |
ES (1) | ES2178675T3 (en) |
FI (1) | FI970202A (en) |
HU (1) | HU220770B1 (en) |
IS (1) | IS1793B (en) |
MX (1) | MX9700443A (en) |
NO (1) | NO310223B1 (en) |
NZ (1) | NZ290219A (en) |
PL (1) | PL181764B1 (en) |
RU (1) | RU2153877C2 (en) |
SE (1) | SE9402528D0 (en) |
WO (1) | WO1996002259A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19724869A1 (en) * | 1997-06-12 | 1998-12-24 | Henkel Kgaa | Use of chitosan or chitosan derivatives for surface coating |
US5894070A (en) * | 1994-07-19 | 1999-04-13 | Astra Aktiebolag | Hard tissue stimulating agent |
US5993535A (en) * | 1997-08-28 | 1999-11-30 | Ngk Spark Plug Co., Ltd. | Calcium phosphate cement and calcium phosphate cement composition |
US6051061A (en) * | 1998-03-23 | 2000-04-18 | Ngk Spark Plug Co., Ltd. | Calcium phosphate cements and calcium phosphate cement compositions |
WO2000056275A1 (en) * | 1999-03-22 | 2000-09-28 | Virbac | Compositions based on chondroitin sulphate and chitosan for preventing or treating rheumatic disorders by general administration |
WO2002011782A1 (en) * | 2000-08-10 | 2002-02-14 | Osfarma, S.L. | Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications |
EP1512773A1 (en) * | 2003-08-15 | 2005-03-09 | MERCK PATENT GmbH | Chitosan-coated metallic device and method of preparation |
EP0984796B1 (en) * | 1997-04-26 | 2005-07-27 | Yong Chan Lee | Implantable artificial tooth coated with chitosan |
US6991802B1 (en) | 1999-09-01 | 2006-01-31 | Delsitech Oy | Multilayered material bearing a biologically active agent and the preparation thereof |
EP1744766A1 (en) * | 2004-05-07 | 2007-01-24 | The University Of Queensland | Composition for stimulating bone growth and differentiation and method for isolating same |
WO2007046775A1 (en) | 2005-10-21 | 2007-04-26 | Cellresearch Corporation Pte Ltd | Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom |
WO2007122269A1 (en) * | 2006-04-26 | 2007-11-01 | B. Braun Melsungen Ag | Manufacture and use of modified polysaccharide chitosan bonds and a process to improve the preparation of hes-medicinal substance compounds |
EP1977739A1 (en) * | 2007-04-03 | 2008-10-08 | Bioiberica, S.A. | Nanoparticulate composition of chitosan and chondroitin sulfate |
GB2463474A (en) * | 2008-09-11 | 2010-03-17 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
AU2005239977B2 (en) * | 2004-05-07 | 2010-11-11 | The University Of Queensland | Composition for stimulating bone growth and differentiation and method for isolating same |
EP2597149A1 (en) | 2004-08-16 | 2013-05-29 | CellResearch Corporation Pte Ltd | Isolation, cultivation and uses of stem/progenitor cells |
US11491178B2 (en) | 2012-01-27 | 2022-11-08 | Hoffmann-La Roche, Inc. | Chitosan covalently linked with small molecule integrin antagonist for targeted delivery |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030147860A1 (en) * | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
US6263880B1 (en) | 1998-06-22 | 2001-07-24 | Neovasys, Inc. | Method of enhancing blood flow in tissue |
EP1152013B1 (en) * | 1998-11-10 | 2008-04-23 | Netech Inc. | Functional chitosan derivative |
WO2001000792A1 (en) | 1999-06-29 | 2001-01-04 | Marchosky J Alexander | Compositions and methods for forming and strengthening bone |
GB9920393D0 (en) * | 1999-08-27 | 1999-11-03 | Medix Scient Uk Limited | Plant extract mixtures and their uses |
ES2491866T3 (en) * | 1999-11-15 | 2014-09-08 | Piramal Healthcare (Canada) Limited | Temperature-controlled, pH-dependent, self-gelling aqueous biopolymer solution |
US20030158302A1 (en) * | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
ATE243049T1 (en) * | 1999-12-09 | 2003-07-15 | Biosyntech Canada Inc | MINERAL-POLYMER HYBRID COMPOSITION |
DK1294414T3 (en) * | 2000-06-29 | 2006-07-24 | Biosyntech Canada Inc | Preparation and method of healing and regenerating cartilage and other tissues |
US20040091540A1 (en) * | 2000-11-15 | 2004-05-13 | Desrosiers Eric Andre | Method for restoring a damaged or degenerated intervertebral disc |
CA2493083C (en) * | 2002-07-16 | 2012-11-06 | Bio Syntech Canada Inc. | Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors |
US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
FR2844717B1 (en) * | 2002-09-23 | 2006-07-07 | Richard Cancel | REINFORCING PLATE COMPRISING IN PARTICULAR CHITOSAN |
CN100394989C (en) * | 2002-11-15 | 2008-06-18 | 华沙整形外科股份有限公司 | Collagen-based materials and methods for augmenting intervertebral discs |
US20040186471A1 (en) * | 2002-12-07 | 2004-09-23 | Sdgi Holdings, Inc. | Method and apparatus for intervertebral disc expansion |
WO2005065396A2 (en) * | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
US20070231788A1 (en) * | 2003-12-31 | 2007-10-04 | Keyvan Behnam | Method for In Vitro Assay of Demineralized Bone Matrix |
FR2866571B1 (en) * | 2004-02-20 | 2007-09-21 | Philippe Zanchetta | USE OF A MIXTURE OF SPECIFIC POLYSACCHARIDES AS INDICATED BY THE EZBONE INVENTOR COMPRISING HYALURONIC ACID, CHONDROID SULFATE, DERMATANE SULFATE AND HEPARIN IN BONE HEALING. |
WO2006078211A1 (en) * | 2005-01-19 | 2006-07-27 | Bonoss Medical Ab | Growth factor composition |
US8911759B2 (en) * | 2005-11-01 | 2014-12-16 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
WO2007051311A1 (en) * | 2005-11-04 | 2007-05-10 | Bio Syntech Canada Inc. | Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state |
US8399619B2 (en) * | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
US8118779B2 (en) * | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
US8642061B2 (en) * | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
US9554920B2 (en) * | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
WO2008157495A2 (en) * | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Bone matrix compositions and methods |
WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
US9492278B2 (en) * | 2007-07-10 | 2016-11-15 | Warsaw Orthopedic, Inc. | Delivery system |
US20110054408A1 (en) * | 2007-07-10 | 2011-03-03 | Guobao Wei | Delivery systems, devices, tools, and methods of use |
ES2446544T3 (en) | 2007-10-19 | 2014-03-10 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
US9101475B2 (en) * | 2009-02-12 | 2015-08-11 | Warsaw Orthopedic, Inc. | Segmented delivery system |
EP3569262A1 (en) | 2013-03-14 | 2019-11-20 | Tricol Biomedical, Inc. | Biocompatible and bioabsorbable derivatized chitosan compositions |
CN105126165B (en) * | 2015-01-21 | 2017-12-08 | 中国人民解放军第三〇七医院 | A kind of titanium dental implant material and preparation method and application |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL163522B (en) * | 1970-07-20 | 1980-04-15 | Montedison Spa | PROCESS FOR PREPARING A CATALYST FOR THE POLYMERIZATION OF OLEFINS-1. |
US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5256447A (en) * | 1991-12-31 | 1993-10-26 | Minnesota Mining And Manufacturing Company | Adhesive composition and method |
CA2117347A1 (en) * | 1991-12-31 | 1993-07-08 | Joel D. Oxman | Metal filled adhesive composition and method |
SE9402528D0 (en) * | 1994-07-19 | 1994-07-19 | Astra Ab | Hard tissue stimulant with electricity |
-
1994
- 1994-07-19 SE SE9402528A patent/SE9402528D0/en unknown
-
1995
- 1995-07-13 RU RU97102352/14A patent/RU2153877C2/en active
- 1995-07-13 BR BR9508322A patent/BR9508322A/en not_active Application Discontinuation
- 1995-07-13 DE DE69527203T patent/DE69527203T2/en not_active Expired - Lifetime
- 1995-07-13 CZ CZ1997140A patent/CZ289981B6/en not_active IP Right Cessation
- 1995-07-13 NZ NZ290219A patent/NZ290219A/en unknown
- 1995-07-13 PL PL95318326A patent/PL181764B1/en unknown
- 1995-07-13 CA CA002194462A patent/CA2194462C/en not_active Expired - Fee Related
- 1995-07-13 KR KR1019970700338A patent/KR100395724B1/en not_active IP Right Cessation
- 1995-07-13 US US08/505,353 patent/US5894070A/en not_active Expired - Lifetime
- 1995-07-13 EP EP95926565A patent/EP0771206B1/en not_active Expired - Lifetime
- 1995-07-13 ES ES95926565T patent/ES2178675T3/en not_active Expired - Lifetime
- 1995-07-13 CN CN95195024A patent/CN1081923C/en not_active Expired - Fee Related
- 1995-07-13 HU HU9700160A patent/HU220770B1/en not_active IP Right Cessation
- 1995-07-13 WO PCT/SE1995/000857 patent/WO1996002259A1/en active IP Right Grant
- 1995-07-13 AT AT95926565T patent/ATE219678T1/en active
- 1995-07-13 MX MX9700443A patent/MX9700443A/en unknown
- 1995-07-13 DK DK95926565T patent/DK0771206T3/en active
- 1995-07-13 JP JP50495596A patent/JP3492377B2/en not_active Expired - Fee Related
-
1997
- 1997-01-06 IS IS4409A patent/IS1793B/en unknown
- 1997-01-17 NO NO19970215A patent/NO310223B1/en unknown
- 1997-01-17 FI FI970202A patent/FI970202A/en unknown
Non-Patent Citations (2)
Title |
---|
BIOMATERIALS, Volume 14, No. 12, 1993, R.A.A. MUZZARELLI et al., "Osteoconductive Properties of Methylpyrrolidinone Chitosan in an Animal Model", page 928. * |
SWEDISH DENTAL JOURNAL/SUPPLEMENT, Volume 64, 1989, L. PETER NILSSON, "Effects of Hyperbaric Oxygen Treatment of Bone Healing", pages 19-25. * |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5894070A (en) * | 1994-07-19 | 1999-04-13 | Astra Aktiebolag | Hard tissue stimulating agent |
EP0984796B1 (en) * | 1997-04-26 | 2005-07-27 | Yong Chan Lee | Implantable artificial tooth coated with chitosan |
DE19724869C2 (en) * | 1997-06-12 | 1999-05-12 | Henkel Kgaa | Use of citosan derivatives for surface coating |
DE19724869A1 (en) * | 1997-06-12 | 1998-12-24 | Henkel Kgaa | Use of chitosan or chitosan derivatives for surface coating |
US5993535A (en) * | 1997-08-28 | 1999-11-30 | Ngk Spark Plug Co., Ltd. | Calcium phosphate cement and calcium phosphate cement composition |
US6051061A (en) * | 1998-03-23 | 2000-04-18 | Ngk Spark Plug Co., Ltd. | Calcium phosphate cements and calcium phosphate cement compositions |
FR2791262A1 (en) * | 1999-03-22 | 2000-09-29 | Virbac Sa | COMPOSITIONS BASED ON CHONDROITINE AND CHITOSAN FOR THE PROTECTION, TREATMENT OR REPLACEMENT OF CONNECTIVE TISSUES |
US6599888B1 (en) | 1999-03-22 | 2003-07-29 | Virbac | Chondroitin sulphate and chitosan compositions for treating rheumatic disorders |
AU767689B2 (en) * | 1999-03-22 | 2003-11-20 | Virbac, Inc | Compositions based on chondroitin sulphate and chitosan for preventing or treating rheumatic disorders by general administration |
WO2000056275A1 (en) * | 1999-03-22 | 2000-09-28 | Virbac | Compositions based on chondroitin sulphate and chitosan for preventing or treating rheumatic disorders by general administration |
US6991802B1 (en) | 1999-09-01 | 2006-01-31 | Delsitech Oy | Multilayered material bearing a biologically active agent and the preparation thereof |
WO2002011782A1 (en) * | 2000-08-10 | 2002-02-14 | Osfarma, S.L. | Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications |
ES2169681A1 (en) * | 2000-08-10 | 2002-07-01 | Osfarma S L | Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications |
EP1512773A1 (en) * | 2003-08-15 | 2005-03-09 | MERCK PATENT GmbH | Chitosan-coated metallic device and method of preparation |
EP1744766A1 (en) * | 2004-05-07 | 2007-01-24 | The University Of Queensland | Composition for stimulating bone growth and differentiation and method for isolating same |
EP1744766A4 (en) * | 2004-05-07 | 2008-08-20 | Univ Queensland | Composition for stimulating bone growth and differentiation and method for isolating same |
AU2005239977B2 (en) * | 2004-05-07 | 2010-11-11 | The University Of Queensland | Composition for stimulating bone growth and differentiation and method for isolating same |
EP2597149A1 (en) | 2004-08-16 | 2013-05-29 | CellResearch Corporation Pte Ltd | Isolation, cultivation and uses of stem/progenitor cells |
US10363275B2 (en) | 2004-08-16 | 2019-07-30 | Cellresearch Corporation Pte Ltd | Isolation, cultivation and uses of stem/progenitor cells |
US9737568B2 (en) | 2004-08-16 | 2017-08-22 | Cellresearch Corporation Pte Ltd | Isolation, cultivation and uses of stem/progenitor cells |
US9085755B2 (en) | 2004-08-16 | 2015-07-21 | Cellresearch Corporation Pte Ltd. | Isolation, cultivation and uses of stem/progenitor cells |
WO2007046775A1 (en) | 2005-10-21 | 2007-04-26 | Cellresearch Corporation Pte Ltd | Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom |
US10066209B2 (en) | 2005-10-21 | 2018-09-04 | Cellresearch Corporation Pte Ltd. | Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom |
US8287854B2 (en) | 2005-10-21 | 2012-10-16 | Cellresearch Corporation Pte Ltd | Skin equivalents derived from umbilical cord mesenchymal stem/progenitor cells and umbilical cord epithelial stem/progenitor cells |
WO2007122269A1 (en) * | 2006-04-26 | 2007-11-01 | B. Braun Melsungen Ag | Manufacture and use of modified polysaccharide chitosan bonds and a process to improve the preparation of hes-medicinal substance compounds |
US8859724B2 (en) | 2006-04-26 | 2014-10-14 | B. Braun Melsungen Ag | Manufacture and use of modified polysaccharide chitosan bonds and a process to improve the preparation of HES-medicinal substance compounds |
EP1977739A1 (en) * | 2007-04-03 | 2008-10-08 | Bioiberica, S.A. | Nanoparticulate composition of chitosan and chondroitin sulfate |
WO2008119824A1 (en) * | 2007-04-03 | 2008-10-09 | Bioiberica, S.A. | Nanoparticulate composition of chitosan and chondroitin sulfate |
GB2463474B (en) * | 2008-09-11 | 2012-05-02 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
US9205106B2 (en) | 2008-09-11 | 2015-12-08 | Agency For Science, Technology And Research | Therapeutic bone growth and regeneration |
GB2463474A (en) * | 2008-09-11 | 2010-03-17 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
US11491178B2 (en) | 2012-01-27 | 2022-11-08 | Hoffmann-La Roche, Inc. | Chitosan covalently linked with small molecule integrin antagonist for targeted delivery |
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