|Publication number||US9731075 B2|
|Application number||US 14/126,104|
|Publication date||15 Aug 2017|
|Filing date||14 Jun 2012|
|Priority date||17 Jun 2011|
|Also published as||CA2838786A1, CN103732278A, CN103732278B, EP2720738A1, EP2720738B1, US20140121606, WO2012171981A1|
|Publication number||126104, 14126104, PCT/2012/61249, PCT/EP/12/061249, PCT/EP/12/61249, PCT/EP/2012/061249, PCT/EP/2012/61249, PCT/EP12/061249, PCT/EP12/61249, PCT/EP12061249, PCT/EP1261249, PCT/EP2012/061249, PCT/EP2012/61249, PCT/EP2012061249, PCT/EP201261249, US 9731075 B2, US 9731075B2, US-B2-9731075, US9731075 B2, US9731075B2|
|Inventors||Michael Jugl, Torsten Kraft, Daniel Vogt, Axel Forstreuter|
|Original Assignee||Sanofi-Aventis Deutschland Gmbh|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (137), Non-Patent Citations (3), Classifications (7), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present application is a U.S. National Phase Application pursuant to 35 U.S.C. §371 of International Application No. PCT/EP2012/061249 filed Jun. 14, 2012, which claims priority to European Patent Application No. 11170308.8 filed Jun. 17, 2011. The entire disclosure contents of these applications are herewith incorporated by reference into the present application.
The present invention relates to the field of drug delivery devices and in particular to injection devices such like pen-type injectors for administering a predefined dose of a liquid medicament.
Drug delivery devices allowing for multiple dosing of a required dosage of a liquid medicament, such as liquid drugs, and further providing administration of the medicament to a patient, are as such well-known in the art. Generally, such devices have substantially the same purpose as that of an ordinary syringe.
Drug delivery devices of this kind have to meet a number of user specific requirements. For instance in case of those with diabetes, many users will be physically infirm and may also have impaired vision. Therefore, these devices need to be robust in construction, yet easy to use, both in terms of the manipulation of the parts and understanding by a user of its operation. Further, the dose setting must be easy and unambiguous and where the device is to be disposable rather than reusable, the device should be inexpensive to manufacture and easy to dispose. In order to meet these requirements, the number of parts and steps required to assemble the device and an overall number of material types the device is made from have to be kept to a minimum.
Typically, the medicament to be administered is provided in a cartridge that has a moveable piston or bung mechanically interacting with a piston rod of a drive mechanism of the drug delivery device. By applying thrust to the piston in a distal direction, a predefined amount of the medicinal fluid is expelled from the cartridge.
In particular for elderly or physically infirm users, the overall handling of the device in a home medication environment should be simple and highly reliable. As for instance illustrated in
The cartridge holder 12 further comprises an insert portion 26 at its proximal end section, by way of which the cartridge holder 12 can be at least partially inserted into a correspondingly shaped distal receptacle of a proximal housing component 14 of the drug delivery device, typically denoted as body 14. The body 14 serves to accommodate a drive mechanism having a piston rod to become operably engaged with a piston of a cartridge to be disposed and fixed in the cartridge holder 12. By way of the inspection window 24, the fluid or filling level of the cartridge can be visually inspected.
The known device 10 as illustrated in
Radially inwardly protruding prongs 34 further comprise a beveled surface 36 towards their distal end in order to facilitate mutual engagement of prongs 34 and through openings 28. Furthermore, the insert portion 26 of the cartridge holder 12 is delimited in distal direction by a circumferential and radially outwardly extending rim 30, which in a final assembly configuration abuts against a distally located end face 38 of the body 14.
The housing components 12, 14 are typically manufactured as injection moulded plastic components, which, by virtue of appropriately selected thermoplastic materials feature a sufficient elasticity in order to support the snapping in and a resulting positive interconnection of cartridge holder 12 and body 14.
However, since such drug delivery devices 10 are predominately intended for home medication, the device has to fulfill highest possible standards in terms of failure safety and robustness, especially in view of mechanical impact.
If for instance the device 10 drops down from a considerably height, a mechanical load-distribution may rise above a critical level in the interconnection of cartridge holder 12 and body 14. Point stresses or point loading acting on the through opening 28 and/or on the prongs 34 may exceed a critical level and the interconnection of cartridge holder 12 and body 14 may break down, the housing components 12, 14 may release and the device 1 would be no longer of use.
It is therefore an object of the present invention to provide a drug delivery device comprising a robust, reliable and mechanically resistant interconnection of cartridge holder and body. The interconnection should be easily integrable in existing housing designs of drug delivery devices. It should also be easily implementable, both, in terms of production costs and assembly work. Moreover, the interconnection of body and cartridge holder should be intuitive and easy to establish.
The present invention relates to a drug delivery device for administering a predefined dose of a medicament. The drug delivery device, typically designed as pen-type injector comprises a housing having at least two components, a proximally located body to accommodate a drive mechanism and a distally located cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction. The drive mechanism to be arranged in the body typically has a displaceable piston rod, which is adapted to operably engage with the piston of the cartridge. This way, the piston rod can exert distally directed thrust to the piston for expelling a predefined amount of the medicament from the cartridge via a distally located seal, which is typically to be penetrated by an injection needle.
Cartridge holder and body are to be directly interconnected by way of an interconnection. The interconnection is preferably of positive-engaging type and has at least one displaceable or resiliently deformable latch element which is adapted to mate and to engage with a corresponding bearing. The latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of body or cartridge holder. Typically, body and cartridge holder are of substantially cylindrical or tubular shape. The at least one latch element is therefore adapted to establish a positive interlock between cartridge holder and body by way of which a snap-in- or engaging motion can exclusively take place in the plane defined by the circumferential side walls of body or cartridge holder.
Such circumferentially directed displacement or deformation of the at least one latch element is beneficial in that mutually corresponding insert portions or receptacle portions of body and cartridge holder no longer have to provide a through opening in a circumferential side wall portion that is to engage with radially inwardly or outwardly extending prongs or the like. Hence, the circumferential displacement or deformation of the at least one latch element supports a modified and more robust design of side wall portions of cartridge holder and body. Consequently, side wall sections of said housing components that form the interconnection of cartridge holder and body can be designed free of through openings and/or latch elements.
Also, respective side wall portions of cartridge holder and body can be designed as substantially closed surfaces inherently providing increased mechanical strength, reliability and failure safety in the event of considerable mechanical impact.
Preferably, the interconnection is established by a plurality of mutually corresponding and mutually mating latch elements and bearings, that are preferably integrated or integrally formed with said housing components, cartridge holder and body.
In a preferred embodiment, cartridge holder and/or body, in particular the interconnection between cartridge holder and body comprise an insert portion and a corresponding receptacle portion for establishing an at least partially interleaved interconnection of cartridge holder and body. This way, a cartridge holder portion for instance acting as insert portion can be inserted into a receptacle portion of the body. Respective insert and receptacle portions then at least partially overlap in radial direction when a final assembly configuration is attained.
Preferably, the cartridge holder comprises the insert portion at a proximal end section and the body comprises the receptacle portion at a distal end section. This way, the cartridge holder can be at least partially inserted into the body in order to establish a positive interconnection of said housing components. However, the design of the drug delivery device is not limited to such configurations. It is generally conceivable, that the cartridge holder comprises a receptacle portion adapted to receive an insert portion of the body.
According to a further embodiment, the insert portion comprises the at least one latch element extending in longitudinal direction (z) and having at least one resiliently deformable spreading piece extending in circumferential direction (w). It may be of further benefit, when the latch element longitudinally extends from a distal end of the insert portion. Preferably, a plurality of latch elements is provided at the distal end face of the insert portion in order to intercept or to distribute mechanical impact across the circumference of the insert portion.
In a further preferred aspect, the receptacle portion comprises the at least one bearing, which extends in a lateral plane (x, y) with respect to a tubular shape of cartridge holder and/or body. Preferably, the bearing extends substantially perpendicular to the longitudinal extent of body, cartridge holder and/or insert portion and respective latch elements.
The bearing is preferably integrally formed with the receptacle portion of the body and may further delimit the receptacle portion in proximal direction. Therefore, the at least one bearing, typically extending radially inwardly from an inside facing side wall section of the body and/or of its receptacle is preferably integrally formed with the body. By way of the bearing extending in the lateral plane, any longitudinally or axially directed force effect transferred via the longitudinally extending latch element can be transferred to the bearing and may further conducted and transferred to the closed shape side wall structure of the body.
In a further preferred aspect, the bearing comprises at least one axial through opening to receive the at least one latch element of the insert portion. Preferably, the latch element may resiliently deform in order to pass through the bearing's through opening. Thereafter, circumferentially extending spreading pieces of the latch element may appropriately spread, thus preventing to retract the latch element. The latch element may also comprise an arrow-like design, wherein respective beveled shaped spreading barbs substantially inhibit a release of the interconnection of latch element and bearing. In a relaxed configuration, the through opening of the bearing is therefore smaller than the circumferential extent of the latch element. The latch element, in particular its spreading pieces or barbs have to be resiliently squeezed in order to pass through the bearing's through opening or receptacle.
The through opening of the bearing can be arranged adjacent a circumferential side wall of the receptacle portion. It may also be arranged at a radial distance from the side wall portion.
According to another embodiment, the bearing adjacently extends to an inside facing side wall section of the receptacle portion and further comprises a central through opening to axially guide a piston rod of the drive mechanism. The central through opening may be threaded in order to cooperate with an outer thread of the piston rod. Alternatively, the central through opening of the bearing or web may also comprise a radially extending groove or protrusion to mate with a radially extending rotation inhibiting protrusion or groove of the piston rod.
According to another embodiment, the latch element and the corresponding bearing are integrated in at least one longitudinally extending rib and groove of mutually engaging side wall sections of insert portion and receptacle portion of cartridge holder and body, respectively. When side wall sections of insert portion and receptacle portion are provided with mutually corresponding ribs and grooves, a torsion-resistant interconnection of body and cartridge holder can be attained.
Moreover, by way of mutually corresponding tongues and grooves in or on side wall sections of body and cartridge holder, a mutual interconnection of said housing components requires a respective rotative alignment of body and cartridge holder prior to an insertion of insert portion into the receptacle portion. Additional or adjacent to the above-described latching element, also the groove and the corresponding rib can be equipped with mutually corresponding latch elements and bearings. For instance, the longitudinal groove may comprise a circumferentially extending bearing or a respective recess adapted to mate and to engage with circumferentially extending latch elements of the rib.
Preferably, the rib and/or the groove extend in radial direction with respect to mutually corresponding side wall sections of insert portion and receptacle portion. In particular, the rib or a correspondingly shaped tongue may radially outwardly protrude from a lateral side wall section of the insert portion. Accordingly or alternatively, the rib may also extend radially inwardly from an inward facing side wall section of the receptacle portion. A corresponding and cooperating groove adapted to receive said rib is provided in the corresponding inner or outer side wall section of the receptacle or the insert portion.
In a further preferred aspect, the bearing adapted to mate with the at least one latch element comprises at least one undercutting circumferentially extending in the groove. The undercutting is designed and configured to cooperate with a spreading piece or barb of the latch element extending in circumferential direction.
It is of further benefit, when according to another embodiment side wall sections of the insert portion and/or of the receptacle portion comprise a substantially closed surface structure, which is substantially free of through openings or comparative structurally weakened areas. This way, side wall sections of insert portion and receptacle portion of body and cartridge holder can be structurally strengthened, such that they become less prone to fracture in response to mechanical impact or shock.
In a further aspect, the interconnection to be established between cartridge holder and body is of non-releasable type. Hence, once an interconnection has been established, a non-destructive release of said housing component is neither intended nor possible. Upon consumption of the medicament provided in a cartridge, the drug delivery device is intended to be discarded in its entirety.
According to another preferred aspect, the drug delivery device is equipped with a pre-filled cartridge arranged in the cartridge holder. The cartridge is at least partially filled with an injectable medicament. Also, the drug delivery device is further equipped with a drive mechanism arranged in the body, ready to exert distally directed thrust to the cartridge's piston for the purpose of precisely expelling a predefined dose or amount of the medicament.
The term “medicament,” as used herein, means a pharmaceutical formulation containing at least one pharmaceutically active compound,
wherein in one embodiment the pharmaceutically active compound has a molecular weight up to 1500 Da and/or is a peptide, a proteine, a polysaccharide, a vaccine, a DNA, a RNA, a antibody, an enzyme, an antibody, a hormone or an oligonucleotide, or a mixture of the above-mentioned pharmaceutically active compound,
wherein in a further embodiment the pharmaceutically active compound is useful for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism, acute coronary syndrome (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis and/or rheumatoid arthritis,
wherein in a further embodiment the pharmaceutically active compound comprises at least one peptide for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy,
wherein in a further embodiment the pharmaceutically active compound comprises at least one human insulin or a human insulin analogue or derivative, glucagon-like peptide (GLP-1) or an analogue or derivative thereof, or exedin-3 or exedin-4 or an analogue or derivative of exedin-3 or exedin-4.
Insulin analogues are for example Gly(A21), Arg(B31), Arg(B32) human insulin; Lys(B3), Glu(B29) human insulin; Lys(B28), Pro(B29) human insulin; Asp(B28) human insulin; human insulin, wherein proline in position B28 is replaced by Asp, Lys, Leu, Val or Ala and wherein in position B29 Lys may be replaced by Pro; Ala(B26) human insulin; Des(B28-B30) human insulin; Des(B27) human insulin and Des(B30) human insulin.
Insulin derivates are for example B29-N-myristoyl-des(B30) human insulin; B29-N-palmitoyl-des(B30) human insulin; B29-N-myristoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl-ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-Y-glutamyl)-des(B30) human insulin; B29-N-(N-lithocholyl-Y-glutamyl)-des(B30) human insulin; B29-N-(ω-carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(ω-carboxyheptadecanoyl) human insulin.
Exendin-4 for example means Exendin-4(1-39), a peptide of the sequence H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.
Exendin-4 derivatives are for example selected from the following list of compounds:
Hormones are for example hypophysis hormones or hypothalamus hormones or regulatory active peptides and their antagonists as listed in Rote Liste, ed. 2008, Chapter 50, such as Gonadotropine (Follitropin, Lutropin, Choriongonadotropin, Menotropin), Somatropine (Somatropin), Desmopressin, Terlipressin, Gonadorelin, Triptorelin, Leuprorelin, Buserelin, Nafarelin, Goserelin.
A polysaccharide is for example a glucosaminoglycane, a hyaluronic acid, a heparin, a low molecular weight heparin or an ultra low molecular weight heparin or a derivative thereof, or a sulphated, e.g. a poly-sulphated form of the above-mentioned polysaccharides, and/or a pharmaceutically acceptable salt thereof. An example of a pharmaceutically acceptable salt of a poly-sulphated low molecular weight heparin is enoxaparin sodium.
Pharmaceutically acceptable salts are for example acid addition salts and basic salts. Acid addition salts are e.g. HCl or HBr salts. Basic salts are e.g. salts having a cation selected from alkali or alkaline, e.g. Na+, or K+, or Ca2+, or an ammonium ion N+(R1)(R2)(R3)(R4), wherein R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1-C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group, or an optionally substituted C6-C10-heteroaryl group. Further examples of pharmaceutically acceptable salts are described in “Remington's Pharmaceutical Sciences” 17. ed. Alfonso R. Gennaro (Ed.), Mark Publishing Company, Easton, Pa., U.S.A., 1985 and in Encyclopedia of Pharmaceutical Technology.
Pharmaceutically acceptable solvates are for example hydrates.
It will be further apparent to those skilled in the pertinent art that various modifications and variations can be made to the present invention without departing from the spirit and scope of the invention. Further, it is to be noted, that any reference signs used in the appended claims are not to be construed as limiting the scope of the present invention.
In the following, preferred embodiments of the invention will be described by making reference to the drawings, in which:
The latch mechanism 59 attainable by the embodiment as illustrated in
The latch elements 68 as illustrated in
Position and circumferential distribution of the latch elements 68 corresponds with the circumferential size and position of the axial through openings 58 of the bearing 54. The bearing 54 as further illustrated in
The latch elements 68 as shown in
Typically, the longitudinal extension of the insert portion 66 substantially matches with the longitudinal extension of the receptacle portion 51. When a final assembly configuration of the drug delivery device is attained, cartridge holder 60 and body 50 not only abut in radial direction but also in longitudinal direction (z). It is intended, that a distal and lower end face of the body abuts 50 in longitudinal direction with a radially extending circumferential rim 64 of the cartridge holder 60. Correspondingly, also a proximally located end face of the insert portion 66 may but against the transverse or laterally extending bearing 54 in final assembly configuration. The circumferential rim 64 further separates a distal and substantially tubular shaped portion 62 of the cartridge holder 12 and the insert portion 66.
The embodiment according to
Here, it is of further benefit, when the circumferentially protruding barbs or spreading pieces 84 comprise a sufficient elasticity that allows to urge the latch elements 82 through the groove 86 in longitudinal direction (z) until a final assembly configuration as illustrated in
The embodiment according to
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3790048 *||28 Jul 1972||5 Feb 1974||Ortho Pharma Corp||Incremental dose dispenser|
|US4266541 *||17 Sep 1979||12 May 1981||Halen-Elliot Do Brazil Industria E Comercio Equipamentos De Precisao Ltda.||Pressure hypodermic injector for intermittent vaccination|
|US4425120 *||15 Apr 1982||10 Jan 1984||Sampson Norma A||Shielded hypodermic syringe|
|US4581022 *||1 Nov 1983||8 Apr 1986||Micro-Mega S.A.||Dental syringe|
|US4710178 *||11 Sep 1986||1 Dec 1987||Micro-Mega S.A.||Precision injection system and method for intraligmental anesthesia|
|US4731059 *||14 Oct 1986||15 Mar 1988||Medical Safety Products, Inc.||Combination needle shield/needle guard device positively locked onto detachable needle assemblies for an evacuated blood collection system and a hypodermic syringe|
|US4865591 *||10 Jun 1988||12 Sep 1989||Hypoguard (Uk) Limited||Measured dose dispensing device|
|US4900311 *||6 Dec 1988||13 Feb 1990||Lawrence Stern||Hypodermic syringe|
|US4917673 *||31 Oct 1988||17 Apr 1990||Coplin Allan J||Assembly for the protection against inadvertent puncture by medical needles|
|US4923446 *||14 Apr 1988||8 May 1990||Page Mary J||Shield for devices capable of penetrating skin|
|US4966592 *||5 May 1989||30 Oct 1990||Burns Cameron A||Protective sleeve for hypodermic needle|
|US4973318 *||9 Feb 1989||27 Nov 1990||D.C.P. Af 1988 A/S||Disposable syringe|
|US5112317 *||18 Jan 1989||12 May 1992||Nosta Ag||Injection device|
|US5137511 *||16 Nov 1989||11 Aug 1992||Duoject Medical Systems Inc.||Syringe|
|US5279585 *||4 Feb 1992||18 Jan 1994||Becton, Dickinson And Company||Medication delivery pen having improved dose delivery features|
|US5346480 *||14 Dec 1992||13 Sep 1994||Q-Med, Inc.||Syringe with retractable needle|
|US5545147 *||20 Oct 1992||13 Aug 1996||Eli Lilly And Company||Anti-backup improvement for hypodermic syringes|
|US5569190 *||3 Jun 1994||29 Oct 1996||D'antonio; Nicholas F.||Hypodermic fluid dispenser|
|US5573513 *||26 May 1993||12 Nov 1996||Sterimatic Holdings Limited||Prefilled cartridge syringe with needle system|
|US5591138 *||10 Aug 1995||7 Jan 1997||Vaillancourt; Vincent L.||Protected needle assembly|
|US5595566 *||8 Dec 1995||21 Jan 1997||Unique Management Enterprises, Inc.||Apparatus for shielding a syringe needle|
|US5643214 *||13 May 1994||1 Jul 1997||Owen Mumford Limited||Injection devices|
|US5674204 *||19 Sep 1995||7 Oct 1997||Becton Dickinson And Company||Medication delivery pen cap actuated dose delivery clutch|
|US5688241 *||15 Apr 1996||18 Nov 1997||Asbaghi; Hooman Ali||Automatic non-reusable needle guard|
|US5713857 *||28 Jun 1996||3 Feb 1998||Becton Dickinson France, S.A.||Sequential stopper|
|US5851197 *||5 Feb 1997||22 Dec 1998||Minimed Inc.||Injector for a subcutaneous infusion set|
|US5921966 *||11 Aug 1997||13 Jul 1999||Becton Dickinson And Company||Medication delivery pen having an improved clutch assembly|
|US5938642 *||23 Jan 1998||17 Aug 1999||Eli Lilly And Company||Multiple dose medication dispensing device|
|US6068614 *||31 Oct 1995||30 May 2000||Astra Pharmaceuticals Pty, Ltd.||Plastic syringe with overcap|
|US6599272 *||12 May 2000||29 Jul 2003||Pharmacia Ab||Injection device and method for its operation|
|US6634076 *||3 May 2002||21 Oct 2003||Pharmacia Ab||Structure and method for joining parts|
|US6884237 *||10 Dec 2002||26 Apr 2005||Inviro Medical Devices, Inc.||Position guide for a needle guard|
|US7094221 *||2 Mar 2004||22 Aug 2006||Dca Design International Ltd.||Drive mechanisms suitable for use in drug delivery devices|
|US7169132 *||1 Oct 2003||30 Jan 2007||Becton, Dickinson And Company||Medication delivery pen|
|US7195616 *||8 May 2002||27 Mar 2007||Eli Lilly And Company||Medication injector apparatus with drive assembly that facilitates reset|
|US7241278 *||22 Sep 2003||10 Jul 2007||Novo Nordisk A/S||Injection device|
|US7427275 *||28 Sep 2007||23 Sep 2008||Eli Lilly And Company||Medication dispensing apparatus with triple screw threads for mechanical advantage|
|US7481977 *||6 Sep 2001||27 Jan 2009||Bio-Rad Laboratories, Inc.||Assay device|
|US7771398 *||30 Dec 2005||10 Aug 2010||Wockhardt Ltd.||Pen shaped medication injection devices|
|US7850662 *||21 Jan 2009||14 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US7918833 *||11 Jul 2006||5 Apr 2011||DCA Design International, Ltd||Pen-type injector|
|US7935088 *||14 Sep 2006||3 May 2011||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US7985201 *||26 Mar 2002||26 Jul 2011||Dca Design International Limited||Relating in and relating to an injection device|
|US7993301 *||15 May 2009||9 Aug 2011||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US8128594 *||3 Nov 2010||6 Mar 2012||Chang li-feng||Safety syringe|
|US8257319 *||27 May 2010||4 Sep 2012||Sanofi-Aventis Deutschland Gmbh||Drug delivery device inner housing having helical spline|
|US8945063 *||17 Jan 2014||3 Feb 2015||Antares Pharma, Inc.||Hazardous agent injection system|
|US9108031 *||23 Sep 2009||18 Aug 2015||Fresenius Kabi Deutschland Gmbh||Connector having a membrane, for connecting a syringe to a container or tubing|
|US9220660 *||15 Jul 2011||29 Dec 2015||Antares Pharma, Inc.||Liquid-transfer adapter beveled spike|
|US9242047 *||16 Feb 2012||26 Jan 2016||Sanofi-Aventis Deutschland Gmbh||Detent mechanism|
|US9358341 *||29 Sep 2010||7 Jun 2016||Sanofi-Aventis Deutschland Gmbh||Resettable drug delivery device|
|US9446195 *||28 Jun 2013||20 Sep 2016||Antares Pharma, Inc.||Injection device with cammed ram assembly|
|US20010031949 *||10 May 2001||18 Oct 2001||Asbaghi Hooman A.||Protective device for a prefilled injection syringe|
|US20020004652 *||25 Apr 2001||10 Jan 2002||Asbaghi Hooman A.||Protective device for a fillable injection syringe|
|US20020133122 *||7 Feb 2002||19 Sep 2002||Lucio Giambattista||Pen needle and safety shield system|
|US20030050609 *||22 Mar 2001||13 Mar 2003||Bernard Sams||One-way clutch mechanisms and injector devices|
|US20030105430 *||8 Nov 2002||5 Jun 2003||Elan Pharma International Limited Wil House||Automatic injector|
|US20030144630 *||28 Jan 2002||31 Jul 2003||Chang Yu Kang||Safety syringe|
|US20040111064 *||10 Dec 2002||10 Jun 2004||Asbaghi Hooman A.||Position guide for a needle guard|
|US20040127858 *||1 Oct 2003||1 Jul 2004||Becton, Dickinson And Company||Medication delivery pen|
|US20040153003 *||10 Dec 2003||5 Aug 2004||Chris Cicenas||Biopsy device with sample tube|
|US20040210199 *||8 May 2002||21 Oct 2004||Atterbury William Goodwin||Medication injector apparatus with drive assembly that facilitates reset|
|US20040249348 *||22 Mar 2004||9 Dec 2004||Steven Wimpenny||Dose dial and drive mechanisms suitable for use in drug delivery devices|
|US20040260247 *||2 Mar 2004||23 Dec 2004||Robert Frederick Veasey||Drive mechanisms suitable for use in drug delivery devices|
|US20050033244 *||3 Mar 2004||10 Feb 2005||Veasey Robert Frederick||Drive mechanisms suitable for use in drug delivery devices|
|US20060069354 *||30 Sep 2004||30 Mar 2006||Buenger David R||Syringe activation device|
|US20060189933 *||18 Feb 2005||24 Aug 2006||Becton, Dickinson And Company||Safety shield system for a syringe|
|US20060206057 *||9 Aug 2004||14 Sep 2006||Eli Lily And Company Patent Division||Medication dispensing apparatus with triple screw threads for mechanical advantage|
|US20060264839 *||11 Jul 2006||23 Nov 2006||Dca Design International Ltd.||Pen-type injector|
|US20070123829 *||31 Jan 2007||31 May 2007||Atterbury William G||Medication injector apparatus with drive assembly that facilitates reset|
|US20080027397 *||28 Sep 2007||31 Jan 2008||Deruntz Otto D||Medication dispensing apparatus with triple screw threads for mechanical advantage|
|US20080262436 *||24 Nov 2005||23 Oct 2008||Shl Medical Ab||Injection Device|
|US20090005742 *||4 Jan 2007||1 Jan 2009||Barry Peter Liversidge||Medical Needle Safety Device|
|US20090024093 *||20 Apr 2006||22 Jan 2009||Franck Carrel||Protection device for protecting an injection needle|
|US20090198193 *||21 Jan 2009||6 Aug 2009||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US20090264828 *||22 Jan 2009||22 Oct 2009||Christoph Dette||Drug Delivery Device Dose Setting Mechanism|
|US20100094205 *||15 May 2009||15 Apr 2010||Sanofi-Aventis Deutschland Gmbh||Dosing and Drive Mechanism for Drug Delivery Device|
|US20100094206 *||15 May 2009||15 Apr 2010||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US20100094207 *||15 May 2009||15 Apr 2010||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US20100094253 *||15 May 2009||15 Apr 2010||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US20100106098 *||6 Jan 2010||29 Apr 2010||William Godwin Atterbury||Medication Injector Apparatus with Drive Assembly that Facilitates Reset|
|US20100114038 *||26 Oct 2007||6 May 2010||Bernard Sams||Medicine delivery apparatus|
|US20100137792 *||2 Dec 2008||3 Jun 2010||Sanofi-Aventis Deutschland Gmbh||Medication delivery device and method for operating a medication delivery device|
|US20100268170 *||25 Sep 2008||21 Oct 2010||Becton Dickinson France S.A.S.||Autoinjector|
|US20100286623 *||19 Jul 2010||11 Nov 2010||Tip-Top.Com Ltd||Medical Needle Safety Device|
|US20100324494 *||27 May 2010||23 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drug delivery device last dose lock-out mechanism|
|US20100324496 *||27 May 2010||23 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Dose setting mechanism for priming a drug delivery device|
|US20100324497 *||27 May 2010||23 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Biasing mechanism for a drug delivery device|
|US20100324527 *||27 May 2010||23 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drug delivery dose setting mechanism with variable maximum dose|
|US20100331788 *||27 May 2010||30 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Resettable drug delivery device|
|US20100331790 *||27 May 2010||30 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Spindle for a drug delivery device|
|US20100331791 *||27 May 2010||30 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drug delivery device with dose dial sleeve rotational stop|
|US20100331792 *||27 May 2010||30 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drug delivery device inner housing having helical spline|
|US20100331806 *||27 May 2010||30 Dec 2010||Sanofi-Aventis Deutschland Gmbh||Drive mechanism for a drug delivery device|
|US20110034902 *||19 Dec 2008||10 Feb 2011||Tom Hede Markussen||Injection device for delivering a fixed dose of liquid drug|
|US20110118667 *||13 Nov 2009||19 May 2011||Becton Dickinson And Company||Hub Assembly Having A Hidden Needle For A Drug Delivery Pen|
|US20110152784 *||3 Mar 2011||23 Jun 2011||Robert Frederick Veasey||Pen-type injector|
|US20110319832 *||24 Jun 2010||29 Dec 2011||Thomas Chun||Protective guard for needles of injection devices having removable needle assemblies|
|US20110319833 *||24 Jun 2010||29 Dec 2011||Thomas Chun||Protective guard for needles of injection devices|
|US20120010575 *||9 May 2009||12 Jan 2012||Sanofi-Aventis Deutschland Gmbh||Drive assembly suitable for use in a drug delivery device and drug delivery device|
|US20120010576 *||19 Jan 2010||12 Jan 2012||Sanofi-Aventis Deutschland Gmbh||Drive assembly and medication delivery device|
|US20120022462 *||18 Dec 2009||26 Jan 2012||Sanofi-Aventis Deutschland Gmbh||Drug delivery device|
|US20120041368 *||23 Apr 2010||16 Feb 2012||Shl Group Ab||Safety Pen Needle Device|
|US20120046643 *||18 Dec 2009||23 Feb 2012||Sanofi-Aventis Deutschland Gmbh||Injection device|
|US20120089098 *||21 Dec 2009||12 Apr 2012||Sanofi-Avetnis Deutschland Gmbh||Drug Delivery Device|
|US20120089100 *||11 Nov 2010||12 Apr 2012||Dca Design International Ltd||Pen-Type Injector|
|US20120165752 *||24 Aug 2010||28 Jun 2012||Shl Group Ab||Dose Reset Mechanism|
|US20120172816 *||30 Jun 2011||5 Jul 2012||Malcolm Boyd||Drive Mechanisms Suitable for Use in Drug Delivery Devices|
|US20120283649 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drive mechanism for a drug delivery device and use of a reset member for a drive mechanism|
|US20120283651 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drive Mechanism for a Drug Delivery Device and Resilient Element for a Drive Mechanism|
|US20120283652 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Assembly and Piston Rod for a Drug Delivery Device|
|US20120283653 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Assembly for a Drug Delivery Device|
|US20120283654 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Button Member for Operating a Drive Assembly|
|US20120283655 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drug delivery device and drive member for a drug delivery device|
|US20120283658 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Resettable drug delivery device|
|US20120283661 *||3 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drive Mechanism for Drug Delivery Device|
|US20120283662 *||29 Sep 2010||8 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Method for Assembling a Drug Delivery Device, Assembly for a Drug Delivery Device and Piston Rod for a Drug Delivery Device|
|US20120289907 *||29 Sep 2010||15 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drive Assembly, Piston Rod, Drug Delivery Device, and Use of a Spring|
|US20120289908 *||29 Sep 2010||15 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Resettable Drive Assembly and Drug Delivery Device|
|US20120296286 *||3 Sep 2010||22 Nov 2012||Sanofi-Aventis Deutschland Gmbh||Drive mechanism for a medication delivery device and medication delivery device|
|US20120310168 *||29 Sep 2010||6 Dec 2012||Sanofi-Aventis Deutschland Gmbh||Drug Delivery Device|
|US20120310206 *||29 Sep 2010||6 Dec 2012||Sanofi-Aventis Deutschland Gmbh||Injection Device|
|US20130018327 *||6 Dec 2010||17 Jan 2013||Sanofi-Aventis Deutschland Gmbh||Drive assembly for a drug delivery device and drug delivery device|
|US20130030409 *||29 Sep 2010||31 Jan 2013||Sanofi-Aventis Deutschland Gmbh||Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device|
|US20130184653 *||23 Sep 2011||18 Jul 2013||Eli Lilly And Company||Gearing mechanism for a dose delivery device|
|US20130204186 *||23 Mar 2011||8 Aug 2013||Sanofi-Aventis Deutschland Gmbh||Medicated module with automatic reservoir engagement|
|US20130211338 *||21 Jun 2011||15 Aug 2013||Sanofi-Aventis Deutschland Gmbh||Safety device for a pre-filled syringe and injection device|
|US20130289518 *||11 Oct 2011||31 Oct 2013||Sanch-Aventis Deutschland GmbH||Dose Setting Mechanism and Method of Using the Same|
|US20130324938 *||16 Feb 2012||5 Dec 2013||Sanofi-Aventis Deutschland Gmbh||Detent Mechanism|
|US20140012208 *||22 Mar 2012||9 Jan 2014||Sanofi-Aventis Deutschland Gmbh||Drug delivery device|
|US20140316347 *||30 Jun 2014||23 Oct 2014||Sanofi-Aventis Deutschland Gmbh||Drive mechanisms suitable for use in drug delivery devices|
|US20160206825 *||3 Sep 2014||21 Jul 2016||Sanofi||Pen type drug injection device with dose limiting nut to prevent setting of a dose higher than the amount of drug remaining|
|DKWO2011060785A1 *||Title not available|
|EP1683537A1||25 Jan 2005||26 Jul 2006||Pfizer Health AB||Injection device for administering a medication liquid|
|WO2008003560A1||7 Jun 2007||10 Jan 2008||Novo Nordisk A/S||Coupling for injection devices|
|WO2009137486A1||5 May 2009||12 Nov 2009||Becton, Dickinson And Company||Drug delivery device having cartridge with enlarged distal end|
|WO2011060785A1 *||19 Nov 2010||26 May 2011||Moeller Claus Schmidt||Injection device without a gearing|
|1||International Search Report for Int. App. No. PCT/EP2012/061249, completed Aug. 22, 2012.|
|2||*||Opening Defintion, Merriam-Webster Incorporated, 2015.|
|3||*||Slot Defintion, Merriam-Webster Incorporated, 2015.|
|International Classification||A61M5/24, A61M5/315|
|Cooperative Classification||A61M5/31543, A61M2005/2407, A61M2005/2492, A61M5/31585, A61M5/24|
|13 Dec 2013||AS||Assignment|
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, GERMANY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JUGL, MICHAEL;KRAFT, TORSTEN;VOGT, DANIEL;AND OTHERS;SIGNING DATES FROM 20120706 TO 20120723;REEL/FRAME:031781/0446