WO1993003671A1 - Method of mri imaging using diamagnetic contrast agents - Google Patents
Method of mri imaging using diamagnetic contrast agents Download PDFInfo
- Publication number
- WO1993003671A1 WO1993003671A1 PCT/US1991/005757 US9105757W WO9303671A1 WO 1993003671 A1 WO1993003671 A1 WO 1993003671A1 US 9105757 W US9105757 W US 9105757W WO 9303671 A1 WO9303671 A1 WO 9303671A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- imaging
- microspheres
- mri
- carried out
- technique
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Nanotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Signal Processing (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1991/005757 WO1993003671A1 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents |
EP19920902640 EP0599839A4 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents. |
CA002115582A CA2115582A1 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1991/005757 WO1993003671A1 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents |
CA002115582A CA2115582A1 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993003671A1 true WO1993003671A1 (en) | 1993-03-04 |
Family
ID=25677018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/005757 WO1993003671A1 (en) | 1991-08-13 | 1991-08-13 | Method of mri imaging using diamagnetic contrast agents |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1993003671A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US5605673A (en) * | 1993-07-30 | 1997-02-25 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
DE19626530A1 (en) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | Aqueous magnetic resonance contrast agent compositions |
US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
-
1991
- 1991-08-13 WO PCT/US1991/005757 patent/WO1993003671A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
Non-Patent Citations (2)
Title |
---|
"Von Nostrand's Scientific Encyclopedia", published 1967, by D. Von Nostrand's Company, Inc., (Princeton, New Jersey), see page 1063. * |
See also references of EP0599839A4 * |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6372195B1 (en) | 1993-07-30 | 2002-04-16 | Alliance Pharmaceutical Corp. | Mixed gas microbubble compositions |
US5695741A (en) * | 1993-07-30 | 1997-12-09 | Alliance Pharmaceutical Corp. | Stable microbubble precursors |
US7141235B2 (en) | 1993-07-30 | 2006-11-28 | Imcor Pharmaceutical Co. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US5639443A (en) * | 1993-07-30 | 1997-06-17 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions |
US7005120B2 (en) | 1993-07-30 | 2006-02-28 | Imcor Pharmaceutical Company | Osmotically stabilized microbubble preparations |
US6953569B2 (en) | 1993-07-30 | 2005-10-11 | Imcor Pharmaceutical Company | Mixed gas microbubble compositions |
US5720938A (en) * | 1993-07-30 | 1998-02-24 | Alliance Pharmaceutical Corp. | Systems for the formation of microbubbles |
US6258339B1 (en) | 1993-07-30 | 2001-07-10 | Alliance Pharmaceutical Corp. | Osmotically stabilized microbubble preparations |
US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US6939531B2 (en) | 1993-07-30 | 2005-09-06 | Imcor Pharmaceutical Company | Ultrasonic imaging system utilizing a long-persistence contrast agent |
US6706253B2 (en) | 1993-07-30 | 2004-03-16 | Ernest G. Schutt | Osmotically stabilized microbubble preparations |
US6287539B1 (en) | 1993-07-30 | 2001-09-11 | Alliance Pharmaceuticals Corp. | Methods of imaging using osmotically stabilized microbubble preparations |
US5626833A (en) * | 1993-07-30 | 1997-05-06 | Alliance Pharmaceutical Corp. | Ultrasound imaging method using microbubbles |
US5605673A (en) * | 1993-07-30 | 1997-02-25 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
US6280705B1 (en) | 1993-07-30 | 2001-08-28 | Alliance Pharmaceutical Corp. | Kits & systems for ultrasonic imaging |
US6280704B1 (en) | 1993-07-30 | 2001-08-28 | Alliance Pharmaceutical Corp. | Ultrasonic imaging system utilizing a long-persistence contrast agent |
US5733527A (en) * | 1994-09-28 | 1998-03-31 | Alliance Pharmaceutical Corp. | Methods for harmonic imaging with ultrasound |
US6036644A (en) * | 1994-09-28 | 2000-03-14 | Alliance Pharmaceutical Corp. | Enhanced methods of ultrasound imaging using multiple frequencies |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US6019960A (en) * | 1994-09-28 | 2000-02-01 | Alliance Pharmaceutical Corp. | Systems for harmonic ultrasound imaging |
US6056943A (en) * | 1994-09-28 | 2000-05-02 | Alliance Pharmaceutical Corp. | Methods of ultrasound imaging using phospholipid stabilized microbubbles |
US7374744B2 (en) | 1994-09-28 | 2008-05-20 | Imcor Pharmaceutical Co. | Harmonic ultrasound imaging with microbubbles |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US6193952B1 (en) | 1995-06-07 | 2001-02-27 | Alliance Pharmaceutical Corp. | Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement |
DE19626530A1 (en) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | Aqueous magnetic resonance contrast agent compositions |
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