WO1995026673A3 - Apparatus and method for imaging diseased tissue using integrated autofluorescence - Google Patents

Apparatus and method for imaging diseased tissue using integrated autofluorescence Download PDF

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Publication number
WO1995026673A3
WO1995026673A3 PCT/CA1995/000171 CA9500171W WO9526673A3 WO 1995026673 A3 WO1995026673 A3 WO 1995026673A3 CA 9500171 W CA9500171 W CA 9500171W WO 9526673 A3 WO9526673 A3 WO 9526673A3
Authority
WO
WIPO (PCT)
Prior art keywords
image
light
autofluorescence
tissue
remittance
Prior art date
Application number
PCT/CA1995/000171
Other languages
French (fr)
Other versions
WO1995026673A2 (en
Inventor
Branko Palcic
Calum Macaulay
Stephen Lam
Bruno Jaggi
Original Assignee
Xillix Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xillix Technologies Corp filed Critical Xillix Technologies Corp
Priority to JP52531795A priority Critical patent/JP3683271B2/en
Priority to EP95912989A priority patent/EP0752825B1/en
Priority to DE69518915T priority patent/DE69518915T2/en
Publication of WO1995026673A2 publication Critical patent/WO1995026673A2/en
Publication of WO1995026673A3 publication Critical patent/WO1995026673A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/555—Constructional details for picking-up images in sites, inaccessible due to their dimensions or hazardous conditions, e.g. endoscopes or borescopes

Abstract

An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.
PCT/CA1995/000171 1994-03-28 1995-03-24 Apparatus and method for imaging diseased tissue using integrated autofluorescence WO1995026673A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52531795A JP3683271B2 (en) 1994-03-28 1995-03-24 Apparatus and method for imaging an image of diseased tissue using integrated internal fluorescence
EP95912989A EP0752825B1 (en) 1994-03-28 1995-03-24 Apparatus and method for imaging diseased tissue using integrated autofluorescence
DE69518915T DE69518915T2 (en) 1994-03-28 1995-03-24 METHOD AND DEVICE FOR THE IMAGING OF DISEASED TISSUE USING THE INTEGRATED AUTOFLUORESCENCE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/218,662 1994-03-28
US08/218,662 US5590660A (en) 1994-03-28 1994-03-28 Apparatus and method for imaging diseased tissue using integrated autofluorescence

Publications (2)

Publication Number Publication Date
WO1995026673A2 WO1995026673A2 (en) 1995-10-12
WO1995026673A3 true WO1995026673A3 (en) 1995-11-23

Family

ID=22815983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000171 WO1995026673A2 (en) 1994-03-28 1995-03-24 Apparatus and method for imaging diseased tissue using integrated autofluorescence

Country Status (5)

Country Link
US (2) US5590660A (en)
EP (3) EP0752825B1 (en)
JP (3) JP3683271B2 (en)
DE (3) DE69535270T2 (en)
WO (1) WO1995026673A2 (en)

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WO1995026673A2 (en) 1995-10-12
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US5590660A (en) 1997-01-07
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DE69535270T2 (en) 2007-04-19
DE69534388T2 (en) 2006-05-24
DE69518915T2 (en) 2001-04-19
DE69535270D1 (en) 2006-11-23
JP3683271B2 (en) 2005-08-17
JP2004154592A (en) 2004-06-03
EP0920831A1 (en) 1999-06-09
JP3694667B2 (en) 2005-09-14
EP1472972A1 (en) 2004-11-03
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US5827190A (en) 1998-10-27
JPH10500588A (en) 1998-01-20

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