US6051719A - Dibenzorhodamine dyes - Google Patents
Dibenzorhodamine dyes Download PDFInfo
- Publication number
- US6051719A US6051719A US09/193,374 US19337498A US6051719A US 6051719 A US6051719 A US 6051719A US 19337498 A US19337498 A US 19337498A US 6051719 A US6051719 A US 6051719A
- Authority
- US
- United States
- Prior art keywords
- compound
- group
- carbons
- dye
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/02—Diaryl- or thriarylmethane dyes derived from diarylmethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Abstract
Description
NUC--D
NUC--D FORMULA III
NUC--C.tbd.C--CH.sub.2 OCH.sub.2 CH.sub.2 NR.sub.3 X--D
______________________________________ Absorption Emission Full Width at Dye Maximum (nm) Maximum (nm) Half Max (nm) ______________________________________ 41 585 614 59 42 609 634 42 43 597 637 47 44 598 640 50 45 639 650 31 46 639 652 33 47 632 676 66 ______________________________________
Claims (51)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/193,374 US6051719A (en) | 1997-11-25 | 1998-11-17 | Dibenzorhodamine dyes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/978,775 US5936087A (en) | 1997-11-25 | 1997-11-25 | Dibenzorhodamine dyes |
US09/193,374 US6051719A (en) | 1997-11-25 | 1998-11-17 | Dibenzorhodamine dyes |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/978,775 Continuation-In-Part US5936087A (en) | 1997-11-25 | 1997-11-25 | Dibenzorhodamine dyes |
Publications (1)
Publication Number | Publication Date |
---|---|
US6051719A true US6051719A (en) | 2000-04-18 |
Family
ID=25526378
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/978,775 Expired - Lifetime US5936087A (en) | 1997-11-25 | 1997-11-25 | Dibenzorhodamine dyes |
US09/193,374 Expired - Lifetime US6051719A (en) | 1997-11-25 | 1998-11-17 | Dibenzorhodamine dyes |
US09/199,402 Expired - Lifetime US6111116A (en) | 1997-11-25 | 1998-11-24 | Dibenzorhodamine dyes |
US09/556,040 Expired - Lifetime US6221606B1 (en) | 1997-11-25 | 2000-04-20 | Dibenzorhodamine dyes |
US09/784,943 Expired - Lifetime US6326153B2 (en) | 1997-11-25 | 2001-02-14 | Polynucleotides labeled with dibenzorhodamine dyes |
US09/969,430 Expired - Lifetime US6566071B2 (en) | 1997-11-25 | 2001-10-02 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US10/441,950 Expired - Fee Related US6919445B2 (en) | 1997-11-25 | 2003-05-20 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US11/177,233 Abandoned US20060051791A1 (en) | 1997-11-25 | 2005-07-07 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US11/466,085 Abandoned US20070099210A1 (en) | 1997-11-25 | 2006-08-21 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes |
US12/169,624 Expired - Fee Related US7833756B2 (en) | 1997-11-25 | 2008-07-08 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US12/899,508 Abandoned US20110124510A1 (en) | 1997-11-25 | 2010-10-06 | Methods of labeling polynucleotide with dibenzorhodamine dyes |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/978,775 Expired - Lifetime US5936087A (en) | 1997-11-25 | 1997-11-25 | Dibenzorhodamine dyes |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/199,402 Expired - Lifetime US6111116A (en) | 1997-11-25 | 1998-11-24 | Dibenzorhodamine dyes |
US09/556,040 Expired - Lifetime US6221606B1 (en) | 1997-11-25 | 2000-04-20 | Dibenzorhodamine dyes |
US09/784,943 Expired - Lifetime US6326153B2 (en) | 1997-11-25 | 2001-02-14 | Polynucleotides labeled with dibenzorhodamine dyes |
US09/969,430 Expired - Lifetime US6566071B2 (en) | 1997-11-25 | 2001-10-02 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US10/441,950 Expired - Fee Related US6919445B2 (en) | 1997-11-25 | 2003-05-20 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US11/177,233 Abandoned US20060051791A1 (en) | 1997-11-25 | 2005-07-07 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US11/466,085 Abandoned US20070099210A1 (en) | 1997-11-25 | 2006-08-21 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes |
US12/169,624 Expired - Fee Related US7833756B2 (en) | 1997-11-25 | 2008-07-08 | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US12/899,508 Abandoned US20110124510A1 (en) | 1997-11-25 | 2010-10-06 | Methods of labeling polynucleotide with dibenzorhodamine dyes |
Country Status (6)
Country | Link |
---|---|
US (11) | US5936087A (en) |
EP (4) | EP1408090A1 (en) |
JP (3) | JP4038017B2 (en) |
AU (1) | AU742571B2 (en) |
CA (1) | CA2311476C (en) |
WO (1) | WO1999027020A1 (en) |
Cited By (77)
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US20010055763A1 (en) * | 1998-12-24 | 2001-12-27 | Sharat Singh | Individually addressable solid surfaces for multiplexed operations |
US6403311B1 (en) * | 1997-02-12 | 2002-06-11 | Us Genomics | Methods of analyzing polymers using ordered label strategies |
US20020119455A1 (en) * | 1997-02-12 | 2002-08-29 | Chan Eugene Y. | Methods and products for analyzing polymers |
WO2003010524A1 (en) | 2001-07-25 | 2003-02-06 | Applera Corporation | Time-delay integration in electrophoretic detection systems |
US6566071B2 (en) | 1997-11-25 | 2003-05-20 | Applera Corporation | Methods of labelling polynucleotides with dibenzorhodamine dyes |
US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
US20030215864A1 (en) * | 2002-04-23 | 2003-11-20 | U.S. Genomics, Inc. | Compositions and methods related to two-arm nucleic acid probes |
US6686065B2 (en) | 2001-12-12 | 2004-02-03 | Canon Kabushiki Kaisha | [5]-helicene and dibenzofluorene materials for use in organic light emitting devices |
US20040053399A1 (en) * | 2002-07-17 | 2004-03-18 | Rudolf Gilmanshin | Methods and compositions for analyzing polymers using chimeric tags |
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AU1418299A (en) | 1999-06-15 |
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WO1999027020A1 (en) | 1999-06-03 |
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US6919445B2 (en) | 2005-07-19 |
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US20040072209A1 (en) | 2004-04-15 |
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US5936087A (en) | 1999-08-10 |
US20090068751A1 (en) | 2009-03-12 |
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