US3790648A - Process for the manufacture of benzylphosphonates - Google Patents
Process for the manufacture of benzylphosphonates Download PDFInfo
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- US3790648A US3790648A US00225615A US3790648DA US3790648A US 3790648 A US3790648 A US 3790648A US 00225615 A US00225615 A US 00225615A US 3790648D A US3790648D A US 3790648DA US 3790648 A US3790648 A US 3790648A
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- phosphite
- carbon atoms
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- 238000000034 method Methods 0.000 title abstract description 33
- 238000004519 manufacturing process Methods 0.000 title abstract description 15
- OGBVRMYSNSKIEF-UHFFFAOYSA-N Benzylphosphonic acid Chemical class OP(O)(=O)CC1=CC=CC=C1 OGBVRMYSNSKIEF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000003381 stabilizer Substances 0.000 abstract description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 23
- -1 benzyl halides Chemical class 0.000 description 22
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 21
- 125000000217 alkyl group Chemical group 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 239000002585 base Substances 0.000 description 11
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 8
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 8
- 239000003513 alkali Substances 0.000 description 8
- 125000000753 cycloalkyl group Chemical group 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 7
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 6
- LXCYSACZTOKNNS-UHFFFAOYSA-N diethoxy(oxo)phosphanium Chemical compound CCO[P+](=O)OCC LXCYSACZTOKNNS-UHFFFAOYSA-N 0.000 description 6
- 229960000583 acetic acid Drugs 0.000 description 5
- 125000005037 alkyl phenyl group Chemical group 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 239000012362 glacial acetic acid Substances 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 150000001350 alkyl halides Chemical class 0.000 description 4
- 125000006487 butyl benzyl group Chemical group 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000006350 alkyl thio alkyl group Chemical group 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 description 3
- CDXVUROVRIFQMV-UHFFFAOYSA-N oxo(diphenoxy)phosphanium Chemical compound C=1C=CC=CC=1O[P+](=O)OC1=CC=CC=C1 CDXVUROVRIFQMV-UHFFFAOYSA-N 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000001953 recrystallisation Methods 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VGUWZCUCNQXGBU-UHFFFAOYSA-N 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1h-indole Chemical compound C1CN(C)CCN1CC1=CNC2=CC=C([N+]([O-])=O)C=C12 VGUWZCUCNQXGBU-UHFFFAOYSA-N 0.000 description 2
- LCWKIAHCEIHHJE-UHFFFAOYSA-N 4-[(dimethylamino)methyl]-2,6-dimethylphenol Chemical compound CN(C)CC1=CC(C)=C(O)C(C)=C1 LCWKIAHCEIHHJE-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 150000003938 benzyl alcohols Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000006165 cyclic alkyl group Chemical group 0.000 description 2
- 150000005690 diesters Chemical class 0.000 description 2
- BAKDLAFAVHBXHW-UHFFFAOYSA-N dioctadecyl phosphite Chemical compound CCCCCCCCCCCCCCCCCCOP([O-])OCCCCCCCCCCCCCCCCCC BAKDLAFAVHBXHW-UHFFFAOYSA-N 0.000 description 2
- 125000001188 haloalkyl group Chemical group 0.000 description 2
- 150000004678 hydrides Chemical class 0.000 description 2
- 150000004694 iodide salts Chemical class 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 229910000104 sodium hydride Inorganic materials 0.000 description 2
- ZHBRSHSRMYZHLS-UHFFFAOYSA-N (4-hydroxyphenyl)methylphosphonic acid Chemical class OC1=CC=C(CP(O)(O)=O)C=C1 ZHBRSHSRMYZHLS-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 239000001733 1,4-Heptonolactone Substances 0.000 description 1
- YXYYZPDGOACFLV-UHFFFAOYSA-N 1-diethoxyphosphorylpentylbenzene Chemical compound CCCCC(P(=O)(OCC)OCC)C1=CC=CC=C1 YXYYZPDGOACFLV-UHFFFAOYSA-N 0.000 description 1
- HECLRDQVFMWTQS-RGOKHQFPSA-N 1755-01-7 Chemical compound C1[C@H]2[C@@H]3CC=C[C@@H]3[C@@H]1C=C2 HECLRDQVFMWTQS-RGOKHQFPSA-N 0.000 description 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- NBGHWWFWFLNKMX-UHFFFAOYSA-N 4-(diethoxyphosphorylmethyl)-2,6-di(propan-2-yl)phenol Chemical compound CCOP(=O)(OCC)CC1=CC(C(C)C)=C(O)C(C(C)C)=C1 NBGHWWFWFLNKMX-UHFFFAOYSA-N 0.000 description 1
- BWGGHVNBXBGKOF-UHFFFAOYSA-N 4-(diethoxyphosphorylmethyl)-2,6-dimethylphenol Chemical compound CCOP(=O)(OCC)CC1=CC(C)=C(O)C(C)=C1 BWGGHVNBXBGKOF-UHFFFAOYSA-N 0.000 description 1
- RQJDUEKERVZLLU-UHFFFAOYSA-N 4-Hydroxybenzylamine Chemical class NCC1=CC=C(O)C=C1 RQJDUEKERVZLLU-UHFFFAOYSA-N 0.000 description 1
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 125000004965 chloroalkyl group Chemical group 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- BVXOPEOQUQWRHQ-UHFFFAOYSA-N dibutyl phosphite Chemical compound CCCCOP([O-])OCCCC BVXOPEOQUQWRHQ-UHFFFAOYSA-N 0.000 description 1
- KDFMYTBUQJDSOY-UHFFFAOYSA-N didocosyl hydrogen phosphite Chemical compound CCCCCCCCCCCCCCCCCCCCCCOP(O)OCCCCCCCCCCCCCCCCCCCCCC KDFMYTBUQJDSOY-UHFFFAOYSA-N 0.000 description 1
- QBCOASQOMILNBN-UHFFFAOYSA-N didodecoxy(oxo)phosphanium Chemical compound CCCCCCCCCCCCO[P+](=O)OCCCCCCCCCCCC QBCOASQOMILNBN-UHFFFAOYSA-N 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- IEXRYDPZNWLKLE-UHFFFAOYSA-N dihexadecoxy(oxo)phosphanium Chemical compound CCCCCCCCCCCCCCCCO[P+](=O)OCCCCCCCCCCCCCCCC IEXRYDPZNWLKLE-UHFFFAOYSA-N 0.000 description 1
- XFUSKHPBJXJFRA-UHFFFAOYSA-N dihexyl hydrogen phosphite Chemical compound CCCCCCOP(O)OCCCCCC XFUSKHPBJXJFRA-UHFFFAOYSA-N 0.000 description 1
- CZHYKKAKFWLGJO-UHFFFAOYSA-N dimethyl phosphite Chemical compound COP([O-])OC CZHYKKAKFWLGJO-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- SJYNFBVQFBRSIB-UHFFFAOYSA-N norbornadiene Chemical compound C1=CC2C=CC1C2 SJYNFBVQFBRSIB-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- 150000003388 sodium compounds Chemical class 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/49—Phosphorus-containing compounds
- C08K5/51—Phosphorus bound to oxygen
- C08K5/53—Phosphorus bound to oxygen bound to oxygen and to carbon only
- C08K5/5317—Phosphonic compounds, e.g. R—P(:O)(OR')2
- C08K5/5333—Esters of phosphonic acids
Definitions
- ABSTRACT OF THE DISCLOSURE Process for the manufacture of 4-hydroxybenzylphosphonic esters by reacting esters of phosphoric acid with 4-hydroxybenzylamines in the presence of a base.
- the compounds manufactured according to the invention are used as stabilizers.
- the present invention relates to a process for the manufacture of compounds of the Formula I I O R4 R:
- R and R denote a straight-chain or branched alkyl group, a cycloalkyl group or an aralkyl group
- R and R independently of one another denote a straightchain or branched alkyl group, a cycloalkyl group, an alkylthioalkyl group, an alkyloxalalkyl group, a halogenoalkyl group, an alkenyl group, the phenyl group or an alkylphenyl group, or together denote the groups characterized in that 1 mol of a compound of the Formula II I Ra B2 wherein R and R 'halve the abovementioned meaning and R and R independently of one another denote a straight-chain or branched alkyl group or together, and with inclusion of the nitrogen atom, denote a saturated "United States Patent ihce 3,790,648 Patented Feb.
- dialkylamines split off during the reaction can easily be removed because of their volatility and can furthermore be trapped and reemployed for the manufacture of the starting products of the Formula II, which represents a further advantage in dustrially.
- dialkyl phosphites used in the heterocyclic ring are reacted with one mol of a compound 7 of the Formula HI E O R4 (III) wherein R and B, have the aboven entioned meaning in the presence of a base.
- R and R independently of one another denote a straight-chain or branched alkyl group with 1 to 8 carbon atoms or a cycloalkyl group with *6 to 8 carbon atoms and R and R independently of one another denote a straight-chain or branched alkyl group with 1-22 carbon atoms, a cycloalkyl group with 6-8 carbon atoms, the groups wherein the alkyl groups possess 1-18 carbon atoms, the phenyl group or an alkylphenyl group with 7-14 carbon atoms.
- dialkyl In the preferred embodiment of the process according to the invention, compounds of the Formula II are used in which R and R independently of one another denote a straight-chain or branched alkyl group with 1 to 5 carbon atoms or together, with inclusion of the nitrogen atom, form a hydrogenated heterocyclic S-membered or 6-membered ring.
- R denotes methyl or branched alkyl with 3-4 carbon atoms
- R denotes branched alkyl with 3 or 4 carbon atoms
- R and R denote straight-chain or branched alkyl groups with 1-18 carbon atoms.
- Compounds ofthe Formula II in which R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine or morpholine are particularly preferentially employed for the manufacture of the compounds of the Formula I.
- the process according to the invention can be carried out in the absence or in the presence of a solvent. Preferably, no solvent is used.
- R R R R R and R represent alkyl groups, these can, within the framework of the limits which have been indicated, be methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertbutyl, amyl, tert.arnyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, hexadecyl, octdecyl, eicosyl or docosyl.
- These groups may also be alkyl substituents if R and R denote alkylphenyl.
- R and R are halogenoalkyl groups, then these are preferably chloroalkyl groups with 1-18 carbon atoms, such as, for example, 2-chloroethyl.
- R and R can also be cyclic alkyl groups with 6 to 8 carbon atoms. These can be, for example, cyclohexyl, cycloheptyl or cyclooctyl, and the preferred cyclic alkyl group is the l-methylcyclo- Preferred'temperature ranges are 60-120 C.
- R and R are aralkyl groups, these can be groups with 7-12 carbon atoms, such as benzyl or phenylethyl. If R and R with inclusion of the nitrogen atom, form a heterocyclic S-membered or 6-membered ring, then this can be, for example, the radical of morpholine or piperidine.
- R is alkylthioalkyl, it can be hexadecylthioethyl, dodecylthioethyl, hexylthioethyl, octadecylthiopropyl, dodecylthiopropyl or hexylthiopropyl.
- R;., denotes alkyloxalalkyl this can be octadecyloxyethyl or dodecyloxyethyl.
- R as alkenyl is, for example, allyl.
- solvents are used in the process according tov the invention, then these can be aromatic hydrocarbons such as benzene or toluene, higher-boiling ethers, such as dioxane or ethylene glycol dimethyl ether, or aliphatic hydrocarbons or hydrocarbon mixtures, such as ligroin.
- Bases in the process according to the invention are, for example, alkali amides such as LlNHg or NaNI-I alkali hydrides, such as NaH or Lil-I, alkali hydroxides, such as LiII-I, NaOH or KOH, alcoholates such as NaOCI-I NaOC H or Mg(OC H Alkali amides and alkali alcoholates are preferred.
- Alkali compounds of the phosphites of the Formula 111 can also be employed as bases. Their manufacture is effected, for example, by adding an alkali metal such as sodium to a phosphite of the Formula III.
- Examples of compounds of the Formula III are dimethyl phosphite, diethyl phosphite, dibutyl phosphite, dihexyl phosphite, di-Z-ethylhexyl phosphite,- dioctyl phospite, didodecyl phosphite, dihexadecyl phosphite, dioctadecyl phosphite, didocosyl phosphite, diphenyl phosphite I or di-p-octylphenyl phosphite.
- the starting compounds of the Formula II canbe manufactured from the corresponding 2,6-dialkylphenol, formaldehyde and a secondary amine HNR R as described, for example, in Netherlands Pat. 6803498.
- the reactants of the Formulae II and III are advantageously employed in molar ratios.
- one of the two reactants can be used in an excess of up to 20%.
- The-base is employed in amounts of 1-30 mol percent, preferably 5-10 mol percent, relative to one of the reactants ofcthe Formula II or III. 4
- the temperature in the process according to the invention are not critical. They are only important with re- If, for example, the reaction is carried out at 100 C
- the reaction according to the invention is preferably carried out under nitrogen or a noble gas, at normal pressure or reduced presusre, such as, for example, 10- mm. Hg.
- the reaction according to the invention can be carried out, for example, by warming the Compounds 11 and III and the base, withoutsolvents, under reduced p ressure'until no further amine is evolved, or by adding the base 'to a solution of the Compound III and then adding the compound II, in the same solvent as the CompoundIH, at elevated temperature.
- the compounds obtained in accordance with the process of the invention are outstandingly suitable for use as stabilizers against the thermo-oxidative and/or photo-induced degradation of monomeric and polymeric substances, especially for the stabilization of polypropylene, of polyethylene, of polyamides, of polyacetals or of copolymers of ethylene, propylene and a diene such as, for example, norbornadiene or dicyclopentadiene.
- the diphenyl phosphite is replaced by an equimolecular amount of di-tert.octylphenyl phosphite and otherwise the same procedure is followed, 4- hydroxy-3,5-di-tert.butylbenzyl-phosphonic acid di-(tert. octylphenyl) ester is obtained in good yield, after distilling off the solvent, as a glass of a slight yellow color.
- Process for the manufacture of compounds of the Formula I ii OR -onionlor which comprises reacting 1 mol of a compound of the Formula II HQ-QCm-N wherein R and R have the'abovementioned meaning and R and R independently of one another denote a straight-chain or branched alkyl group or together, and with inclusion of the nitrogen atom, denote a saturated heterocyclic ring, with one mol of a compound of the Formula III wherein R and R have the abovementioned meaning, in the presence of a base selected from alkali amides, alkali hydrides, alkali hydroxides, alkali alcoholates, and alkali compounds of the phosphites of the Formula III.
- R and R denote a straight-chain or branched alkyl group or a cycloalkyl group and R and R inde: pendently of one another denote a straight-chain or branched alkyl group, a cycloalkyl group, an alkylthioalkyl group, an alkyloxalkyl group, an alkenyl group, the phenyl group or an alkylphenyl group or together denote the groups -omomor 3.
- R and R independently of one another denote a straight-chain or branched alkyl group with 1 to 8 carbon atoms or a cycloalkyl group with 6 to 8 carbon atoms and R and R independently of one another denote a straight-chain or branched alkyl group with 1-22 carbon atoms,a cycloalkyl group with 6-8 carbon atoms, the --(CH -Sall yl or (CH 0alkyl groups, wherein the alkyl groups contain 1-18 carbon atoms, the phenyl group or an alkylphenyl group with 7-14 carbon atoms.
- R and R independently of one another denote. alkylwith 1-5 carbon atoms or together and with inclusion of the nitrogen atom form a hydrogenated heterocyclic S-membered or fi-rnembered ring.
- R denotes methyl or branched alkyl with 3-4 carbon atoms
- R denotes branched alkyl with 3 or 4 carbon atoms
- R and R denote straight-chain or branched alkyl groups with 1-18 carbon atoms.
- R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine or morpholine.
- R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine.
Abstract
PROCESS FOR THE MANUFACTURE OF 4-HYDROXYBENZYLPHOSPHONIC ESTER BY REACTING ESTERS OF PHOSPHORIC ACID WITH 4-HYDROXYBENZYLAMINES IN THE PRESENCE OF A BASE. THE COMPOUNDS MANUFACTURED ACCORDING TO THE INVENTION ARE USED AS STABILIZERS.
Description
ABSTRACT OF THE DISCLOSURE Process for the manufacture of 4-hydroxybenzylphosphonic esters by reacting esters of phosphoric acid with 4-hydroxybenzylamines in the presence of a base. The compounds manufactured according to the invention are used as stabilizers.
The present invention relates toa process for the manufacture of compounds of the Formula I I O R4 R:
wherein R and R denote a straight-chain or branched alkyl group, a cycloalkyl group or an aralkyl group, R and R independently of one another denote a straightchain or branched alkyl group, a cycloalkyl group, an alkylthioalkyl group, an alkyloxalalkyl group, a halogenoalkyl group, an alkenyl group, the phenyl group or an alkylphenyl group, or together denote the groups characterized in that 1 mol of a compound of the Formula II I Ra B2 wherein R and R 'halve the abovementioned meaning and R and R independently of one another denote a straight-chain or branched alkyl group or together, and with inclusion of the nitrogen atom, denote a saturated "United States Patent ihce 3,790,648 Patented Feb. 5, 1974 phosphite of the Formula IH which is employed is almost completely incorporated into the end product of the Formula I, whereas according to the previously known process a part of the trialkyl phosphite is lost in the form of the alkyl halide. The fact that the splitting ofr of an alkyl halide is avoided in the process according to the invention also signifies a technological advance inasmuch as alkyl halides, especially lower alkyl halides, have to be destroyed by combustion, where, because of the halogen content, expensive absorption installations are needed to avoid contaminating the atmosphere. Finally, the substituted benzyl halides required for the previously known manufacturing process are unstable compounds of poor stability on storage, whilst the starting products of the Formula II required for the process according to the invention are stable compounds which can be stored.
It is furthermore known to manufacture compounds of the Formula I by reaction of appropriately substituted benzyl alcohols with trialkyl phosphites or triaryl phosphites, whilst splitting oif alcohols or phenols, respectively. The benzyl alcohols required for this are however industrially more difiicult to obtain than the starting products of the Formula H required for the process according to the invention. In other respects, what has been stated above applies as regards the more advantageous use of dialkyl phosphites in accordance with the process of the invention.
Finally it is known to manufacture compounds of the Formula I by reaction of appropriately substituted benzyltrialkylammonium iodides with trialkyl phosphites in the sense of a modified Arbusow reaction. However, the manufacture of the benzyltrialkylammonium iodides requires a further process stage as compared to the starting products of the Formula II which can be used according to the invention. In other respects, this process suffers from the same disadvantages as the Arbusow reaction of benzyl halides with trialkyl phosphites, described above.
Further general advantages of the process according to the invention are the relatively low reaction temperatures and the short reaction times, which repress the undesired L formation of colored by-products. The dialkylamines split off during the reaction can easily be removed because of their volatility and can furthermore be trapped and reemployed for the manufacture of the starting products of the Formula II, which represents a further advantage in dustrially. Furthermore, the dialkyl phosphites used in the heterocyclic ring, are reacted with one mol of a compound 7 of the Formula HI E O R4 (III) wherein R and B, have the aboven entioned meaning in the presence of a base.
It is known to manufacture p-hydroxybenzylphosphonates by reaction of appropriately substituted benzyl halides with trialkyl phosphites in the sense of an Arbusow process according to the invention are substantially less volatile than the corresponding trialkyl phosphites hitherto used and therefore produce a distinctly less objectionable odor during the reaction.
'According to the invention, it is preferred to manufacture compounds of the Formula I in which R and R independently of one another denotea straight-chain or branched alkyl group with 1 to 8 carbon atoms or a cycloalkyl group with *6 to 8 carbon atoms and R and R independently of one another denote a straight-chain or branched alkyl group with 1-22 carbon atoms, a cycloalkyl group with 6-8 carbon atoms, the groups wherein the alkyl groups possess 1-18 carbon atoms, the phenyl group or an alkylphenyl group with 7-14 carbon atoms.
invention is economically advantageous 'since the dialkyl In the preferred embodiment of the process according to the invention, compounds of the Formula II are used in which R and R independently of one another denote a straight-chain or branched alkyl group with 1 to 5 carbon atoms or together, with inclusion of the nitrogen atom, form a hydrogenated heterocyclic S-membered or 6-membered ring.
It is particularly preferred, according to the invention, to manufacture compounds of the Formula I in which R; denotes methyl or branched alkyl with 3-4 carbon atoms, R; denotes branched alkyl with 3 or 4 carbon atoms and R and R denote straight-chain or branched alkyl groups with 1-18 carbon atoms. Compounds ofthe Formula II in which R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine or morpholine are particularly preferentially employed for the manufacture of the compounds of the Formula I.
The process according to the invention can be carried out in the absence or in the presence of a solvent. Preferably, no solvent is used.
If R R R R R and R represent alkyl groups, these can, within the framework of the limits which have been indicated, be methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertbutyl, amyl, tert.arnyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, hexadecyl, octdecyl, eicosyl or docosyl. These groups may also be alkyl substituents if R and R denote alkylphenyl. If R and R are halogenoalkyl groups, then these are preferably chloroalkyl groups with 1-18 carbon atoms, such as, for example, 2-chloroethyl. R and R can also be cyclic alkyl groups with 6 to 8 carbon atoms. These can be, for example, cyclohexyl, cycloheptyl or cyclooctyl, and the preferred cyclic alkyl group is the l-methylcyclo- Preferred'temperature ranges are 60-120 C.
hexyl-(l) group. If R and R are aralkyl groups, these can be groups with 7-12 carbon atoms, such as benzyl or phenylethyl. If R and R with inclusion of the nitrogen atom, form a heterocyclic S-membered or 6-membered ring, then this can be, for example, the radical of morpholine or piperidine.
If R is alkylthioalkyl, it can be hexadecylthioethyl, dodecylthioethyl, hexylthioethyl, octadecylthiopropyl, dodecylthiopropyl or hexylthiopropyl. If R;., denotes alkyloxalalkyl, this can be octadecyloxyethyl or dodecyloxyethyl. R as alkenyl is, for example, allyl.
If solvents are used in the process according tov the invention, then these can be aromatic hydrocarbons such as benzene or toluene, higher-boiling ethers, such as dioxane or ethylene glycol dimethyl ether, or aliphatic hydrocarbons or hydrocarbon mixtures, such as ligroin. Bases in the process according to the invention are, for example, alkali amides such as LlNHg or NaNI-I alkali hydrides, such as NaH or Lil-I, alkali hydroxides, such as LiII-I, NaOH or KOH, alcoholates such as NaOCI-I NaOC H or Mg(OC H Alkali amides and alkali alcoholates are preferred.
Alkali compounds of the phosphites of the Formula 111 can also be employed as bases. Their manufacture is effected, for example, by adding an alkali metal such as sodium to a phosphite of the Formula III.
Examples of compounds of the Formula III are dimethyl phosphite, diethyl phosphite, dibutyl phosphite, dihexyl phosphite, di-Z-ethylhexyl phosphite,- dioctyl phospite, didodecyl phosphite, dihexadecyl phosphite, dioctadecyl phosphite, didocosyl phosphite, diphenyl phosphite I or di-p-octylphenyl phosphite.
The starting compounds of the Formula II canbe manufactured from the corresponding 2,6-dialkylphenol, formaldehyde and a secondary amine HNR R as described, for example, in Netherlands Pat. 6803498.
In the process according to the invention, the reactants of the Formulae II and III are advantageously employed in molar ratios. Optionally, one of the two reactants can be used in an excess of up to 20%. The-base is employed in amounts of 1-30 mol percent, preferably 5-10 mol percent, relative to one of the reactants ofcthe Formula II or III. 4
The temperature in the process according to the invention are not critical. They are only important with re- If, for example, the reaction is carried out at 100 C The reaction according to the invention is preferably carried out under nitrogen or a noble gas, at normal pressure or reduced presusre, such as, for example, 10- mm. Hg. The reaction according to the invention can be carried out, for example, by warming the Compounds 11 and III and the base, withoutsolvents, under reduced p ressure'until no further amine is evolved, or by adding the base 'to a solution of the Compound III and then adding the compound II, in the same solvent as the CompoundIH, at elevated temperature.
The compounds obtained in accordance with the process of the invention are outstandingly suitable for use as stabilizers against the thermo-oxidative and/or photo-induced degradation of monomeric and polymeric substances, especially for the stabilization of polypropylene, of polyethylene, of polyamides, of polyacetals or of copolymers of ethylene, propylene and a diene such as, for example, norbornadiene or dicyclopentadiene.
The invention is explained in more detail in the examples which follow:
'4 EX'A' MPLE I I)l CzHa0\ )0 /C s /P\ no CH N\ (121150 H CH8 C(CHa):
0 0CgH5 HQ- -orn OCzHa 2):
13.8 g. (0.1 mol) of diethyl-phosphite are initially introduced into 100ml. of toluene and 0.69 g. (0.03 mol) of metallic sodium is added. The temperature rises to 40 C. whilst the sodium dissolves. The solution is treated with 26.3 g. (0.1 mol) of (4-hydroxy-3,5-di-tert.butylbenzyl)-dimethylamine in ml. of toluene and the mixture is boiled for one hour under reflux, in the course of which gaseous dimethylamine is evolved. When the evolution of dimethylamine has ceased, the mixture is cooled, water is added and the toluene phase is washed until neutral and evaporated. The residue is recrystallized from ligroin. 26.8 g. (75%) of 4-hydroxy-3,5-di-tert. butylbenzyl-phosphonic acid diethyl ester of melting point 122 C. arethus obtained.
If in this example the diethyl phosphite is replaced by an equimolecular amount of a phosphorous acid diester of Table I below,-and otherwise the same procedure is followed, the 4-hydroxy-3,5-di-tert.butylbenzylphosphonic acid diesters having the physical properties indicated are obtained in similar yields.
. .TABLE I 4-hydroxy-3,5-di-tert.butylbenzylphosphonic acid diester Boiling point (OlOHzCHzO) PHO 13.8 g. (0.1 mol) of diethyl phosphite and 29.1g; (0.1 mol) of (4-hydroxy-3,5-di-tert.butyl-benzyl)-diethylamine are mixed and heated to 80 C. whilst passing a slight stream of nitrogen through the mixture. After adding 0.1 g. (0.0044 mol) of lithium amide the pressure is reduced to'15 mm. Hg by means of a water pump and the mixture is warmed to 100 C. The evolution of diethylamine can be recognized from the vigorous formation of bubbles. After one hour, 0.3 g. of glacial acetic acid and 50' ml. of ligroin are added. On cooling, 4-hydroxy-3,5-di-tert.butylbenzylphosphonic acid diethyl ester precipitates as a white crystalline substance. Melting point 122 C., yield 32 g. (90%). v
If, in this example, (4-hydroxy-3,S-di-tert.butylbenzyl)-diethylamine is replaced by an equimolecular amount of (3-tert.butyl-4-hfydroxy-S-methyl-benzyl)-diethylamine and the analogous procedure is followed, and various dialkyl phosphites are employed, the (3-tert.butyl- 4-hydroxy-5 methylbenzyl)-phosphonic acid dialkyl esters indicated in Table II are obtained in good yield.
C (CH )3 .a (')/o R3 H O OHa-P l R4 CH3 TABLE II 3-tert.butyl-thydroxy-Em-methylbenzyl-phosphonio acid dialkyl ester Boiling point Melting Dialkyl phosphite C. Mm. point, C.
(CH30)2PHO 102 (C2H50)2PHO 102 (C4Hv-CH-CH2O)2PHO 216 5 (CgHmOhPHO 69-71 EXAMPLE 3 C (CH8)8 0 E370 0 /CH P HO CHI-N CiaHzwO H CH3 2 OC1sHa HO CHaP is a1 ah 29.3 g. (0.05 mol) of dioctadecyl phosphite and 13.3 (0.05 mol) of (4-hydroxy-3,5-di-tert.-butyl-benzyl)-dimethylamine are mixed and heated to 60 C. whilst passing a slight stream of nitrogen through the mixture, whereupon a homogeneous melt is produced. After adding 0.3 g. (0.013 mol) of lithium amide, the pressure is reduced to 15 .mm. Hg by means of a water pump and the mixture is slowly warmed to 100 C., in the course of which the evolution of dimethylamine starts at 80 C. After one hour the mixture is cooled to 50 C. and 1.0 g. of glacial acetic acid is added. On cooling to room temperature, the melt solidifies. After recrystallization from acetone, 35 g. (90%) of 4-hydroxy-3,5-di- 0f the 4-hydroxy-3,5-di-tert.butylbenzy1-phosphonic acid diester.
EXAMPLE 4 C Qs 23.4 g. (0.1 mol) of diphenyl phosphite are initially introduced into 50 ml. of absolute toluene, the solution is cooled to 5 C. and 0.48 g. (0.02 mol) of sodium hydride is added. The mixture is heated to the boil and a solution of 26.3 g. (0.1 mol) of (4-hydroxy-3,5-di-tert. butyl)-dimethylamine in ml. of absolute toluene is added dropwise. Thereafter the mixture is further boiled until the evolution of dimethylamine ceases (approx. 4 hours). After cooling, the mixture is neutralized with a little glacial acetic acid, water is added and the toluene phase is washed until neutral and evaporated. The residue is recrystallized from hexane. 33 g. (73%) of 4- hydroxy-3,5-di-tert.butylbenzyl-phosphonic acid diphenyl ester of melting point C. are thus obtained.
If, in this example, the diphenyl phosphite is replaced by an equimolecular amount of di-tert.octylphenyl phosphite and otherwise the same procedure is followed, 4- hydroxy-3,5-di-tert.butylbenzyl-phosphonic acid di-(tert. octylphenyl) ester is obtained in good yield, after distilling off the solvent, as a glass of a slight yellow color.
13.8 g. (0.1 mol) of diethyl phosphite and 17.9 g. (0.1 mol) of (4-hydroxy-3,5-dimethylbenzyl)-dimethylamine are mixed and heated to 100 C. 0.4 g. (0.01 mol) of sodium methylate is added at this temperature and the pressure is then reduced to 15 mm. Hg. When the reaction has subsided, which requires approx. 1 hour, the mixture is cooled and neutralized with glacial acetic acid. The melt is digested with hexane, whereupon crystallization occurs. After recrystallization from hexane, 4- hydroxy-3,5-dimethylbenzylphosphonic acid diethyl ester is obtained in a yield of 80%. Melting point: 72 C.
If, in this example, the (4-hydroxy-3,5-dimethylbenzyl)-dimethylamine is replaced by an equimolecular 7 amount of (4hydroxy-3,S-diisopropylbenzyl)-dimethylamine and the analogous procedure is followed, 4-hydroxy-3,5-diisopropylbenzyl-phosphonic acid diethyl ester is obtained in a yield of 65%. The substance is liquid and 13.8 g. (0.1 mol) of diethyl phosphite and 30.5 g. of N-(4-hydroxy-3,5-di-tert.butyl-benzyl)-morpholine (melting point 93-94 C.) are mixed and heated to 100 C. under nitrogen. After adding 0.2 g. (0.005 mol) of sodium amide, the pressure is reduced to 15 mm. Hg by means of a water pump and the mixture is kept at 100 C. for 2 hours. When the reaction has subsided, the mixture is cooled and neutralized with a little glacial acetic acid. On treating the reaction mixture with warm ligroin, 4-hydroxy-3,5-di-tert.butyl-benzyl-phosphonie acid diethyl ester precipitates as crystals. Yield 28 g. (80%); melting point, after one recrystallization from ligroin: 122 C.
What is claimed is: I
1. Process for the manufacture of compounds of the Formula I ii OR -onionlor which comprises reacting 1 mol of a compound of the Formula II HQ-QCm-N wherein R and R have the'abovementioned meaning and R and R independently of one another denote a straight-chain or branched alkyl group or together, and with inclusion of the nitrogen atom, denote a saturated heterocyclic ring, with one mol of a compound of the Formula III wherein R and R have the abovementioned meaning, in the presence of a base selected from alkali amides, alkali hydrides, alkali hydroxides, alkali alcoholates, and alkali compounds of the phosphites of the Formula III.
2. Process according to claim 1, wherein in the Compound I, R and R denote a straight-chain or branched alkyl group or a cycloalkyl group and R and R inde: pendently of one another denote a straight-chain or branched alkyl group, a cycloalkyl group, an alkylthioalkyl group, an alkyloxalkyl group, an alkenyl group, the phenyl group or an alkylphenyl group or together denote the groups -omomor 3. Process according to claim 2, wherein lithium amide is used as the base.
4. Pnocess according to claim 2, wherein the sodium compound of the compound of the Formula III is used as the base.
5. Process according to claim 2, wherein the reaction takes place in the presence of 1 to 30 mol percent of a base.
6. Process according to claim 2, wherein in the com pound of the Formula I, R and R independently of one another denote a straight-chain or branched alkyl group with 1 to 8 carbon atoms or a cycloalkyl group with 6 to 8 carbon atoms and R and R independently of one another denote a straight-chain or branched alkyl group with 1-22 carbon atoms,a cycloalkyl group with 6-8 carbon atoms, the --(CH -Sall yl or (CH 0alkyl groups, wherein the alkyl groups contain 1-18 carbon atoms, the phenyl group or an alkylphenyl group with 7-14 carbon atoms.
7. Process according to claim 2, wherein in the compound of the Formula II, R and R independently of one another denote. alkylwith 1-5 carbon atoms or together and with inclusion of the nitrogen atom form a hydrogenated heterocyclic S-membered or fi-rnembered ring.
8. Process according to claim 6, wherein in the Formula I, R denotes methyl or branched alkyl with 3-4 carbon atoms, R denotes branched alkyl with 3 or 4 carbon atoms and R and R denote straight-chain or branched alkyl groups with 1-18 carbon atoms.
9. Process according to claim 7, wherein in the Formula 11, R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine or morpholine.
10. Process according to claim 7, wherein in the Formula 11, R and R denote methyl, ethyl, propyl or isopropyl or together denote the radical of piperidine.
References Cited 7 UNITED STATES PATENTS I 2,635,112 4/1953 Fields 260-970 ANTON H. SU'ITO, Primary Examiner 7 US. (:1. xn. I 260-451 P, 247.1, 293.9, 948, 950, 953
Applications Claiming Priority (1)
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CH231571A CH542248A (en) | 1971-02-17 | 1971-02-17 | Process for the preparation of benzyl phosphonates |
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US00225615A Expired - Lifetime US3790648A (en) | 1971-02-17 | 1972-02-11 | Process for the manufacture of benzylphosphonates |
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AT (1) | AT309466B (en) |
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CH (1) | CH542248A (en) |
DE (1) | DE2203837C3 (en) |
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962376A (en) * | 1973-09-25 | 1976-06-08 | Ciba-Geigy Corporation | 2,4,6-Trialkyl-3-hydroxyphenylalkane phosphonates and phosphinates |
US3962377A (en) * | 1973-09-25 | 1976-06-08 | Ciba-Geigy Corporation | 2,3,5-Trialkyl-4-hydroxybenzylphosphonates and phosphinates |
US4008199A (en) * | 1975-06-09 | 1977-02-15 | Celanese Corporation | Heat stabilized polyalkylene terephthalate resin composition |
US4093588A (en) * | 1974-10-07 | 1978-06-06 | Ciba-Geigy Corporation | Hindered phenolic cyclic phosphonates and stabilized compositions |
US4210577A (en) * | 1976-12-24 | 1980-07-01 | Argus Chemical Corporation | Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl carboxylic acid ester, phosphonic acid ester and phenol |
US4263232A (en) * | 1979-07-09 | 1981-04-21 | Ciba-Geigy Corporation | Process for the manufacture of selected phosphonates |
US5157141A (en) * | 1989-11-29 | 1992-10-20 | Ciba-Geigy Corporation | Process for the preparation of hydroxybenzylphosphonates |
US5171873A (en) * | 1991-04-05 | 1992-12-15 | Ciba-Geigy Corporation | Process for the preparation of sterically hindered hydroxybenzylphosphonates |
US5258540A (en) * | 1989-11-29 | 1993-11-02 | Ciba-Geigy Corporation | Cyclohexyl substituted hydroxybenyzlphosphonates |
EP0690064A1 (en) | 1994-06-28 | 1996-01-03 | Ciba-Geigy Ag | Process for preparing sterically hindered hydroxybenzylphosphonates |
EP0816354A1 (en) * | 1996-06-25 | 1998-01-07 | Bayer Ag | Process for preparing and stabilisation of aliphatic six-membered cyclic carbonates |
US5756596A (en) * | 1993-12-16 | 1998-05-26 | Ciba Specialty Chemicals Corporation | Increasing the molecular weight of polyamides |
WO2003026632A3 (en) * | 2001-09-26 | 2003-08-21 | Theravance Inc | Substituted phenol compounds useful for anesthesia and sedation |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4128509A1 (en) * | 1991-08-28 | 1993-03-04 | Basf Ag | THERMOXIDATION-RESISTANT THERMOPLASTIC MOLDS |
DE4131951A1 (en) * | 1991-09-25 | 1993-04-08 | Boehme Chem Fab Kg | Use of alkane phosphonic acid and its salt or half ester - as thermostable stabiliser for high temp. treatment of substrates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1917512A1 (en) * | 1969-04-05 | 1970-10-15 | Advance Prod Gmbh | phosphonic acid esters |
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1971
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- 1972-01-27 DE DE2203837A patent/DE2203837C3/en not_active Expired
- 1972-02-11 US US00225615A patent/US3790648A/en not_active Expired - Lifetime
- 1972-02-11 CA CA134496A patent/CA926871A/en not_active Expired
- 1972-02-16 FR FR7205189A patent/FR2125515B1/fr not_active Expired
- 1972-02-16 SU SU1749596A patent/SU509240A3/en active
- 1972-02-16 BE BE779422A patent/BE779422A/en unknown
- 1972-02-16 AT AT124872A patent/AT309466B/en not_active IP Right Cessation
- 1972-02-16 IT IT20636/72A patent/IT950550B/en active
- 1972-02-16 NL NL7202041A patent/NL7202041A/xx unknown
- 1972-02-17 GB GB736672A patent/GB1365622A/en not_active Expired
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962376A (en) * | 1973-09-25 | 1976-06-08 | Ciba-Geigy Corporation | 2,4,6-Trialkyl-3-hydroxyphenylalkane phosphonates and phosphinates |
US3962377A (en) * | 1973-09-25 | 1976-06-08 | Ciba-Geigy Corporation | 2,3,5-Trialkyl-4-hydroxybenzylphosphonates and phosphinates |
US4093588A (en) * | 1974-10-07 | 1978-06-06 | Ciba-Geigy Corporation | Hindered phenolic cyclic phosphonates and stabilized compositions |
US4008199A (en) * | 1975-06-09 | 1977-02-15 | Celanese Corporation | Heat stabilized polyalkylene terephthalate resin composition |
US4210577A (en) * | 1976-12-24 | 1980-07-01 | Argus Chemical Corporation | Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl carboxylic acid ester, phosphonic acid ester and phenol |
US4222931A (en) * | 1976-12-24 | 1980-09-16 | Argus Chemical Corporation | Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl ether alcohol or ether, phosphonic acid ester and phenolic antioxidant |
US4263232A (en) * | 1979-07-09 | 1981-04-21 | Ciba-Geigy Corporation | Process for the manufacture of selected phosphonates |
EP0434606B1 (en) * | 1989-11-29 | 1995-08-16 | Ciba-Geigy Ag | Hydroxybenzylphosphonates and their preparation process |
US5258540A (en) * | 1989-11-29 | 1993-11-02 | Ciba-Geigy Corporation | Cyclohexyl substituted hydroxybenyzlphosphonates |
US5157141A (en) * | 1989-11-29 | 1992-10-20 | Ciba-Geigy Corporation | Process for the preparation of hydroxybenzylphosphonates |
US5171873A (en) * | 1991-04-05 | 1992-12-15 | Ciba-Geigy Corporation | Process for the preparation of sterically hindered hydroxybenzylphosphonates |
US5756596A (en) * | 1993-12-16 | 1998-05-26 | Ciba Specialty Chemicals Corporation | Increasing the molecular weight of polyamides |
EP0690064A1 (en) | 1994-06-28 | 1996-01-03 | Ciba-Geigy Ag | Process for preparing sterically hindered hydroxybenzylphosphonates |
US5618963A (en) * | 1994-06-28 | 1997-04-08 | Ciba-Geigy Corporation | Process for the preparation of sterically hindered hydroxybenzylphosphonates |
EP0816354A1 (en) * | 1996-06-25 | 1998-01-07 | Bayer Ag | Process for preparing and stabilisation of aliphatic six-membered cyclic carbonates |
US5861107A (en) * | 1996-06-25 | 1999-01-19 | Bayer Aktiengesellschaft | Process for the preparation of aliphatic carbonates having a six-membered ring |
WO2003026632A3 (en) * | 2001-09-26 | 2003-08-21 | Theravance Inc | Substituted phenol compounds useful for anesthesia and sedation |
US6815555B2 (en) | 2001-09-26 | 2004-11-09 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
US20050032753A1 (en) * | 2001-09-26 | 2005-02-10 | Jenkins Thomas E. | Substituted phenol compounds useful for anesthesia and sedation |
US7226946B2 (en) | 2001-09-26 | 2007-06-05 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
Also Published As
Publication number | Publication date |
---|---|
SU509240A3 (en) | 1976-03-30 |
NL7202041A (en) | 1972-08-21 |
CA926871A (en) | 1973-05-22 |
IT950550B (en) | 1973-06-20 |
AT309466B (en) | 1973-08-27 |
DE2203837A1 (en) | 1972-08-31 |
DE2203837C3 (en) | 1981-07-23 |
BE779422A (en) | 1972-08-16 |
FR2125515A1 (en) | 1972-09-29 |
FR2125515B1 (en) | 1974-09-13 |
DE2203837B2 (en) | 1980-06-26 |
CH542248A (en) | 1973-09-30 |
GB1365622A (en) | 1974-09-04 |
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