WO1994002184A1 - Tissue augmentation - Google Patents
Tissue augmentation Download PDFInfo
- Publication number
- WO1994002184A1 WO1994002184A1 PCT/SE1993/000586 SE9300586W WO9402184A1 WO 1994002184 A1 WO1994002184 A1 WO 1994002184A1 SE 9300586 W SE9300586 W SE 9300586W WO 9402184 A1 WO9402184 A1 WO 9402184A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- tissue
- polymer
- poly
- injection
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Definitions
- the present invention relates to tissue augmentation. More precisely the invention relates to use of a biologically degradable polymer for injection into a tissue for the purpose of joining and/or augmenting the same.
- WO 91/01126 a floating membrane of biologically degradable material is described which hardens in situ following injection into dental tooth pockets.
- This material is used for tissue regeneration and cannot be used for tissue augmentation as it comprises pores in the range 3-500 ⁇ m, enabling cells etc. to pass through the membrane and thereby growing together with surrounding tissues.
- the present invention provides tissue augmentation by a new use of known polymer materials.
- the polymer materials being used according to the invention are biocompatible and are well known within the medical field. These materials can be made in ectable and their nature is such that they remain at the site where they have been applied by injection. In this context the difference between filling out tissue and augmenting tissue must be emphasized.
- the polymer is injected into the tissue and when it has hardened it becomes a network controlled by the injection. This network joins the tissue desired to be augmented. With other words, this creates an active augmentation with a number of augmenting points in the tissue. During the healing process, this netword also exerts a certain degree of irritation, with the augmenting material disappearing and being replaced with connective tissue.
- the polymer being used in the composition of the invention can be polyglycolides and copolymerisates thereof, polylactides and copolymerisates thereof, poly- ⁇ -hydroxybutyrate andcopolymerisa ⁇ tes thereof, poly-p-dioxanon, poly- ⁇ -valerolactone, poly- €- caprolactone, methylmethacrylate-N-vinyl pyrrolidone copolymeri- sate, polyesther amides, polyesthers of oxanoic acid, polydihy- dropyranes, poly-alcyl-2-cyanoacrylates, polyurethanes, polyviny- lalcohol, polypeptides, poly- ⁇ -malic acid, poly- ⁇ -alcanoic acids and alginates of different forms. It is also possible to use a combination of one or more of these polymers. The amount of the polymer depends on the molecular weight of the polymer. For a high molecular weight polymer
- the above polymers for use in the present composition are in a liquid form at the time of applying by injection and in solid or semi solid form following injection into the tissue desired to be augmentented.
- the polymer is dissolved in a solvent, such as acetone, prior to the injection into the tissue.
- a solvent such as acetone
- alginates in liquid forms these are crosslinked in the tissue by 2-valent ions.
- the composition is also provided with a drug, such as, for example, growth promoting agents and antibiotics.
- a drug such as, for example, growth promoting agents and antibiotics.
- the composition can optionally be provided with monofilament, e.g. small pieces of vicrylsuture to increase the reinforcing effect of the polymer network.
- Yet another embodiment of the invention is to comprise already known filling or expanding material, such as collagen, glucose amino glucans etc. , in the composition according to the in ⁇ vention.
- Especially preferred filling materials are those forming a gas in aqueous environment at about 37°C, such as particulate citric acid and sodium bicarbonate. The amount thereof determines the degree of sweeling of the composition in vivo following injection thereof and gives "spongy" or porous properties to the composition.
- Another preferred expanding material is dextranomer particles giving the injected composition porous properties. The amount of dextranomer particles is choosen to enable modulation of the composition following injection.
- a cannula or other suitable instrument is inserted into the tissue where the augmentation is desired.
- a cannula or catheter filled with liquid a composition comprising a polymer material is inserted in the cavity (-ies), and thereafter the composition is injected therein.
- the cannula is withdrawn and the composition is allowed to harden.
- a crack in a menisc can be joined according to the invention in the following way: A sharp, cutting needle is, under atropic guidance, inserted in the crack so that this is penetrated, and thereafter the needle is withdrawn. A mass comprising 30% polylactide in acetone reinforced with 2 mm pieces of monofilament vicrylsuture is inserted in the crack by a catheter provided with a cannula. The mass is injected so that a lump is formed in the beginning and end of the crack and the cannula is slowly withdrawn. During the first 5 to 10 minutes after the application the crack is pressed together with a blunt instrument, e.g. the sleeve of the needle catheter.
- a blunt instrument e.g. the sleeve of the needle catheter.
- a common defective of children of up to 10 years of age is in ⁇ complete function of the inlet of the urether into the urine bladder.
- the normal back valve function has been lost and urine is flowing back from the bladder to the urether. Therefore, these children often have urether infections with accompanied threate ⁇ ned kidney function. To protect the kidneys, these children often need antibiotics for years. If this does not help, surgery is performed. It is a costly and relatively complicated operation with long term healing and great discomfort for the patient.
- a tissue augmentation was performed with cystoscopic technique by inserting a needle in the wall of the bladder beneath the mucous membrane.
- the body is provided with shut off mechanisms of sphincter type in above all the gastro-intestinal tract and in the urethra of the urine bladder.
- shut off mechanisms of sphincter type in above all the gastro-intestinal tract and in the urethra of the urine bladder.
- the pylorus has a "ring muscle” which rapidly and effectively can shut off the contents of the stomach.
- the lower part of the stomach is closed with a ring muscle so that food can be portioned in the intestine in a controlled way.
- the last part of the intestine has a double sphincter to securely hold faeces under control.
- the ring closing function can partly be lost or impaired forming a leakage. This is very embarassing and a great problem for many patients.
- the conditions are not life threate ⁇ ning and often associated with high age and therefore the hospitals give no priority to this cause. A simplified method would undoubtedly be very welcome for patients as well as physicians.
- Example 5 Tissue augmentation combined with filling A solution of 20 g of high molecule weight polylactide in 100 g of acetone was prepared. To the resulting highly viscous solution was added about 20 g dry dextranomer particles which allow the solution to be modulated following injection. The mixture was allowed to stabilize. After transfer to a syringe the slurry was injected into the wall of a pig bladder. Histological examination three months later revealed a localized white patch with multiple channels and fibrous tissue ligaments. There were no signs of a foreign body reaction.
- Example 6 Tissue augmentation combined with filling Particles of 1-polylactide were formed by heating a mixture of said material with a surplus of sodium bicarbonate crystals according to the procedure described in WO 92/21326 until the polylactide had melted and evenly mixed with the salt crystals. The mixture was cooled and transferred to distilled water. 5 grams of the thus obtained acetone-insoluble lactide particles were dried and mixed with a solution made from 5 grams of dl- polylactide in 100 grams of acetone. This gives a coherent slurry.
- Example 7 Tissue augmentation combined with filling
- a solution of 20 grams of dl-polylactide/polyglycolide copolymer dissolved in 100 grams of acetone was added 5 grams of a microcrystalline powder mixture of equimolar amounts of citric acid and sodium bicarbonate.
- the resulting slurry was transferred to syringes and injected in 0.5 ml portions into the earlaps of young pigs.
- the next day a 2-3 ml foam had developed that felt like semi hard tissue like the cartilage itself.
- chlorhexidine 500 mg was melted into 5 grams of 1-lactide and casted to particles as described in WO 92/21326. After mixing with a solution made of 5 grams of dl-polylactide in 50 grams of acetone, the resulting fluid was tested for release of chlorhexi ⁇ dine in a water system. The composition released chlorhexidine for more than 30 days.
Abstract
The present invention relates to use of a biologically degradable polymer for manufacturing of a composition for treating an impaired tissue by injecting said composition into said tissue for the purpose of joining and/or augmenting the same, said composition being in liquid state at the time of injection and in solid state following injection.
Description
Tissue Augmentation.
The present invention relates to tissue augmentation. More precisely the invention relates to use of a biologically degradable polymer for injection into a tissue for the purpose of joining and/or augmenting the same.
Most commonly, formed cracks or impaired tissue are not treated at all but there exists some surgical methods for treating said defectives. However, these surgical methods are time consuming and not always effective. Therefore, there is a large need for rapid and effective treatment in view of the great number of patients suffering from the above conditions. A common example is tissue impairement due to decreased function of the sphincter muscle of the intestine or urether.
It is previously known to treat impaired tissue with material being expected to remain in the patients body for the rest of the patients life following incorporation thereof. Examples of such material are polymethacrylate, Teflon paste and apatite. However, the effect obtained with these materials is only filling and not tissue joining or augmenting. The same applies for the biologi¬ cally degradable material collagen and glucose amino glucans previously also being used for treating impaired tissue.
In WO 91/01126 a floating membrane of biologically degradable material is described which hardens in situ following injection into dental tooth pockets. This material is used for tissue regeneration and cannot be used for tissue augmentation as it comprises pores in the range 3-500 μm, enabling cells etc. to pass through the membrane and thereby growing together with surrounding tissues.
The present invention provides tissue augmentation by a new use of known polymer materials. The polymer materials being used according to the invention are biocompatible and are well known within the medical field. These materials can be made in ectable and their nature is such that they remain at the site where they have been applied by injection. In this context the difference
between filling out tissue and augmenting tissue must be emphasized. According to the invention the polymer is injected into the tissue and when it has hardened it becomes a network controlled by the injection. This network joins the tissue desired to be augmented. With other words, this creates an active augmentation with a number of augmenting points in the tissue. During the healing process, this netword also exerts a certain degree of irritation, with the augmenting material disappearing and being replaced with connective tissue.
The polymer being used in the composition of the invention can be polyglycolides and copolymerisates thereof, polylactides and copolymerisates thereof, poly-β-hydroxybutyrate andcopolymerisa¬ tes thereof, poly-p-dioxanon, poly-δ-valerolactone, poly-€- caprolactone, methylmethacrylate-N-vinyl pyrrolidone copolymeri- sate, polyesther amides, polyesthers of oxanoic acid, polydihy- dropyranes, poly-alcyl-2-cyanoacrylates, polyurethanes, polyviny- lalcohol, polypeptides, poly-β-malic acid, poly-β-alcanoic acids and alginates of different forms. It is also possible to use a combination of one or more of these polymers. The amount of the polymer depends on the molecular weight of the polymer. For a high molecular weight polymer, a low concentration is satisfac¬ tory, and vice versa.
The above polymers for use in the present composition, are in a liquid form at the time of applying by injection and in solid or semi solid form following injection into the tissue desired to be augmentented. Preferably, the polymer is dissolved in a solvent, such as acetone, prior to the injection into the tissue. Prior to injection, it is also possible to heat the polymer to < 42°C, which is the maximal temperature tolerated by the tissue. When alginates in liquid forms are used these are crosslinked in the tissue by 2-valent ions.
According to another embodiment of the invention, the composition is also provided with a drug, such as, for example, growth promoting agents and antibiotics.
Furthermore, the composition can optionally be provided with monofilament, e.g. small pieces of vicrylsuture to increase the reinforcing effect of the polymer network.
Yet another embodiment of the invention is to comprise already known filling or expanding material, such as collagen, glucose amino glucans etc. , in the composition according to the in¬ vention. Especially preferred filling materials are those forming a gas in aqueous environment at about 37°C, such as particulate citric acid and sodium bicarbonate. The amount thereof determines the degree of sweeling of the composition in vivo following injection thereof and gives "spongy" or porous properties to the composition. Another preferred expanding material is dextranomer particles giving the injected composition porous properties. The amount of dextranomer particles is choosen to enable modulation of the composition following injection.
The method of tissue augmentation according to the invention can be described according to the following:
1. A cannula or other suitable instrument is inserted into the tissue where the augmentation is desired.
2. By the instrument, which can be cutting or blunt, cavities are created in the tissue.
3. The instrument is withdrawn.
4. A cannula or catheter filled with liquid a composition comprising a polymer material is inserted in the cavity (-ies), and thereafter the composition is injected therein.
5. The cannula is withdrawn and the composition is allowed to harden.
The invention will now be described more closely below in relation to some examples.
Example 1:
Joining of a menisc
A crack in a menisc can be joined according to the invention in the following way:
A sharp, cutting needle is, under atropic guidance, inserted in the crack so that this is penetrated, and thereafter the needle is withdrawn. A mass comprising 30% polylactide in acetone reinforced with 2 mm pieces of monofilament vicrylsuture is inserted in the crack by a catheter provided with a cannula. The mass is injected so that a lump is formed in the beginning and end of the crack and the cannula is slowly withdrawn. During the first 5 to 10 minutes after the application the crack is pressed together with a blunt instrument, e.g. the sleeve of the needle catheter.
Example 2: Reflux correcting
A common defective of children of up to 10 years of age is in¬ complete function of the inlet of the urether into the urine bladder. The normal back valve function has been lost and urine is flowing back from the bladder to the urether. Therefore, these children often have urether infections with accompanied threate¬ ned kidney function. To protect the kidneys, these children often need antibiotics for years. If this does not help, surgery is performed. It is a costly and relatively complicated operation with long term healing and great discomfort for the patient.
On the basis that the defective has its origin in a tissue impairement of the bladder wall, a tissue augmentation was performed with cystoscopic technique by inserting a needle in the wall of the bladder beneath the mucous membrane.
This tissue augmentation was performed by injecting about 1 ml 20% polymer lactide solution under the mucous membrane of the bladder. Following hardening of the solution, the formed disc exerted good resistance against the inner pressure of the bladder preventing back leakage. The lactide polymer is now degraded (6 months after injection) and leaves a connective tissue providing sufficient resistance for a remained back valve function.
Example 3:
Augmentation of sphincter function
The body is provided with shut off mechanisms of sphincter type in above all the gastro-intestinal tract and in the urethra of the urine bladder. As the abdomen is exposed to overpressure in connection with body exercise or sneezing/coughing, these openings have to be shut effectively. Therefore, the pylorus has a "ring muscle" which rapidly and effectively can shut off the contents of the stomach. Also the lower part of the stomach is closed with a ring muscle so that food can be portioned in the intestine in a controlled way. Finally, the last part of the intestine has a double sphincter to securely hold faeces under control. In all of these cases, and in more not disclosed cases, the ring closing function can partly be lost or impaired forming a leakage. This is very embarassing and a great problem for many patients. On the other hand, the conditions are not life threate¬ ning and often associated with high age and therefore the hospitals give no priority to this cause. A simplified method would undoubtedly be very welcome for patients as well as physicians.
In a majority of sphincter function disturbances there is no absolute hindrance to reestablish full function. In these cases a tissue augmentation would be sufficient to give the support needed by the remaining function to function properly.
A 55 year old woman called for urine leakage in connection with physical exercise. The problem was increasing over the years. Following investigation with fiberoptic technique and ultrasonic waves it was established that the sphincter had been partially impaired. After injection of 5 ml 20% polymer lactide solution under the mucous membrane reforming a circular opening, the woman had no complications 3 months following the treatment.
Corresponding treatments of other ring muscle sphincters are appearent for the skilled man within this art.
Example 4:
Vocal cord atrophy
A special case was a patient whose voice had been nearly lost after a radiation treatment of the neck region. Following investigation, it was established that one of the vocal cords had atrophiated and been longitudinally displaced. This led to an almost wheezing voice being awkward for the patient in his working life. Under fiberoptic controll an injection in the impaired part of the vocal cord was given with 2 ml 20% of lactide polymer solution. A voice function sufficient for the patient was stabilized after 3 months.
Example 5 : Tissue augmentation combined with filling A solution of 20 g of high molecule weight polylactide in 100 g of acetone was prepared. To the resulting highly viscous solution was added about 20 g dry dextranomer particles which allow the solution to be modulated following injection. The mixture was allowed to stabilize. After transfer to a syringe the slurry was injected into the wall of a pig bladder. Histological examination three months later revealed a localized white patch with multiple channels and fibrous tissue ligaments. There were no signs of a foreign body reaction.
Example 6 : Tissue augmentation combined with filling Particles of 1-polylactide were formed by heating a mixture of said material with a surplus of sodium bicarbonate crystals according to the procedure described in WO 92/21326 until the polylactide had melted and evenly mixed with the salt crystals. The mixture was cooled and transferred to distilled water. 5 grams of the thus obtained acetone-insoluble lactide particles were dried and mixed with a solution made from 5 grams of dl- polylactide in 100 grams of acetone. This gives a coherent slurry.
0,2 ml of that mixture was injected subcutaneously into a nude mouse. The bolus so formed was very pronounced and stayed the same throughout a 12 weeks period. This formulation shows excellent properties for soft tissue augmentation. Initially
there was an inflammatory reaction that lasted for 6 hours. At the end of the experiment, histological examination did not reveal any foreign body reaction.
Example 7 : Tissue augmentation combined with filling To a solution of 20 grams of dl-polylactide/polyglycolide copolymer dissolved in 100 grams of acetone was added 5 grams of a microcrystalline powder mixture of equimolar amounts of citric acid and sodium bicarbonate. The resulting slurry was transferred to syringes and injected in 0.5 ml portions into the earlaps of young pigs. The next day a 2-3 ml foam had developed that felt like semi hard tissue like the cartilage itself. These properties were obtained because of the gas evolving nature of the filling material. In principle, any filling material evolving gas in an aqueous system at about 37°C can be used. Three months later the animal was sacrificed and at autopsy the foam was still very "spongy" and there were no signs of foreign body reaction.
Release test
500 mg of chlorhexidine was melted into 5 grams of 1-lactide and casted to particles as described in WO 92/21326. After mixing with a solution made of 5 grams of dl-polylactide in 50 grams of acetone, the resulting fluid was tested for release of chlorhexi¬ dine in a water system. The composition released chlorhexidine for more than 30 days.
From the above it appears that the disclosed tissue augmentation obtained by injection under fiberoptic guidance is a fast, cheap and simple method probably not leading to a permanent condition but which under some years recreate a lost function. Because of the simplicity of the method the treatment can easily be repeated as needed.
Claims
1. Use of a biologically degradable polymer for manufacturing of a composition for treating an impaired tissue by injecting said composition into said tissue for the purpose of joining and/or augmenting thesame, said composition being in liquid state at the time of injection and in solid state following injection.
2. Use according to claim 1, wherein the biologically degrad¬ able polymer being chosen from the group consisting of polyglycolides and copolymers thereof, polylactides and copolyme- res thereof, poly-β-hydroxybutyrate and copolymeres thereof, poly-p-dioxanone, poly-δ-valerolactone, poly-e-caprolactone, methylmetacrylate-N-vinyl pyrrolidone copolymeres, polyesteramid- es, polyesters of oxalic acid, polydihydropyranes, poly-alkyl-2- cyanoacrylates, polyurethanes, polyvinylalcohol, polypeptider, poly-β-maleic acid, poly-β-alkanoinic acids, alginates in different forms, and a combination of one or more of these.
3. Use according to claims 1 or 2, wherein said polymer is dissolved in a solvent before said injection.
4. Use according to claims 1 or 2, wherein said polymer is heated before said injection.
5. Use according to claims 1 or 2, wherein said polymer is cross linked in situ in said tissue.
6. Use according to one or more of the claims 1-5, wherein said composition also comprises a drug.
7. Use according to one or more of the claims 1-6, wherein said composition also comprises monofilaments.
8. Use according to one or more of the claims 1-7, wherein said composition also comprises tissue expanding agents.
9. Composition for tissue augmentation comprising 1-50% by weight of a biologically degradable polymer and at least 1% by weight of dextranomer particles.
10. Composition for tissue augmentation comprising 1-50% by weight of a biologically degradable polymer and at least 1% by weight of gas forming agent(s).
11. Composition according to claim 11, wherein the gas forming agents are particulate citric acid and sodium bicarbonate.
12. Composition for tissue augmentation comprising 1-50% by weight of a biologically degradable polymer and at least 1% by weight of solvent-insoluble polymer particles.
13. A method of tissue augmentation, comprising a) insertion of an instrument into a tissue where the augmenta¬ tion is desired; b) creation of cavity(ies) in the tissue by said instrument; c) removal of the instrument; d) insertion of a cannula or catheter filled with a liquid composition comprising a hardenable biologically degradable polymer in the cavity (-ies), and injection of the composition therein; and e) withdrawal of the cannula and hardening of the polymer.
14. A method according to claim 13, wherein it is performed under fiberoptic guidance.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9202208A SE509991C2 (en) | 1992-07-20 | 1992-07-20 | Biodegradable tissue enhancement |
SE9202208-6 | 1992-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994002184A1 true WO1994002184A1 (en) | 1994-02-03 |
Family
ID=20386819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1993/000586 WO1994002184A1 (en) | 1992-07-20 | 1993-06-28 | Tissue augmentation |
Country Status (2)
Country | Link |
---|---|
SE (1) | SE509991C2 (en) |
WO (1) | WO1994002184A1 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994021299A1 (en) * | 1993-03-19 | 1994-09-29 | Medinvent | A composition and a method for tissue augmentation |
EP0635272A1 (en) * | 1993-07-20 | 1995-01-25 | Ethicon Inc. | Liquid absorbable copolymers for parenteral applications |
EP0711548A1 (en) * | 1994-10-18 | 1996-05-15 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
EP0711794A1 (en) * | 1994-10-18 | 1996-05-15 | Ethicon, Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
WO1996025891A1 (en) * | 1992-09-01 | 1996-08-29 | Ortho-Motion, Inc. | Articulating external fixation device |
WO2001019422A1 (en) * | 1999-09-14 | 2001-03-22 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US6335383B1 (en) | 1994-10-18 | 2002-01-01 | Ethicon, Inc. | Microdispersions for coating surgical devices |
US6423332B1 (en) | 2000-05-26 | 2002-07-23 | Ethicon, Inc. | Method and composition for deforming soft tissues |
US6555123B2 (en) | 1999-09-14 | 2003-04-29 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US7731758B2 (en) | 1997-06-13 | 2010-06-08 | Aventis Pharmaceuticals Holdings, Inc. | Implant for subcutaneous or intradermal injection |
US9125719B2 (en) | 2003-05-08 | 2015-09-08 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
US9144631B2 (en) | 2003-01-27 | 2015-09-29 | Benedicte Asius | Ceramic-based injectable implants which are used to fill wrinkles, cutaneous depressions and scars, and preparation method thereof |
US9555155B2 (en) | 2014-12-11 | 2017-01-31 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
US10500303B2 (en) | 2014-08-15 | 2019-12-10 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595713A (en) * | 1985-01-22 | 1986-06-17 | Hexcel Corporation | Medical putty for tissue augmentation |
US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
WO1991001126A1 (en) * | 1989-07-24 | 1991-02-07 | Vipont Pharmaceutical Inc. | Biodegradable system for regenerating the periodontium |
US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
-
1992
- 1992-07-20 SE SE9202208A patent/SE509991C2/en not_active IP Right Cessation
-
1993
- 1993-06-28 WO PCT/SE1993/000586 patent/WO1994002184A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595713A (en) * | 1985-01-22 | 1986-06-17 | Hexcel Corporation | Medical putty for tissue augmentation |
US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
WO1991001126A1 (en) * | 1989-07-24 | 1991-02-07 | Vipont Pharmaceutical Inc. | Biodegradable system for regenerating the periodontium |
US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996025891A1 (en) * | 1992-09-01 | 1996-08-29 | Ortho-Motion, Inc. | Articulating external fixation device |
US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
WO1994021299A1 (en) * | 1993-03-19 | 1994-09-29 | Medinvent | A composition and a method for tissue augmentation |
EP0635272A1 (en) * | 1993-07-20 | 1995-01-25 | Ethicon Inc. | Liquid absorbable copolymers for parenteral applications |
EP0711794A1 (en) * | 1994-10-18 | 1996-05-15 | Ethicon, Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
US5599852A (en) * | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
EP0711548A1 (en) * | 1994-10-18 | 1996-05-15 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
AU696591B2 (en) * | 1994-10-18 | 1998-09-17 | Ethicon Inc. | Injectable microdispersions for soft tissue repair and augmentation |
US5824333A (en) * | 1994-10-18 | 1998-10-20 | Ethicon, Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
AU706434B2 (en) * | 1994-10-18 | 1999-06-17 | Ethicon Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
US6335383B1 (en) | 1994-10-18 | 2002-01-01 | Ethicon, Inc. | Microdispersions for coating surgical devices |
US8414657B2 (en) | 1997-06-13 | 2013-04-09 | Valeant International Bermuda | Method for subcutaneous or intradermal injection |
US7731758B2 (en) | 1997-06-13 | 2010-06-08 | Aventis Pharmaceuticals Holdings, Inc. | Implant for subcutaneous or intradermal injection |
US7025980B1 (en) | 1999-09-14 | 2006-04-11 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US6585994B2 (en) | 1999-09-14 | 2003-07-01 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
JP2003509128A (en) * | 1999-09-14 | 2003-03-11 | テファ, インコーポレイテッド | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation and viscosupplementation |
WO2001019422A1 (en) * | 1999-09-14 | 2001-03-22 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US6555123B2 (en) | 1999-09-14 | 2003-04-29 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US6423332B1 (en) | 2000-05-26 | 2002-07-23 | Ethicon, Inc. | Method and composition for deforming soft tissues |
US9144631B2 (en) | 2003-01-27 | 2015-09-29 | Benedicte Asius | Ceramic-based injectable implants which are used to fill wrinkles, cutaneous depressions and scars, and preparation method thereof |
US10314683B2 (en) | 2003-05-08 | 2019-06-11 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
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US10111738B2 (en) | 2003-05-08 | 2018-10-30 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
US10136982B2 (en) | 2003-05-08 | 2018-11-27 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
US9125719B2 (en) | 2003-05-08 | 2015-09-08 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
US10500303B2 (en) | 2014-08-15 | 2019-12-10 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US11426484B2 (en) | 2014-08-15 | 2022-08-30 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US11944709B2 (en) | 2014-08-15 | 2024-04-02 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US9555155B2 (en) | 2014-12-11 | 2017-01-31 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
US10227713B2 (en) | 2014-12-11 | 2019-03-12 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
US10590566B2 (en) | 2014-12-11 | 2020-03-17 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
US11828006B2 (en) | 2014-12-11 | 2023-11-28 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
Also Published As
Publication number | Publication date |
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SE9202208L (en) | 1994-01-21 |
SE509991C2 (en) | 1999-03-29 |
SE9202208D0 (en) | 1992-07-20 |
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