USRE39157E1 - Apparatus for restenosis treatment - Google Patents
Apparatus for restenosis treatment Download PDFInfo
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- USRE39157E1 USRE39157E1 US08/850,073 US85007397A USRE39157E US RE39157 E1 USRE39157 E1 US RE39157E1 US 85007397 A US85007397 A US 85007397A US RE39157 E USRE39157 E US RE39157E
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- 208000037803 restenosis Diseases 0.000 title claims description 21
- 230000002285 radioactive effect Effects 0.000 claims abstract description 67
- 210000001367 artery Anatomy 0.000 claims abstract description 65
- 238000002399 angioplasty Methods 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 39
- 230000005855 radiation Effects 0.000 claims description 35
- 230000003902 lesion Effects 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- 230000010412 perfusion Effects 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000010339 dilation Effects 0.000 description 7
- 208000031481 Pathologic Constriction Diseases 0.000 description 6
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 6
- 208000037804 stenosis Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000036262 stenosis Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000012857 radioactive material Substances 0.000 description 2
- CIOAGBVUUVVLOB-NJFSPNSNSA-N Strontium-90 Chemical compound [90Sr] CIOAGBVUUVVLOB-NJFSPNSNSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- -1 but not limited to Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007887 coronary angioplasty Methods 0.000 description 1
- PCHJSUWPFVWCPO-OUBTZVSYSA-N gold-198 Chemical compound [198Au] PCHJSUWPFVWCPO-OUBTZVSYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical compound [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 1
- 229940044173 iodine-125 Drugs 0.000 description 1
- 238000013147 laser angioplasty Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 description 1
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22068—Centering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1047—Balloon catheters with special features or adapted for special applications having centering means, e.g. balloons having an appropriate shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
- A61N2005/1004—Intraluminal radiation therapy having expandable radiation sources
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Method and apparatus for treatment and post-treatment of the stenosed region of an artery after reduction of the region by angioplasty or other means by applying a radioactive dose to said reduced region of the artery by positioning a radioactive dose to the reduced region is disclosed.
Description
This application is a continuation of application Ser. No. 07/755,480, filed Sep. 5, 1991, now U.S. Pat. No. 5,302,168.
This invention relates generally to angiop1asty and more particularly to a method and apparatus for preventing restenosis after angioplasty or other stenosis treatment.
In the past, catheters have been developed which may be effectively inserted into blood vessels and maneuvered through a vascular tree. A balloon may be used with such catheters to expand in the vessel and open blockages found therein. In a typical percutaneous transluminal coronary angioplasty (PTCA) or percutaneous transluminal angioplasty (PTA) procedure, a guiding catheter is percutaneously introduced into the vascular system of a patient through an artery and advanced therein until the distal tip of the guiding catheter is appropriately positioned. A dilation catheter having a balloon on the distal end thereof and a guide wire are slidably disposed and introduced through the guiding catheter. The guide wire is first advanced through the distal tip of the guiding catheter until the distal end of the guide wire crosses the lesion to be dilated. The dilation catheter is then advanced over the previously introduced guide wire until the dilation balloon on the distal extremity of the dilation catheter is properly positioned inside the lesion. The balloon portion of the dilation catheter is then inflated to a predetermined size to radially compress the atherosclerotic plaque of the lesion against the inside of the artery wall to thereby reduce the annular stenosed area. After a period of time, the balloon is deflated so that blood flow is resumed, allowing the dilation catheter to be removed.
A major problem encountered in a significant number of patients treated by this procedure is the subsequent narrowing of the artery after the expansion treatment. Various methods and apparatus have been developed to address the restenosis problem including multiple inflations of the balloon during the original procedure, atherectomy, hot balloons, and lasers. Even the installation of permanent stents has been thought to potentially have some value in reducing restenosis rates. See, for example, U.S. Pat. No. 5,019,075 to Spears et al. wherein the region surrounding the balloon utilized in the angioplasty procedure is heated by means within the balloon, or within the skin of the balloon, upon inflation of the balloon in order to ideally fuse together fragmented segments of tissue. U.S. Pat. No. 4,733,655 to Palmaz discloses an expansible vascular graft which is expanded within a blood vessel by an angioplasty balloon to dilate and expand the lumen of the blood vessel. The Palmaz method and apparatus leaves the expandable vascular graft in place to ideally prevent recurrence of stenosis in the body passageway.
However, recent data seems to indicate that the prior art methods described above do not significantly reduce restenosis rates of occurrence. In restenosis, a proliferation of cells following angioplasty is believed to cause the lesion to reform. The rate of occurrence of restenosis is generally considered to be about 33 percent. It would therefore be desirable to have a method and apparatus to treat a lesion in order to reduce the restenosis rate of occurrence. The present invention is believed to provide a unique method and apparatus to reduce the restenosis rate of occurrence following an angioplasty or like-intended procedure.
The purpose of the invention is to provide method and apparatus to significantly reduce restenosis rates of occurrence following an angioplasty procedure. To accomplish this purpose, there is provided method and apparatus for exposing the dilated lesion to a radiation dose that will affect smooth muscle cell growth. There is provided a catheter which has at its distal end a radioactive source, the source being maneuverable to the site of a lesion which has been dilated or removed, the apparatus allowing the site to be exposed to the radiation dose that will affect smooth muscle cells such that the rapid growth of such cells can be prevented, thereby controlling restenosis.
In one aspect of the invention there is provided a method for treatment and post-treatment of the stenosed region of an artery comprising the steps of:
-
- reducing the annular stenosed area within an artery; and
- applying a radioactive dose to the area of reduced stenosis.
In another aspect of the invention there is provided a method for treatment and post-treatment of the stenosed region of an artery after reduction of said region by angioplasty or other means comprising the step of applying a radioactive dose to said reduced region of the artery.
In yet another aspect of the invention there is provided apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other means comprising:
-
- radioactive dose means; and
- positioning means operatively connected to said dose means to position said dose means within the stenosed region of an artery that has been reduced by angioplasty or other means.
With continued reference to the drawing, FIG. 1 illustrates the apparatus and method for preventing restenosis of an artery that has been enlarged by angioplasty or other procedure. Specifically, apparatus, shown generally at 10, is positioned within artery segment 12 having lesion site 14 which has previously been enlarged by angioplasty or other procedure such that atherosclerotic plaque 16 has been radially compressed by expansion of the balloon portion of an angioplasty device (not shown) or removed by other means. Device 10 having distal end 18 with tip 20 and wire wound housing 22 is positioned such that housing 22 is positioned within the lesion site 14. Housing 22 contains radioactive dose means 30 and is provided with window cut-out 32. Device 10 includes a wire wound retractable sheath 24 and catheter shaft 26 with guide wire and guide wire port 28. A radioactive dose means 30 is moveable by advancing or retracting catheter shaft 26 which may be referred to as a positioning means. Sheath 24 is drawn back when the radioactive dose means is positioned directly proximate the lesion site 14 such that window cut-out 32 is opened to expose the lesion site 14, which has been previously dilated, to a radiation dose that will affect the smooth muscle cells/plaque.
In FIG. 2 there is illustrated a device shown generally at 34 which is an alternate embodiment of the invention further including an angioplasty balloon 36 with dose means in the form of radioactive elements 38 attached thereto. Device 34 includes catheter shaft 40 having perfusion capabilities provided by holes 41 positioned proximately and distally to the balloon portion.
It is understood that the various embodiments of the subject invention are useful in the treatment of a lesion site within an artery. “Lesion site” includes those lesions which have been treated with balloon angioplasty, those lesions that have been treated by an atherectomy or laser angioplasty, those lesions that have been treated by rotational atherectomy or any other means of compressing or removing the material of the lesion which may cause trauma to the artery. It is this trauma which causes the proliferation of smooth muscle cells which method and apparatus of the subject invention is intended to inhibit.
With regard to all embodiments of the subject invention, “radioactive dose” means bombardment by particles emitted from radioactive materials including, but not limited to, materials such as Radon 222, Gold 198, Strontium 90, Radium 192, and Iodine 125. These materials may be incorporated into or delivered in a solid, liquid, or gaseous form, and the delivery of such forms is considered to be within the scope of the subject invention.
The foregoing description of the drawing illustrates various methods of the invention. It should be understood that the methods of the invention include the treatment and post-treatment of an annularly stenosed region of an artery. Most methods of treatment currently available cause some trauma to the artery. The artery in response to this trauma proliferates the growth of smooth muscle cells in many cases, and this results in restenosis at the site of the original stenosis—usually within a six-month period. The post-treatment consists of exposing the treated region of the stenosis to a radiation dose which is sufficient to retard or halt the proliferation of smooth muscle cells. It should also be pointed out that both the treatment and post-treatment could occur simultaneously if the device which removes or compresses the stenosis material also contains the radioactive dose means.
Having indicated above preferred embodiments of the present invention, it will occur to those skilled in the art that modification and alternatives can be practiced within the spirit of the invention. It is accordingly intended to define the scope of the invention only as indicated in the following claims.
Claims (41)
1. Apparatus for post-treatment of stenosed region of an artery that has been reduced by angioplasty or other means comprising:
radioactive dose means for emitting radiation; and
positioning means operatively connected to said dose means for advancing said dose means and positioning said dose means within the stenosed region of an artery that has been reduced by angioplasty or other means, said positioning means also being operatively connected to said dose means for withdrawing said dose means from the artery, the positioning means further including an angioplasty balloon, said radioactive dose means being connected to said balloon and moveable into contact with the stenosed region by expansion of said balloon.
2. The apparatus of claim 1 , wherein the radioactive dose means comprises a plurality of radioactive sources distributed around the balloon.
3. Apparatus for post-treatment of stenosed region of an artery that has been reduced by angioplasty or other means comprising:
radioactive dose means for emitting radiation; and
positioning means operatively connected to said dose means for advancing said dose means and positioning said dose means within the stenosed region of an artery that has been reduced by angioplasty or other means, said positioning means also being operatively connected to said dose means for withdrawing said dose means from the artery, the positioning means including a retractable sheath which may be removably positioned over said radioactive dose means and the dose means being located in a housing having a cut-out in a sidewall thereof, the dose means being exposed to the stenosed region by moving the sheath from a first position wherein the cut-out is covered by the sheath to a second position wherein the cut-out is not covered by the sheath.
4. The apparatus of claim 3 , wherein the housing is a wirewound housing.
5. Apparatus for post-treatment of stenosed region of an artery that has been reduced by angioplasty or other means comprising:
radioactive dose means for emitting radiation; and
positioning means operatively connected to said dose means for advancing said dose means and positioning said dose means within the stenosed region of an artery that has been reduced by angioplasty or other means, said positioning means also being operatively connected to said dose means for withdrawing said dose means from the artery, the positioning means including a retractable remotely activated cover which may be removably positioned over said radioactive dose means and the dose means being located in a housing having an opening therein, the dose means being exposed to the stenosed region by moving the remotely activated cover from a first position wherein the opening is covered by the remotely activated cover to a second position wherein the opening is not covered by the remotely activated cover.
6. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation;
a catheter; and
a positioner providing slidable motion of the radioactive dose within the catheter, the positioner arranged for advancing said dose within the stenosed region of an artery that has been reduced by angioplasty or other procedure, said positioner also being operatively connected to said dose for positioning the dose between a first position and a second position, wherein in the first position the dose is positioned within the artery in a non-deployed configuration and a second position wherein the dose is in a deployed configuration and exposed through a window in the catheter for treating at least a portion of the stenosed region of the artery, said positioner being operatively connected to said dose for withdrawing said dose from the artery after said radioactive dose is exposed to the stenosed region for a period of time sufficient to inhibit restenosis of the stenosed region.
7. The apparatus of claim 6 , wherein the dose is in solid form.
8. The apparatus of claim 6 , wherein the dose is in liquid form.
9. The apparatus of claim 6 , wherein the dose is in gaseous form.
10. Apparatus for post treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radiation source; and
a catheter having at least one lumen adapted to deliver said radiation source within the stenosed region of an artery that has been reduced by angioplasty or other procedure, said catheter also being adapted to at least partially reposition relative to the radiation source for treatment when positioned within the stenosed region of an artery, the catheter being adapted to at least partially reposition to withdraw said radiation source from the artery after said radiation source is exposed to the stenosed region for a period of time sufficient to inhibit restenosis of the stenosed region.
11. The apparatus of claim 10 , wherein the radiation source is in solid form.
12. The apparatus of claim 10 , wherein the radiation source is in a liquid form.
13. The apparatus of claim 10 , wherein the radiation source is in gaseous form.
14. The apparatus of claim 10 , wherein the catheter includes a balloon, the catheter defining at least one hole distal to the balloon and at least one hole proximal to the balloon.
15. The apparatus of claim 14 , wherein the catheter includes a first lumen in fluid communication with the balloon.
16. The apparatus of claim 15 , wherein the catheter defines a plurality of perfusion holes and includes a second lumen in fluid communication with perfusion holes which allow perfusion of blood in the artery during inflation of the balloon.
17. The apparatus of claim 10 , wherein the radiation source provides a radiation dose to the stenosed region through a window in the catheter.
18. The apparatus of claim 10 , wherein the catheter includes a balloon inflated by a fluid having the radiation dose means incorporated therein.
19. The apparatus of claim 6 , wherein the radioactive dose for emitting radiation is positioned within the catheter, the catheter defining a housing, wherein in the first position the dose is shielded from treating the stenosed region and in the second position the housing is deployed to at least partially expose the dose to the stenosed region of the artery.
20. The apparatus of claim 19 , wherein in the second deployed position a sheath is withdrawn relative to the dose positioned in the stenosed region to expose the stenosed region to the dose.
21. The apparatus of claim 10 , wherein the catheter includes a balloon with the radiation source for emitting radiation incorporated into and enclosed within the material of the balloon and the balloon is expanded in the second deployed configuration positioning the balloon at least partially in contact with the stenosed region of the artery.
22. The apparatus of claim 21 , wherein the portion of the device that is expanded includes a balloon with the radiation source positioned on the surface of the balloon.
23. The apparatus for post-treatment of a stenosed region of claim 17 , wherein the dose is a liquid.
24. The apparatus for post-treatment of a stenosed region of claim 17 , wherein the dose is a gas.
25. The apparatus for post-treatment of a stenosed region of claim 21 , wherein the dose incorporated into the balloon material is a solid.
26. The apparatus for post-treatment of a stenosed region of claim 21 , wherein the dose incorporated into the balloon material is a liquid.
27. The apparatus for post-treatment of a stenosed region of claim 21 , wherein the dose incorporated into the balloon material is a gas.
28. The apparatus for post-treatment of a stenosed region of claim 6 , wherein the apparatus controls the exposure of the dose by controlling the radial direction and axial position of the window.
29. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation;
a catheter movable with respect to the dose; and
a positioner configured to advance said catheter and dose within of an artery that has been reduced by angioplasty or other procedure, said positioner also configured to position the catheter and dose between a first position and a second position, wherein in the first position the dose is positioned within the artery in a non-deployed configuration and a second position wherein the dose is in a deployed configuration and exposed through a window in the catheter for treating at least a portion of the stenosed region of the artery, said positioner configured to withdraw said catheter and dose from the artery after said radioactive dose is exposed to the stenosed region for a period of time sufficient to inhibit restenosis of the stenosed region.
30. The apparatus of claim 29 , wherein the dose is in solid form.
31. The apparatus of claim 29 , wherein the dose is in liquid form.
32. The apparatus of claim 29 , wherein the dose is in gaseous form.
33. The apparatus of claim 29 , wherein the radioactive dose for emitting radiation is positioned within the catheter, the catheter defining a housing, wherein in the first position the dose is shielded from treating the stenosed region and in the second position the housing is deployed to at least partially exposed the dose to the stenosed region of the artery.
34. The apparatus of claim 33 , wherein in the second deployed position the catheter is withdrawn relative to the dose positioned in the stenosed region to expose the stenosed region to the dose.
35. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation, wherein the radioactive dose is incorporated into a liquid for delivery;
a catheter; and
a positioner providing slidable motion of the radioactive dose within the catheter, the positioner arranged for advancing said dose within the stenosed region of an artery that has been reduced by angioplasty or other procedure, said positioner also being operatively connected to said dose for positioning the dose between a first position and a second position, wherein in the first position the dose is positioned within the artery in a non-deployed configuration and a second position wherein the dose in in a deployed configuration for treating at least a portion of the stenosed region of the artery, said positioner being operatively connected to said dose for withdrawing said dose from the artery after said radioactive dose is exposed to the stenosed region for a period of time sufficient to inhibit restenosis of the stenosed region.
36. The apparatus of claim 10 , wherein the radiation source is incorporated into a liquid for delivery.
37. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation, wherein the radioactive dose is incorporated into a liquid for delivery;
a catheter movable with respect to the dose; and
a positioner configured to advance said catheter and dose within of an artery that has been reduced by angioplasty or other procedure, said positioner also configured to position the catheter and dose between a first position and a second position, wherein in the first position the dose is positioned within the artery in a non-deployed configuration and a second position wherein the dose is in a deployed configuration for treating at least a portion of the stenosed region of the artery, said positioner configured to withdraw said catheter and dose from the artery after said radioactive dose means is exposed to the stenosed region for a period of time sufficient to inhibit restenosis of the stenosed region.
38. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation;
a catheter for delivering the radioactive dose to and removing the radioactive dose from the stenosed region of an artery that has been reduced by angioplasty or other procedure; and
a positioner configured to move the catheter and the radioactive dose with respect to one another to move the radioactive dose from a non-deployed and shielded position to a deployed and unshielded position, wherein the dose is exposed through a window in the catheter for a period of time sufficient to inhibit restenosis of the stenosed region.
39. Apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other procedure comprising:
a radioactive dose for emitting radiation, wherein the radioactive dose is incorporated into a liquid for delivery;
a catheter for delivering the radioactive dose to and removing the radioactive dose from the stenosed region of an artery that has been reduced by angioplasty or other procedure; and
a positioner configured to move the catheter and the radioactive dose with respect to one another to move the radioactive dose from a non-deployed and shielded position to a deployed and unshielded position for a period of time sufficient to inhibit restenosis of the stenosed region.
40. The apparatus of claim 10 , wherein the radiation source provides a radiation dose to the stenosed region through a window in the catheter.
41. Apparatus for treatment of a lesion site in an artery with radiation comprising:
a radioactive dose for emitting radiation, wherein the radioactive dose is incorporated into a liquid for delivery;
a catheter for delivering the radioactive dose to and removing the radioactive dose from the lesion site in the artery that has been reduced by angioplasty or other procedure; and
a positioner configured to move the catheter and the radioactive dose with respect to one another to move the radioactive dose from a non-deployed and shielded position to a deployed and unshielded position for a period of time sufficient to inhibit restenosis of the lesion site.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US08/850,073 USRE39157E1 (en) | 1991-09-05 | 1997-05-02 | Apparatus for restenosis treatment |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US07/755,480 US5302168A (en) | 1991-09-05 | 1991-09-05 | Method and apparatus for restenosis treatment |
US08/219,179 US5411466A (en) | 1991-09-05 | 1994-03-28 | Apparatus for restenosis treatment |
US08/850,073 USRE39157E1 (en) | 1991-09-05 | 1997-05-02 | Apparatus for restenosis treatment |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US08/219,179 Reissue US5411466A (en) | 1991-09-05 | 1994-03-28 | Apparatus for restenosis treatment |
Publications (1)
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USRE39157E1 true USRE39157E1 (en) | 2006-07-04 |
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Application Number | Title | Priority Date | Filing Date |
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US07/755,480 Expired - Lifetime US5302168A (en) | 1991-09-05 | 1991-09-05 | Method and apparatus for restenosis treatment |
US08/219,179 Ceased US5411466A (en) | 1991-09-05 | 1994-03-28 | Apparatus for restenosis treatment |
US08/850,073 Expired - Lifetime USRE39157E1 (en) | 1991-09-05 | 1997-05-02 | Apparatus for restenosis treatment |
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US07/755,480 Expired - Lifetime US5302168A (en) | 1991-09-05 | 1991-09-05 | Method and apparatus for restenosis treatment |
US08/219,179 Ceased US5411466A (en) | 1991-09-05 | 1994-03-28 | Apparatus for restenosis treatment |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5571169A (en) * | 1993-06-07 | 1996-11-05 | Endovascular Instruments, Inc. | Anti-stenotic method and product for occluded and partially occluded arteries |
US5484384A (en) * | 1991-01-29 | 1996-01-16 | Med Institute, Inc. | Minimally invasive medical device for providing a radiation treatment |
US5643171A (en) * | 1993-05-04 | 1997-07-01 | Neocardia, Llc | Method and apparatus for uniform radiation treatment of vascular lumens |
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US5540659A (en) * | 1993-07-15 | 1996-07-30 | Teirstein; Paul S. | Irradiation catheter and method of use |
US6045495A (en) * | 1994-01-21 | 2000-04-04 | The Trustees Fo Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
US5503613A (en) * | 1994-01-21 | 1996-04-02 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to reduce restenosis after arterial intervention |
US5707332A (en) * | 1994-01-21 | 1998-01-13 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to reduce restenosis after arterial intervention |
US6217503B1 (en) | 1994-01-21 | 2001-04-17 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
DE69527141T2 (en) | 1994-04-29 | 2002-11-07 | Scimed Life Systems Inc | STENT WITH COLLAGEN |
US5857956A (en) | 1994-06-08 | 1999-01-12 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
DE69413209T2 (en) * | 1994-06-10 | 1999-03-04 | Schneider Europ Gmbh | Medicinal device for the treatment of a part of body vessels by means of ionizing radiation |
EP0965363B1 (en) | 1994-06-24 | 2002-02-13 | Schneider (Europe) GmbH | Medical appliance for the treatment of a portion of body vessel by ionizing radiation |
US5899882A (en) | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
US6458070B1 (en) * | 1994-10-27 | 2002-10-01 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US5683345A (en) * | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US5665591A (en) * | 1994-12-06 | 1997-09-09 | Trustees Of Boston University | Regulation of smooth muscle cell proliferation |
US5616114A (en) * | 1994-12-08 | 1997-04-01 | Neocardia, Llc. | Intravascular radiotherapy employing a liquid-suspended source |
EP0805703B1 (en) * | 1995-01-17 | 1999-07-28 | Christoph Hehrlein | Balloon catheter used to prevent re-stenosis after angioplasty and process for producing a balloon catheter |
US5653683A (en) * | 1995-02-28 | 1997-08-05 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
WO1996029943A1 (en) * | 1995-03-28 | 1996-10-03 | Eli Lilly And Company | Photodynamic therapy system and method |
US5624433A (en) * | 1995-04-24 | 1997-04-29 | Interventional Technologies Inc. | Angioplasty balloon with light incisor |
US5730698A (en) * | 1995-05-09 | 1998-03-24 | Fischell; Robert E. | Balloon expandable temporary radioisotope stent system |
ATE192346T1 (en) * | 1995-06-22 | 2000-05-15 | Schneider Europ Gmbh | MEDICINAL DEVICE FOR THE TREATMENT OF A PART OF A BODY VESSEL USING IONIZATION RADIATION |
US7384423B1 (en) | 1995-07-13 | 2008-06-10 | Origin Medsystems, Inc. | Tissue dissection method |
US5833593A (en) * | 1995-11-09 | 1998-11-10 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
US5840008A (en) * | 1995-11-13 | 1998-11-24 | Localmed, Inc. | Radiation emitting sleeve catheter and methods |
US20050152950A1 (en) * | 1995-11-13 | 2005-07-14 | Saffran Bruce N. | Method and apparatus for macromolecular delivery using a coated membrane |
US5713828A (en) | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
DE69530302T2 (en) * | 1995-12-05 | 2004-01-29 | Schneider Europ Gmbh Buelach | A filament for irradiating a living body and a method for producing a filament for irradiating a living body |
US5722984A (en) * | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
US6053900A (en) * | 1996-02-16 | 2000-04-25 | Brown; Joe E. | Apparatus and method for delivering diagnostic and therapeutic agents intravascularly |
US5951458A (en) * | 1996-02-29 | 1999-09-14 | Scimed Life Systems, Inc. | Local application of oxidizing agents to prevent restenosis |
US6234951B1 (en) | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US5855546A (en) * | 1996-02-29 | 1999-01-05 | Sci-Med Life Systems | Perfusion balloon and radioactive wire delivery system |
US6099454A (en) * | 1996-02-29 | 2000-08-08 | Scimed Life Systems, Inc. | Perfusion balloon and radioactive wire delivery system |
US5882290A (en) * | 1996-02-29 | 1999-03-16 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US6736769B2 (en) | 1996-04-17 | 2004-05-18 | Olivier Bertrand | Radioactivity local delivery system |
US5916143A (en) * | 1996-04-30 | 1999-06-29 | Apple; Marc G. | Brachytherapy catheter system |
US6958059B2 (en) | 1996-05-20 | 2005-10-25 | Medtronic Ave, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
US5871436A (en) * | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
US5833682A (en) * | 1996-08-26 | 1998-11-10 | Illumenex Corporation | Light delivery system with blood flushing capability |
US5910101A (en) * | 1996-08-29 | 1999-06-08 | Advanced Cardiovascular Systems, Inc. | Device for loading and centering a vascular radiation therapy source |
US5782740A (en) * | 1996-08-29 | 1998-07-21 | Advanced Cardiovascular Systems, Inc. | Radiation dose delivery catheter with reinforcing mandrel |
US5947924A (en) * | 1996-09-13 | 1999-09-07 | Angiorad, L.L.C. | Dilatation/centering catheter used for the treatment of stenosis or other constriction in a bodily passageway and method thereof |
US5924973A (en) | 1996-09-26 | 1999-07-20 | The Trustees Of Columbia University In The City Of New York | Method of treating a disease process in a luminal structure |
US5797948A (en) * | 1996-10-03 | 1998-08-25 | Cordis Corporation | Centering balloon catheter |
AU1275997A (en) * | 1996-10-11 | 1998-05-11 | Transvascular, Inc. | Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures |
US5782741A (en) * | 1996-11-12 | 1998-07-21 | Guidant Coropration | Two-stage treatment wire |
US6261320B1 (en) | 1996-11-21 | 2001-07-17 | Radiance Medical Systems, Inc. | Radioactive vascular liner |
US6117064A (en) * | 1997-01-06 | 2000-09-12 | Apple; Marc G. | Catheter system |
US5873811A (en) * | 1997-01-10 | 1999-02-23 | Sci-Med Life Systems | Composition containing a radioactive component for treatment of vessel wall |
US5910102A (en) * | 1997-01-10 | 1999-06-08 | Scimed Life Systems, Inc. | Conversion of beta radiation to gamma radiation for intravascular radiation therapy |
US5879282A (en) | 1997-01-21 | 1999-03-09 | Cordis A Johnson And Johnson Company | Catheter having an expandable radioactive source |
US5863285A (en) * | 1997-01-30 | 1999-01-26 | Cordis Corporation | Balloon catheter with radioactive means |
US6458069B1 (en) | 1998-02-19 | 2002-10-01 | Endology, Inc. | Multi layer radiation delivery balloon |
US5782742A (en) * | 1997-01-31 | 1998-07-21 | Cardiovascular Dynamics, Inc. | Radiation delivery balloon |
US6491619B1 (en) | 1997-01-31 | 2002-12-10 | Endologix, Inc | Radiation delivery catheters and dosimetry methods |
CA2281519A1 (en) | 1997-02-19 | 1998-08-27 | Condado Medical Devices Corporation | Multi-purpose catheters, catheter systems, and radiation treatment |
FR2759914B1 (en) * | 1997-02-27 | 1999-07-30 | Concept Medical Service | DEVICE USED IN CURIETHERAPY |
AT405136B (en) * | 1997-02-27 | 1999-05-25 | Oesterr Forsch Seibersdorf | DEVICE FOR THE INTRAVASCULAR TREATMENT OF RESTENOSES |
US6312374B1 (en) | 1997-03-06 | 2001-11-06 | Progenix, Llc | Radioactive wire placement catheter |
US5865720A (en) * | 1997-03-06 | 1999-02-02 | Scimed Life Systems, Inc. | Expandable and retrievable radiation delivery system |
US6676590B1 (en) | 1997-03-06 | 2004-01-13 | Scimed Life Systems, Inc. | Catheter system having tubular radiation source |
US6110097A (en) * | 1997-03-06 | 2000-08-29 | Scimed Life Systems, Inc. | Perfusion balloon catheter with radioactive source |
US6059713A (en) * | 1997-03-06 | 2000-05-09 | Scimed Life Systems, Inc. | Catheter system having tubular radiation source with movable guide wire |
US6059812A (en) | 1997-03-21 | 2000-05-09 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US6309339B1 (en) * | 1997-03-28 | 2001-10-30 | Endosonics Corporation | Intravascular radiation delivery device |
US6033357A (en) * | 1997-03-28 | 2000-03-07 | Navius Corporation | Intravascular radiation delivery device |
ATE258447T1 (en) | 1997-04-26 | 2004-02-15 | Univ Karlsruhe | RADIONUCLIDE MICROPARTICLES IN COMPOUND WITH ELASTOMERIC TUBING FOR ENDOVASCULAR THERAPY |
DE19724223C1 (en) * | 1997-04-30 | 1998-12-24 | Schering Ag | Production of radioactive coated stent, especially at point of use |
DE19718339A1 (en) * | 1997-04-30 | 1998-11-12 | Schering Ag | Polymer coated stents, processes for their manufacture and their use for restenosis prophylaxis |
US6210312B1 (en) | 1997-05-20 | 2001-04-03 | Advanced Cardiovascular Systems, Inc. | Catheter and guide wire assembly for delivery of a radiation source |
US6200307B1 (en) * | 1997-05-22 | 2001-03-13 | Illumenex Corporation | Treatment of in-stent restenosis using cytotoxic radiation |
US6019718A (en) * | 1997-05-30 | 2000-02-01 | Scimed Life Systems, Inc. | Apparatus for intravascular radioactive treatment |
US5906573A (en) * | 1997-07-18 | 1999-05-25 | Radiomed Corporation | Radioactive surgical fastening devices and methods of making same |
FR2764503B1 (en) * | 1997-06-17 | 1999-10-01 | Braun Celsa Sa | DEVICE FOR TEMPORARILY IMPLANTABLE BLOOD FILTRATION IN A BLOOD VESSEL |
US5993374A (en) * | 1997-06-17 | 1999-11-30 | Radiance Medical Systems, Inc. | Microcapsules for site-specific delivery |
US6024690A (en) * | 1997-07-01 | 2000-02-15 | Endosonics Corporation | Radiation source with delivery wire |
US5902299A (en) * | 1997-07-29 | 1999-05-11 | Jayaraman; Swaminathan | Cryotherapy method for reducing tissue injury after balloon angioplasty or stent implantation |
AU738093B2 (en) | 1997-09-11 | 2001-09-06 | Marc G. Apple | Medical radiation treatment delivery apparatus |
US5947890A (en) * | 1997-09-19 | 1999-09-07 | Spencer; Robert H. | Apparatus and improved method for safely dispensing and delivering liquid radiation for intraluminal radiation therapy |
EP1019145A1 (en) | 1997-09-23 | 2000-07-19 | United States Surgical Corporation | Source wire for radiation treatment |
ATE227145T1 (en) | 1997-09-26 | 2002-11-15 | Schneider Europ Gmbh | BALLOON CATHETER INFLATED WITH CARBON DIOXIDE FOR RADIOTHERAPY |
US6419621B1 (en) | 1997-10-24 | 2002-07-16 | Radiomed Corporation | Coiled brachytherapy device |
US6030333A (en) * | 1997-10-24 | 2000-02-29 | Radiomed Corporation | Implantable radiotherapy device |
US6273850B1 (en) | 1997-10-29 | 2001-08-14 | Medtronic Ave, Inc. | Device for positioning a radiation source at a stenosis treatment site |
US6264596B1 (en) * | 1997-11-03 | 2001-07-24 | Meadox Medicals, Inc. | In-situ radioactive medical device |
US5851171A (en) | 1997-11-04 | 1998-12-22 | Advanced Cardiovascular Systems, Inc. | Catheter assembly for centering a radiation source within a body lumen |
US6048299A (en) * | 1997-11-07 | 2000-04-11 | Radiance Medical Systems, Inc. | Radiation delivery catheter |
AU749577B2 (en) | 1997-11-07 | 2002-06-27 | Gmp/Vascular, Inc. | Device for intravascular delivery of beta emitting isotopes |
AU737378B2 (en) | 1997-12-05 | 2001-08-16 | Cook Incorporated | Medical radiation treatment device |
US6129658A (en) | 1997-12-10 | 2000-10-10 | Varian Associates, Inc. | Method and apparatus creating a radioactive layer on a receiving substrate for in vivo implantation |
US5957829A (en) * | 1997-12-17 | 1999-09-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for radiotherapy using a radioactive source wire having a magnetic insert |
US6149574A (en) * | 1997-12-19 | 2000-11-21 | Radiance Medical Systems, Inc. | Dual catheter radiation delivery system |
AU2209599A (en) * | 1997-12-31 | 1999-07-19 | Pharmasonics, Inc. | Methods and systems for the inhibition of vascular hyperplasia |
US5961439A (en) * | 1998-05-06 | 1999-10-05 | United States Surgical Corporation | Device and method for radiation therapy |
AU2320299A (en) | 1998-01-14 | 1999-08-02 | United States Surgical Corporation | Device and method for radiation therapy |
US6077413A (en) | 1998-02-06 | 2000-06-20 | The Cleveland Clinic Foundation | Method of making a radioactive stent |
US6159140A (en) * | 1998-02-17 | 2000-12-12 | Advanced Cardiovascular Systems | Radiation shielded catheter for delivering a radioactive source and method of use |
WO1999040962A1 (en) | 1998-02-17 | 1999-08-19 | Advanced Cardiovascular Systems, Inc. | Radiation centering catheter with blood perfusion capability |
US6224535B1 (en) | 1998-02-17 | 2001-05-01 | Advanced Cardiovascular Systems, Inc. | Radiation centering catheters |
US6159139A (en) * | 1998-02-17 | 2000-12-12 | Advanced Cardiovascular Systems Inc. | Radiation delivery catheter with a spring wire centering mechanism |
WO1999042177A1 (en) | 1998-02-19 | 1999-08-26 | Radiance Medical Systems, Inc. | Radioactive stent |
US6338709B1 (en) | 1998-02-19 | 2002-01-15 | Medtronic Percusurge, Inc. | Intravascular radiation therapy device and method of use |
US6013019A (en) * | 1998-04-06 | 2000-01-11 | Isostent, Inc. | Temporary radioisotope stent |
DE19819426A1 (en) | 1998-04-30 | 1999-11-11 | Christoph Hehrlein | Catheters and vascular supports, in particular for combined radioactive radiation and medication therapy and methods for their production |
US6074339A (en) * | 1998-05-07 | 2000-06-13 | Medtronic Ave, Inc. | Expandable braid device and method for radiation treatment |
US6050930A (en) * | 1998-06-02 | 2000-04-18 | Teirstein; Paul S. | Irradiation catheter with expandable source |
JP3781331B2 (en) * | 1998-06-05 | 2006-05-31 | 独立行政法人 日本原子力研究開発機構 | Method for producing xenon-133 for preventing vascular restenosis |
US7326178B1 (en) | 1998-06-22 | 2008-02-05 | Origin Medsystems, Inc. | Vessel retraction device and method |
US6830546B1 (en) | 1998-06-22 | 2004-12-14 | Origin Medsystems, Inc. | Device and method for remote vessel ligation |
US6976957B1 (en) | 1998-06-22 | 2005-12-20 | Origin Medsystems, Inc. | Cannula-based surgical instrument and method |
EP0979635A2 (en) | 1998-08-12 | 2000-02-16 | Origin Medsystems, Inc. | Tissue dissector apparatus |
US6413203B1 (en) | 1998-09-16 | 2002-07-02 | Scimed Life Systems, Inc. | Method and apparatus for positioning radioactive fluids within a body lumen |
IL126341A0 (en) * | 1998-09-24 | 1999-05-09 | Medirad I R T Ltd | Radiation delivery devices and methods of making same |
US6607476B1 (en) | 1998-10-01 | 2003-08-19 | University Of Iowa Research Foundation | Brachytherapy positioning system |
US6605030B2 (en) | 1998-11-09 | 2003-08-12 | The Trustees Of Columbia University In The City Of New York | Apparatus and method for treating a disease process in a luminal structure |
US6120533A (en) * | 1998-11-13 | 2000-09-19 | Isostent, Inc. | Stent delivery system for a radioisotope stent |
US6471631B1 (en) * | 1998-11-27 | 2002-10-29 | Syntheon, Llc | Implantable radiation therapy device having controllable radiation emission |
US6402676B2 (en) | 1999-01-20 | 2002-06-11 | Advanced Cardiovascular Systems, Inc. | Tip configuration for radiation source wires |
US6224536B1 (en) | 1999-02-08 | 2001-05-01 | Advanced Cardiovascular Systems | Method for delivering radiation therapy to an intravascular site in a body |
US6196963B1 (en) | 1999-03-02 | 2001-03-06 | Medtronic Ave, Inc. | Brachytherapy device assembly and method of use |
US6200256B1 (en) | 1999-03-17 | 2001-03-13 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
US6146323A (en) * | 1999-05-14 | 2000-11-14 | Isostent, Inc. | Delivery catheter for a radioisotope stent |
US6561966B1 (en) * | 1999-06-04 | 2003-05-13 | Radi Medical Technologies Ab | Device for X-ray dosage control |
US6387116B1 (en) | 1999-06-30 | 2002-05-14 | Pharmasonics, Inc. | Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts |
US6361554B1 (en) | 1999-06-30 | 2002-03-26 | Pharmasonics, Inc. | Methods and apparatus for the subcutaneous delivery of acoustic vibrations |
US7022088B2 (en) * | 1999-08-05 | 2006-04-04 | Broncus Technologies, Inc. | Devices for applying energy to tissue |
US20030070676A1 (en) * | 1999-08-05 | 2003-04-17 | Cooper Joel D. | Conduits having distal cage structure for maintaining collateral channels in tissue and related methods |
US7422563B2 (en) * | 1999-08-05 | 2008-09-09 | Broncus Technologies, Inc. | Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow |
US7815590B2 (en) * | 1999-08-05 | 2010-10-19 | Broncus Technologies, Inc. | Devices for maintaining patency of surgically created channels in tissue |
US6632223B1 (en) * | 2000-03-30 | 2003-10-14 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
US6582417B1 (en) * | 1999-09-22 | 2003-06-24 | Advanced Cardiovascular Systems, Inc. | Methods and apparatuses for radiation treatment |
US6605031B1 (en) | 1999-09-22 | 2003-08-12 | Advanced Cardiovascular Systems, Inc. | Stepped centering balloon for optimal radiation delivery |
US6352501B1 (en) | 1999-09-23 | 2002-03-05 | Scimed Life Systems, Inc. | Adjustable radiation source |
US6464626B1 (en) * | 1999-09-30 | 2002-10-15 | Advanced Cardiovascular Systems, Inc. | Catheter assembly incorporating radiation shielding and related method of use |
US6203485B1 (en) | 1999-10-07 | 2001-03-20 | Scimed Life Systems, Inc. | Low attenuation guide wire for intravascular radiation delivery |
US6398709B1 (en) | 1999-10-19 | 2002-06-04 | Scimed Life Systems, Inc. | Elongated member for intravascular delivery of radiation |
US6436026B1 (en) | 1999-10-22 | 2002-08-20 | Radiomed Corporation | Flexible, continuous, axially elastic interstitial brachytherapy source |
US6368266B1 (en) | 1999-11-12 | 2002-04-09 | Vascular Architects, Inc. | Medical irradiation assembly and method |
US6575887B1 (en) | 1999-11-18 | 2003-06-10 | Epsilon Medical, Inc. | Devices for the inhibition or suppression of cellular proliferation in tubular body structures |
AU2738001A (en) | 1999-12-28 | 2001-07-09 | Apple, Marc G. | Enhanced energy radiotherapy balloon catheter |
JP2003528657A (en) | 2000-01-07 | 2003-09-30 | インターヴェンショナル セラピーズ エルエルシー | Energy filter system |
US7994449B2 (en) | 2000-02-16 | 2011-08-09 | Advanced Cardiovascular Systems, Inc. | Square-wave laser bonding |
US7163504B1 (en) | 2000-02-16 | 2007-01-16 | Advanced Cardiovascular Systems, Inc. | Multi-lumen fluted balloon radiation centering catheter |
US6416457B1 (en) | 2000-03-09 | 2002-07-09 | Scimed Life Systems, Inc. | System and method for intravascular ionizing tandem radiation therapy |
US6302865B1 (en) | 2000-03-13 | 2001-10-16 | Scimed Life Systems, Inc. | Intravascular guidewire with perfusion lumen |
US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
US20070055367A1 (en) * | 2000-03-15 | 2007-03-08 | Orbus Medical Technologies, Inc. | Medical device with coating that promotes endothelial cell adherence and differentiation |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US8460367B2 (en) * | 2000-03-15 | 2013-06-11 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US20070141107A1 (en) * | 2000-03-15 | 2007-06-21 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
CA2400319C (en) * | 2000-03-15 | 2008-09-16 | Orbus Medical Technologies Inc. | Coating that promotes endothelial cell adherence |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US6994688B2 (en) * | 2000-05-18 | 2006-02-07 | Theragenics Corporation | Catheter attachment and catheter for brachytherapy |
US6508784B1 (en) | 2000-05-19 | 2003-01-21 | Yan-Ho Shu | Balloon catheter having adjustable centering capabilities and methods thereof |
US20040158317A1 (en) * | 2000-07-18 | 2004-08-12 | Pharmasonics, Inc. | Coated stent with ultrasound therapy |
WO2002007795A2 (en) * | 2000-07-24 | 2002-01-31 | Jeffrey Grayzel | Stiffened balloon catheter for dilatation and stenting |
JP4538918B2 (en) | 2000-08-02 | 2010-09-08 | 株式会社カネカ | Medical catheter for treating part of a body tube with ionizing radiation |
US6390967B1 (en) | 2000-09-14 | 2002-05-21 | Xoft Microtube, Inc. | Radiation for inhibiting hyperplasia after intravascular intervention |
US6416492B1 (en) | 2000-09-28 | 2002-07-09 | Scimed Life Systems, Inc. | Radiation delivery system utilizing intravascular ultrasound |
US6558313B1 (en) | 2000-11-17 | 2003-05-06 | Embro Corporation | Vein harvesting system and method |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
US6641607B1 (en) | 2000-12-29 | 2003-11-04 | Advanced Cardiovascular Systems, Inc. | Double tube stent |
US6764505B1 (en) * | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US6537195B2 (en) | 2001-05-07 | 2003-03-25 | Xoft, Microtube, Inc. | Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia |
US7041046B2 (en) * | 2001-05-07 | 2006-05-09 | Xoft, Inc. | Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia |
US7862495B2 (en) * | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
US6673006B2 (en) * | 2001-06-15 | 2004-01-06 | Proxima Therapeutics, Inc. | Tissue positioning apparatus and method for protecting tissue from radiotherapy |
US7493162B2 (en) * | 2001-06-15 | 2009-02-17 | Cardiac Pacemakers, Inc. | Pulmonary vein stent for treating atrial fibrillation |
US6679860B2 (en) | 2001-06-19 | 2004-01-20 | Medtronic Ave, Inc. | Intraluminal therapy catheter with inflatable helical member and methods of use |
US6656216B1 (en) * | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
US7056274B2 (en) | 2001-07-13 | 2006-06-06 | Apple Marc G | Catheter with concentric balloons for radiogas delivery and booster radiosources for use therewith |
US6488628B1 (en) | 2001-07-31 | 2002-12-03 | Scimed Life Systems, Inc. | Method for ultrasonically profiling the distribution of an administered medicament |
WO2004000092A2 (en) * | 2001-08-13 | 2003-12-31 | Cryovascular Systems, Inc. | Cryotherapy methods for treating vessel dissections and side branch occlusion |
US6786900B2 (en) * | 2001-08-13 | 2004-09-07 | Cryovascular Systems, Inc. | Cryotherapy methods for treating vessel dissections and side branch occlusion |
US7708712B2 (en) | 2001-09-04 | 2010-05-04 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
AU2003241515A1 (en) | 2002-05-20 | 2003-12-12 | Orbus Medical Technologies Inc. | Drug eluting implantable medical device |
CA2497919C (en) * | 2002-09-10 | 2015-11-03 | Curay Medical, Inc. | Brachtherapy apparatus |
US8328710B2 (en) * | 2002-11-06 | 2012-12-11 | Senorx, Inc. | Temporary catheter for biopsy site tissue fixation |
US6923754B2 (en) * | 2002-11-06 | 2005-08-02 | Senorx, Inc. | Vacuum device and method for treating tissue adjacent a body cavity |
US7169178B1 (en) | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
WO2004098523A2 (en) * | 2003-04-30 | 2004-11-18 | The Board Of Trustees At The University Of Illinois At Chicago | Intraocular brachytherapy device and method |
US7632288B2 (en) | 2003-05-12 | 2009-12-15 | Boston Scientific Scimed, Inc. | Cutting balloon catheter with improved pushability |
US7758604B2 (en) | 2003-05-29 | 2010-07-20 | Boston Scientific Scimed, Inc. | Cutting balloon catheter with improved balloon configuration |
US8308682B2 (en) | 2003-07-18 | 2012-11-13 | Broncus Medical Inc. | Devices for maintaining patency of surgically created channels in tissue |
US8002740B2 (en) * | 2003-07-18 | 2011-08-23 | Broncus Technologies, Inc. | Devices for maintaining patency of surgically created channels in tissue |
US7780626B2 (en) * | 2003-08-08 | 2010-08-24 | Boston Scientific Scimed, Inc. | Catheter shaft for regulation of inflation and deflation |
US7887557B2 (en) * | 2003-08-14 | 2011-02-15 | Boston Scientific Scimed, Inc. | Catheter having a cutting balloon including multiple cavities or multiple channels |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
EP2671540B1 (en) | 2004-03-10 | 2019-10-30 | Orbusneich Medical Pte. Ltd | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US7754047B2 (en) | 2004-04-08 | 2010-07-13 | Boston Scientific Scimed, Inc. | Cutting balloon catheter and method for blade mounting |
US7566319B2 (en) | 2004-04-21 | 2009-07-28 | Boston Scientific Scimed, Inc. | Traction balloon |
WO2005107817A2 (en) | 2004-04-30 | 2005-11-17 | Orbus Medical Technologies, Inc. | Medical device with coating for capturing genetically-altered cells and methods of using same |
US8409167B2 (en) | 2004-07-19 | 2013-04-02 | Broncus Medical Inc | Devices for delivering substances through an extra-anatomic opening created in an airway |
US8267917B2 (en) * | 2004-07-27 | 2012-09-18 | University Of Southern California | Percutaneously retrievable stent assembly with fluid draining capability |
US7662082B2 (en) | 2004-11-05 | 2010-02-16 | Theragenics Corporation | Expandable brachytherapy device |
US8038691B2 (en) | 2004-11-12 | 2011-10-18 | Boston Scientific Scimed, Inc. | Cutting balloon catheter having flexible atherotomes |
US7291158B2 (en) * | 2004-11-12 | 2007-11-06 | Boston Scientific Scimed, Inc. | Cutting balloon catheter having a segmented blade |
US9050393B2 (en) | 2005-02-08 | 2015-06-09 | Bruce N. Saffran | Medical devices and methods for modulation of physiology using device-based surface chemistry |
US20060235504A1 (en) * | 2005-02-10 | 2006-10-19 | Clear Vascular, Inc. | Methods and apparatus for treatment of luminal hyperplasia |
US8834338B2 (en) | 2005-02-10 | 2014-09-16 | Snip Holdings, Inc. | Dosimetry implant for treating restenosis and hyperplasia |
US8114264B2 (en) * | 2005-02-10 | 2012-02-14 | Brookhaven Science Associates | Method of electroplating a conversion electron emitting source on implant |
US20060184191A1 (en) | 2005-02-11 | 2006-08-17 | Boston Scientific Scimed, Inc. | Cutting balloon catheter having increased flexibility regions |
US7618362B2 (en) * | 2005-03-28 | 2009-11-17 | Boston Scientific Scimed, Inc. | Spacer apparatus for radiation and ablation therapy |
WO2007053823A2 (en) * | 2005-10-31 | 2007-05-10 | Biolucent, Inc. | Brachytherapy apparatus and methods of using same |
US7887476B2 (en) | 2005-11-10 | 2011-02-15 | Cianna Medical, Inc. | Helical brachytherapy apparatus and methods of using same |
US7862496B2 (en) * | 2005-11-10 | 2011-01-04 | Cianna Medical, Inc. | Brachytherapy apparatus and methods for using them |
US8273006B2 (en) * | 2005-11-18 | 2012-09-25 | Senorx, Inc. | Tissue irradiation |
US7465268B2 (en) | 2005-11-18 | 2008-12-16 | Senorx, Inc. | Methods for asymmetrical irradiation of a body cavity |
US7413539B2 (en) * | 2005-11-18 | 2008-08-19 | Senorx, Inc. | Treatment of a body cavity |
US8137256B2 (en) * | 2005-12-16 | 2012-03-20 | Portola Medical, Inc. | Brachytherapy apparatus |
US20070270627A1 (en) * | 2005-12-16 | 2007-11-22 | North American Scientific | Brachytherapy apparatus for asymmetrical body cavities |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US7862497B2 (en) * | 2006-04-21 | 2011-01-04 | Portola Medical, Inc. | Brachytherapy device having seed tubes with individually-settable tissue spacings |
US8069814B2 (en) | 2006-05-04 | 2011-12-06 | Advanced Cardiovascular Systems, Inc. | Stent support devices |
US20090143777A1 (en) * | 2006-05-23 | 2009-06-04 | Andrew Pacey | Apparatus and method for treating tissue such as tumours |
US9770230B2 (en) | 2006-06-01 | 2017-09-26 | Maquet Cardiovascular Llc | Endoscopic vessel harvesting system components |
CA2653617C (en) * | 2006-06-02 | 2016-08-30 | Cianna Medical, Inc. | Expandable brachytherapy apparatus |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
ATE514457T1 (en) * | 2006-10-08 | 2011-07-15 | Cianna Medical Inc | EXPANDABLE BRACHYTHERAPY DEVICE |
US8287442B2 (en) * | 2007-03-12 | 2012-10-16 | Senorx, Inc. | Radiation catheter with multilayered balloon |
US8740873B2 (en) * | 2007-03-15 | 2014-06-03 | Hologic, Inc. | Soft body catheter with low friction lumen |
US20080228023A1 (en) * | 2007-03-15 | 2008-09-18 | Senorx, Inc. | Soft body catheter with low friction lumen |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US20090054874A1 (en) * | 2007-08-23 | 2009-02-26 | C. R. Bard, Inc. | Multi-lumen catheter including a lumen having a variable cross sectional area |
WO2009079170A2 (en) * | 2007-12-16 | 2009-06-25 | Cianna Medical, Inc. | Expandable brachytherapy apparatus and methods for using them |
KR101634983B1 (en) * | 2008-01-07 | 2016-07-01 | 살루타리스 메디컬 디바이스즈, 인코퍼레이티드 | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US8360950B2 (en) * | 2008-01-24 | 2013-01-29 | Senorx, Inc. | Multilumen brachytherapy balloon catheter |
US20100010287A1 (en) * | 2008-07-09 | 2010-01-14 | Senorx, Inc. | Brachytherapy device with one or more toroidal balloons |
US8636635B2 (en) * | 2008-08-18 | 2014-01-28 | Cianna Medical, Inc. | Brachytherapy apparatus, systems, and methods for using them |
US9248311B2 (en) | 2009-02-11 | 2016-02-02 | Hologic, Inc. | System and method for modifying a flexibility of a brachythereapy catheter |
US9579524B2 (en) | 2009-02-11 | 2017-02-28 | Hologic, Inc. | Flexible multi-lumen brachytherapy device |
US10207126B2 (en) | 2009-05-11 | 2019-02-19 | Cytyc Corporation | Lumen visualization and identification system for multi-lumen balloon catheter |
US8814775B2 (en) * | 2010-03-18 | 2014-08-26 | Cianna Medical, Inc. | Expandable brachytherapy apparatus and methods for using them |
US9883919B2 (en) | 2010-07-21 | 2018-02-06 | Cianna Medical, Inc. | Brachytherapy apparatus, systems, and methods for using them |
US9352172B2 (en) | 2010-09-30 | 2016-05-31 | Hologic, Inc. | Using a guide member to facilitate brachytherapy device swap |
US9067063B2 (en) | 2010-11-03 | 2015-06-30 | Cianna Medical, Inc. | Expandable brachytherapy apparatus and methods for using them |
US10342992B2 (en) | 2011-01-06 | 2019-07-09 | Hologic, Inc. | Orienting a brachytherapy applicator |
US8709034B2 (en) | 2011-05-13 | 2014-04-29 | Broncus Medical Inc. | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
EP2706940B1 (en) | 2011-05-13 | 2016-12-14 | Broncus Medical, Inc. | Methods and devices for ablation of tissue |
WO2013078235A1 (en) | 2011-11-23 | 2013-05-30 | Broncus Medical Inc | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
US10086213B2 (en) | 2015-04-23 | 2018-10-02 | Mark A. D'Andrea | Mobile gynecological balloon devices and methods |
US11832877B2 (en) | 2017-04-03 | 2023-12-05 | Broncus Medical Inc. | Electrosurgical access sheath |
WO2020248073A1 (en) * | 2019-06-13 | 2020-12-17 | The Royal Institution For The Advancement Of Learning / Mcgill University | Radiation shields for brachytherapy |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168092A (en) * | 1961-06-15 | 1965-02-02 | Silverman Daniel | Medical probing instrument having flexible, extrudable tubing adapted to be extraverted under pressure into a body cavity |
US3324847A (en) * | 1964-06-01 | 1967-06-13 | Elias G Zoumboulis | Radioactive catheter |
US4202323A (en) * | 1978-04-28 | 1980-05-13 | Herz Matthew L | Drug activation by radiation |
US4434788A (en) * | 1980-08-11 | 1984-03-06 | Yamasa Shoyu Kabushiki Kaisha | Enhancer of anti-tumor effect |
US4588395A (en) * | 1978-03-10 | 1986-05-13 | Lemelson Jerome H | Catheter and method |
US4697575A (en) * | 1984-11-21 | 1987-10-06 | Henry Ford Hospital | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
US4733665A (en) * | 1985-11-07 | 1988-03-29 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4878492A (en) * | 1987-10-08 | 1989-11-07 | C. R. Bard, Inc. | Laser balloon catheter |
US4881938A (en) * | 1984-01-12 | 1989-11-21 | Hooft Eric T Van | Method and an apparatus for treating a part of the body with radioactive material |
US5019075A (en) * | 1984-10-24 | 1991-05-28 | The Beth Israel Hospital | Method and apparatus for angioplasty |
US5059166A (en) * | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
US5213561A (en) * | 1990-09-06 | 1993-05-25 | Weinstein Joseph S | Method and devices for preventing restenosis after angioplasty |
-
1991
- 1991-09-05 US US07/755,480 patent/US5302168A/en not_active Expired - Lifetime
-
1994
- 1994-03-28 US US08/219,179 patent/US5411466A/en not_active Ceased
-
1997
- 1997-05-02 US US08/850,073 patent/USRE39157E1/en not_active Expired - Lifetime
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168092A (en) * | 1961-06-15 | 1965-02-02 | Silverman Daniel | Medical probing instrument having flexible, extrudable tubing adapted to be extraverted under pressure into a body cavity |
US3324847A (en) * | 1964-06-01 | 1967-06-13 | Elias G Zoumboulis | Radioactive catheter |
US4588395A (en) * | 1978-03-10 | 1986-05-13 | Lemelson Jerome H | Catheter and method |
US4202323A (en) * | 1978-04-28 | 1980-05-13 | Herz Matthew L | Drug activation by radiation |
US4434788A (en) * | 1980-08-11 | 1984-03-06 | Yamasa Shoyu Kabushiki Kaisha | Enhancer of anti-tumor effect |
US4881938A (en) * | 1984-01-12 | 1989-11-21 | Hooft Eric T Van | Method and an apparatus for treating a part of the body with radioactive material |
US5019075A (en) * | 1984-10-24 | 1991-05-28 | The Beth Israel Hospital | Method and apparatus for angioplasty |
US4697575A (en) * | 1984-11-21 | 1987-10-06 | Henry Ford Hospital | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
US4815449A (en) * | 1984-11-21 | 1989-03-28 | Horowitz Bruce S | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
US4733665B1 (en) * | 1985-11-07 | 1994-01-11 | Expandable Grafts Partnership | Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft |
US4733665A (en) * | 1985-11-07 | 1988-03-29 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4878492A (en) * | 1987-10-08 | 1989-11-07 | C. R. Bard, Inc. | Laser balloon catheter |
US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
US5059166A (en) * | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5213561A (en) * | 1990-09-06 | 1993-05-25 | Weinstein Joseph S | Method and devices for preventing restenosis after angioplasty |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8999364B2 (en) | 2004-06-15 | 2015-04-07 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
US9908143B2 (en) | 2008-06-20 | 2018-03-06 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US10646359B2 (en) | 2008-06-20 | 2020-05-12 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US10893960B2 (en) | 2008-06-20 | 2021-01-19 | Razmodics Llc | Stent fabrication via tubular casting processes |
US11931484B2 (en) | 2008-06-20 | 2024-03-19 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
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US5302168A (en) | 1994-04-12 |
US5411466A (en) | 1995-05-02 |
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