US5851759A - Heteroduplex tracking assay (HTA) for genotyping HCV - Google Patents
Heteroduplex tracking assay (HTA) for genotyping HCV Download PDFInfo
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- US5851759A US5851759A US08/634,797 US63479796A US5851759A US 5851759 A US5851759 A US 5851759A US 63479796 A US63479796 A US 63479796A US 5851759 A US5851759 A US 5851759A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/113—Heteroduplex formation
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Abstract
Description
TABLE 1 __________________________________________________________________________ HCV 5'→3' nt 3'→5' nt ˜aa PCR __________________________________________________________________________ 1 SEQ ID NO:1 508-529 ˜170-176 universal I CCTGGTTGCTCTTTCTCTATCT sense #, purified,C170S probe 1 SEQ ID NO:2 1032- 1012- 338-344 Type 1 I GATGGCTTGTGGGATCCGGAG 1012 1032 antisense #, purified,E338A1 1 SEQ ID NO:3 1032- 1012- "Type 2a I GATGACCTCGGGGACGCGCAT 1012 1032 antisense #, purified,E338A2a 1 SEQ ID NO:4 1032- 1012- "Type 2b I GACCAGTTCTGGAACACGAGC 1012 1032 antisense #, purified,E338A2b 1 SEQ ID NO:5 1032- 1012- "Type 3a II CAAGGTCTGGGGTAAACGCAG 1012 1032 antisense #, purified,E338A3a 1 SEQ ID NO:6 978-958 958-978 ˜320-326 universal II CCAGTTCATCATCATATCCCA antisense #, purified,E320A 1 SEQ ID NO:7 536-557 " ˜179-186Type 1 II TGGCCCTGCTCTCTTGCTTGAC sense #, purified,C179S1 1 SEQ ID NO:8 536-557 " "Type 2 II TTGCTCTTCTGTCGTGCGTCAC sense #, purified,C179S2 1 SEQ ID NO:9 536-557 " "Type 3 II TTGCTCTGTTCTCTTGCTTAAT sense #, purified, C179S3 __________________________________________________________________________
TABLE 2 ______________________________________ Comparison of Partial E1 HTA and RFLP Genotyping Results Patient HTA RFLP ______________________________________ 12 1b 1b3 1b 1b4 3a 3a1b 1b 718 3a 3a20 3a 3a22 3a 3a3a 3a 23 2?*2a 241b 1b 263a 3a 281b 1b 30 2?* 2a 33 2?* 2a 353a 3a ______________________________________ *sample is neither 2a nor 2b
__________________________________________________________________________ SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 52 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: CCTGGTTGCTCTTTCTCTATCT22 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: GATGGCTTGTGGGATCCGGAG21 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: GATGACCTCGGGGACGCGCAT21 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GACCAGTTCTGGAACACGAGC21 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: CAAGGTCTGGGGTAAACGCAG21 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: CCAGTTCATCATCATATCCCA21 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: TGGCCCTGCTCTCTTGCTTGAC22 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: TTGCTCTTCTGTCGTGCGTCAC22 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: TTGCTCTGTTCTCTTGCTTAAT22 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: AACTCAAGCATTGTGTATGAAGCGGCGGACATGATCATGCACACCCCCGGGTGCGTGCCA60 TGCGTCCGGGAGGGCAATCTCTCCCGCTGCTGGGTAGCGCTCACTCCCACGCTCGCGGCC120 AGAAACAGCAGCGTTCCTACTACGACAATACGACGCCATGTCGACTTGCTAGTAGGAGCG180 GCTGCTTTTTGCTCCGCCATGTACGTGGGGGACCTCTGCGGATCTATTTTCCTCGTCTCC240 CAACTGTTCACCTTCTCGCCCCGCCGGCATCATACAGTACAGGACTGCAATTGCTCGATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: AACTCAAGCATCGTGTATGAGGCAGCGGAAGTGATCATGCACATTCCCGGGTGCGTGCCC60 TGCGTTCGGGAGAGCAATCTCTCCCGCTGCTGGGTAGCGCTCACCCCCACACTCGCGGCC120 AGGAACAGCAGCGTCCCCACCACGACAATACGACGCCACGTCGACTTGCTCGTTGGGGCG180 GCTGCCTTCTGCTCCGCTATGTATGTGGGGGATCTCTGCGGATCTGTTTTCCTTGTCTCC240 CAACTGTTCACCTTTTCGCCTCGCCGGCATGAGACAGTACAGGACTGCAATTGTTCAATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: AACTCAAGCATAGTATATGAGGCAGCGGACATAATCATGCATACCCCCGGGTGCGTGCCC60 TGTGTTCGGGAGGTCAACTCCTCCCGCTGCTGGGCAGCGCTCACCCCTACGCTCGCGGCC120 AGGAACTCCAGCGTGCCCACTACGACAATACGACGCCACGTCGACTTGCTCGTTGGGGCG180 GCTGCTTTCTGCTCCGCTATGTACGTGGGGGATCTATGCGGATCTGTTCTACTTGTCTCT240 CAGCTGTTCACCTTCTCACCTCGCCGGCACGAGACAGTGCAGGACTGCAATTGTTCAATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: AACACGAGCATTGTGTATGAGGCAGCGGACTTGATCATGCACGTCCCCGGGTGCGTGCCC60 TGCGTTCGGGAGGGCAACTCCTCCCGATGCTGGGTAGCGCTCACTCCCACGATCGCGGCC120 AGGAACAGCAGTGTCCCCGTTACGACCATACGACGCCACGTCGATTTGCTCGTTGGGGCG180 GCTGCTCTTTGCTCCGCCATGTACGTGGGGGATCTCTGCGGATCTGTCTTCCTCGCTTCC240 CAGTTGTTCACTTTCTCGCCTCGCCAGCATCAGACGGTACAGGACTGCAACTGCTCAATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: AACTCAAGCATCGTGTATGAGGCGGCGGAAGTGATCATGCACATTCCTGGGTGCGTGCCC60 TGCGTTCGGGAGGGCGACTTCTCCCGCTGCTGGGTAGCGCTCACCCCCACACTCGCGGCC120 AGGAATAACAGCGTCCCCACTACGACAATACGACGCCACGTCGACTTGCTCGTTGGGGCG180 GCTGCCTTCTGCTCCGCTATGTACGTGGGGGATCTCTGCGGATCTGTTTTCCTTGTCTCC240 CAACTGTTCACCTTTTCGCCTCGCCGGCATGCGACAGTACAGGACTGCAATTGTTCAATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: AACTCGAGTATTGTGTACGAGGCGGCCGATGCCATCCTGCACACTCCGGGGTGCGTCCCT60 TGCGTTCGTGAGGGCAACGCCTCGAGGTGTTGGGTGGCGATGACCCCTACGGTGGCCACC120 AGGGATGGCAAACTCCCCGCGACGCAGCTTCGACGTCACATCGATCTGCTTGTCGGGAGC180 GCCACCCTCTGTTCGGCCCTCTACGTGGGGGACCTATGCGGGTCTGTCTTTCTTGTCGGC240 CAACTGTTCACCTTCTCTCCCAGGCGCCACTGGACGACGCAAGGTTGCAATTGCTCTATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: AACTCAAGTATTGTGTATGAGGCAGCGGACATGATCATGCACACCCCCGGGTGCGTGCCC60 TGCGTCCGGGAGAGTAATTTCTCCCGTTGCTGGGTAGCGCTCACTCCCACGCTCGCGGCC120 AGGAACAGCAGCATCCCCACCACGACAATACGACGCCACGTCGATTTGCTCGTTGGGGCG180 GCTGCTCTCTGTTCCGCTATGTACGTTGGGGATCTCTGCGGATCCGTTTTTCTCGTCTCC240 CAGCTGTTCACCTTCTCACCTCGCCGGTATGAGACGGTACAAGATTGCAATTGCTCAATC300 TATCCC306 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: AATGATAGCATTACCTGGCAACTCCAGGCTGCTGTCCTCCACGTCCCCGGGTGCGTCCCG60 TGCGAGAAAGTGGGGAATACATCTCGGTGCTGGATACCGGTCTCACCGAATGTGGCCGTG120 CAGCAGCCCGGCGCCCTCACGCAGGGCTTACGGACGCACATTGACATGGTTGTGATGTCC180 GCCACGCTCTGCTCCGCTCTTTACGTGGGGGACCTCTGCGGTGGGGTGATGCTTGCAGCC240 CAGATGTTCATTGTCTCGCCACAGCACCACTGGTTTGTGCAAGACTGCAATTGCTCCATC300 TACCCT306 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: AACAACAGCATCACCTGGCAGCTCACTGACGCAGTTCTCCATCTTCCTGGATGCGTCCCA60 TGTGAGAATGATAATGGCACCTTGCATTGCTGGATACAAGTAACACCCAACGTGGCTGTG120 AAACACCGCGGTGCGCTCACTCGTAGCCTGCGAACACACGTCGACATGATCGTAATGGCA180 GCTACGGCCTGCTCGGCCTTGTATGTGGGAGATGTGTGCGGGGCCGTGATGATTCTATCG240 CAGGCTTTCATGGTATCACCACAACGCCACAACTTCACCCAAGAGTGCAACTGTTCCATC300 TACCAA306 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 306 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: AATAGCAGTATTGTGTATGAGGCCGATGATGTCATTCTGCACACACCCGGCTGTGTACCT60 TGTGTCCAGGACGGCAATACATCTACGTGCTGGACCCCAGTGACACCTACAGTGGCAGTC120 AGGTACGTCGGAGCAACTACTGCTTCGATACGCAGTCATGTGGACCTATTAGTAGGCGCG180 GCCACGATGTGCTCTGCGCTCTACGTGGGTGATATGTGTGGGGCTGTCTTTCTCGTGGGA240 CAAGCCTTCACGTTCAGACCTCGACGCCATCAAACGGTCCAGACCTGTAACTGCTCGCTG300 TACCCA306 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: CGCAACTCCACGGGGCTTTACCACGTCACCAATGATTGCCCTAACTCGAGTATTGTGTAC60 GAGACGGCCGATGCCATCCTGCACACTCCGGGGTGCGTCCCTTGTGTTCGCGAGGGCAAC120 GCCTCGAGGTGTTGGGTGGCGATGACCCCTACGGTGGCCACCAGGGATGGCAAACTCCCC180 GCGACGCAGCTTCGACGTCACATCGATCTGCTTGTCGGGAGCGCCACCCTCTGTTCGGCC240 CTCTACGTGGGGGATCTGTGCGGGTCTGTCTTTCTTGTCGGCCAACTGTTTACCTTCTCT300 CCCAGGCGCCACTGGACGACGCAAGGTTGCAAT333 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: AAGAACACCAGCGACAGCTACATGGTGACCAATGACTGCCAAAATGACAGCATCACCTGG60 CAGCTTGAGGCTGCGGTCCTCCACGTCCCCGGGTGCGTCCCGTGCGAGAGAGTGGGAAAT120 ACATCTCGGTGCTGGATACCGGTCTCACCAAACGTGGCTGTGCGGCAGCCCGGCGCCCTC180 ACGCAGGGCTTGCGGACGCACATCGACATGATTGTGATGTCCGCCACGCTCTGCTCCGCT240 CTCTACGTGGGGGACCTCTGTGGCGGGATGATGCTCGCAGCCCAGATGTTCATCGTTTCG300 CCGCAGAACCACTGGTTCGTGCAGGAATGCAAT333 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: AGGAACATCAGTTCTAGCTACTACGCCACTAATGACTGCTCGAACAACAGCATCACCTGG60 CAGCTCACCAACGCAGTTCTCCACCTTCCCGGATGCGTCCCATGTGAGAATAATAATGGC120 ACCTTGCATTGCTGGATACAAGTAACACCTAATGTGGCCGTAAAACATCGCGGCGCACTC180 ACTCACAACCTGCGGACACATGTCGACATGATCGTAATGGCAGCTACGGTCTGTTCGGCC240 TTGTACGTAGGAGACGTGTGTGGGGCTGTGATGATTGTGTCTCAGGCCCTTATAATATCA300 CCAGAACACCATAACTTCACCCAAGAGTGCAAC333 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: AAGGACACCGGCGACTCCTACATGCCGACCAACGATTGCTCCAACTCTAGTATCGTTTGG60 CAGCTTGAAGGAGCAGTGCTTCATACTCCTGGATGCGTCCCTTGTGAGCGTACCGCCAAC120 GTCTCTCGATGTTGGGTGCCGGTTGCCCCCAATCTCGCCATAAGTCAACCTGGCGCTCTC180 ACTAAGGGCCTGCGAGCACACATCGATATCATCGTGATGTCTGCTACGGTCTGTTCTGCC240 CTTTATGTGGGGGACGTGTGTGGCGCGCTGATGCTGGCCGCTCAGGTCGTCGTCGTGTCG300 CCACAACACCATACGTTTGTCCAGGAATGCAAC333 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: AAAAACACCAGCATCTCCTATATGGCGACCAACGACTGCTCCAATTCCAGCATCGCTTGG60 CAGTTTGACGGCGCAGTGCTCCATACTCCTGGATGTGTCCCTTGCGAACGGACCGGCAAC120 GCGTCCCGGTGTTGGGTGCCGGTTGCCCCCAATGTGGCTATAAGACAACCCGGCGCCCTC180 ACTAAGGGCATACGAACGCACATTGATGTCATCGTAATGTCTGCTACGCTCTGTTCTGCC240 CTTTACGTGGGGGACGTGTGTGGTGCGCTGATGATTGCCGCTCAGGTCGTCATTGTGTCT300 CCGCAGCATCACCACTTTGTCCAGGACTGCAAT333 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: AAGAACACCAGCGACTCCTACATGGCGACTAACGACTGCTCTAACTCCAGCATCGTTTGG60 CAGCTTGAGGACGCAGTGCTCCATGTCCCTGGATGTGTCCCTTGTGAGAAGACTGGCAAT120 ACGTCTCGGTGCTGGGTGCCGGTTACCCCCAATGTGGCTACAAGTCAACCCGGCGCTCTC180 ACCAGGGGCTTGCGGACGCACATCGATGTCATCGTGATGTCAGCCACGCTCTGCTCCGCT240 CTCTATGTGGGGGACGTGTGTGGCGCGTTGACGATAGCCGCTCAGGTTGTCATCGTATCG300 CCACGGCACCACCACTTTGTCCAGGACTGCAAT333 (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: AAGAACACCAGCACCTCCTACATGGTGACTAACGATTGCTCCAACTCCAGCATCGTTTGG60 CAACTTGAAGGCGCAGTGCTCCATGTTCCTGGATGTGTCCCTTGTGAGCAGATCGGCAAC120 GTGTCTCAGTGTTGGGTGCCGGTTACCCCCAATATGGCCATAAGTACACCCGGCGCTCTC180 ACTAAGGGCTTGCGAACGCACATCGACGGCATCGTGATGTCCGCTACGCTCTGTTCTGCC240 CTTTATGTGGGGGACGTGTGTGGCGCGTTGATGATAGCCGCCCAGGTCGTCATCGTATCG300 CCACAGCACCACCACTTTGTCCACGACTGCAAC333 (2) INFORMATION FOR SEQ ID NO:27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: CGCAACTCCACGGGGCTTTACCACGTCACCAATGATTGCCCTAACTCGAGTATTGTGTAC60 GAGGCGGCCGATGCCATCCTGCACACTCCGGGGTGCGTCCCTTGCGTTCGTGAGGGCAAC120 GCCTCGAGGTGTTGGGTGGCGATGACCCCTACGGTGGCCACCAGGGATGGCAAACTCCCC180 GCGACGCAGCTTCGACGTCACATCGATCTGCTTGTCGGGAGCGCCACCCTCTGTTCGGCC240 CTCTACGTGGGGGACCTATGCGGGTCTGTCTTTCTTGTCGGCCAACTGTTCACCTTCTCT300 CCCAGGCGCCACTGGACGACGCAAGGTTGCAAT333 (2) INFORMATION FOR SEQ ID NO:28: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: CGCAACGTGTCCGGGATATACCATGTCACGAACGACTGCTCCAACTCAAGTATTGTGTAT60 GAGGCAGCGGACATGATCATGCACACCCCCGGGTGCGTGCCCTGCGTCCGGGAGAGTAAT120 TTCTCCCGTTGCTGGGTAGCGCTCACTCCCACGCTCGCGGCCAGGAACAGCAGCATCCCC180 ACCACGACAATACGACGCCACGTCGATTTGCTCGTTGGGGCGGCTGCTCTCTGTTCCGCT240 ATGTACGTTGGGGATCTCTGCGGATCCGTTTTTCTCGTCTCCCAGCTGTTCACCTTCTCA300 CCTCGCCGGTATGAGACGGTACAAGATTGCAAT333 (2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: AGGAACATTAGTTCTAGCTACTACGCCACTAATGATTGCTCAAACAACAGCATCACCTGG60 CAGCTCACTGACGCAGTTCTCCATCTTCCTGGATGCGTCCCATGTGAGAATGATAATGGC120 ACCTTGCATTGCTGGATACAAGTAACACCCAACGTGGCTGTGAAACACCGCGGTGCGCTC180 ACTCGTAGCCTGCGAACACACGTCGACATGATCGTAATGGCAGCTACGGCCTGCTCGGCC240 TTGTATGTGGGAGATGTGTGCGGGGCCGTGATGATTCTATCGCAGGCTTTCATGGTATCA300 CCACAACGCCACAACTTCACCCAAGAGTGCAAC333 (2) INFORMATION FOR SEQ ID NO:30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30: CGGAATACGTCTGGCCTCTACGTCCTTACCAACGACTGTTCCAATAGCAGTATTGTGTAT60 GAGGCCGATGATGTCATTCTGCACACACCCGGCTGTGTACCTTGTGTCCAGGACGGCAAT120 ACATCTACGTGCTGGACCCCAGTGACACCTACAGTGGCAGTCAGGTACGTCGGAGCAACT180 ACTGCTTCGATACGCAGTCATGTGGACCTATTAGTAGGCGCGGCCACGATGTGCTCTGCG240 CTCTACGTGGGTGATATGTGTGGGGCTGTCTTTCTCGTGGGACAAGCCTTCACGTTCAGA300 CCTCGACGCCATCAAACGGTCCAGACCTGTAAC333 (2) INFORMATION FOR SEQ ID NO:31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 333 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31: AAGAACATCAGTACCGGCTACATGGTGACCAACGACTGCACCAATGATAGCATTACCTGG60 CAACTCCAGGCTGCTGTCCTCCACGTCCCCGGGTGCGTCCCGTGCGAGAAAGTGGGGAAT120 ACATCTCGGTGCTGGATACCGGTCTCACCGAATGTGGCCGTGCAGCAGCCCGGCGCCCTC180 ACGCAGGGCTTACGGACGCACATTGACATGGTTGTGATGTCCGCCACGCTCTGCTCCGCT240 CTTTACGTGGGGGACCTCTGCGGTGGGGTGATGCTTGCAGCCCAGATGTTCATTGTCTCG300 CCACAGCACCACTGGTTTGTGCAAGACTGCAAT333 (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCCAATAACATTATTGTGTATGAGGCCGATGACGTCATCCTGCACACGCCCGGCTG120 TGTACCTTGTGTTCAGGACGGTAATACATCCAAGTGCTGGACCCCAGTGACACCTACAGT180 GGCAGTCAGGTACGTCGGAGCAACCACCGCTTCAATACGCAGCCACGTGGACCTATTATT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCCAATAACATCATTGTGTATGAGGCCGATGACGTCATCCTGCACGCACCCGGCTG120 TGTACCTTGTGTTCAGGACGGCAATACATCCACGTGCTGGACCCCAGTGACACCTACAGT180 GGCAGTCAGGTACGTCGGAGCAACCACCGCTTCAATACGCAGCCATGTGGACCTATTAGT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCCAATAATATTATTGTGTATGAGGCCGACGACGTCATCCTGCACGCCCCCGGCTG120 TGTACCTTGTGTTCAGGACGGCAATACATCCACGTGCTGGATCCCAGTGACACCTACAGT180 GGCAGTCAGGTACGCCGGAGCAACCACCGCTTCAATACGCAGCCATGTGGACCTGTTAGT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCCAATAACATTATTGTGTATGAGGCCGATGACGTCATCCTGCACACACCCGGCTG120 TGTACCTTGTGTTCAGGACGGCAATACATCCACGTGCTGGACCCCAGTGACACCTACAGT180 ATCAGTCAGGTACGTCGGAGCAACCACCGCTTCAATACGCAGCCATGTGGACCTACTATT240 GGGCGCGGCCACGATGTGCTCCGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCCAATAACAGTATTGTGTATGAGGCCGATCACGTCATCCTGCACACACCCGGCTG120 TGTACCTTGTGTTCAAGCCAACAATAAATCCAAATGCTGGACCCCAGTGACACCTACAGT180 ATCAGTCGAGTACGTCGGAGCAACCACCGCTTCAATACGCAGCCATGTGGACCTACTATT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTTACCAACGA60 CTGTTCTAATAACATTATTGTGTATGAGGCCGATGACGTCATCCTGCACACACCCGGCTG120 TGTACCTTGTGTTCAGGACGGCAATGCATCCACGTGCTGGACCCCAGTAACACCTACAGT180 ATCAGTCAGGTACGTCGGAGCAACCACCGCTTCAGTACGCAGCCATGTGGACCTACTATT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTATGTGGGT277 (2) INFORMATION FOR SEQ ID NO:38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: TCATCCAACATCTAGTCTAGAGTGGCGGAATACGTCTGGCCTCTATGTCCTCACCAACGA60 CTGTTCCAACAACATTATTGTGTATGAGGCCGATGACGTCATTCTGCACACGCCCGGCTG120 CGTACCTTGTGTACAGGACGGCAATACATCCACGTGCTGGACCCCAGTGACACCTACAGT180 GGCAGTCAGGTACGTCGGAGCAACTACCGCTTCAATACGCAGCCATGTGGACCTATTATT240 GGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: TCATCCAGCAGCCAGTCTAGAGTGGCGGAATACGTCTGGCCTCTACGTCCTTACCAACGA60 CTGTTCCAATAGCAGTATTGTGTATGAGGCCGATGATGTCATTCTGCACACACCCGGCTG120 TGTACCTTGTGTCCAGGACGGCAATACATCTACGTGCTGGACCCCAGTGACACCTACAGT180 GGCAGTCAGGTACGTCGGAGCAACTACTGCTTCGATACGCAGTCATGTGGACCTATTAGT240 AGGCGCGGCCACGATGTGCTCTGCGCTCTACGTGGGT277 (2) INFORMATION FOR SEQ ID NO:40: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40: TGTGCCCGCTTCGGCCTACCAAGTGCGCAACTCCACGGGGCTTTACCACGTCACCAATGA60 TTGCCCTAACTCGAGTATTGTGTACGAGGCGGCCGATGCCATCCTGCACACTCCGGGGTG120 CGTCCCTTGCGTTCGTGAGGGCAACGCCTCGAGGTGTTGGGTGGCGATGACCCCTACGGT180 GGCCACCAGGGATGGCAAACTCCCCGCGACGCAGCTTCGACGTCACATCGATCTGCTTGT240 CGGGAGCGCCACCCTCTGTTCGGCCCTCTACGTGGGG277 (2) INFORMATION FOR SEQ ID NO:41: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: CATCCCAGCTTCCGCTTACGAGGTGCGCAACGTGTCCGGGATATACCATGTCACGAACGA60 CTGCTCCAACTCAAGTATTGTGTATGAGGCAGCGGACATGATCATGCACACCCCCGGGTG120 CGTGCCCTGCGTCCGGGAGAGTAATTTCTCCCGTTGCTGGGTAGCGCTCACTCCCACGCT180 CGCGGCCAGGAACAGCAGCATCCCCACCACGACAATACGACGCCACGTCGATTTGCTCGT240 TGGGGCGGCTGCTCTCTGTTCCGCTATGTACGTTGGG277 (2) INFORMATION FOR SEQ ID NO:42: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: CACCCCGGTCTCCGCTGCCGAAGTGAAGAACATCAGTACCGGCTACATGGTGACCAACGA60 CTGCACCAATGATAGCATTACCTGGCAACTCCAGGCTGCTGTCCTCCACGTCCCCGGGTG120 CGTCCCGTGCGAGAAAGTGGGGAATACATCTCGGTGCTGGATACCGGTCTCACCGAATGT180 GGCCGTGCAGCAGCCCGGCGCCCTCACGCAGGGCTTACGGACGCACATTGACATGGTTGT240 GATGTCCGCCACGCTCTGCTCCGCTCTTTACGTGGGG277 (2) INFORMATION FOR SEQ ID NO:43: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 277 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: AGTGCCAGTGTCTGCAGTGGAAGTCAGGAACATTAGTTCTAGCTACTACGCCACTAATGA60 TTGCTCAAACAACAGCATCACCTGGCAGCTCACTGACGCAGTTCTCCATCTTCCTGGATG120 CGTCCCATGTGAGAATGATAATGGCACCTTGCATTGCTGGATACAAGTAACACCCAACGT180 GGCTGTGAAACACCGCGGTGCGCTCACTCGTAGCCTGCGAACACACGTCGACATGATCGT240 AATGGCAGCTACGGCCTGCTCGGCCTTGTATGTGGGA277 (2) INFORMATION FOR SEQ ID NO:44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGCCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCGGGAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGCCCGGTCATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGCCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTACCGGAAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGTCCGGTCATTTGGGCACGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACC120 GGGTCCTTTCTTGGATCAACCCGCTCAATGCCTGGAGATTTGGGCGTGCCCCCGCGAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACC120 GGGTCCTTTCTTGGATCAACCCGCTCAATGCCTGGAGATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: GCGGAAAGCGCCTAGCCATGGCGTTAGTACGAGTGTCGTGCAGCCTCCAGGACCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATCGCTGGGGTGACC120 GGGTCCTTTCTTGGAGCAACCCGCTCAATACCCAGAAATTTGGGCGTGCCCCCGCGAGAT180 CACTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGCCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCGGGAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGCCCGGCCATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGCCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCGGGAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGCCCGGCCATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGCCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGCCTGGCCATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 (2) INFORMATION FOR SEQ ID NO:52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52: GCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGTCCCCCCCT60 CCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCGGGAAGACT120 GGGTCCTTTCTTGGATAAACCCACTCTATGCCCGGCCATTTGGGCGTGCCCCCGCAAGAC180 TGCTAGCCGAGTAG194 __________________________________________________________________________
Claims (23)
Priority Applications (11)
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US08/634,797 US5851759A (en) | 1996-04-19 | 1996-04-19 | Heteroduplex tracking assay (HTA) for genotyping HCV |
PCT/US1997/006062 WO1997040190A1 (en) | 1996-04-19 | 1997-04-11 | Heteroduplex tracking assay (hta) for genotyping hcv |
EP97920354A EP0904406B1 (en) | 1996-04-19 | 1997-04-11 | Heteroduplex tracking assay (hta) for genotyping hcv |
JP9538130A JP2000508907A (en) | 1996-04-19 | 1997-04-11 | Heteroduplex tracking assay (HTA) for genotyping HCV |
ES97920354T ES2297857T3 (en) | 1996-04-19 | 1997-04-11 | TRIAL TRIAL OF HETERODUPLEX (HTA) TO ESTABLISH THE HCV GENOTYPE. |
DE69738419T DE69738419T2 (en) | 1996-04-19 | 1997-04-11 | ASSAY PROCEDURE FOR SEARCHING HETERODUPLEXER DNA (HTA) FOR THE GENOTYPIZATION OF HCV |
AT97920354T ATE382093T1 (en) | 1996-04-19 | 1997-04-11 | TEST METHODS FOR SEARCHING HETERODUPLEX DNA (HTA) FOR GENOTYPING HCV |
CA002251673A CA2251673C (en) | 1996-04-19 | 1997-04-11 | Heteroduplex tracking assay (hta) for genotyping hcv |
JP2006322590A JP2007068542A (en) | 1996-04-19 | 2006-11-29 | Heteroduplex tracking assay (hta) for genotyping hcv |
JP2008105151A JP2008228736A (en) | 1996-04-19 | 2008-04-14 | Heteroduplex tracking assay (hta) for genotyping hcv |
JP2011256583A JP2012080890A (en) | 1996-04-19 | 2011-11-24 | Heteroduplex tracking assay (hta) for genotyping hcv |
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Application Number | Priority Date | Filing Date | Title |
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US08/634,797 US5851759A (en) | 1996-04-19 | 1996-04-19 | Heteroduplex tracking assay (HTA) for genotyping HCV |
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US5851759A true US5851759A (en) | 1998-12-22 |
Family
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US08/634,797 Expired - Lifetime US5851759A (en) | 1996-04-19 | 1996-04-19 | Heteroduplex tracking assay (HTA) for genotyping HCV |
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US (1) | US5851759A (en) |
EP (1) | EP0904406B1 (en) |
JP (4) | JP2000508907A (en) |
AT (1) | ATE382093T1 (en) |
CA (1) | CA2251673C (en) |
DE (1) | DE69738419T2 (en) |
ES (1) | ES2297857T3 (en) |
WO (1) | WO1997040190A1 (en) |
Cited By (10)
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EP1201770A2 (en) * | 2000-10-30 | 2002-05-02 | Tosoh Corporation | Oligonucleotide for highly sensitive detection of hepatitis c virus and method for detection thereof |
WO2003057915A2 (en) * | 2002-01-11 | 2003-07-17 | University Of Southampton | Methods of detecting hcv genotype 1 (hcv-1) by using primers specific for the 5’ non-coding region (ncr) of the hcv genome |
US20030152942A1 (en) * | 2001-05-09 | 2003-08-14 | Lance Fors | Nucleic acid detection in pooled samples |
US20030201764A1 (en) * | 2002-04-26 | 2003-10-30 | Jafari Nasser Ali | Unified apparatus and method to assure probe card-to-wafer parallelism in semiconductor automatic wafer test, probe card measurement systems, and probe card manufacturing |
EP1379690A1 (en) * | 2001-04-12 | 2004-01-14 | Biocore Co. Ltd. | Oligonucleotide chip composition for analyzing hepatitis c virus (hcv) genotype and detecting method thereof |
US20040121318A1 (en) * | 2000-09-26 | 2004-06-24 | Sean Philpott | Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients |
US20050005312A1 (en) * | 1999-11-02 | 2005-01-06 | Wu George Y. | Propagation of human hepatocytes in non-human animals |
US20060194227A1 (en) * | 2000-09-26 | 2006-08-31 | Sean Philpott | Heteroduplex tracking assay |
WO2007084568A2 (en) | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Heteroduplex tracking assay |
US20080020370A1 (en) * | 2000-09-26 | 2008-01-24 | Sean Philpott | Heteroduplex tracking assay |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2003523732A (en) | 1999-06-25 | 2003-08-12 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー | Binding of multi-zinc finger transcription factor to nucleic acid |
US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
WO2008131283A1 (en) * | 2007-04-18 | 2008-10-30 | Pathway Diagnostics Corporation | Single-stranded dna probe heteroduplex tracking assays |
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- 1997-04-11 AT AT97920354T patent/ATE382093T1/en active
- 1997-04-11 ES ES97920354T patent/ES2297857T3/en not_active Expired - Lifetime
- 1997-04-11 JP JP9538130A patent/JP2000508907A/en not_active Withdrawn
- 1997-04-11 WO PCT/US1997/006062 patent/WO1997040190A1/en active IP Right Grant
- 1997-04-11 DE DE69738419T patent/DE69738419T2/en not_active Expired - Lifetime
- 1997-04-11 EP EP97920354A patent/EP0904406B1/en not_active Expired - Lifetime
- 1997-04-11 CA CA002251673A patent/CA2251673C/en not_active Expired - Lifetime
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2006
- 2006-11-29 JP JP2006322590A patent/JP2007068542A/en not_active Withdrawn
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2008
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DE69738419T2 (en) | 2008-12-18 |
ATE382093T1 (en) | 2008-01-15 |
EP0904406B1 (en) | 2007-12-26 |
CA2251673A1 (en) | 1997-10-30 |
CA2251673C (en) | 2005-10-25 |
WO1997040190A1 (en) | 1997-10-30 |
ES2297857T3 (en) | 2008-05-01 |
JP2008228736A (en) | 2008-10-02 |
EP0904406A1 (en) | 1999-03-31 |
JP2000508907A (en) | 2000-07-18 |
DE69738419D1 (en) | 2008-02-07 |
JP2012080890A (en) | 2012-04-26 |
JP2007068542A (en) | 2007-03-22 |
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