|Publication number||US4440160 A|
|Application number||US 06/340,753|
|Publication date||3 Apr 1984|
|Filing date||19 Jan 1982|
|Priority date||19 Jan 1982|
|Also published as||CA1199977A1|
|Publication number||06340753, 340753, US 4440160 A, US 4440160A, US-A-4440160, US4440160 A, US4440160A|
|Inventors||Robert E. Fischell, Glen H. Fountain, Charles M. Blackburn|
|Original Assignee||The Johns Hopkins University|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (12), Non-Patent Citations (2), Referenced by (39), Classifications (6), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1. Field of the Invention
The invention relates to an apparatus for preventing self-injurious behavior in patients. More particularly, the invention teaches an improved apparatus for sensing self-injurious behavior and for transmitting a signal to a separate stimulation module which then supplies aversive electrical stimulation to the patient's skin.
2. Description of the Prior Art
The use of aversive stimulation to prevent certain types of behavior is known in the art. U.S. Pat. No. 3,998,209, issued to Gilbert Macvaugh on Dec. 21, 1976, teaches the application of electric shock pulses, generated by a charged capacitor circuit, for deconditioning snoring. U.S. Pat. No. 3,885,576, issued to Elliott Symmes, on May 27, 1975, teaches the use of electric shock as a means to deter smoking. In that patent a mercury switch is mounted on a wristband so that when the user moves his arm (e.g., to place a cigarette to his lips), the mercury switch closes and allows an electric current to flow to electrodes mounted on the user's wristband.
The use of aversive stimulation to inhibit self-injurious behavior was first described by Mooza Grant in U.S. Pat. No. 3,834,379, issued Sept. 10, 1974. Mooza Grant describes an apparatus which conditions psychotic self-destructive patients against self-injurious blows to the head. The apparatus contains a helmet which is mounted on the patient's head to absorb self-injurious blows. The helmet contains a metallic cylinder and a movable pin disposed centrally therein. When the patient strikes the helmet, the pin contacts with the cylinder and establishes an electrical contact which activates an electronic package (described as being disposed within a packet in patient's clothes.) An electrical pulse generated in the electronic package is sent to the electrodes contained in an arm band and provides an aversive electric shock to the patient's arm. The helmet, electronic package, and stimulation electrodes are all connected by electrical wires.
The prior art apparatus required bulky equipment and connecting cables which run between the sensing transducer, and the stimulation circuitry and electrodes. Observations of patients indicated that the connecting wires restricted the patient's activities. The invented apparatus contains a sensor module that is separate from the stimulation module and provides a wireless communication link between the sensor and stimulation modules.
The prior art aversive stimulation apparatus required a bulky helmet to support the sensing switch and also to protect the head. For the sensor module, the proposed apparatus of the present invention uses a miniature accelerometer and electrical circuitry which is contained in a single miniaturized hybrid circuit, all of which can be mounted on an elastic headband. The invented apparatus enables the patient to be conditioned against self-injurious behavior without requiring the patient to wear a bulky helmet which inhibits his or her activities, which can be uncomfortable when worn for extended time periods, and which causes the patient to have an abnormal appearance.
The inventors also observed that patients exhibiting such self-injurious behavior frequently injure body members other than the head. The present invention thus discloses a sensor module which can be attached to an elastic band and worn on any body member. Moreover, several of the invented sensor modules can be worn on different body members and can simultaneously communicate with a single stimulation module, and report an injurious blow to any of the sensed body members. Not only does the prior art not teach the use of multiple sensors but, the interconnection cables used in the prior art would entangle the patient in a web of wires if such sensing from multiple locations was attempted. Typical of other body members where sensing might be useful are elbows and knees.
The present invention uses a separate sensor and stimulation module, each made from a hybrid circuit containing (CMOS) integrated circuits. The sensor module detects a rapid acceleration or blow and transmits a signal to a remote stimulation module. The sensor module might be mounted on the body member that is being struck or on the body member that is doing the striking. In either case, it is to be understood that a body member is being struck. The transmission made by the sensor module can be by means of radio emissions (i.e., electromagnetic waves) or by a unique method of transmitting an electrical signal through the patient's body. The stimulation module detects and demodulates the transmitter signal and provides aversive stimulation in response to each detected self-injurious action. Aversive stimulation is provided by means of stimulation electrodes which are placed in contact with the patient's skin. In operation, each sensor module can detect self-injurious blows to a particular body member and communicate this information to the stimulation module which then provides an aversive electrical shock.
One novel feature of the invented apparatus is the use of a sensor module which is remote from and not connected by wires to the stimulation module.
The second novel feature of the invented apparatus is the use of a wireless communication link between the sensor and stimulation modules.
A third novel feature of the invented apparatus is the ability of the sensor module to transmit an electrical signal containing event information through the patient's body, and to have the transmitted signal be detected and be demodulated by the stimulation module.
A fourth novel feature of the invented apparatus is to mount the sensor module on an elastic band. As such, the sensor module can be worn as a headband (not a bulky helmet) to detect self-injurious blows to the head, and it can be worn on an arm or knee band to detect self-injurious behavior to the arm or leg respectively.
A fifth novel feature of the invented apparatus is that one or more sensor modules can simultaneously communicate with a single stimulation module. This feature allows the invented apparatus to be successfully used for patients who exhibit self-injurious behavior to more than one body member.
A sixth novel feature of the invented apparatus is the incorporation of a recording means in both the stimulation and sensor modules. This feature allows the invented apparatus to be a more useful diagnostic tool.
A seventh novel feature of the invented apparatus is an aversive stimulation system where the level of the electrical shock is adjustable to provide a minimum shock level that will accomplish the intended purpose.
FIG. 1 is an illustration of a person wearing the invented self-injurious behavior inhibiting system.
FIG. 2 is a block diagram of the sensor module.
FIG. 3 is a graph showing acceleration versus time for acceleration at the forehead caused by a mild blow to the head.
FIG. 4 is a table showing various accelerations a patient will experience during normal activities.
FIG. 5 is a block diagram of the stimulation module.
The proposed apparatus for inhibiting self-injurious behavior is illustrated in FIG. 1. The apparatus is generally composed of a sensor module subsystem 10 and a separate stimulation module subsystem 12. The sensor module subsystem 10 contains a sensor module 14 which is mounted on a headband 16 and detects blows to the patient's head. Although not illustrated in FIG. 1, the sensor module 14 could also be mounted on any other body member and detect blows to that body member (e.g., sensor modules could be mounted on an elastic elbow band, knee band, ankle band, wristband, etc.). For patients who exhibit injurious behavior to several different body members, it is within the scope of this invention to place sensor modules on several body members simultaneously, and to detect self-injurious blows to each of those body members. Furthermore, if the patient always uses his hand to strike a variety of body parts, then a sensor module mounted on his wrist could detect any body part being hit by his hand and this would cause an appropriate signal to be sent to the stimulation module. The stimulation module subsystem 12 is mounted on the patient's body at a position remote from the sensor module subsystem 10. The stimulation module subsystem 12 consists of a stimulation module 18 mounted on an elastic band 20. FIG. 2 shows the stimulation module subsystem 12 mounted on the patient's arm, although the stimulation module subsystem 12 could be mounted on other body members depending on its effectiveness for a particular patient.
Unlike the prior art, the invented apparatus contains no wires or cables connecting the sensor module 14 to the stimulation module 18. As will be described in greater detail, the sensor module 14 transmits a signal either through the body or by propagated radio waves to the stimulation module 18. The signal transmitted by the sensor module 14 carries event information which indicates when a blow has been sustained. The stimulation module 18 applies aversive stimulation to the patient in response to this event information. It is contemplated that several sensor modules mounted on different body members can transmit event information to a single stimulation module.
FIG. 2 is a block diagram of the sensor module 14. The sensor module would generally consist of a single hybrid circuit typically consisting of (CMOS) integrated circuit components chosen for their low voltage requirements, and particularly because of their low electrical power drain. The sensor module 14 contains a sensing means 22 for sensing a blow to a body member, and a transmitting means 24 for transmitting a signal to the stimulation module 18. The sensing means 14 further contains: a miniaturized two-axis or three-axis accelerometer 26; a small single cell battery (not shown), such as a Li So2 Cl battery; and, a "one-shot" circuit 28. The accelerometer 26 behaves as a switch and is closed momentarily when an accelerating impulse, above a set threshold level, is detected, and automatically resets after the acceleration impulse subsides. FIG. 3 contains a graph showing acceleration detected at the forehead of a person experiencing a mild blow to the head. A 2 g acceleration level is attained with a slight, non-damaging impulse to the head. A typical self-injurious blow might produce a 20 g acceleration to the head or other body member. A threshold level between 2 g's and 5 g's can be selected as values large enough to avoid aversive stimulation as a result of accelerations experienced in normal activity, and yet small enough to detect even a non-damaging impulse to the head. FIG. 4 contains a table showing some accelerations experienced in normal activities particularly in various types of transportation--(the threshold value is chosen so that acceleration experienced during transportation would not activate the invented apparatus.)
Although the use of an accelerometer switch is described herein, the sensor module could also use the actual blow to cause electrical contact between two surfaces or the blow might be detected by a change in capacitance caused by the proximity of two body members coming in contact.
Returning now to FIG. 2, a "one-shot" circuit 28, or its equivalent, is connected to the accelerometer 26 and will be activated when the accelerometer output exceeds a threshold level for a period longer than 10 milliseconds. (NOTE: A range of threshold values, other than those specified above, is contemplated by the inventors--any threshold value is acceptable which would be large enough to avoid stimulation during normal activity but sensitive enough to detect mild non-injurious blows.) The "one-shot" circuit 28 shall not accept another input from the accelerometer for the duration of a hold period (a hold period of 0.5 seconds is suggested). The "one-shot" circuit 28 sustains a level output during the hold period enabling the "one-shot" circuit 28 to "stretch" the electrical impulse received from the accelerometer 26 thus allowing the transmitting means 24 time to (1) be powered, (2) to be stabilized, and (3) to transmit a signal indicating the occurrence of the self-injurious blow.
The transmitting means 24 has two embodiments. In the first embodiment, the transmitter means 24, as shown in FIG. 2, contains a crystal oscillator clock 30 and an FSK transmitter 32, which generates FSK frequencies of 48 kHz (a logical "0") and 52 kHz (a logical "1"). The FSK transmitter 32 is of a design known in the communication art and will produce a [coded] signal at a 5-millisecond bit rate. The transmitter 32 is activated by the "one-shot" circuit 28 and, after it stabilizes, transmits a signal for the remainder of the 0.5 second hold period. The output signal from the transmitter 32 runs to signal electrodes 34 (also see FIG. 1) which are in contact with the patient's skin and electrically couple the transmitter 32 output to the patient's body. The electrical signal, generated by the FSK transmitter 32, is conducted by electrodes 34 to the patient's skin and travels through the patient's body to be received by a remotely located stimulation module 18. It should be noted that any type of alternating electrical signal can be conducted through the human body in the manner disclosed above. This technique is more fully described in co-pending U.S. application entitled "Intracorporeal and/or Extracorporeal Biomedical Device Systems Having Two or More Modules," invented by R. E. Fischell, filed of even date herewith, and incorporated by reference. The present inventors contemplate the use of a transmitter in which an appropriate frequency carrier could be modulated, in any manner known in the art, to produce the desired communication signal.
In the second embodiment, not shown in FIG. 2, the transmitting means 24 emits RF electromagnetic radiation through an antenna. At least some of the electromagnetic radiation is propagated outside of the body and is received by an RF receiver contained in the stimulation module. An RF transmitter and receiver as described above, are of a design known in the communication art.
The sensor module 14 may contain an interrogatable event counter means 36 for diagnostic purposes. The event counter means 36, shown in FIG. 2, obtains its input from the "one-shot" circuit 28 and thus counts the occurrence of each self-injurious blow. The event counter means 36 obtains a timing input from the clock 30 and the time of occurrence of each self-injurious blow is also recorded. An interrogatable input line 38 from an external monitoring device (not shown) can cause the data recorded in the event counter means to be read out on line 40 into such an external monitoring device. Alternatively, the event counter means 36 itself, might have displayed on it (e.g., by an LED display) the data relative to numbers and time of occurrence of acceleration events.
In the apparatus illustrated in FIG. 1, the sensing module 14, and signal electrodes 34, are mounted on an elastic headband 16. The signal electrodes 34 are located on the inner surface of the elastic band 16 and make electrical contact with the patient's skin.
It is also within the contemplation of this invention to mount the sensor module 14 in a protective means mounted on the patient's head which shields the patient's head from self-injurious blows. When the sensor module is mounted in such a protective means, conducting electrodes are placed on the inner surface of the protecting means so as to make good electrical contact with the patient's skin.
FIG. 5 is a block diagram showing the stimulation module 18. Stimulation module 18 is made from a hybrid circuit containing (CMOS) integrated circuits chosen for their low voltage requirement and low electric power drain. The stimulation module 18 consists of a receiving means 42 and a stimulation means 44. The receiving means 42 has two preferred embodiments. The first embodiment (shown in FIG. 5) receives and demodulates electrical signals sent through the patient's body. This embodiment contains: a detector electrode 46, a signal detection and demodulation circuit 48, a "set on-time" circuit 50, or its equivalent, and a battery (not shown). The detecting and modulation circuit 48 is of a typical design known in the communication art. The electrical signal is picked up by the detecting electrode 46 which is placed in contact with the patient's skin. The detecting electrode 46 connects to the detecting and demodulation circuit 48 which demodulates the electrical signal. When the event information indicates that self-injurious action has occurred, the "set-on time" circuit 50 is triggered. Once the "set-on time" circuit 50 is triggered, power is supplied to the constant current inverter 52 for a set period of time. This set period of time defines the length of the aversive stimulation and is controlled by adjusting potentiometer 54 in the "set-on time" circuit 50. It is recommended that the "on-time" be adjusted between 0.2 and 2.0 seconds.
The second embodiment of the receiving means (not shown in FIG. 5) includes a small antenna and a miniaturized radio receiver tuned to the frequency transmitted by the radio transmitter in the sensor module. The receiver is of a typical design known in the communication art. The detected signal is demodulated and the "set-on time" circuit 50 is triggered, as described above.
The stimulation means 44, shown in FIG. 5, consists of a constant current inverter 52 and stimulation electrodes 56. The current is supplied to the constant current inverter 52 from the "set-on time" circuit 50 as described previously. The constant current inverter 52 delivers a current to the stimulation electrodes 56, which are held in contact with the patient's skin. The constant current inverter 52 should be set to deliver stimulation current in a range from 1 to 100 milliamperes, and the frequency of stimulation should be adjustable. The potentiometer 58 on the constant current inverter 52 allows the amplitude of the aversive stimulation to be adjusted to a minimum value that accomplishes the intended purpose of deterring self-injurious behavior.
As shown in FIG. 1, the stimulation module 18 can be mounted on an elastic arm band 20. The stimulation electrodes 56, and the detecting electrode 46 are placed on the inside surface of the arm band so as to make contact with the patient's skin. The stimulation module may alternatively be mounted on other body members and may alternatively be mounted by means other than an elastic band.
As illustrated in FIG. 5, an interrogatable event counter means 60 is connected to the output of the constant current inverter 52. The event counter means 60 provides a record of the number of times that the constant current inverter 52 was activated. The event counter means in 60 is similar in design function and use to the event counter means 36 associated with the sensor module 14 of FIG. 2. The event counter means 36 includes the use of line 62 to initiate interrogation and line 64 for data readout into an external monitoring device (which is not shown). A clock 66 provides timing input for the event counter 66 so that the relative time of each aversive stimulation can be recorded.
In operation, one or more sensor modules would be worn by the patient. Any impact to a sensed body member (which sensed member might include the part of the body that is doing the striking) causing an acceleration greater than 2 g's for a duration of 1.0 millisecond will be sensed as a self-injurious event. The transmitting means 24 included in the sensor module 14 will transmit a signal to a remotely placed simulation module 18. Two embodiments have been described for the transmitter means. In one embodiment the signal containing event information is transmitted through the body. In the other embodiment the signal is transmitted by conventional radio propagation. The stimulation module 18 is mounted on a different body member from the sensor module 14 and contains a receiving means 42 which detects and demodulates the signal transmitted from the sensor module 14. There are two possible embodiments of the receiver means. In one embodiment the receiver detects an electric signal transmitted through the body. In the other embodiment the receiver recovers signals transmitted by conventional radio propagation. The receiving means 42 detects and demodulates the signal. With the occurrence of self-injurious behavior, the "set-on time" circuit 50 is activated. The "set-on time" circuit 50 in turn powers the constant current inverter 52 which supplies an alternating electric current to the patient' s body through the stimulation electrodes 56, which are in contact with the patient's skin. The potentiometers 54, and 58, allow the duration and amplitude respectively of the aversive electrical current to be adjusted. In this manner, an aversive stimulation is supplied to a remote portion of the patient's body in response to a blow sustained by the head or other body member.
In another embodiment, a plurality of sensor modules can be mounted on other body members to detect injurious impacts to those body members or delivered by a particular body member. For illustration, FIG. 1 shows a sensor module 14 mounted on the patient's head and also a sensor module 68 mounted on the patient's right arm. Both sensor modules 14 and 68 are worn simultaneously and communicate to the stimulation module subsystem 12. Sensor modules can simultaneously be placed on the patient's head, arms, legs, elbows or knees, or other body parts depending on the form of injurious behavior a particular patient exhibits.
Obviously many modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3460123 *||14 Jul 1965||5 Aug 1969||Bass Jack V||Clothing alarm means|
|US3508235 *||18 Apr 1967||21 Apr 1970||Baisden Joyce B||Combined diaper fastener and signalling device|
|US3834379 *||25 Sep 1972||10 Sep 1974||Grant M||Deterrent for self-destructive actions|
|US3850161 *||9 Apr 1973||26 Nov 1974||Liss S||Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like|
|US3885576 *||23 Sep 1974||27 May 1975||Habi Chek Corp||Wrist band including a mercury switch to induce an electric shock|
|US3998209 *||16 Dec 1975||21 Dec 1976||Macvaugh Gilbert S||Snoring deconditioning system and method|
|US4048986 *||5 Aug 1976||20 Sep 1977||Novar Electronics Corporation||Individual identification and diagnosis using wave polarization|
|US4163449 *||30 Sep 1977||7 Aug 1979||Regal Robert A||Enuresis treatment device|
|US4203098 *||18 Sep 1978||13 May 1980||Muncheryan Hrand M||Device for preventing dozing while driving a car|
|US4292630 *||22 Mar 1979||29 Sep 1981||Societe d'Etudes Techniques et Commerciales d'Automation||Device for the obtaining of an electric signal which is proportional to an amount of movement and therefore capable of detecting any movement or acceleration|
|US4359724 *||28 Apr 1980||16 Nov 1982||Ronald R. Zimmerman||Eyelid movement detector|
|SE8101506A *||Title not available|
|1||Friauf; "An Aversive Stimulator for Autistic Children;" Medical and Biological Engineering; vol. 11, No. 5, 9-1973, pp. 609-612.|
|2||*||Friauf; An Aversive Stimulator for Autistic Children; Medical and Biological Engineering; vol. 11, No. 5, 9 1973, pp. 609 612.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4524773 *||24 Aug 1983||25 Jun 1985||The John Hopkins University||Apparatus for inhibiting self-injurious behavior (SIB) in patients|
|US4715367 *||15 Sep 1986||29 Dec 1987||Crossley Robert B||Multifunctional behavioral modification device for snoring, bruxism, and apnea|
|US4965553 *||27 Apr 1989||23 Oct 1990||Delbiondo Ii Thomas||Hand-near-mouth warning device|
|US5054428 *||17 Nov 1989||8 Oct 1991||Tri-Tronics, Inc.||Method and apparatus for remote conditioned cue control of animal training stimulus|
|US5123425 *||6 Sep 1990||23 Jun 1992||Edentec||Obstructive sleep apnea collar|
|US5265624 *||19 May 1992||30 Nov 1993||Edentec||Stimulation collar|
|US5304211 *||25 Nov 1991||19 Apr 1994||Behavior Research Institute||Apparatus for administering electrical aversive stimulus and associated method|
|US5477867 *||19 Jan 1995||26 Dec 1995||Balkanyi; Alexander||Device for the suppression of snoring|
|US5559498 *||30 Dec 1994||24 Sep 1996||Innotek Inc.||Combination confinement and remote training system|
|US5815077 *||20 Nov 1996||29 Sep 1998||B.E.R.T.S. Inc.||Electronic collar for locating and training animals|
|US5913284 *||27 Feb 1996||22 Jun 1999||Innotek, Inc.||Stimulation device and technique|
|US5978972 *||11 Jun 1997||9 Nov 1999||Johns Hopkins University||Helmet system including at least three accelerometers and mass memory and method for recording in real-time orthogonal acceleration data of a head|
|US6063108 *||6 Jan 1997||16 May 2000||Salansky; Norman||Method and apparatus for localized low energy photon therapy (LEPT)|
|US6073589 *||16 Mar 1998||13 Jun 2000||Innotek, Inc.||Stimulation device and technique|
|US6118882 *||25 Jan 1996||12 Sep 2000||Haynes; Philip Ashley||Communication method|
|US6334073 *||10 Dec 1999||25 Dec 2001||Robert A. Levine||Internal monitoring and behavior control system|
|US6494900||31 Jan 2000||17 Dec 2002||Norman Salansky||Method for localized low energy photon therapy (LEPT)|
|US6735477||9 Jul 2001||11 May 2004||Robert A. Levine||Internal monitoring system with detection of food intake|
|US6762687||20 Jun 2002||13 Jul 2004||David Perlman||Biofeedback device for treating obsessive compulsive spectrum disorders (OCSDs)|
|US7476102||9 Jun 2006||13 Jan 2009||Maples Paul D||Contamination avoiding device|
|US7887533||30 Oct 2007||15 Feb 2011||Clinique Dr Daniel Barolet Inc.||Device for the treatment of mammalian tissues|
|US7914523||7 Feb 2005||29 Mar 2011||Clinique Dr Daniel Barolet Inc.||Method for the treatment of mammalian tissues|
|US8417351 *||8 Feb 2008||9 Apr 2013||Mayo Foundation For Medical Education And Research||Peripheral oxistimulator apparatus and methods|
|US8548768||9 Jan 2006||1 Oct 2013||Riddell, Inc.||System and method for evaluating and providing treatment to sports participants|
|US8554509 *||24 Nov 2004||8 Oct 2013||Riddell, Inc.||System and method for measuring the linear and rotational acceleration of a body part|
|US8579794||1 May 2009||12 Nov 2013||Dymedix Corporation||Agitator to stimulate the central nervous system|
|US8585588||18 Nov 2010||19 Nov 2013||Nohands, Llc||Method and system for preventing virus-related obesity and obesity related diseases|
|US8591412||18 Nov 2010||26 Nov 2013||Nohands, Llc||Method and system for preventing virus-related obesity and obesity related diseases|
|US8797165||13 Sep 2005||5 Aug 2014||Riddell, Inc.||System for monitoring a physiological parameter of players engaged in a sporting activity|
|US8834346||21 Aug 2009||16 Sep 2014||Dymedix Corporation||Stimulus sequencer for a closed loop neuromodulator|
|US8834347||21 Aug 2009||16 Sep 2014||Dymedix Corporation||Anti-habituating sleep therapy for a closed loop neuromodulator|
|US20040102819 *||18 Nov 2003||27 May 2004||Shazhou Zou||Portable therapeutic device and method for pain relief|
|US20050177335 *||24 Nov 2004||11 Aug 2005||Riddell, Inc.||System and method for measuring the linear and rotational acceleration of a body part|
|US20050197681 *||7 Feb 2005||8 Sep 2005||Lumiphase Inc.||Method and device for the treatment of mammalian tissues|
|US20060074338 *||13 Sep 2005||6 Apr 2006||Greenwald Richard M||System for monitoring a physiological parameter of players engaged in a sporting activity|
|US20060189852 *||9 Jan 2006||24 Aug 2006||Greenwald Richard M||System and method for evaluating and providing treatment to sports participants|
|WO1992003983A1 *||14 Aug 1991||19 Mar 1992||Edentec||Obstructive sleep apnea collar|
|WO1996023373A1 *||25 Jan 1996||1 Aug 1996||Philip Ashley Haynes||Communication method|
|WO2008015405A1 *||27 Jul 2007||7 Feb 2008||Ghazala Tabasam||An electrical stimulator|
|U.S. Classification||128/846, 607/58, 128/857|
|19 Jan 1982||AS||Assignment|
Owner name: JOHNS HOPKINS UNIVERSITY,THE, BALTIMORE, MD. A COR
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:FISCHELL, ROBERT E.;FOUNTAIN, GLEN H.;BLACKBURN, CHARLES M.;REEL/FRAME:003961/0301
Effective date: 19820105
|12 Aug 1987||FPAY||Fee payment|
Year of fee payment: 4
|22 Aug 1991||FPAY||Fee payment|
Year of fee payment: 8
|25 Sep 1995||FPAY||Fee payment|
Year of fee payment: 12