US8615367B2 - Number coding for identification of subtypes of coded types of solid phase carriers - Google Patents
Number coding for identification of subtypes of coded types of solid phase carriers Download PDFInfo
- Publication number
- US8615367B2 US8615367B2 US13/071,055 US201113071055A US8615367B2 US 8615367 B2 US8615367 B2 US 8615367B2 US 201113071055 A US201113071055 A US 201113071055A US 8615367 B2 US8615367 B2 US 8615367B2
- Authority
- US
- United States
- Prior art keywords
- particles
- beads
- group
- subtypes
- summands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
Definitions
- the invention is in the field of encoded carriers for chemical entities.
- Solid phase carriers for multiplexed analysis of multiple analytes preferably are encoded using one of several available color coding methods (see U.S. Ser. No. 09/448,420, filed Nov. 23, 1999, entitled “Color-Encoding and In-Situ Interrogation of Matrix-Coupled Chemical Compounds”; U.S. Ser. No. 10/348,165, filed Jan. 21, 2003, entitled “Method of Controlling Solute Loading of Polymer Microparticles,” U.S. Pat. No.
- 4,499,052 “Apparatus for Distinguishing Multiple Subpopulations of Cells) to produce spectrally distinguishable carriers; or using chemical tagging methods such as those commonly employed for encoding of combinatorial libraries to produce carriers distinguishable by way of decoding these tags by one of several methods known in the art (see, e.g., U.S. Pat. No. 6,503,759 “Complex Combinatorial Chemical Libraries Encoded with Tags”).
- solid phase carriers are functionalized to display chemical entities such as nucleic acid probes or protein receptors, each such entity being uniquely associated with a code and defining a carrier type.
- the molecular analysis of multiple analytes is performed in accordance with the Random Encoded Array Detection (READTM) format, as described in U.S. application Ser. No. 10/204,799, filed on Aug. 23, 2002, entitled “Multianalyte Molecular Analysis Using Application-Specific Random Particle Arrays” using microparticles (“beads”) as the solid phase carriers.
- RTDTM Random Encoded Array Detection
- a method of encoding by providing multiple instances (“multiplicities”) of each distinguishable type of carrier within a set of N such types has been described in connection with a flow cytometric multiplexed immunoassay format (See U.S. Pat. No. 5,567,627—Lehnen). Although Lehnen states that larger numbers of analytes may be analyzed with this method, the examples relate to small numbers, N, of analytes, where N ranges from 2 to 4.
- the molecular analysis of multiple analytes generally must accommodate numbers of analytes in the range of tens of analytes, or about 10 ⁇ N ⁇ 100.
- An example is the multiplexed analysis of the 25 mutations in the cystic fibrosis transmembrane regulator gene designated by the American College of Medical Genetics (ACMG) for pan-ethnic carrier screening, requiring at least 25 pairs of probes to discriminate normal and variant alleles.
- each m k is bounded from below as a result of placing confidence intervals on assay scores.
- the random encoded array (READTM) format or equivalent assay formats requires minimal multiplicities in the range of 30-50 to ensure desirable confidence intervals on assay determinations.
- the number of carriers of any given type contained in aliquots of suspension of nominally equal volumes will display a statistical variation, requiring that values of individual multiplicities be selected so as to differ from one another by at least several standard deviations about each mean, and thus not be spaced too closely.
- N-coding when number coding (“N-coding”) is augmented by an additional code—such as chemical coding and specifically color coding (“C-coding”)—and when applied to represent a finite, known number of outcomes for each of a multiplicity of probe types included in a multiplexed analysis, it is practical and desirable.
- C-coding color coding
- N-coding permits the representation of a finite number of known or anticipated assay scores or outcomes for each of a multiplicity of types of probes or receptors included in the analysis.
- N-coding thus can be used to discriminate nucleic acid alleles by N-coded subtypes of carriers, each subtype displaying a probe matched to one of the known or anticipated alleles; specifically, N-coding can be used to discriminate normal and variant alleles by pairs of probes, one of these complementary to the normal (“wildtype”, W) allele and represented by a multiplicity m W , the other complementary to the variant (“V”) allele and represented by a multiplicity m V , where m V ⁇ m W but both alleles share one color code.
- N-coding also can be used to discriminate epitopes by N-coded subtypes of carriers, each subtype displaying a receptor capable of binding to one of the known or anticipated epitopes of a ligand of interest, all such epitopes or ligands sharing one color code.
- Number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code.
- Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied advantageously, for example, in multiplexed nucleic acid or protein analysis.
- members of a pair of probes are encoded by N-coding of solid phase carriers of the same color, but each of several such different pairs of probes will be associated with a carrier type of a different color.
- This embodiment is useful, for example, in multiplexed mutation analysis, where a color code can be augmented (effectively doubled) by N-coding carriers displaying pairs of probes, where the pair members are complementary to, respectively, a wild-type and variant allele.
- sets of probes complementary, for example, to a polymorphic region and to each of the four possible bases at a designated polymorphic position within the region are encoded by N-coding of solid phase carriers of the same color, and each of several such different sets of probes will be associated with a carrier type of a different color.
- proteins (peptides) representing epitopes can be associated with a solid phase carrier and used to screen biological samples for reactive proteins or antibodies. This may be used, for example, where pairs or small sets of epitopes are associated with a particular antigen.
- the C-coding can be augmented by N-coding of solid phase carriers of the same color, where such a carrier subset carries the pairs or set of proteins corresponding to such pairs or sets of epitopes, as applicable.
- the solid phase carriers preferably are microparticles which are assembled into planar arrays of particles on a substrate for use in the Random Encoded Array Detection (READTM) format of analysis, as disclosed in Ser. No. 10/032,657, filed Dec. 28, 2001, entitled “Multianalyte Molecular Analysis Using Application-Specific Random Particle Arrays” (incorporated by reference).
- RSDTM Random Encoded Array Detection
- the methods herein are particularly useful in applications requiring, for each analyte, the determination of one among only a finite number of possible assay scores.
- N-coding of pairs of solid phase carriers is practical because only a small number of carrier subtypes, and in the case of mutation analysis only two carrier subtypes, need be distinguished, and a unique code is trivially available.
- FIGS. 1A to 1D show assay results of numerical coding for detecting the F508 mutation using elongation detection, in the form of a series of four histograms, where, in each histogram, the number of beads displaying a signal of a certain intensity is plotted against intensity.
- FIG. 2 depicts the native conformation of a protein which can be bound to either of two antibodies; the generation of synthetic peptide fragments corresponding to different linear epitopes of the protein and attaching the fragments to beads; and, the binding of labeled antibodies to the peptide fragments on the beads.
- a labeled secondary antibody could be used for detection, if the peptide fragments were initially bound by an unlabeled antibody (not shown).
- FIG. 3 depicts a coding system with four different C-codes (“colors”) to encode bead types, for use in detecting antibodies against eight different peptides (P1 to P8).
- FIG. 4 depicts a histogram showing the number of beads displaying a certain intensity as a function of intensity, for detection of the “V” and “W” alleles using different numbers of carriers displaying probes which bind to the V or the W alleles.
- the histogram has two distinct, non-overlapping peaks.
- FIG. 5 depicts a plot of results as show in FIG. 4 , but for overlapping histogram peaks in this case.
- FIG. 6 is a histogram representing the probability of selecting a given number of carriers (“beads”) of particular types of 70 subtypes, based on the evaluation of 40 random encoded arrays of beads, where the anticipated number of beads of each type was about 60. A total of about 3,500 beads (of 70 types) are anticipated to be present in each of the 40 bead arrays, based on an average 90% occupation of available sites. For each type, the CV was calculated over the population of 40 arrays evaluated.
- beads the number of carriers
- FIG. 7 is a histogram plot as in FIG. 6 , but for another type of beads.
- FIG. 8 is a plot of confidence interval against number of beads, at different CVs and significance levels ( ⁇ ).
- FIG. 9 is Table 1, showing results from three synthetic peptides P6, P8, and P12 affixed to the same colored microspheres in separate reactions.
- FIG. 10 is Table 2, showing bead types with different peptide pairs associated with beads.
- FIG. 11-13 are, respectively, Table 3A to 3C, showing beads reactive with different samples.
- N-Coding of Pairs (“Doublets”: Mutation Analysis and Carrier Screening—In the multiplexed analysis of mutations, a pair of probes is provided for each mutation of interest, a first probe designed to identify the “Wild-Type” (“W”) and a second probe designed to identify the “Variant” (“V”). Identification may invoke hybridization (as disclosed in U.S. application Ser. No. 10/847,046, filed May 17, 2004 “Hybridization-Mediated Analysis of Polymorphisms (hMAP),” both being incorporated herein by reference) or elongation (as disclosed in U.S. application Ser. No. 10/271,602, filed Oct. 15, 2002 entitled “Multiplexed Analysis of Polymorphic Loci by Concurrent Interrogation and Enzyme-Mediated Detection,” incorporated herein by reference).
- hMAP Hybridization-Mediated Analysis of Polymorphisms
- n C W and n C V are selected so as to differ by a quantity ⁇ n C , which is sufficiently large to ensure that an unambiguous call can be made in view of the practical considerations and requirements discussed above.
- the selection criterion for n C W and n C V is discussed in greater detail below.
- Each pair of probes can encounter only three possible scenarios: the W allele, the V allele or a heterozygous (H) target.
- the actual outcome is determined by “counting, comparing and (optionally) confirming” as follows:
- the N-coding system also could be used to detect single-nucleotide polymorphisms (SNPs).
- SNPs single-nucleotide polymorphisms
- eMAPTM detection one would generate four different sets of probes, each complementary to the subsequence of interest but distinguished in that each different set would carry, at the 3′ terminal probe position juxtaposed to the SNP site, one of four different nucleotides: A, C, G or T.
- Each set of probes would be attached to a carrier to form a carrier subtype, and there would be different numbers of each such subtype. The possible outcomes in such case would multiply to one positive for each of a possible four, or any combination of two positives for heterozygotes.
- N-coding also could be used in assays for detecting the presence, in a sample, of antibodies capable of binding to peptides displayed on beads, or, in the reverse situation, for detecting peptides in a sample where the antibodies are displayed on beads.
- N-coding could be used for increasing the number of available codes, where, for example, color coding is used to discriminate among peptide-antibody combinations. That is, certain combinations can be encoded using carriers of the same color, by N-coding of such same-colored carriers to discriminate among such different combinations.
- An assay for detecting antibodies can be of particular utility for detecting auto-antibodies in a patient, in support of a diagnosis of autoimmune disease.
- N-coding is useful when beads of a single color are employed, but are functionalized to display three different peptides to detect antibodies in a sample directed against one or more of the peptides, each peptide representing one specific epitope of the cognate antigen.
- Different numbers of beads displaying each of the three peptides would be pooled; i.e., X beads display peptide P1, Y beads display peptide P2, and Z display peptide P3.
- the pooled beads are then placed in contact with a sample which may contain antibodies against one or more of the peptides P1, P2 or P3.
- the sample is removed, and the beads are exposed to a labeled, secondary detection antibody which binds to any antibodies bound to the peptides on the beads (e.g., a goat anti-human antibody, if the sample is human); the assay signals are then recorded.
- the assay would have been first calibrated so that differences in relative signal can be correlated with numbers of labeled beads; i.e., one would be able to determine, based on the relative signal, whether X, Y, Z or a combination or sub-combination of X, Y and Z beads generated a signal, indicating they had bound to antibodies in the sample.
- the N-coding design in Table 2A may be used.
- Decoding the signal therefore, indicates which specific epitope (or epitopes, if the signal indicates that a combination or subcombination of X, Y and Z beads generated a signal) were recognized by antibodies in the sample. This will permit classification of autoantibodies into subtypes for each autoantigen.
- This assay system could also be used where a population of beads has uniquely encoded (e.g., C-coded) populations, N-coding can be enhanced to distinguish among a number of particles exceeding the number of available C-codes.
- C-coded bead populations are each associated with, respectively, proteins or peptides P1, P2, P3 and P4, and members of each bead type also are associated with proteins or peptides P5, P6, P7 and P8.
- the t-distribution provides an expression relating the values (w, Overline ⁇ I W ⁇ , S w 2 ) and (v, Overline ⁇ I V ⁇ , S v 2 ) to the desired probabilities that confidence intervals constructed from the two sets of observations and placed on the mean values of the observed intensities contain the true mean values ⁇ I W > and ⁇ I V >.
- the t-distribution can be applied in this circumstance to test whether the means of the two intensity populations are the same (or not) (see e.g, Chapt. 9 in “Principles of Statistics”, M. G. Bulmer, Dover Publications, 1979, incorporated by reference).
- FIG. 8 shows the confidence interval for cases where the assay CV is 10% and 30%.
- the interval defining the range of the calculated mean is plotted against the minimum number of beads N B necessary for significance levels of 90%, 95% and 99%. A larger number of beads ensures that the confidence interval is smaller.
- N-coding In contrast to other encoding methods such as C-coding, N-coding is subject to additional uncertainty as a result of peak overlap and equivalent ambiguities affecting recorded assay signal intensities. Thus, referring to N-coding of pairs in the context of mutation analysis, partitioning into + and ⁇ subtypes may not be obvious by mere inspection of the data, as presumed in the Count-Compare-Confirm procedure of determining subtypes.
- the numbers p and n will then differ from the numbers w of particles displaying a probe matching the W-allele and v of particles displaying a probe matching the V-allele. Accordingly, to ensure robust N-coding, the choice of w and v must be such that peak overlap will not corrupt the code ( FIG. 5 ).
- N-coding is preferably used only when it can be ensured that the N-coded subtypes produce substantially different assay signal intensities, thereby minimizing peak overlap.
- N-coding in accordance with the present invention preferably is used to represent discrete outcomes of an assay such that overlap between partitions in an intensity histogram is negligible. This is ensured by employing N-coding to represent assay outcomes only when the observed mean assay signal intensities are separated by at least one standard deviation, and preferably three standard deviations, to minimize the maximal number of possible false negatives or false positives. Alternatively, if a peak overlap of magnitude ⁇ is anticipated, w and v must be chosen in accordance with a design criterion such as the one stated above.
- N-coding is then particularly useful in connection with a color code (“C-code”) because it reduces the set of color codes required for encoding of a given number of probes. For example, for the ACMG panel of 25 CF mutations requiring, instead of 50 color codes, only 25 color codes are required. Conversely, N-coding extends by a factor of two the coding complexity of a given set of color codes, thereby facilitating the process of manufacturing sets of color-encoded particles.
- C-code color code
- N codes are constructed in accordance with the design rules outlined above, N coding can be used as part of a coding system involving color or other encoding markers, for certain of the carriers in a larger group, where such carriers are encoded identically but for their number codes.
- Mutation analysis was performed by placing members of a probe pair, designed to detect wild type and the ⁇ F 508 cystic fibrosis (“CF”) mutation on beads of the same color, but selecting different numbers of V-beads and W-beads. Assay results were analyzed by recording signal intensities indicating hybridization of probe and target, and by analyzing these results in accordance with the histogram representation and CCC procedure described herein. Protocols—Wild type (W) and mutant (V) probes relating to the ⁇ F 508 CF mutation fixed to beads of the same color, and beads were pooled at different ratios of W to V probes and assembled into planar arrays in accordance with the READTM format. On a first chip, the ratio of W:V was 1:5, and on a second chip the ratio of W:V was 5:1.
- eMAP elongation assay
- G3H a blue-green tosylated bead modified with Bovine Serum Albumin (“BSA”) in accordance with the methods disclosed in a co-pending application was functionalized with each of the following amino-modified DNA probes:
- a total of four arrays were assembled on the upper surface of a substrate (a “chip”), where two of these arrays were composed of Pool A, and the other two were composed of Pool B.
- RNA samples 6.5 ⁇ L PCR product was extracted from known WT or M samples and placed into a PCR tube, to which 2 ⁇ L Exo-sap was added. The mixture was incubated at 37° C. for 25 min and 80° C. for 15 min (in a thermocycler). Thereafter, ⁇ exonuclease was used for digestion into single stranded DNA.
- the reaction mixture included each of: dGTP, dTTP, dATP and dCTP.
- Ex-10 primers were used in multiplexed PCR:
- SEQ ID NO. 3 GGC GTC CCA AAA GGG TCA GTG AGC CTT CAG AGG GTA AAA T
- SEQ ID NO. 4 GCG GTC CCA AAA GGG TCA GTC AGT AGC TTA CCC ATA GAG G
- FIGS. 1A to 1D The results of the assay are shown in FIGS. 1A to 1D , in the form of a series of four histograms.
- the number of beads displaying a signal of a certain intensity is plotted against intensity.
- a wild-type (“W”) sample is added to a bead pool in which the ratio of the number of beads functionalized with probes complementary to the W subsequence to that of beads functionalized with probes complementary to the variant (“V”) is 1 to 5.
- the histogram has two peaks, but, as expected, the peak corresponding to the beads producing a positive signal has only a small area, indicating that only a small number of beads produce a positive signal.
- the sample is the same, but the ratio of beads of each type is reversed, and, as expected, the reverse ratio of peak areas is observed in the histogram.
- the sample is heterozygous for W and V, and, as expected, irrespective of the ratio of V and W, a large number of beads produce a positive signal.
- Beadchips were incubated in separate experiments with two 1:20 diluted serum samples positive for antibody directed against a lupus characteristic antigen, SCL-70 (#1764 from Bios Pacific and #68933 from METIC Lab. After removing non-reacted antibodies, specific antibodies captured by the peptides were visualized using a fluorescently labeled goat-anti-human IgG antibody-conjugate. Decoding and assay images were acquired using a microscope equipped with a CCD camera, as in the previous example. The assay signals were extracted, and the Pi/P7 ratios (peptide-specific signal intensity vs. the signal intensity of negative control peptide, P7) were calculated. Beads with an intensity value significantly higher than that of the negative control were designated positive.
- P6, P8 or P12-specific antibodies was determined by the relative numbers of positive beads. As shown in Table 1 ( FIG. 9 ), assaying sample #1764 yielded 300 positive beads, meaning the positive beads captured anti-P8 (100 positive beads) and anti-P12 (200 positive beads) antibodies. Sample #68933 yielded 150 positive beads, meaning the positive beads captured anti-P6 (50 positive beads) and anti-P8 (100 positive beads) antibodies.
- a 0.5 ⁇ l aliquot of pooled bead suspension is placed onto a planar silicon substrate, covering an area of approximately 1 mm 2 which includes a designated area of 300 ⁇ m by 300 ⁇ m, thus approximately 10% of the total area, for assembly of a planar array of 4000.
- sample aliquot
- reservoir aliquot
- bead types will be distributed about the mean value, say the average density of particles in the original volume of suspension, in accordance with a Poisson distribution such as those shown in FIGS. 6 and 7 .
Abstract
Description
Count the number of carriers, p := nC+, (of, e.g., type C) which score |
positive, as determined from the intensity of signal recorded after |
completion of an assay designed to detect the presence of the W and/or |
V form of the subsequence of interest; Count the number of carriers, |
n := nc−, (of type C) which score negative; |
Compare: |
IF: |
p/w ~ 1: | THEN: W-allele; |
Confirm: n/v ~ 1; |
IF NOT, THEN IF |
p/v ~ 1: | THEN: V-allele; |
Confirm: n/w ~ 1; |
IF NOT, THEN IF |
p/(w+v) ~ 1: | THEN: H; |
Confirm: n/(w+v) ~ 0; |
N-Coding of Multiplets: Polymorphisms and Antibody/Epitope Pairs
Confidence Intervals—A finite variance in assay signals recorded from carriers of different type will of course affect the reliability of discrimination between W and V alleles regardless of the method of coding. Thus, the standard methods of statistical analysis apply to the construction of confidence intervals—once the step of partitioning of the carrier population into types has been accomplished.
Construct a histogram of intensities recorded from all carriers sharing |
one C-code; |
IF (histogram has only a single peak such that : n+/(w + v) ~ 1) THEN: H |
ELSE find an optimal threshold, T, such that: |
(n+(T) − w){circumflex over ( )}2 = min AND (n− (T) − v){circumflex over ( )}2 = min THEN: W allele |
OR |
(n+(T) − v){circumflex over ( )}2 = min AND (n− (T) − w){circumflex over ( )}2 = min THEN: V allele |
wherein n+(T) and n−(T) are obtained by integration over the two |
partitions produced by partitioning of the histogram in accordance with |
the selection of the threshold T. |
IF (without overlap: p > n) | THEN ensure p − e > n + e | ||
with overlap. | |||
ELSE IF (without overlap: p < n) | THEN ensure p + e < n − e | ||
with overlap | |||
IF (N-code is to ensure v* < w*) : | ||
THEN select v, w such that v + δv < w − δw | ||
ELSE IF (N-code is to ensure v* > w*) : | ||
THEN select v, w such that v − δv > w + δw | ||
IF (N-code is to ensure ( |p−w*| < |p−v*| ) AND |
( |n−v*| < |n−w*| ) | /* W |
allele */ |
THEN ensure | max{ |p ±e − w*| } < min{ |p ± e − v*| }AND |
max{ |n ±e − v*| } < min{ |n ± e − w*| } |
ELSE IF (N-code is to ensure ( |p−v*| < |p−w*| ) AND |
( |n−w*| < |n−v*| ) | /* V |
allele */ |
THEN ensure | max{ |p ±e − v*| } < min{ |p ±e − w*| } AND |
max{ |n ±e − w*| } < min{ |n±e − v*| } | |
508W: | |
(SEQ ID NO. 1) |
Sequence: | GGC ACC ATT AAA GAA AAT ATC ATC | |
ΔF 508: | |
(SEQ ID NO. 2) |
Sequence: | GGC ACC ATT AAA GAA AAT ATC ATT |
The following protocol was used to attach these probes to the BSA-modified beads.
BSA Protocol:
-
- 1. Add 100 μL of beads to a tube containing 500 μL PBST, mix with vortex
- 2. Centrifuge for 1 min and remove the supernatant
- 3. Add 500 μL MES (0.1M, pH 4.5), mix with vortex,
- 4. Centrifuge for 1 min and remove supernatant
- 5. Prepare 0.05M of EDAC in MES right before use:
- a. Take EDAC out of freezer and let it warm to room temperature for 30 min
- b. Add 4 mL of MES (0.1M, pH 4.5) to 40 mg EDAC, mix with vortex
- 6. Add 500 μL of EDAC solution to each tube of beads
- 7. Add 10 μL probe (100 μM) to each bead suspension
- 8. Allow the beads to react for 1 hour at room temperature with end-over-end mixing
- 9. Add 100 μL of PBST to each tube after reaction, mix with vortex, centrifuge for 1 min, and remove supernatant
- 10. Wash beads twice with 500 μL of PBST and resuspend the beads in 100 μl, of TBS-2.
Bead Pooling:
-
- 1. Add each of the four modified beads to an empty tube according to the volumes noted below
- 2. Wash beads once in 100
μL 10 mM Tris - 3. Resuspend beads in 36 μl, 10 mM Tris
Pool A:
Bead | Volume added (μL) | ||
G3H- | 1 | ||
G3H- | 5 | ||
G4B-OligoC-2 | 15 | ||
G1E- | 15 | ||
Pool B:
Bead | Volume added (μL) | ||
G3H- | 5 | ||
G3H- | 1 | ||
G4B-OligoC-2 | 15 | ||
G1E- | 15 | ||
Assembly of Random Encoded Bead Arrays:
SEQ ID NO. 3: |
GGC GTC CCA AAA GGG TCA GTG AGC CTT CAG AGG GTA |
AAA T |
SEQ ID NO. 4: |
GCG GTC CCA AAA GGG TCA GTC AGT AGC TTA CCC ATA |
GAG G |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/071,055 US8615367B2 (en) | 2003-09-18 | 2011-03-24 | Number coding for identification of subtypes of coded types of solid phase carriers |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50429403P | 2003-09-18 | 2003-09-18 | |
US10/943,760 US7927796B2 (en) | 2003-09-18 | 2004-09-17 | Number coding for identification of subtypes of coded types of solid phase carriers |
US13/071,055 US8615367B2 (en) | 2003-09-18 | 2011-03-24 | Number coding for identification of subtypes of coded types of solid phase carriers |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/943,760 Division US7927796B2 (en) | 2003-09-18 | 2004-09-17 | Number coding for identification of subtypes of coded types of solid phase carriers |
Publications (2)
Publication Number | Publication Date |
---|---|
US20110184655A1 US20110184655A1 (en) | 2011-07-28 |
US8615367B2 true US8615367B2 (en) | 2013-12-24 |
Family
ID=34375473
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/943,760 Expired - Fee Related US7927796B2 (en) | 2003-09-18 | 2004-09-17 | Number coding for identification of subtypes of coded types of solid phase carriers |
US13/071,055 Expired - Fee Related US8615367B2 (en) | 2003-09-18 | 2011-03-24 | Number coding for identification of subtypes of coded types of solid phase carriers |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/943,760 Expired - Fee Related US7927796B2 (en) | 2003-09-18 | 2004-09-17 | Number coding for identification of subtypes of coded types of solid phase carriers |
Country Status (2)
Country | Link |
---|---|
US (2) | US7927796B2 (en) |
WO (1) | WO2005029705A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6411210B2 (en) * | 2014-12-26 | 2018-10-24 | 富士通コンポーネント株式会社 | Touch panel unit |
US11140298B2 (en) * | 2019-12-19 | 2021-10-05 | City University Of Hong Kong | Universal color coding system, and a system and a method of manipulating colors using such color coding system |
Citations (493)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3329638A (en) | 1963-09-05 | 1967-07-04 | Monsanto Co | Multilayered polymeric latices with hydrophilic surface layer |
US3574614A (en) | 1967-01-06 | 1971-04-13 | Xerox Corp | Process of preparing multiple copies from a xeroprinting master |
US3790492A (en) | 1971-03-11 | 1974-02-05 | Atomic Energy Commission | Method for production of uniform microspheres |
US3957741A (en) | 1974-01-17 | 1976-05-18 | California Institute Of Technology | Crosslinked, porous, polyacrylate beads |
US3982182A (en) | 1973-08-13 | 1976-09-21 | Coulter Electronics, Inc. | Conductivity cell for particle study device |
US3989775A (en) | 1971-03-01 | 1976-11-02 | Bakelite Xylonite Limited | Method of making a retro-reflective beaded material |
US3998525A (en) | 1973-10-26 | 1976-12-21 | American Cyanamid Company | Edge lighted electrochromic displays |
US4003713A (en) | 1975-08-14 | 1977-01-18 | Bowser Everett N | Multiple test tube evaporator |
US4046667A (en) | 1975-10-30 | 1977-09-06 | Pen Kem, Inc. | Microelectrophoresis apparatus |
US4055799A (en) | 1975-01-23 | 1977-10-25 | Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung | Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells |
US4075013A (en) | 1976-09-13 | 1978-02-21 | Ward Anthony T | Electrophotochemical preparation of selenium photoconductive members |
US4102990A (en) | 1977-12-05 | 1978-07-25 | General Electric Company | Electrophoretic assay for antigen-antibody reaction based on particle-particle coupling |
US4140937A (en) | 1975-07-22 | 1979-02-20 | Aron Vecht | Direct current electroluminescent devices |
US4143203A (en) | 1976-03-19 | 1979-03-06 | Amicon Corporation | Particulate support material |
US4199363A (en) | 1974-09-17 | 1980-04-22 | Eastman Kodak Company | Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions |
US4258001A (en) | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
US4267235A (en) | 1979-03-19 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde microspheres |
US4275053A (en) | 1975-08-14 | 1981-06-23 | Mt. Sinai School Of Medicine Of The City University Of New York | Blood cell typing and compatibility test procedure |
US4326008A (en) | 1976-08-27 | 1982-04-20 | California Institute Of Technology | Protein specific fluorescent microspheres for labelling a protein |
US4336173A (en) | 1978-02-21 | 1982-06-22 | Sintef | Process for preparing an aqueous emulsion or dispersion of a partly water-soluble material, and optionally further conversion of the prepared dispersion or emulsion to a polymer dispersion when the partly water-soluble material is a polymerizable monomer |
US4339337A (en) | 1979-08-24 | 1982-07-13 | Rhone-Poulenc Industries | Process for the preparation of magnetic beads of vinylaromatic polymers |
US4358388A (en) | 1980-04-18 | 1982-11-09 | Rhone Poulenc Industries | Magnetic polymer latex and preparation process |
US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4421896A (en) | 1979-11-13 | 1983-12-20 | The Dow Chemical Company | Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products formed therefrom |
US4456513A (en) | 1981-09-10 | 1984-06-26 | Yoshio Kawai | Method of and apparatus for measuring electrophoretic mobility |
US4487855A (en) | 1983-02-15 | 1984-12-11 | Shih Yen Jer | Colored latexes; methods for making same and colored finely divided products |
US4497208A (en) | 1983-06-23 | 1985-02-05 | Matec, Inc. | Measurement of electro-kinetic properties of a solution |
US4499052A (en) | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
US4575407A (en) | 1962-12-03 | 1986-03-11 | Diller Isaac M | Product and process for the activation of an electrolytic cell |
US4591550A (en) | 1984-03-01 | 1986-05-27 | Molecular Devices Corporation | Device having photoresponsive electrode for determining analytes including ligands and antibodies |
US4602989A (en) | 1985-09-17 | 1986-07-29 | Dorr-Oliver Incorporated | Method and apparatus for determining the zeta potential of colloidal particles |
US4613559A (en) | 1985-04-01 | 1986-09-23 | Xerox Corporation | Process for colored toner compositions with controlled charges thereon |
US4647544A (en) | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
US4654267A (en) | 1982-04-23 | 1987-03-31 | Sintef | Magnetic polymer particles and process for the preparation thereof |
US4663408A (en) | 1985-12-30 | 1987-05-05 | Exxon Research And Engineering Company | Tetrapolymers of N-vinyl pyrrolidone/acrylamide/salt of acrylic acid/N-alkyl acrylamide |
US4665020A (en) | 1984-05-30 | 1987-05-12 | United States Department Of Energy | Flow cytometer measurement of binding assays |
US4672040A (en) | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
US4680332A (en) | 1986-01-24 | 1987-07-14 | Xerox Corporation | Ink jet compositions and process for preparation thereof |
US4679439A (en) | 1985-09-17 | 1987-07-14 | Dorr-Oliver Incorporated | Method and apparatus for measuring the unsteady sedimentation potential of colloidal particles |
US4702598A (en) | 1985-02-25 | 1987-10-27 | Research Corporation | Flow cytometer |
US4717655A (en) | 1982-08-30 | 1988-01-05 | Becton, Dickinson And Company | Method and apparatus for distinguishing multiple subpopulations of cells |
US4753775A (en) | 1985-04-12 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Rapid assay processor |
US4774189A (en) | 1984-12-24 | 1988-09-27 | Flow Cytometry Standards Corp. | Fluorescent calibration microbeads simulating stained cells |
US4791310A (en) | 1986-10-02 | 1988-12-13 | Syracuse University | Fluorescence microscopy |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
CA1248873A (en) | 1983-05-19 | 1989-01-17 | Ioannis Tripatzis | Particles and procedures for the determination of antigens and/or antibodies using the particles |
US4806776A (en) | 1980-03-10 | 1989-02-21 | Kley Victor B | Electrical illumination and detecting apparatus |
US4806313A (en) | 1985-04-12 | 1989-02-21 | E. I. Du Pont De Nemours And Company | Rapid assay processor |
US4822746A (en) | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
US4824941A (en) | 1983-03-10 | 1989-04-25 | Julian Gordon | Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems |
US4829101A (en) | 1981-04-29 | 1989-05-09 | Rohm Gmbh | Polymer particles and latices thereof for the immobilization of biologically active substances |
US4832814A (en) | 1987-12-28 | 1989-05-23 | E. I. Du Pont De Nemours And Company | Electrofusion cell and method of making the same |
US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
US4873102A (en) | 1988-03-14 | 1989-10-10 | Manchium Chang | Magnetic particles |
US4891324A (en) | 1987-01-07 | 1990-01-02 | Syntex (U.S.A.) Inc. | Particle with luminescer for assays |
US4911806A (en) | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
US4920056A (en) | 1988-02-19 | 1990-04-24 | The Dow Chemical Company | Apparatus and method for automated microbatch reaction |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4996265A (en) | 1988-01-29 | 1991-02-26 | Mita Industrial Co., Ltd. | Process for preparation of monodisperse polymer particles having increased particle size |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
US5015452A (en) | 1986-11-17 | 1991-05-14 | Clarkson University | Process for synthesis of uniform colloidal particles of rare earth oxides |
US5028545A (en) | 1987-06-16 | 1991-07-02 | Wallac Oy | Biospecific multianalyte assay method |
US5073498A (en) | 1984-12-24 | 1991-12-17 | Caribbean Microparticles Corporation | Fluorescent alignment microbeads with broad excitation and emission spectra and its use |
US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
US5091206A (en) | 1987-10-26 | 1992-02-25 | Baxter Diagnostics Inc. | Process for producing magnetically responsive polymer particles and application thereof |
US5105305A (en) | 1991-01-10 | 1992-04-14 | At&T Bell Laboratories | Near-field scanning optical microscope using a fluorescent probe |
US5114864A (en) | 1986-06-25 | 1992-05-19 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations |
US5126239A (en) | 1990-03-14 | 1992-06-30 | E. I. Du Pont De Nemours And Company | Process for detecting polymorphisms on the basis of nucleotide differences |
US5128006A (en) | 1991-01-23 | 1992-07-07 | At&T Bell Laboratories | Deposition of diamond films on semicondutor substrates |
US5132097A (en) | 1987-02-11 | 1992-07-21 | G.D. Research | Apparatus for analysis of specific binding complexes |
US5132242A (en) | 1987-07-15 | 1992-07-21 | Cheung Sau W | Fluorescent microspheres and methods of using them |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5143853A (en) | 1986-06-25 | 1992-09-01 | Trustees Of Tufts College | Absorbance modulated fluorescence detection methods and sensors |
US5147777A (en) | 1990-06-18 | 1992-09-15 | Eastman Kodak Company | Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use |
US5155044A (en) | 1987-03-13 | 1992-10-13 | Coulter Electronics, Inc. | Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples |
US5173159A (en) | 1988-09-06 | 1992-12-22 | Bertin & Cie | Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates |
US5185066A (en) | 1988-08-11 | 1993-02-09 | Helena Laboratories Corporation | Immunofixation electrophoresis control system |
US5187096A (en) | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
EP0529775A1 (en) | 1991-06-28 | 1993-03-03 | Oki Electric Industry Co., Ltd. | Arraying process of ultra-small objects and fabrication process of ultra-fine structure by using the arraying process |
DE4035714C2 (en) | 1990-11-09 | 1993-03-04 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
US5194393A (en) | 1989-11-21 | 1993-03-16 | Bayar Aktiengesellschaft | Optical biosensor and method of use |
US5194300A (en) | 1987-07-15 | 1993-03-16 | Cheung Sau W | Methods of making fluorescent microspheres |
US5208111A (en) | 1990-08-25 | 1993-05-04 | Bayer Aktiengesellschaft | One- or multi-layered layer elements applied to supports and their production |
US5221417A (en) | 1992-02-20 | 1993-06-22 | At&T Bell Laboratories | Conductive adhesive film techniques |
US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
US5241012A (en) | 1987-05-19 | 1993-08-31 | Applied Immune Sciences, Inc. | Activated and conjugated polystyrene substrate |
US5244630A (en) | 1988-04-22 | 1993-09-14 | Abbott Laboratories | Device for performing solid-phase diagnostic assay |
US5244813A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
US5250264A (en) | 1991-01-25 | 1993-10-05 | Trustees Of Tufts College | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
US5252494A (en) | 1986-06-25 | 1993-10-12 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix |
US5254477A (en) | 1986-06-25 | 1993-10-19 | Trustees Of Tufts College | Flourescence intramolecular energy transfer conjugate compositions and detection methods |
US5266427A (en) | 1988-10-18 | 1993-11-30 | Nippondenso Co., Ltd. | Display board and method for producing the same |
US5266497A (en) | 1990-08-31 | 1993-11-30 | Japan Synthetic Rubber Co., Ltd. | Immunochromatographic assay with improved colored latex |
US5266238A (en) | 1990-12-24 | 1993-11-30 | American Cyanamid Company | Narrow band radiation filter films |
US5281370A (en) | 1990-08-22 | 1994-01-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of making solid crystalline narrow band radiation filter |
US5288577A (en) | 1991-02-27 | 1994-02-22 | Ricoh Company, Ltd. | Dry-type developer |
US5298741A (en) | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
US5301044A (en) | 1990-12-31 | 1994-04-05 | Xerox Corporation | Marking material containing a taggant, and method of producing an image |
US5306618A (en) | 1986-07-02 | 1994-04-26 | E. I. Du Pont De Nemours And Company | Method systems and reagents for DNA sequencing |
US5308586A (en) | 1992-05-01 | 1994-05-03 | General Atomics | Electrostatic separator using a bead bed |
US5308749A (en) | 1991-01-25 | 1994-05-03 | Eastman Kodak Company | Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use |
US5320814A (en) | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US5326691A (en) | 1991-11-21 | 1994-07-05 | John Hozier | Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries |
US5326692A (en) | 1992-05-13 | 1994-07-05 | Molecular Probes, Inc. | Fluorescent microparticles with controllable enhanced stokes shift |
US5329461A (en) | 1992-07-23 | 1994-07-12 | Acrogen, Inc. | Digital analyte detection system |
US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
US5356713A (en) | 1989-03-31 | 1994-10-18 | Rhone-Poulenc Chimie | Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology |
US5362653A (en) | 1989-09-12 | 1994-11-08 | Carr Robert J G | Examination of objects of macromolecular size |
US5364759A (en) | 1991-01-31 | 1994-11-15 | Baylor College Of Medicine | DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5382801A (en) | 1992-04-15 | 1995-01-17 | Agency Of Industrial Science And Technology | Method for producing minute particles and apparatus therefor |
US5382512A (en) | 1993-08-23 | 1995-01-17 | Chiron Corporation | Assay device with captured particle reagent |
US5389549A (en) | 1987-05-29 | 1995-02-14 | Toa Medical Electronics Co., Ltd. | Method for classifying leukocytes and a reagent used therefor |
US5395688A (en) | 1987-10-26 | 1995-03-07 | Baxter Diagnostics Inc. | Magnetically responsive fluorescent polymer particles |
US5405784A (en) | 1988-11-04 | 1995-04-11 | Chemunex | Agglutination method for the determination of multiple ligands |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US5415835A (en) | 1992-09-16 | 1995-05-16 | University Of New Mexico | Method for fine-line interferometric lithography |
US5422246A (en) | 1990-12-14 | 1995-06-06 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Electrode having a polymer coating with a redox enzyme bound thereto, the polymer coating being formed on the walls of pores extending through a porous membrane |
US5436327A (en) | 1988-09-21 | 1995-07-25 | Isis Innovation Limited | Support-bound oligonucleotides |
US5442246A (en) | 1992-09-29 | 1995-08-15 | Fujitsu Limited | Programmable logic circuit |
US5444330A (en) | 1990-02-26 | 1995-08-22 | Molecular Displays, Inc. | Electrochromic, electroluminescent and electrochemiluminescent displays |
US5447440A (en) | 1993-10-28 | 1995-09-05 | I-Stat Corporation | Apparatus for assaying viscosity changes in fluid samples and method of conducting same |
US5468649A (en) | 1994-02-15 | 1995-11-21 | Abbott Laboratories | Process for labeling acridinium to microparticles and application in an instrument |
US5470534A (en) | 1993-05-10 | 1995-11-28 | Hitachi, Ltd. | Analytical system useful in diagnosis of the condition of a disease |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5474895A (en) | 1990-11-14 | 1995-12-12 | Siska Diagnostics Inc. | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
US5480723A (en) | 1985-04-08 | 1996-01-02 | Optical Sensors Incorporated | Surface-bound fluorescent polymers and related methods of synthesis and use |
US5496997A (en) | 1994-01-03 | 1996-03-05 | Pope; Edward J. A. | Sensor incorporating an optical fiber and a solid porous inorganic microsphere |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5512157A (en) | 1993-06-21 | 1996-04-30 | Helena Laboratories Corporation | Electrophoresis plate |
US5512490A (en) | 1994-08-11 | 1996-04-30 | Trustees Of Tufts College | Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns |
US5512439A (en) | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
US5514785A (en) | 1990-05-11 | 1996-05-07 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
US5516635A (en) | 1991-10-15 | 1996-05-14 | Ekins; Roger P. | Binding assay employing labelled reagent |
US5518883A (en) | 1992-07-02 | 1996-05-21 | Soini; Erkki J. | Biospecific multiparameter assay method |
US5523231A (en) | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
US5527710A (en) | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
US5528392A (en) | 1993-06-07 | 1996-06-18 | Fuji Photo Film Co., Ltd. | Image-forming apparatus having liquid crystal and photoconductive members and using the same light beam for reading and writing |
US5532128A (en) | 1991-11-19 | 1996-07-02 | Houston Advanced Research Center | Multi-site detection apparatus |
US5536648A (en) | 1988-12-09 | 1996-07-16 | Amrad Corporation Limited | Amplified DNA assay using a double stranded DNA binding protein |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5552086A (en) | 1992-01-29 | 1996-09-03 | Coulter Corporation | Immobilized metal colloids on dispersed polymer microspheres |
US5552270A (en) | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5567627A (en) | 1991-07-16 | 1996-10-22 | Trans-Med Biotech, Incorporated | Method and composition for the simultaneous and discrete analysis of multiple analytes |
US5567304A (en) | 1995-01-03 | 1996-10-22 | Ibm Corporation | Elimination of island formation and contact resistance problems during electroetching of blanket or patterned thin metallic layers on insulating substrate |
US5582988A (en) | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5593839A (en) | 1994-05-24 | 1997-01-14 | Affymetrix, Inc. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US5602042A (en) | 1994-04-14 | 1997-02-11 | Cytyc Corporation | Method and apparatus for magnetically separating biological particles from a mixture |
US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5627040A (en) | 1991-08-28 | 1997-05-06 | Becton Dickinson And Company | Flow cytometric method for autoclustering cells |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5633724A (en) | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
US5633972A (en) | 1995-11-29 | 1997-05-27 | Trustees Of Tufts College | Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy |
US5637508A (en) | 1993-03-26 | 1997-06-10 | Geo-Centers, Inc. | Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same |
US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5643765A (en) | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5648124A (en) | 1993-07-09 | 1997-07-15 | Seradyn, Inc. | Process for preparing magnetically responsive microparticles |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
US5650488A (en) | 1991-09-18 | 1997-07-22 | British Technology Group Limited | Polypeptide inhibitor of the replication of HSV |
US5652107A (en) | 1993-01-15 | 1997-07-29 | The Public Health Research Institute Of The City Of New York, Inc. | Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase |
US5652059A (en) | 1991-11-20 | 1997-07-29 | Bar Ilan University | Method for attaching microspheres to a substrate |
US5653939A (en) | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5660990A (en) | 1995-08-18 | 1997-08-26 | Immunivest Corporation | Surface immobilization of magnetically collected materials |
US5667667A (en) | 1992-04-24 | 1997-09-16 | Isis Innovation Limited | Electrochemical treatment of surfaces |
US5674698A (en) | 1992-09-14 | 1997-10-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5674686A (en) | 1994-03-28 | 1997-10-07 | Promega Corporation | Allelic ladders for short tandem repeat loci |
US5679524A (en) | 1994-02-07 | 1997-10-21 | Molecular Tool, Inc. | Ligase/polymerase mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis |
US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5698271A (en) | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5714521A (en) | 1994-04-07 | 1998-02-03 | Yeda Research And Development Company Ltd. | Ion exchange membranes |
US5714340A (en) | 1992-12-22 | 1998-02-03 | Johnson & Johnson Clinical Diagnostics, Inc. | Immunoassay elements having a receptor zone |
US5716852A (en) | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
US5723218A (en) | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
US5723233A (en) | 1996-02-27 | 1998-03-03 | Lsi Logic Corporation | Optical proximity correction method and apparatus |
US5722470A (en) | 1995-11-09 | 1998-03-03 | Glaxo Group Limited | Bead dispensing device and methods |
US5728529A (en) | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
US5736349A (en) | 1989-09-29 | 1998-04-07 | Nippon Paint Co., Ltd. | Magnetic particle and immunoassay using the same |
US5744299A (en) | 1995-11-03 | 1998-04-28 | Mcw Research Foundation | Human parainfluenza virus-1 assay |
US5744305A (en) | 1989-06-07 | 1998-04-28 | Affymetrix, Inc. | Arrays of materials attached to a substrate |
US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US5763198A (en) | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
US5763175A (en) | 1995-11-17 | 1998-06-09 | Lynx Therapeutics, Inc. | Simultaneous sequencing of tagged polynucleotides |
US5766711A (en) | 1996-08-29 | 1998-06-16 | Barmakian; Andrew | Composite camel structure and method for manufacture |
US5766963A (en) | 1996-01-26 | 1998-06-16 | Pharmacopeia, Inc. | Combination hydroxypropylamine library |
US5770455A (en) | 1993-07-19 | 1998-06-23 | Ontogen Corporation | Methods and apparatus for synthesizing labeled combinatorial chemistrylibraries |
US5770367A (en) | 1993-07-30 | 1998-06-23 | Oxford Gene Technology Limited | Tag reagent and assay method |
US5770721A (en) | 1993-08-11 | 1998-06-23 | University Of Chicago | Method of manufacturing a matrix for the detection of mismatches |
US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
US5773222A (en) | 1992-05-27 | 1998-06-30 | National Blood Authority | Solid phase immunological assay |
US5776711A (en) | 1996-11-12 | 1998-07-07 | The Regents Of The University Of California | Simultaneous human ABO and RH(D) blood typing or antibody screening by flow cytometry |
US5779976A (en) | 1988-11-03 | 1998-07-14 | Igen International, Inc. | Apparatus for improved luminescence assays |
US5786219A (en) | 1996-10-28 | 1998-07-28 | Molecular Probes, Inc. | Microspheres with fluorescent spherical zones |
US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
US5792430A (en) | 1996-08-12 | 1998-08-11 | Monsanto Company | Solid phase organic synthesis device with pressure-regulated manifold |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5807755A (en) | 1987-08-06 | 1998-09-15 | Multilyte Limited | Determination of ambient concentrations of several analytes |
US5812272A (en) | 1997-01-30 | 1998-09-22 | Hewlett-Packard Company | Apparatus and method with tiled light source array for integrated assay sensing |
US5814524A (en) | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
US5831045A (en) | 1996-08-05 | 1998-11-03 | Porlinx, Incorporated | Boronic acid-containing polynucleotides |
US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
US5837501A (en) | 1993-07-09 | 1998-11-17 | Akzo Nobel N.V. | Nucleic acid quantitation by co-amplification of target with multiple internal controls |
US5837551A (en) | 1993-12-24 | 1998-11-17 | Ekins; Roger P. | Binding assay |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5840485A (en) | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
US5844304A (en) | 1994-09-30 | 1998-12-01 | Nec Corporation | Process for manufacturing semiconductor device and semiconductor wafer |
US5843660A (en) | 1994-09-30 | 1998-12-01 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
US5855753A (en) | 1996-11-26 | 1999-01-05 | The Trustees Of Princeton University | Method for electrohydrodynamically assembling patterned colloidal structures |
US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
US5866331A (en) | 1995-10-20 | 1999-02-02 | University Of Massachusetts | Single molecule detection by in situ hybridization |
US5876946A (en) | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US5898071A (en) | 1994-09-20 | 1999-04-27 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
US5939021A (en) | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
US5942388A (en) | 1994-02-22 | 1999-08-24 | Yissum Research Development Company Of The Hebrew University Of Jersaleum | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium, and electrodes thereof |
US5945525A (en) | 1995-07-07 | 1999-08-31 | Toyo Boseki Kabushiki Kaisha | Method for isolating nucleic acids using silica-coated magnetic particles |
US5948621A (en) | 1997-09-30 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Direct molecular patterning using a micro-stamp gel |
US5948627A (en) | 1997-05-30 | 1999-09-07 | One Lambda | Immunobead flow cytometric detection of anti-HLA panel-reactive antibody |
US5952131A (en) | 1998-04-27 | 1999-09-14 | Xerox Corporation | Core and shell matrix compositions and processes |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US5961923A (en) | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
US5965235A (en) | 1996-11-08 | 1999-10-12 | The Procter & Gamble Co. | Three-dimensional, amorphous-patterned, nesting-resistant sheet materials and method and apparatus for making same |
US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US5989835A (en) | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
US5988432A (en) | 1998-03-25 | 1999-11-23 | Sarnoff Corporation | Bead manipulating chucks with bead size selector |
US5993935A (en) | 1991-10-11 | 1999-11-30 | 3M Innovative Properties Company | Covalently reactive particles incorporated in a continous porous matrix |
US5994066A (en) | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
US6001614A (en) | 1998-07-24 | 1999-12-14 | Lumigen, Inc. | Methods of synthesizing labeled polynucleotides by ligation of multiple oligomers |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US6007996A (en) | 1995-12-12 | 1999-12-28 | Applied Spectral Imaging Ltd. | In situ method of analyzing cells |
US6013531A (en) | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
US6014451A (en) | 1997-10-17 | 2000-01-11 | Pioneer Hi-Bred International, Inc. | Remote imaging system for plant diagnosis |
US6015666A (en) | 1994-06-23 | 2000-01-18 | Bayer Aktiengesellschaft | Rapid DNA test for detecting quinolone-resistant Staphylococcus aureus pathogens in clinical material |
US6015664A (en) | 1995-11-03 | 2000-01-18 | Mcw Research Foundation | Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B |
US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US6018350A (en) | 1996-10-29 | 2000-01-25 | Real 3D, Inc. | Illumination and shadow simulation in a computer graphics/imaging system |
US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
US6023590A (en) | 1996-05-24 | 2000-02-08 | Asahi Kogaku Kogyo Kabushiki Kaisha | Image recording device |
US6025905A (en) | 1996-12-31 | 2000-02-15 | Cognex Corporation | System for obtaining a uniform illumination reflectance image during periodic structured illumination |
US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
US6027889A (en) | 1996-05-29 | 2000-02-22 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6043354A (en) | 1996-01-31 | 2000-03-28 | Invitek Gmbh | Method for the simultaneous isolation of genomic DNA and high-purity RNA |
US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US6060243A (en) | 1997-07-17 | 2000-05-09 | Procrea Biosciences Inc. | Primers for obtaining highly informative DNA markers |
US6063569A (en) | 1995-06-07 | 2000-05-16 | Perseptive Biosystems, Inc. | Methods for automated synthesis of PNA-DNA chimeras and compositions thereof |
US6068818A (en) | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
US6075905A (en) | 1996-07-17 | 2000-06-13 | Sarnoff Corporation | Method and apparatus for mosaic image construction |
US6077674A (en) | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
US6077669A (en) | 1997-11-04 | 2000-06-20 | Becton Dickinson And Company | Kit and method for fluorescence based detection assay |
US6080585A (en) | 1994-02-01 | 2000-06-27 | Oxford Gene Technology Limited | Methods for discovering ligands |
US6083699A (en) | 1996-05-01 | 2000-07-04 | Visible Genetics Inc. | Method for bi-directional sequencing of nucleic acid polymers |
US6084991A (en) | 1996-05-23 | 2000-07-04 | Agilent Technologies Inc. | CCD imager for confocal scanning microscopy |
US6083763A (en) | 1996-12-31 | 2000-07-04 | Genometrix Inc. | Multiplexed molecular analysis apparatus and method |
US6086736A (en) | 1996-08-02 | 2000-07-11 | Texas Tech University | Electromigration injection from a microreservoir-electrode in capillary separation systems |
US6090458A (en) | 1994-12-22 | 2000-07-18 | Nec Corporation | Method and apparatus for film formation by chemical vapor deposition |
US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
US6090545A (en) | 1995-03-10 | 2000-07-18 | Meso Scale Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US6090912A (en) | 1993-05-27 | 2000-07-18 | Selectide Corporation | Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond |
US6096368A (en) | 1998-02-19 | 2000-08-01 | Delsys Pharmaceutical Corporation | Bead transporter chucks using repulsive field guidance and method |
US6100030A (en) | 1997-01-10 | 2000-08-08 | Pioneer Hi-Bred International, Inc. | Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening |
US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
US6106685A (en) | 1997-05-13 | 2000-08-22 | Sarnoff Corporation | Electrode combinations for pumping fluids |
US6122599A (en) | 1998-02-13 | 2000-09-19 | Mehta; Shailesh | Apparatus and method for analyzing particles |
US6120666A (en) | 1996-09-26 | 2000-09-19 | Ut-Battelle, Llc | Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same |
US6124092A (en) | 1996-10-04 | 2000-09-26 | The Perkin-Elmer Corporation | Multiplex polynucleotide capture methods and compositions |
US6123263A (en) | 1998-01-29 | 2000-09-26 | Meta Holdings Corporation | Hand held dataform reader having strobing ultraviolet light illumination assembly for reading fluorescent dataforms |
US6126731A (en) | 1998-08-21 | 2000-10-03 | Idea Development Company | Polymerizable ink composition |
US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
US6132685A (en) | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
US6136171A (en) | 1998-09-18 | 2000-10-24 | The University Of Utah Research Foundation | Micromachined electrical field-flow fractionation system |
US6136468A (en) | 1998-08-25 | 2000-10-24 | Timer Technologies, Llc | Electrochemical cell with deferred assembly |
US6139831A (en) | 1998-05-28 | 2000-10-31 | The Rockfeller University | Apparatus and method for immobilizing molecules onto a substrate |
US6141046A (en) | 1994-10-25 | 2000-10-31 | Roth; Stephen Anthony | Electronic camera having an illuminator with dispersing ring lens |
US6143499A (en) | 1996-12-17 | 2000-11-07 | University Of Chicago | Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing |
US6151062A (en) | 1997-02-18 | 2000-11-21 | Canon Kabushiki Kaisha | Stereoscopic image display apparatus using specific mask pattern |
US6150095A (en) | 1995-04-07 | 2000-11-21 | Oxford Gene Technology Limited | Method for analyzing a polynucleotide containing a variable sequence |
US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
US6153375A (en) | 1994-11-18 | 2000-11-28 | Cambridge Combinatorial Limited | Method of making a library of compounds using a functionalized polymer support resin affixed to a laminar material |
US6153389A (en) | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6172218B1 (en) | 1994-10-13 | 2001-01-09 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US6180226B1 (en) | 1996-08-01 | 2001-01-30 | Loctite (R&D) Limited | Method of forming a monolayer of particles, and products formed thereby |
US6183970B1 (en) | 1998-08-27 | 2001-02-06 | Hitachi, Ltd. | Polynucleotide probe chip and polynucleotide detection method |
US6187540B1 (en) | 1998-11-09 | 2001-02-13 | Identigene, Inc. | Method of newborn identification and tracking |
US6193951B1 (en) | 1997-04-30 | 2001-02-27 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents |
US6193866B1 (en) | 1996-03-27 | 2001-02-27 | Curagen Corporation | Separation of charged particles by a spatially and temporally varying electric field |
US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
US6200737B1 (en) | 1995-08-24 | 2001-03-13 | Trustees Of Tufts College | Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure |
US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US6209589B1 (en) | 1996-10-21 | 2001-04-03 | Smithkline Beecham Plc | Apparatus and method for distributing beads |
US6221598B1 (en) | 1994-09-30 | 2001-04-24 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6238863B1 (en) | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
US6245508B1 (en) | 1993-11-01 | 2001-06-12 | Nanogen, Inc. | Method for fingerprinting utilizing an electronically addressable array |
US6251687B1 (en) | 1993-09-24 | 2001-06-26 | Biosite Diagnostics, Inc. | Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds |
US6251691B1 (en) | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
US6251595B1 (en) | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
US6251592B1 (en) | 1998-05-26 | 2001-06-26 | Procrea Biosciences Inc. | STR marker system for DNA fingerprinting |
US6254827B1 (en) | 1993-11-01 | 2001-07-03 | Nanogen, Inc. | Methods for fabricating multi-component devices for molecular biological analysis and diagnostics |
US6254754B1 (en) | 1998-07-29 | 2001-07-03 | Agilent Technologies, Inc. | Chip for performing an electrophoretic separation of molecules and method using same |
US6261430B1 (en) | 1995-06-08 | 2001-07-17 | Visible Genetics Inc. | Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules |
US6261782B1 (en) | 1999-04-06 | 2001-07-17 | Yale University | Fixed address analysis of sequence tags |
US6264825B1 (en) | 1998-06-23 | 2001-07-24 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
US6264815B1 (en) | 1996-07-26 | 2001-07-24 | Btg International Limited | Apparatus and method for testing using dielectrophoresis |
US6268222B1 (en) | 1998-01-22 | 2001-07-31 | Luminex Corporation | Microparticles attached to nanoparticles labeled with flourescent dye |
US6268219B1 (en) | 1999-07-09 | 2001-07-31 | Orchid Biosciences, Inc. | Method and apparatus for distributing fluid in a microfluidic device |
US6267858B1 (en) | 1996-06-28 | 2001-07-31 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6271856B1 (en) | 1998-11-19 | 2001-08-07 | Paraform, Inc. | Creating and modifying parameterizations of surfaces |
US6277579B1 (en) | 1998-02-06 | 2001-08-21 | Digene Corporation | Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function |
US6280618B2 (en) | 1997-11-18 | 2001-08-28 | Bio-Rad Laboratories, Inc. | Multiplex flow assays preferably with magnetic particles as solid phase |
US6287778B1 (en) | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6297062B1 (en) | 1996-03-07 | 2001-10-02 | Bio-Magnetics Ltd. | Separation by magnetic particles |
US6303316B1 (en) | 1999-07-02 | 2001-10-16 | Conceptual Mind Works, Inc. | Organic semiconductor recognition complex and system |
US6306643B1 (en) | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
US20010034614A1 (en) | 2000-03-01 | 2001-10-25 | Peter Fletcher-Haynes | Extracorporeal blood processing information management system |
US6309602B1 (en) | 1993-11-01 | 2001-10-30 | Nanogen, Inc. | Stacked, reconfigurable system for electrophoretic transport of charged materials |
US6312134B1 (en) | 1996-07-25 | 2001-11-06 | Anvik Corporation | Seamless, maskless lithography system using spatial light modulator |
US6316186B1 (en) | 1994-03-11 | 2001-11-13 | Multilyte Limited | Binding assay using binding agents with tail groups |
US6318970B1 (en) | 1998-03-12 | 2001-11-20 | Micralyne Inc. | Fluidic devices |
US6319472B1 (en) | 1993-11-01 | 2001-11-20 | Nanogen, Inc. | System including functionally separated regions in electrophoretic system |
US6319674B1 (en) | 1999-09-16 | 2001-11-20 | Agilent Technologies, Inc. | Methods for attaching substances to surfaces |
US20010044531A1 (en) | 1998-07-31 | 2001-11-22 | Mcgall Glenn | Nucleic acid labeling compounds |
US20010046602A1 (en) | 2000-04-06 | 2001-11-29 | Chandler Don J. | Magnetically-responsive microspheres |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
US20010049095A1 (en) | 1998-06-01 | 2001-12-06 | Teresa A. Webster | Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions |
US20020006634A1 (en) | 1999-05-11 | 2002-01-17 | Han In Suk | Methods and compositions for use of catalase in hydrogels and biosensors |
US6342355B1 (en) | 1997-11-26 | 2002-01-29 | The United States Of America As Represented By The Department Of Health & Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
US20020015952A1 (en) | 1999-07-30 | 2002-02-07 | Anderson Norman G. | Microarrays and their manufacture by slicing |
US6349144B1 (en) | 1998-02-07 | 2002-02-19 | Biodiscovery, Inc. | Automated DNA array segmentation and analysis |
US20020022276A1 (en) | 1999-03-15 | 2002-02-21 | Yuxiang Zhou | Individually addressable micro-electromagnetic unit array chips |
US20020029235A1 (en) | 2000-05-11 | 2002-03-07 | Becton Dickinson And Company | System for identifying clusters in scatter plots using smoothed polygons with optimal boundaries |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US6355419B1 (en) | 1998-04-27 | 2002-03-12 | Hyseq, Inc. | Preparation of pools of nucleic acids based on representation in a sample |
US20020031841A1 (en) | 1996-11-06 | 2002-03-14 | Asher Sanford A. | Colorimetric reagent |
US20020032252A1 (en) | 2000-07-06 | 2002-03-14 | Takahiro Ishizuka | Colored particulate dispersion, ink for ink-jet recording using the same, and ink-jet recording method |
US6358387B1 (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods |
US6361916B1 (en) | 1999-12-14 | 2002-03-26 | Eastman Kodak Company | Loaded latex compositions with dye and stabilizer |
US6361945B1 (en) | 1998-07-02 | 2002-03-26 | Gen-Probe Incorporated | Molecular torches |
US6365418B1 (en) | 1998-07-14 | 2002-04-02 | Zyomyx, Incorporated | Arrays of protein-capture agents and methods of use thereof |
US20020039728A1 (en) | 2000-02-10 | 2002-04-04 | Robert Kain | Alternative substrates and formats for bead-based array of arrays |
US6368799B1 (en) | 1997-06-13 | 2002-04-09 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
US20020045169A1 (en) | 2000-08-25 | 2002-04-18 | Shoemaker Daniel D. | Gene discovery using microarrays |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US6399328B1 (en) | 1997-03-21 | 2002-06-04 | Musc Foundation For Research Development | Methods and compositions for diagnosis and treatment of breast cancer |
US6403309B1 (en) | 1999-03-19 | 2002-06-11 | Valigen (Us), Inc. | Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays |
US20020081714A1 (en) | 2000-05-05 | 2002-06-27 | Maneesh Jain | Devices and methods to form a randomly ordered array of magnetic beads and uses thereof |
US20020102567A1 (en) | 1989-06-07 | 2002-08-01 | Fodor Stephen P.A. | Method for comparing nucleic acid sequences |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
US6448012B1 (en) | 1988-09-15 | 2002-09-10 | Wisconsin Alumni Research Foundation | Method for mapping a nucleic acid |
US20020127603A1 (en) | 2000-10-12 | 2002-09-12 | Amnis Corporation | Methods for synthesizing reporter labeled beads |
US20020125138A1 (en) | 1999-05-18 | 2002-09-12 | Gianni Medoro | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
US6451191B1 (en) | 1999-11-18 | 2002-09-17 | 3M Innovative Properties Company | Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same |
US20020137074A1 (en) | 2000-11-21 | 2002-09-26 | Piunno Paul A.E. | Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry |
US6458547B1 (en) | 1996-12-12 | 2002-10-01 | Prolume, Ltd. | Apparatus and method for detecting and identifying infectious agents |
US20020142318A1 (en) | 2001-03-30 | 2002-10-03 | Cattell Herbert F. | Chemical array reading |
US20020150909A1 (en) | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
US20020155481A1 (en) | 2001-02-08 | 2002-10-24 | Ngk Insulators, Ltd. | Biochip and method for producing the same |
US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
US20020166766A1 (en) | 2001-03-21 | 2002-11-14 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US6488872B1 (en) | 1999-07-23 | 2002-12-03 | The Board Of Trustees Of The University Of Illinois | Microfabricated devices and method of manufacturing the same |
US20020182609A1 (en) | 2000-08-16 | 2002-12-05 | Luminex Corporation | Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping |
US20020187501A1 (en) | 2001-01-26 | 2002-12-12 | Mingxian Huang | Microdevices having a preferential axis of magnetization and uses thereof |
US6494924B1 (en) | 1998-04-03 | 2002-12-17 | Basf Aktiengesellschaft | Precipitated water-insoluble colorants in colloid disperse form |
US6498863B1 (en) | 2000-09-20 | 2002-12-24 | Media Cybernetics Inc. | Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay |
US20020198665A1 (en) | 2000-09-17 | 2002-12-26 | Michael Seul | System and method for programmable illumination pattern generation |
US20020197728A1 (en) | 1999-12-15 | 2002-12-26 | Howard Kaufman | Methods of monitoring effects of chemical agents on a sample |
US6500620B2 (en) | 1999-12-29 | 2002-12-31 | Mergen Ltd. | Methods for amplifying and detecting multiple polynucleotides on a solid phase support |
US20030004594A1 (en) | 2000-02-02 | 2003-01-02 | Liu Vincent Bardina | Flexible manufacturing system |
US20030003272A1 (en) | 2001-06-21 | 2003-01-02 | Bruno Laguitton | Polyanion/polycation multilayer film for DNA immobilization |
US6503680B1 (en) | 2001-08-29 | 2003-01-07 | Xerox Corporation | Latex processes |
US20030006143A1 (en) | 2001-06-21 | 2003-01-09 | Sukanta Banerjee | Directed assembly of functional heterostructures |
US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US20030012699A1 (en) | 1998-11-18 | 2003-01-16 | Thomas Moore | Simultaneous handling of magnetic beads in a two-dimensional arrangement |
US20030012693A1 (en) | 2000-08-24 | 2003-01-16 | Imego Ab | Systems and methods for localizing and analyzing samples on a bio-sensor chip |
US6509158B1 (en) | 1988-09-15 | 2003-01-21 | Wisconsin Alumni Research Foundation | Image processing and analysis of individual nucleic acid molecules |
US20030022370A1 (en) | 2001-07-27 | 2003-01-30 | Rocco Casagrande | Magnetic immobilization of cells |
US6515649B1 (en) | 1995-07-20 | 2003-02-04 | E Ink Corporation | Suspended particle displays and materials for making the same |
US6514688B2 (en) | 1995-07-31 | 2003-02-04 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Separating, detecting or quantifying biological materials using magnetic cross-linked polyvinyl alcohol particles |
US20030031351A1 (en) | 2000-02-11 | 2003-02-13 | Yim Peter J. | Vessel delineation in magnetic resonance angiographic images |
US6521747B2 (en) | 2000-08-28 | 2003-02-18 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the AGTR1 gene |
US20030040129A1 (en) | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
US20030038812A1 (en) | 2000-10-24 | 2003-02-27 | Affymetrix, Inc. A Corporation Organized Under The Laws Of Delaware | Computer software system, method, and product for scanned image alignment |
US6528264B1 (en) | 2000-11-01 | 2003-03-04 | Corning Incorporated | Polymer support for DNA immobilization |
US6531292B1 (en) | 1995-08-17 | 2003-03-11 | The Regents Of The University Of California | Genes and proteins controlling cholesterol synthesis |
US6531323B1 (en) | 1999-01-28 | 2003-03-11 | Fuji Photo Film Co., Ltd. | Agglutination assay method and element in a dry system |
US6534293B1 (en) | 1999-01-06 | 2003-03-18 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US20030062422A1 (en) | 2001-09-10 | 2003-04-03 | Fateley William G. | System and method for encoded spatio-spectral information processing |
US20030077607A1 (en) | 2001-03-10 | 2003-04-24 | Hopfinger Anton J. | Methods and tools for nucleic acid sequence analysis, selection, and generation |
US20030082587A1 (en) | 2001-12-28 | 2003-05-01 | Michael Seul | Arrays of microparticles and methods of preparation thereof |
US20030082531A1 (en) | 1990-02-16 | 2003-05-01 | Hans E. Soderlund | Method and reagent for determining specific nucleotide variations |
US20030082487A1 (en) | 2001-10-29 | 2003-05-01 | Robert Burgess | Three dimensional printing using photo-activated building materials |
US20030087228A1 (en) | 1998-05-06 | 2003-05-08 | Cynthia Bamdad | Electronic detection of nucleic acids using monolayers |
US20030108913A1 (en) | 2000-02-15 | 2003-06-12 | Schouten Johannes Petrus | Multiplex ligatable probe amplification |
US20030129296A1 (en) | 2001-07-17 | 2003-07-10 | David Kelso | Film-immobilized capture particles |
US20030134326A1 (en) | 2001-12-21 | 2003-07-17 | Hansen Mark R. | Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences |
US20030148335A1 (en) | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
US6605474B1 (en) | 1998-02-24 | 2003-08-12 | Genevac Limited | Method and apparatus for determining temperature of and controlling the evaporation of liquid samples |
US6605453B2 (en) | 1999-12-01 | 2003-08-12 | The Regents Of The University Of California | Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells |
US20030152931A1 (en) | 2002-02-11 | 2003-08-14 | Chung-Fan Chiou | Nucleic acid detection device and method utilizing the same |
US20030154108A1 (en) | 2000-03-01 | 2003-08-14 | Gambro, Inc. | Extracorporeal blood processing information management system |
US6610256B2 (en) | 1989-04-05 | 2003-08-26 | Wisconsin Alumni Research Foundation | Image processing and analysis of individual nucleic acid molecules |
US6620584B1 (en) | 1999-05-20 | 2003-09-16 | Illumina | Combinatorial decoding of random nucleic acid arrays |
US20030177036A1 (en) | 2002-03-12 | 2003-09-18 | Colin Corporation | Statistical-medical-information supplying method and apparatus |
US20030182068A1 (en) | 2001-10-30 | 2003-09-25 | Battersby Bronwyn J. | Device and methods for directed synthesis of chemical libraries |
US20030186220A1 (en) | 2002-03-28 | 2003-10-02 | Jizhong Zhou | Detecting microorganisms using whole genomic DNA or RNA microarray |
US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
US6645432B1 (en) | 2000-05-25 | 2003-11-11 | President & Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
US6650703B1 (en) | 1996-08-23 | 2003-11-18 | Deutsche Telekom Ag | Picture-transmitting remote object inspection system |
US20030228610A1 (en) | 1996-04-25 | 2003-12-11 | Michael Seul | Encoded beads having oligonucleotides attached and formed in arrays |
US6670128B2 (en) | 2000-08-16 | 2003-12-30 | Whatman, Inc. | Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies |
US20040002073A1 (en) | 2001-10-15 | 2004-01-01 | Li Alice Xiang | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US20040009614A1 (en) | 2000-05-12 | 2004-01-15 | Ahn Chong H | Magnetic bead-based arrays |
US20040014073A1 (en) | 2000-08-08 | 2004-01-22 | Dieter Trau | Capsules encapsulating solid particles of signal-generating organic substances and their use in vitro bioassays for detection of target molecules in a sample |
US6692914B1 (en) | 1999-07-02 | 2004-02-17 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
US6703288B2 (en) | 2001-05-10 | 2004-03-09 | Hoya Corporation | Compound crystal and method of manufacturing same |
US20040048259A1 (en) | 2002-09-09 | 2004-03-11 | Ghazala Hashmi | Genetic analysis and authentication |
US6713309B1 (en) | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
US6730515B2 (en) | 2002-06-11 | 2004-05-04 | Eastman Kodak Company | Micro-array calibration means |
US20040087032A1 (en) * | 1999-08-17 | 2004-05-06 | Chandler Mark B. | Microparticles with multiple fluorescent signals and methods of using same |
US20040093238A1 (en) | 2002-11-08 | 2004-05-13 | Deakter Daniel R. | System and process for matching patients with clinical medical trials |
US6743581B1 (en) | 1999-01-25 | 2004-06-01 | Ut-Battelle, Lc | Multifunctional and multispectral biosensor devices and methods of use |
US20040106121A1 (en) | 2000-11-29 | 2004-06-03 | Commissariat A L'energie Atomique | Static micro-array of biological or chemical probes immobilised on a support by magnetic attraction |
US6760157B1 (en) | 1996-02-29 | 2004-07-06 | 3M Innovative Properties Company | Brightness enhancement film |
US20040132122A1 (en) | 2000-06-21 | 2004-07-08 | Sukanta Banerjee | Multianalyte molecular analysis using application-specific random particle arrays |
US20040137641A1 (en) | 2001-04-24 | 2004-07-15 | Jostein Holtlund | Haemoglobin assay |
US6779559B2 (en) | 2001-01-29 | 2004-08-24 | Caliper Life Sciences, Inc. | Non-mechanical valves for fluidic systems |
US20040175734A1 (en) | 1998-08-28 | 2004-09-09 | Febit Ferrarius Biotechnology Gmbh | Support for analyte determination methods and method for producing the support |
US6812005B2 (en) | 2000-02-07 | 2004-11-02 | The Regents Of The University Of California | Nucleic acid detection methods using universal priming |
US20040229269A1 (en) | 2003-05-15 | 2004-11-18 | Ghazala Hashmi | Hybridization-mediated analysis of polymorphisms |
US6824981B2 (en) * | 2000-08-11 | 2004-11-30 | Agilix Corporation | Ultra-sensitive detection systems using alterable peptide tags |
US6838289B2 (en) | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US6844156B2 (en) | 1999-10-19 | 2005-01-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods for identifying a preferred liver transplant donor |
US20050048570A1 (en) | 2001-12-28 | 2005-03-03 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten | Structured-functional bonding matrices for biomolecules |
US6869798B2 (en) | 2003-04-17 | 2005-03-22 | Clinical Diagnostics Solutions, Inc. | Lytic reagent composition for leukocyte differential analysis |
US6890741B2 (en) | 2000-02-07 | 2005-05-10 | Illumina, Inc. | Multiplexed detection of analytes |
US6897271B1 (en) | 2000-01-05 | 2005-05-24 | Novartis Ag | Porous hydrogels |
US20050112585A1 (en) | 2003-11-21 | 2005-05-26 | Dominic Zichi | Method for adjusting the quantification range of individual analytes in a multiplexed assay |
US6905881B2 (en) | 2000-11-30 | 2005-06-14 | Paul Sammak | Microbead-based test plates and test methods for fluorescence imaging systems |
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US20050143928A1 (en) | 2003-10-03 | 2005-06-30 | Cira Discovery Sciences, Inc. | Method and apparatus for discovering patterns in binary or categorical data |
US6942968B1 (en) | 1999-08-30 | 2005-09-13 | Illumina, Inc. | Array compositions for improved signal detection |
US6955902B2 (en) | 1998-04-10 | 2005-10-18 | Serono Genetics Institute, Inc. | High throughput DNA sequencing vector |
US6955889B1 (en) | 1999-06-08 | 2005-10-18 | Ortho-Clinical Diagnostics, Inc. | Simultaneous determination of forward and reverse ABO blood group |
US6958245B2 (en) | 1996-04-25 | 2005-10-25 | Bioarray Solutions Ltd. | Array cytometry |
US20050239098A1 (en) | 1998-12-23 | 2005-10-27 | Human Genome Sciences, Inc. | Novel hyaluronan-binding proteins and encoding genes |
US6993156B1 (en) | 2000-02-18 | 2006-01-31 | Microsoft Corporation | System and method for statistically comparing and matching plural sets of digital data |
US20060035240A1 (en) | 2003-10-28 | 2006-02-16 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
US7041453B2 (en) | 2002-08-22 | 2006-05-09 | Bioarray Solutions Ltd. | Molecular constructs and methods of use for detection of biochemical reactions |
US7049077B2 (en) | 2003-10-29 | 2006-05-23 | Bioarray Solutions Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA |
US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
US7099777B1 (en) | 1997-09-05 | 2006-08-29 | Affymetrix, Inc. | Techniques for identifying confirming mapping and categorizing nucleic acids |
US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US7132239B2 (en) | 1998-02-04 | 2006-11-07 | Applera Corporation | Determination of a genotype of an amplification product at multiple allelic sites |
US7141217B2 (en) | 2002-12-05 | 2006-11-28 | Uop Llc | Elevated pressure apparatus and method for generating a plurality of isolated effluents |
US7144119B2 (en) | 1996-04-25 | 2006-12-05 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US20060275799A1 (en) | 2005-06-01 | 2006-12-07 | Sukanta Banerjee | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US7195913B2 (en) | 2001-10-05 | 2007-03-27 | Surmodics, Inc. | Randomly ordered arrays and methods of making and using |
US7229840B1 (en) | 2000-11-02 | 2007-06-12 | Andreas Hofmann | Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels |
US20070231810A1 (en) | 2005-10-07 | 2007-10-04 | Todd Alison V | Multicomponent nucleic acid enzymes and methods for their use |
US20070243534A1 (en) | 2006-04-12 | 2007-10-18 | Michael Seul | Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase |
US20080020374A1 (en) | 2004-02-20 | 2008-01-24 | Greene Mark I | Reagents, Kits and Methods for Immunodetection of Epitopes on Molecules |
US7358097B2 (en) | 1996-04-25 | 2008-04-15 | Bio Array Solutions Ltd. | Making a matrix of random encoded arrays |
US20080261205A1 (en) | 2004-02-06 | 2008-10-23 | Canadian Blood Services | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes |
US7501253B2 (en) | 2004-09-21 | 2009-03-10 | The Board Of Trustees Of The Leland Stanford Junior University | DNA fingerprinting using a branch migration assay |
US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
US7582488B2 (en) | 2003-10-28 | 2009-09-01 | Bio Array Solutions Ltd. | Gel-shell beads with adsorbed or bound biomolecules |
US7595279B2 (en) | 2003-09-22 | 2009-09-29 | Bioarray Solutions Ltd. | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
WO2010026038A1 (en) | 2008-09-02 | 2010-03-11 | Siemens Aktiengesellschaft | Busbar and busbar system in flat profile design comprising a plurality of partial conductor rails having recesses at the narrow side for latching of contact spring elements |
US20100062518A1 (en) | 2008-09-09 | 2010-03-11 | Sukanta Banerjee | Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample |
WO2010098765A1 (en) | 2009-02-27 | 2010-09-02 | Leslie Cifuentes French | Dispenser and applicator that bring reactive substances into contact with each other at the time of use |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
EP1564306B1 (en) | 2004-02-17 | 2013-08-07 | Affymetrix, Inc. | Methods for fragmenting and labeling DNA |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999036564A1 (en) | 1998-01-16 | 1999-07-22 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
MXPA02003284A (en) | 1999-10-01 | 2002-10-04 | Surromed Inc | Method of manufacture of colloidal rod particles as nanobar codes. |
US7225082B1 (en) | 1999-10-01 | 2007-05-29 | Oxonica, Inc. | Colloidal rod particles as nanobar codes |
EP1379693B1 (en) | 2001-03-28 | 2009-05-20 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified particles |
-
2004
- 2004-09-17 WO PCT/US2004/030499 patent/WO2005029705A2/en active Application Filing
- 2004-09-17 US US10/943,760 patent/US7927796B2/en not_active Expired - Fee Related
-
2011
- 2011-03-24 US US13/071,055 patent/US8615367B2/en not_active Expired - Fee Related
Patent Citations (559)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4575407A (en) | 1962-12-03 | 1986-03-11 | Diller Isaac M | Product and process for the activation of an electrolytic cell |
US3329638A (en) | 1963-09-05 | 1967-07-04 | Monsanto Co | Multilayered polymeric latices with hydrophilic surface layer |
US3574614A (en) | 1967-01-06 | 1971-04-13 | Xerox Corp | Process of preparing multiple copies from a xeroprinting master |
US3989775A (en) | 1971-03-01 | 1976-11-02 | Bakelite Xylonite Limited | Method of making a retro-reflective beaded material |
US3790492A (en) | 1971-03-11 | 1974-02-05 | Atomic Energy Commission | Method for production of uniform microspheres |
US3982182A (en) | 1973-08-13 | 1976-09-21 | Coulter Electronics, Inc. | Conductivity cell for particle study device |
US3998525A (en) | 1973-10-26 | 1976-12-21 | American Cyanamid Company | Edge lighted electrochromic displays |
US3957741A (en) | 1974-01-17 | 1976-05-18 | California Institute Of Technology | Crosslinked, porous, polyacrylate beads |
US4199363A (en) | 1974-09-17 | 1980-04-22 | Eastman Kodak Company | Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions |
US4055799A (en) | 1975-01-23 | 1977-10-25 | Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung | Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells |
US4140937A (en) | 1975-07-22 | 1979-02-20 | Aron Vecht | Direct current electroluminescent devices |
US4003713A (en) | 1975-08-14 | 1977-01-18 | Bowser Everett N | Multiple test tube evaporator |
US4275053A (en) | 1975-08-14 | 1981-06-23 | Mt. Sinai School Of Medicine Of The City University Of New York | Blood cell typing and compatibility test procedure |
US4046667A (en) | 1975-10-30 | 1977-09-06 | Pen Kem, Inc. | Microelectrophoresis apparatus |
US4143203A (en) | 1976-03-19 | 1979-03-06 | Amicon Corporation | Particulate support material |
US4326008A (en) | 1976-08-27 | 1982-04-20 | California Institute Of Technology | Protein specific fluorescent microspheres for labelling a protein |
US4075013A (en) | 1976-09-13 | 1978-02-21 | Ward Anthony T | Electrophotochemical preparation of selenium photoconductive members |
US4102990A (en) | 1977-12-05 | 1978-07-25 | General Electric Company | Electrophoretic assay for antigen-antibody reaction based on particle-particle coupling |
US4336173A (en) | 1978-02-21 | 1982-06-22 | Sintef | Process for preparing an aqueous emulsion or dispersion of a partly water-soluble material, and optionally further conversion of the prepared dispersion or emulsion to a polymer dispersion when the partly water-soluble material is a polymerizable monomer |
US4459378A (en) | 1978-02-21 | 1984-07-10 | Sintef | Monodisperse polymer particles and dispersions thereof |
US4258001A (en) | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
US4267235A (en) | 1979-03-19 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde microspheres |
US4339337A (en) | 1979-08-24 | 1982-07-13 | Rhone-Poulenc Industries | Process for the preparation of magnetic beads of vinylaromatic polymers |
US4421896A (en) | 1979-11-13 | 1983-12-20 | The Dow Chemical Company | Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products formed therefrom |
US4806776A (en) | 1980-03-10 | 1989-02-21 | Kley Victor B | Electrical illumination and detecting apparatus |
US4358388A (en) | 1980-04-18 | 1982-11-09 | Rhone Poulenc Industries | Magnetic polymer latex and preparation process |
US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4829101A (en) | 1981-04-29 | 1989-05-09 | Rohm Gmbh | Polymer particles and latices thereof for the immobilization of biologically active substances |
US4456513A (en) | 1981-09-10 | 1984-06-26 | Yoshio Kawai | Method of and apparatus for measuring electrophoretic mobility |
US4774265A (en) | 1982-04-23 | 1988-09-27 | Sintef | Process for preparing magnetic polymer particles |
US4654267A (en) | 1982-04-23 | 1987-03-31 | Sintef | Magnetic polymer particles and process for the preparation thereof |
US4499052A (en) | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
US4717655A (en) | 1982-08-30 | 1988-01-05 | Becton, Dickinson And Company | Method and apparatus for distinguishing multiple subpopulations of cells |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4487855A (en) | 1983-02-15 | 1984-12-11 | Shih Yen Jer | Colored latexes; methods for making same and colored finely divided products |
US4824941A (en) | 1983-03-10 | 1989-04-25 | Julian Gordon | Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems |
US4672040A (en) | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
EP0126450B1 (en) | 1983-05-19 | 1992-09-09 | Ioannis Dr. Tripatzis | Particle and method for the detection of antigens and/or antibodies using this particle |
CA1248873A (en) | 1983-05-19 | 1989-01-17 | Ioannis Tripatzis | Particles and procedures for the determination of antigens and/or antibodies using the particles |
US4497208A (en) | 1983-06-23 | 1985-02-05 | Matec, Inc. | Measurement of electro-kinetic properties of a solution |
US4591550A (en) | 1984-03-01 | 1986-05-27 | Molecular Devices Corporation | Device having photoresponsive electrode for determining analytes including ligands and antibodies |
US4665020A (en) | 1984-05-30 | 1987-05-12 | United States Department Of Energy | Flow cytometer measurement of binding assays |
US4647544A (en) | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
US4774189A (en) | 1984-12-24 | 1988-09-27 | Flow Cytometry Standards Corp. | Fluorescent calibration microbeads simulating stained cells |
US5073498A (en) | 1984-12-24 | 1991-12-17 | Caribbean Microparticles Corporation | Fluorescent alignment microbeads with broad excitation and emission spectra and its use |
US4702598A (en) | 1985-02-25 | 1987-10-27 | Research Corporation | Flow cytometer |
US4613559A (en) | 1985-04-01 | 1986-09-23 | Xerox Corporation | Process for colored toner compositions with controlled charges thereon |
US5480723A (en) | 1985-04-08 | 1996-01-02 | Optical Sensors Incorporated | Surface-bound fluorescent polymers and related methods of synthesis and use |
US5700897A (en) | 1985-04-08 | 1997-12-23 | Optical Sensors Incorporated | Method for making fluorescent polymers |
US4753775A (en) | 1985-04-12 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Rapid assay processor |
US4806313A (en) | 1985-04-12 | 1989-02-21 | E. I. Du Pont De Nemours And Company | Rapid assay processor |
US4602989A (en) | 1985-09-17 | 1986-07-29 | Dorr-Oliver Incorporated | Method and apparatus for determining the zeta potential of colloidal particles |
US4679439A (en) | 1985-09-17 | 1987-07-14 | Dorr-Oliver Incorporated | Method and apparatus for measuring the unsteady sedimentation potential of colloidal particles |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5866099A (en) | 1985-10-04 | 1999-02-02 | Nycomed Imaging As | Magnetic-polymer particles |
US4663408A (en) | 1985-12-30 | 1987-05-05 | Exxon Research And Engineering Company | Tetrapolymers of N-vinyl pyrrolidone/acrylamide/salt of acrylic acid/N-alkyl acrylamide |
US4680332A (en) | 1986-01-24 | 1987-07-14 | Xerox Corporation | Ink jet compositions and process for preparation thereof |
US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
US5252494A (en) | 1986-06-25 | 1993-10-12 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix |
US4822746A (en) | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
US5254477A (en) | 1986-06-25 | 1993-10-19 | Trustees Of Tufts College | Flourescence intramolecular energy transfer conjugate compositions and detection methods |
US5114864A (en) | 1986-06-25 | 1992-05-19 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations |
US5143853A (en) | 1986-06-25 | 1992-09-01 | Trustees Of Tufts College | Absorbance modulated fluorescence detection methods and sensors |
US5306618A (en) | 1986-07-02 | 1994-04-26 | E. I. Du Pont De Nemours And Company | Method systems and reagents for DNA sequencing |
US4791310A (en) | 1986-10-02 | 1988-12-13 | Syracuse University | Fluorescence microscopy |
US5015452A (en) | 1986-11-17 | 1991-05-14 | Clarkson University | Process for synthesis of uniform colloidal particles of rare earth oxides |
US4891324A (en) | 1987-01-07 | 1990-01-02 | Syntex (U.S.A.) Inc. | Particle with luminescer for assays |
US5132097A (en) | 1987-02-11 | 1992-07-21 | G.D. Research | Apparatus for analysis of specific binding complexes |
US4911806A (en) | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
US5155044A (en) | 1987-03-13 | 1992-10-13 | Coulter Electronics, Inc. | Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples |
US5241012A (en) | 1987-05-19 | 1993-08-31 | Applied Immune Sciences, Inc. | Activated and conjugated polystyrene substrate |
US5389549A (en) | 1987-05-29 | 1995-02-14 | Toa Medical Electronics Co., Ltd. | Method for classifying leukocytes and a reagent used therefor |
US5028545A (en) | 1987-06-16 | 1991-07-02 | Wallac Oy | Biospecific multianalyte assay method |
US5132242A (en) | 1987-07-15 | 1992-07-21 | Cheung Sau W | Fluorescent microspheres and methods of using them |
US5194300A (en) | 1987-07-15 | 1993-03-16 | Cheung Sau W | Methods of making fluorescent microspheres |
US5807755A (en) | 1987-08-06 | 1998-09-15 | Multilyte Limited | Determination of ambient concentrations of several analytes |
US6013531A (en) | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
US5283079A (en) | 1987-10-26 | 1994-02-01 | Baxter Diagnostics Inc. | Process to make magnetically responsive fluorescent polymer particles |
US5395688A (en) | 1987-10-26 | 1995-03-07 | Baxter Diagnostics Inc. | Magnetically responsive fluorescent polymer particles |
US5091206A (en) | 1987-10-26 | 1992-02-25 | Baxter Diagnostics Inc. | Process for producing magnetically responsive polymer particles and application thereof |
US4832814A (en) | 1987-12-28 | 1989-05-23 | E. I. Du Pont De Nemours And Company | Electrofusion cell and method of making the same |
US4996265A (en) | 1988-01-29 | 1991-02-26 | Mita Industrial Co., Ltd. | Process for preparation of monodisperse polymer particles having increased particle size |
US4920056A (en) | 1988-02-19 | 1990-04-24 | The Dow Chemical Company | Apparatus and method for automated microbatch reaction |
US4873102A (en) | 1988-03-14 | 1989-10-10 | Manchium Chang | Magnetic particles |
US5244630A (en) | 1988-04-22 | 1993-09-14 | Abbott Laboratories | Device for performing solid-phase diagnostic assay |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US5185066A (en) | 1988-08-11 | 1993-02-09 | Helena Laboratories Corporation | Immunofixation electrophoresis control system |
US5173159A (en) | 1988-09-06 | 1992-12-22 | Bertin & Cie | Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates |
US6448012B1 (en) | 1988-09-15 | 2002-09-10 | Wisconsin Alumni Research Foundation | Method for mapping a nucleic acid |
US6509158B1 (en) | 1988-09-15 | 2003-01-21 | Wisconsin Alumni Research Foundation | Image processing and analysis of individual nucleic acid molecules |
US5436327A (en) | 1988-09-21 | 1995-07-25 | Isis Innovation Limited | Support-bound oligonucleotides |
US5266427A (en) | 1988-10-18 | 1993-11-30 | Nippondenso Co., Ltd. | Display board and method for producing the same |
US5779976A (en) | 1988-11-03 | 1998-07-14 | Igen International, Inc. | Apparatus for improved luminescence assays |
US5405784A (en) | 1988-11-04 | 1995-04-11 | Chemunex | Agglutination method for the determination of multiple ligands |
US5512439A (en) | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
US5536648A (en) | 1988-12-09 | 1996-07-16 | Amrad Corporation Limited | Amplified DNA assay using a double stranded DNA binding protein |
US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
US5356713A (en) | 1989-03-31 | 1994-10-18 | Rhone-Poulenc Chimie | Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology |
US6610256B2 (en) | 1989-04-05 | 2003-08-26 | Wisconsin Alumni Research Foundation | Image processing and analysis of individual nucleic acid molecules |
US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
US5510270A (en) | 1989-06-07 | 1996-04-23 | Affymax Technologies N.V. | Synthesis and screening of immobilized oligonucleotide arrays |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5744305A (en) | 1989-06-07 | 1998-04-28 | Affymetrix, Inc. | Arrays of materials attached to a substrate |
US20020102567A1 (en) | 1989-06-07 | 2002-08-01 | Fodor Stephen P.A. | Method for comparing nucleic acid sequences |
US5698271A (en) | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
US5362653A (en) | 1989-09-12 | 1994-11-08 | Carr Robert J G | Examination of objects of macromolecular size |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US5736349A (en) | 1989-09-29 | 1998-04-07 | Nippon Paint Co., Ltd. | Magnetic particle and immunoassay using the same |
US5194393A (en) | 1989-11-21 | 1993-03-16 | Bayar Aktiengesellschaft | Optical biosensor and method of use |
US5523231A (en) | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
US20030082530A1 (en) | 1990-02-16 | 2003-05-01 | Hans E. Soderlund | Reagent Kit for Determining Specific Nucleotide Variations |
US20030082531A1 (en) | 1990-02-16 | 2003-05-01 | Hans E. Soderlund | Method and reagent for determining specific nucleotide variations |
US5444330A (en) | 1990-02-26 | 1995-08-22 | Molecular Displays, Inc. | Electrochromic, electroluminescent and electrochemiluminescent displays |
US5126239A (en) | 1990-03-14 | 1992-06-30 | E. I. Du Pont De Nemours And Company | Process for detecting polymorphisms on the basis of nucleotide differences |
US5723218A (en) | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
US5514785A (en) | 1990-05-11 | 1996-05-07 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
US5147777A (en) | 1990-06-18 | 1992-09-15 | Eastman Kodak Company | Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
US5281370A (en) | 1990-08-22 | 1994-01-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of making solid crystalline narrow band radiation filter |
US5208111A (en) | 1990-08-25 | 1993-05-04 | Bayer Aktiengesellschaft | One- or multi-layered layer elements applied to supports and their production |
US5266497A (en) | 1990-08-31 | 1993-11-30 | Japan Synthetic Rubber Co., Ltd. | Immunochromatographic assay with improved colored latex |
US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
DE4035714C2 (en) | 1990-11-09 | 1993-03-04 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
US5474895A (en) | 1990-11-14 | 1995-12-12 | Siska Diagnostics Inc. | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
US5422246A (en) | 1990-12-14 | 1995-06-06 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Electrode having a polymer coating with a redox enzyme bound thereto, the polymer coating being formed on the walls of pores extending through a porous membrane |
US5266238A (en) | 1990-12-24 | 1993-11-30 | American Cyanamid Company | Narrow band radiation filter films |
US5301044A (en) | 1990-12-31 | 1994-04-05 | Xerox Corporation | Marking material containing a taggant, and method of producing an image |
US5105305A (en) | 1991-01-10 | 1992-04-14 | At&T Bell Laboratories | Near-field scanning optical microscope using a fluorescent probe |
US5128006A (en) | 1991-01-23 | 1992-07-07 | At&T Bell Laboratories | Deposition of diamond films on semicondutor substrates |
US5250264A (en) | 1991-01-25 | 1993-10-05 | Trustees Of Tufts College | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
US5308749A (en) | 1991-01-25 | 1994-05-03 | Eastman Kodak Company | Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use |
US5320814A (en) | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
US5244813A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
US5364759A (en) | 1991-01-31 | 1994-11-15 | Baylor College Of Medicine | DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5364759B1 (en) | 1991-01-31 | 1997-11-18 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and indentification of polymorphic short tandem repeats |
US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5288577A (en) | 1991-02-27 | 1994-02-22 | Ricoh Company, Ltd. | Dry-type developer |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US5552270A (en) | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
EP0529775A1 (en) | 1991-06-28 | 1993-03-03 | Oki Electric Industry Co., Ltd. | Arraying process of ultra-small objects and fabrication process of ultra-fine structure by using the arraying process |
US5567627A (en) | 1991-07-16 | 1996-10-22 | Trans-Med Biotech, Incorporated | Method and composition for the simultaneous and discrete analysis of multiple analytes |
US5187096A (en) | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
US5627040A (en) | 1991-08-28 | 1997-05-06 | Becton Dickinson And Company | Flow cytometric method for autoclustering cells |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
US5650488A (en) | 1991-09-18 | 1997-07-22 | British Technology Group Limited | Polypeptide inhibitor of the replication of HSV |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5993935A (en) | 1991-10-11 | 1999-11-30 | 3M Innovative Properties Company | Covalently reactive particles incorporated in a continous porous matrix |
US5516635A (en) | 1991-10-15 | 1996-05-14 | Ekins; Roger P. | Binding assay employing labelled reagent |
US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
US5532128A (en) | 1991-11-19 | 1996-07-02 | Houston Advanced Research Center | Multi-site detection apparatus |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5653939A (en) | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5652059A (en) | 1991-11-20 | 1997-07-29 | Bar Ilan University | Method for attaching microspheres to a substrate |
US5326691A (en) | 1991-11-21 | 1994-07-05 | John Hozier | Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries |
US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
US5552086A (en) | 1992-01-29 | 1996-09-03 | Coulter Corporation | Immobilized metal colloids on dispersed polymer microspheres |
US5221417A (en) | 1992-02-20 | 1993-06-22 | At&T Bell Laboratories | Conductive adhesive film techniques |
US5382801A (en) | 1992-04-15 | 1995-01-17 | Agency Of Industrial Science And Technology | Method for producing minute particles and apparatus therefor |
US5667667A (en) | 1992-04-24 | 1997-09-16 | Isis Innovation Limited | Electrochemical treatment of surfaces |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US5308586A (en) | 1992-05-01 | 1994-05-03 | General Atomics | Electrostatic separator using a bead bed |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5573909A (en) | 1992-05-13 | 1996-11-12 | Molecular Probes, Inc. | Fluorescent labeling using microparticles with controllable stokes shift |
US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
US5326692A (en) | 1992-05-13 | 1994-07-05 | Molecular Probes, Inc. | Fluorescent microparticles with controllable enhanced stokes shift |
US5773222A (en) | 1992-05-27 | 1998-06-30 | National Blood Authority | Solid phase immunological assay |
US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
US5518883A (en) | 1992-07-02 | 1996-05-21 | Soini; Erkki J. | Biospecific multiparameter assay method |
US5488567A (en) | 1992-07-23 | 1996-01-30 | Acrogen, Inc. | Digital analyte detection system |
US5329461A (en) | 1992-07-23 | 1994-07-12 | Acrogen, Inc. | Digital analyte detection system |
US5674698A (en) | 1992-09-14 | 1997-10-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5415835A (en) | 1992-09-16 | 1995-05-16 | University Of New Mexico | Method for fine-line interferometric lithography |
US5442246A (en) | 1992-09-29 | 1995-08-15 | Fujitsu Limited | Programmable logic circuit |
US5968736A (en) | 1992-10-01 | 1999-10-19 | Cold Spring Harbor Laboratory | Methods for recording the reaction history of a solid support |
US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5714340A (en) | 1992-12-22 | 1998-02-03 | Johnson & Johnson Clinical Diagnostics, Inc. | Immunoassay elements having a receptor zone |
US5298741A (en) | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
US5652107A (en) | 1993-01-15 | 1997-07-29 | The Public Health Research Institute Of The City Of New York, Inc. | Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase |
US5637508A (en) | 1993-03-26 | 1997-06-10 | Geo-Centers, Inc. | Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same |
US5643765A (en) | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5470534A (en) | 1993-05-10 | 1995-11-28 | Hitachi, Ltd. | Analytical system useful in diagnosis of the condition of a disease |
US6090912A (en) | 1993-05-27 | 2000-07-18 | Selectide Corporation | Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond |
US5840485A (en) | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
US5528392A (en) | 1993-06-07 | 1996-06-18 | Fuji Photo Film Co., Ltd. | Image-forming apparatus having liquid crystal and photoconductive members and using the same light beam for reading and writing |
US5512157A (en) | 1993-06-21 | 1996-04-30 | Helena Laboratories Corporation | Electrophoresis plate |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5648124A (en) | 1993-07-09 | 1997-07-15 | Seradyn, Inc. | Process for preparing magnetically responsive microparticles |
US5837501A (en) | 1993-07-09 | 1998-11-17 | Akzo Nobel N.V. | Nucleic acid quantitation by co-amplification of target with multiple internal controls |
US5770455A (en) | 1993-07-19 | 1998-06-23 | Ontogen Corporation | Methods and apparatus for synthesizing labeled combinatorial chemistrylibraries |
US6218111B1 (en) | 1993-07-30 | 2001-04-17 | Oxford Gene Technology Limited | Tag reagent and assay method |
US5770367A (en) | 1993-07-30 | 1998-06-23 | Oxford Gene Technology Limited | Tag reagent and assay method |
US5770721A (en) | 1993-08-11 | 1998-06-23 | University Of Chicago | Method of manufacturing a matrix for the detection of mismatches |
US5382512A (en) | 1993-08-23 | 1995-01-17 | Chiron Corporation | Assay device with captured particle reagent |
US6251687B1 (en) | 1993-09-24 | 2001-06-26 | Biosite Diagnostics, Inc. | Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds |
US5447440A (en) | 1993-10-28 | 1995-09-05 | I-Stat Corporation | Apparatus for assaying viscosity changes in fluid samples and method of conducting same |
US6319472B1 (en) | 1993-11-01 | 2001-11-20 | Nanogen, Inc. | System including functionally separated regions in electrophoretic system |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US6245508B1 (en) | 1993-11-01 | 2001-06-12 | Nanogen, Inc. | Method for fingerprinting utilizing an electronically addressable array |
US6309602B1 (en) | 1993-11-01 | 2001-10-30 | Nanogen, Inc. | Stacked, reconfigurable system for electrophoretic transport of charged materials |
US6068818A (en) | 1993-11-01 | 2000-05-30 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
US6254827B1 (en) | 1993-11-01 | 2001-07-03 | Nanogen, Inc. | Methods for fabricating multi-component devices for molecular biological analysis and diagnostics |
US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5837551A (en) | 1993-12-24 | 1998-11-17 | Ekins; Roger P. | Binding assay |
US5496997A (en) | 1994-01-03 | 1996-03-05 | Pope; Edward J. A. | Sensor incorporating an optical fiber and a solid porous inorganic microsphere |
US6080585A (en) | 1994-02-01 | 2000-06-27 | Oxford Gene Technology Limited | Methods for discovering ligands |
US5952174A (en) | 1994-02-07 | 1999-09-14 | Orchid Biocomputer, Inc. | Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis |
US5679524A (en) | 1994-02-07 | 1997-10-21 | Molecular Tool, Inc. | Ligase/polymerase mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis |
US5468649A (en) | 1994-02-15 | 1995-11-21 | Abbott Laboratories | Process for labeling acridinium to microparticles and application in an instrument |
US5942388A (en) | 1994-02-22 | 1999-08-24 | Yissum Research Development Company Of The Hebrew University Of Jersaleum | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium, and electrodes thereof |
US6316186B1 (en) | 1994-03-11 | 2001-11-13 | Multilyte Limited | Binding assay using binding agents with tail groups |
US5674686A (en) | 1994-03-28 | 1997-10-07 | Promega Corporation | Allelic ladders for short tandem repeat loci |
US5714521A (en) | 1994-04-07 | 1998-02-03 | Yeda Research And Development Company Ltd. | Ion exchange membranes |
US5602042A (en) | 1994-04-14 | 1997-02-11 | Cytyc Corporation | Method and apparatus for magnetically separating biological particles from a mixture |
US5593839A (en) | 1994-05-24 | 1997-01-14 | Affymetrix, Inc. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US6015666A (en) | 1994-06-23 | 2000-01-18 | Bayer Aktiengesellschaft | Rapid DNA test for detecting quinolone-resistant Staphylococcus aureus pathogens in clinical material |
US5763198A (en) | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
US5512490A (en) | 1994-08-11 | 1996-04-30 | Trustees Of Tufts College | Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns |
US5582988A (en) | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
US5898071A (en) | 1994-09-20 | 1999-04-27 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
US5843660A (en) | 1994-09-30 | 1998-12-01 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
US6221598B1 (en) | 1994-09-30 | 2001-04-24 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
US5844304A (en) | 1994-09-30 | 1998-12-01 | Nec Corporation | Process for manufacturing semiconductor device and semiconductor wafer |
US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US6172218B1 (en) | 1994-10-13 | 2001-01-09 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US6141046A (en) | 1994-10-25 | 2000-10-31 | Roth; Stephen Anthony | Electronic camera having an illuminator with dispersing ring lens |
US5858804A (en) | 1994-11-10 | 1999-01-12 | Sarnoff Corporation | Immunological assay conducted in a microlaboratory array |
US5593838A (en) | 1994-11-10 | 1997-01-14 | David Sarnoff Research Center, Inc. | Partitioned microelectronic device array |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US6153375A (en) | 1994-11-18 | 2000-11-28 | Cambridge Combinatorial Limited | Method of making a library of compounds using a functionalized polymer support resin affixed to a laminar material |
US5527710A (en) | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
US6090458A (en) | 1994-12-22 | 2000-07-18 | Nec Corporation | Method and apparatus for film formation by chemical vapor deposition |
US5567304A (en) | 1995-01-03 | 1996-10-22 | Ibm Corporation | Elimination of island formation and contact resistance problems during electroetching of blanket or patterned thin metallic layers on insulating substrate |
US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US6090545A (en) | 1995-03-10 | 2000-07-18 | Meso Scale Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US6150095A (en) | 1995-04-07 | 2000-11-21 | Oxford Gene Technology Limited | Method for analyzing a polynucleotide containing a variable sequence |
US6307039B1 (en) | 1995-04-07 | 2001-10-23 | Oxford Gene Technology Limited | Method for analyzing a polynucleotide containing a variable sequence and a set or array of oligonucleotides therefor |
US5961923A (en) | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US6063569A (en) | 1995-06-07 | 2000-05-16 | Perseptive Biosystems, Inc. | Methods for automated synthesis of PNA-DNA chimeras and compositions thereof |
US5874219A (en) | 1995-06-07 | 1999-02-23 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US6261430B1 (en) | 1995-06-08 | 2001-07-17 | Visible Genetics Inc. | Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules |
US5728529A (en) | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
US5945525A (en) | 1995-07-07 | 1999-08-31 | Toyo Boseki Kabushiki Kaisha | Method for isolating nucleic acids using silica-coated magnetic particles |
US6515649B1 (en) | 1995-07-20 | 2003-02-04 | E Ink Corporation | Suspended particle displays and materials for making the same |
US6514688B2 (en) | 1995-07-31 | 2003-02-04 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Separating, detecting or quantifying biological materials using magnetic cross-linked polyvinyl alcohol particles |
US6531292B1 (en) | 1995-08-17 | 2003-03-11 | The Regents Of The University Of California | Genes and proteins controlling cholesterol synthesis |
US5660990A (en) | 1995-08-18 | 1997-08-26 | Immunivest Corporation | Surface immobilization of magnetically collected materials |
US6200737B1 (en) | 1995-08-24 | 2001-03-13 | Trustees Of Tufts College | Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure |
US5633724A (en) | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
US5994066A (en) | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US5866331A (en) | 1995-10-20 | 1999-02-02 | University Of Massachusetts | Single molecule detection by in situ hybridization |
US5744299A (en) | 1995-11-03 | 1998-04-28 | Mcw Research Foundation | Human parainfluenza virus-1 assay |
US6015664A (en) | 1995-11-03 | 2000-01-18 | Mcw Research Foundation | Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B |
US5722470A (en) | 1995-11-09 | 1998-03-03 | Glaxo Group Limited | Bead dispensing device and methods |
US5763175A (en) | 1995-11-17 | 1998-06-09 | Lynx Therapeutics, Inc. | Simultaneous sequencing of tagged polynucleotides |
US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US5633972A (en) | 1995-11-29 | 1997-05-27 | Trustees Of Tufts College | Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy |
US6007996A (en) | 1995-12-12 | 1999-12-28 | Applied Spectral Imaging Ltd. | In situ method of analyzing cells |
US5814524A (en) | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
US5766963A (en) | 1996-01-26 | 1998-06-16 | Pharmacopeia, Inc. | Combination hydroxypropylamine library |
US6043354A (en) | 1996-01-31 | 2000-03-28 | Invitek Gmbh | Method for the simultaneous isolation of genomic DNA and high-purity RNA |
US5723233A (en) | 1996-02-27 | 1998-03-03 | Lsi Logic Corporation | Optical proximity correction method and apparatus |
US6760157B1 (en) | 1996-02-29 | 2004-07-06 | 3M Innovative Properties Company | Brightness enhancement film |
US6297062B1 (en) | 1996-03-07 | 2001-10-02 | Bio-Magnetics Ltd. | Separation by magnetic particles |
US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
US6193866B1 (en) | 1996-03-27 | 2001-02-27 | Curagen Corporation | Separation of charged particles by a spatially and temporally varying electric field |
US5716852A (en) | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US7056746B2 (en) | 1996-04-25 | 2006-06-06 | Bioarray Solutions Ltd. | Array cytometry |
US7390676B2 (en) | 1996-04-25 | 2008-06-24 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US6514771B1 (en) | 1996-04-25 | 2003-02-04 | Bioarray Solutions | Light-controlled electrokinetic assembly of particles near surfaces |
US7144119B2 (en) | 1996-04-25 | 2006-12-05 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US7358097B2 (en) | 1996-04-25 | 2008-04-15 | Bio Array Solutions Ltd. | Making a matrix of random encoded arrays |
US6468811B1 (en) | 1996-04-25 | 2002-10-22 | Bioarray Solutions | Light-controlled electrokinetic assembly of particles near surfaces |
US20030228610A1 (en) | 1996-04-25 | 2003-12-11 | Michael Seul | Encoded beads having oligonucleotides attached and formed in arrays |
US7090759B1 (en) | 1996-04-25 | 2006-08-15 | Bioarray Solutions Ltd. | Apparatus and method for light-controlled electrokinetic assembly of particles near surfaces |
US7749774B2 (en) | 1996-04-25 | 2010-07-06 | Michael Seul | Arrays formed of encoded beads having ligands attached |
US6797524B1 (en) | 1996-04-25 | 2004-09-28 | Bioarray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
US7291504B2 (en) | 1996-04-25 | 2007-11-06 | Bioarray Solutions Ltd. | Assay involving detection and identification with encoded particles |
US6991941B1 (en) | 1996-04-25 | 2006-01-31 | Bioarray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
US6958245B2 (en) | 1996-04-25 | 2005-10-25 | Bioarray Solutions Ltd. | Array cytometry |
US6955751B1 (en) | 1996-04-25 | 2005-10-18 | Bioarray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US20030022393A1 (en) | 1996-04-25 | 2003-01-30 | Michael Seul | Array cytometry |
US6251691B1 (en) | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
US7615345B2 (en) | 1996-04-25 | 2009-11-10 | Bio Array Solutions Ltd. | Arrays formed of encoded beads having oligonucleotides attached |
US7427512B2 (en) | 1996-04-25 | 2008-09-23 | Bioarray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
US6083699A (en) | 1996-05-01 | 2000-07-04 | Visible Genetics Inc. | Method for bi-directional sequencing of nucleic acid polymers |
US6084991A (en) | 1996-05-23 | 2000-07-04 | Agilent Technologies Inc. | CCD imager for confocal scanning microscopy |
US6023590A (en) | 1996-05-24 | 2000-02-08 | Asahi Kogaku Kogyo Kabushiki Kaisha | Image recording device |
US6027889A (en) | 1996-05-29 | 2000-02-22 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6267858B1 (en) | 1996-06-28 | 2001-07-31 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
US6075905A (en) | 1996-07-17 | 2000-06-13 | Sarnoff Corporation | Method and apparatus for mosaic image construction |
US6312134B1 (en) | 1996-07-25 | 2001-11-06 | Anvik Corporation | Seamless, maskless lithography system using spatial light modulator |
US6264815B1 (en) | 1996-07-26 | 2001-07-24 | Btg International Limited | Apparatus and method for testing using dielectrophoresis |
US20040219520A1 (en) | 1996-07-29 | 2004-11-04 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6180226B1 (en) | 1996-08-01 | 2001-01-30 | Loctite (R&D) Limited | Method of forming a monolayer of particles, and products formed thereby |
US6086736A (en) | 1996-08-02 | 2000-07-11 | Texas Tech University | Electromigration injection from a microreservoir-electrode in capillary separation systems |
US5831045A (en) | 1996-08-05 | 1998-11-03 | Porlinx, Incorporated | Boronic acid-containing polynucleotides |
US5792430A (en) | 1996-08-12 | 1998-08-11 | Monsanto Company | Solid phase organic synthesis device with pressure-regulated manifold |
US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US6650703B1 (en) | 1996-08-23 | 2003-11-18 | Deutsche Telekom Ag | Picture-transmitting remote object inspection system |
US5766711A (en) | 1996-08-29 | 1998-06-16 | Barmakian; Andrew | Composite camel structure and method for manufacture |
US6120666A (en) | 1996-09-26 | 2000-09-19 | Ut-Battelle, Llc | Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same |
US6124092A (en) | 1996-10-04 | 2000-09-26 | The Perkin-Elmer Corporation | Multiplex polynucleotide capture methods and compositions |
US6209589B1 (en) | 1996-10-21 | 2001-04-03 | Smithkline Beecham Plc | Apparatus and method for distributing beads |
US5786219A (en) | 1996-10-28 | 1998-07-28 | Molecular Probes, Inc. | Microspheres with fluorescent spherical zones |
US6018350A (en) | 1996-10-29 | 2000-01-25 | Real 3D, Inc. | Illumination and shadow simulation in a computer graphics/imaging system |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US20020031841A1 (en) | 1996-11-06 | 2002-03-14 | Asher Sanford A. | Colorimetric reagent |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US5965235A (en) | 1996-11-08 | 1999-10-12 | The Procter & Gamble Co. | Three-dimensional, amorphous-patterned, nesting-resistant sheet materials and method and apparatus for making same |
US5776711A (en) | 1996-11-12 | 1998-07-07 | The Regents Of The University Of California | Simultaneous human ABO and RH(D) blood typing or antibody screening by flow cytometry |
US5855753A (en) | 1996-11-26 | 1999-01-05 | The Trustees Of Princeton University | Method for electrohydrodynamically assembling patterned colloidal structures |
US6033547A (en) | 1996-11-26 | 2000-03-07 | The Trustees Of Princeton University | Apparatus for electrohydrodynamically assembling patterned colloidal structures |
US6458547B1 (en) | 1996-12-12 | 2002-10-01 | Prolume, Ltd. | Apparatus and method for detecting and identifying infectious agents |
US6143499A (en) | 1996-12-17 | 2000-11-07 | University Of Chicago | Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing |
US6025905A (en) | 1996-12-31 | 2000-02-15 | Cognex Corporation | System for obtaining a uniform illumination reflectance image during periodic structured illumination |
US6083763A (en) | 1996-12-31 | 2000-07-04 | Genometrix Inc. | Multiplexed molecular analysis apparatus and method |
US6100030A (en) | 1997-01-10 | 2000-08-08 | Pioneer Hi-Bred International, Inc. | Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening |
US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
US5939021A (en) | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
US5812272A (en) | 1997-01-30 | 1998-09-22 | Hewlett-Packard Company | Apparatus and method with tiled light source array for integrated assay sensing |
US6151062A (en) | 1997-02-18 | 2000-11-21 | Canon Kabushiki Kaisha | Stereoscopic image display apparatus using specific mask pattern |
US5989835A (en) | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
US6266459B1 (en) | 1997-03-14 | 2001-07-24 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
US6399328B1 (en) | 1997-03-21 | 2002-06-04 | Musc Foundation For Research Development | Methods and compositions for diagnosis and treatment of breast cancer |
US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6193951B1 (en) | 1997-04-30 | 2001-02-27 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents |
US6106685A (en) | 1997-05-13 | 2000-08-22 | Sarnoff Corporation | Electrode combinations for pumping fluids |
US5948627A (en) | 1997-05-30 | 1999-09-07 | One Lambda | Immunobead flow cytometric detection of anti-HLA panel-reactive antibody |
US6514714B1 (en) | 1997-05-30 | 2003-02-04 | One Lambda | Method for immunobead flow cytometric detection of anti-HLA panel reactive antibody |
US5876946A (en) | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US6368799B1 (en) | 1997-06-13 | 2002-04-09 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
US6060243A (en) | 1997-07-17 | 2000-05-09 | Procrea Biosciences Inc. | Primers for obtaining highly informative DNA markers |
US7099777B1 (en) | 1997-09-05 | 2006-08-29 | Affymetrix, Inc. | Techniques for identifying confirming mapping and categorizing nucleic acids |
US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US5948621A (en) | 1997-09-30 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Direct molecular patterning using a micro-stamp gel |
US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US6014451A (en) | 1997-10-17 | 2000-01-11 | Pioneer Hi-Bred International, Inc. | Remote imaging system for plant diagnosis |
US6077669A (en) | 1997-11-04 | 2000-06-20 | Becton Dickinson And Company | Kit and method for fluorescence based detection assay |
US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
US6280618B2 (en) | 1997-11-18 | 2001-08-28 | Bio-Rad Laboratories, Inc. | Multiplex flow assays preferably with magnetic particles as solid phase |
US6342355B1 (en) | 1997-11-26 | 2002-01-29 | The United States Of America As Represented By The Department Of Health & Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
US6321791B1 (en) | 1998-01-20 | 2001-11-27 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
US6268222B1 (en) | 1998-01-22 | 2001-07-31 | Luminex Corporation | Microparticles attached to nanoparticles labeled with flourescent dye |
US6123263A (en) | 1998-01-29 | 2000-09-26 | Meta Holdings Corporation | Hand held dataform reader having strobing ultraviolet light illumination assembly for reading fluorescent dataforms |
US7132239B2 (en) | 1998-02-04 | 2006-11-07 | Applera Corporation | Determination of a genotype of an amplification product at multiple allelic sites |
US6238863B1 (en) | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
US6277579B1 (en) | 1998-02-06 | 2001-08-21 | Digene Corporation | Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function |
US6349144B1 (en) | 1998-02-07 | 2002-02-19 | Biodiscovery, Inc. | Automated DNA array segmentation and analysis |
US6122599A (en) | 1998-02-13 | 2000-09-19 | Mehta; Shailesh | Apparatus and method for analyzing particles |
US6426615B1 (en) | 1998-02-13 | 2002-07-30 | Shailesh Mehta | Apparatus and method for analyzing particles |
US6096368A (en) | 1998-02-19 | 2000-08-01 | Delsys Pharmaceutical Corporation | Bead transporter chucks using repulsive field guidance and method |
US6605474B1 (en) | 1998-02-24 | 2003-08-12 | Genevac Limited | Method and apparatus for determining temperature of and controlling the evaporation of liquid samples |
US6318970B1 (en) | 1998-03-12 | 2001-11-20 | Micralyne Inc. | Fluidic devices |
US5988432A (en) | 1998-03-25 | 1999-11-23 | Sarnoff Corporation | Bead manipulating chucks with bead size selector |
US6494924B1 (en) | 1998-04-03 | 2002-12-17 | Basf Aktiengesellschaft | Precipitated water-insoluble colorants in colloid disperse form |
US6955902B2 (en) | 1998-04-10 | 2005-10-18 | Serono Genetics Institute, Inc. | High throughput DNA sequencing vector |
US6355419B1 (en) | 1998-04-27 | 2002-03-12 | Hyseq, Inc. | Preparation of pools of nucleic acids based on representation in a sample |
US5952131A (en) | 1998-04-27 | 1999-09-14 | Xerox Corporation | Core and shell matrix compositions and processes |
US20030087228A1 (en) | 1998-05-06 | 2003-05-08 | Cynthia Bamdad | Electronic detection of nucleic acids using monolayers |
US6251592B1 (en) | 1998-05-26 | 2001-06-26 | Procrea Biosciences Inc. | STR marker system for DNA fingerprinting |
US6139831A (en) | 1998-05-28 | 2000-10-31 | The Rockfeller University | Apparatus and method for immobilizing molecules onto a substrate |
US20010049095A1 (en) | 1998-06-01 | 2001-12-06 | Teresa A. Webster | Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions |
US6251595B1 (en) | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
US6264825B1 (en) | 1998-06-23 | 2001-07-24 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
US6361945B1 (en) | 1998-07-02 | 2002-03-26 | Gen-Probe Incorporated | Molecular torches |
US6534274B2 (en) | 1998-07-02 | 2003-03-18 | Gen-Probe Incorporated | Molecular torches |
US6365418B1 (en) | 1998-07-14 | 2002-04-02 | Zyomyx, Incorporated | Arrays of protein-capture agents and methods of use thereof |
US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6001614A (en) | 1998-07-24 | 1999-12-14 | Lumigen, Inc. | Methods of synthesizing labeled polynucleotides by ligation of multiple oligomers |
US6254754B1 (en) | 1998-07-29 | 2001-07-03 | Agilent Technologies, Inc. | Chip for performing an electrophoretic separation of molecules and method using same |
US20010044531A1 (en) | 1998-07-31 | 2001-11-22 | Mcgall Glenn | Nucleic acid labeling compounds |
US6132685A (en) | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6126731A (en) | 1998-08-21 | 2000-10-03 | Idea Development Company | Polymerizable ink composition |
US6306643B1 (en) | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
US6136468A (en) | 1998-08-25 | 2000-10-24 | Timer Technologies, Llc | Electrochemical cell with deferred assembly |
US6183970B1 (en) | 1998-08-27 | 2001-02-06 | Hitachi, Ltd. | Polynucleotide probe chip and polynucleotide detection method |
US20040175734A1 (en) | 1998-08-28 | 2004-09-09 | Febit Ferrarius Biotechnology Gmbh | Support for analyte determination methods and method for producing the support |
US20070031877A1 (en) | 1998-08-28 | 2007-02-08 | Febit Biotech Gmbh | Support for analyte determination methods and method for producing the support |
US7737088B1 (en) | 1998-08-28 | 2010-06-15 | Febit Holding Gmbh | Method and device for producing biochemical reaction supporting materials |
US20080214412A1 (en) | 1998-08-28 | 2008-09-04 | Stahler Cord F | Method and device for preparing and/or analyzing biochemical reaction carriers |
US7097974B1 (en) | 1998-08-28 | 2006-08-29 | Febit Biotech Gmbh | Support for a method for determining an analyte and a method for producing the support |
US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
US6136171A (en) | 1998-09-18 | 2000-10-24 | The University Of Utah Research Foundation | Micromachined electrical field-flow fractionation system |
US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
US6187540B1 (en) | 1998-11-09 | 2001-02-13 | Identigene, Inc. | Method of newborn identification and tracking |
US20030012699A1 (en) | 1998-11-18 | 2003-01-16 | Thomas Moore | Simultaneous handling of magnetic beads in a two-dimensional arrangement |
US6271856B1 (en) | 1998-11-19 | 2001-08-07 | Paraform, Inc. | Creating and modifying parameterizations of surfaces |
US20050239098A1 (en) | 1998-12-23 | 2005-10-27 | Human Genome Sciences, Inc. | Novel hyaluronan-binding proteins and encoding genes |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
US6534293B1 (en) | 1999-01-06 | 2003-03-18 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
US6743581B1 (en) | 1999-01-25 | 2004-06-01 | Ut-Battelle, Lc | Multifunctional and multispectral biosensor devices and methods of use |
US6531323B1 (en) | 1999-01-28 | 2003-03-11 | Fuji Photo Film Co., Ltd. | Agglutination assay method and element in a dry system |
US20020150909A1 (en) | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6153389A (en) | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
US20020022276A1 (en) | 1999-03-15 | 2002-02-21 | Yuxiang Zhou | Individually addressable micro-electromagnetic unit array chips |
US6806050B2 (en) | 1999-03-15 | 2004-10-19 | Aviva Biosciences | Individually addressable micro-electromagnetic unit array chips |
US6355491B1 (en) | 1999-03-15 | 2002-03-12 | Aviva Biosciences | Individually addressable micro-electromagnetic unit array chips |
US6403309B1 (en) | 1999-03-19 | 2002-06-11 | Valigen (Us), Inc. | Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays |
US6261782B1 (en) | 1999-04-06 | 2001-07-17 | Yale University | Fixed address analysis of sequence tags |
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US20020006634A1 (en) | 1999-05-11 | 2002-01-17 | Han In Suk | Methods and compositions for use of catalase in hydrogels and biosensors |
US20020125138A1 (en) | 1999-05-18 | 2002-09-12 | Gianni Medoro | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
US6620584B1 (en) | 1999-05-20 | 2003-09-16 | Illumina | Combinatorial decoding of random nucleic acid arrays |
US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
US6955889B1 (en) | 1999-06-08 | 2005-10-18 | Ortho-Clinical Diagnostics, Inc. | Simultaneous determination of forward and reverse ABO blood group |
US6692914B1 (en) | 1999-07-02 | 2004-02-17 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
US6303316B1 (en) | 1999-07-02 | 2001-10-16 | Conceptual Mind Works, Inc. | Organic semiconductor recognition complex and system |
US6268219B1 (en) | 1999-07-09 | 2001-07-31 | Orchid Biosciences, Inc. | Method and apparatus for distributing fluid in a microfluidic device |
US6488872B1 (en) | 1999-07-23 | 2002-12-03 | The Board Of Trustees Of The University Of Illinois | Microfabricated devices and method of manufacturing the same |
US6887701B2 (en) | 1999-07-30 | 2005-05-03 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
US20020015952A1 (en) | 1999-07-30 | 2002-02-07 | Anderson Norman G. | Microarrays and their manufacture by slicing |
US6713309B1 (en) | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
US20040087032A1 (en) * | 1999-08-17 | 2004-05-06 | Chandler Mark B. | Microparticles with multiple fluorescent signals and methods of using same |
US6942968B1 (en) | 1999-08-30 | 2005-09-13 | Illumina, Inc. | Array compositions for improved signal detection |
US6319674B1 (en) | 1999-09-16 | 2001-11-20 | Agilent Technologies, Inc. | Methods for attaching substances to surfaces |
US6287778B1 (en) | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
US6844156B2 (en) | 1999-10-19 | 2005-01-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods for identifying a preferred liver transplant donor |
US6077674A (en) | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
US6451191B1 (en) | 1999-11-18 | 2002-09-17 | 3M Innovative Properties Company | Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same |
US6605453B2 (en) | 1999-12-01 | 2003-08-12 | The Regents Of The University Of California | Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells |
US6361916B1 (en) | 1999-12-14 | 2002-03-26 | Eastman Kodak Company | Loaded latex compositions with dye and stabilizer |
US20020197728A1 (en) | 1999-12-15 | 2002-12-26 | Howard Kaufman | Methods of monitoring effects of chemical agents on a sample |
US6500620B2 (en) | 1999-12-29 | 2002-12-31 | Mergen Ltd. | Methods for amplifying and detecting multiple polynucleotides on a solid phase support |
US6897271B1 (en) | 2000-01-05 | 2005-05-24 | Novartis Ag | Porous hydrogels |
US20030004594A1 (en) | 2000-02-02 | 2003-01-02 | Liu Vincent Bardina | Flexible manufacturing system |
US6890741B2 (en) | 2000-02-07 | 2005-05-10 | Illumina, Inc. | Multiplexed detection of analytes |
US6812005B2 (en) | 2000-02-07 | 2004-11-02 | The Regents Of The University Of California | Nucleic acid detection methods using universal priming |
US20020039728A1 (en) | 2000-02-10 | 2002-04-04 | Robert Kain | Alternative substrates and formats for bead-based array of arrays |
US20030031351A1 (en) | 2000-02-11 | 2003-02-13 | Yim Peter J. | Vessel delineation in magnetic resonance angiographic images |
US20030108913A1 (en) | 2000-02-15 | 2003-06-12 | Schouten Johannes Petrus | Multiplex ligatable probe amplification |
US6993156B1 (en) | 2000-02-18 | 2006-01-31 | Microsoft Corporation | System and method for statistically comparing and matching plural sets of digital data |
US20030154108A1 (en) | 2000-03-01 | 2003-08-14 | Gambro, Inc. | Extracorporeal blood processing information management system |
US20010034614A1 (en) | 2000-03-01 | 2001-10-25 | Peter Fletcher-Haynes | Extracorporeal blood processing information management system |
US6358387B1 (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods |
US20010046602A1 (en) | 2000-04-06 | 2001-11-29 | Chandler Don J. | Magnetically-responsive microspheres |
US20020081714A1 (en) | 2000-05-05 | 2002-06-27 | Maneesh Jain | Devices and methods to form a randomly ordered array of magnetic beads and uses thereof |
US20020029235A1 (en) | 2000-05-11 | 2002-03-07 | Becton Dickinson And Company | System for identifying clusters in scatter plots using smoothed polygons with optimal boundaries |
US20040009614A1 (en) | 2000-05-12 | 2004-01-15 | Ahn Chong H | Magnetic bead-based arrays |
US6645432B1 (en) | 2000-05-25 | 2003-11-11 | President & Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
US20040132122A1 (en) | 2000-06-21 | 2004-07-08 | Sukanta Banerjee | Multianalyte molecular analysis using application-specific random particle arrays |
US20020032252A1 (en) | 2000-07-06 | 2002-03-14 | Takahiro Ishizuka | Colored particulate dispersion, ink for ink-jet recording using the same, and ink-jet recording method |
US20040014073A1 (en) | 2000-08-08 | 2004-01-22 | Dieter Trau | Capsules encapsulating solid particles of signal-generating organic substances and their use in vitro bioassays for detection of target molecules in a sample |
US6824981B2 (en) * | 2000-08-11 | 2004-11-30 | Agilix Corporation | Ultra-sensitive detection systems using alterable peptide tags |
US20020182609A1 (en) | 2000-08-16 | 2002-12-05 | Luminex Corporation | Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping |
US6670128B2 (en) | 2000-08-16 | 2003-12-30 | Whatman, Inc. | Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies |
US20030012693A1 (en) | 2000-08-24 | 2003-01-16 | Imego Ab | Systems and methods for localizing and analyzing samples on a bio-sensor chip |
US20020045169A1 (en) | 2000-08-25 | 2002-04-18 | Shoemaker Daniel D. | Gene discovery using microarrays |
US6521747B2 (en) | 2000-08-28 | 2003-02-18 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the AGTR1 gene |
US20020198665A1 (en) | 2000-09-17 | 2002-12-26 | Michael Seul | System and method for programmable illumination pattern generation |
US6498863B1 (en) | 2000-09-20 | 2002-12-24 | Media Cybernetics Inc. | Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay |
US20020127603A1 (en) | 2000-10-12 | 2002-09-12 | Amnis Corporation | Methods for synthesizing reporter labeled beads |
US20030038812A1 (en) | 2000-10-24 | 2003-02-27 | Affymetrix, Inc. A Corporation Organized Under The Laws Of Delaware | Computer software system, method, and product for scanned image alignment |
US6528264B1 (en) | 2000-11-01 | 2003-03-04 | Corning Incorporated | Polymer support for DNA immobilization |
US7229840B1 (en) | 2000-11-02 | 2007-06-12 | Andreas Hofmann | Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels |
US20020137074A1 (en) | 2000-11-21 | 2002-09-26 | Piunno Paul A.E. | Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry |
US20040106121A1 (en) | 2000-11-29 | 2004-06-03 | Commissariat A L'energie Atomique | Static micro-array of biological or chemical probes immobilised on a support by magnetic attraction |
US6905881B2 (en) | 2000-11-30 | 2005-06-14 | Paul Sammak | Microbead-based test plates and test methods for fluorescence imaging systems |
US20020187501A1 (en) | 2001-01-26 | 2002-12-12 | Mingxian Huang | Microdevices having a preferential axis of magnetization and uses thereof |
US7262016B2 (en) | 2001-01-26 | 2007-08-28 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
US20060024732A1 (en) | 2001-01-26 | 2006-02-02 | Mingxian Huang | Microdevices having a preferential axis of magnetization and uses thereof |
US7015047B2 (en) | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
US6779559B2 (en) | 2001-01-29 | 2004-08-24 | Caliper Life Sciences, Inc. | Non-mechanical valves for fluidic systems |
US20020155481A1 (en) | 2001-02-08 | 2002-10-24 | Ngk Insulators, Ltd. | Biochip and method for producing the same |
US20080200349A1 (en) | 2001-02-28 | 2008-08-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
US20030077607A1 (en) | 2001-03-10 | 2003-04-24 | Hopfinger Anton J. | Methods and tools for nucleic acid sequence analysis, selection, and generation |
US6706163B2 (en) | 2001-03-21 | 2004-03-16 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US20020166766A1 (en) | 2001-03-21 | 2002-11-14 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US20020142318A1 (en) | 2001-03-30 | 2002-10-03 | Cattell Herbert F. | Chemical array reading |
US20040137641A1 (en) | 2001-04-24 | 2004-07-15 | Jostein Holtlund | Haemoglobin assay |
US6703288B2 (en) | 2001-05-10 | 2004-03-09 | Hoya Corporation | Compound crystal and method of manufacturing same |
US20030006143A1 (en) | 2001-06-21 | 2003-01-09 | Sukanta Banerjee | Directed assembly of functional heterostructures |
US20030003272A1 (en) | 2001-06-21 | 2003-01-02 | Bruno Laguitton | Polyanion/polycation multilayer film for DNA immobilization |
US20030138842A1 (en) | 2001-06-21 | 2003-07-24 | Michael Seul | Directed assembly of functional heterostructures |
US20030129296A1 (en) | 2001-07-17 | 2003-07-10 | David Kelso | Film-immobilized capture particles |
US20030022370A1 (en) | 2001-07-27 | 2003-01-30 | Rocco Casagrande | Magnetic immobilization of cells |
US20030040129A1 (en) | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
US6503680B1 (en) | 2001-08-29 | 2003-01-07 | Xerox Corporation | Latex processes |
US20030062422A1 (en) | 2001-09-10 | 2003-04-03 | Fateley William G. | System and method for encoded spatio-spectral information processing |
US7195913B2 (en) | 2001-10-05 | 2007-03-27 | Surmodics, Inc. | Randomly ordered arrays and methods of making and using |
US20030148335A1 (en) | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
US20040002073A1 (en) | 2001-10-15 | 2004-01-01 | Li Alice Xiang | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US20030082487A1 (en) | 2001-10-29 | 2003-05-01 | Robert Burgess | Three dimensional printing using photo-activated building materials |
US20030182068A1 (en) | 2001-10-30 | 2003-09-25 | Battersby Bronwyn J. | Device and methods for directed synthesis of chemical libraries |
US6838289B2 (en) | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US20030134326A1 (en) | 2001-12-21 | 2003-07-17 | Hansen Mark R. | Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences |
US20030082587A1 (en) | 2001-12-28 | 2003-05-01 | Michael Seul | Arrays of microparticles and methods of preparation thereof |
US20080123089A1 (en) | 2001-12-28 | 2008-05-29 | Michael Seul | Quality control method for making a biochip displaying an encoded bead array |
US20050048570A1 (en) | 2001-12-28 | 2005-03-03 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten | Structured-functional bonding matrices for biomolecules |
US7335153B2 (en) | 2001-12-28 | 2008-02-26 | Bio Array Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
US20030152931A1 (en) | 2002-02-11 | 2003-08-14 | Chung-Fan Chiou | Nucleic acid detection device and method utilizing the same |
US20030177036A1 (en) | 2002-03-12 | 2003-09-18 | Colin Corporation | Statistical-medical-information supplying method and apparatus |
US20030186220A1 (en) | 2002-03-28 | 2003-10-02 | Jizhong Zhou | Detecting microorganisms using whole genomic DNA or RNA microarray |
US6730515B2 (en) | 2002-06-11 | 2004-05-04 | Eastman Kodak Company | Micro-array calibration means |
EP1394270B1 (en) | 2002-08-22 | 2008-03-12 | BioArray Solutions Ltd. | Methods of use of Molecular constructs for detection of biochemical reactions |
US7041453B2 (en) | 2002-08-22 | 2006-05-09 | Bioarray Solutions Ltd. | Molecular constructs and methods of use for detection of biochemical reactions |
US7320864B2 (en) | 2002-08-22 | 2008-01-22 | Bioarray Solutions Ltd. | Methods of using molecular constructs for detection of biochemical reactions |
US7306918B2 (en) | 2002-09-09 | 2007-12-11 | Bioarray Solutions Ltd. | Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads |
US7425416B2 (en) | 2002-09-09 | 2008-09-16 | Bio Array Solutions Ltd. | Genetic analysis and authentication |
US7157228B2 (en) | 2002-09-09 | 2007-01-02 | Bioarray Solutions Ltd. | Genetic analysis and authentication |
US7344841B2 (en) | 2002-09-09 | 2008-03-18 | Bioarray Solutions Ltd. | Real-time monitoring of nucleic acid target-identifying signals |
US20040048259A1 (en) | 2002-09-09 | 2004-03-11 | Ghazala Hashmi | Genetic analysis and authentication |
US20040093238A1 (en) | 2002-11-08 | 2004-05-13 | Deakter Daniel R. | System and process for matching patients with clinical medical trials |
US7940968B2 (en) | 2002-11-15 | 2011-05-10 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
US7141217B2 (en) | 2002-12-05 | 2006-11-28 | Uop Llc | Elevated pressure apparatus and method for generating a plurality of isolated effluents |
US6869798B2 (en) | 2003-04-17 | 2005-03-22 | Clinical Diagnostics Solutions, Inc. | Lytic reagent composition for leukocyte differential analysis |
US20040229269A1 (en) | 2003-05-15 | 2004-11-18 | Ghazala Hashmi | Hybridization-mediated analysis of polymorphisms |
US7732575B2 (en) | 2003-09-22 | 2010-06-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US7595279B2 (en) | 2003-09-22 | 2009-09-29 | Bioarray Solutions Ltd. | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
US20050143928A1 (en) | 2003-10-03 | 2005-06-30 | Cira Discovery Sciences, Inc. | Method and apparatus for discovering patterns in binary or categorical data |
US20060035240A1 (en) | 2003-10-28 | 2006-02-16 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
US7582488B2 (en) | 2003-10-28 | 2009-09-01 | Bio Array Solutions Ltd. | Gel-shell beads with adsorbed or bound biomolecules |
US7049077B2 (en) | 2003-10-29 | 2006-05-23 | Bioarray Solutions Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA |
US7790380B2 (en) | 2003-10-29 | 2010-09-07 | Bioarray Solutions, Ltd. | Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments |
US20050112585A1 (en) | 2003-11-21 | 2005-05-26 | Dominic Zichi | Method for adjusting the quantification range of individual analytes in a multiplexed assay |
US20080261205A1 (en) | 2004-02-06 | 2008-10-23 | Canadian Blood Services | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes |
EP1564306B1 (en) | 2004-02-17 | 2013-08-07 | Affymetrix, Inc. | Methods for fragmenting and labeling DNA |
US20080020374A1 (en) | 2004-02-20 | 2008-01-24 | Greene Mark I | Reagents, Kits and Methods for Immunodetection of Epitopes on Molecules |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US7501253B2 (en) | 2004-09-21 | 2009-03-10 | The Board Of Trustees Of The Leland Stanford Junior University | DNA fingerprinting using a branch migration assay |
US20060275799A1 (en) | 2005-06-01 | 2006-12-07 | Sukanta Banerjee | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20070231810A1 (en) | 2005-10-07 | 2007-10-04 | Todd Alison V | Multicomponent nucleic acid enzymes and methods for their use |
US20070243534A1 (en) | 2006-04-12 | 2007-10-18 | Michael Seul | Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase |
WO2010026038A1 (en) | 2008-09-02 | 2010-03-11 | Siemens Aktiengesellschaft | Busbar and busbar system in flat profile design comprising a plurality of partial conductor rails having recesses at the narrow side for latching of contact spring elements |
US20100062518A1 (en) | 2008-09-09 | 2010-03-11 | Sukanta Banerjee | Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample |
WO2010098765A1 (en) | 2009-02-27 | 2010-09-02 | Leslie Cifuentes French | Dispenser and applicator that bring reactive substances into contact with each other at the time of use |
Non-Patent Citations (370)
Title |
---|
A. Hatch, et al., "Diffusion Immunoassay in Polyacrylamide Hydrogels". Micro Total Analysis Systems, pp. 571-572 (2001). |
Aho et al., "Efficient String Matching: An Aid to Bibliographic Search". Communications of the ACM, vol. 18, No. 6, pp. 333-340 (Jun. 1975). |
Albergo et al., "Solvent effects on the thermodynamics of double-helix formation in (dG-sC) 3". Biochemistry, vol. 20, No. 6: 1413-1418 (1981). |
Albrecht et al, "Probing the role of multicellular organization in three-dimensional microenvironments". Nature Methods, vol. 3, No. 5, pp. 369-375 (May 2006). |
Albrecht et al., "Photo and electropatterning of hydrogel-encapsulated living cell arrays", Lab on a Chip, vol. 5, Issue 1, pp. 111-118 (2004). |
Alford, R. L., "DNA Analysis in forensics, disease and animal/plant identification". Current Opinions in Biotechnology, vol. 5(1), pp. 29-33 (1994). |
Al-Soud, W. A., "Purification and Characterization of PCR-Inhibitory Components in Blood Cells". Journal of Clinical Microbiology, vol. 39, No. 2, pp. 485-493 (Feb. 2001). |
Al-Soud, W. A., et al., "Identification and characterization of immunoglobulin G in blood as a major inhibitor of diagnostic PCR". Journal of Clinical Microbiology, vol. 38, No. 1, pp. 345-350 (Jan 2000). |
Ambruso, D. R., et al., "Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy", Transfusion, vol. 27, No. 1, 1987, pp. 94-98. |
Arenko, et al., "Protein microchips: Use for immunoassay and enzymatic reactions". Analytical Biochemistry, vol. 278, pp. 123-131 (2000). |
Armstrong et al., "Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping" Cytometry. vol. 40:102-108 (2000). |
Assie et al., Correlation between low/high affinity ratios for 5-HT Receptors and Intrinsic Activity, European Journal of Pharmacology, vol. 386, pp. 97-103 (1999). |
B.-Y. Ha et al., "Counterion-Mediated Attraction between Two Like-Charged Rods," Physical Review Letters, Aug. 18, 1997, vol. 79, No. 7, pp. 1289-1292. |
Bakewell et al., "Characterization of the dielectrophoretic movement of DNA in micro-fabricated structures", Institute of Physics Conference Series (1999) Electrostatics (1999). |
Balass et al. "Recovery of high-affinity phage from a Nitrostretavidin matrix in phage-display technology". Analytical Biochemistry. vol. 243: 264-269 (1996). |
Baldwin, et al., "Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase". Nature, vol. 44, pp. 2403-2404 (1998). |
Bandeira-Melo, C., et al., "EliCell: A gel-phase dual antibody capture and detection assay to measure cytokine release from eosinophils". Journal of Immunological Methods, vol. 244, pp. 105-115 (2000). |
Bao, Y. P., et al., "Detection of Protein Analytes via Nanoparticle-Based Bio Bar Code Technology". Anal. Chem., vol. 78, pp. 2055-2059 (2006). |
Barany, Francis, "Genetic Disease Detection and DNA Amplification using Cloned Thermostable Ligase". Proceedings of the National Academy of Sciences of the United States of America, vol. 88, pp. 189-193 (Jan. 1991). |
Barnard et al. "A fibre-optic chemical sensor with descrete sensing sites". Nature, vol. 353:338-340 (1991). |
Basu, S., et al., "Synthesis and Characterization of a Peptide Nucleic Acid Conjugated to a D-Peptide Analog of Insulin-like Growth Factor 1 for Increased Cellular Uptake". Bioconjugate Chem, vol. 8, No. 4, pp. 481-488 (1997). |
Battersby et al., "Toward Larger Chemical Libraries: Encoding with Fluorescent Colloids in Combinatorial Chemistry". J. Amer Chem Soc, vol. 122, pp. 2138-2139 (2000). |
Baumgarth N. et al., A practical approach to multicolor flow cytometry for immunophenotyping, J. Immunological Methods, 2000, pp. 77-97, vol. 243. |
Bavykin, S.G., et al., "Portable system for microbial sample preparation and oligonucleotide microarray analysis". Appl. Environmental Microbiol. 67(2), 922-928 (2001). |
Beatty et al. "Probability of Finding HLA-mismatched Related or Unrelated Marrow or Cord Blood Donors", Human Immunology, 2001, vol. 61, pp. 834-840. |
Beebe et al., "Functional Hydrogel structures for autonomous flow control inside microfluidic channels". Nature, vol. 404, No. 6778, pp. 588-590 (Apr. 6, 2000). |
Beiboer, S. W., et al., "Rapid genotyping of blood group antigens by multiplex polymerase chain reaction and DNA microarray hybridization" 45 Transfusion 667-679 (2005). |
Bennett, P. R., et al., "Prenatal Determination of Fetal RhD Type by DNA Amplification". The New England Journal of Medicine, vol. 329, No. 9, pp. 607-610 (Aug. 26, 1993). |
Bernard, Philip S., "Homogenous Multiplex Genotyping of Hemochromatasis Mutations with Fluorescent Hybridization Probes". American Journal of Pthology, vol. 153, No. 4, pp. 1055-1061 (1998). |
Bessetti, J., "An introduction to PCT Inhibitors". Profiles in DNA-PCR Inhibition, pp. 9-10 (Mar. 2007). |
Bickel, P. J., "Discussion of the Evaluation of Forensic DNA Evidence". Proc. Natl. Acad. Sci., vol. 94, p. 5497 (May 1997). |
Blaaderen, et al., "Synthesis and Characterization of Colloidal Dispersions of Fluorescent, Monodisperse Silica Spheres". Langmuir, vol. 8, No. 2, pp. 2921-2931 (1992). |
Bonnet, G., et al., "Thermodynamic basis of the enhanced specificity of structured DNA probes," Proc. Natl. Acad. Science, USA, vol. 96, pp. 6171-6176, May 1999. |
Bortolin, S. et al. "Analytical validation of the tag-it high-throughput microsphere-based universal arrray genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms" Clinical Chemistry, vol. 50 (11), pp. 2028-2036 (Sep. 13, 2004). |
Bos et al., "Controlled release of pharmaceutical protein from hydrogels". Business Briefing: Pharmatech, pp. 184-187 (2002). |
Boyce, et al. "Peptidosteroidal Receptors for Opioid Peptides. Sequence-Selective Binding Using a Synthetic Receptor Library". J. Am. Chem. Soc., vol. 116, No. 17, pp. 7955-7956 (1994). |
Boyd et al. "Tosyl Chloride activation of a rayon/polyester cloth for protein immobilization", Biotechnology Techniques, Apr. 1993, vol. 7, 4:277-282. |
Braeckmans et al., "Encoding microcarriers by spatial selective photobleaching", 2003, Nature materials, vol. 2, No. 3, pp. 169-173. * |
Braga et at, "Hydrophobic Polymer Modification with Ionic Reagents: Polysterene Staining with Water-Soluble Dyes". Langmuir, vol. 19, No. 18, pp. 7580-7586 (2003). |
Breslauer, K.J. et al., "Predicting DNA duplex stability from the base sequence". PNAS USA, vol. 83, pp. 3746-3750 (1986). |
Brick, et al., "Formation of Colloidal Dispersions of Organic Materials in Aqueous Media by Solvent Shifting". Langmuir, vol. 19, No. 16, pp. 6367-6380 (Jan. 31, 2003). |
Broude et al., "Multiplex allele-specific target amplification based on PCR suppression". PNAS. vol. 98, No. 1, pp. 206-211 (2001). |
Brown, Patrick O., et al., "Exploring the new world of the genome with DNA microarrays". Nature Genetics Supplement, vol. 21, pp. 33-37 (Jan. 1999). |
Buck et al., "Design Strategies and Performance of Custom DNA Sequence Primers". BioTechniques, vol. 27, pp. 528-536 (Sep. 1999). |
Bunce et al., "Phototyping: Comprehensive DNA Typing for HLA-A, B, C, DRB1, DRB2, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)". Tissue Antigens, vol. 46, No. 5, pp. 355-367 (Nov. 1995). |
Bunce, M., et al., "Comprehensive serologically equivalent DNA typing for HLA-A by PCR using sequence specific primers (PCR-SSP)", Tissue Anitigens 45 : 81-90 (1995). |
Burbulis, I, et al., "Using protein-DNA chimeras to detect and count small numbers of molecules". Nature Methods, vol. 2, No. 1, pp. 31-37 (Jan. 2005). |
Cai et al., "Flow cytometry-based minisequencing: A new platform for high-throughput single-nucleotide polymorphism scoring", Genomics 66:135-143 (2000). |
Campbell, C. J., et al., "Cell Interaction Microarray for Blood Phenotyping". Analytical Chemistry, vol. 78, pp. 1930-1938 (2006). |
Campian et al. Colored and fluorescent solid supports. Innovation and Perspectives in Solid Phase Synthesis. Ed: E. Birmingham (Mayflower, London), pp. 469-474 (1994). |
Cao et al., "High and intermediate resolution DNA typing systems for class I HLA-A, B, C genes by hybridization with sequence-specific oligonnucleotide probes (SSOP)", Rev Immunogenetics 1:177-208 (1999). |
Cao et al., "Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection" , Science 197:1536-1539 (2002). |
Caruso et al., "Magnetic Core-Shell Particles: Preparation of Magnetite Multilayers on Polymer Latex Microspheres". Advanced materials, vol. 11, No. 11, pp. 950-953 (1999). |
Caruso, et al., "Magnetic Nanocomposite Particles and Hollow Spheres Constructed by a Sequential Layering Approach". Chem Mater, vol. 13, No. 1, pp. 109-116 (2001). |
Caruso. "Nanoengineering of Particle Surfaces". Advanced Materials, vol. 12, No. 1, pp. 11-22 (2001). |
Casnellie JE, et al., "Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line". Proc natl Sci USA, vol. 79, No. 2, pp. 282-286 (1982). |
Chalmers, et al., "An instrument to determine the magnetophoretic mobility of labeled, biological cells and paramagnetic particles". Journal of Magnetism and Magnetic Materials, vol. 194, pp. 231-241 (1999). |
Chan et al. The Bipohysics of DNA Hybridization with Immobilized Oligonucleotide Probes. Biophysical Journal 69: pp. 2243-2255 (1995). |
Chang, et al., "New Approach to Produce monosized Polymer Microcapsules by the Solute Co-diffusion Method". Langmuir, vol. 17, No. 18, pp. 5435-5439 (2001). |
Chaudhry et al., "Reactivity of human apurinic/apyrimidinic endonucleoase and Escheria coli exonucleonase III with bistranded abasic sites in DNA". The Journal of Biological Chemisty., vol. 272: 15650-15655 (1997). |
Chee, M. et al., "Accessing genetic information with high-density DNA arrays". Science, vol. 274, pp. 610-613 (1996). |
Chen et al., "A Microsphere-Based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension", Genome Research, Cold Spring Harbor Laboratory Press 10:549-557 (2000). |
Chen, YX, et al., "Deletion of arginine codon 229 in the Rhce gene alters e and f but not c antigen expression". vol. 44, No. 3, pp. 391-398 (Mar. 2004). |
Cheng, et al., "A Synthetic peptide derived from p34cdc2 is a Specific and Efficient Substrate of SRC-Family Tyrosine Kinases". J Biol Chem, pp. 9248-9256. vol. 267, No. 13 (1992). |
Cherepinsky, Vera, "On mathematical aspects of genomic analysis", Ph.D. Thesis, published Mar. 2004. |
Cheung, V. G., et al., "Making and Reading Microarrays". vol. 21, pp. 15-19 (Jan. 1999). |
Choi, et al., "An on-chip magnetic separator using spiral electromagnets with semi-encapsulated permalloy". Biosensors & Bioelectronics, vol. 16, pp. 409-416 (2001). |
Clerc, P., et al., "Advanced deep reactive ion etching: a versatile tool for microelectromechanical systems". J. Micromech Microeng, vol. 8, No. 4, pp. 272-278 (Dec. 1998). |
Coffer et al., "Characterization of Quanum-Confined CdS Nanocrystallites Stabilized by Deoxyribonucleic Acid (DNA)" Nanotechnology, 1992 3:69-75. |
Colombie, et al., "Role of Mixed Anionic-Nonionic Systems of Surfactants in the Emulsion Polymerization of Styrene: Effect on Particle Nucleation". Macromolocules, vol. 33, No. 20, pp. 7283-7291 (2000). |
Cosgrove et al. "A Small-angle neutron scattering study of the structure of gelatin at the surface of polystyrene latex particles". Langmuir. vol. 14:5376-5382 (1998). |
Coyne et al., "Assymetric PCR for ssDNA Production", Molecular Biology Techniques Manual. Third Edition. Jan. 1994, Feb. 2001; http://www.mcb.uct.ac.za/pcrcond.htm. |
Crisp, M., et al., "Preparation of Nanoparticle Coatings on Surfaces of Complex Geometry". Nano Letters, vol. 3, No. 2, pp. 173-177 (2003). |
Cronin M.T. et al., "Cystic Fibrosis Mutation Detection by Hybridization to Light-Generated DNA Probe Arrays," Human Mutation, John Wiley & Sons, Inc., US, vol. 7, No. 3, pp. 244-255 (Jan. 1996). |
Cruse et al., "Illustrated Dictionary of Immunology". Boca Raton: CRC Press, p. 512 (2003). |
Dai-Wu Seol, et al., "Signaling Events Triggered by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL): Caspase-8 is Required for TRAIL-Induced Apoptosis". Cancer Research, vol. 61, pp. 1138-1143 (2001). |
Dasgupta, et al., "Flow of multiple fluids in a smalll dimension". Analytical Chemistry, vol. 74, No. 7, pp. 208-213 (2002). |
De Farias, P., et al., Investigation of red blood cell antigens with highly fluorescent and stable semiconductor quantum dots, J. Bimedical Optics, 2005, pp. 1-4, vol. 10(4). |
Decher, G., "Fuzzy Nanoassemblies: Towared Layered Polymeric Multicomposites". Science, vol. 277, pp. 1232-1237 (Aug. 29, 1997). |
Denkov et al. "Mechanism of Formation of Two-Dimensional Crystals from Latex Particles on Substrates," langmuir, 1992, pp. 3183-3190, vol. 8. |
Denomme, G. A., et al., "High throughput multiplex single-nucloetide polymorphism analysis for red cell and platelet antigen genotypes". Transfusion, vol. 45, pp. 660-666 (May 2005). |
Ding et al., "Direct molecular haplotyping of long-range genomic DNA with M1-PCR", Jun. 2003, vol. 100, 13: 7449-7453. |
Du et al., "Sensitivity and Specificity of Metal Surface-Immobilized," Molecular Beacon, Biosensors; JACS 2005, vol. 127, No. 21, pp. 7932-7940. |
Duggan, David J., et al., "Expression profiling using cDNA microarrays". Nature Genetics Supplement, vol. 21, pp. 10-14 (Jan. 1999). |
Dunbar SA et al. "Application of the luminex LabMAP in rapid screening for mutations in the cystic fibrosis transmembrane conductance regulator gene: A pilot study" Clin Chem Sep. 2000; 46(9): 1498-500. with Abstract data, pp. 1 and 2. |
Duquesnoy HLA Matchmaker: A Molecularly Based Algorithm for Histocompatibility Determination. I. Description of the Algorithm. Human Immunology, vol. 63, pp. 339-352 (2002). |
Dziennik, S. R., et al., "Nondiffusive mechanisms enhance protein uptake rates in ion exchange particles". PNAS, vol. 100, No. 2, pp. 420-425 (2003). |
Easteal, S. "DNA Fingerprinting by PCR Amplification of HLA Genes". DNA and Criminal Justice; Human Genetics Group, John Curtin School of Medical Research, pp. 121-127 (1991). |
Egner et al. "Tagging in combinatorial chemistry: the use of coloured and fluorescent beads". Chem. Commun. pp. 735-736 (1997). |
Elaissari et al., "Hydrophilic and cationic latex particles for the specific extraction of nucleic acids". J. Biomater, Sci Polymer Edn, vol. 10, pp. 403-420 (1999). |
Erdogan et al., "Detection of mitochondrial single nucleotide polymorphisms using a primer elongation reaction on oligonucleotide microarrays", Nucleic Acid Research, 29 : 1-7 (2001). |
Ericsson, O., et al., "A dual-tag microarray platform for high-performance nucleic acid and protein analyses". Nucleic Acids Research, vol. 36, No. 8 e45, pp. 1-9 (2008). |
Erlich, et al., "HLA DNA Typing and Transplantation", Immunity, 14: 347-356 (2001). |
Fan et al., "Parallel Genotyping of Human SNPs Using Generic High-density Oligonucleotide Tag Arrays", Genome Research, vol. 10, pp. 853-860 (2000). |
Fatin-Rouge, N., et al., "Diffusion and Partitioning of Solutes in Agarose Hydrogels: The Relative Influence of Electrostatic and Specific Interactions", J. Phys. Chem. B., vol. 107, pp. 12126-12137 (2003). |
Ferguson et al., "High-Density Fiber-Optic DNA Random Microsphere Array". Anal. Chem, vol. 72, pp. 5618-5624 (2000). |
Filipovich et al., "Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program", Blood, vol. 97, No. 6, pp. 1598-1603 (2001). |
Finkel, et al. "Barcoding the Microworld". Analytical Chemistry, pp. 353-359 (Oct. 1, 2004). |
Fitch, J.P. et al., "Rapid Development of Nucleic Acid Diagnostics", Proceedings of the IEEE 90 (11): 1708-1720 (Nov. 2002). |
Fluorescent Microspheres (Tech. Note #19). Bangs Laboratories (1997). |
Fodor, S,, et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis". Research Article (Authors are at the Affymax Research Institute, 3180 Porter Drive, Palo Alto, CA 94304), pp. 767-773 (Feb. 15, 1991). |
Fowke, Keith R., et al. "Genetic analysis of human DNA recovered from minute amounts of serum or plasma". Journal of Immunological Methods, vol. 80, pp. 45-51 (1995). |
Frengen, Jomar, et al., "Demonstration and Minimization of Serum Interference in Flow Cytometric Two-Site Immunoassays". Clinical Chemistry, vol. 40, No. 3, pp. 420-425 (1994). |
Fuh et al. Single Fibre Optic Fluorescence pH Probe. Analyst, 112:1159-1163 (1987). |
Fuh et al., "A Method for Determination of Particle Magnetic Susceptibility with Analytical Magnetapheresis". Anal. Chem, vol. 72, pp. 3590-3595 (2000). |
Fukuda et al., "Noncontact manipulation of DNA molecule 1. Transportation of DNA molecule by dielectric force". Nippon Kikai Gakkai Ronbunshu, vol. 62: 2765-2772 (1996). |
Fulton et al. "Advanced multiplexed analysis with the FlowMetrix system". Clinical Chemistry, vol. 43:9, pp. 1749-1756 (1997). |
Gahan, P. B., "Circulating Nucleic Acid in Plasma and Serum: Diagnosis and Prognosis in Cancer". Oncology, vol. 32, No. 6, pp. 20-22 (Oct. 2008); Weekly news updates on www.cli-online.com. |
Garber, K. "More SNPs on the Way". Science, vol. 281, No. 5384, pp. 1788-1790 (Sep. 18, 1998). |
Gates, et al., "Photonic Crystals that can be Addressed with an External Magnetic Field". Adv Mater, vol. 13, No. 21, pp. 1605-1608 (2001). |
Gelfi, C., et al., "Investigation of the Properties of Novel Acrylamido Monomers by Capilary Zone Electrophoresis", Journal of Chromatography, vol. 608, pp. 333-341 (1992). |
Gerlach. Human Lymphocyte Antigen Molecular Typing. Archives of Pathology & Laboratory Medicine. vol. 126, pp. 281-284 (2002). |
Ghazaly, et al., "Synthesis and Characterization of a Macromonomer Crosslinker". Journal of Applied Polymer Science, vol. 77, pp. 1362-1368 (2000). |
Ghosh et al. "Covalent attachement of oligonucleotides to solid supports". Nucleic Acids Research. vol. 16, No. 13; pp. 5363-5371 (1987). |
Ghosh, P., et al., "A Simple Lithographic Approach for Preparing Patterned, Micron-Scale Corrals for Controlling Cell Growth". Angew. Chem. Int. Ed., vol. 38, No. 11, pp. 1592-1595 (1999). |
Giersig et al. Formation of ordered two-dimensional gold colloid lattices by electrophoretic deposition. J. Phys. Chem., vol. 97: 6334-6336 (Apr. 29, 1993). |
Giorgi, R., et al., "Nanotechnologies for Conservation of Cultural Heritage: Paper and Canvas Deacidification". Langmuir, vol. 18, pp. 8198-8203 (2002). |
Good, L., et al., "Bactericidal antisense effects of peptide-DNA conjugates". Nature Biotechnology, vol. 19, pp. 360-364 (2001). |
Goodey et al., "Development of multianalyte sensor arrays composed of chemically derivatized polymeric microspheres localized in micromachined cavitites". Journal of American Chemical Society, vol. 123, pp. 2559-2570 (2001). |
Graf et al., "A general method to coat colloidal particles with silica". Langmuir, vol. 19, pp. 6693-6700 (2003). |
Grazia et al. In-vivo biomedical monitoring by fiber-optic system. Journal of Lightwave Technology. 13, 1396-1406 (1995). |
Grondahl, et al., "Encoding Combinatorial Libraries: A Novel Application of Fluorescent Silica Colloids". Langmuir, vol. 16, No. 25, pp. 9709-9715 (2000). |
Gruttner, et al., "New types of silica-fortified magnetic nanoparticles as tools for molecular biology applications". Journal of Magnetism and Magnetic Materials, vol. 94, pp. 8-15 (1999), |
Gubin et al., "Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family", Blood, Oct. 1, 2000, vol. 96, No. 7, pp. 2621-2627. |
Gullberg, M., et al., "Cytokine detection by antibody-based proximity ligation". PNAS, vol. 101, No. 22, pp. 8420-8424 (Jun. 2004). |
Guo, Zhen et al. "Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system". Genome Research; vol. 12, No. 3, pp. 447-457 (Mar. 2002). |
Guo, Zhen, "Direct fluorescence analysis of genetic polymorphisms . . . oligonucleotide arrays on glass supports". Nucleic Acids Research, Jul. 1994, Oxford Univ Press, pp. 5456-5465. |
Gupta et al. ("Hydrogels: from controlled release to pH-responsive drug delivery" Drug Discov Today. May 15, 2002;7(10):569-79. |
Gustafsdottir, S. M., "In vitro analysis of DNA—protein interactions by proximity ligation". PNAS, vol. 104, No. 9, pp. 3067-3072 (Feb. 2007). |
Haab et al. Single Molecule Fluorescence Burst Detection of DNA Fragments Separated by Capillary Electrophoresis. Analytical Chemistry, vol. 67 (No. 18) : 3253-3256 (1995). |
Hacis et al., "Resequencing and mutational analysis using oligonucleotide microarrays", Nature America; 21 : 42-47 (1999). |
Hakala, H., et al. "Simultaneous detection of several oligonucleotides by time-resolved fluorometry: the use of a mixture of categorized microparticles in a sandwich type mixed-phase hybridization assay". Nucleic Acids Research, vol. 26, pp. 5581-5585 (1998). |
Hashimi et al., "A Flexible Array format for large-scale, rapid blood group DNA typing". Transfusion, Published Online Apr. 6, 2004, vol. 45, Issue 5, pp. 680-688 (May 2005). |
Hashmi, G., et al, "Determination of 24 minor red blood cell antigens for more than 2000 blood donors by high-throughput DNA analysis". Transfusion, vol. 47, No. 4, pp. 736-747 (Apr. 2007). |
Heinrich, et al., "Interleukin-6-type Cytokine Signaling through the gp 130/Jak/STAT pathway". Biochem J, vol. 334, pp. 297-314 (1998). |
Helgesen, et al., "Aggregation of magnetic microspheres: experiements and simulations". Physical Review Letters, vol. 61, No. 15, pp. 1736-1739 (1998). |
Helmuth, R., et al., "HLA-DQ Allele and Genotype Frequencies in Various Human Populations, Determined by Using Enzymatic Amplification and Oligonucleotide Probes". Am. J. Hum. Genet, vol. 47, pp. 515-523 (1990). |
Hermanson, G. T., "Nucleic Acid and Oligonucleotide Modification and Conjugation". Bioconjugate Techniques, Academic Press, Chapter 17, pp. 639-671 (Jan. 15, 1996). |
Hermanson, Greg T., "Bioconjugate Techniques", Bioconjugate Techniques; Academic Press, San Diego, 430-33, (1996). |
Hermanson, Greg T., "Zero Length Cross-Linkers"; Bioconjugate Techniques; Academic Press, pp. 170-176 (1996). |
Hiller, J., et al., "Reversibly erasable nanoporous anti-reflection coatings from polyelectrolyte multilayers". Nature Materials, vol. 1, pp. 59-63 (Sep. 2002). |
Hirata, H., et al., "Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis". J, Exp. Med., vol. 187, No. 4, pp. 587-600 (1998). |
Hizume, et al., "Tandem repeat DNA localizing on the proximal DAPI bands of chromosomes in Larix, pinaceae". Genome, vol. 45, pp. 777-783 (2002). |
Holtz, J., et al., "Intelligent Polymerized Crystalline Colloidal Array: Novel Sensor Materials", Analytical Chemistry, vol. 70, No. 4, pp. 780-791 (1998). |
Houghton. "General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of anitgen-antibody interaction at the level of individual amino acids". Proc. Natl. Avad. Sci. USA. vol. 82:5131-5135 (1985). |
Huff et al., "Technical Milestone: Development of the Logical Observation Identifier Names and Codes (LOINC) Vocabulary". JAIMA, vol. 5, pp. 276-292 (1998). |
Iannone, Marie A., et al., "Multiplexed Single Nucelotide Polymorphism Genotyping by Oligonucleotide Ligation and Flow Cytometry". Cytometry, vol. 39, Issue 2, pp. 131-140 (Feb. 17, 2000). |
Ide et al., "Synthesis and damage specificity of a novel probe for the detection of abasic sites in DNAa". Biochemistry. vol. 32: 8276-8283 (1993). |
Ito, Y., et al., "Patterned Immobilization of Thermoresponsive Polymer", Langmuir, vol. 13, pp. 2756-2759 (1997). |
Iwayama, et al., "Optically Tunable Gelled Photonic Crystal Covering Almost the Entire Visible Light Wavelength Region", Langmuir (2002). |
J.F. Chapman et al., "Working Party of the BCSH: Guidelines for compatibility procedures in blood transfusion laboratories", Transfusion Medicine, vol. 14, pp. 59-73 (2004). |
Jackman, R. J., et al., "Using Elastomeric Membranes as Dry Resists and for Dry Lift-Off", Langmuir, vol. 15, pp. 2973-2984 (1999). |
Jeon, N. L., et al., "Patterned polymer growth on silicon surfaces using microcontact printing and surface-initiated polymerization", Applied Physics Letters, vol. 75, No. 26, pp. 4201-4203 (1999). |
John C. Guatelli et al., "Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication, "Proc. Nat'l Academy of Science USA, vol. 87: pp. 1874-1878 (1990). |
Johnson, K. L., et al., "Surface Energy and the Contact of Elastic Solids". Proceedings of the Royal Society of London, Series A, Mathematical and Physical Sciences, vol. 324, No. 1558, pp. 301-313 (Sep. 8, 1971). |
Jones et al., "Constraint, Optimization, and Hierarchy: Reviewing Stereoscopic Correspondence of Complex Features". Computer Vision and Image Understanding, vol. 65, No. 1, pp. 57-78 (1997). |
Jones et al., "Dielectrophoretic liquid actuation and nanodroplet formation", Journal of Applied Physics, vol. 89, No. 2, pp. 1441-1448 (Jan. 15, 2001). |
Kakabakos et al. "Immobilization of Immunoglobulins onto Surface-treated and Untreated Polystyrene Beads for Radioimmunoassays" Clin. Chem. 36 (1990), 492-496. |
Kalinina, O., et al., "A core-shell Approach to Producing 3D Polymer Nanocomposites", Macromolecules, vol. 32, pp. 4122-4129 (1999). |
Kamholz, et al., "Optical measurement of transverse molecular diffusion in a microchannel". Biophysical Journal, vol. 80, pp. 1967-1972 (2001). |
Kamm, R. C., et al. "Nucleic Acid Concentrations in Normal Human Plasma". Clinical Chemistry, vol. 18, pp. 519-522 (1972). |
Kandimalla et al., "Cyclicons" as Hybridization-Based Fluorescent Primer-Probes: Bioorganic & Medicinal Chemistry 8 (2000) 1911 to 1916. |
Kelly, J.J., et al., "Radical-generating coordination complexes as tools for rapid and effective fragmentation and fluorescent labeling of nucleic acids for microchip hybridization". Analytical Biochemisty, vol. 311, No. 2, pp. 103-118 (Dec. 15, 2002). |
Kim, E., et al., "Polymer microstructures formed by moulding in capillaries", Nature, vol. 376, pp. 581-584 (1995). |
Klintschar, et al., "Genetic variation at the STR loci D12S391 and CSF1PO in four populations from Austria, Italy, Egypt and Yemen". Forensic Sci. Int. vol. 97:37-45 (1998). |
Knipper, et al., Accession No. AF221125.1.1 on Electronic Database at NCBI (Feb. 16, 2000). |
Koch et al., "PNA-Peptide Chimerae". Tetrahedron Letters, vol. 36, pp. 6933-6936 (1995). |
Koh, et al., "Molding of Hydrogel Microstructures to Create Multiphenotype Cell Microarrays". Analytical Chemistry (2003). |
Koh, et al., "Poly(ethylene glycol) Hydrogel Microstructures Encapsulating Living Cells". Langmuir, vol. 18, pp. 2459-2462 (2002). |
Kolch. "Meaningful Relationships: The Regulation of the Ras/Raf/MEK/ERK pathway by protein interactions". Biochem J, vol. 351, pp. 289-305 (2000). |
Kotov, N., et al., "Layer-by-Layer Self-Assembly of Polyelectrolyte-Semicondictor Nanoparticle Composite Films". J. Phy Chem, vol. 99, pp. 13065-13069 (1995). |
Krausa et al. "A Comprehensive PCR-ssP typing system for identification of HLA-A locus alleles", Tissue Antigens, 47 (3) : 237-244 (1996). |
Krsko, P., et al., "Electron-Beam Surface Patterned Poly(ethylene glycol) Microhydrogels". Langmuir, vol. 19, pp. 5618-5625 (2003). |
Krutzik P.O. et al., "Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signal profiling". Nature Methods, vol. 3, No. 5, pp. 361-368 (2006). |
Kubo et al., "A Novel Sensitive and specific assay for abasic sites, the most commonly produced DNA lesion". Biochemistry, vol. 13:3703-3708 (1992). |
Kumacheva, E., et al., "Three-dimensional Arrays in Polymer Nanocompositites", Advanced Materials, vol. 11, No. 3, pp. 231-234 (1999). |
Kurita-Ochiai, T., et al., "Butyric Acid-Induced T-Cell Apoptosis is Mediated by Caspase-8 and -9 Activation in a Fas-Independent Manner". Clinical and Diagnostic Laboratory Immunology, vol. 8, No. 2, pp. 325-332 (2001). |
Kwoh et al., "Transcription based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format". Proc. Natl. Acad. Sci, vol. 86, pp. 1173-1177 (Feb. 1989). |
LaForge, K. S., et al., "Detection of Single Nucleotide Polymorphisms of the Human Mu Opioid Receptor Gene by Hybridization of Single Nucleotide Extension on Custom Oligonucleotide Gelpad Microchips: Potential in Studies of Addiction". American Journal of Medical Genetics (Neuropsychiatric Genetics), vol. 96, pp. 604-615 (2000). |
Lagerholm et al., "Theory for Ligand Rebinding at Cell Membrane Surfaces," Biophysical Journal (1998), vol. 74, pp. 1215-1228. |
Lamb, D. J., et al., "Modification of Natural and Artificial Polymer Colloids by Topology-Controlled Emulsion Polymerization". Biomacromolecules, vol. 2, No. 2, pp. 518-525 (2001). |
Lander, E. S. "The New Genomics: Global Views of Biology". Sciences, vol. 274, No. 5287, pp. 536-539 (Oct. 25, 1996). |
Lander, E. S., et al., "Array of Hope". Nature Genetics Supplement, Perspective, vol. 21, pp. 3-4, (Jan. 1999). |
Latour, P., et al., "Polymorphic Short Tandem Repeats for Diagnosis of the Charot-Marie-Tooth IA Duplication". Clinical Chemistry, vol. 47, pp. 829-837 (2001). |
Lau, F. Y., et al., "Provision of phenotype-matched blood units: no need for pre-transfusion antibody screening", Haematologica, vol. 86, No. 7, Jul. 2001, pp. 742-748. |
Lee et al. "Quantitation of residual WBCs in filtered blood components by high-throughput, real time kinetic PCR", Blood Components, transfusion, vol. 42, pp. 87-93 (Jan. 2002). |
Lee, et al., "Combination of Insulin-like Growth FActor (IGF)-1 and IGF-Binding Protein-1 Promotes Fibroblast-Embedded Collagen Gel Contraction". Endocrinology, vol. 137, pp. 5278-5283 (1996). |
Lee, H. J., et al., "Fabricating RNA Microarrays with RNA-DNA Surface Ligation Chemistry". Analytical Chemistry, vol. 77, No. 23, pp. 7832-7837 (Dec. 1, 2005). |
Lee, S., et al., "Control of Core-Shell Latex Morphology". Polymer Latexes, ACS Symposium, American Chemical Society, pp. 234-253 (1992). |
Lemieux: "high throughput single nucleotide polymorphism genotyping technology" Current Genomics. vol. 1:301-311 (2000). |
Lhomme et al. "Abasic DNA structure, reactivity and recognition". Biopolymers. vol. 52 : 65-83 (1999). |
Li, A., et al., "Multiplexed analysis of polymorphisms in the HLA gene complex using bead array chips". Tissue Anitigens, vol. 63, pp. 518-528 (2004). |
Liang L., et al., "Preparation of Composite-Crosslinked Poly(N-isopropylacrylamide) Gel Layer and Characteristics of Reverse Hydrophilic-Hydrophobic Surface", Journal of Applied Polymer Science, vol. 72, pp. 1-11 (1999). |
Liang, L., et al., "Temperature-sensitive membranes prepared by UV photopolymerization of N-isoproprylacrylamide on a surface of porous hydrophilic polypropylene membranes", Journal of Membrane Science, vol. 162, pp. 235-246 (1999). |
Liebert, M. R., et al., "Dynamics of the holes in human erythrocyte membrane ghosts". J. Biological Chemistry, vol. 257, No. 19, pp. 11660-11666 (1982). |
Lin et al. "Raman Studies of Bovine Serum Albumin" . Biopolymers 15:203-218 (1976). |
Lindahl et al., "Rate of chain breakage at apurinic sites in double-stranded deoxyribonclueic acid" Biochemistry, vol. 11, No. 19:3618-3623 (1972). |
Lindahl et al., "Rate of depuriniation of native deoxyribonucleic acid". Biochemistry. vol. 11, No. 19: 3610-1617 (1972). |
Lipshutz, R. J., et al., "High Density Synthetic Oligonucleotide Arrays". vol. 21, pp. 20-24 (Jan. 1999). |
Liu, et al., "Development of a Carbon Dioxide-Base Microencapsulation Technique for Aqueous and Ethanol-Based Latexes". Langmuir (2002). |
Liu, V, et al, "Three-Dimensional Photopatterning of Hydrogels Containing Living Cell". Biomedical Microdevices, vol. 4, No. 4, pp. 257-266 (2002). |
Lofas, et al., "Methods for site controlled coupling to carboxymethyldextran surfaces in surface plasmon resonance sensors". Biosensors & Bioelectronics, vol. 10, pp. 813-822 (1995). |
Loomans, E., et al., "Assessment of the functional affinity constant of monoclonal antibodies using an improved enzyme-linked immunosorbent assay". Journal of Immunological Methods, vol. 184, pp. 207-217 (1995). |
Lund et al. Assessment of Methods for Covalent Bonding of Nucleic Acids to Magnetic Beads, Bynabeads, and the Characteristics of the Bound Nucleic Acids in Hybridization Reactions, Nucleic Acids REsearch vol. 16, No. 22, 10861-10880 (1988). |
Luo et al., "Emulsion Copolymerization of Butyl Acrylate with Cationic Monomer Using Interfacial Redox Initiator System". Journal of Polymer Science, vol. 39, pp. 2696-2709 (2001). |
Lvov, Y, et al., "Alernate Assembly of Ordered Multilayers of SiO2 and Other Nanoparticles and Polyions". Langmuir, vol. 13, pp. 6195-6203 (1997). |
MacBeath et al., "Printing proteins as microarrays for high-throughput function determination". Science, vol. 289; pp. 1760-1763 (Sep. 8, 2000). |
MacBeath et al., "Printing proteins as microarrays for high-throughput function determination," Science vol. 289: 1760-1763 (2000). |
Maldonado-Rodriguez et al., "Hybridization of glass-tethered oligonucleotide probes to . . . ", Molecular Biotechnology, vol. 11, No. 1, pp. 1-12 (1999). |
Marras et al., Multiplex detection of single-nucleotide variations using molecular beacons: Genetic Analysis: Biomolecular Engineering 14 (1999) 151-156. |
Marsh, S. G. E., et al., The HLA Facts Book, "HLA Typing at the DNA Level", Academic Press, Chapter 6, pp. 37-39 (2000). |
Martin, M., et al. "A Method for Using Serum or Plasma as a Source of DNA for HLA Typing". Human Immunology, vol. 33, pp. 108-113 (1992). |
Martinell, J. et al., "Three mouse models of human thalassemia", Proc. Natl. Acad. Sci, USA. Aug. 1981, vol. 78, No. 8, pp. 5056-5060 (see especially p. 5057, col. 1, last paragraph, Figure 4, and the legend to Figure 4. |
Maskos, U. et al., "Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation". Nucleic Acids Research, vol. 20, No. 7, pp. 1675-1678 (1992). |
Maskos, U., et al., "Oligonucleotide hybridisations on glass supports: a novel linker for oligonucleoptide synthesis and hybridisation properties of oligonucleotides synthesized in situ". Nucleic Acids Research, vol. 20, No. 7, pp. 1679-1684 (1992). |
Matthews et al., "Biochemistry: A Short Course". New York: John Wiley & Sons, Inc, p. 25(1997). |
Maxam et al., "A new method for sequencing DNA," Proc. Natl. Acad. Sci. USA. vol. 74, No. 2, pp. 560-564, Feb. 1977. |
McCloskey, et al., "Magnetic Cell Separation: Characterization of Magnetophoretic Mobility". Anal. Chem., vol. 75, pp. 6868-6874 (2003). |
McCloskey, et al., "Magnetophoretic Mobilities Correlate to Antibody Binidng Capacities". Cytometry, vol. 40, pp. 307-315 (2000). |
Mei et al. "Genome-wide Detection of Allelic Imbalance Using Human SNPs and High-Density DNA Arrays". Genome Research. vol. 10, pp. 1126-1137 (2000). |
Michael, et al., "Randomly ordered addressable high-density optical ssensor arrays". Anal. Chem, vol. 70, pp. 1242-1248 (1999). |
Micheletto et al., "A simple method for the production of a two-dimensional ordered array of small latex particles". Langmuir, vol. 11, pp. 3333-3336 (1995). |
Moller, E., et al., "The Use of Magnetic Beads Coated with Soluble HLA Class I or Class II Proteins in Antibody Screening and for Specificity Determination of Donor-Reactive Antibodies". Transplantation, vol. 61, No. 10, pp. 1539-1545 (May 27, 1996). |
Moore, et al., "The use of magnetite-doped polymeric microspheres in calibrating cell tracking velocimetry". J. Biochem. Biophys. Methods, vol. 44, pp. 115-130 (2000). |
Morag et al. "Immobilized nitro-avidin and nitro-streptavidin as reusable affinity matrices for application in avidin-biotin technology". Analytical Biochemistry. vol. 243: 257-263 (1996). |
Mori, et al., Computer program to predict liklihood of finding an HLA-matched donor: Methodology, validation, and application. Biology of Blood and Marrow Transplantation, vol. 2, pp. 134-144 (1996). |
Morishima et al., "Microflow system and transportation of DNA molecule by dielectrophoretic force utilizing the conformational transition in the higher order structure of DNA molecule". Proceedings—IEEE Annual International Workshop on Micro Electro Mechanical Systems: An investigation of micro structures, sensors, actuators, machines and robots. Nagoya, Jan. 26-30, 1997. |
Muller et al., "Gene and Haplotype Frequencies for the Loci HLA-A, HLB-B, and HLA-DR Based on Over 13,000 German Blood Donors". Human Immunology, 2003, 64: 137-151. |
Mullis et al. Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction Methods in Enzymology, 1987; vol. 155, pp. 335-350. |
Nagarajan et al., "Identifying Spots in Microarray Images", IEEE Transactions on Nanobioscience, vol. 1, No. 2, pp. 78-84 (Jun. 2002). |
Nagayama et al., "Fabrication of two-dimensional colloidal arrays". Phase Transitions, vol. 45, 185-203 (1993). |
Nam, J., et a., "Colorimetric Bio-Barcode Amplification Assay for Cytokines". Anal. Chem., vol. 77, pp. 6985-6988 (2005). |
Nau et al., "A Command Processor for the Determination of Specificities fro Matrices of Reactions Between Blood Cells and Antisera". Computers and Biomedical Research, vol. 10, pp. 259-269 (1977). |
Nazarenko et al. (2002) Multiplexed quantitiative PCR using self-quenched primers labeled with a single fluorophore. Nucleic Acids Research, 30 (9), e37. |
Niemeyer et al., "DNA-directed Immobilization: Efficient, Reversible, and Site-Selective Surface Binding of Proteins by means of Covalent Stretavidin Conjugates". Analytical Biochemistry, vol. 268, pp. 54-63 (1999). |
Niemeyer et al., "Oligonucleotide-directed self-assembly of proteins: semisynthetic DNA—streptavidin hybrid molecules as connectors for the generation of macroscopic arrays and the construction of supramolecular bioconjugates". Nucleic Acids Research, vol. 22, pp. 5530-5539 (1994). |
Nygren, "Molecular Diagnostics of Infectious Diseases" Royal Institute of Technology Department of Biotechnology, Stockholm 2000, pp. 1-68. |
Ohlmeyer, M. H. J. et al. "Complex Synthetic Chemical Libraries Indexed with Molecular Tags". Proceedings of the National Academy of Sciences, USA, National Academy of Science, Washington DC. vol. 90, Dec. 1, 1993, pp. 10922-10926. |
Okubo et al., "Preparation of micron-size monodisperse polymer particles by seeded polymerization utilizing the dynamic monomer swelling method". Colloid and Polymer Science, vol. 269, No. 3, pp. 222-226 (1991). |
Okubo, and Yamashita. "Thermodynamics for the preparation of micorn-sized, monodispersed highly monomer-‘absorbed’ polymer particles utilizing the dynamic swelling method." Colloids and Surfaces, 1999:153-159. |
Olejnik et al., "Photocleavable biotin phosphoramidite for 5′-end-labeling, purification & phosphorylation of oligonucleotides", Nucleic Acids Research 1996, vol. 24, 2:361-366. |
Oliver, D., et al, "Use of Single Nucleotide Polymorphisms (SNP) and Real-Time Polymerase Chain Reaction for Bone Marrow Engraftment Analysis". Journal of Molecular Diagnostics, vol. 2, No. 4, pp. 202-208 (Nov. 2000). |
Olson et al. "A common langauage for physical mapping of the human genome". Science, vol. 245, pp. 1434-1435 (1989). |
Otero, T. F., et al., "Electrochemically initiated acrylic acid/acrylamide copolymerization", J. Electroanal. Chem., vol. 256, pp. 433-439 (1998). |
Otero, T. F., et al., "Electroinitiated polymerization of acrylamide in DMG: Attempts at an interfacial model", J. Electroanal. Chem., vol. 304, pp. 153-170 (1991). |
Pastinen, et al., "A System for specific, high-throughput genotyping by allele-specific primer extension on microarrays". Genome Res., vol. 10, pp. 1031-1042 (2000). |
Peter, C., et al., "Optical DNA-sensor chip for real-time detection of hybridization events". Fresenius J. Anal. Chem, vol. 371, pp. 120-127 (Jun. 2001); Published online Springer-Verlay 2001. |
Peterson, et al. "Fiber Optic pH probe for physiological use". Anal. Chem. vol. 52, 864-869 (1980). |
Peterson, et al., "Fiber Optic Sensors for Biomedical Applications". Science, vol. 13; pp. 123-127 (1984). |
Peytavi et al., "Correlation between microarray DNA hybridization efficiency and the position of short capture probe on the target nucleic acid". Biotechniques, vol. 39, No. 1, pp. 89-96 (2005). |
Pooga, M., et al., "Cell-Penetrating constructs regulate galanin receptor levels and modify pain transmission in vivo" Nature Biotechnology, vol. 16, pp. 857-861 (1998). |
Pope. "Fiber optic chemical microsensors employing optically active silica microspheres". SPIE, vol. 2388; pp. 245-256 (1995). |
Prati D. et al., DNA Enzyme Immunoassay of the PCR-Amplified HLA-DQ Alpha Gene for Estimating Residual Leukocytes in Filtered Blood Clincial and Diagnostic Laboratory Immunology, Mar. 1995, p. 182-185. |
Pregibon et al, "Magnetically and Biologically Active Bead-Patterned Hydrogels". Langmuir, vol. 22, pp. 5122-5128 (2006). |
Preza, "Phase Estimation using rotational diversity for differential interference contrast microscopy". Dissertation presented to the Washington University, Server Institute of Technology, Department of Electrical Engineering; St. Louis, MO (Aug. 1998). |
Proudinikov et al., "Chemical methods of DNA and RNA fluorescent labeling". Nucleic Acids Research. vol. 24, No. 22: 4535-4542 (1996). |
Proudnikov , D., et al., "Immobilization of DNA in Polyacrimide Gel for the Manufacture of DNA and DNA-Oligonucleotide Microchips", Analytical Biochemistry, vol. 259, pp. 34-41 (1998). |
Quon, R., et al., "Measurement of the Deformation and Adhesion of Rough Solids in Contact". J. Phys. Chem., vol. 103, pp. 5320-5327 (1999). |
Rabbany et al., "Assessment of hetrogeneity in antibody displacement reactions". Anal Chem, vol. 69, pp. 175-182 (1997). |
Radtchecnko et al., "Core-shell structures formed by the solvent-controlled precipitation of luminescent ScTe nanocrystals on latex spheres". Advanced Materials, vol. 13, No. 22, pp. 1684-1687 (2001). |
Radtkey et al., "Rapid, high-fidelity analysis of simple sequence repeats on an electronically active DNA microchip". Nucleic Acids Research, vol. 28, No. 7, p. e17 (2000). |
Ramsay, G., "DNA Chips: State-of-the-Art". Nature Biotechnology, vol. 16, pp. 40-44 (Jan. 1998). |
Reddy et al., "Determination of the Magnetic Susceptibility of Labeled Particles by Video Imaging". Chemical Engineering Science, vol. 51, No. 6, pp. 947-956 (1996). |
Reid M.E., et al., "Novel Dombrock blood group genetic variants . . . ", Blood (ASH Annual Meeting Abstract) 2004, 104: Abstract 383. |
Relogio, A. et al., "Optimization of oligonucleotide-based DNA microarrays", Nucl. Acids Res., vol. 30, e51, pp. 1-10 (2002). |
Richardson et al., "The use of coated paramagnetic particles as a physical label in a magneto-immunassay". Biosensors & Bioelectronics, vol. 16, pp. 989-993 (2001). |
Richardson, et al., "A novel measuring system for the determination of paramagnetic particle lables for use in magneto-immunoassays". Biosensors & Bioelectronics, vol. 16, pp. 1127-1132 (2001). |
Richetti et al., "Two-dimensional aggregations and crystallization of a colloidal suspension of latex spjeres", J. Physique Letter. vol. 45, pp. L-1137 to L-1143 (1984). |
Righetti, P. G., et al., "Electrophoresis gel media: the state of the art", J. Chromatogr B., Biomed Sci Appl, vol. 699, No. 1-2, pp. 63-75 (Oct. 10, 1997). |
Roberts et al. "Patterned magnetic bar array for high-thoughput DNA detection" IEEE Transaction on Magnetics. vol. 40, No. 4: 3006-3008 (2004). |
Rubina et al, "Hydrogel drop microchips with immobilized DNA: properties and methods for large-scale production". Analytical Biochemistry, vol. 325, pp. 92-106 (2004). |
Rudzinski, et al., "pH-sensitive acrylic-based copolymeric hydrogels for the controlled release of a pesticide and a micronutrient". Journal of Applied Polymer Science, vol. 87, pp. 394-403 (2003). |
S. Dubiley et al., "Polymorphism Analysis and Gene Detection by minsequencing on an array of gel immobilized primers." Nucleic Acids Research, 1999;i-vi. vol. 27, No. 16. |
S. Ebel et al. "Very Stable Mismatch Duplexes: Structural and Thermodynamic Studies on G-A Mismatches in DNA" Biochemistry 31:12083-86 (1992). |
Sacchetti, et al. "Efficiency of Two Different Nine-Loci Short Tandem Repeat Systems for DNA Typing Purposes". Clinical Chemistry, vol. 45, No. 2, pp. 178-183 (1999). |
Saito, K., et al., "Detection of Human Serum Tumor Necrosis Factor-alpha in Healthy Donors, Using a Highly Sensitive Immuno-PCR Assay". Clinical Chemistry, vol. 45, No. 5, pp. 665-669 (1999). |
Sambrook et al., "Precipitation with Ethanol or Isopropanol", Concentrating Nucleic Aicds, Molecular Cloning vol. 3, pp. E3-E4 and E.10-E.15 (1989). |
Sano, T, et al., "Immuno-PCR: Very Senisitive Antigen Detection by Means of Specific Antibody-DNA Conjugates". Science, vol. 258, pp. 120-122 (Oct. 2, 1992). |
Santa Lucia, J. Jr., "A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics". PNAS USA, vol. 95, pp. 1460-1465 (1998). |
Schaid et al., "Score Tests for Association between traits and Haplotypes when Linkage Phase is Ambiguous", American Journal of Genetics. vol. 70, pp. 425-434 (2002). |
Schena et al., "Quantitative Monitoring of Gene Expression Patterns with a Complementary DA Microarray". Science, vol. 270, pp. 467-470 (1995). |
Schouten, Jan P., et al., "Relative Quantification of 40 Nucleic Acid Sequences by Multiplex Ligation-Dependent Probe Amplification". Nucleic Acids Research, vol. 30, No. 12, e57 (Jun. 15, 2002). |
Schreiber, G. B., et al., "Increasing Blood Availability by changing Donation Patterns". Transfusion, vol. 43, pp. 591-597 (2003). |
Schreuder et al., "The HLA Dictionary 1999: A Summary of HLA-A, B, C, DRB1/3/4/5, DOB1 alleles and their association with serologically defined HLA-A, B, C, DR and DQ antigens", Tissue Antigens 54 : 409-437 (1999). |
Schumaker, et al., "Mutation Detection by solid phase primer extension", Human Mutation 7:346-354 (1996). |
Schuster et al. "Allele-specific and asymetric polymerase chain reacton amplification in combination: a one step polymerase chain protocol for rapid diagnosis of familial defective apolipoprotein B-100", Anal Biochem. Jul. 1992; 204 (1):22-5). |
Scillian, James J., et al., "Early Detection of Antibodies Against rDNA-Produced HIV Proteins with a Flow Cytometric Assay". Clinical Chemistry, vol. 40, No. 3, pp. 420-425 (1994). |
Scott et al., "Properties of Fluorophores on solid phase resins; Implications for screening, encoding and reaction monitoring". Bioorganic & Medicinal Chemistry Letter, vol. 7, No. 12, pp. 1567-1572 (1997). |
Seeman, P., et al., "Structure of Membrane Holes in Osmotic and Saponin Hemolysis"; The Journal of Cell Biology, vol. 56; pp. 519-527 (1973). |
Sehgal et al. "A method for the high effieiency of water-soluble carbodiimide-mediated amidation". Analytical Biochemistry. vol. 218:87-91 (1994). |
Seltsam, et al., Systematic analysis of the ABO gene diversity within exons 6 and 7 by PCR screening reveals new ABO alleles, Transfusion, vol. 43, pp. 428-439 (2003). |
Sennerfors, T., et al., "Adsorption of Polyelectrolyte-Nanoparticle Systems on Silica: Influence of Ionic Strength". Journal of Colloid and Interface Science, vol. 254, pp. 222-226 (2002). |
Serizawa, T., et al., "Electrostatic Adsorption of Polystyrene Nanospheres onto the Surface of an Ultrathin Polymer Film prepared by Using an Alternate Adsorption Technique". Langmuir, vol. 14, pp. 4088-4094 (1998). |
Sethu, P; "Microfluidic diffusive filter for apheresis (leukopheresis)"; Lab Chip, vol. 6, No. 1, pp. 83-89 (Jan. 2006); Published electronically Nov. 11, 2005. |
Seul et al., "Domain Shapes and Patterns: The Phenomenology of Modulated Phases", Science, vol. 267:476-483 (1995). |
Seul et al., "Scale transformation of magnetic bubble arrays: coupling of topological disorder and polydispersity". Science, vol. 262: 558-560 (1993). |
Sgaramella, V., et al., "Total Synthesis of the Structural Gene for an Alanine Transfer RNA from Yeast. Enzymic Joining of the Chemically Synthesized Polydeoxynucleotides to form the DNA Duplex Representing Nucleotide Sequence 1 to 20". J. Mol. Biology, vol. 72, pp. 427-444 (1972). |
Sham , P. et al., "Haplotype Association of Discrete and Continuous Traits Using Mixture of Regression Models", Behavior Genetics, Mar. 2004, 34(2), pp. 207-214. |
Shevkoplyas, S., et al., "Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device"; American Chemical Society; vol. 77, No. 3, pp. 933-937 (Feb. 1, 2005). |
Shon. "Application Note—New Best Practices for Biosample Management: Moving Beyond Freezers". American Biotechnology Laboratory, vol. 23, No. 2, pp. 10-13 (2005). |
Shoyer, Terrie W., et al., "A Rapid Flow Cytometry Assay for HLA Antibody Detection Using a Pooled Cell Panel Convering 14 Serological Crossreacting Groups". Transplantation, vol. 59, No. 4, pp. 626-630 (1995). |
Siegel, D., "Phage display-based molecular methods in immunohematology". Transfusion, vol. 47, pp. 89S-94S (Jul. 2007 Supplement). |
Simon, R. "Application of optimization methods to the hematological support of patients with disseminated malignacies", Mathematical Biosciences, vol. 25, 1975, pp. 125-138. |
Skalnik et al., "A Rapid Method for Characterizing transgenic Mice", S. Biotechniques 8:34 (1990). |
Skolnick et al. "Simultaneous analysis of multiple polymorphic loci using amplified sequence polymorphisms (ASPs)". Genomics, vol. 2, pp. 273-279 (1988). |
Smay, J., et al., "Colloidal Inks for Directed Assembly of 3-D Peridoic Structures". Langmuir, vol. 18, pp. 5429-5437 (2002). |
Smith, J. W., et al., "RED: A Red-Cell Antibody Identification Expert Module". Journal of Medical Systems, vol. 9, No. 3, pp. 121-138 (1985). |
Southern E. M., "DNA Fingerprinting by hybridisation to oligonucleotide arrays". Electrophoresis, vol. 16, No. 9, pp. 1539-1542 (1995). |
Southern, E. M., et al., "Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models". vol. 13, No. 4, pp. 1008-1017 (Aug. 1992). |
St. Louis, M, et al., "The Dombrock blood group system: A Review" , Transfusion 43: 1126-1132 (2003). |
Steemers, F.J. (2000) Screening unlabeled DNA targets with randomly ordered fiber-optic gene arrays. Nat. Biotechnol., 18, 91-94. |
Stemmer, C., et al., "Use of Magnetic Beads for Plasma Cell-free DNA Extraction: Toward Automation of Plasma DNA Analysis for Molecular Diagnostics". Clinical Chemistry, vol. 49, No. 11, pp. 1953-1955 (2003). |
Stevens, P. W., et al. "Imaging and Analysis of Immobilized Particle Arrays". Analytical Chemistry. vol. 75, pp. 1147-1154 (2003). |
Storry et al, "Genetic Basis of blood group diversity". British Journal of Haematology, vol. 126, pp. 759-771 (2004). |
Strobel E., et al., "The molecular basis of Rhesus antigen E", Transfusion 44:407-409 (2004). |
Sukhishvilli, S.A. et al. "Adsorption of human serum albumin: Dependence on molecular architecture of the oppositely charged surface" J. Chem. Phys. 110, 10153-10161 (1999). |
Sun et al., "Continuous, Flow-Through Immunomagnetic Cell Sorting in a Quadrupole Field". Cytometry, vol. 33, pp. 469-475 (1998). |
Suzawa et al., "Adsorption of Plasma Proteins onto Polymer Latices". Advances in Colloid and Interface Science, vol. 35, pp. 139-172 (1991). |
Svitel, et al., "Combined Affinity and Rate Constant Distributions of Ligand Populations from Experimental Surface Binding Kinetics and Equilibria". Biophysical Journal, vol. 84, pp. 4062-4077 (Jun. 2003). |
Syvanen, "From Gels to Chips: Minisequencing Primer Extensions for Analysis of Pont Mutations and Single Nucelotide Polymorphisms", Human Mutation 13:1-10 (1999). |
Syvanen, A., et al., "Identification of Individuals by Analysis of Biallelic DNA Markers, Using PCR and Solid-Phase Minisequencing". Am. J. Hum. Genet, vol. 52, pp. 46-59 (1993). |
Syvannen, A. "Toward genone-wide SNP genotyping". Nature Genetics Supplement. vol. 37: s5-s10 (2005). |
Sze. MIS Diode and Charge-Coupled Device. The Physics of Semiconductors, Chapter 7, pp. 362-430 (2nd Edition) (1981). |
Takeda et al. "Conformational Change of Bovine Serum Albumin by Heat Treatment", J. Protein Chemistry 8:653-659, No. 5 (1989). |
Tanaka, T., et al., "Mechanical instability of gels at the phase transition", Nature, vol. 325, pp. 796-798 (1987). |
Taniguchi et al. "Adsorption/desorption behavior and covalent grafting of an antibody onto cationic amino-functionalized poly(styrene-N-isoprapylacrylamide) core-shell latex particles". Colloids and Surfaces B: Biointerfaces. vol. 29: 53-65 (2003). |
Tarnok et al., "Cytometric Bead Array to Measure Six Cytokines in Twenty-Five Microliters of Serum," Clinical Chemistry, (2003), vol. 49, No. 6, pp. 1000-1002. |
Taylor et al., "Linked oligodeoxynucleotides show binding cooperativity and can selectively impair replication of deleted mitochondrial DNA templates", Nucleic Acids Research. vol. 29, No. 16, pp. 3404-3412 (2001). |
Tobitani et al. "Heat-induced gelation of globular proteins 2. Effect of environmental factors on single-component and mixed-protein gels," Macromolecules; vol. 30: 4855-4862 (1997). |
Tobitani et al. "Heat-induced gelation of globular proteins. 1. Model for the effects of time and temperature onthe gelation time of BSA gels." Macromolecules. vol. 30:4845-4854 (1997). |
Tokumasu F. et al., Development and application of quantum dots for immunocytochemistry of human erythrocytes, J. Microscopy, 2003, pp. 256-261, vol. 211, pt. 3. |
Tonisson et al., "Arrayed primer extension on the DNA chip; Method and applications", Microarray Biochip Technology, Biotechniques Books, 247-262 (2000). |
Trang D.T.X. et al. "One step concentration of malarial parasite-infected red blood cells and removal of contaminating white blood cells" , Malaria Journal (2004) pp. 1-7 from http://www.malariajournal.com/content/3/1/7. |
Trau et al., "Field-induced layering of colloidal crystal", Science, vol. 272; pp. 706-709 (1996). |
Trau et al., "Nanoencapsulated microcrystalline particles for superamplified biochemical assays", Anal. Chem, vol. 74, No. 21, pp. 5480-5486. Web Release Date: Sep. 25, 2002. |
Tsuchihashi, Z. et al. "Progress in high throughput SNP genotyping methods", The Pharmacogenomics Journal 2:103-110 (Apr. 2002). |
Turcanu et al, "Cell Identification and isolation on the basis of cytokine secretion: A novel tool for investigating immune responses". Nature Medicine, vol. 7, No. 3, pp. 373-376 (Mar. 2001). |
Tyagi et al., Molecular Beacons: Probes that Flouresce upon Hybridization, Nature Biotechnology vol. 14, pp. 303-308 (1996). |
Vainrub, A., et al., "Sensitive quantitative nucleic acid detection using oligonucleotide microarrays". Journal of the American Chemical Society, vol. 125, No. 26, pp. 7798-7799, (Jun. 2003). |
Van Kempen, et al., "Mean and Variance of Ratio Estimators Used in Fluorescence Ratio Imaging". Cytometry, vol. 39, pp. 300-305 (2000). |
Van Zoelen, "Receptor-ligan interaction: a new method for determing binding parameters without a priori assumptions on non-specific binding". Biochem J., vol. 262, pp. 549-556 (1989). |
Vasiliskov, A. V., et al., "Fabrication of Microarray of Gel-Immobilized Compounds on a Chip by Copolymerization". BioTechniques, vol. 27, pp. 592-606 (Sep. 1999). |
Vaynberg et al. "Structure and extent of absorded gelatin on acrylic latex and polystyrene collodial particles". Journal of Colloid and Interface Science. vol. 205:131-140 (1998). |
Vet, J.A.M. (1999) Multiplex detection of four pathogenic retroviruses using molecular beacon. Proc. Natl. Acad. Sci. USA, 96, 6394-6399. |
Vilain. "CYPs, SNPs, and Molecular Diagnosis in the Postgenomic Era". Clinical Chemistry, vol. 44, pp. 2403-2404 (1998). |
Vorlop, K. D., et al., "Entrapment of Microbial Cells within Polyurethane Hydrogel Beads with the Advantage of Low Toxicity", Biotechnology Techniques, vol. 6, No. 6, pp. 483-488 (1992). |
Wahl et al., "Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate". Proc. Natl. Acad. Sci. USA. vol. 76, No. 8: 3583-3687 (1979). |
Wang, D., et al, "Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome". Science, vol. 280, No. 5366, pp. 1077-1082 (May 15, 1998). |
Warren, J. A., "Selected Spacings During Directional Solidification of a Binary Alloy", Spatio-Temporal Patterns, Ed. P. E., Cladis and P. Palffy-Muhoray, SFI Studies in the Science of Complexity, Addison-Wesley, pp. 91-105 (1995). |
Weinfeld et al., "Selective hydrolysis by exo- and endonucleases of phosphodiester bonds adjacent to an apurinic site". Nucleic Acids Research, vol. 17, No. 10: 3735-3744 (1989). |
Weissenbach et al. "A Second generation linkage map of the human genome". Nature, vol. 359, pp. 794-801 (1992). |
Wen, et al., "Planar Magnetic Colloidal Crystals". Physical Review Letters, vol. 85, No. 25, pp. 5464-5467 (2000). |
Wiedmann, M., et al., Ligase Chain Reaction (LCR)—Overview and Applications, PCR Methods and Applications, Genome Research, vol. 3, pp. s51-s64 (1994). |
Wilson et al., "A generalized method for magnetite nanoparticle steric stabilization utilizing block copolymers containing carboxylic acids". European Cells and Materials, vol. 2, Suppl 2, pp. 202-209 (2002). |
Wilson, M. R., et al., "A New Microsphere-based Immunofluorescence Assay for Antibodies to Membrane-associated Antigens". Journal of Immunological Methods, vol. 107, pp. 231-237 (1988). |
Wittemann et al., "Interaction of Proteins with Spherical Polyelectrolyte Brushes" (Polyer Institute, University of Karisruhe, Karisruhe, Germany) Poster Oct. 2001. |
Yamashita et al., "Thermodynamics for the preparation of micron-sized, monodispersed highly monomer absorbed polymer particles utilizing the dynamic selling method". Colloids and Surfaces, vol. 153, pp. 153-159 (1999). |
Yao et al., "Molecular-beacon-based array for sensitive DNA analysis". Analytical Biochemistry, vol. 331, pp. 216-223 (2004). |
Ye et al., "Fluorescent Microsphere-Based Readout Technology for Multiplexed Human Single Nucleotide Polymorphism Analysis and Bacterial Identification" Human Mutation, Apr. 17, 2001 (4); 305-16). |
Yeang et. al. Molecular classification of multiple tumor types. Bioinformatics vol. 17 Suppl. 1, pp. s316-s322 (2001). |
Yeh, S. R., et al., "Assembly of ordered colloidal aggregares by electric-field-induced fluid flow". Nature, Mar. 6, 1997; vol. 386, No. 6620, pp. 57-59. |
Yellen, B. B., et al., "Programmable Assembly of Colloidal Particles Using Magnetic Microwell Templates". Langmuir, p. est 6.5 (2004). |
Yellen, et al., "Statistical Analysis of Weakest Link in Chains of Magnetic Particle Carriers for Applications in Printing Biochemical Arrays". European Cells and Materials, vol. 3, pp. 88-91 (2002). |
Yershov et al., "DNA analysis and diagnostics on oligonulceotide microchips". Proceedings of the National Academy of Sciences of the United States of America, vol. 93, No. 10, pp. 4913-4918 (May 14, 1996). |
Zaer, Farid, et al., "Antibody Screening by Enzyme-Linked Immunosorbent Assay Using Pooled Soluble HLA in Renal Transplant Candidates". Transplantation, vol. 63, No. 1, pp. 48-51 (Jan. 15, 1997). |
Zborowski, et al., "Continuous cell separation using novel magnetic quadruple flow sorter". Journal of Magnetism and Magnetic Materials, vol. 194, pp. 224-230 (1999). |
Zhang et al., "Nuclear DNA analysis in genetic studies of populations; practice, problems and prospects" Molecular Ecology. vol. 12:563-584 (2003). |
Zhang et al., "Reconstruction of DNA sequencing by hybridization". Bioinformatics, vol. 19, No. 1, pp. 14-21 (2003). |
Zhang, X., et al., "Strand invasion by mixed base PNAs and a PNA-peptide chimera". Nucleic Acids Research, vol. 28, No. 17, pp. 3332-3338 (2000). |
Zhang, Y., et al., "Reproducible and inexpensive probe preparation for oligonucleotide arrays". Nucleic Acids Research, vol. 29, No. 13, pp. E66-6 (Jul. 1, 2001). |
Also Published As
Publication number | Publication date |
---|---|
US7927796B2 (en) | 2011-04-19 |
US20050288870A1 (en) | 2005-12-29 |
US20110184655A1 (en) | 2011-07-28 |
WO2005029705A2 (en) | 2005-03-31 |
WO2005029705A3 (en) | 2005-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6524793B1 (en) | Multiplexed analysis of clinical specimens apparatus and method | |
US5981180A (en) | Multiplexed analysis of clinical specimens apparatus and methods | |
US20230295690A1 (en) | Haplotype resolved genome sequencing | |
EP3234602B1 (en) | Methods for identifying multiple epitopes in selected sub-populations of cells | |
US8309317B2 (en) | Method of screening single cells for the production of biologically active agents | |
US20040059519A1 (en) | Multiplexed analysis of clinical specimens apparatus and methods | |
WO1997014028A9 (en) | Multiplexed analysis of clinical specimens apparatus and method | |
US20040049354A1 (en) | Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants | |
CN106778073B (en) | A kind of method and system of assessment tumor load variation | |
WO1999036564A9 (en) | Multiplexed analysis of clinical specimens apparatus and methods | |
CA2980327A1 (en) | Alignment and variant sequencing analysis pipeline | |
Orzińska et al. | A preliminary evaluation of next-generation sequencing as a screening tool for targeted genotyping of erythrocyte and platelet antigens in blood donors | |
US20140358446A1 (en) | Selection of Genotyped Transfusion Donors by Cross-Matching to Genotyped Recipients | |
Reid | Transfusion in the age of molecular diagnostics | |
Monserrat et al. | Genetics of cardiomyopathies: novel perspectives with next generation sequencing | |
JP2004533830A (en) | Tools for diagnosis, molecular determination, and therapeutic development for chronic inflammatory joint disease | |
US8615367B2 (en) | Number coding for identification of subtypes of coded types of solid phase carriers | |
US8148171B2 (en) | Multiplexed analysis of clinical specimens apparatus and methods | |
Eshaque et al. | Technology platforms for molecular diagnosis of cystic fibrosis | |
CN114171116A (en) | Method for evaluating fetal DNA concentration by free and self DNA of pregnant woman and application | |
Cortini et al. | Clinical application of NGS tools in the diagnosis of collagenopathies | |
KR100450816B1 (en) | Selection method of probe set for genotyping | |
Soucy et al. | Molecular Genetic Testing Approaches for Retinitis Pigmentosa | |
White | Looking for epilepsy genes | |
Strauss et al. | Value of DNA-based assays for donor screening and regulatory issues |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: CITIBANK, N.A., AS ADMINISTRATIVE AGENT, DELAWARE Free format text: PATENT SECURITY AGREEMENT;ASSIGNORS:IMMUCOR, INC.;BIOARRAY SOLUTIONS LTD.;REEL/FRAME:026778/0640 Effective date: 20110819 |
|
REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees |
Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.) |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20171224 |
|
AS | Assignment |
Owner name: IMMUCOR, INC., GEORGIA Free format text: RELEASE OF PATENT SECURITY INTERESTS;ASSIGNOR:CITIBANK, N.A.;REEL/FRAME:053121/0935 Effective date: 20200702 Owner name: SIRONA GENONICS, INC., MASSACHUSETTS Free format text: RELEASE OF PATENT SECURITY INTERESTS;ASSIGNOR:CITIBANK, N.A.;REEL/FRAME:053121/0935 Effective date: 20200702 Owner name: IMMUCOR GTI DIAGNOSTICS, INC., GEORGIA Free format text: RELEASE OF PATENT SECURITY INTERESTS;ASSIGNOR:CITIBANK, N.A.;REEL/FRAME:053121/0935 Effective date: 20200702 Owner name: BIOARRAY SOLUTIONS LTD., NEW JERSEY Free format text: RELEASE OF PATENT SECURITY INTERESTS;ASSIGNOR:CITIBANK, N.A.;REEL/FRAME:053121/0935 Effective date: 20200702 |