US5880327A - Transgenic mammals expressing human coagulation factor VIII - Google Patents
Transgenic mammals expressing human coagulation factor VIII Download PDFInfo
- Publication number
- US5880327A US5880327A US08/308,518 US30851894A US5880327A US 5880327 A US5880327 A US 5880327A US 30851894 A US30851894 A US 30851894A US 5880327 A US5880327 A US 5880327A
- Authority
- US
- United States
- Prior art keywords
- factor viii
- protein
- human
- milk
- transgenic mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Abstract
Description
______________________________________ Factor VIII PDL Designation Sample vol.* antigen Mouse ID no. μl units/ml ng/ml ______________________________________ Control D15 100 0.041 8.2 F2.1.13.9 100 0.045 9.0 F2.1.9.10 50 0.100 20.0 F2.1.22.8 40 0.144 28.8 F2.1.13.13 50 0.093 18.6 ______________________________________ *Samples stored at -20° C. In 2 animals, storage of the milk at 4° C. led to reduced values a recombinant human FV III.
__________________________________________________________________________ SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 2 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: CCCCAGCTGCAGCCATGAAG20 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: CCCCAGGGATATCCCTGCAGCCATGAAG28 __________________________________________________________________________
Claims (42)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/308,518 US5880327A (en) | 1994-09-21 | 1994-09-21 | Transgenic mammals expressing human coagulation factor VIII |
DE69534907T DE69534907T2 (en) | 1994-09-21 | 1995-09-21 | TRANSGENIC PIGS EXPRESSING HUMAN CONCENTRATION FACTORY VIII |
JP8510993A JPH10506013A (en) | 1994-09-21 | 1995-09-21 | Transgenic animals expressing human coagulation factor VIII and von Willebrand factor |
PCT/US1995/011781 WO1996009377A1 (en) | 1994-09-21 | 1995-09-21 | Transgenic animals expressing human coagulation factor viii and von willebrand factor |
EP95933128A EP0807170B1 (en) | 1994-09-21 | 1995-09-21 | Transgenic pigs expressing human coagulation factor viii |
AT95933128T ATE321785T1 (en) | 1994-09-21 | 1995-09-21 | TRANSGENIC PIGS EXPRESSING HUMAN BLOOD CLOTTING FACTOR VIII |
EP06006431A EP1739170A3 (en) | 1994-09-21 | 1995-09-21 | Transgenic animal expressing human coagulation factor VII and von Willebrand factor |
CA2200610A CA2200610C (en) | 1994-09-21 | 1995-09-21 | Transgenic animals expressing human coagulation factor viii and von willebrand factor |
ES95933128T ES2262143T3 (en) | 1994-09-21 | 1995-09-21 | TRANSGENICAL PIGS THAT EXPRESS FACTOR VIII OF HUMAN COAGULATION. |
US09/262,017 US6255554B1 (en) | 1994-09-21 | 1999-03-04 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
JP2009188810A JP2010017184A (en) | 1994-09-21 | 2009-08-18 | Transgenic animal expressing human coagulation factor viii and von willebrand factor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/308,518 US5880327A (en) | 1994-09-21 | 1994-09-21 | Transgenic mammals expressing human coagulation factor VIII |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/262,017 Division US6255554B1 (en) | 1994-09-13 | 1999-03-04 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
Publications (1)
Publication Number | Publication Date |
---|---|
US5880327A true US5880327A (en) | 1999-03-09 |
Family
ID=23194291
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/308,518 Expired - Lifetime US5880327A (en) | 1994-09-21 | 1994-09-21 | Transgenic mammals expressing human coagulation factor VIII |
US09/262,017 Expired - Fee Related US6255554B1 (en) | 1994-09-13 | 1999-03-04 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/262,017 Expired - Fee Related US6255554B1 (en) | 1994-09-13 | 1999-03-04 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
Country Status (8)
Country | Link |
---|---|
US (2) | US5880327A (en) |
EP (2) | EP1739170A3 (en) |
JP (2) | JPH10506013A (en) |
AT (1) | ATE321785T1 (en) |
CA (1) | CA2200610C (en) |
DE (1) | DE69534907T2 (en) |
ES (1) | ES2262143T3 (en) |
WO (1) | WO1996009377A1 (en) |
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US6183803B1 (en) | 1999-06-11 | 2001-02-06 | Biosante Pharmaceuticals, Inc. | Method for processing milk |
WO2001011952A1 (en) * | 1999-08-19 | 2001-02-22 | Us Transgenics, Inc. | Transgenic prothrombin and related thrombin precursors and transgenics, methods, compositions, uses and the like relating thereto |
WO2001019846A1 (en) * | 1999-09-17 | 2001-03-22 | Genzyme Transgenics Corporation | Transgenically produced fusion proteins |
WO2001045730A2 (en) | 1999-12-20 | 2001-06-28 | Immunex Corporation | Tweak receptor |
US6255554B1 (en) * | 1994-09-21 | 2001-07-03 | American National Red Cross | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
WO2002072023A2 (en) * | 2001-03-12 | 2002-09-19 | Progenetics Llc | Production of high levels of transgenic factor viii with engineered stability, and its therapeutic uses |
US6518482B2 (en) | 1994-09-13 | 2003-02-11 | American National Red Cross | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
WO2003013244A1 (en) | 2001-08-03 | 2003-02-20 | The Government Of The United State Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Oral treatment of hemophilia |
US20030046716A1 (en) * | 2000-06-19 | 2003-03-06 | Yann Echelard | Transgenically produced platelet derived growth factor |
US20030159165A1 (en) * | 1997-12-19 | 2003-08-21 | Wyeth | Transgenic animal model for degenerative diseases of cartilage |
WO2003089620A2 (en) | 2002-04-19 | 2003-10-30 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US20040062752A1 (en) * | 1999-10-12 | 2004-04-01 | The University Of North Carolina At Chapel Hill | Adeno-associated virus vectors encoding factor VIII and methods of using the same |
US20040117863A1 (en) * | 1998-09-18 | 2004-06-17 | Edge Michael D. | Transgenically produced fusion proteins |
US20040117862A1 (en) * | 2002-03-11 | 2004-06-17 | Cooper Julian D. | Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses |
WO2004090099A2 (en) | 2003-04-04 | 2004-10-21 | Diversa Corporation | Pectate lyases, nucleic acids encoding them and methods for making and using them |
WO2005021714A2 (en) | 2003-08-11 | 2005-03-10 | Diversa Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
WO2006009676A2 (en) | 2004-06-16 | 2006-01-26 | Diversa Corporation | Compositions and methods for enzymatic decolorization of chlorophyll |
WO2006101584A2 (en) | 2005-03-15 | 2006-09-28 | Diversa Corporation | Cellulases, nucleic acids encoding them and methods for making and using them |
US20070011752A1 (en) * | 2005-05-06 | 2007-01-11 | American Integrated Biologics, Inc. | Production of human proteins in transgenic animal saliva |
WO2007095398A2 (en) | 2006-02-14 | 2007-08-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
US20070265199A1 (en) * | 2003-12-03 | 2007-11-15 | Fay Philip J | Recombinant Factor VIII Having Increased Specific Activity |
US20080010692A1 (en) * | 2006-07-06 | 2008-01-10 | Duke University | Mammals carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase |
WO2008036916A2 (en) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
WO2008036863A2 (en) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US7378078B2 (en) | 2000-12-13 | 2008-05-27 | The Regents Of The University Of Michigan | Compositions and methods for detecting proteolytic activity |
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US20090019555A1 (en) * | 2003-05-30 | 2009-01-15 | The University Of North Carolina | Animal model for chronic obstructive pulmonary disease and cystic fibrosis |
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US20090118184A1 (en) * | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
WO2009088949A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
US20090235369A1 (en) * | 2007-12-31 | 2009-09-17 | Baxter Healthcare S.A. | Transgenic Non-Human Animals Expressing Human Blood Clotting Factors and Uses Thereof |
EP2112227A1 (en) | 2006-03-07 | 2009-10-28 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
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US20100305305A1 (en) * | 2007-08-30 | 2010-12-02 | Lfb-Biotechnologies | Method for purifying factor viii and von willebrand factor |
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US7208576B2 (en) | 1999-01-06 | 2007-04-24 | Merrimack Pharmaceuticals, Inc. | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof |
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FR2983212A1 (en) | 2011-11-28 | 2013-05-31 | Lfb Biotechnologies | ANTI-FH APTAMERS, PROCESS FOR OBTAINING THEM AND USES THEREOF |
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CN104313052A (en) * | 2014-10-29 | 2015-01-28 | 上海滔滔转基因工程股份有限公司 | Mammary gland specific co-expression vector for stably expressing human coagulation factor VIII by utilizing vWF |
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DE4435485C1 (en) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Process for obtaining high-purity von Willebrand factor |
-
1994
- 1994-09-21 US US08/308,518 patent/US5880327A/en not_active Expired - Lifetime
-
1995
- 1995-09-21 ES ES95933128T patent/ES2262143T3/en not_active Expired - Lifetime
- 1995-09-21 CA CA2200610A patent/CA2200610C/en not_active Expired - Fee Related
- 1995-09-21 DE DE69534907T patent/DE69534907T2/en not_active Expired - Lifetime
- 1995-09-21 WO PCT/US1995/011781 patent/WO1996009377A1/en active IP Right Grant
- 1995-09-21 JP JP8510993A patent/JPH10506013A/en not_active Withdrawn
- 1995-09-21 EP EP06006431A patent/EP1739170A3/en not_active Withdrawn
- 1995-09-21 AT AT95933128T patent/ATE321785T1/en active
- 1995-09-21 EP EP95933128A patent/EP0807170B1/en not_active Expired - Lifetime
-
1999
- 1999-03-04 US US09/262,017 patent/US6255554B1/en not_active Expired - Fee Related
-
2009
- 2009-08-18 JP JP2009188810A patent/JP2010017184A/en not_active Withdrawn
Patent Citations (8)
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US6255554B1 (en) | 2001-07-03 |
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