WO1995016035A3 - Bmp-12, bmp-13 and tendon-inducing compositions thereof - Google Patents
Bmp-12, bmp-13 and tendon-inducing compositions thereof Download PDFInfo
- Publication number
- WO1995016035A3 WO1995016035A3 PCT/US1994/014030 US9414030W WO9516035A3 WO 1995016035 A3 WO1995016035 A3 WO 1995016035A3 US 9414030 W US9414030 W US 9414030W WO 9516035 A3 WO9516035 A3 WO 9516035A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bmp
- tendon
- compositions
- inducing compositions
- ligament
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/386—Ligaments, tendons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2176942A CA2176942C (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
AU13013/95A AU689184B2 (en) | 1993-12-07 | 1994-12-06 | BMP-12, BMP-13 and tendon-inducing compositions thereof |
JP51629395A JP3717930B2 (en) | 1993-12-07 | 1994-12-06 | BMP-12, BMP-13 and their tendon-derived compositions |
KR1019960703014A KR100249923B1 (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
EP95904255A EP0733109B9 (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
DE69434651T DE69434651T2 (en) | 1993-12-07 | 1994-12-06 | BMP-12, BMP-13 AND THESE INCLUDING SEWNE-INDUCTIVE COMPOSITIONS |
NO19962304A NO317801B1 (en) | 1993-12-07 | 1996-06-04 | DNA molecule, chimeric DNA molecule or vector encoding BMP12 or BMP12 related proteins, and host cells, methods, proteins, compositions and use thereof. |
FI962350A FI119816B (en) | 1993-12-07 | 1996-06-06 | Isolated DNA sequences encoding BMP-12 or BMP-13 protein that induce tendon / ligament-like tissue formation and their applications |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16410393A | 1993-12-07 | 1993-12-07 | |
US08/164,103 | 1993-12-07 | ||
US21778094A | 1994-03-25 | 1994-03-25 | |
US08/217,780 | 1994-03-25 | ||
US08/333,576 | 1994-11-02 | ||
US08/333,576 US6027919A (en) | 1993-12-07 | 1994-11-02 | BMP-12 and BMP-13 proteins and DNA encoding them |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1995016035A2 WO1995016035A2 (en) | 1995-06-15 |
WO1995016035A3 true WO1995016035A3 (en) | 1995-07-13 |
WO1995016035A9 WO1995016035A9 (en) | 1995-09-14 |
Family
ID=27388970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/014030 WO1995016035A2 (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
Country Status (15)
Country | Link |
---|---|
US (5) | US5658882A (en) |
EP (1) | EP0733109B9 (en) |
JP (3) | JP3717930B2 (en) |
KR (1) | KR100353182B1 (en) |
AT (1) | ATE319823T1 (en) |
AU (1) | AU689184B2 (en) |
CA (1) | CA2176942C (en) |
DE (1) | DE69434651T2 (en) |
DK (1) | DK0733109T3 (en) |
ES (1) | ES2255059T3 (en) |
FI (1) | FI119816B (en) |
NO (1) | NO317801B1 (en) |
OA (1) | OA10582A (en) |
PT (1) | PT733109E (en) |
WO (1) | WO1995016035A2 (en) |
Cited By (6)
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---|---|---|---|---|
USRE41286E1 (en) | 1997-08-14 | 2010-04-27 | Zimmer Orthobiologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
US7763270B2 (en) | 2002-09-10 | 2010-07-27 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
US8546334B2 (en) | 2001-11-19 | 2013-10-01 | Scil Technology Gmbh | Device having osteoinductive and osteoconductive properties |
US8870954B2 (en) | 2008-09-09 | 2014-10-28 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US9545377B2 (en) | 2004-10-14 | 2017-01-17 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
Families Citing this family (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US20070166353A1 (en) * | 1988-04-08 | 2007-07-19 | Stryker Corporation | Osteogenic proteins |
US20080070842A1 (en) * | 1991-11-04 | 2008-03-20 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
WO1993009229A1 (en) | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
DE19525416A1 (en) * | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Use of MP52 for the treatment and prevention of diseases of the nervous system |
US20080233170A1 (en) * | 1992-02-21 | 2008-09-25 | Stryker Corporation | Osteogenic Proteins |
JPH09503904A (en) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | Growth differentiation factor-7 |
AU697625B2 (en) * | 1993-07-09 | 1998-10-15 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-6 |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
PT733109E (en) * | 1993-12-07 | 2006-07-31 | Genetics Inst Llc | MORPHOGENETIC PROTEINS OF 0SS0S PMO-12 AND PMO-13 AND THEIR COMPOSITIONS FOR TENDAO INDUCTION |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
US20010011131A1 (en) * | 1997-07-28 | 2001-08-02 | Luyten Frank P. | DNA molecules encoding cartilage-derived morphogenetic proteins |
AU1120295A (en) * | 1994-11-07 | 1996-05-31 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Cartilage-derived morphogenetic proteins |
US5846770A (en) * | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
DK0955313T3 (en) * | 1995-04-19 | 2006-08-21 | Bioph Biotech Entw Pharm Gmbh | New protein and process for making the same |
ES2203701T3 (en) * | 1995-06-05 | 2004-04-16 | Genetics Institute, Llc | USE OF BONE MORPHOGENIC PROTEINS TO HEAL AND REPAIR CONJUNCTIVE FABRIC UNIONS. |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
ZA966489B (en) * | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US7026292B1 (en) | 1995-12-12 | 2006-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
DE19548476A1 (en) * | 1995-12-22 | 1997-06-26 | Bioph Biotech Entw Pharm Gmbh | Targeted connections with cartilage and / or bone inducing activity |
US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
JPH11335398A (en) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | New monomeric protein having bone-inducing activity and preventive/therapeutic agent for chondropathy/ osteopathy consisting thereof |
EP1074620A1 (en) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
US6281195B1 (en) | 1997-02-07 | 2001-08-28 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US6235316B1 (en) * | 1997-04-04 | 2001-05-22 | Barnes-Jewish Hospital | Neocartilage and methods of use |
EP2309261A1 (en) | 1997-05-30 | 2011-04-13 | Stryker Corporation | Methods for evaluating tissue morphogenesis and morphogenic activity |
US6482584B1 (en) | 1998-11-13 | 2002-11-19 | Regeneration Technologies, Inc. | Cyclic implant perfusion cleaning and passivation process |
US20010031254A1 (en) * | 1998-11-13 | 2001-10-18 | Bianchi John R. | Assembled implant |
US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
US20020052026A1 (en) | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
AU752816B2 (en) | 1997-11-28 | 2002-10-03 | Curis, Inc. | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6027917A (en) * | 1997-12-10 | 2000-02-22 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-17 and BMP-18 compositions |
ES2389387T3 (en) | 1998-03-17 | 2012-10-25 | Genentech, Inc. | Homologous VEGF and BMP1 polypeptides |
US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
US6541623B1 (en) | 1998-04-03 | 2003-04-01 | Hyseq, Inc. | Interleukin—1 receptor antagonist and uses thereof |
US6426191B1 (en) | 1998-04-03 | 2002-07-30 | Hyseq, Inc. | Assays involving an IL-1 receptor antagonist |
US6294655B1 (en) | 1998-04-03 | 2001-09-25 | Hyseq, Inc. | Anti-interleukin-1 receptor antagonist antibodies and uses thereof |
US6958149B2 (en) | 1998-10-06 | 2005-10-25 | Stryker Corporation | Repair of larynx, trachea, and other fibrocartilaginous tissues |
US7572440B2 (en) | 1999-07-30 | 2009-08-11 | Stryker Corporation | Method for repairing a defect in an intervertebral disc |
EP1649865B1 (en) * | 1998-10-06 | 2012-06-13 | Stryker Corporation | GDF-5 for use in repairing a nonarticular cartilage defect in an intervertebral disc |
CA2343698C (en) * | 1998-10-06 | 2014-05-20 | Stryker Corporation | Repair of larynx, trachea, and other fibrocartilaginous tissues |
US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
EP2128260A3 (en) | 1998-10-07 | 2010-06-16 | STRYKER CORPORATION (a Michigan corporation) | Modified TGF-beta superfamily proteins |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
ATE255920T1 (en) * | 1999-02-01 | 2003-12-15 | Genetics Inst Llc | METHODS AND COMPOSITIONS FOR HEALING AND REPAIRING ARTicular cartilage |
JP4828703B2 (en) | 1999-04-28 | 2011-11-30 | ジェネティックス インスティテュート エルエルシー | Human GIL-19 / AE289 protein and polynucleotide encoding the same |
DK1054018T3 (en) | 1999-05-18 | 2009-05-18 | Dyax Corp | Fab fragment libraries and method of using them |
DK1223990T3 (en) * | 1999-10-15 | 2004-11-29 | Inst Genetics Llc | Formulations of hyaluronic acid for delivery of osteogenic proteins |
US6368787B1 (en) | 1999-12-16 | 2002-04-09 | Stryker Corporation | Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements |
ATE460951T1 (en) | 2000-01-25 | 2010-04-15 | Edwards Lifesciences Corp | RELEASE SYSTEMS FOR THE TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA |
AU2001245461A1 (en) * | 2000-03-09 | 2001-09-17 | Sulzer Biologics, Inc. | Product and method for biological anchoring of connective tissue to bone |
US20030065140A1 (en) * | 2000-04-03 | 2003-04-03 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
CA2648046A1 (en) | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
EP2275549A1 (en) | 2000-06-23 | 2011-01-19 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
US7270730B2 (en) * | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
US7067046B2 (en) | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
US20040010118A1 (en) * | 2000-08-16 | 2004-01-15 | Zerhusen Bryan D. | Novel proteins and nucleic acids encoding same |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
CA2441588A1 (en) * | 2001-03-23 | 2002-10-03 | Biopharm Gesellschaft Zue Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of cytokines of the tgf-.beta. superfamily for the treatment and diagnosis of skin related disorders |
DK1399023T3 (en) * | 2001-06-01 | 2008-08-18 | Wyeth Corp | Compositions for systemic administration of sequences encoding bone morphogenesis proteins |
TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
US20030087274A1 (en) * | 2001-07-05 | 2003-05-08 | Anderson David W. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
CH695985A5 (en) * | 2002-01-21 | 2006-11-15 | Straumann Holding Ag | Surface-modified implants. |
WO2003099992A2 (en) * | 2002-05-17 | 2003-12-04 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
WO2004014940A2 (en) * | 2002-08-13 | 2004-02-19 | Wyeth | PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR ß PROTEINS |
ATE554108T1 (en) | 2003-07-25 | 2012-05-15 | Amgen Inc | PROCEDURES REGARDING LDCAM AND CRTAM |
ATE357244T1 (en) | 2003-09-12 | 2007-04-15 | Wyeth Corp | INJECTABLE SOLID CALCIUM PHOSPHATE RODS FOR DELIVERY OF OSTEOGENIC PROTEINS |
EP1701729B1 (en) * | 2003-12-31 | 2018-05-02 | Warsaw Orthopedic, Inc. | Improved bone matrix compositions and methods |
US7767221B2 (en) * | 2004-03-05 | 2010-08-03 | The Trustees Of Columbia University In The City Of New York | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone |
ES2350939T3 (en) | 2004-03-10 | 2011-01-28 | Scil Technology Gmbh | COVERED IMPLANTS, THEIR MANUFACTURE AND USE OF THE SAME. |
WO2005116052A2 (en) | 2004-04-27 | 2005-12-08 | Research Development Foundation | ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING |
WO2005115438A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
JP2008511405A (en) * | 2004-08-30 | 2008-04-17 | アリーン、ネビル | Methods of using grafts for treatment of ligaments and tendons |
US8398638B2 (en) | 2004-08-30 | 2013-03-19 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
AU2006226941A1 (en) * | 2005-03-24 | 2006-09-28 | Wyeth | Use of fibrous tissue inducing proteins for hernia repair |
BRPI0609504A2 (en) * | 2005-03-30 | 2010-04-13 | Wyeth Corp | methods to stimulate hair growth by administering bone morphogenetic proteins (bmps) |
US20060247790A1 (en) * | 2005-04-30 | 2006-11-02 | Mckay William F | Shaped osteochondral grafts and methods of using same |
US20060287676A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use |
US20060286289A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intraoperative coating therapeutic agents onto sutures |
US20060287675A1 (en) * | 2005-06-15 | 2006-12-21 | Prajapati Rita T | Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use |
US20060286171A1 (en) * | 2005-06-17 | 2006-12-21 | Tianhong Zhou | Bone morphogenetic protein formulations |
WO2007052096A2 (en) * | 2005-06-29 | 2007-05-10 | Cameron Malcolm Lang Clokie | Production of bone morphogenic proteins (bmps) in transgenic mammals |
CA2627907C (en) | 2005-11-01 | 2014-06-17 | Osteotech, Inc. | Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier |
CA2627370C (en) * | 2005-11-18 | 2016-02-23 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | High activity growth factor mutants |
US8147860B2 (en) | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
EP2311505B1 (en) | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
WO2007142818A2 (en) | 2006-05-17 | 2007-12-13 | Stryker Corporation | Use of a soluble morphogenic protein complex for treating cartilage defects |
AU2007269712B2 (en) | 2006-06-30 | 2013-02-07 | Biomimetic Therapeutics, Llc | PDGF-biomatrix compositions and methods for treating rotator cuff injuries |
US8524265B2 (en) | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
US20100047309A1 (en) * | 2006-12-06 | 2010-02-25 | Lu Helen H | Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
EP2120859B1 (en) | 2006-12-21 | 2013-11-20 | Stryker Corporation | Sustained-release formulations comprising bmp-7 crystals |
US8753391B2 (en) | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
CA2688232A1 (en) * | 2007-05-25 | 2008-12-04 | Induce Biologics Inc. | A method of enhancing recombinant protein production |
US20080299172A1 (en) * | 2007-06-04 | 2008-12-04 | Stuart Young | Tissue repair implant |
AU2008265852B2 (en) | 2007-06-15 | 2014-04-17 | Warsaw Orthopedic, Inc. | Method of treating tissue |
CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
US9358113B2 (en) | 2007-07-10 | 2016-06-07 | Warsaw Orthopedic, Inc. | Delivery system |
EP2019117A1 (en) * | 2007-07-27 | 2009-01-28 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Optimized purification process of recombinant growth factor protein |
WO2009020744A1 (en) | 2007-08-07 | 2009-02-12 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations comprising gdf-5 in aqueous acidic solution |
ES2446544T3 (en) * | 2007-10-19 | 2014-03-10 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
WO2009102966A2 (en) | 2008-02-13 | 2009-08-20 | Keith Hruska | Method of treating vascular sclerosis |
US20100010549A1 (en) * | 2008-03-05 | 2010-01-14 | Neville Alleyne | device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries |
US20100004700A1 (en) * | 2008-03-05 | 2010-01-07 | Neville Alleyne | Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres |
US8469961B2 (en) * | 2008-03-05 | 2013-06-25 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
WO2009129101A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
EP2300610A1 (en) * | 2008-06-09 | 2011-03-30 | Wyeth LLC | Novel bmp-12-related proteins and methods of their manufacture |
CA2752157A1 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease |
CN102369017A (en) | 2009-02-12 | 2012-03-07 | 史赛克公司 | Compositions and methods for minimally invasive systemic delivery of proteins comprising TGF-beta superfamily members |
WO2010093950A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery system cartridge |
WO2010110974A1 (en) | 2009-03-24 | 2010-09-30 | Stryker Corporation | Methods and compositions for tissue engineering |
US8609127B2 (en) | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
WO2011031856A1 (en) | 2009-09-09 | 2011-03-17 | Stryker Corporation | Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint |
CA2774024A1 (en) | 2009-09-17 | 2011-03-24 | Stryker Corporation | Buffers for controlling the ph of bone morphogenetic proteins |
US8657859B2 (en) * | 2009-12-16 | 2014-02-25 | Advanced Veterinary Solutions | Implant for promoting stability of the canine stifle joint |
JP2013514811A (en) | 2009-12-22 | 2013-05-02 | ストライカー コーポレイション | BMP-7 mutant with reduced immunogenicity |
CN102811622A (en) | 2010-02-22 | 2012-12-05 | 生物模拟治疗公司 | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
JP5837930B2 (en) | 2010-07-30 | 2015-12-24 | ビオファーム・ゲゼルシャフト・ツァ・ビオテヒノロジッシェン・エントヴィックルング・フォン・ファルマカ・エムベーハー | Pharmaceutical delivery device and growth factor formulation for accelerating wound healing |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
EP2602264A1 (en) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
EP2983643A4 (en) | 2013-04-12 | 2016-12-28 | Univ Columbia | Methods for host cell homing and dental pulp regeneration |
CA2973727A1 (en) | 2015-01-16 | 2016-07-21 | Spineovations, Inc. | Method of treating spinal disk |
JP7025021B2 (en) | 2015-10-26 | 2022-02-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Reduced and oxidized polysaccharides and methods of their use |
KR101659796B1 (en) | 2016-01-13 | 2016-10-10 | 주식회사 셀루메드 | Mixture of bmp proteins at specific ratios |
US20190328792A1 (en) * | 2017-01-11 | 2019-10-31 | Paracelsus Medizinische Privatuniversität Salzburg - Privatstiftung | Mesenchymal stem cell-derived extracellular vesicles and their medical use |
AU2020403846A1 (en) | 2019-12-18 | 2022-08-11 | Merck Patent Gmbh | Use of the GDF-5 mutant for the treatment of pain and cartilage destruction |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991018047A2 (en) * | 1990-05-24 | 1991-11-28 | Genentech, Inc. | Mammalian expression of the bmp-2 family |
WO1993000432A1 (en) * | 1991-06-25 | 1993-01-07 | Genetics Institute, Inc. | Bmp-9 compositions |
WO1993016099A2 (en) * | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
Family Cites Families (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2465357A (en) | 1944-08-14 | 1949-03-29 | Upjohn Co | Therapeutic sponge and method of making |
CH563767A5 (en) | 1973-01-30 | 1975-07-15 | Pheulpin Jean | |
US4468464A (en) | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
DE2657370C2 (en) | 1976-12-17 | 1982-11-11 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Means for covering and / or filling in bone defects |
DE2732848A1 (en) | 1977-07-18 | 1979-02-08 | Schering Ag | DIURETHANE, HERBICIDAL AGENTS CONTAINING THESE COMPOUNDS AND THE PROCESS FOR THEIR PRODUCTION |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
US4761471A (en) * | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4727028A (en) | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4474181A (en) | 1982-02-18 | 1984-10-02 | Schenck Robert R | Method and apparatus for anastomosing small blood vessels |
US4455526A (en) * | 1982-06-29 | 1984-06-19 | The United States Of America As Represented By The Secretary Of The Air Force | FET Switching regulator |
DE3382562D1 (en) | 1982-09-24 | 1992-06-25 | Us Health | ANIMAL TISSUE RECOVERY. |
IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
GB8334498D0 (en) | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4804744A (en) * | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
US4608199A (en) | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
US4662884A (en) | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
US4596574A (en) | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
CA1341617C (en) | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
US4868161A (en) | 1984-06-29 | 1989-09-19 | City Of Hope | Method for promoting nerve regeneration |
US4627982A (en) * | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
ATE128715T1 (en) * | 1984-07-16 | 1995-10-15 | Celtrix Pharma | POLYPEPTIDE-INDUCING FACTORS IN BONE AND CARTILAGE. |
US4843063A (en) | 1984-07-16 | 1989-06-27 | Collagen Corporation | Polypeptide cartilage-inducing factors found in bone |
ATE78515T1 (en) | 1984-10-05 | 1992-08-15 | Genentech Inc | DNA, CELL CULTURES AND METHODS FOR HETEROLOGOUS PROTEIN SECRETION AND PERIPLASMIC PROTEIN RECOVERY. |
US4769328A (en) | 1984-10-12 | 1988-09-06 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in yeast |
US5187263A (en) | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
AU598455B2 (en) | 1984-12-27 | 1990-06-28 | Suntory Limited | Method for purifying an interferon |
US4886747A (en) | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
US4681763A (en) | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
US5215893A (en) | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US4798885A (en) | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
US5089396A (en) | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
US4758233A (en) | 1986-04-22 | 1988-07-19 | N.J. Phillips TPY. Limited | Cream applicator |
NL8601328A (en) | 1986-05-23 | 1987-12-16 | Langen Research | DEVICE FOR INJECTING MEAT WITH A MASS, PARTICULARLY PASTY MASS. |
US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
US4877864A (en) * | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
US5459047A (en) * | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
ZA874681B (en) * | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
US5631142A (en) * | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US6432919B1 (en) * | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
US5019087A (en) | 1986-10-06 | 1991-05-28 | American Biomaterials Corporation | Nerve regeneration conduit |
US5124316A (en) | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US5041538A (en) | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
US5202120A (en) | 1987-09-11 | 1993-04-13 | Case Western Reserve University | Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
US5147399A (en) | 1988-02-01 | 1992-09-15 | Dellon Arnold L | Method of treating nerve defects through use of a bioabsorbable surgical device |
EP0336760A3 (en) * | 1988-04-06 | 1991-03-13 | Celtrix Pharmaceuticals, Inc. | Bone-inducing protein |
US6586388B2 (en) * | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US5108753A (en) | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
US4968590A (en) * | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
US5258494A (en) | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
US5024841A (en) | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5071834A (en) | 1988-09-16 | 1991-12-10 | Genentech, Inc. | Purified activin B composition |
US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
US4955892A (en) | 1988-10-24 | 1990-09-11 | Louisiana State University | Neural cell adhesion protein nerve prosthesis |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US5011486A (en) | 1988-11-18 | 1991-04-30 | Brown University Research Foundation | Composite nerve guidance channels |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US4920962A (en) | 1988-11-23 | 1990-05-01 | Claude Proulx | Splint-like element for use in end-to-end nerve suture |
US5217867A (en) | 1988-11-30 | 1993-06-08 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
US4963146A (en) | 1989-04-20 | 1990-10-16 | Colla-Tec Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration |
US5026381A (en) | 1989-04-20 | 1991-06-25 | Colla-Tec, Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
CA2017466A1 (en) * | 1989-06-02 | 1990-12-02 | Michael C. Kiefer | Bone calcification factor |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
WO1991000103A1 (en) | 1989-06-29 | 1991-01-10 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1 |
CA2020729A1 (en) * | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5422340A (en) * | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
CA2024629C (en) * | 1989-09-06 | 2001-07-24 | Taiheiyo Cement Corporation | Xenopus laevis bone morphogenic protein, dna encoding same and use thereof |
US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5166190A (en) | 1990-01-08 | 1992-11-24 | Genentech, Inc. | Method for increasing fertility in males |
US5256418A (en) | 1990-04-06 | 1993-10-26 | Organogenesis, Inc. | Collagen constructs |
US5290271A (en) | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
ES2168091T3 (en) * | 1990-05-16 | 2002-06-01 | Genetics Inst | OSEA AND CARTILAGINOUS INDUCTION PROTEINS. |
US5218090A (en) | 1990-06-12 | 1993-06-08 | Warner-Lambert Company | EGF receptor truncates |
US5206028A (en) | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
US5318898A (en) * | 1991-04-02 | 1994-06-07 | Genetics Institute, Inc. | Production of recombinant bone-inducing proteins |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5229495A (en) | 1991-06-18 | 1993-07-20 | Ludwig Institute For Cancer Research | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
US5216126A (en) | 1991-06-19 | 1993-06-01 | Genentech, Inc. | Receptor polypeptides and their production and uses |
ATE142460T1 (en) | 1991-06-21 | 1996-09-15 | Genetics Inst | MEDICINAL PRODUCTS CONTAINING OSTEOGENIC PROTEINS |
US5306307A (en) | 1991-07-22 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant |
US5171579A (en) | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
WO1993009229A1 (en) * | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
WO1993016657A1 (en) | 1992-02-28 | 1993-09-02 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
AU3920693A (en) * | 1992-03-18 | 1993-10-21 | General Hospital Corporation, The | Four novel receptors of the TGF-beta receptor family |
EP0690871A4 (en) * | 1993-01-12 | 1999-10-20 | Univ Johns Hopkins Med | Growth differentiation factor-5 |
GB9308060D0 (en) * | 1993-04-19 | 1993-06-02 | Cancer Res Campaign Tech | Stem cell inhibitor |
US5637480A (en) * | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
ES2213745T3 (en) * | 1993-05-12 | 2004-09-01 | Genetics Institute, Llc | BMP-11 COMPOSITIONS. |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
KR100294026B1 (en) * | 1993-06-24 | 2001-09-17 | 야마자끼 순페이 | Electro-optical device |
AU697625B2 (en) * | 1993-07-09 | 1998-10-15 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-6 |
JPH09503904A (en) * | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | Growth differentiation factor-7 |
PT716610E (en) * | 1993-08-26 | 2006-08-31 | Genetics Inst Llc | MORPHOGENETIC PROTEINS OF BONES FOR HUMANS TO BE USED IN NEURAL REGENERATION |
US5455041A (en) * | 1993-09-13 | 1995-10-03 | Research Foundation Of State University Of New York At Buffalo | Method for inducing periodontal tissue regeneration |
US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
US6027919A (en) * | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
PT733109E (en) * | 1993-12-07 | 2006-07-31 | Genetics Inst Llc | MORPHOGENETIC PROTEINS OF 0SS0S PMO-12 AND PMO-13 AND THEIR COMPOSITIONS FOR TENDAO INDUCTION |
US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5520923A (en) * | 1994-09-19 | 1996-05-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
ES2203701T3 (en) * | 1995-06-05 | 2004-04-16 | Genetics Institute, Llc | USE OF BONE MORPHOGENIC PROTEINS TO HEAL AND REPAIR CONJUNCTIVE FABRIC UNIONS. |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
IT1302534B1 (en) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR |
US6420243B1 (en) * | 2000-12-04 | 2002-07-16 | Motorola, Inc. | Method for producing SOI wafers by delamination |
-
1994
- 1994-12-06 PT PT95904255T patent/PT733109E/en unknown
- 1994-12-06 ES ES95904255T patent/ES2255059T3/en not_active Expired - Lifetime
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991018047A2 (en) * | 1990-05-24 | 1991-11-28 | Genentech, Inc. | Mammalian expression of the bmp-2 family |
WO1993000432A1 (en) * | 1991-06-25 | 1993-01-07 | Genetics Institute, Inc. | Bmp-9 compositions |
WO1993016099A2 (en) * | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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USRE41286E1 (en) | 1997-08-14 | 2010-04-27 | Zimmer Orthobiologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
US8546334B2 (en) | 2001-11-19 | 2013-10-01 | Scil Technology Gmbh | Device having osteoinductive and osteoconductive properties |
US7763270B2 (en) | 2002-09-10 | 2010-07-27 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
US8257728B2 (en) | 2002-09-10 | 2012-09-04 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
US9545377B2 (en) | 2004-10-14 | 2017-01-17 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US8870954B2 (en) | 2008-09-09 | 2014-10-28 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
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