WO1993021874A3 - Subconjunctival implants for ocular drug delivery - Google Patents

Subconjunctival implants for ocular drug delivery Download PDF

Info

Publication number
WO1993021874A3
WO1993021874A3 PCT/US1993/003776 US9303776W WO9321874A3 WO 1993021874 A3 WO1993021874 A3 WO 1993021874A3 US 9303776 W US9303776 W US 9303776W WO 9321874 A3 WO9321874 A3 WO 9321874A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye
conjunctiva
active agent
drug delivery
under
Prior art date
Application number
PCT/US1993/003776
Other languages
French (fr)
Other versions
WO1993021874A2 (en
Inventor
Arlene E Gwon
David Meadows
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of WO1993021874A2 publication Critical patent/WO1993021874A2/en
Publication of WO1993021874A3 publication Critical patent/WO1993021874A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Abstract

A system for providing controlled release of an active agent in an eye includes a device (10) with a shape thereof for enabling placement of the device under a conjunctiva of an eye and additionally preventing migration of the device (10) in the eye after placement of the device under the conjunctiva. The device may be formed of a material permeable to the passage of an agent (16) disposed in said device. In addition, a tracer may be incorporated in the device (10) to enable visual indication of the amount of active agent (16) in said device (10) when said device (10) is disposed under the conjunctiva. To selectively treat specific areas of the eye, an impermeable layer (26) may be provided for preventing diffusion of the active agent (16) from a selected area (28) of the device (10).
PCT/US1993/003776 1992-05-04 1993-04-22 Subconjunctival implants for ocular drug delivery WO1993021874A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/878,034 1992-05-04
US07/878,034 US5178635A (en) 1992-05-04 1992-05-04 Method for determining amount of medication in an implantable device

Publications (2)

Publication Number Publication Date
WO1993021874A2 WO1993021874A2 (en) 1993-11-11
WO1993021874A3 true WO1993021874A3 (en) 1994-01-06

Family

ID=25371235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/003776 WO1993021874A2 (en) 1992-05-04 1993-04-22 Subconjunctival implants for ocular drug delivery

Country Status (3)

Country Link
US (3) US5178635A (en)
AU (1) AU4111093A (en)
WO (1) WO1993021874A2 (en)

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US5476511A (en) 1995-12-19
US5178635A (en) 1993-01-12

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