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Publication numberUS4951653 A
Publication typeGrant
Application numberUS 07/163,260
Publication date28 Aug 1990
Filing date2 Mar 1988
Priority date2 Mar 1988
Fee statusPaid
Also published asCA1334596C, DE68923557D1, DE68923557T2, DE68927273D1, DE68927273T2, EP0425495A1, EP0425495A4, EP0425495B1, EP0596513A1, EP0596513B1, WO1989007907A1
Publication number07163260, 163260, US 4951653 A, US 4951653A, US-A-4951653, US4951653 A, US4951653A
InventorsFrancis J. Fry, Narendra T. Sanghvi
Original AssigneeLaboratory Equipment, Corp.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Ultrasound brain lesioning system
US 4951653 A
Abstract
An ultrasound brain lesioning system with ultrasound, CT or MRI site localization includes a skull fixation apparatus, a position data translating fixture and a computer-controlled ultrasound transducer. The skull fixation apparatus is utilized in combination with ultrasound, CT or MRI scan transparencies and with a digitizing tablet in order to transfer transparency data both as to skull fixation benchmarks and tumor locations into a computer. The transducer is cooperatively arranged with the translating system such that the benchmarks of the skull fixation apparatus are utilized to derive X, Y and Z linear coordinates and two rotary coordinates which are at right angles to one another which are also input into the computer such that the computer is then capable of automatically driving the transducer and positioning it at the appropriate location for producing volume lesions in the brain at the site of the identified brain tumors or other selected tissues.
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Claims(8)
What is claimed is:
1. A non-invasive ultrasound treatment system for translating visualization data of a diseased site in a patient into movement data for guiding an ultrasound transducer relative to said diseased site for treatment thereof, said ultrasound apparatus comprising:
transducer control means for an ultrasonic transducer moving said ultrasound transducer relative to said diseased site;
data transfer means for converting visualization data of the diseased site into spatial coordinate data and placing said spatial coordinate data into said transducer control means;
fixation means adapted to be attached to the patient and including landmark reference elements, said fixation means enabling a spatial relationship between said patient and said reference elements to be established; and
spatial translation means coupled to said transducer control means and designed and arranged for contacting with said landmark reference elements for establishing a spatial frame of reference for said ultrasound transducer relative to said patient and in turn relative to said diseased site.
2. The ultrasound treatment system of claim 1 wherein said transducer control means includes mechanical drive arrangements including drive motors and a computer means for controlling the drive motors.
3. The ultrasound treatment system of claim 2 wherein said data transfer means includes a digitizing tablet.
4. The ultrasound treatment system of claim 3 wherein said landmark reference elements include a plurality of spherical members.
5. The ultrasound treatment system of claim 4 wherein said spatial translation means includes mechanical linkage means designed and arranged for recording positional movement and including linear and rotary encoders.
6. The ultrasound treatment system of claim 1 wherein said data transfer means includes a digitizing tablet.
7. The ultrasound treatment system of claim 1 wherein said landmark reference elements include a plurality of spherical members.
8. The ultrasound treatment system of claim 1 wherein said spatial translation means includes mechanical linkage means designed and arranged for recording positional movement and including linear and rotary encoders.
Description
BACKGROUND OF THE INVENTION

The present invention relates in general to brain lesioning methods and apparata. More particularly, the present invention relates to a combination system for brain lesioning which initially uses a separate visualization system for site localization. The data from the visualization system is digitized and translated by computer into linear and rotary positioning means for positioning the ultrasound transducer which is used to create volume lesions. The separate visualization system may be a CT or MRI scan or may be ultrasonic imaging. The required output in the depicted configuration is a transparency of the imaged tumor or other volume to be lesioned which can then be translated into a computer by use of a digitizing tablet.

Traditionally, the selected method for treatment of brain tumors and related disorders was to first take and process an X-ray film of the brain and from that film roughly determine the size, shape and location of the tumor. The next step was to surgically remove as much of the tumor as possible. As technology has advanced, X-ray usage has yielded to other visualization methods, such as ultrasound, CT scan techniques and MRI utilization. The surgical procedures have expanded to cryoknives and gamma knives. Radon seeds have been implanted and ionizing radiation used. Each of these approaches has met with some success but not without their share of adverse side effects, including incomplete treatment.

Any cutting procedure is risky, especially in the area of the brain, in that the procedure may result in the incomplete removal of the tumor tissue, the excess removal of healthy tissue, or both. Ionizing radiation creates a cumulative effect of the dosage to the other, surrounding brain tissue. These concerns and their attendant problems are addressed and solved by the use of ultrasound to produce volume lesions in the brain. As is well known, the noninvasive nature of ultrasound provides a safe and convenient means of treatment by selection of a suitable dosage to produce volume lesions.

The success of any ultrasound approach depends on a number of factors. Not only must the dosage (intensity and time) be controlled, but the alignment of the beam, spot size and completeness of the treatment over the full volume of the tumor or other selected tissues are critical. An added concern with the treatment of brain tumors with ultrasound is the risk of "skimming" of the ultrasound beam by the edge of the bony opening in the skull. Finally, since ultrasound is not a "sighted" treatment technique, the physician needs to have some means of determining the exact location of the tumor, its size and its shape.

The number of engineering and anatomical concerns over the use of ultrasound for treatment of brain tumors has meant that over the years there has been very little interest in producing volume lesions in the brain for the elimination of tumors. The inability to deal with these engineering and anatomical concerns has meant that a valuable treatment option has not been adequately utilized. There is no doubt that noninvasive ultrasound is preferred over the surgeon's scalpel. What has been missing and what is provided by the present invention is a means to translate the tumor location and shape determination data from a reliable imaging technique such as ultrasound, CT scan or MRI into computer-controlled linear and rotary drive means for the ultrasound transducer. By digitizing the ultrasound, CT scan or MRI data, alignment of the focused ultrasound beam can be precise and the dosage determined so as to be able to use ultrasound to produce volume lesions in the brain for the treatment of tumors. The present invention provides a number of unique and valuable structures which cooperate to provide an apparatus which is both extremely accurate and precise, and which avoids the prior art problems.

SUMMARY OF THE INVENTION

An apparatus for treatment of brain tumors or other selected brain tissues according to one embodiment of the present invention includes a skull fixation apparatus which incorporates a plurality of alignment spheres, a movable translation assembly which includes a precision ball for providing linear and rotary positioning data by way of a cup which is adapted to fit over the plurality of spheres, a linear encoder which cooperatively interfaces with the precision ball for deriving X, Y and Z linear positioning data, a pair of rotary encoders which cooperatively interface with the precision ball for deriving rotary positioning data, digitizing means for deriving skull fixation coordinates and tumor data from an image transparency produced by a suitable imaging or scan technique, computer means which cooperatively interface with the digitizing means for retrieving and storing skull fixation coordinates and tumor data from the imaging or scanner means, and wherein the computer means is operatively coupled to the linear encoder and to the pair of rotary encoders for receiving linear and rotary positioning data and which is operable to automatically move the transducer in both linear and rotary directions such that the focused beam of ultrasound from the transducer is able to be directed at the locations of the brain tumors.

A method of transforming spatial geometry into a radiation system for treatment of brain tumors according to another embodiment of the present invention comprises the steps of placing the patient into a skull fixation device, applying spatial coordinate landmarks to the skull fixation device, producing image data of the patient's skull and any brain tumor including image data of the spatial coordinate landmarks, transferring the image data and the spatial coordinate landmarks to the digitizing means, positioning the patient in an ultrasound treatment apparatus with the skull fixation device attached, modifying the skull fixation device by adding reference landmarks, coupling coordinate translating means to the reference landmarks for deriving linear and rotary coordinate positions of the reference landmarks to the skull fixation device, processing the image data and the derived coordinates of the reference landmarks into transducer movement data for directing the movement of the treatment transducer, and generating volume lesions by ultrasound into any brain tumor.

One object of the present invention is to provide an improved method and apparatus for generating volume lesions in the brain by focused ultrasound.

Related objects and advantages of the present invention will be apparent from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a diagrammatic illustration of the main component parts and their relationship to one another according to a typical embodiment of the present invention.

FIG. 1A is a diagrammatical illustration of the patient positioned for initial imaging.

FIG. 2 is a diagrammatic illustration of positional data translating means comprising a portion of the present invention.

FIG. 2A is a perspective view of a skull fixation device with reference landmarks attached for spatial coordinates.

FIG. 3 is a front elevation, diagrammatic illustration in full section of the transducer design comprising a portion of the present invention.

FIG. 4 is a diagrammatic illustration of the focused ultrasound beam as directed into the brain tumor.

FIG. 5 is a diagrammatic illustration of the skull opening and centralizing of the ultrasound beam which is directed by the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENT

For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiment illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the illustrated device, and such further applications of the principles of the invention as illustrated therein being contemplated as would normally occur to one skilled in the art to which the invention relates.

Referring to FIG. 1, there is a diagrammatic illustration of the main portions of the present invention. The patient 10 is shown lying on table 11. As illustrated, the patient shown is lying on his side but it should be understood that the system permits any patient position, including even a sitting position. The skull 12 is shown attached to rigid skull fixation apparatus 13. Metal pins 14 are driven into the skull 12 for rigidly fixing the skull in position as is well known in the art. Although only two pins 14 are illustrated, a third pin is employed on somewhat equal radial spacing so as to suitably support the skull.

Prior to placing the patient in position for treatment by ultrasound irradiation apparatus 17, the patient has been subjected to some form of imaging technique as shown in FIG. 1A in order to generate brain site identification and localization data which will include the size, shape and location of any tumors and landmarks which establish a precise frame of reference and orientation for the patient. Imager 15 is representative of the suitable forms of imaging for the present invention, including ultrasound, CT scan or MRI with lines 15a and 15b being representative of information transmission lines for the image data and lines 15c being representative of the transmitted and/or received image signals. Regardless of the technique, external landmarks must be provided for precisely locating the skull features and tumors spatially relative to the fixation apparatus 13. The patient still with apparatus 13 attached is then placed in position for treatment by the ultrasound irradiation apparatus 17. As will be explained in greater detail hereinafter, a coordinate transformation is made from the coordinates in brain space as derived from the imaging data to brain space relative to the ultrasound irradiation apparatus for the computer controlled, automatic guiding and positioning of the ultrasound transducer it is thus important for apparatus 13 to remain fixed in position relative to the position of apparatus 17.

It is to be understood that while a number of significant advantages in the treatment of brain tumors are derived by the use of ultrasound, ultrasound is not a "sighted" technique and thus some means must be provided in order to precisely identify the location of the brain tumors or other brain sites as well as their size and geometry. Since these particular features and data can be derived from ultrasonic imaging or CT or MRI scans, one of those techniques is initially applied for subsequent use in practicing the present invention. However, simply having this data, whether in the form of transparencies or data signals derived from these scans is not sufficient unless coordinate landmarks are provided on the transparency or as part of the image data signals so that they can be used as a point or frame of reference for the ultrasound transducer. The translating of this imaging data from the scan transparency into the mechanical drive for the transducer is critical to the success of the present invention. However, if transparencies are not used, the image data signal is input directly into the computer. The referenced landmarks may take various forms but they need to have a specific, fixed and known position relative to fixation apparatus 13. The dimensional (coordinate) relationship can be programmed into the computer control to assist in position identification. Additionally, these landmarks must be visible on the image transparency, if that form of data entry is used, so that their position can be digitized and input into the computer.

Once the patient is in place, a steri drape cloth with a hole large enough to outline the edge of the scalp area of the ultrasound or radiation field is attached to the patient's scalp. The cloth is then drawn up through an open bottom in waterbath support 18 so that this plastic liner forms a water-tight container from the surface of the scalp to the top of the waterbath support. This waterbath support is actually supported above the patient's scalp and does not rest on the scalp.

A water degasser 19 (shown as a boiling unit) provides hot, degassed water through heat exchanger 20. The water output through heat exchanger 20 is controlled to the normal body temperature as waterbath support 18 is filled with degassed water 22. Heat exchanger 24 provides circulating water through coils and waterbath support 18 in order to maintain a fixed temperature for the degassed water 22. It should also be noted that the patient as illustrated has a lateral skull section removed which is done surgically at a previous time and the ultrasound irradiation is conducted through the hole in the scalp.

The generated transparencies, which will be the form of data entry described for the preferred embodiment, from either the ultrasonic imaging or by CT or MRI scans (and which include reference landmarks or benchmarks) are placed on digitizing tablet 27 which is back-illuminated. The digitizing tablet with either a light pen or similar data pick up and transferring means, such as a cursor, enables the physician or technician to locate the reference landmarks and to outline the various tumor areas. Also digitized is the bony opening in the skull so that its geometric center can be established. As should be well known by those of ordinary skill in the art, with a CT scan a plurality of transparencies are taken due to the multiple "slices" through the brain which must be derived in order to provide volume information. Thus, this digitizing step must be repeated for all of the CT transparencies for the particular patient such that when completed, there is total geometry data of the entirety of all tumors or other brain sites and those tumors are positioned relative to the referenced landmarks. All essential features of the brain sites, skull opening, reference landmarks are scanned on digitizing tablet 27 and all of this information is stored in computer 28.

From the transparencies which are outlined and transferred from digitizing tablet 27 to computer 28, all of the dimensional information is provided to the formulation for computing the voltage drive levels to all sites in order to give the necessary sound intensity at the selected brain sites. Since the brain volume selected for ablation is in general of a complex shape, this complexity is treated by a multiplicity of individual ultrasound lesions. The focal position for each of these individual ablation sites is selected by the computer 28 through preprogramming, and the transducer focus is automatically brought to the appropriate sites. The transducer 29 is provided with five degrees of freedom. There are three orthogonal motions through a normal XYZ coordinate system 30 and two rotational motions as illustrated by the arrows of rotation 30a and 30b.

The programming of computer 28 has been arranged so that for each individually selected lesion site, the central ray of the ultrasonic beam from transducer 29 passes generally through the geometric center of the skull opening so that beam "skimming" at the skull bone edge is avoided.

Power is provided to the transducer 29 from power amplifier 31. Amplifier 31 is driven by a low-level amplifier 32 with its frequency source. Impedance matching network 33 couples the amplifier 31 to transducer 29. Once the required acoustic output from transducer 29 is decided, the driving voltage to transducer 29 is computed by way of computer 28 which in turn sets the input in amplifier 32 so that the required voltage is set. Once set, the feedback loop from matching network 33 to amplifier 32 maintains this fixed voltage level. As an additional check on the voltage drive level to transducer 29, an additional absolute voltage readout is provided through oscilloscope 36.

Periodic monitoring of the sound output from transducer 29 is provided by the radiation force method. A bifilar suspension 37 mounted to tank 38 by support 39 suspends a stainless steel ball 40 in a temperature controlled and degassed volume of water 43 which is contained within tank 38. This water temperature is maintained by heat exchanger 24. The transducer 29 is brought into tank 38 by placing tank 38 in support 17 (without the patient in place). Coordinate system 30 (XYZ coordinates of linear motion) is a mechanical drive structure which is capable of moving transducer 29 so that the focal position of the generated ultrasound beam from transducer 29 impinges on the stainless steel ball 40.

Sound-absorbing material 44 which is mounted in tank 38 serves to suppress standing waves in tank 38 during the calibration procedure. Deflection of the stainless steel ball for a specified set of drive voltages into transducer 29 is recorded by the use of an optical telescope 45. Telescope 45 is mounted outside but attached to tank 38. Horizontal motion displacement of the stainless steel ball is recorded on micrometer 46. This ball deflection is directly related to the sound output intensity at the focal position in the sound field and this particular method is believed to be a primary standard for measuring sound field intensity.

Referring to FIGS. 2 and 2A, the apparatus for transformation of coordinates to the irradiation apparatus is illustrated. This transformation is accomplished by the use of a precision joystick apparatus 48 which is attached to the back of the housing for focusing transducer 29. This joystick apparatus includes member 49 which can be linearly translated by way of precision ball 50. Universal angular motion of member 49 is provided directly through precision ball 50. Attached to member 49 is cup 51 which includes a hemispherical concave surface that is designed and sized to fit precisely over each of the balls 52 (see FIG. 2A) which are added to and supported on skull fixation apparatus 13 by corresponding upright members 53. Each combination of member 53 and ball 52 is detachable but fits into precision holes which are bored into apparatus 13. As is appropriate for complete alignment, three ball and member combinations are added to skull fixation apparatus 13. The use of these three assemblies and the interlocking of each with cup 51 permits the complete transformation of coordinates into computer 28.

The patient is positioned within apparatus 13 and the alignment balls 52 are attached. Further apparatus 13 is rigidly affixed relative to the position 8 apparatus 17 at a known position such that as the cup 51 is moved into position over each ball 52, the position coordinates are derived relative to apparatus 17. As should be understood, each component used in this procedure has specific dimensions and points of attachment, all of which are known and programmed into the computer 28. The extrapolation is sequential, but not complicated. The free space coordinates of the alignment balls 52 is derived relative to the movement of transducer 29. These balls 52 have a fixed position (known) relative to fixation apparatus 13 and the fixation apparatus has a fixed position (known) relative to the brain tumor(s).

It should be noted that member 49 electrically interfaces with linear encoder 56 and two rotary encoders (polentiometers) 57 and 58, which are used to obtain rotation degrees. The two rotary encoders are positioned at right angles to each other. The coordinate translating system of FIGS. 2 and 2A builds upon the image data and landmarks previously digitized. This earlier derived information provides dimensional data and space coordinates regarding the size and shape of the brain tumor(s) and their location relative to the skull fixation apparatus 13. What is missing is the positional data of the ultrasound irradiation apparatus 17 relative to apparatus 13. Once the ball 52 and member 53 assemblies are installed into their precise locations on the fixation apparatus 13 these become the frame of reference for the transducer 29 positioning.

The X, Y and Z coordinates and the two degrees of rotary freedom for the transducer 29 at each position when the cup 51 is placed over each ball 52, once input into the computer 28, enables the transducer to be moved by computer control to each tumor position for volume lesioning. A key point to be noted is that no precise alignment is required in using this system. All that needs to be done is to position cup 51 in the proximity of each ball 52 so that the cup can be drawn over each ball for establishing the coordinates. This sequence of steps is repeated for a total of three sets of data for the complete transformation and while the system is extremely precise, it does not require any precise alignment.

Referring to FIG. 3, transducer 29 is illustrated in greater detail including several unique features which are provided in order for a stable acoustic output to be obtained at all preselected driving levels. These driving levels are required in order to produce controlled focal brain lesions in deep brain sites. In order to achieve this necessary objective, it is necessary to have a stable sound-producing source such as generally circular (disc) quartz plate 61 which is used in this particular embodiment. The quartz plate 61 is able to be maintained flat and parallel to generally circular, plano-concave lens 62 by the structure which will be described hereinafter. Lens 62 is a hard anodized aluminum lens with an elliptic concave surface for minimizing the half-intensity length of the beam at the focus. In order to maintain flatness and parallelism of plate 61 and lens 62 with a fixed spacing distance therebetween, the aluminum flat side of the lens is precisely machined flat with at least one 1/8-inch diameter rod 63 machined on the surface to extend a distance above the lens surface equal to a 1/4 wave length in the silicone oil 65 in space 66. A suitable silicone oil for this application is Dow Corning 710 fluid.

In order to maintain this 1/4 wave length spacing to within plus or minus 0.0001 inches, it is required that the outer peripheral lip 62a of aluminum lens 62 provide unanodized surfaces (flat top and bottom surfaces and outer edge surface) which rest directly in contact with the flat machined surface of housing 64 and end plate 64a. Housing 64 includes an inwardly and upwardly directed lip 64b, of an annular ring configuration, whose underside abuts against the top surface of lip 62a and whose top surface supports plate 61. The height of this lip is precisely machined since it is the means to fix the 1/4 wave length separation between the plate 61 and lens 62. Rod 63 provides center stabilizing for the plate due to its span between peripheral edge supports and the pressure differential between the top and bottom surfaces of the quartz plate. The space 66 between the plate 61 and lens 62 (the 1/4 wave length spacing) is filled with silicone oil 65 which is freely exchanged through radially open channels in lip 64b. Gasket 64c seals the oil in space 66.

One gold-plated and polished electrode (not shown) is electrically connected to quartz plate 61 and rests in direct contact with the top machined surface of lip 64b and provides the electrical ground contact for the quartz plate.

In order to keep plate 61 in pressure contact with housing 64, a flat, flexible compression gasket 71 is firmly pressed against plate 61 through metal member 72. In order to provide electrical contact for power to plate 61 another foil electrode 73 fabricated of an approximate 0.001 inches thick soft metal foil (gold, brass, silver) extends part-way under compression gasket 71, while the remainder of gasket 71 acts as a seal for the silicone oil. The power and ground electrodes on plate 61 do not extend to the edge of plate 61 and the silicone oil provides insulation around the edge. The foil electrode 73 is attached to metal member 72 with a series of metal screws 74.

To provide RF power to drive quartz plate 61 a coaxial cable 79, with a metal outer jacket 80 is used. Jacket 80 is cut and peeled back so as to place the cut, free end of jacket 80 between plates 81 and 82. Plates 81 and 82 are clamped together using mechanical fasteners in order to establish an electrical ground on jacket 80. The coaxial cable has an end plug 84 which side pressure contacts plate (metal member) 72 through a central hole. Space 85 is an air space so that the quartz plate 61 is not back acoustically loaded thereby directing all its acoustic output through the interspace 66 and lens 62 into the oil which is in front of lens 62. To insure flatness of quartz plate 61 and parallelism with the flat surface of lens 62, the air space 85 and all other air spaces in the transducer housing 64 are pressurized through tube 86 into element 87. This air pressure holds quartz plate 61 against machined rod 63 to maintain the necessary parallelism. Pressure is applied from source 88.

In order to maintain a positive differential pressure in space 85 relative to the pressure in interspace 66, flow communication is provided from interspace 66 via flow access channels 89 into column 90 and well 91. These areas are all silicone oil filled and in pressure equilibrium is a thin flexible diaphragm 92 which covers well 91. Above diaphragm 92, the air space 93 is exhausted through flexible tubing 94 and rigid tube 95 to the outside atmosphere.

A further feature to suppress cavitation in the oil in space 65 between the quartz plate 61 and lens 62 when the system is run at the highest acoustic output power is provided by pressure system 96 providing greater-than-atmospheric pressure to space 93. Typically this pressure will be that which prevents any cavitation in space 65 (of the order of 40-50 pounds per square inch). This pressure in space 93 is readily transmitted through diaphragm 92 to the silicone oil 65 in well 91 and hence through column 90 into space 66. The pressure provided by source 88 is in the order of 2 pounds per square inch higher than the pressure in system 96 in order to keep plate 61 flat and held against lens 62 through rod 63.

Element 99 in the transducer assembly is an insulating member to which element 72 is bolted by screw(s) 100. Gasket 101 keeps the silicone oil contained in column 90 from reaching the coaxial cable 79. Metal plate 82 is bolted to housing 64 around the outer periphery of plate 82. Oil is kept in column 90 and well 91 by the use of O-ring seal 103 positioned between housing 64 and plate 82 and by gasket 105. Member 106 is bolted and sealed to plate 82. Top metal plate 107 is bolted by screws 108 to housing 64 and sealed thereto through O-rings 109. Metal tube 95 is sealed to element 87 through seal 110. The coaxial cable 79 is water-tight and sealed to top plate 107 through member 111 and O-ring 112.

In order to accomplish the task of producing lesions of any complex size or shape in the human brain with intense focused ultrasound it is necessary to provide for ultrasound dosage conditions which produce individual focal lesions (from which the complex volume can be generated), which do not compromise brain tissue outside the intended focal lesions site and permit subsequent individual focal lesions in a contiguous manner. To do this in both gray and white matter and abnormal brain tissue, it is necessary to inhibit the production of microbubble formation at the primary focal site so that there can be no vascular dispersion of such microbubbles away from the primary focal site which microbubbles could initiate off primary site lesion production and hemorrhage due to ultrasound passage through tissue containing microbubbles.

In order to accomplish this task while being able to accomplish primary site lesions, it is necessary to derive these sound intensities as a function of frequency which will not produce microbubbles at the primary lesion site. This requires that for a 1 MHz sound frequency (a frequency necessary to achieve deep penetration into the human brain), the primary site sound intensity must not exceed 300 watts per square centimeter. At this intensity and for lower intensities, gray and white matter lesions on a multiplicity of individual contiguous sites can be produced without undesirable side effects (microbubbles). As the frequency is increased above 1 MHz, the primary site sound intensity can be increased and produce no microbubbles but the penetration capability in brain tissue returns as the sound frequency is increased. At 4 MHz frequency which is the upper frequency which can be considered for more superficial brain lesion production, the intensity which will not lead to microbubble formation is at least 2100 watts per square centimeter. At these intensity limits, the time-on period of sound irradiation at each individual site can be extended to as many seconds as is needed to ablate the tissue at the focal site without microbubble formation.

In order to constrict the individual lesion sites so that the boundaries of desired volume lesions can be constrained, the transducer configuration used will give a half intensity length at the lesion focal region in the order of 15 mm at 1 MHz operating frequency. This length of half intensity is consistent with the necessity of constraining lesions in the human brain so that the extending of individual lesions into white matter (white matter is more sensitive than gray matter) can also be constrained.

Referring to FIGS. 4 and 5, the details of the ultrasound being focused and central beam axis are shown with respect to the skull bone opening, the brain volume site to be lesioned and the tissue depth which is described in order to compute the tissue attenuation from the scalp surface to the brain volume selected to be lesioned.

Skull 116 with skull hole outline 117 is constructed (digitized) in computer 28 along with brain tissue volume 118 and scalp and muscle tissue 119. Prior information on individual brain lesion 120 dimensions along with preselection of the pattern in which the individual lesions 120 are to be produced, spacing of individual lesions to give the desired overlap in tissue boundary patterns are processed in the computer. Individual lesions 120 within volume 118 are irradiated along the central axis 121 of the beam with the axis programmed to pass through the skull opening 117 at the geometric center 124. As the transducer 29 changes orientation by computer control, the central axis will shift, but the focal point of the beam will be at the desired lesion site and the central axis will be close to the center 124.

Each individual lesion 120 within volume 118 has its distance computed along the transducer beam axis starting at the scalp surface 125, proceeding through the scalp and muscle 119 (distance A) through the brain tissue 126 (distance B). The scalp and muscle average attenuation coefficient and the brain attenuation coefficient along with dimensions A and B are involved in the computation of total acoustic beam loss. From these computations, the necessary driving voltage to transducer 29 is provided automatically for each individual lesion site 120 in brain tissue volume 118.

It is also possible in some cases to apply the above system and technique to the production of focal lesions in the brain through the intact scalp muscle and skull bone. In this circumstance, the attenuation factor for the skull must be entered as an additional attenuation and the central beam axis of transducer 29 held within plus or minus five degrees perpendicular to the skull surface on its path to each individual lesion site 120. Although this system is specifically designed for the brain, it can be used in the transcutaneous mode to produce lesions and other appropriate body tissues.

While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiment has been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3735755 *28 Jun 197129 May 1973Interscience Research InstNoninvasive surgery method and apparatus
US4182311 *22 Apr 19778 Jan 1980Varian Associates, Inc.Method and system for cardiac computed tomography
US4254778 *22 May 197910 Mar 1981Emi LimitedImaging systems
US4315514 *8 May 198016 Feb 1982William DrewesMethod and apparatus for selective cell destruction
US4396903 *29 May 19812 Aug 1983Westinghouse Electric Corp.Electro-optical system for correlating and integrating image data from frame-to-frame
US4530358 *3 Mar 198323 Jul 1985Dornier System GmbhApparatus for comminuting concretions in bodies of living beings
US4638798 *10 Sep 198027 Jan 1987Shelden C HunterStereotactic method and apparatus for locating and treating or removing lesions
US4658828 *30 Apr 198521 Apr 1987Jacques DoryApparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment
US4669483 *19 Jul 19852 Jun 1987Dornier System GmbhLithotripsy system having locating and orienting apparatus
US4757820 *12 Mar 198619 Jul 1988Kabushiki Kaisha ToshibaUltrasound therapy system
US4763652 *16 Apr 198616 Aug 1988Northgate Research, Inc.Aiming system for kidney stone disintegrator
US4771787 *11 Dec 198620 Sep 1988Richard Wolf GmbhUltrasonic scanner and shock wave generator
US4791934 *7 Aug 198620 Dec 1988Picker International, Inc.Computer tomography assisted stereotactic surgery system and method
US4793355 *17 Apr 198727 Dec 1988Biomagnetic Technologies, Inc.Apparatus for process for making biomagnetic measurements
DE3617032A1 *21 May 19868 Jan 1987Elscint LtdUltrasonic apparatus for locating stone formations
DE3721187A1 *26 Jun 198721 Jan 1988Toshiba Kawasaki KkUltraschall-lithotripsievorrichtung
Non-Patent Citations
Reference
1Fry, F. J. "Precision High Intensity Focusing Ultrasonic Machines for Surgery", Am. Jour. of Phys. Med., vol. 37, No. 3 Jun. 1958.
2 *Fry, F. J. Precision High Intensity Focusing Ultrasonic Machines for Surgery , Am. Jour. of Phys. Med., vol. 37, No. 3 Jun. 1958.
3Fry, W. J., Fry, F. J. "Fundamental Neurological Research and Human Neurosurgery Using Intense Ultrasound" IRE Trans. on Med. Elec., vol. ME-7, Jul. 1960, U.S.A.
4 *Fry, W. J., Fry, F. J. Fundamental Neurological Research and Human Neurosurgery Using Intense Ultrasound IRE Trans. on Med. Elec., vol. ME 7, Jul. 1960, U.S.A.
5Myers, R., Fry, F. J., Fry, W. J., Eggleton, R. C., Schultz, Donald F. "Determination of Topologic Human Brain Representations . . . ", Neurology, Minneapolis, Mar. 1960, vol. 10, No. 3, 1960.
6 *Myers, R., Fry, F. J., Fry, W. J., Eggleton, R. C., Schultz, Donald F. Determination of Topologic Human Brain Representations . . . , Neurology, Minneapolis, Mar. 1960, vol. 10, No. 3, 1960.
7Slater, J. M., Chu, W. T., Chrispens, J. E., Neilsen, I. R. "An Integrated Ultrasonic-Computer Dosimetry System for Radiation Therapy", Proceedings of the Symposium on Advances in Biomedical Dosimetry, Vienna Austria (10-14 Mar. 1975).
8 *Slater, J. M., Chu, W. T., Chrispens, J. E., Neilsen, I. R. An Integrated Ultrasonic Computer Dosimetry System for Radiation Therapy , Proceedings of the Symposium on Advances in Biomedical Dosimetry, Vienna Austria (10 14 Mar. 1975).
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US5107839 *4 May 199028 Apr 1992Pavel V. HoudekComputer controlled stereotaxic radiotherapy system and method
US5437278 *10 Jan 19921 Aug 1995Wilk; Peter J.Medical diagnosis system and method
US5665141 *11 Jan 19969 Sep 1997Arjo Hospital Equipment AbUltrasonic treatment process
US5676692 *28 Mar 199614 Oct 1997Indianapolis Center For Advanced Research, Inc.Focussed ultrasound tissue treatment method
US5787886 *10 Apr 19954 Aug 1998Compass International IncorporatedMagnetic field digitizer for stereotatic surgery
US5842990 *21 Aug 19971 Dec 1998Northrop Grumman CorporationStereotactic ultrasonic diagnostic process
US614639025 Feb 200014 Nov 2000Sofamor Danek Holdings, Inc.Apparatus and method for photogrammetric surgical localization
US616518115 Oct 199826 Dec 2000Sofamor Danek Holdings, Inc.Apparatus and method for photogrammetric surgical localization
US634123111 Oct 200022 Jan 2002Visualization Technology, Inc.Position tracking and imaging system for use in medical applications
US636153121 Jan 200026 Mar 2002Medtronic Xomed, Inc.Focused ultrasound ablation devices having malleable handle shafts and methods of using the same
US640972031 Jul 200025 Jun 2002Medtronic Xomed, Inc.Methods of tongue reduction using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US641325419 Jan 20002 Jul 2002Medtronic Xomed, Inc.Method of tongue reduction by thermal ablation using high intensity focused ultrasound
US644594314 Dec 19983 Sep 2002Visualization Technology, Inc.Position tracking and imaging system for use in medical applications
US649170229 May 200110 Dec 2002Sofamor Danek Holdings, Inc.Apparatus and method for photogrammetric surgical localization
US649713415 Mar 200024 Dec 2002Image Guided Technologies, Inc.Calibration of an instrument
US649948828 Oct 199931 Dec 2002Winchester Development AssociatesSurgical sensor
US6505063 *13 Dec 20007 Jan 2003Koninklijke Philips Electronics N.V.Diagnostic imaging system with ultrasound probe
US659593431 Jul 200022 Jul 2003Medtronic Xomed, Inc.Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US661114122 Dec 199926 Aug 2003Howmedica Leibinger IncHybrid 3-D probe tracked by multiple sensors
US668564030 Mar 19993 Feb 2004Focus Surgery, Inc.Ablation system
US668753122 Aug 20003 Feb 2004Ge Medical Systems Global Technology Company, LlcPosition tracking and imaging system for use in medical applications
US6689087 *28 Mar 200210 Feb 2004Cybersonics, Inc.Floating probe for ultrasonic transducers
US669245019 Jan 200017 Feb 2004Medtronic Xomed, Inc.Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US669416722 Aug 200017 Feb 2004Ge Medical Systems Global Technology Company, LlcSystem for monitoring a position of a medical instrument with respect to a patient's head
US673865622 Aug 200018 May 2004Ge Medical Systems Global Technology Company, LlcAutomatic registration system for use with position tracking an imaging system for use in medical applications
US689209019 Aug 200210 May 2005Surgical Navigation Technologies, Inc.Method and apparatus for virtual endoscopy
US691892228 Jan 200319 Jul 2005Amir OronIschemia laser treatment
US692034721 Jun 200219 Jul 2005Surgical Navigation Technologies, Inc.Trajectory storage apparatus and method for surgical navigation systems
US69345753 Sep 200223 Aug 2005Ge Medical Systems Global Technology Company, LlcPosition tracking and imaging system for use in medical applications
US693604618 Jun 200330 Aug 2005Medtronic, Inc.Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US694778628 Feb 200220 Sep 2005Surgical Navigation Technologies, Inc.Method and apparatus for perspective inversion
US696822419 Sep 200322 Nov 2005Surgical Navigation Technologies, Inc.Method of detecting organ matter shift in a patient
US70076997 Nov 20027 Mar 2006Surgical Navigation Technologies, Inc.Surgical sensor
US708540014 Jun 20001 Aug 2006Surgical Navigation Technologies, Inc.System and method for image based sensor calibration
US713067629 Aug 200231 Oct 2006Sofamor Danek Holdings, Inc.Fluoroscopic image guided orthopaedic surgery system with intraoperative registration
US717420217 Dec 20026 Feb 2007British TelecommunicationsMedical navigation apparatus
US721104412 Dec 20031 May 2007Ethicon Endo-Surgery, Inc.Method for mapping temperature rise using pulse-echo ultrasound
US722946926 Apr 200312 Jun 2007Quantumcor, Inc.Methods for treating and repairing mitral valve annulus
US73035789 Oct 20034 Dec 2007Photothera, Inc.Device and method for providing phototherapy to the brain
US730934819 Jan 200518 Dec 2007Photothera, Inc.Method for treatment of depression
US73169228 Jan 20038 Jan 2008Photothera Inc.Method for preserving organs for transplant
US734455523 Dec 200418 Mar 2008The United States Of America As Represented By The Department Of Health And Human ServicesLight promotes regeneration and functional recovery after spinal cord injury
US73876124 Dec 200317 Jun 2008Cybersonics, Inc.Floating probe for ultrasonic transducers
US739332516 Sep 20041 Jul 2008Guided Therapy Systems, L.L.C.Method and system for ultrasound treatment with a multi-directional transducer
US745235722 Oct 200418 Nov 2008Ethicon Endo-Surgery, Inc.System and method for planning treatment of tissue
US747322422 May 20026 Jan 2009Ethicon Endo-Surgery, Inc.Deployable ultrasound medical transducers
US747325021 May 20046 Jan 2009Ethicon Endo-Surgery, Inc.Ultrasound medical system and method
US74911717 Oct 200517 Feb 2009Guided Therapy Systems, L.L.C.Method and system for treating acne and sebaceous glands
US749446716 Apr 200424 Feb 2009Ethicon Endo-Surgery, Inc.Medical system having multiple ultrasound transducers or an ultrasound transducer and an RF electrode
US753095824 Sep 200412 May 2009Guided Therapy Systems, Inc.Method and system for combined ultrasound treatment
US753425526 Jan 200419 May 2009Photothera, IncLow level light therapy for enhancement of neurologic function
US755990521 Sep 200614 Jul 2009Focus Surgery, Inc.HIFU probe for treating tissue with in-line degassing of fluid
US760196628 Jun 200713 Oct 2009Spectrum Dynamics LlcImaging techniques for reducing blind spots
US761501520 Jun 200310 Nov 2009Medtronic, Inc.Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US7652259 *4 Nov 200326 Jan 2010Spectrum Dynamics LlcApparatus and methods for imaging and attenuation correction
US765730021 Mar 20022 Feb 2010Medtronic Navigation, Inc.Registration of human anatomy integrated for electromagnetic localization
US766062330 Jan 20039 Feb 2010Medtronic Navigation, Inc.Six degree of freedom alignment display for medical procedures
US76621142 Mar 200516 Feb 2010Focus Surgery, Inc.Ultrasound phased arrays
US76955047 Jan 200813 Apr 2010The United States Of America As Represented By The Department Of Health And Human ServicesMethod for regeneration and functional recovery after spinal cord injury using phototherapy
US769797214 Jul 200313 Apr 2010Medtronic Navigation, Inc.Navigation system for cardiac therapies
US77251622 Oct 200325 May 2010Howmedica Leibinger Inc.Surgery system
US775186515 Sep 20046 Jul 2010Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US77585246 Oct 200520 Jul 2010Guided Therapy Systems, L.L.C.Method and system for ultra-high frequency ultrasound treatment
US776303513 Sep 200427 Jul 2010Medtronic Navigation, Inc.Image guided spinal surgery guide, system and method for use thereof
US779703223 Sep 200214 Sep 2010Medtronic Navigation, Inc.Method and system for navigating a catheter probe in the presence of field-influencing objects
US780683914 Jun 20045 Oct 2010Ethicon Endo-Surgery, Inc.System and method for ultrasound therapy using grating lobes
US780689222 May 20025 Oct 2010Ethicon Endo-Surgery, Inc.Tissue-retaining system for ultrasound medical treatment
US781557012 Jun 200719 Oct 2010Ultrashape Ltd.Non-invasive ultrasonic body contouring
US781804425 Mar 200819 Oct 2010Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US782434816 Sep 20042 Nov 2010Guided Therapy Systems, L.L.C.System and method for variable depth ultrasound treatment
US78268894 Dec 20002 Nov 2010Spectrum Dynamics LlcRadioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US78310825 Jun 20069 Nov 2010Medtronic Navigation, Inc.System and method for image based sensor calibration
US783322122 Oct 200416 Nov 2010Ethicon Endo-Surgery, Inc.System and method for treatment of tissue using the tissue as a fiducial
US783577816 Oct 200316 Nov 2010Medtronic Navigation, Inc.Method and apparatus for surgical navigation of a multiple piece construct for implantation
US783578421 Sep 200516 Nov 2010Medtronic Navigation, Inc.Method and apparatus for positioning a reference frame
US784025330 Sep 200523 Nov 2010Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US784609624 Nov 20037 Dec 2010Ethicon Endo-Surgery, Inc.Method for monitoring of medical treatment using pulse-echo ultrasound
US784803518 Sep 20087 Dec 2010Photothera, Inc.Single-use lens assembly
US785330513 May 200514 Dec 2010Medtronic Navigation, Inc.Trajectory storage apparatus and method for surgical navigation systems
US787223515 Jan 200618 Jan 2011Spectrum Dynamics LlcMulti-dimensional image reconstruction and analysis for expert-system diagnosis
US787502320 Feb 200825 Jan 2011Ultrashape Ltd.Non-invasive ultrasonic body contouring
US788177016 Mar 20041 Feb 2011Medtronic Navigation, Inc.Multiple cannula image guided tool for image guided procedures
US788346818 May 20048 Feb 2011Ethicon Endo-Surgery, Inc.Medical system having an ultrasound source and an acoustic coupling medium
US792532817 Dec 200712 Apr 2011Medtronic Navigation, Inc.Method and apparatus for performing stereotactic surgery
US795109520 May 200431 May 2011Ethicon Endo-Surgery, Inc.Ultrasound medical system
US795347127 Jul 200931 May 2011Medtronic Navigation, Inc.Method and apparatus for implantation between two vertebral bodies
US796885122 Mar 201028 Jun 2011Spectrum Dynamics LlcDynamic spect camera
US797134125 Mar 20085 Jul 2011Medtronic Navigation, Inc.Method of forming an electromagnetic sensing coil in a medical instrument for a surgical navigation system
US797467728 May 20095 Jul 2011Medtronic Navigation, Inc.Method and apparatus for preplanning a surgical procedure
US799606419 Oct 20099 Aug 2011Medtronic Navigation, Inc.System and method for placing and determining an appropriately sized surgical implant
US799806219 Jun 200716 Aug 2011Superdimension, Ltd.Endoscope structures and techniques for navigating to a target in branched structure
US800077331 Oct 200716 Aug 2011Spectrum Dynamics LlcRadioimaging
US80074488 Oct 200430 Aug 2011Stryker Leibinger Gmbh & Co. Kg.System and method for performing arthroplasty of a joint and tracking a plumb line plane
US80256874 May 200927 Sep 2011Photothera, Inc.Low level light therapy for enhancement of neurologic function
US803673110 Jul 200311 Oct 2011Spectrum Dynamics LlcIngestible pill for diagnosing a gastrointestinal tract
US80386313 Mar 200918 Oct 2011Sanghvi Narendra TLaparoscopic HIFU probe
US804605224 Mar 201025 Oct 2011Medtronic Navigation, Inc.Navigation system for cardiac therapies
US805532922 Jan 20028 Nov 2011Spectrum Dynamics LlcIngestible device for radioimaging of the gastrointestinal tract
US80573899 Jun 200815 Nov 2011Guided Therapy Systems, LlcMethod and system for ultrasound treatment with a multi-directional transducer
US805740711 Oct 200515 Nov 2011Medtronic Navigation, Inc.Surgical sensor
US80601855 Oct 200915 Nov 2011Medtronic Navigation, Inc.Navigation system for cardiac therapies
US80666416 Oct 200529 Nov 2011Guided Therapy Systems, L.L.C.Method and system for treating photoaged tissue
US807466231 Jul 200613 Dec 2011Medtronic Navigation, Inc.Surgical communication and power system
US80948941 Dec 200610 Jan 2012Spectrum Dynamics LlcRadioactive-emission-measurement optimization to specific body structures
US810533921 Jul 201031 Jan 2012Sofamor Danek Holdings, Inc.Image guided spinal surgery guide system and method for use thereof
US811188619 Jul 20067 Feb 2012Spectrum Dynamics LlcReconstruction stabilizer and active vision
US811229221 Apr 20067 Feb 2012Medtronic Navigation, Inc.Method and apparatus for optimizing a therapy
US81331806 Oct 200513 Mar 2012Guided Therapy Systems, L.L.C.Method and system for treating cellulite
US81495262 Nov 20103 Apr 2012Photothera, Inc.Single use lens assembly
US816565826 Sep 200824 Apr 2012Medtronic, Inc.Method and apparatus for positioning a guide relative to a base
US816633224 Jul 200924 Apr 2012Ardent Sound, Inc.Treatment system for enhancing safety of computer peripheral for use with medical devices by isolating host AC power
US816792120 Jun 20111 May 2012Jackson StreeterLow level light therapy for enhancement of neurologic function
US817568116 Dec 20088 May 2012Medtronic Navigation Inc.Combination of electromagnetic and electropotential localization
US820031422 Jan 200712 Jun 2012British Telecommunications Public Limited CompanySurgical navigation
US820450028 Dec 200619 Jun 2012Starhome GmbhOptimal voicemail deposit for roaming cellular telephony
US823590211 Sep 20077 Aug 2012Focus Surgery, Inc.System and method for tissue change monitoring during HIFU treatment
US823590911 May 20057 Aug 2012Guided Therapy Systems, L.L.C.Method and system for controlled scanning, imaging and/or therapy
US823900111 Jul 20057 Aug 2012Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US82710691 Jul 201018 Sep 2012Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US82801241 Jun 20052 Oct 2012Spectrum Dynamics LlcMethods of view selection for radioactive emission measurements
US828255411 Apr 20129 Oct 2012Guided Therapy Systems, LlcMethods for treatment of sweat glands
US829057010 Sep 200416 Oct 2012Stryker Leibinger Gmbh & Co., KgSystem for ad hoc tracking of an object
US829057213 Sep 201016 Oct 2012Medtronic Navigation, Inc.Method and system for navigating a catheter probe in the presence of field-influencing objects
US830878423 Aug 200713 Nov 2012Jackson StreeterLow level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US83206538 Nov 201027 Nov 2012Medtronic Navigation, Inc.System and method for image based sensor calibration
US832879815 May 200711 Dec 2012Quantumcor, IncMethod for treating and repairing mitral valve annulus
US832885725 Feb 201011 Dec 2012The United States Of America As Represented By The Department Of Health And Human ServicesMethod for treating a patient having a spinal cord injury using phototherapy
US83337004 Sep 201218 Dec 2012Guided Therapy Systems, L.L.C.Methods for treatment of hyperhidrosis
US83387883 Jun 201025 Dec 2012Spectrum Dynamics LlcMethod and system of optimized volumetric imaging
US83597301 Jul 201129 Jan 2013Medtronic Navigation, Inc.Method of forming an electromagnetic sensing coil in a medical instrument
US836662211 Apr 20125 Feb 2013Guided Therapy Systems, LlcTreatment of sub-dermal regions for cosmetic effects
US83827656 Aug 200826 Feb 2013Stryker Leibinger Gmbh & Co. Kg.Method of and system for planning a surgery
US840161623 Sep 201119 Mar 2013Medtronic Navigation, Inc.Navigation system for cardiac therapies
US840909724 Mar 20112 Apr 2013Ardent Sound, IncVisual imaging system for ultrasonic probe
US842312531 Oct 200716 Apr 2013Spectrum Dynamics LlcRadioimaging
US844456212 Jun 201221 May 2013Guided Therapy Systems, LlcSystem and method for treating muscle, tendon, ligament and cartilage tissue
US844585131 Oct 200721 May 2013Spectrum Dynamics LlcRadioimaging
US84520682 Nov 201128 May 2013Covidien LpHybrid registration method
US845454017 Dec 20104 Jun 2013Yoram EshelNon-invasive ultrasonic body contouring
US84601933 Jun 201011 Jun 2013Guided Therapy Systems LlcSystem and method for ultra-high frequency ultrasound treatment
US84675892 Nov 201118 Jun 2013Covidien LpHybrid registration method
US846785115 Nov 201018 Jun 2013Medtronic Navigation, Inc.Method and apparatus for positioning a reference frame
US846785314 Nov 201118 Jun 2013Medtronic Navigation, Inc.Navigation system for cardiac therapies
US847302621 Nov 200625 Jun 2013Ge Medical Systems Global Technology CompanySystem for monitoring a position of a medical instrument with respect to a patient's body
US84730322 Jun 200925 Jun 2013Superdimension, Ltd.Feature-based registration method
US84805854 May 20079 Jul 2013Guided Therapy Systems, LlcImaging, therapy and temperature monitoring ultrasonic system and method
US848917621 Aug 200016 Jul 2013Spectrum Dynamics LlcRadioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US849272524 Dec 201223 Jul 2013Biosensors International Group Ltd.Method and system of optimized volumetric imaging
US849461327 Jul 201023 Jul 2013Medtronic, Inc.Combination localization system
US849461427 Jul 201023 Jul 2013Regents Of The University Of MinnesotaCombination localization system
US850648616 Nov 201213 Aug 2013Guided Therapy Systems, LlcUltrasound treatment of sub-dermal tissue for cosmetic effects
US852125329 Oct 200727 Aug 2013Spectrum Dynamics LlcProstate imaging
US85237754 Sep 20123 Sep 2013Guided Therapy Systems, LlcEnergy based hyperhidrosis treatment
US85352288 Feb 200817 Sep 2013Guided Therapy Systems, LlcMethod and system for noninvasive face lifts and deep tissue tightening
US85485651 Feb 20101 Oct 2013Medtronic Navigation, Inc.Registration of human anatomy integrated for electromagnetic localization
US85497321 Jul 20118 Oct 2013Medtronic Navigation, Inc.Method of forming an electromagnetic sensing coil in a medical instrument
US856586010 Jul 200322 Oct 2013Biosensors International Group, Ltd.Radioactive emission detector equipped with a position tracking system
US857188117 May 200729 Oct 2013Spectrum Dynamics, LlcRadiopharmaceutical dispensing, administration, and imaging
US85869329 May 200719 Nov 2013Spectrum Dynamics LlcSystem and method for radioactive emission measurement
US860634931 Oct 200710 Dec 2013Biosensors International Group, Ltd.Radioimaging using low dose isotope
US861007513 Nov 200717 Dec 2013Biosensors International Group Ltd.Radioimaging applications of and novel formulations of teboroxime
US86119846 Apr 201017 Dec 2013Covidien LpLocatable catheter
US861540531 Oct 200724 Dec 2013Biosensors International Group, Ltd.Imaging system customization using data from radiopharmaceutical-associated data carrier
US861717329 Jan 201331 Dec 2013Stryker Leibinger Gmbh & Co. KgSystem for assessing a fit of a femoral implant
US861717429 Jan 201331 Dec 2013Stryker Leibinger Gmbh & Co. KgMethod of virtually planning a size and position of a prosthetic implant
US86200468 Jan 201231 Dec 2013Biosensors International Group, Ltd.Radioactive-emission-measurement optimization to specific body structures
US862067931 Oct 200731 Dec 2013Biosensors International Group, Ltd.Radiopharmaceutical dispensing, administration, and imaging
US863489713 Dec 201021 Jan 2014Medtronic Navigation, Inc.Trajectory storage apparatus and method for surgical navigation systems
US86366657 Mar 201328 Jan 2014Guided Therapy Systems, LlcMethod and system for ultrasound treatment of fat
US864162212 Sep 20114 Feb 2014Guided Therapy Systems, LlcMethod and system for treating photoaged tissue
US864490729 Apr 20104 Feb 2014Medtronic Navigaton, Inc.Method and apparatus for surgical navigation
US864491019 Jul 20064 Feb 2014Biosensors International Group, Ltd.Imaging protocols
US86606358 Mar 200725 Feb 2014Medtronic, Inc.Method and apparatus for optimizing a computer assisted surgical procedure
US86630882 Dec 20094 Mar 2014Covidien LpSystem of accessories for use with bronchoscopes
US866311223 Dec 20094 Mar 2014Guided Therapy Systems, LlcMethods and systems for fat reduction and/or cellulite treatment
US867284823 Jan 201218 Mar 2014Guided Therapy Systems, LlcMethod and system for treating cellulite
US867629223 Jan 200718 Mar 2014Biosensors International Group, Ltd.Multi-dimensional image reconstruction
US869077821 Jun 20138 Apr 2014Guided Therapy Systems, LlcEnergy-based tissue tightening
US869077921 Jun 20138 Apr 2014Guided Therapy Systems, LlcNoninvasive aesthetic treatment for tightening tissue
US869078021 Jun 20138 Apr 2014Guided Therapy Systems, LlcNoninvasive tissue tightening for cosmetic effects
US86965489 Jun 201115 Apr 2014Covidien LpEndoscope structures and techniques for navigating to a target in branched structure
US869668512 Mar 201015 Apr 2014Covidien LpEndoscope structures and techniques for navigating to a target in branched structure
US870618515 Nov 201022 Apr 2014Medtronic Navigation, Inc.Method and apparatus for surgical navigation of a multiple piece construct for implantation
US870893512 Jul 201029 Apr 2014Guided Therapy Systems, LlcSystem and method for variable depth ultrasound treatment
US871518624 Nov 20106 May 2014Guided Therapy Systems, LlcMethods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US87316417 May 201220 May 2014Medtronic Navigation, Inc.Combination of electromagnetic and electropotential localization
US874882610 Jun 201310 Jun 2014Biosensor International Group, Ltd.Radioimaging methods using teboroxime and thallium
US874882722 Jul 201310 Jun 2014Biosensors International Group, Ltd.Method and system of optimized volumetric imaging
US87646877 May 20081 Jul 2014Guided Therapy Systems, LlcMethods and systems for coupling and focusing acoustic energy using a coupler member
US876472514 Nov 20081 Jul 2014Covidien LpDirectional anchoring mechanism, method and applications thereof
US876843725 Oct 20061 Jul 2014Sofamor Danek Holdings, Inc.Fluoroscopic image guided surgery system with intraoperative registration
US88377939 Jan 201216 Sep 2014Biosensors International Group, Ltd.Reconstruction stabilizer and active vision
US883819914 Feb 200516 Sep 2014Medtronic Navigation, Inc.Method and apparatus for virtual digital subtraction angiography
US884565516 Aug 201030 Sep 2014Medtronic Navigation, Inc.Instrument guide system
US88574388 Nov 201114 Oct 2014Ulthera, Inc.Devices and methods for acoustic shielding
US885847110 Jul 201214 Oct 2014Guided Therapy Systems, LlcMethods and systems for ultrasound treatment
US886895823 Apr 201221 Oct 2014Ardent Sound, IncMethod and system for enhancing computer peripheral safety
US889497411 May 200725 Nov 2014Spectrum Dynamics LlcRadiopharmaceuticals for diagnosis and therapy
US890592019 Sep 20089 Dec 2014Covidien LpBronchoscope adapter and method
US890932511 Jul 20019 Dec 2014Biosensors International Group, Ltd.Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US891585315 Mar 201323 Dec 2014Guided Therapy Systems, LlcMethods for face and neck lifts
US891585427 Jan 201423 Dec 2014Guided Therapy Systems, LlcMethod for fat and cellulite reduction
US89158706 Oct 200923 Dec 2014Guided Therapy Systems, LlcMethod and system for treating stretch marks
US892032427 Feb 201430 Dec 2014Guided Therapy Systems, LlcEnergy based fat reduction
US893220710 Jul 200913 Jan 2015Covidien LpIntegrated multi-functional endoscopic tool
US893222425 Jul 201313 Jan 2015Guided Therapy Systems, LlcEnergy based hyperhidrosis treatment
US900514418 Dec 201214 Apr 2015Michael H. SlaytonTissue-retaining systems for ultrasound medical treatment
US90113367 May 200821 Apr 2015Guided Therapy Systems, LlcMethod and system for combined energy therapy profile
US901133711 Jul 201221 Apr 2015Guided Therapy Systems, LlcSystems and methods for monitoring and controlling ultrasound power output and stability
US90396176 May 201426 May 2015Guided Therapy Systems, LlcMethods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US903961931 Jan 201426 May 2015Guided Therapy Systems, L.L.C.Methods for treating skin laxity
US904001619 Jul 200726 May 2015Biosensors International Group, Ltd.Diagnostic kit and methods for radioimaging myocardial perfusion
US90558811 May 200516 Jun 2015Super Dimension Ltd.System and method for image-based alignment of an endoscope
US908926114 Sep 200428 Jul 2015Covidien LpSystem of accessories for use with bronchoscopes
US909569523 Oct 20074 Aug 2015Focus Surgery, Inc.Method and apparatus for treatment of tissue
US909569713 Aug 20134 Aug 2015Guided Therapy Systems, LlcMethods for preheating tissue for cosmetic treatment of the face and body
US911381317 Dec 201325 Aug 2015Covidien LpLocatable catheter
US911424710 Nov 201125 Aug 2015Guided Therapy Systems, LlcMethod and system for ultrasound treatment with a multi-directional transducer
US911725820 May 201325 Aug 2015Covidien LpFeature-based registration method
US913228717 Aug 201015 Sep 2015T. Douglas MastSystem and method for ultrasound treatment using grating lobes
US91496582 Aug 20116 Oct 2015Guided Therapy Systems, LlcSystems and methods for ultrasound treatment
US916810218 Jan 200627 Oct 2015Medtronic Navigation, Inc.Method and apparatus for providing a container to a sterile environment
US92162767 May 200822 Dec 2015Guided Therapy Systems, LlcMethods and systems for modulating medicants using acoustic energy
US92416834 Oct 200626 Jan 2016Ardent Sound Inc.Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
US926159629 Oct 201016 Feb 2016T. Douglas MastMethod for monitoring of medical treatment using pulse-echo ultrasound
US926366315 Apr 201316 Feb 2016Ardent Sound, Inc.Method of making thick film transducer arrays
US92718032 May 20131 Mar 2016Covidien LpHybrid registration method
US92721628 Jul 20131 Mar 2016Guided Therapy Systems, LlcImaging, therapy, and temperature monitoring ultrasonic method
US927545120 Dec 20071 Mar 2016Biosensors International Group, Ltd.Method, a system, and an apparatus for using and processing multidimensional data
US928340921 Nov 201415 Mar 2016Guided Therapy Systems, LlcEnergy based fat reduction
US928341021 Nov 201415 Mar 2016Guided Therapy Systems, L.L.C.System and method for fat and cellulite reduction
US931674318 Nov 201319 Apr 2016Biosensors International Group, Ltd.System and method for radioactive emission measurement
US932053712 Aug 201326 Apr 2016Guided Therapy Systems, LlcMethods for noninvasive skin tightening
US93459106 Apr 201524 May 2016Guided Therapy Systems LlcMethods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US937033326 Dec 201321 Jun 2016Biosensors International Group, Ltd.Radioactive-emission-measurement optimization to specific body structures
US942102916 Dec 201423 Aug 2016Guided Therapy Systems, LlcEnergy based hyperhidrosis treatment
US942760021 Apr 201530 Aug 2016Guided Therapy Systems, L.L.C.Systems for treating skin laxity
US942760126 Nov 201430 Aug 2016Guided Therapy Systems, LlcMethods for face and neck lifts
US944009626 Nov 201413 Sep 2016Guided Therapy Systems, LlcMethod and system for treating stretch marks
US945230210 Jul 201227 Sep 2016Guided Therapy Systems, LlcSystems and methods for accelerating healing of implanted material and/or native tissue
US945720212 Sep 20144 Oct 2016SonaCare Medical, LLCMethod of diagnosis and treatment of tumors using high intensity focused ultrasound
US947080128 Dec 200618 Oct 2016Spectrum Dynamics LlcGating with anatomically varying durations
US950444611 Jul 201229 Nov 2016Guided Therapy Systems, LlcSystems and methods for coupling an ultrasound source to tissue
US95045303 Feb 201429 Nov 2016Medtronic Navigation, Inc.Method and apparatus for surgical navigation
US951080225 Mar 20146 Dec 2016Guided Therapy Systems, LlcReflective ultrasound technology for dermatological treatments
US952229011 Feb 201620 Dec 2016Guided Therapy Systems, LlcSystem and method for fat and cellulite reduction
US953317511 Feb 20163 Jan 2017Guided Therapy Systems, LlcEnergy based fat reduction
US956645423 Apr 200714 Feb 2017Guided Therapy Systems, LlcMethod and sysem for non-ablative acne treatment and prevention
US95751402 Apr 200921 Feb 2017Covidien LpMagnetic interference detection system and method
US959715424 Feb 201421 Mar 2017Medtronic, Inc.Method and apparatus for optimizing a computer assisted surgical procedure
US964251411 Apr 20149 May 2017Covidien LpEndoscope structures and techniques for navigating to a target in a branched structure
US965937424 Jul 201523 May 2017Covidien LpFeature-based registration method
US96686398 Jun 20126 Jun 2017Covidien LpBronchoscope adapter and method
US967542422 Jul 200913 Jun 2017Surgical Navigation Technologies, Inc.Method for calibrating a navigation system
US969421126 Aug 20164 Jul 2017Guided Therapy Systems, L.L.C.Systems for treating skin laxity
US96942129 Sep 20164 Jul 2017Guided Therapy Systems, LlcMethod and system for ultrasound treatment of skin
US970034011 Jun 201311 Jul 2017Guided Therapy Systems, LlcSystem and method for ultra-high frequency ultrasound treatment
US97074129 Dec 201618 Jul 2017Guided Therapy Systems, LlcSystem and method for fat and cellulite reduction
US971373115 Dec 201625 Jul 2017Guided Therapy Systems, LlcEnergy based fat reduction
US975708729 Jun 200912 Sep 2017Medtronic Navigation, Inc.Method and apparatus for perspective inversion
US979580316 Sep 201124 Oct 2017Pthera LLCLow level light therapy for enhancement of neurologic function
US98020638 Nov 201631 Oct 2017Guided Therapy Systems, LlcReflective ultrasound technology for dermatological treatments
US20030109906 *1 Nov 200212 Jun 2003Jackson StreeterLow level light therapy for the treatment of stroke
US20030144712 *20 Dec 200231 Jul 2003Jackson Streeter, M.D.Methods for overcoming organ transplant rejection
US20030191396 *19 Sep 20019 Oct 2003Sanghvi Narendra TTissue treatment method and apparatus
US20030212351 *18 Jun 200313 Nov 2003Hissong James B.Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20030216797 *28 Jan 200320 Nov 2003Amir OronIschemia laser treatment
US20040014199 *8 Jan 200322 Jan 2004Jackson StreeterMethod for preserving organs for transplant
US20040059266 *22 Sep 200325 Mar 2004Fry Francis J.Ablation system
US20040082884 *4 Dec 200329 Apr 2004Dharmendra PalFloating probe for ultrasonic transducers
US20040132002 *17 Sep 20038 Jul 2004Jackson StreeterMethods for preserving blood
US20040138727 *9 Oct 200315 Jul 2004Taboada Luis DeDevice and method for providing phototheraphy to the brain
US20040153130 *29 May 20035 Aug 2004Amir OronMethods for treating muscular dystrophy
US20050055174 *4 Dec 200010 Mar 2005V Target Ltd.Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US20050187595 *19 Jan 200525 Aug 2005Jackson StreeterMethod for treatment of depression
US20050203595 *11 May 200515 Sep 2005Amir OronIschemia laser treatment
US20050240105 *14 Apr 200427 Oct 2005Mast T DMethod for reducing electronic artifacts in ultrasound imaging
US20050240127 *2 Mar 200527 Oct 2005Ralf SeipUltrasound phased arrays
US20050256406 *11 May 200517 Nov 2005Guided Therapy Systems, Inc.Method and system for controlled scanning, imaging and/or therapy
US20060036299 *23 Dec 200416 Feb 2006Anders Juanita JLight promotes regeneration and functional recovery after spinal cord injury
US20060058644 *10 Sep 200416 Mar 2006Harald HoppeSystem, device, and method for AD HOC tracking of an object
US20060058664 *16 Sep 200416 Mar 2006Guided Therapy Systems, Inc.System and method for variable depth ultrasound treatment
US20060058707 *16 Sep 200416 Mar 2006Guided Therapy Systems, Inc.Method and system for ultrasound treatment with a multi-directional transducer
US20060074313 *6 Oct 20056 Apr 2006Guided Therapy Systems, L.L.C.Method and system for treating cellulite
US20060074314 *6 Oct 20056 Apr 2006Guided Therapy Systems, L.L.C.Method and system for noninvasive mastopexy
US20060074355 *24 Sep 20046 Apr 2006Guided Therapy Systems, Inc.Method and system for combined ultrasound treatment
US20060079868 *7 Oct 200513 Apr 2006Guided Therapy Systems, L.L.C.Method and system for treatment of blood vessel disorders
US20060084891 *6 Oct 200520 Apr 2006Guided Therapy Systems, L.L.C.Method and system for ultra-high frequency ultrasound treatment
US20060095047 *8 Oct 20044 May 2006De La Barrera Jose Luis MSystem and method for performing arthroplasty of a joint and tracking a plumb line plane
US20060111744 *6 Oct 200525 May 2006Guided Therapy Systems, L.L.C.Method and system for treatment of sweat glands
US20060116671 *6 Oct 20051 Jun 2006Guided Therapy Systems, L.L.C.Method and system for controlled thermal injury of human superficial tissue
US20060122508 *6 Oct 20058 Jun 2006Guided Therapy Systems, L.L.C.Method and system for noninvasive face lifts and deep tissue tightening
US20060237652 *4 Nov 200326 Oct 2006Yoav KimchyApparatus and methods for imaging and attenuation correction
US20060241442 *6 Oct 200526 Oct 2006Guided Therapy Systems, L.L.C.Method and system for treating photoaged tissue
US20070010805 *8 Jul 200511 Jan 2007Fedewa Russell JMethod and apparatus for the treatment of tissue
US20070038096 *6 Jul 200515 Feb 2007Ralf SeipMethod of optimizing an ultrasound transducer
US20070208253 *4 May 20076 Sep 2007Guided Therapy Systems, Inc.Imaging, therapy and temperature monitoring ultrasonic system
US20070219448 *5 May 200520 Sep 2007Focus Surgery, Inc.Method and Apparatus for Selective Treatment of Tissue
US20080033291 *15 Jan 20067 Feb 2008Benny RoussoMulti-Dimensional Image Reconstruction and Analysis for Expert-System Diagnosis
US20080039724 *10 Aug 200614 Feb 2008Ralf SeipUltrasound transducer with improved imaging
US20080070229 *21 Nov 200720 Mar 2008Jackson StreeterMethod for preserving organs for transplantation
US20080071255 *19 Sep 200720 Mar 2008Barthe Peter GMethod and system for treating muscle, tendon, ligament and cartilage tissue
US20080077056 *21 Sep 200627 Mar 2008Shuhei KagosakiHIFU probe for treating tissue with in-line degassing of fluid
US20080091123 *23 Oct 200717 Apr 2008Focus Surgery, Inc.Method and apparatus for treatment of tissue
US20080091124 *23 Oct 200717 Apr 2008Focus Surgery, Inc.Method and apparatus for treatment of tissue
US20080221211 *1 Feb 200811 Sep 2008Jackson StreeterMethod of treatment of neurological injury or cancer by administration of dichloroacetate
US20080230705 *31 Oct 200725 Sep 2008Spectrum Dynamics LlcRadioimaging
US20080260228 *1 Jun 200523 Oct 2008Eli DichtermanMethods of View Selection for Radioactive Emission Measurements
US20080275342 *9 Jun 20086 Nov 2008Guided Therapy Systems, LlcMethod and system for ultrasound treatment with a multi-directional transducer
US20080281201 *12 Jun 200713 Nov 2008Yoram IshelNon-invasive ultrasonic body contouring
US20080281236 *7 Jan 200813 Nov 2008Yoram EshelDevices and methodologies useful in body aesthetics
US20080281237 *7 May 200813 Nov 2008Guded Therapy Systems, Llc.Methods and systems for coupling and focusing acoustic energy using a coupler member
US20080287836 *20 Feb 200820 Nov 2008Yoram EshelNon-invasive ultrasonic body contouring
US20080294073 *23 Apr 200727 Nov 2008Guided Therapy Systems, Inc.Method and sysem for non-ablative acne treatment and prevention
US20080319355 *20 Jun 200725 Dec 2008Henry NitaIschemic stroke therapy
US20090043556 *6 Aug 200812 Feb 2009Axelson Stuart LMethod of and system for planning a surgery
US20090254154 *13 Mar 20098 Oct 2009Luis De TaboadaMethod and apparatus for irradiating a surface with pulsed light
US20100011236 *24 Jul 200914 Jan 2010Guided Therapy Systems, L.L.C.Method and system for enhancing computer peripheral safety
US20100022921 *14 Sep 200928 Jan 2010Ralf SeipUltrasound phased arrays
US20100067128 *18 Sep 200818 Mar 2010Scott DelappSingle-use lens assembly
US20100092424 *21 Nov 200815 Apr 2010Sanghvi Narendra TMethod of diagnosis and treatment of tumors using high intensity focused ultrasound
US20100100014 *6 Feb 200522 Apr 2010Yoram EshelNon-Thermal Acoustic Tissue Modification
US20100152820 *25 Feb 201017 Jun 2010Anders Juanita JMethod for treating a patient having a spinal cord injury using phototherapy
US20100211136 *19 Feb 200919 Aug 2010Photothera, Inc.Apparatus and method for irradiating a surface with light
US20100241035 *3 Jun 201023 Sep 2010Guided Therapy Systems, L.L.C.System and method for ultra-high frequency ultrasound treatment
US20100256490 *18 Jun 20107 Oct 2010Makin Inder Raj SMedical system having an ultrasound source and an acoustic coupling medium
US20100280420 *12 Jul 20104 Nov 2010Guided Therapy Systems, LlcSystem and method for variable depth ultrasound treatment
US20100312150 *17 Aug 20109 Dec 2010Mast T DouglasSystem and method for medical treatment using ultrasound
US20110040184 *29 Oct 201017 Feb 2011Mast T DouglasMethod for monitoring of medical treatment using pulse-echo ultrasound
US20110060266 *29 Jul 201010 Mar 2011Photothera, Inc.Enhanced stem cell therapy and stem cell production through the administration of low level light energy
US20110087099 *17 Dec 201014 Apr 2011Ultrashape Ltd.Non-invasive ultrasonic body contouring
US20110144723 *16 Jun 201016 Jun 2011Photothera, Inc.Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US20110172530 *24 Mar 201114 Jul 2011Ardent Sound, Inc.Visual imaging system for ultrasonic probe
US20110178444 *24 Nov 201021 Jul 2011Slayton Michael HMethods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US20110201975 *21 Apr 201118 Aug 2011Makin Inder Raj SUltrasound medical system
US20110201976 *25 Apr 201118 Aug 2011Focus Surgery, Inc.Laparoscopic hifu probe
USRE4085224 Jan 200014 Jul 2009Medtronic Navigation, Inc.Method and system for navigating a catheter probe
USRE4106614 Jan 199929 Dec 2009Metronic Navigation, Inc.Method and system for navigating a catheter probe
USRE4219412 Jun 20061 Mar 2011Medtronic Navigation, Inc.Percutaneous registration apparatus and method for use in computer-assisted surgical navigation
USRE4222612 Jun 200615 Mar 2011Medtronic Navigation, Inc.Percutaneous registration apparatus and method for use in computer-assisted surgical navigation
USRE42803 *27 Jun 20074 Oct 2011Koninklijke Philips Electronics N.V.Ultrasonic method, system, and device for diagnosis of stroke
USRE4332831 Jan 200224 Apr 2012Medtronic Navigation, IncImage guided awl/tap/screwdriver
USRE4375013 Jul 200916 Oct 2012Medtronic Navigation, Inc.Method for navigating a catheter probe
USRE439525 Oct 199029 Jan 2013Medtronic Navigation, Inc.Interactive system for local intervention inside a non-homogeneous structure
USRE4430528 Feb 201118 Jun 2013Medtronic Navigation, Inc.Percutaneous registration apparatus and method for use in computer-assisted surgical navigation
USRE460498 Aug 20115 Jul 2016Koninklijke Philips Electronics N.V.Automatic external defibrillator for the diagnosis of stroke
USRE4640920 Apr 201523 May 2017Medtronic Navigation, Inc.Image guided awl/tap/screwdriver
USRE4642220 Apr 20156 Jun 2017Medtronic Navigation, Inc.Image guided awl/tap/screwdriver
CN102657918A *7 May 201212 Sep 2012中国科学院声学研究所Focusing method and device
EP0647457A1 *6 Oct 199412 Apr 1995Nomos CorporationMethod and apparatus for lesion position verification
EP0650075A2 *21 Oct 199426 Apr 1995Judith T. LewisAutomatic ultrasonic localization of targets implanted in a portion of the anatomy
EP0650075A3 *21 Oct 19947 Jan 1999Allen, George S.Automatic ultrasonic localization of targets implanted in a portion of the anatomy
WO1996032059A16 Nov 199517 Oct 1996Compass International IncorporatedMagnetic field digitizer for stereotactic surgery
Classifications
U.S. Classification601/3, 600/411, 600/427
International ClassificationA61B8/14, A61N7/00, A61F7/00, A61B19/00, A61B6/03
Cooperative ClassificationA61B90/10, A61B2090/378, A61N7/00, A61B2090/374, A61B8/0816
European ClassificationA61B19/20, A61N7/00
Legal Events
DateCodeEventDescription
29 Apr 1988ASAssignment
Owner name: LABSONICS, INC., 236 EAST WASHINGTON STREET, MOORE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:FRY, FRANCIS J.;SANGHVI, NARENDRA T.;REEL/FRAME:004860/0873
Effective date: 19880302
Owner name: LABSONICS, INC., A CORP., INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FRY, FRANCIS J.;SANGHVI, NARENDRA T.;REEL/FRAME:004860/0873
Effective date: 19880302
30 Jan 1989ASAssignment
Owner name: LABORATORY EQUIPMENT, CORP., A CORP. OF INDIANA, I
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:LABSONICS, INC.,;REEL/FRAME:005014/0391
Effective date: 19890103
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