US9808647B2 - Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity - Google Patents
Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity Download PDFInfo
- Publication number
- US9808647B2 US9808647B2 US13/801,750 US201313801750A US9808647B2 US 9808647 B2 US9808647 B2 US 9808647B2 US 201313801750 A US201313801750 A US 201313801750A US 9808647 B2 US9808647 B2 US 9808647B2
- Authority
- US
- United States
- Prior art keywords
- emr
- catheter
- catheter body
- medical device
- sterilizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/084—Visible light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0019—Cleaning catheters or the like, e.g. for reuse of the device, for avoiding replacement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/0028—Multi-lumen catheters with stationary elements characterized by features relating to at least one lumen located at the proximal part of the catheter, e.g. alterations in lumen shape or valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
Definitions
- This disclosure generally relates to methods and apparatuses to inactivate infectious agents on a catheter while residing in a patient's body cavity.
- the disclosure is a medical device assembly that utilizes non-ultraviolet sterilizing electromagnetic radiation (EMR) at a high enough intensity to reduce or eliminate infectious agents in, on, and around a catheter while it resides inside a body cavity.
- EMR non-ultraviolet sterilizing electromagnetic radiation
- Catheters are commonly used as channels to inject medications or retrieve fluid samples in a patient.
- Each catheter comprises a tube, usually derived from plastic or other polymers, such as silicone, polyurethane, and the like, that is inserted into an area of the body and may contain one or more separate lines in which these fluids may be delivered or retrieved.
- a “lumen” designates a pathway in the catheter that goes from outside the body to inside the body.
- Catheters are used in various applications, including intravascularly, urologically, gastrointestinally, ophthalmically, within the respiratory tract, within cranial space, within the spinal column, and the like. In all cases, the catheter is placed inside of a space in the body where the catheter resides, herein referred to as a “body cavity”.
- Infectious agents can include bacteria, fungi, viruses, or the like that enter the body and lead to illness of a patient. Depending on the location of the catheter placement, these infections can arise in the form of urinary tract infections, blood stream infections, soft tissue infection, and the like.
- Catheter related infections are a large problem in medicine, leading to high morbidity and mortality rates.
- Current methods of reducing or eliminating the number of infectious agents in and on a catheter are of low efficacy.
- catheters will be removed if they are suspected to be harboring infectious agents, increasing both the cost associated with treatment and patient discomfort.
- Various methods to deter or eliminate growth of infectious agents in catheters have been attempted, such as using sterile handling techniques, antibiotics, and replacing the catheter when an infection is suspected. Despite these techniques, infections resulting from catheters remain a major problem. According to the Centers for Disease Control and Prevention, over 31,000 people died specifically from catheter-related bloodstream infections in 2010. These infections, along with urinary tract infections, gastrointestinal infections, and other infections from catheters, increase both medical costs and patient discomfort.
- UV light ultraviolet light
- EMR sterilizing electromagnetic radiation
- MRSA methicillin-resistance staphylococcus aureus
- Biofilm consists of extracellular polymeric material created by microorganisms after they adhere to a surface. This biofilm facilitates the growth of infectious agents and is very difficult to break down once it has begun to grow.
- infectious agents can result from agents outside the patient (at the point of access as the catheter crosses the skin or from the catheter hub) or from inside the patient, wherein infectious agents already in the body attach to the surface of the catheter and proliferate.
- Scientific literature suggests that approximately 65% of CRI's come from infectious agents residing on the skin of the patient (S. ⁇ ncü, Central Venous Catheter—Related Infections: An Overview with Special Emphasis on Diagnosis, Prevention and Management. The Internet Journal of Anesthesiology. 2003 Volume 7 Number 1). These agents travel down the outside of the catheter and colonize the catheter tip. For short term catheterization, this is believed to be the most likely mechanism of infection (Crump. Intravascular Catheter-Associated Infections.
- EMR in the range of 380-900 nm has been shown to be effective in killing infectious agents.
- Research done by a group at the University of Strathclyde shows that light in this range is effective in killing surface bacteria in burn wards without harming the patients (Environmental decontamination of a hospital isolation room using high-intensity light. J Hosp Infect. 2010 November;76(3):247-51).
- Published patent application 2010/0246169 written by the members who conducted the study, utilizes ambient lighting to disinfect a large surrounding area. The mechanism proposed by the team suggests that light in this range leads to photosensitization of endogenous porphyrins within the bacteria, which causes the creation of singlet oxygen, leading to the death of the bacteria. (Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array. Appl Environ Microbiol. 2009 April;75(7): 1932-7).
- the assembly comprises an electromagnetic radiation (EMR) source for providing non-ultraviolet, sterilizing EMR having intensity sufficient to inactivate one or more infectious agents.
- EMR electromagnetic radiation
- This catheter has an elongate catheter body with at least one internal lumen, a coupling end, and a distal end tip. This distal end tip is insertable into the cavity of the patient's body, wherein the catheter body directs both the fluid and the sterilizing EMR axially through the catheter body for delivery into the patient's body at the distal end tip.
- An optical element disposed within the catheter body acts conducive to the axial propagation of the sterilizing EMR through the catheter body.
- the optical element or another optical element also may be disposed to act conducive to propagation of sterilizing EMR through at least one coupling element to connect the EMR component to the insertable catheter component.
- This disclosure also provides methods and apparatuses for effectively sterilizing a catheter and the surrounding area while in a body cavity.
- This medical device assembly uses sterilizing EMR to reduce or eliminate the count of infectious agents in, on, or around the catheter while in a body cavity.
- This disclosure also relates to a medical device assembly for insertion of a catheter into a cavity of a patient's body, for delivery to and retrieval of a fluid from the patient's body, comprising an EMR source.
- This source can be from a group of EMR sources including a solid state laser, a semiconductor laser, a diode laser, and a light emitting diode.
- This EMR source provides non-ultraviolet, sterilizing EMR having a wavelength in the range of approximately 380 nm to approximately 900 nm and has an intensity sufficient to inactivate one or more infectious agents.
- This disclosure describes a catheter having an elongate catheter body with at least one internal lumen, a coupling end and a distal end tip, the distal end tip being insertable into the cavity of the patient's body.
- the catheter body is meant to direct both the fluid and the sterilizing EMR axially through the catheter body for delivery into the patient's body at the distal end tip.
- This disclosure includes an optical element disposed within the catheter body and conducive to the axial propagation of the sterilizing EMR through the catheter body.
- this disclosure describes at least one coupling element to connect the radiation source to the catheter body.
- the sterilizing EMR is transmitted down a specialized path within the catheter via an optical element conducive to the axial propagation of the light.
- Various methods could be used to facilitate propagation of the light down the catheter, including a reflective coating within a line of the catheter, a fiber optic cable, a lens, a waveguide, or the like.
- the light source can be a light-emitting diode (LED), laser, fiber optic filament, or the like.
- the medical device assembly and method for disinfection could be utilized in an adjustable duty cycle. If treatments began immediately after insertion of the device, catheter biofilm growth may be inhibited.
- This disclosure also relates to a method for constructing a medical device assembly for insertion into a cavity of a patient's body and for delivery of a fluid to the patient's body comprising the steps of: providing a catheter having an elongate catheter body with at least one internal lumen, a coupling end and an distal end tip, the distal end tip being insertable into the cavity of the patient's body; applying an optical element within the catheter body, the optical element being conducive to the axial propagation of a sterilizing EMR through the catheter body; and coupling an EMR source to the catheter body, the EMR source for providing non-ultraviolet, sterilizing EMR having an intensity sufficient to inactivate one or more infectious agent.
- the device uses a catheter that is inserted into a cavity of a patient's body, wherein said catheter allows both fluid and sterilizing EMR to travel axially through the catheter body.
- the catheter also contains at least one coupling lumen to connect an EMR sterilization source that will transmit the EMR through the coupling lumen and down through the catheter line.
- a coupling element in this context will usually refer to a typical hub on the sterilizing EMR source.
- a catheter with multiple lumens for fluid injection or retrieval contains a separate lumen for transmission of the sterilizing EMR.
- Each lumen has a separate proximal catheter hub assembly.
- These internal lumens converge at a convergence chamber, where individual internal lumens consolidate into a single elongated catheter body while retaining their individual internal paths.
- This device may include use of an optical method for diverting the radiation between the convergence chamber and axially through the designated catheter internal lumen.
- Samples from the distal end tip are often used to characterize the type of infection.
- One embodiment of the disclosure focuses on maintaining full internal reflection of the light down the catheter and delivering the light to the distal end tip of the catheter to reduce or eliminate the count of infectious agents residing thereon.
- the medical device assembly aforementioned would be used in a urological setting.
- the catheter would be placed into the urethra and bladder of the urinary tract.
- the medical device assembly aforementioned would be used in a gastrointestinal setting.
- the medical device assembly aforementioned would be used in an intravascular setting.
- the medical device assembly aforementioned would be used within the cranial cavity of a patient.
- the medical device assembly aforementioned would be used within the spinal cavity of a patient.
- the medical device assembly aforementioned would be used within an ophthalmic cavity of a patient.
- FIG. 1 is a perspective view of a double lumen catheter and an EMR component
- FIG. 2 is a schematic view of a tunneled triple lumen catheter embodiment as inserted into a body cavity;
- FIG. 3 is a perspective view of an alternative embodiment showing a urinary catheter
- FIG. 4 is a cross sectional view of an exemplary embodiment of a single lumen with a reflective surface to allow reflective axial propagation of EMR;
- FIG. 5 a is a cross sectional view of an alternate embodiment showing a double lumen line with a reflective surface to allow reflective axial propagation of EMR;
- FIG. 5 b is a cross sectional view of an alternate embodiment showing a triple lumen line with a reflective surface to allow reflective axial propagation of EMR;
- FIG. 6 a is an exploded perspective view of the catheter hub and coupling element assembly
- FIG. 6 b is a cross sectional view of the catheter hub and laser port assembly of FIG. 6 a;
- FIG. 7 a is a cross sectional view of an exemplary embodiment showing inbound lines into a convergence chamber
- FIG. 7 b is a perspective view of an exemplary embodiment showing inbound lines into a convergence chamber
- FIG. 8 is a convergence chamber perspective view showing internal configuration in phantom lines.
- FIG. 9 is a perspective view of a distal end tip with internal configuration and phantom lines.
- the phrases “connected to,” “coupled to” and “in communication with” refer to any form of interaction between two or more entities, including mechanical, electrical, magnetic, electromagnetic, fluid, and thermal interaction. Two components may be coupled to each other even though they are not in direct contact with each other.
- the term “abutting” refers to items that are in direct physical contact with each other, although the items may not necessarily be attached together.
- the phrase “fluid communication” refers to two features that are connected such that a fluid within one feature is able to pass into the other feature.
- a medical device assembly comprises a non-ultraviolet, electromagnetic radiation (EMR) component 20 , and an insertable catheter component 22 .
- the non-ultraviolet, EMR component 20 broadly comprises an elongate body 24 used to enclose the EMR power source 26 and a coupling element 28 to couple the two components of the assembly.
- the EMR shall be defined as electromagnetic radiation (EMR) manifested as light emitted in a range from 380 nm to 900 nm having a high intensity sufficient to inactivate one or more infectious agents.
- EMR source has an adjustable duty cycle length so that the EMR can be provided at the most effective times and for beneficial time periods.
- wavelengths in a range from 380 nm to 900 nm with a sufficient intensity will inactivate one or more infectious agents
- more precise wavelengths may have more particular efficacy against certain infectious agents or for a desired purpose. It has been determined that sterilizing EMR of wavelengths including wavelengths centered about 400 nm, 405 nm, 415 nm, 430 nm, 440 nm, 455 m, 470 nm, 475 nm, 660 nm, and 808 nm have particular efficacy.
- the insertable catheter component 22 being capable of at least partially being inserted into a cavity of the patient's body to deliver the non-ultraviolet EMR, comprises of at least one internal lumen 30 , a proximal catheter hub assembly 32 , and a distal end tip 34 .
- An internal lumen 30 being simply defined as the internal path by which fluid or EMR may travel. In cases of a single or multi-lumen catheter, similar features in the drawings will be labeled with the same number.
- the distal end tip 34 being insertable into the cavity of the patient's body at a determined site A, wherein the elongate catheter body 36 directs both the fluid and the sterilizing EMR axially through the elongate catheter body 36 for delivery into the patient's body at the distal end tip 34 .
- the elongate catheter body is described as being an elongated catheter having at least one internal lumen.
- Sterilizing EMR will travel axially through the catheter which may be of varying lengths 38 depending on its specific need.
- the fluid used through the internal lumen 30 is generally configured to contain pharmacological compounds (e.g., a drug) or biological fluids (e.g., blood, urine, or cerebral spinal fluid).
- the embodiment shown contains two lumens 30 , and proximal catheter hub assemblies 32 . Each may be used to direct fluid or the sterilizing EMR axially through the elongate catheter body 36 depending on the specific needs of the catheter. In multi-lumen embodiments a dedicated single lumen may also be designated for the axial propagation of EMR and each additional lumen dedicated for the propagation of fluid axially. In this way both fluid and EMR can be axially propagated simultaneously through their individual lines.
- Each multi-lumen embodiment may contain a convergence chamber 40 , at the point where individual internal lumens 30 converge into a single elongated catheter body 36 while retaining their individual internal paths.
- the optical element 50 (shown best in FIG. 4 ) discontinues at the termination point 42 so that the sterilizing EMR can irradiate throughout the tip and surrounding cavity area.
- This embodiment also is fitted with flexible protection tubing 44 to protect the lumen at the proximal catheter hub assembly 32 and between the proximal catheter hub assembly 32 and convergence chamber 40 . If manual line occlusion is necessary it may be performed with the line clamp 46 .
- a schematic view of another embodiment of the medical device assembly comprises a non-ultraviolet, EMR component 20 , and an insertable catheter component 22 .
- the embodiment shown is specifically a tunneled triple lumen central line variation of the disclosure; however it should be understood that the catheter may encompass any type of accessing catheter (e.g., vascular, gastrointestinal, etc.) without departing from the scope and spirit of the invention.
- the non-ultraviolet EMR component 20 is coupled to the proximal catheter hub assembly 32 of the insertable catheter component 22 .
- the other coupling hubs 32 are available for axial propagation of fluid.
- Each designated internal lumen 30 propagates the EMR or fluid between its proximal catheter hub assembly 32 and distal end tip 34 .
- the transcutaneous portion A of the insertable catheter body 36 is often a high source of infections.
- a dedicated area 48 is a region free from the optical element 50 within the elongate catheter body 36 . This allows the sterilizing EMR to irradiate outward and inactivate the infectious agents at the insertion site A.
- the optical element 50 discontinues at the termination point 42 so that the sterilizing EMR can irradiate throughout the tip and surrounding cavity area.
- a perspective view of yet another exemplary embodiment of the medical device assembly comprises a non-ultraviolet, EMR component 20 , and an insertable catheter component 22 .
- the exemplary embodiment shown is specifically an indwelling urinary balloon catheter variation; however, it should be understood that catheter may also encompass any type of drainage catheter (e.g., urinary, fecal, cranial, or spinal).
- the EMR component 20 is connected at the coupling element 28 to the proximal catheter hub assembly 32 of the insertable catheter component 22 . Fluid delivery from the proximal catheter hub assembly 32 to the distal end tip 34 may also be made through the proximal catheter hub assembly 32 . Sterilizing EMR will travel axially through the indwelling catheter, which may be of varying lengths 38 depending on its specific need.
- the transcutaneous portion A of the insertable catheter body 36 is often a high source of infections.
- a dedicated area 48 is a region free from the optical element 50 within the elongate catheter body 36 , thereby allowing the sterilizing EMR to irradiate outward and inactivate the infectious agents at the insertion site A.
- This exemplary embodiment of the disclosure is shown having an inflatable balloon 52 to assist in securing the elongate catheter body 36 in the desired location within the patient's body. Once the elongate catheter body 36 is disposed within the patient's body, the inflatable balloon 52 may be inflated through the addition of fluid through the proximal catheter hub assembly 32 .
- the elongate catheter body 36 is free of the optical element 50 .
- the termination point of the optical element 42 allows the sterilizing EMR to irradiate throughout the distal end tip 34 and surrounding cavity area.
- Drainage occurs from the distal end tip fluid exposure site 54 through the elongate catheter body 36 and out of the drainage hub 56 .
- the drainage hub 56 can be connected to a variety of containers for storage or disposal of the draining fluid based on the needs of the embodiment.
- FIG. 4 of the present disclosure a cross-sectional view of an exemplary embodiment of a single lumen elongate catheter body 36 is shown.
- the sterilizing EMR and fluid element 58 EF travels axially.
- the numbering is such that the letter “E” is representative of the transmission of EMR and the letter “F” is representative of the transmission of fluid. This numbering convention will be continued hereafter.
- the layers comprise an outer layer 60 which would come into contact with a patient's cavity walls, an optical element layer 50 to assist in the axial propagation of EMR through the elongate catheter body 36 , and a translucent layer 62 which comes into contact with the EMR and the fluid.
- the elongate catheter body 36 of the present exemplary embodiment has a single internal lumen 30 and is a desirable option in areas where multiple lumens are not possible, e.g., narrow cavities, in children.
- the optical element 50 can be manufactured using a broad range of reflective technologies.
- the most common known would include, individually or in combination, at least one of a metallic coating, reflective coating, reflective plating, vapor deposited layer, co-extruded metallic particle layer, a co-extruded reflective layer, reflective film, and embedded metallic resin.
- the optical element 50 may be removed. In the present disclosure these areas include: inside the convergence chamber 40 , at the insertion site A, and at the distal end tip 34 . In embodiments in which the optical element 50 may come in contact with the patient's body cavity, the outer layer 60 may be removed.
- FIG. 5 a of the present disclosure a cross-sectional view of another exemplary embodiment of a double lumen elongate catheter body 36 is shown.
- the fluid element 58 F travels axially.
- the sterilizing EMR element 58 E may also travel axially.
- the sterilizing EMR element 58 E and the fluid element 58 F retain their own individual lumens to travel through.
- the optical element 50 may also be embedded in the catheter body 36 so that it surrounds the fluid element 58 F.
- the layers comprise an outer layer 60 which would come into contact with a patient's cavity walls, an optical element layer 50 to assist in the substantial axial propagation of EMR through the elongate catheter body 36 , and a translucent layer 62 which may contact the EMR and the fluid.
- substantially axial propagation of EMR means that EMR advances along a generally axial path proximate the longitudinal axis of the catheter, though the path need not be linear or sinusoidal.
- the elongate catheter body 36 is a desirable option in areas where drainage of fluid may be necessary (e.g., urinary catheters, cranial catheters, spinal catheters, fecal catheters, and the like).
- the optical element 50 can be manufactured using a broad range of reflective technologies. The most common would include: a metallic coating, reflective coating, reflective plating, vapor deposited layer, co-extruded metallic particle or reflective layer, reflective film and embedded metallic resin. It is desirable for the catheter to be both sterilize-able and feasible to use in a living patient. All additional methods for assisting in the substantial propagation of EMR using a reflective surface for the effective transmission of sterilizing EMR are also contemplated. In areas of the elongate catheter body 36 that are desirable to have the sterilizing EMR irradiate the surrounding tissue and not propagate the length of the catheter axially, the optical element 50 may be removed. In the present disclosure, these areas may include: inside the convergence chamber 40 , at the insertion site A, and at distal end tip 34 . In certain embodiments which the optical element 50 may come in contact with the patient's body cavity, the outer layer 60 may be removed.
- FIG. 5 b shows a cross-sectional view of the exemplary embodiment of a multi-lumen elongate catheter body 36 .
- the fluid element 58 F or multiple fluid elements 58 F may travel axially.
- the sterilizing EMR element 58 E may also travel axially.
- the sterilizing EMR element 58 E and the fluid element 58 F retain their own individual lumens to travel through.
- the optical element 50 may also be embedded in the catheter body 36 so that it surrounds the fluid element 58 F.
- the layers comprise an outer layer 60 which would come into contact with a patient's cavity walls, an optical element layer 50 to assist in the substantial axial propagation of EMR through the elongate catheter body 36 , and a translucent layer 62 which comes into contact with the EMR.
- the outer layer 60 may be removed.
- the elongate catheter body 36 of FIG. 5 b is a triple lumen embodiment and may be a desirable option in areas where multiple fluid delivery or extraction is necessary simultaneously. In hemodialysis, venous and arterial blood is exchanged simultaneously. This exemplary embodiment would allow for the necessary function of the catheter to continue as desired.
- FIG. 6 a of the present disclosure is an exploded view of the EMR component 20 and the proximal catheter hub assembly 32 .
- the EMR component 20 comprises an elongate body 24 used to enclose the EMR power source 26 as well as a coupling element 28 to couple the two components of the assembly.
- the coupling element 28 shown comprises two parts, an inner male component 64 and an outer threaded male component 66 .
- the inner male component 64 is designed to both align with and recess into the catheter hub assembly 32 , thereby giving an aligned union between the coupling element 28 and the catheter hub assembly 32 , as well as ensuring a minimal amount of EMR is lost by escaping the catheter hub assembly 32 .
- the outer threaded component 66 has a threaded region which can be used to fasten itself to the catheter hub female coupling 68 by rotating onto it. It should be understood that for some embodiments, it may be advantageous to implement a focusing lens to focus the EMR for more effective axial propagation. A person of skill in the art, armed with this disclosure, could effectively implement a focusing lens.
- the proximal catheter hub assembly 32 comprises a catheter hub female coupling 68 and an elongated hub body 70 .
- the internal wall of the elongated hub body 70 also may be coated with an optical element 50 .
- the EMR source comprises an elongate body 24 used to enclose the EMR power source 26 and a coupling element 28 to couple the two components of the assembly.
- the coupling element 28 shown comprises two parts, an inner male component 64 and an outer threaded male component 66 .
- the inner male component 64 is designed to both align with and recess into the proximal catheter hub assembly 32 , thereby giving an aligned union between the coupling element 28 and the proximal catheter hub assembly 32 as well as ensuring a minimal amount of EMR is lost by escaping from the proximal catheter hub assembly 32 .
- the outer threaded male component 66 has a threaded region, which can be used to fasten itself to the catheter hub female coupling 68 by rotating onto it.
- the proximal catheter hub assembly 32 comprises a catheter hub female coupling 68 and an elongated hub body 70 .
- the internal wall of the elongated hub body 70 also may be coated with an optical element 50 .
- a cross-sectional view of a triple internal lumen 30 embodiment shows fluid elements 58 F and an EMR element 58 E joining into the convergence chamber 40 and leaving as a single elongate catheter body 36 while retaining individual paths.
- the convergence chamber 40 contains an adjustable optical diversion element assembly 74 which will redirect EMR from the electromagnetic power source 26 into at least one of the internal lumens 30 containing a fluid element 58 F. If desired, sterilizing the fluid, which may travel through the fluid element 58 F, may be accomplished by reflecting at least a portion of the EMR back up the individual feed lines.
- the optical element 50 may also be embedded in the catheter body 36 so that it surrounds the fluid element 58 F. In this way, the optical element 50 is able to sterilize the length of the fluid line axially from the proximal catheter hub assembly 32 to the distal end tip 34 .
- the convergence chamber 40 contains attachment arms on either side 76 to assist in securing to the patient. If suturing or additional support is necessary there are specialized holes 78 in the attachment arms, which allow a point to fasten to.
- the transcutaneous portion A of the insertable catheter body 36 is often a high source of infections.
- a dedicated transcutaneous area 48 is a region free from the optical element 50 within the catheter body 36 , thereby allowing the sterilizing EMR to irradiate outward and inactivate the infectious agents at the insertion site A.
- a profile view of a triple internal lumen 30 embodiment shows fluid element 58 F and an EMR element 58 E joining into the convergence chamber 40 and leaving as a single elongate catheter body 36 while retaining individual paths.
- the convergence chamber 40 may contain an adjustable optical diversion element assembly 74 which will redirect EMR from the electromagnetic power source 26 into at least one of the internal lumens 30 containing a fluid element 58 F, thereby sterilizing the fluid which may travel through the fluid element 58 F.
- the convergence chamber 40 has attachment arms on either side 76 to assist in securing itself to the patient. If suturing or additional support is necessary there are specialized holes 78 in the attachment arms, which allow a point to fasten to.
- FIG. 8 a perspective view is provided of a triple lumen embodiment with internal phantom lines showing fluid lines 58 F and an EMR line 58 E joining into the convergence chamber 40 and leaving as a single elongate catheter body 36 while retaining individual paths.
- the convergence chamber 40 may contain an adjustable optical diversion element assembly 74 which will redirect EMR from the electromagnetic power source 26 into at least one of the internal lumens 30 containing a fluid element 58 F.
- the optical element 50 may also be embedded in the catheter body 36 so that it surrounds the fluid element 58 F. In this way, the optical element 50 is able to sterilize the length of the fluid line axially both to the proximal catheter hub assembly 32 and to the distal end tip 34 .
- the adjustable optical diversion element assembly 74 comprises an external switch 80 accessible from outside the convergence chamber 40 , an optical actuator 82 and an optical dispersion element 84 . When the external switch 80 is activated, it will engage the actuator 82 and align the optical dispersion element 84 to re-direct the EMR. This process of optical diversion may be either mechanical or electrical in nature.
- the distal end tip 34 comprises an elongate catheter body 36 , at least one internal lumen 30 capable of substantial axial transmission of an EMR element 58 E and fluid element 58 F or combination thereof, an optical element termination point 42 , a distal end tip fluid exposure site 54 , a fixed optical dispersion element 86 .
- EMR and fluid travel axially through the elongate catheter body 36 .
- the fluid is able to exit or enter at the distal end tip fluid exposure site 54 depending on its needs.
- the EMR will become dispersed by the fixed optical dispersion element 86 and irradiate throughout the distal end tip 34 and surrounding cavity area.
- Any methods disclosed herein may comprise one or more steps or actions for performing the described method.
- the method steps and/or actions may be interchanged with one another.
- the order and/or use of specific steps and/or actions may be modified.
Abstract
Description
Claims (20)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/801,750 US9808647B2 (en) | 2012-04-05 | 2013-03-13 | Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity |
US15/668,266 US10307612B2 (en) | 2012-04-05 | 2017-08-03 | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US15/791,574 US10729916B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus for coupling an electromagnetic radiation conduction system into a catheter |
US15/791,617 US10238890B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US16/144,009 US10894173B2 (en) | 2012-04-05 | 2018-09-27 | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US16/276,459 US10471277B2 (en) | 2012-04-05 | 2019-02-14 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US16/364,051 US11229808B2 (en) | 2012-04-05 | 2019-03-25 | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation versatilely via a catheter residing in a body cavity |
US16/680,208 US11529530B2 (en) | 2012-04-05 | 2019-11-11 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US17/579,657 US11497932B2 (en) | 2012-04-05 | 2022-01-20 | Electromagnetic radiation delivery and monitoring system and methods for preventing, reducing and/or eliminating catheter-related infections during institutional or in-home use |
US17/947,868 US20230075669A1 (en) | 2012-04-05 | 2022-09-19 | Light delivery system with a fiber optic disposable for preventing, reducing and/or eliminating infections during institutional or in-home use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261686432P | 2012-04-05 | 2012-04-05 | |
US13/801,750 US9808647B2 (en) | 2012-04-05 | 2013-03-13 | Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/424,732 Continuation-In-Part US10543338B2 (en) | 2012-04-05 | 2017-02-03 | Method and apparatus for removable catheter visual light therapeutic system |
US17/000,736 Continuation-In-Part US11229728B1 (en) | 2012-04-05 | 2020-08-24 | Method and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation in a dialysis system |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/424,732 Continuation-In-Part US10543338B2 (en) | 2012-04-05 | 2017-02-03 | Method and apparatus for removable catheter visual light therapeutic system |
US15/668,266 Continuation-In-Part US10307612B2 (en) | 2012-04-05 | 2017-08-03 | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US15/791,574 Continuation US10729916B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus for coupling an electromagnetic radiation conduction system into a catheter |
US15/791,617 Continuation US10238890B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
Publications (2)
Publication Number | Publication Date |
---|---|
US20130267888A1 US20130267888A1 (en) | 2013-10-10 |
US9808647B2 true US9808647B2 (en) | 2017-11-07 |
Family
ID=49292878
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/801,750 Active 2036-05-20 US9808647B2 (en) | 2012-04-05 | 2013-03-13 | Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity |
US15/791,617 Active 2033-03-20 US10238890B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US15/791,574 Active 2033-08-16 US10729916B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus for coupling an electromagnetic radiation conduction system into a catheter |
US16/276,459 Active US10471277B2 (en) | 2012-04-05 | 2019-02-14 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US16/680,208 Active 2034-05-11 US11529530B2 (en) | 2012-04-05 | 2019-11-11 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/791,617 Active 2033-03-20 US10238890B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US15/791,574 Active 2033-08-16 US10729916B2 (en) | 2012-04-05 | 2017-10-24 | Methods and apparatus for coupling an electromagnetic radiation conduction system into a catheter |
US16/276,459 Active US10471277B2 (en) | 2012-04-05 | 2019-02-14 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US16/680,208 Active 2034-05-11 US11529530B2 (en) | 2012-04-05 | 2019-11-11 | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
Country Status (1)
Country | Link |
---|---|
US (5) | US9808647B2 (en) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160038621A1 (en) * | 2013-03-14 | 2016-02-11 | Teleflex Medical Incorporated | Optical fiber based antimicrobial ultraviolet radiation therapy system |
US20180043180A1 (en) * | 2012-04-05 | 2018-02-15 | Nathaniel L. Rhodes | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US20190350663A1 (en) * | 2018-05-18 | 2019-11-21 | Bard Access Systems, Inc. | Connection Systems And Methods Thereof For Establishing An Electrical Connection Through A Drape |
US10543058B2 (en) | 2015-08-21 | 2020-01-28 | Corning Incorporated | Medical device disinfecting system and method |
US10549114B2 (en) | 2016-02-03 | 2020-02-04 | Corning Incorporated | Therapeutic illumination assemblies and methods of illuminating medical devices and biological material using the same |
US10582843B2 (en) | 2015-03-24 | 2020-03-10 | Corning Incorporated | Illuminating surgical device having light diffusing fiber |
US10639389B2 (en) | 2018-04-30 | 2020-05-05 | CathBuddy, Inc | Methods and devices for portable sterilization and containment of medical devices |
US10786585B2 (en) | 2013-11-26 | 2020-09-29 | Corning Incorporated | Anti-bacterial light delivery system and method for disinfecting a surface |
US10918770B2 (en) | 2016-02-12 | 2021-02-16 | Corning Incorporated | Vacuum assisted wound closure assembly and methods of irradiating a wound using the same |
US10992078B2 (en) | 2018-01-29 | 2021-04-27 | Bard Access Systems, Inc. | Connection system for establishing an electrical connection through a drape and methods thereof |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11159730B2 (en) * | 2016-09-02 | 2021-10-26 | Trumpf Maschinen Austria Gmbh & Co. Kg. | Bending machine comprising a work area image detecting device and method for representing a work area |
US11213695B2 (en) | 2013-11-26 | 2022-01-04 | Corning Incorporated | Illuminated bandage and method for disinfecting a wound |
US11229728B1 (en) * | 2020-08-24 | 2022-01-25 | Light Line Medical, Inc. | Method and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation in a dialysis system |
US11241585B2 (en) * | 2016-02-05 | 2022-02-08 | Light Line Medical, Inc. | Method and apparatus for removable catheter visual light therapeutic system |
US11327213B2 (en) | 2017-10-24 | 2022-05-10 | Corning Incorporated | Light diffusing optical fibers having uniform illumination along diffusion lengths and methods of forming the same |
US11491345B2 (en) * | 2013-02-07 | 2022-11-08 | Rocomp Global, Llc | Electromagnetic radiation targeting devices, assemblies, systems and methods |
US11524173B2 (en) | 2015-07-28 | 2022-12-13 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
USRE49416E1 (en) | 2009-11-20 | 2023-02-14 | Corning Incorporated | Optical fiber illumination systems and methods |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
US11726273B2 (en) | 2018-12-21 | 2023-08-15 | Corning Incorporated | Light diffusing multi-fiber design configured for use with UV LEDs |
US11724124B2 (en) | 2015-11-06 | 2023-08-15 | Illuminoss Medical, Inc. | Systems and methods for anti-microbial effect for bones |
US11737848B2 (en) | 2019-07-29 | 2023-08-29 | Bard Access Systems, Inc. | Connection systems and methods for establishing optical and electrical connections through a drape |
US11786620B2 (en) | 2018-04-30 | 2023-10-17 | CathBuddy, Inc. | Handheld cleaner-disinfector for medical devices |
US11813368B2 (en) | 2021-08-27 | 2023-11-14 | Abl Medical Inc. | Anti-microbial blue light systems and methods |
US11850314B2 (en) | 2018-01-16 | 2023-12-26 | Corning Incorporated | Illumination of light diffusing optical fibers, illumination of blue-violet light delivery systems, blue-violet light delivery systems, and methods for blue-violet light induced disinfection |
US11904130B2 (en) | 2021-03-23 | 2024-02-20 | University Of Washington | Fluid access devices and methods |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10894173B2 (en) | 2012-04-05 | 2021-01-19 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US11229808B2 (en) * | 2012-04-05 | 2022-01-25 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation versatilely via a catheter residing in a body cavity |
US11497932B2 (en) | 2012-04-05 | 2022-11-15 | Light Line Medical, Inc. | Electromagnetic radiation delivery and monitoring system and methods for preventing, reducing and/or eliminating catheter-related infections during institutional or in-home use |
US10307612B2 (en) | 2012-04-05 | 2019-06-04 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US10543338B2 (en) * | 2016-02-05 | 2020-01-28 | Light Line Medical, Inc. | Method and apparatus for removable catheter visual light therapeutic system |
WO2016133747A1 (en) | 2015-02-20 | 2016-08-25 | Portela Soni Medical Llc | Improved urinary catheter, kit and method |
KR101846071B1 (en) * | 2015-06-05 | 2018-04-05 | 이제범 | catheter apparatus for cranial cavity |
US10207080B2 (en) * | 2015-04-20 | 2019-02-19 | Je Bum Lee | Catheter apparatus for cranial cavity |
US10870015B2 (en) * | 2015-04-30 | 2020-12-22 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic non-ultraviolet electromagnetic radiation for an endotracheal tube |
US10793449B2 (en) | 2016-04-27 | 2020-10-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Fiber-optic integrated membrane reactor |
US9925285B1 (en) | 2017-06-21 | 2018-03-27 | Inikoa Medical, Inc. | Disinfecting methods and apparatus |
US11071853B2 (en) * | 2017-06-21 | 2021-07-27 | Uv Light Care, Inc. | System and method for sterilization using ultraviolet radiation |
CN111315434B (en) * | 2017-08-03 | 2022-05-24 | 光线医疗股份有限公司 | Method and apparatus for delivering therapeutic non-ultraviolet electromagnetic radiation to inactivate infectious agents |
US10765767B2 (en) | 2018-06-19 | 2020-09-08 | Inikoa Medical, Inc. | Disinfecting methods and apparatus |
WO2020072339A1 (en) * | 2018-10-01 | 2020-04-09 | Westerhoff Paul K | Uv-c wavelength radially emitting particle-enabled optical fibers for microbial disinfection |
US11754778B2 (en) | 2018-11-21 | 2023-09-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Photoresponsive polymer coated optical fibers for water treatment |
CN113597320A (en) * | 2019-03-25 | 2021-11-02 | 光线医疗股份有限公司 | Method and apparatus for multipurpose delivery of therapeutic non-ultraviolet electromagnetic radiation via a catheter residing in a body lumen |
AU2020291419A1 (en) * | 2019-06-13 | 2021-12-16 | Hollister Incorporated | Reusable urinary catheter kits |
JPWO2021024992A1 (en) * | 2019-08-05 | 2021-02-11 | ||
EP4093469A1 (en) * | 2020-01-20 | 2022-11-30 | Light Line Medical, Inc. | Methods and apparatus for removable catheter visual light therapeutic system |
GB202004616D0 (en) | 2020-03-30 | 2020-05-13 | Clean Blue Ltd | Self-sterilising urinary catheter |
Citations (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4412834A (en) | 1981-06-05 | 1983-11-01 | Baxter Travenol Laboratories | Antimicrobial ultraviolet irradiation of connector for continuous ambulatory peritoneal dialysis |
US4512762A (en) | 1982-11-23 | 1985-04-23 | The Beth Israel Hospital Association | Method of treatment of atherosclerosis and a balloon catheter for same |
US5102410A (en) * | 1990-02-26 | 1992-04-07 | Dressel Thomas D | Soft tissue cutting aspiration device and method |
US5222949A (en) * | 1991-07-23 | 1993-06-29 | Intermed, Inc. | Flexible, noncollapsible catheter tube with hard and soft regions |
US5260020A (en) * | 1992-09-17 | 1993-11-09 | Wilk Peter J | Method and apparatus for catheter sterilization |
US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
US5607419A (en) | 1995-04-24 | 1997-03-04 | Angiomedics Ii Inc. | Method and apparatus for treating vessel wall with UV radiation following angioplasty |
US5637877A (en) | 1995-06-06 | 1997-06-10 | Rare Earth Medical, Inc. | Ultraviolet sterilization of instrument lumens |
US5702432A (en) | 1996-10-03 | 1997-12-30 | Light Sciences Limited Partnership | Intracorporeal light treatment of blood |
US5855203A (en) * | 1997-12-19 | 1999-01-05 | Matter; Jean-Paul | Respiratory circuit with in vivo sterilization |
US6119037A (en) | 1995-06-06 | 2000-09-12 | Board Of Regents, The University Of Texas System | Electrode system in iontophoretic treatment devices |
US20020087206A1 (en) * | 2000-12-28 | 2002-07-04 | Henry Hirschberg | Implantable intracranial photo applicator for long term fractionated photodynamic and radiation therapy in the brain and method of using the same |
US6461569B1 (en) * | 2000-11-15 | 2002-10-08 | Ethicon Endo Surgery, Inc. | Method and apparatus for ultraviolet radiation catheter sterilization system |
US20030017073A1 (en) * | 2001-06-15 | 2003-01-23 | Uv-Solutions, Llc | Method and apparatus for sterilizing or disinfecting catheter components |
US6551346B2 (en) | 2000-05-17 | 2003-04-22 | Kent Crossley | Method and apparatus to prevent infections |
US6562295B1 (en) | 1999-06-30 | 2003-05-13 | Ceramoptec Industries, Inc. | Bacteria resistant medical devices |
US20040193218A1 (en) * | 2002-12-02 | 2004-09-30 | Glenn Butler | Wound management systems and methods for using the same |
US20050090722A1 (en) | 2003-09-17 | 2005-04-28 | Thomas Perez | Method and apparatus for providing UV light to blood |
US20050128742A1 (en) * | 2003-03-14 | 2005-06-16 | Chen James C. | Light generating device that self centers within a lumen to render photodynamic therapy |
US7232429B2 (en) | 2002-04-08 | 2007-06-19 | Boston Scientific Corporation | Medical devices |
US20070219605A1 (en) | 2006-03-20 | 2007-09-20 | Palomar Medical Technologies, Inc. | Treatment of tissue volume with radiant energy |
US20080161748A1 (en) | 2002-04-02 | 2008-07-03 | Marc Joshua Tolkoff | Apparatus and Methods Using Visible Light for Debilitating and/or Killing Microorganisms Within the Body |
US20080159908A1 (en) | 2006-09-09 | 2008-07-03 | Redmond Russell J | Method and apparatus for sterilizing indwelling catheters |
US7449026B2 (en) | 2003-11-14 | 2008-11-11 | Lumerx, Inc. | Intra-cavity catheters and methods of use |
US20080306454A1 (en) | 2007-06-06 | 2008-12-11 | Sikora Christopher F | Apparatus And Method For Sterilization Of An Intravenous Catheter |
US20090216300A1 (en) * | 2006-01-18 | 2009-08-27 | Light Sciences Oncology, Inc. | Method and apparatus for light-activated drug therapy |
US20090257910A1 (en) | 2008-04-10 | 2009-10-15 | Segal Jeremy P | Intravenous catheter connection point disinfection |
US20100072399A1 (en) | 2008-09-23 | 2010-03-25 | Ondine International Holdings Ltd. | Portable Photodynamic Disinfection Light Delivery Device for Catheter |
US7730894B2 (en) | 2003-03-14 | 2010-06-08 | Light Sciences Oncology, Inc. | Photodynamic therapy apparatus and method for vascular tissue treatment |
US20100246169A1 (en) | 2007-10-31 | 2010-09-30 | John Anderson | Lighting Device |
US20100256607A1 (en) | 2007-08-15 | 2010-10-07 | Daniel Rogers Burnett | Method and apparatus for automated active sterilization of fully implanted devices |
US20110085936A1 (en) | 2009-03-31 | 2011-04-14 | Eyal Haytman | Methods and Apparatus for Reducing Count of Infectious Agents in Intravenous Access Systems |
US8057464B2 (en) | 2006-05-03 | 2011-11-15 | Light Sciences Oncology, Inc. | Light transmission system for photoreactive therapy |
US20110306956A1 (en) * | 2010-01-07 | 2011-12-15 | Cheetah Omni, Llc | Laser-based method and system for selectively processing target tissue material in a patient and optical catheter assembly for use therein |
US8276590B2 (en) * | 2005-05-18 | 2012-10-02 | Cooltouch Incorporated | Thermally mediated tissue molding |
US20130030249A1 (en) | 2009-02-06 | 2013-01-31 | Endoclear Llc | Visualized endotracheal tube placement systems |
US20130060188A1 (en) * | 2011-06-20 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Photocatalytic disinfection of implanted catheters |
US8480722B2 (en) | 2009-03-20 | 2013-07-09 | Mark Klepper | Tubular device delivering light and radiation into a patient |
US8556950B2 (en) * | 2006-08-24 | 2013-10-15 | Boston Scientific Scimed, Inc. | Sterilizable indwelling catheters |
US20130323119A1 (en) | 2012-06-01 | 2013-12-05 | Carefusion 303, Inc. | System and method for disinfection of medical devices |
US20140058253A1 (en) | 2011-04-29 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Methods and Apparatus for Optoacoustic Guidance and Confirmation of Placement of Indwelling Medical Apparatus |
US20140150782A1 (en) | 2012-12-04 | 2014-06-05 | Endoclear Llc | Closed suction cleaning devices, systems and methods |
US8779386B2 (en) | 2010-03-03 | 2014-07-15 | U-VIVO ApS | Assembly and method for disinfecting lumens of devices |
US20140235942A1 (en) | 2011-09-30 | 2014-08-21 | Percuvision, Llc | Medical device and method for internal healing and antimicrobial purposes |
US8933416B2 (en) | 2009-05-11 | 2015-01-13 | Regents Of The University Of Minnesota | Catheter insertion sterilization |
US9039966B2 (en) | 2005-07-29 | 2015-05-26 | University Of Strathclyde | Inactivation of gram-positive bacteria |
US20150343182A1 (en) | 2014-06-03 | 2015-12-03 | Endoclear Llc | Cleaning devices, systems and methods |
US20160256646A1 (en) | 2013-10-07 | 2016-09-08 | Endoclear Llc | Systems and methods for selectively blocking respiratory air flow |
US9550005B2 (en) * | 2013-10-29 | 2017-01-24 | Ultraviolet Interventions, Inc. | Systems and methods for sterilization using UV light |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6007531A (en) * | 1995-11-21 | 1999-12-28 | Catheter Imaging Systems, Inc. | Steerable catheter having disposable module and sterilizable handle and method of connecting same |
CN1282230A (en) * | 1997-10-21 | 2001-01-31 | 加利福尼亚大学董事会 | Photoacoustic removal for occlusions from blood vessels |
US6554824B2 (en) | 2000-12-15 | 2003-04-29 | Laserscope | Methods for laser treatment of soft tissue |
US7704247B2 (en) * | 2003-02-13 | 2010-04-27 | Barbara Ann Soltz | Dual fiber-optic surgical apparatus |
US8706211B2 (en) * | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having self-cleaning surfaces |
US8366652B2 (en) * | 2007-08-17 | 2013-02-05 | The Invention Science Fund I, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
US20110208274A1 (en) | 2008-03-20 | 2011-08-25 | Nomir Medical Technologies Inc | Low aspect ratio diffusing fiber tip |
EP2349479B1 (en) | 2008-10-29 | 2015-08-26 | Nomir Medical Technologies, Inc | Near-infrared electromagnetic modification of cellular steady-state membrane potentials |
CA2836653C (en) * | 2011-05-27 | 2019-03-05 | Colibri Technologies Inc. | Medical probe with fluid rotary joint |
US10894173B2 (en) * | 2012-04-05 | 2021-01-19 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US9808647B2 (en) * | 2012-04-05 | 2017-11-07 | Veritas Medical, L.L.C. | Methods and apparatus to inactivate infectious agents on a catheter residing in a body cavity |
US10307612B2 (en) * | 2012-04-05 | 2019-06-04 | Light Line Medical, Inc. | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity |
US9295742B2 (en) | 2012-04-16 | 2016-03-29 | Puracath Medical, Inc. | System and method for disinfecting a catheter system |
US9999782B2 (en) | 2012-04-16 | 2018-06-19 | Sensor Electronic Technology, Inc. | Ultraviolet-based sterilization |
US20150057648A1 (en) | 2013-08-20 | 2015-02-26 | Angiodynamics, Inc. | Laser Device and Method of Use |
US9962527B2 (en) * | 2013-10-16 | 2018-05-08 | Ra Medical Systems, Inc. | Methods and devices for treatment of stenosis of arteriovenous fistula shunts |
EP3723608B1 (en) | 2017-12-15 | 2023-10-11 | Gastroklenz Inc. | Sensor monitoring system for in-dwelling catheter based treatments |
-
2013
- 2013-03-13 US US13/801,750 patent/US9808647B2/en active Active
-
2017
- 2017-10-24 US US15/791,617 patent/US10238890B2/en active Active
- 2017-10-24 US US15/791,574 patent/US10729916B2/en active Active
-
2019
- 2019-02-14 US US16/276,459 patent/US10471277B2/en active Active
- 2019-11-11 US US16/680,208 patent/US11529530B2/en active Active
Patent Citations (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4412834A (en) | 1981-06-05 | 1983-11-01 | Baxter Travenol Laboratories | Antimicrobial ultraviolet irradiation of connector for continuous ambulatory peritoneal dialysis |
US4512762A (en) | 1982-11-23 | 1985-04-23 | The Beth Israel Hospital Association | Method of treatment of atherosclerosis and a balloon catheter for same |
US5102410A (en) * | 1990-02-26 | 1992-04-07 | Dressel Thomas D | Soft tissue cutting aspiration device and method |
US5695482A (en) | 1991-07-23 | 1997-12-09 | Intermed, Inc. | UV treated catheter |
US5222949A (en) * | 1991-07-23 | 1993-06-29 | Intermed, Inc. | Flexible, noncollapsible catheter tube with hard and soft regions |
US5260020A (en) * | 1992-09-17 | 1993-11-09 | Wilk Peter J | Method and apparatus for catheter sterilization |
US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
US5607419A (en) | 1995-04-24 | 1997-03-04 | Angiomedics Ii Inc. | Method and apparatus for treating vessel wall with UV radiation following angioplasty |
US5637877A (en) | 1995-06-06 | 1997-06-10 | Rare Earth Medical, Inc. | Ultraviolet sterilization of instrument lumens |
US6119037A (en) | 1995-06-06 | 2000-09-12 | Board Of Regents, The University Of Texas System | Electrode system in iontophoretic treatment devices |
US5702432A (en) | 1996-10-03 | 1997-12-30 | Light Sciences Limited Partnership | Intracorporeal light treatment of blood |
US5855203A (en) * | 1997-12-19 | 1999-01-05 | Matter; Jean-Paul | Respiratory circuit with in vivo sterilization |
US6562295B1 (en) | 1999-06-30 | 2003-05-13 | Ceramoptec Industries, Inc. | Bacteria resistant medical devices |
US6551346B2 (en) | 2000-05-17 | 2003-04-22 | Kent Crossley | Method and apparatus to prevent infections |
US6461569B1 (en) * | 2000-11-15 | 2002-10-08 | Ethicon Endo Surgery, Inc. | Method and apparatus for ultraviolet radiation catheter sterilization system |
US20020087206A1 (en) * | 2000-12-28 | 2002-07-04 | Henry Hirschberg | Implantable intracranial photo applicator for long term fractionated photodynamic and radiation therapy in the brain and method of using the same |
US20030017073A1 (en) * | 2001-06-15 | 2003-01-23 | Uv-Solutions, Llc | Method and apparatus for sterilizing or disinfecting catheter components |
US20080161748A1 (en) | 2002-04-02 | 2008-07-03 | Marc Joshua Tolkoff | Apparatus and Methods Using Visible Light for Debilitating and/or Killing Microorganisms Within the Body |
US7232429B2 (en) | 2002-04-08 | 2007-06-19 | Boston Scientific Corporation | Medical devices |
US20040193218A1 (en) * | 2002-12-02 | 2004-09-30 | Glenn Butler | Wound management systems and methods for using the same |
US20050128742A1 (en) * | 2003-03-14 | 2005-06-16 | Chen James C. | Light generating device that self centers within a lumen to render photodynamic therapy |
US7730894B2 (en) | 2003-03-14 | 2010-06-08 | Light Sciences Oncology, Inc. | Photodynamic therapy apparatus and method for vascular tissue treatment |
US20050090722A1 (en) | 2003-09-17 | 2005-04-28 | Thomas Perez | Method and apparatus for providing UV light to blood |
US20060009821A1 (en) | 2003-09-17 | 2006-01-12 | Thomas Perez | Method and apparatus for providing light to blood |
US7449026B2 (en) | 2003-11-14 | 2008-11-11 | Lumerx, Inc. | Intra-cavity catheters and methods of use |
US8276590B2 (en) * | 2005-05-18 | 2012-10-02 | Cooltouch Incorporated | Thermally mediated tissue molding |
US9039966B2 (en) | 2005-07-29 | 2015-05-26 | University Of Strathclyde | Inactivation of gram-positive bacteria |
US20090216300A1 (en) * | 2006-01-18 | 2009-08-27 | Light Sciences Oncology, Inc. | Method and apparatus for light-activated drug therapy |
US20070219605A1 (en) | 2006-03-20 | 2007-09-20 | Palomar Medical Technologies, Inc. | Treatment of tissue volume with radiant energy |
US8057464B2 (en) | 2006-05-03 | 2011-11-15 | Light Sciences Oncology, Inc. | Light transmission system for photoreactive therapy |
US8556950B2 (en) * | 2006-08-24 | 2013-10-15 | Boston Scientific Scimed, Inc. | Sterilizable indwelling catheters |
US20080159908A1 (en) | 2006-09-09 | 2008-07-03 | Redmond Russell J | Method and apparatus for sterilizing indwelling catheters |
US20080306454A1 (en) | 2007-06-06 | 2008-12-11 | Sikora Christopher F | Apparatus And Method For Sterilization Of An Intravenous Catheter |
US20100256607A1 (en) | 2007-08-15 | 2010-10-07 | Daniel Rogers Burnett | Method and apparatus for automated active sterilization of fully implanted devices |
US20100246169A1 (en) | 2007-10-31 | 2010-09-30 | John Anderson | Lighting Device |
US20090257910A1 (en) | 2008-04-10 | 2009-10-15 | Segal Jeremy P | Intravenous catheter connection point disinfection |
US20100072399A1 (en) | 2008-09-23 | 2010-03-25 | Ondine International Holdings Ltd. | Portable Photodynamic Disinfection Light Delivery Device for Catheter |
US20130030249A1 (en) | 2009-02-06 | 2013-01-31 | Endoclear Llc | Visualized endotracheal tube placement systems |
US8480722B2 (en) | 2009-03-20 | 2013-07-09 | Mark Klepper | Tubular device delivering light and radiation into a patient |
US20110085936A1 (en) | 2009-03-31 | 2011-04-14 | Eyal Haytman | Methods and Apparatus for Reducing Count of Infectious Agents in Intravenous Access Systems |
US8574490B2 (en) | 2009-03-31 | 2013-11-05 | Bactriblue, Ltd. | Methods and apparatus for reducing count of infectious agents in intravenous access systems |
US8933416B2 (en) | 2009-05-11 | 2015-01-13 | Regents Of The University Of Minnesota | Catheter insertion sterilization |
US20110306956A1 (en) * | 2010-01-07 | 2011-12-15 | Cheetah Omni, Llc | Laser-based method and system for selectively processing target tissue material in a patient and optical catheter assembly for use therein |
US8779386B2 (en) | 2010-03-03 | 2014-07-15 | U-VIVO ApS | Assembly and method for disinfecting lumens of devices |
US20140058253A1 (en) | 2011-04-29 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Methods and Apparatus for Optoacoustic Guidance and Confirmation of Placement of Indwelling Medical Apparatus |
US20130060188A1 (en) * | 2011-06-20 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Photocatalytic disinfection of implanted catheters |
US20140235942A1 (en) | 2011-09-30 | 2014-08-21 | Percuvision, Llc | Medical device and method for internal healing and antimicrobial purposes |
US20130323119A1 (en) | 2012-06-01 | 2013-12-05 | Carefusion 303, Inc. | System and method for disinfection of medical devices |
US20140150782A1 (en) | 2012-12-04 | 2014-06-05 | Endoclear Llc | Closed suction cleaning devices, systems and methods |
US20160256646A1 (en) | 2013-10-07 | 2016-09-08 | Endoclear Llc | Systems and methods for selectively blocking respiratory air flow |
US9550005B2 (en) * | 2013-10-29 | 2017-01-24 | Ultraviolet Interventions, Inc. | Systems and methods for sterilization using UV light |
US20150343182A1 (en) | 2014-06-03 | 2015-12-03 | Endoclear Llc | Cleaning devices, systems and methods |
Non-Patent Citations (36)
Title |
---|
Bache et al. Clinical studies of the High-Intensity Narrow-Spectrum light Environmental Decontamination System (HINS-light EDS), for continuous disinfection in the burn unit inpatient and outpatient settings. Bums J. Int. Soc. Burn Inj. 38, 69-76 (2012). |
Crnich et al. Are Antimicrobial-Impregnated Catheters Effective? Don't Throw Out the Baby with the Bathwater. Clin. Infect. Dis. 38, 1287-1292 (2004). |
Crump and Collignon: Intravascular catheter-associated infections. Eur. Journal of Clin. Microbiol. Infect. Dis. Off. Publ. Eur. Soc. Clin. Microbiol. 2000, 1-8, 19, Springer. |
Dai et al. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? Drug Resist. Updat. Rev. Comment. Antimicrob. Anticancer Chemother. 15, 223-236 (2012). |
De Lucca et al. Blue light (470 nm) effectively inhibits bacterial and fungal growth. Lett. Appl. Microbiol. (2012). doi:10.1111/Iam.12002. |
Enwemeka et al. Visible 405 nm SLD light photo-destroys methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Lasers Surg. Med. 40, 734-737 (2008). |
Feuerstein et al. Mechanism of visible light phototoxicity on Porphyromonas gingivalis and Fusobacterium nucleatum. Photochem. Photobiol. 81, 1186-1189 (2005). |
Fuks et al. Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res. 54, 2582-2590 (1994). |
Furuya et al. Central Line Bundle Implementation in US Intensive Care Units and Impact on Bloodstream Infections. Plos One 6, (2011). |
Kaya et al. The use of 808-nm light therapy to treat experimental chronic osteomyelitis induced in rats by methicillin-resistant Staphylococcus aureus. Photomed. Laser Surg. 29, 405-412 (2011). |
Kennedy et al. Disinfection of Male Luer Style Connectors for Prevention of Catheter Related Bloodstream Infections Using an Isopropyl Alcohol Dispensing Cap. J. Med. Devices 4, 027509-027509 (2010). |
Kleinpell et al. Targeting Health Care-Associated Infections: Evidence-Based Strategies, Patient Safety and Quality: An Evidence-Based Handbook for Nurses (Hughes, R. G.) (Agency for Healthcare Research and Quality (US), 2008). |
Lipovsky et al. Sensitivity of Staphylococcus aureus strains to broadband visible light. Photochem. Photobiol. 85, 255-260 (2009). |
Lipovsky et al. Visible Light-Induced Killing of Bacteria as a Function of Wavelength: Implication for Wound Healing. Lasers in Surgery and Medicine 42:467-472 (2010)-. |
Lipovsky et al. Visible Light-Induced Killing of Bacteria as a Function of Wavelength: Implication for Wound Healing. Lasers in Surgery and Medicine 42:467-472 (2010)—. |
Litscher et al. Blue 405 nm laser light mediates heart rate-investigations at the acupoint Neiguan (Pe.6) in Chinese adults. North Am. J. Med. Sci. 1, 226-231 (2009). |
Litscher et al. Blue 405 nm laser light mediates heart rate—investigations at the acupoint Neiguan (Pe.6) in Chinese adults. North Am. J. Med. Sci. 1, 226-231 (2009). |
Litscher. Integrative laser medicine and high-tech acupuncture at the medical university of graz, austria, europe. Evid.-Based Complement. Altern. Med. Ecam 2012, 103109 (2012). |
Maclean et al. High-intensity narrow-spectrum light inactivation and wavelength sensitivity of Staphylococcus aureus. Fems Microbiol. Lett. 285, 227-232 (2008). |
Maclean et al. Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array. Appl. Environ. Microbiol. 75, 1932-1937 (2009). |
Maclean et al: Environmental decontamination of a hospital isolation room using high-intensity narrow-spectrum light. Journal Hosp. Infect., 2010, 247-251, 76, Elsevier. |
McDonald et al. Effect of 405-nm high-intensity narrow-spectrum light on fibroblast-populated collagen lattices: an in vitro model of wound healing. J. Biomed. Opt. 16, 048003 (2011). |
McGirt et al. Risk factors for pediatric ventriculoperitoneal shunt infection and predictors of infectious pathogens. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 36, 858-862 (2003). |
Moharikar et al. Apoptotic-Like Cell Death Pathway Is Induced in Unicellular Chlorophyte Chlamydomonas Reinhardtii (chlorophyceae) Cells Following Uv Irradiation: Detection and Functional Analyses1. J. Phycol. 42, 423-433 (2006). |
Mrozek et al. Bloodstream infection after positive catheter cultures: what are the risks in the intensive care unit when catheters are routinely cultured on removal? Crit. Care Med. 39, 1301-1305 (2011). |
Murdoch et al. Bactericidal Effects of 405 nm Light Exposure Demonstrated by Inactivation of Escherichia, Salmonella, Shigella, Listeria, and Mycobacterium Species in Liquid Suspensions and on Exposed Surfaces. Sci. World J. 2012, (2012). |
O'Grady et al. Guidelines for the prevention of intravascular catheter-related infections. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 52, e162-193 (2011). |
Oncu and Sakarya: Central Venous Catheter-Related Infections: An Overview with Special Emphasis on Diagnosis. Prevention and Management. The Internet Journal of Anesthesiology. 2003, vol. 7 No. 1, ISPUB. |
Oncu and Sakarya: Central Venous Catheter—Related Infections: An Overview with Special Emphasis on Diagnosis. Prevention and Management. The Internet Journal of Anesthesiology. 2003, vol. 7 No. 1, ISPUB. |
Papageorgiou et al. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br. J. Dermatol. 142, 973-978 (2000). |
Reed et al. Central venous catheter infections: concepts and controversies. Intensive Care Med. 21, 177-183 (1995). |
Safdar et al. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann. Intern. Med. 142, 451-466 (2005). |
Simon et al. Infection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United States. J. Neurosurg. Pediatr. 4, 156-165 (2009). |
Sitges-Serra et al. Pathogenesis and prevention of catheter-related septicemia. Am. J. Infect. Control 23, 310-316 (1995). |
Timsit et al. New materials and devices for preventing catheter-related infections. Ann. Intensive Care 1, 34 (2011). |
Vermeulen et al. The bactericidal effect of ultraviolet and visible light on Escherichia coli. Biotechnol. Bioeng. 99, 550-556 (2008). |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE49416E1 (en) | 2009-11-20 | 2023-02-14 | Corning Incorporated | Optical fiber illumination systems and methods |
US20190175937A1 (en) * | 2012-04-05 | 2019-06-13 | Nathaniel L.R. Rhodes | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US11529530B2 (en) * | 2012-04-05 | 2022-12-20 | Light Line Medical, Inc. | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US10238890B2 (en) * | 2012-04-05 | 2019-03-26 | Light Line Medical, Inc. | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US10471277B2 (en) * | 2012-04-05 | 2019-11-12 | Light Line Medical, Inc. | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US20180043180A1 (en) * | 2012-04-05 | 2018-02-15 | Nathaniel L. Rhodes | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity |
US11491345B2 (en) * | 2013-02-07 | 2022-11-08 | Rocomp Global, Llc | Electromagnetic radiation targeting devices, assemblies, systems and methods |
US20160038621A1 (en) * | 2013-03-14 | 2016-02-11 | Teleflex Medical Incorporated | Optical fiber based antimicrobial ultraviolet radiation therapy system |
US10765768B2 (en) | 2013-03-14 | 2020-09-08 | Teleflex Medical Incorporated | Optical fiber based antimicrobial ultraviolet radiation therapy system |
US10293065B2 (en) * | 2013-03-14 | 2019-05-21 | Teleflex Medical Incorporated | Optical fiber based antimicrobial ultraviolet radiation therapy system |
US10786585B2 (en) | 2013-11-26 | 2020-09-29 | Corning Incorporated | Anti-bacterial light delivery system and method for disinfecting a surface |
US11213695B2 (en) | 2013-11-26 | 2022-01-04 | Corning Incorporated | Illuminated bandage and method for disinfecting a wound |
US10582843B2 (en) | 2015-03-24 | 2020-03-10 | Corning Incorporated | Illuminating surgical device having light diffusing fiber |
US11617895B2 (en) | 2015-07-28 | 2023-04-04 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
US11524173B2 (en) | 2015-07-28 | 2022-12-13 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
US10856952B2 (en) | 2015-08-21 | 2020-12-08 | Corning Incorporated | Medical device disinfecting system and method |
US10543058B2 (en) | 2015-08-21 | 2020-01-28 | Corning Incorporated | Medical device disinfecting system and method |
US11724124B2 (en) | 2015-11-06 | 2023-08-15 | Illuminoss Medical, Inc. | Systems and methods for anti-microbial effect for bones |
US10549114B2 (en) | 2016-02-03 | 2020-02-04 | Corning Incorporated | Therapeutic illumination assemblies and methods of illuminating medical devices and biological material using the same |
US11786751B2 (en) | 2016-02-03 | 2023-10-17 | Corning Incorporated | Therapeutic illumination assemblies and methods of illuminating medical devices and biological material using the same |
US11241585B2 (en) * | 2016-02-05 | 2022-02-08 | Light Line Medical, Inc. | Method and apparatus for removable catheter visual light therapeutic system |
US10918770B2 (en) | 2016-02-12 | 2021-02-16 | Corning Incorporated | Vacuum assisted wound closure assembly and methods of irradiating a wound using the same |
US11159730B2 (en) * | 2016-09-02 | 2021-10-26 | Trumpf Maschinen Austria Gmbh & Co. Kg. | Bending machine comprising a work area image detecting device and method for representing a work area |
US11327213B2 (en) | 2017-10-24 | 2022-05-10 | Corning Incorporated | Light diffusing optical fibers having uniform illumination along diffusion lengths and methods of forming the same |
US11850314B2 (en) | 2018-01-16 | 2023-12-26 | Corning Incorporated | Illumination of light diffusing optical fibers, illumination of blue-violet light delivery systems, blue-violet light delivery systems, and methods for blue-violet light induced disinfection |
US10992078B2 (en) | 2018-01-29 | 2021-04-27 | Bard Access Systems, Inc. | Connection system for establishing an electrical connection through a drape and methods thereof |
US11936132B2 (en) | 2018-01-29 | 2024-03-19 | Bard Access Systems, Inc. | Connection system for establishing an electrical connection through a drape and methods thereof |
US11786620B2 (en) | 2018-04-30 | 2023-10-17 | CathBuddy, Inc. | Handheld cleaner-disinfector for medical devices |
US10639389B2 (en) | 2018-04-30 | 2020-05-05 | CathBuddy, Inc | Methods and devices for portable sterilization and containment of medical devices |
US11617807B2 (en) | 2018-04-30 | 2023-04-04 | CathBuddy, Inc. | Urinary intermittent catheter |
US11583600B2 (en) | 2018-04-30 | 2023-02-21 | CathBuddy, Inc. | Methods and devices for portable sterilization and containment of medical devices |
US11617808B2 (en) | 2018-04-30 | 2023-04-04 | CathBuddy, Inc. | Catheter insertion aid for use with a urinary intermittent catheter |
US11304772B2 (en) * | 2018-05-18 | 2022-04-19 | Bard Access Systems, Inc. | Connection systems and methods thereof for establishing an electrical connection through a drape |
US11628030B2 (en) * | 2018-05-18 | 2023-04-18 | Bard Access Systems, Inc. | Connection systems and methods thereof for establishing an electrical connection through a drape |
US20190350663A1 (en) * | 2018-05-18 | 2019-11-21 | Bard Access Systems, Inc. | Connection Systems And Methods Thereof For Establishing An Electrical Connection Through A Drape |
US10772696B2 (en) * | 2018-05-18 | 2020-09-15 | Bard Access Systems, Inc. | Connection systems and methods thereof for establishing an electrical connection through a drape |
US20230248459A1 (en) * | 2018-05-18 | 2023-08-10 | Bard Access Systems, Inc. | Connection Systems and Methods Thereof for Establishing an Electrical Connection Through a Drape |
US20220241044A1 (en) * | 2018-05-18 | 2022-08-04 | Bard Access Systems, Inc. | Connection Systems and Methods Thereof for Establishing an Electrical Connection Through a Drape |
US11726273B2 (en) | 2018-12-21 | 2023-08-15 | Corning Incorporated | Light diffusing multi-fiber design configured for use with UV LEDs |
US11737848B2 (en) | 2019-07-29 | 2023-08-29 | Bard Access Systems, Inc. | Connection systems and methods for establishing optical and electrical connections through a drape |
US11752359B2 (en) | 2020-03-19 | 2023-09-12 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11684798B2 (en) | 2020-03-19 | 2023-06-27 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11229728B1 (en) * | 2020-08-24 | 2022-01-25 | Light Line Medical, Inc. | Method and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation in a dialysis system |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
US11904130B2 (en) | 2021-03-23 | 2024-02-20 | University Of Washington | Fluid access devices and methods |
US11813368B2 (en) | 2021-08-27 | 2023-11-14 | Abl Medical Inc. | Anti-microbial blue light systems and methods |
Also Published As
Publication number | Publication date |
---|---|
US10729916B2 (en) | 2020-08-04 |
US10471277B2 (en) | 2019-11-12 |
US20130267888A1 (en) | 2013-10-10 |
US20180043180A1 (en) | 2018-02-15 |
US11529530B2 (en) | 2022-12-20 |
US20190175937A1 (en) | 2019-06-13 |
US10238890B2 (en) | 2019-03-26 |
US20200206529A1 (en) | 2020-07-02 |
US20180056089A1 (en) | 2018-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11529530B2 (en) | Methods and apparatus to inactivate infectious agents on a drainage catheter residing in a body cavity | |
US10307612B2 (en) | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity | |
CA3071998C (en) | Methods and apparatus to deliver therapeutic, non-ultra violet electromagnetic radiation to inactivate infectious agents | |
US11229808B2 (en) | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation versatilely via a catheter residing in a body cavity | |
JP5938408B2 (en) | UV-C antibacterial device for infusion therapy | |
EP1284789B1 (en) | Apparatus to prevent infections | |
US20240024698A1 (en) | Method, system, and devices of safe, antimicrobial light-emitting catheters, tubes, and instruments | |
US10894173B2 (en) | Methods and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation to inactivate infectious agents and/or to enhance healthy cell growth via a catheter residing in a body cavity | |
US20230075669A1 (en) | Light delivery system with a fiber optic disposable for preventing, reducing and/or eliminating infections during institutional or in-home use | |
US11229728B1 (en) | Method and apparatus to deliver therapeutic, non-ultraviolet electromagnetic radiation in a dialysis system | |
JP3246227U (en) | Method and apparatus for variably delivering therapeutic non-ultraviolet electromagnetic radiation via a catheter placed within a body cavity | |
US20240016246A1 (en) | Near field safe antimicrobial wavelength disinfection via optical fibers, light guides, or light pipes for percutaneous or indwelling ambulatory disinfection of catheters, vascular access lines, drains, endo-tracheal tubes and similar medical devices | |
WO2022248691A1 (en) | System for disinfecting skin tissue around catheters |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: VERITAS MEDICAL, L.L.C., UTAH Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:RHODES, NATHANIEL L.R.;BRACKEN, ADAM E.;DE LA PRESA, MARTIN;AND OTHERS;SIGNING DATES FROM 20130405 TO 20130410;REEL/FRAME:030384/0252 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
AS | Assignment |
Owner name: LIGHT LINE MEDICAL, INC., UTAH Free format text: CHANGE OF NAME;ASSIGNOR:VERITAS MEDICAL, L.L.C.;REEL/FRAME:045041/0003 Effective date: 20170804 |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Year of fee payment: 4 |