US7632262B2 - Systems and methods for atraumatic implantation of bio-active agents - Google Patents
Systems and methods for atraumatic implantation of bio-active agents Download PDFInfo
- Publication number
- US7632262B2 US7632262B2 US10/894,810 US89481004A US7632262B2 US 7632262 B2 US7632262 B2 US 7632262B2 US 89481004 A US89481004 A US 89481004A US 7632262 B2 US7632262 B2 US 7632262B2
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- United States
- Prior art keywords
- tissue
- catheter
- distal end
- needle
- elongated member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
- A61B2017/00398—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like using powered actuators, e.g. stepper motors, solenoids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
- A61B2017/00871—Material properties shape memory effect polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
- A61B2017/3405—Needle locating or guiding means using mechanical guide means
- A61B2017/3411—Needle locating or guiding means using mechanical guide means with a plurality of holes, e.g. holes in matrix arrangement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B2017/348—Means for supporting the trocar against the body or retaining the trocar inside the body
- A61B2017/3482—Means for supporting the trocar against the body or retaining the trocar inside the body inside
- A61B2017/3484—Anchoring means, e.g. spreading-out umbrella-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00392—Transmyocardial revascularisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
Definitions
- the needle further comprises means for creating a tissue space surrounding a distal or lateral surface of the needle, thereby permitting bioactive agent to be infused into the space without retracting the needle.
- the means for creating the tissue space may take the form of one or more expandable struts that are deployed to create a space surrounding the needle, and permit the bioactive agent to be infused into apertures that rest in a lateral surface of the needle.
- the needle may be fluted or grooved, so that the outer edges of the flutes support the tissue and form a space into which the bioactive agent may be infused via apertures at the base of the flutes.
- FIGS. 1A-1C are views depicting previously known methods of injecting drugs and other bioactive agents into a tissue mass
- valve 39 closes to decouple vial 40 from the lumen of needle 34 . This prevents the bioactive agent from being deposited at the needle track entrance, and reduces the risk that the bioactive agent will be ejected from the needle track entrance and embolize. Catheter 31 may then be repositioned, and the above process repeated. Depending upon the selection of valve 39 , operation of valve 39 may be controlled by the physician or may be arranged to operate automatically.
- Needle 154 then is retracted, and catheter 151 may be advanced further along guide wire 157 to deposit the bioactive agent along additional sites in the myocardium accessible via the coronary veins. While use of the coronary veins in this manner simplifies the delivery system by obviating the guide systems of FIGS. 6-9 , epicardial access via the coronary veins will be limited to the sites accessible from those veins.
Abstract
Description
Claims (31)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/894,810 US7632262B2 (en) | 2004-07-19 | 2004-07-19 | Systems and methods for atraumatic implantation of bio-active agents |
US10/977,594 US7338471B2 (en) | 2004-07-19 | 2004-10-29 | Apparatus and methods for treating tissue using passive injection systems |
EP05772267A EP1773440B1 (en) | 2004-07-19 | 2005-07-18 | Apparatus for treating tissue using passive injection systems |
JP2007522630A JP4934029B2 (en) | 2004-07-19 | 2005-07-18 | Apparatus and method for treating tissue using a passive injection system |
PCT/US2005/025470 WO2006020256A2 (en) | 2004-07-19 | 2005-07-18 | Systems and methods for atraumatic implantation of bio-active agents |
EP11150671.3A EP2340868B1 (en) | 2004-07-19 | 2005-07-18 | Apparatus for atraumatic implantation of bio-active agents |
JP2007522631A JP4774403B2 (en) | 2004-07-19 | 2005-07-18 | System and method for non-invasive implantation of bioactive substances |
AT05772267T ATE526054T1 (en) | 2004-07-19 | 2005-07-18 | DEVICE FOR TREATING TISSUE USING PASSIVE INJECTION SYSTEMS |
CA2573844A CA2573844C (en) | 2004-07-19 | 2005-07-18 | Systems and methods for atraumatic implantation of bio-active agents |
PCT/US2005/025469 WO2006020255A2 (en) | 2004-07-19 | 2005-07-18 | Apparatus and methods for treating tissue using passive injection systems |
AU2005274774A AU2005274774B2 (en) | 2004-07-19 | 2005-07-18 | Apparatus for treating tissue using passive injection systems |
CA2574089A CA2574089C (en) | 2004-07-19 | 2005-07-18 | Apparatus and methods for treating tissue using passive injection systems |
EP11150581A EP2343099A1 (en) | 2004-07-19 | 2005-07-18 | Apparatus for treating tissue using passive injection systems |
AU2005274775A AU2005274775B2 (en) | 2004-07-19 | 2005-07-18 | Systems and methods for atraumatic implantation of bio-active agents |
EP20050773060 EP1773441B1 (en) | 2004-07-19 | 2005-07-18 | Systems and methods for atraumatic implantation of bio-active agents |
US12/041,561 US7862551B2 (en) | 2004-07-19 | 2008-03-03 | Apparatus and methods for treating tissue using passive injection systems |
US12/637,701 US8377032B2 (en) | 2004-07-19 | 2009-12-14 | Systems and methods for atraumatic implantation of bio-active agents |
US12/978,293 US20110152833A1 (en) | 2004-07-19 | 2010-12-23 | Apparatus and methods for treating tissue using passive injection systems |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/894,810 US7632262B2 (en) | 2004-07-19 | 2004-07-19 | Systems and methods for atraumatic implantation of bio-active agents |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/977,594 Continuation-In-Part US7338471B2 (en) | 2004-07-19 | 2004-10-29 | Apparatus and methods for treating tissue using passive injection systems |
US12/637,701 Division US8377032B2 (en) | 2004-07-19 | 2009-12-14 | Systems and methods for atraumatic implantation of bio-active agents |
Publications (2)
Publication Number | Publication Date |
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US20060015085A1 US20060015085A1 (en) | 2006-01-19 |
US7632262B2 true US7632262B2 (en) | 2009-12-15 |
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Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
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US10/894,810 Active 2025-03-05 US7632262B2 (en) | 2004-07-19 | 2004-07-19 | Systems and methods for atraumatic implantation of bio-active agents |
US10/977,594 Active 2025-03-15 US7338471B2 (en) | 2004-07-19 | 2004-10-29 | Apparatus and methods for treating tissue using passive injection systems |
US12/041,561 Active 2024-08-17 US7862551B2 (en) | 2004-07-19 | 2008-03-03 | Apparatus and methods for treating tissue using passive injection systems |
US12/637,701 Active US8377032B2 (en) | 2004-07-19 | 2009-12-14 | Systems and methods for atraumatic implantation of bio-active agents |
US12/978,293 Abandoned US20110152833A1 (en) | 2004-07-19 | 2010-12-23 | Apparatus and methods for treating tissue using passive injection systems |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/977,594 Active 2025-03-15 US7338471B2 (en) | 2004-07-19 | 2004-10-29 | Apparatus and methods for treating tissue using passive injection systems |
US12/041,561 Active 2024-08-17 US7862551B2 (en) | 2004-07-19 | 2008-03-03 | Apparatus and methods for treating tissue using passive injection systems |
US12/637,701 Active US8377032B2 (en) | 2004-07-19 | 2009-12-14 | Systems and methods for atraumatic implantation of bio-active agents |
US12/978,293 Abandoned US20110152833A1 (en) | 2004-07-19 | 2010-12-23 | Apparatus and methods for treating tissue using passive injection systems |
Country Status (7)
Country | Link |
---|---|
US (5) | US7632262B2 (en) |
EP (4) | EP1773440B1 (en) |
JP (2) | JP4934029B2 (en) |
AT (1) | ATE526054T1 (en) |
AU (2) | AU2005274775B2 (en) |
CA (2) | CA2573844C (en) |
WO (2) | WO2006020255A2 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US20100331814A1 (en) * | 2004-07-19 | 2010-12-30 | Bates Mark C | Systems And Methods For Atraumatic Implantation Of Bio-Active Agents |
US20110270191A1 (en) * | 2008-12-31 | 2011-11-03 | Saurav Paul | Fast-acting or rotating transseptal needle |
US20170266414A1 (en) * | 2016-03-16 | 2017-09-21 | Krishna Rocha-Singh, M.D. | Apparatus and method for promoting angiogenesis in ischemic tissue |
US9956384B2 (en) | 2014-01-24 | 2018-05-01 | Cook Medical Technologies Llc | Articulating balloon catheter and method for using the same |
US10398844B2 (en) | 2012-11-02 | 2019-09-03 | Cook Medical Technologies Llc | Controlled injection devices, systems, and methods |
US10835215B2 (en) | 2012-09-12 | 2020-11-17 | Convergent Life Sciences, Inc. | Method and apparatus for laser ablation under ultrasound guidance |
US11071849B2 (en) | 2015-08-18 | 2021-07-27 | B. Braun Melsungen Ag | Catheter devices with valves and related methods |
US11850377B2 (en) | 2018-12-17 | 2023-12-26 | B. Braun Melsungen Ag | Catheter assemblies and related methods |
US11957850B2 (en) | 2021-01-28 | 2024-04-16 | B. Braun Melsungen Ag | Catheter devices with valves and related methods |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090118673A1 (en) * | 2007-11-07 | 2009-05-07 | Jerett Creed | Needle injection catheter |
US8043257B2 (en) * | 2007-12-06 | 2011-10-25 | Abbott Cardiovascular Systems Inc. | Agent delivery catheter having an inflation bridge between two axially spaced balloons |
US8133208B2 (en) * | 2008-04-02 | 2012-03-13 | Bsecs Holdings, Llc | Injection control method and device |
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US7824359B2 (en) | 2008-07-24 | 2010-11-02 | Solomon Clifford T | Bioinjection device |
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US9931046B2 (en) | 2013-10-25 | 2018-04-03 | Ablative Solutions, Inc. | Intravascular catheter with peri-vascular nerve activity sensors |
US10517666B2 (en) | 2013-10-25 | 2019-12-31 | Ablative Solutions, Inc. | Apparatus for effective ablation and nerve sensing associated with denervation |
US9949652B2 (en) | 2013-10-25 | 2018-04-24 | Ablative Solutions, Inc. | Apparatus for effective ablation and nerve sensing associated with denervation |
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US10631532B1 (en) * | 2016-11-04 | 2020-04-28 | Charles Joseph Kowalski | Invasive plant species infusion applicator |
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US10849685B2 (en) | 2018-07-18 | 2020-12-01 | Ablative Solutions, Inc. | Peri-vascular tissue access catheter with locking handle |
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US20230309910A1 (en) | 2022-04-01 | 2023-10-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Tumescense monitoring system for diagnosing erectile dysfunction and methods of use |
Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880163A (en) | 1973-10-26 | 1975-04-29 | Jack H Ritterskamp | Medicinal syringe actuating device |
US4067334A (en) | 1976-10-29 | 1978-01-10 | Haller J Gilbert | Self-injecting hypodermic syringe device |
US5244460A (en) | 1991-11-27 | 1993-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method to foster myocardial blood vessel growth and improve blood flow to the heart |
US5419777A (en) | 1994-03-10 | 1995-05-30 | Bavaria Medizin Technologie Gmbh | Catheter for injecting a fluid or medicine |
US5531780A (en) | 1992-09-03 | 1996-07-02 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
US5655548A (en) | 1996-09-16 | 1997-08-12 | Circulation, Inc. | Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion |
US5730741A (en) | 1997-02-07 | 1998-03-24 | Eclipse Surgical Technologies, Inc. | Guided spiral catheter |
US5910150A (en) | 1996-12-02 | 1999-06-08 | Angiotrax, Inc. | Apparatus for performing surgery |
US6024120A (en) * | 1998-09-25 | 2000-02-15 | Sherwood Services Ag | Pressure relief valve with moving diaphragm |
US6051008A (en) | 1996-12-02 | 2000-04-18 | Angiotrax, Inc. | Apparatus having stabilization members for percutaneously performing surgery and methods of use |
US6102887A (en) | 1998-08-11 | 2000-08-15 | Biocardia, Inc. | Catheter drug delivery system and method for use |
US6120520A (en) * | 1997-05-27 | 2000-09-19 | Angiotrax, Inc. | Apparatus and methods for stimulating revascularization and/or tissue growth |
US6159196A (en) | 1998-03-09 | 2000-12-12 | Ruiz; Carlos | Methods and apparatus for transvascular muscular revascularization and drug delivery |
US6264637B1 (en) | 1997-06-26 | 2001-07-24 | Thomas Hogan | Marking syringe |
US6302870B1 (en) | 1999-04-29 | 2001-10-16 | Precision Vascular Systems, Inc. | Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like |
US20020049414A1 (en) | 2000-10-03 | 2002-04-25 | Nobles Anthony A. | Fluid delivery and extraction device and method |
US6432119B1 (en) * | 1999-03-17 | 2002-08-13 | Angiotrax, Inc. | Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials |
US20030191449A1 (en) | 1999-08-05 | 2003-10-09 | Kensey Nash Corporation | Systems for delivering agents into targeted tissue of a living being |
US20050261633A1 (en) | 2004-05-19 | 2005-11-24 | Khalaj Ben M | Rechargeable handheld injection device with reversible drive having adjustable syringe cradle |
US7316692B2 (en) * | 2003-08-12 | 2008-01-08 | Boston Scientific Scimed, Inc. | Laser-cut clot puller |
US7338471B2 (en) | 2004-07-19 | 2008-03-04 | Paragon Intellectual Properties, Llc | Apparatus and methods for treating tissue using passive injection systems |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3081770A (en) * | 1960-09-21 | 1963-03-19 | John M Hunter | Surgical instrument |
US3467096A (en) * | 1966-04-12 | 1969-09-16 | Ferrell S Horn | Multiple hypodermic syringe arrangement |
US3941127A (en) * | 1974-10-03 | 1976-03-02 | Froning Edward C | Apparatus and method for stereotaxic lateral extradural disc puncture |
CA1051330A (en) * | 1974-10-09 | 1979-03-27 | John T. Alden | Pneumatic tire |
FR2348709A1 (en) * | 1976-04-23 | 1977-11-18 | Pistor Michel | MESOTHERAPIC TREATMENT PROCESS AND INJECTION DEVICE, FORMING AUTOMATIC MICRO-INJECTOR, INCLUDING APPLICATION |
NZ206650A (en) * | 1982-12-31 | 1987-05-29 | Phillips Pty Ltd N J | Injector, retractable needle shroud activates piston |
GB8522037D0 (en) * | 1985-09-05 | 1985-10-09 | Trimark R & D Ltd | Closure device |
US4687473A (en) * | 1986-02-06 | 1987-08-18 | Burron Medical Inc. | Self-contained secondary solution set |
US4710162A (en) * | 1986-10-31 | 1987-12-01 | Johnson Gerald W | Fat collection and injection process into same body |
US4950233A (en) * | 1988-10-05 | 1990-08-21 | Abramowitz Joseph M | Nerve block needle and safety method of use |
US5284479A (en) * | 1989-08-30 | 1994-02-08 | N.V. Nederlandsche Apparatenfabriek Nedap | Implanter |
US5562613A (en) * | 1991-07-02 | 1996-10-08 | Intermed, Inc. | Subcutaneous drug delivery device |
NL9101489A (en) * | 1991-09-03 | 1993-04-01 | Texas Instruments Holland | INJECTOR FOR IMMEDIATELY IMPLANTING AN OBJECT IN A LIVING BEING. |
US5738650A (en) * | 1993-01-29 | 1998-04-14 | Becton, Dickinson And Company | Subarachnoid needle and method for administering therapeutic agents to the subarachnoid space |
US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
US5464395A (en) * | 1994-04-05 | 1995-11-07 | Faxon; David P. | Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway |
US5540658A (en) * | 1994-06-27 | 1996-07-30 | Innerdyne, Inc. | Transcervical uterine access and sealing device |
DK0783342T3 (en) * | 1994-09-27 | 1999-07-19 | Delab | Security injector |
US5860741A (en) * | 1996-03-25 | 1999-01-19 | Oriental System Technology, Inc. | Absolute radiation thermometer |
US5830210A (en) | 1996-10-21 | 1998-11-03 | Plc Medical Systems, Inc. | Catheter navigation apparatus |
US6102926A (en) * | 1996-12-02 | 2000-08-15 | Angiotrax, Inc. | Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use |
US5830188A (en) * | 1996-12-11 | 1998-11-03 | Board Of Regents, The University Of Texas System | Curved cannula for continuous spinal anesthesia |
US5860739A (en) * | 1997-03-05 | 1999-01-19 | Cannon; Mark L. | Automatic mixing syringe for dental materials |
US5941983A (en) * | 1997-06-24 | 1999-08-24 | Hewlett-Packard Company | Out-of-order execution using encoded dependencies between instructions in queues to determine stall values that control issurance of instructions from the queues |
JPH1142284A (en) * | 1997-07-25 | 1999-02-16 | Ube Ind Ltd | Artificial blood vessel with stent |
US6682500B2 (en) * | 1998-01-29 | 2004-01-27 | David Soltanpour | Synthetic muscle based diaphragm pump apparatuses |
TW356720U (en) * | 1998-03-03 | 1999-04-21 | Chen Jing-Sing | Safety type syringe |
EP1156741B1 (en) * | 1999-02-10 | 2010-12-22 | Sub-Q, Inc. | Device for facilitating hemostasis of a biopsy tract |
US6450937B1 (en) * | 1999-12-17 | 2002-09-17 | C. R. Bard, Inc. | Needle for implanting brachytherapy seeds |
US6599274B1 (en) * | 2000-01-20 | 2003-07-29 | John Kucharczyk | Cell delivery catheter and method |
AU2001273421A1 (en) * | 2000-07-13 | 2002-01-30 | Bioheart, Inc. | Deployment system for myocardial cellular material |
JP2004515118A (en) * | 2000-11-21 | 2004-05-20 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Communication system having bad frame indicator means for resynchronization |
WO2003038075A1 (en) * | 2001-10-30 | 2003-05-08 | Renomedix Institute Inc. | Method of inducing differentiation of mesodermal stem cells, es cells or immortalized cells into nervous system cells |
US20030229321A1 (en) * | 2002-06-05 | 2003-12-11 | Timothy Simon | Needle with slotted tip |
JP2004026761A (en) * | 2002-06-27 | 2004-01-29 | Olympus Corp | Capsule for injecting into affected part and liquid for injecting into affected part |
US20050256361A1 (en) * | 2002-07-03 | 2005-11-17 | Christian Mathieu | Implant inserting device |
US9060844B2 (en) * | 2002-11-01 | 2015-06-23 | Valentx, Inc. | Apparatus and methods for treatment of morbid obesity |
US20050124999A1 (en) * | 2003-10-31 | 2005-06-09 | Teitelbaum George P. | Device and method for radial delivery of a structural element |
-
2004
- 2004-07-19 US US10/894,810 patent/US7632262B2/en active Active
- 2004-10-29 US US10/977,594 patent/US7338471B2/en active Active
-
2005
- 2005-07-18 EP EP05772267A patent/EP1773440B1/en active Active
- 2005-07-18 CA CA2573844A patent/CA2573844C/en active Active
- 2005-07-18 JP JP2007522630A patent/JP4934029B2/en active Active
- 2005-07-18 EP EP11150581A patent/EP2343099A1/en not_active Withdrawn
- 2005-07-18 AT AT05772267T patent/ATE526054T1/en not_active IP Right Cessation
- 2005-07-18 JP JP2007522631A patent/JP4774403B2/en active Active
- 2005-07-18 WO PCT/US2005/025469 patent/WO2006020255A2/en active Application Filing
- 2005-07-18 AU AU2005274775A patent/AU2005274775B2/en active Active
- 2005-07-18 CA CA2574089A patent/CA2574089C/en active Active
- 2005-07-18 EP EP11150671.3A patent/EP2340868B1/en active Active
- 2005-07-18 WO PCT/US2005/025470 patent/WO2006020256A2/en active Application Filing
- 2005-07-18 AU AU2005274774A patent/AU2005274774B2/en active Active
- 2005-07-18 EP EP20050773060 patent/EP1773441B1/en active Active
-
2008
- 2008-03-03 US US12/041,561 patent/US7862551B2/en active Active
-
2009
- 2009-12-14 US US12/637,701 patent/US8377032B2/en active Active
-
2010
- 2010-12-23 US US12/978,293 patent/US20110152833A1/en not_active Abandoned
Patent Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880163A (en) | 1973-10-26 | 1975-04-29 | Jack H Ritterskamp | Medicinal syringe actuating device |
US4067334A (en) | 1976-10-29 | 1978-01-10 | Haller J Gilbert | Self-injecting hypodermic syringe device |
US5244460A (en) | 1991-11-27 | 1993-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method to foster myocardial blood vessel growth and improve blood flow to the heart |
US5531780A (en) | 1992-09-03 | 1996-07-02 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
US5419777A (en) | 1994-03-10 | 1995-05-30 | Bavaria Medizin Technologie Gmbh | Catheter for injecting a fluid or medicine |
US5655548A (en) | 1996-09-16 | 1997-08-12 | Circulation, Inc. | Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion |
US6051008A (en) | 1996-12-02 | 2000-04-18 | Angiotrax, Inc. | Apparatus having stabilization members for percutaneously performing surgery and methods of use |
US5910150A (en) | 1996-12-02 | 1999-06-08 | Angiotrax, Inc. | Apparatus for performing surgery |
US5941893A (en) | 1996-12-02 | 1999-08-24 | Angiotrax, Inc. | Apparatus for transluminally performing surgery |
US5730741A (en) | 1997-02-07 | 1998-03-24 | Eclipse Surgical Technologies, Inc. | Guided spiral catheter |
US6120520A (en) * | 1997-05-27 | 2000-09-19 | Angiotrax, Inc. | Apparatus and methods for stimulating revascularization and/or tissue growth |
US6264637B1 (en) | 1997-06-26 | 2001-07-24 | Thomas Hogan | Marking syringe |
US6159196A (en) | 1998-03-09 | 2000-12-12 | Ruiz; Carlos | Methods and apparatus for transvascular muscular revascularization and drug delivery |
US6346099B1 (en) * | 1998-08-11 | 2002-02-12 | Biocardia, Inc. | Catheter drug delivery system and method for use |
US6102887A (en) | 1998-08-11 | 2000-08-15 | Biocardia, Inc. | Catheter drug delivery system and method for use |
US6024120A (en) * | 1998-09-25 | 2000-02-15 | Sherwood Services Ag | Pressure relief valve with moving diaphragm |
US6432119B1 (en) * | 1999-03-17 | 2002-08-13 | Angiotrax, Inc. | Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials |
US6302870B1 (en) | 1999-04-29 | 2001-10-16 | Precision Vascular Systems, Inc. | Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like |
US20030191449A1 (en) | 1999-08-05 | 2003-10-09 | Kensey Nash Corporation | Systems for delivering agents into targeted tissue of a living being |
US20020049414A1 (en) | 2000-10-03 | 2002-04-25 | Nobles Anthony A. | Fluid delivery and extraction device and method |
US7316692B2 (en) * | 2003-08-12 | 2008-01-08 | Boston Scientific Scimed, Inc. | Laser-cut clot puller |
US20050261633A1 (en) | 2004-05-19 | 2005-11-24 | Khalaj Ben M | Rechargeable handheld injection device with reversible drive having adjustable syringe cradle |
US7338471B2 (en) | 2004-07-19 | 2008-03-04 | Paragon Intellectual Properties, Llc | Apparatus and methods for treating tissue using passive injection systems |
US20080154201A1 (en) | 2004-07-19 | 2008-06-26 | Bates Mark C | Apparatus and Methods for Treating Tissue Using Passive Injection Systems |
Non-Patent Citations (10)
Title |
---|
Bonan, Raoul, "Local Drug Delivery for the Treatment of Thrombus and Restenosis,", J. Invasive Cardiol., 8 (8): 399-402 (Oct. 1996). |
Mack, Charles A., et al., Biologic Bypass with the Use of Adenovirus-Medicated Gene Transfer of the Complementary Deoxyribonucleic Acid for Vascular Endothelial Growth Factor. |
PCT International Search Report for PCT/US05/25469, 3 pages (mailed Oct. 3, 2006). |
PCT International Search Report for PCT/US05/25470, 2 pages (mailed Sep. 21, 2006). |
Sanborn, Timothy A., et al., "Percutaneous Endocardial Gene Therapy: In Vivo Gene Transfer and Expression," J. Am. Coll. Card., 33 (2 Suppl.): 262A ( Feb. 1999). |
Thompson, Craig A., et al., "Percutaneous Transvenous Cellular Cardiomyoplasty", J. Am. Coll. Card., 41 (11): 1964-1971 (Jun. 2003). |
Uchida, Yangisawa-Miwa A.,et al., Angiogenic Therapy of Acute Myocardial Infarction by Intrapericardial Injection of Basic Fibroblast Growth Factor and Heparin Sulfate: An Ex. |
USPTO Notice of Allowance and Notice of Allowability for U.S. Appl. No. 10/977,594, 7 pages (mailed Oct. 9, 2007). |
USPTO Office Action (final) for U.S. Appl. No. 10/977,594, 6 pages (mailed Jun. 1, 2007). |
USPTO Office Action (non-final) for U.S. Appl. No. 10/977,594, 6 pages (mailed Dec. 15. 2006). |
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