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Publication numberUS3687135 A
Publication typeGrant
Publication date29 Aug 1972
Filing date15 Sep 1969
Priority date20 Aug 1969
Also published asDE1953241A1, DE1953241B2
Publication numberUS 3687135 A, US 3687135A, US-A-3687135, US3687135 A, US3687135A
InventorsVladislav Sergeevich Borodkin, Evgeny Mikhailovich Savitsky, Konstantin Mitrofanovic Sivash, Genrikh Borisovich Stroganov, Vera Fedorovna Terekhova, Nina Mikhailovna Tikhova, Mstislav Vasilievich Volkov
Original AssigneeEvgeny Mikhailovich Savitsky, Genrikh Borisovich Stroganov, Konstantin Mitrofanovich Sivas, Mstislav Vasilievich Volkov, Nina Mikhailovna Tikhova, Vera Fedorovna Terekhova, Vladislav Sergeevich Borodkin
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Magnesium-base alloy for use in bone surgery
US 3687135 A
Abstract
A magnesium-base alloy for use in bone surgery which contains the following components, wt.%:
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waited States Patent Stroganov et a1.

[54] MAGNESIUM-BASE ALLOY FOR USE IN BONE SURGERY [72] Inventors: Genrikh Borisovich Stroganov, 2

Voikovsky proezd, 1, kv. 29; Evgeny Mikhailovich Savitsky, ulitsa Dmitria Ulyanova, 3, kv. 13; Nina Mikhailovna Tikhova, Frunzenskaya naberezhnaya, 38/1, kv. 394; Vera Fedorovna Terekhova, Belyaevo- Bogorodskoe, kvartal 48, korpus 23, kv. 235; Mstislav Vasilievich Volkov, 1 Stroitelnaya ulitsa, 6, korpus 5, kv. 10; Konstantin Mitrofanovich Sivash, B. Pirogovskaya ulitsa,

37/43 A, kv. 49; Vladislav Sergeevich Borodkin, Shelepikha, 5 ulitsa, 6/8, kv. 91, all of, Moscow, USSR.

[22] Filed: Sept. 15, 1969 [21] Appl. No.: 858,149

[52] US. Cl. ..128/92 B, 75/168 R, 75/168 M, 75/168 .1, 128/92 BA, 128/92 BB, 128/92 BC, 128/92 C [51] Int. Cl. ..C22c 23/00, A61f 5/01 [58] Field of Search..75/l68; 128/92 R, 92 B, 92 BB, 128/92 BA, 92 BC, 92 C, 92 CA, 92 D; 3/1

[ 51 Aug. 29, 1972 2,221,319 11/1940 Altwicker et a] ..75/168 B 2,549,955 4/1951 Jessup et a]. ..75/168 J OTHER PUBLICATIONS Annals of Surgery, Vol. 105, No. 6, June 1937, pp. 919, 920 & 938.

Primary ExaminerCharles N. Lovell Att0rneyWaters, Roditi, Schwartz & Nissen [57] ABSTRACT A magnesium-base alloy for use in bone surgery which contains the following components, wt.%:

Rare earth element 0.4-4.0 Cadmium 005-1 .2 An element from the group consisting of calcium and aluminum 0.05-1 .0 Manganese 0.05-.05 Silver 0-0.8 Zirconium 0-0.8 Silicon 0-0.3 Magnesium remainder 5 Claims, N0 Drawings MAGNES-BASE ALLOY FOR USE IN BONE SURGERY The present invention relates to magnesium-base alloys employed as a joining and fixation material in bone surgery.

One of the main problems in the operative treatment of bone fractures is finding a material for fixation means which is sufficiently strong, is absorbed after the completion of union and stimulates callus formation. The search for such a material has been made predominantly among organic substances although there are isolated reports of the study and use of inorganic materials, particularly metals.

Magnesium was first employed for osteosynthesis by Lambotte in 1907. In fracture of the bones of the lower leg a magnesium plate secured with gold-plate steel nails was used, but in 8 days the plate disintegrated with the formation of a large amount of gas under the skin. In spite of Lambottes failure, study of the effect of magnesium on the surrounding tissue and the body as a whole continued.

An attempt to use pure magnesium for osteosynthesis was unsuccessful because magnesium pins disintegrated so quickly that they were unsuitable for the fixation of bone fragments; nevertheless, clinical, X-ray and histological investigations demonstrated that pure magnesium introduced into the body in the form of a pin has no harmful effect.

Attempts were made to dust bone transplants with magnesium and calcium in vacuum and then graft them in the patients body. It was found that magnesium and calcium promoted rapid restoration of the entirety of the bone, this taking place 3 months sooner than when an untreated autotransplant was employed. Said method, however, is laborious and requires drainage for drawing off the gas formed.

Magnesium alloys with other metals have also been tried. Verbrugge used an alloy consisting of 92 percent magnesium and 8 percent aluminum; E. Bride reported the use of an alloy consisting of 95 percent magnesium, 4.7 percent aluminum and 0.3 percent manganese; M.S. Znamensky used an alloy consisting of 97.3 percent magnesium, 2.5 percent aluminum and 0.2 percent beryllium; B.I. Klepatsky tried an alloy consisting of 82.8 percent magnesium, 85 percent aluminum, 8.5 percent zinc and 0.2 percent manganese.

A review of the literature indicates that magnesium alloys employed for making fixation means dissolve completely in the bone and have no detrimental effect either locally or generally. However, the absorption of previously known magnesium alloys proceeds three or four times more rapidly than required from the standpoint of restoration of the entirety of the bone. Moreover, when said known alloys are used, drainage is necessary to remove the gas formed.

It is an object of the present invention to provide a magnesium-base alloy which has a rate of absorption slower than the process of bone consolidation, which does not involve vigorous evolution of gas and which has high mechanical strength.

It is another object of the invention to provide a magnesium-base alloy which meets the following requirements:

1. Ultimate strength a 28 kg/mm and yield point 2 18 kg/mm, i.e., the alloys mechanical strength shall exceed that of bone tissue;

2. The rate of absorption of the alloy compared to the rate of consolidation of the bone shall be such that at the moment of complete restoration of the bones entirety the alloy shall retain sufficient strength, i.e., the process of absorption shall be completed 1.5-2 months after knitting of the bone;

3. The rate of evolution of hydrogen during absorption of the alloy in the body shall be less or equal to the rate of absorption of hydrogen by the body.

4. The alloy shall contain elements which stimulate the growth of bone tissue, such as calcium and cadmium;

5. The alloy shall not contain elements which are harmful for the living organism, such as lead, beryllium, copper, thorium, zinc, nickel, etc.

The foregoing objects have been accomplished by the provision of a magnesium-base alloy which, accord ing to the invention, contains the following elements,

Rare earth metal 0.40-4.0 Cadmium 005-1 .2 Calcium or aluminum 0.05-1 .0 Manganese 0.05-1.0 Silver 00.8 Zirconium 0-O.8 Silicon 00.3 Magnesium remainder Neodymium and yttrium are predominantly employed as the rare earth metal although other rare earth metals can be used.

The above alloy is produced by the conventional method by preparing a charge consisting of pure metals and master alloys and melting the same.

One of the advantages of the invention is that it provides an alloy having high chemico-physiological, mechanical and engineering properties. The ultimate strength of said alloy e 28 kg/mm and the yield point a 18 kglmm Employment of said alloy for joining bone fragments obviates the necessity of a second operation on the patient for the removal of foreign fastening means (pins, nails, etc.) since said alloy is completely absorbed without the accumulation of gas. Moreover, the stimulation of callus formation promotes the pateients rapid recovery.

The following examples of variations in the composition of the alloy according to the invention are given by way of illustration.

EXAMPLE 1 Illustrates an alloy of the following composition, wt.%:

Neodymium 2.92 Cadmium 0.27 Calcium 0.24 Manganese 0.1 1 Magnesium remainder The above alloy has the following properties:

Ultimate strength 32.6 kg/mm Yield point 24.5 kg/mm Elongation 6.3%

Said alloy was tested in a physiological solution containing 0.9 wt.% NaCl, 0.02 wt.% KCl, 0.02 wt.% CaCl 0.002 wt.% Na CO and the remainder, distilled water. Evolution of hydrogen in 48 hours totalled 3.4 cm /cm The result of the test indirectly gives a conception of the process of absorption of the metal in the body.

EXAMPLE 2 Illustrates an alloy of the following composition, wt.%:

Neodymium 2.46 Cadmium 0. l 2 Aluminum 0.09 Manganese 0. l 4 Silicon 0.01 Magnesium remainder The above alloy has the following properties:

Ultimate strength 31.6 lrg/mm Yield point 25.3 ltg/mm" Elongation 3.7% Hydrogen evolution in physiological solution of Example I, 48 hrs. 2.1 em /cm EXAMPLE 3 Illustrates an alloy of the following composition, wt.%

Yttrium 1.6 Cadmium 0.25 Calcium 0.06

Silver 0.3 Manganese 0.08 Magnesium remainder The above alloy has the following properties:

Ultimate strength 28.4 kg/nim Yield point 23.6 kg/mm Elongation 5.5% Hydrogen evolution in physiological solution of Example 1, 48 hrs. [.6 cmVcrn EXAMPLE 4 Illustrates an alloy of the following composition, wt.%:

Neodymium Cadmium Calcium 0.08 Manganese 0.13 Zirconium 0.49 Magnesium remainder The above alloy has the following properties:

Ultimate strength 32.2 kglmm Yield point 21.8 kg/mrn Elongation 8.9% Hydrogen evolution in physiological solution of Example I, 48 hrs. 2.0 cm lcm MgCl, 34-40 KC] 25-36 NaCl CaCl s 8.0

CaF, -20

MgO 7-10 After melting and thoroughly mixing, the alloy was refined with the above flux and let stand for 15-20 minutes, after which it was poured at a temperature of 760-780C through a magnesite filter into moulds.

After preheating and hot pressing at 520-540C the blanks were cooled in the air after which they were artificially aged at 16021 0C for 16 hours.

The alloys thus produced were ready for use. Employment of the alloys specified in Examples 1, 2, 3 and 4 for joining bones in bone surgery demonstrated that all of said alloys possessed high mechanical and chemico-physiological properties. Clinical tests showed that said alloys were completely absorbed: pins 3 mm in diameter in 5 months and pins 8 mm in diameter in l 1 months. Bones knitted in 4 months.

F luoroscopic examination revealed no gas bubbles in the soft tissues during the entire period of absorption of said alloys.

Operative treatment of fractures by means of the I present alloy reduces the time required for union of the bone by 33-50 percent. In this respect the best showing was made by the alloy described in Example 2.

As is apparent from the figures cited, evolution of gas by the alloys described in Examples 1, 2, 3 and 4 is within the bodys absorptive capacity, since said capacity is 4.0-4.5 cm of gas from each sq.cm. of surface of the metal being absorbed per 48 hrs.

We claim:

1. A bone fastening device, for the fixation of bone fragments, constructed of an alloy, consisting essen tially of, by wt.%:

Rare earth element 0.4-4.0 Cadmium 0.05-2.22 An element selected from the group consisting of calcium and aluminum (-1 .0 Manganese ODS-0.5 Silver 00.8 Zirconium 0-0.8 Silicon O-0.3 Magnesium remainder 2. A device as in claim I which has the following composition by wt.%:

Neodymium 2.92 Cadmium 0.27 Calcium 0.24 Manganese 0.! 1 Magnesium remainder 3. A device as in claim 1 which has the following composition, by wt.%:

Neodymium 2.46 Cadmium 0. l 2 Aluminum 0.09 Manganese 0.14 Silicon 0.01 Magnesium remainder 4. A device as in claim 1 which has the following compositions, wt.%:

Yttrium L6 Cadmium 0.25 Calcium 0.06 Silver 0.3 Manganese 0.08 Magnesium remainder composition, wt.%:

Neodymium Cadmium Calcium Manganese Zirconium Magnesium remainder

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2094578 *1 Sep 19335 Oct 1937Bernhard BlumenthalMaterial for surgical ligatures and sutures
US2221319 *22 Oct 193812 Nov 1940Magnesium Dev CorpMagnesium base alloy
US2270194 *23 Dec 194013 Jan 1942Dow Chemical CoMagnesium base alloy
US2286866 *23 Dec 194016 Jun 1942Dow Chemical CoMagnesium base alloy
US2549955 *4 Jan 194924 Apr 1951Magnesium Elektron LtdMagnesium base alloys
Non-Patent Citations
Reference
1 *Annals of Surgery, Vol. 105, No. 6, June 1937, pp. 919, 920 & 938.
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Citing PatentFiling datePublication dateApplicantTitle
US4269721 *21 Dec 197926 May 1981Stauffer Chemical CompanyDust abatement with calcium sulfate
US6767506 *14 Mar 200227 Jul 2004Dead Sea Magnesium Ltd.High temperature resistant magnesium alloys
US7048812 *20 Jun 200323 May 2006Cast Centre Pty LtdCreep resistant magnesium alloy
US707786024 Jun 200418 Jul 2006Advanced Cardiovascular Systems, Inc.Method of reducing or eliminating thrombus formation
US719867530 Sep 20033 Apr 2007Advanced Cardiovascular SystemsStent mandrel fixture and method for selectively coating surfaces of a stent
US722947110 Sep 200412 Jun 2007Advanced Cardiovascular Systems, Inc.Compositions containing fast-leaching plasticizers for improved performance of medical devices
US72588917 Apr 200321 Aug 2007Advanced Cardiovascular Systems, Inc.Stent mounting assembly and a method of using the same to coat a stent
US728530425 Jun 200323 Oct 2007Advanced Cardiovascular Systems, Inc.Fluid treatment of a polymeric coating on an implantable medical device
US729116618 May 20056 Nov 2007Advanced Cardiovascular Systems, Inc.Polymeric stent patterns
US729715921 Jul 200420 Nov 2007Advanced Cardiovascular Systems, Inc.Selective coating of medical devices
US72977582 Aug 200520 Nov 2007Advanced Cardiovascular Systems, Inc.Method for extending shelf-life of constructs of semi-crystallizable polymers
US732936618 Jun 200412 Feb 2008Advanced Cardiovascular Systems Inc.Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
US738104812 Apr 20053 Jun 2008Advanced Cardiovascular Systems, Inc.Stents with profiles for gripping a balloon catheter and molds for fabricating stents
US747624516 Aug 200513 Jan 2009Advanced Cardiovascular Systems, Inc.Polymeric stent patterns
US755337727 Apr 200430 Jun 2009Advanced Cardiovascular Systems, Inc.Apparatus and method for electrostatic coating of an abluminal stent surface
US756332429 Dec 200321 Jul 2009Advanced Cardiovascular Systems Inc.System and method for coating an implantable medical device
US760470016 Jan 200720 Oct 2009Advanced Cardiovascular Systems, Inc.Stent mandrel fixture and method for selectively coating surfaces of a stent
US762207020 Jun 200524 Nov 2009Advanced Cardiovascular Systems, Inc.Method of manufacturing an implantable polymeric medical device
US763230716 Dec 200415 Dec 2009Advanced Cardiovascular Systems, Inc.Abluminal, multilayer coating constructs for drug-delivery stents
US765888029 Jul 20059 Feb 2010Advanced Cardiovascular Systems, Inc.Polymeric stent polishing method and apparatus
US766232627 Apr 200716 Feb 2010Advanced Cardiovascular Systems, Inc.Compositions containing fast-leaching plasticizers for improved performance of medical devices
US769989028 Jan 200420 Apr 2010Advanced Cardiovascular Systems, Inc.Medicated porous metal prosthesis and a method of making the same
US770854810 Apr 20084 May 2010Advanced Cardiovascular Systems, Inc.Molds for fabricating stents with profiles for gripping a balloon catheter
US773189015 Jun 20068 Jun 2010Advanced Cardiovascular Systems, Inc.Methods of fabricating stents with enhanced fracture toughness
US774079130 Jun 200622 Jun 2010Advanced Cardiovascular Systems, Inc.Method of fabricating a stent with features by blow molding
US775754313 Jul 200620 Jul 2010Advanced Cardiovascular Systems, Inc.Radio frequency identification monitoring of stents
US775888124 Mar 200520 Jul 2010Advanced Cardiovascular Systems, Inc.Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US776196825 May 200627 Jul 2010Advanced Cardiovascular Systems, Inc.Method of crimping a polymeric stent
US779449517 Jul 200614 Sep 2010Advanced Cardiovascular Systems, Inc.Controlled degradation of stents
US779477629 Jun 200614 Sep 2010Abbott Cardiovascular Systems Inc.Modification of polymer stents with radiation
US78232639 Jul 20072 Nov 2010Abbott Cardiovascular Systems Inc.Method of removing stent islands from a stent
US782900830 May 20079 Nov 2010Abbott Cardiovascular Systems Inc.Fabricating a stent from a blow molded tube
US784273729 Sep 200630 Nov 2010Abbott Cardiovascular Systems Inc.Polymer blend-bioceramic composite implantable medical devices
US786754719 Dec 200511 Jan 2011Advanced Cardiovascular Systems, Inc.Selectively coating luminal surfaces of stents
US787523318 Jul 200525 Jan 2011Advanced Cardiovascular Systems, Inc.Method of fabricating a biaxially oriented implantable medical device
US7879367 *17 Jul 19981 Feb 2011Alfons FischerMetallic implant which is degradable in vivo
US788641918 Jul 200615 Feb 2011Advanced Cardiovascular Systems, Inc.Stent crimping apparatus and method
US790145227 Jun 20078 Mar 2011Abbott Cardiovascular Systems Inc.Method to fabricate a stent having selected morphology to reduce restenosis
US790590216 Jun 200315 Mar 2011Ethicon Endo-Surgery, Inc.Surgical implant with preferential corrosion zone
US792302213 Sep 200612 Apr 2011Advanced Cardiovascular Systems, Inc.Degradable polymeric implantable medical devices with continuous phase and discrete phase
US79511856 Jan 200631 May 2011Advanced Cardiovascular Systems, Inc.Delivery of a stent at an elevated temperature
US795119422 May 200731 May 2011Abbott Cardiovascular Sysetms Inc.Bioabsorbable stent with radiopaque coating
US795538129 Jun 20077 Jun 2011Advanced Cardiovascular Systems, Inc.Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
US795538214 Sep 20077 Jun 2011Boston Scientific Scimed, Inc.Endoprosthesis with adjustable surface features
US79598571 Jun 200714 Jun 2011Abbott Cardiovascular Systems Inc.Radiation sterilization of medical devices
US795994030 May 200614 Jun 2011Advanced Cardiovascular Systems, Inc.Polymer-bioceramic composite implantable medical devices
US796421031 Mar 200621 Jun 2011Abbott Cardiovascular Systems Inc.Degradable polymeric implantable medical devices with a continuous phase and discrete phase
US79679983 Jan 200828 Jun 2011Advanced Cardiocasvular Systems, Inc.Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
US797133330 May 20065 Jul 2011Advanced Cardiovascular Systems, Inc.Manufacturing process for polymetric stents
US798525230 Jul 200826 Jul 2011Boston Scientific Scimed, Inc.Bioerodible endoprosthesis
US798901831 Mar 20062 Aug 2011Advanced Cardiovascular Systems, Inc.Fluid treatment of a polymeric coating on an implantable medical device
US79981929 May 200816 Aug 2011Boston Scientific Scimed, Inc.Endoprostheses
US799840413 Jul 200616 Aug 2011Advanced Cardiovascular Systems, Inc.Reduced temperature sterilization of stents
US800282113 Sep 200723 Aug 2011Boston Scientific Scimed, Inc.Bioerodible metallic ENDOPROSTHESES
US80031564 May 200623 Aug 2011Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US80075291 Aug 200830 Aug 2011Advanced Cardiovascular Systems, Inc.Medicated porous metal prosthesis
US801687927 Jun 200713 Sep 2011Abbott Cardiovascular Systems Inc.Drug delivery after biodegradation of the stent scaffolding
US801723723 Jun 200613 Sep 2011Abbott Cardiovascular Systems, Inc.Nanoshells on polymers
US803428715 May 200711 Oct 2011Abbott Cardiovascular Systems Inc.Radiation sterilization of medical devices
US804355330 Sep 200425 Oct 2011Advanced Cardiovascular Systems, Inc.Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US804815012 Apr 20061 Nov 2011Boston Scientific Scimed, Inc.Endoprosthesis having a fiber meshwork disposed thereon
US804844125 Jun 20071 Nov 2011Abbott Cardiovascular Systems, Inc.Nanobead releasing medical devices
US804844815 Jun 20061 Nov 2011Abbott Cardiovascular Systems Inc.Nanoshells for drug delivery
US80527432 Aug 20078 Nov 2011Boston Scientific Scimed, Inc.Endoprosthesis with three-dimensional disintegration control
US805274413 Sep 20078 Nov 2011Boston Scientific Scimed, Inc.Medical devices and methods of making the same
US805274513 Sep 20078 Nov 2011Boston Scientific Scimed, Inc.Endoprosthesis
US805753414 Sep 200715 Nov 2011Boston Scientific Scimed, Inc.Bioerodible endoprostheses and methods of making the same
US808005527 Dec 200720 Dec 2011Boston Scientific Scimed, Inc.Bioerodible endoprostheses and methods of making the same
US80890291 Feb 20063 Jan 2012Boston Scientific Scimed, Inc.Bioabsorbable metal medical device and method of manufacture
US809984913 Dec 200624 Jan 2012Abbott Cardiovascular Systems Inc.Optimizing fracture toughness of polymeric stent
US811885729 Nov 200721 Feb 2012Boston Scientific CorporationMedical articles that stimulate endothelial cell migration
US812868819 Jun 20076 Mar 2012Abbott Cardiovascular Systems Inc.Carbon coating on an implantable device
US812868914 Sep 20076 Mar 2012Boston Scientific Scimed, Inc.Bioerodible endoprosthesis with biostable inorganic layers
US817289728 Jun 20048 May 2012Advanced Cardiovascular Systems, Inc.Polymer and metal composite implantable medical devices
US817290823 Dec 20088 May 2012The University Of Hong KongImplant for tissue engineering
US817306230 Sep 20048 May 2012Advanced Cardiovascular Systems, Inc.Controlled deformation of a polymer tube in fabricating a medical article
US819787916 Jan 200712 Jun 2012Advanced Cardiovascular Systems, Inc.Method for selectively coating surfaces of a stent
US82025285 Jun 200719 Jun 2012Abbott Cardiovascular Systems Inc.Implantable medical devices with elastomeric block copolymer coatings
US823604610 Jun 20087 Aug 2012Boston Scientific Scimed, Inc.Bioerodible endoprosthesis
US824155429 Jun 200414 Aug 2012Advanced Cardiovascular Systems, Inc.Method of forming a stent pattern on a tube
US82627239 Apr 200711 Sep 2012Abbott Cardiovascular Systems Inc.Implantable medical devices fabricated from polymer blends with star-block copolymers
US82679922 Mar 201018 Sep 2012Boston Scientific Scimed, Inc.Self-buffering medical implants
US82932605 Jun 200723 Oct 2012Abbott Cardiovascular Systems Inc.Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US829336715 Jul 201123 Oct 2012Advanced Cardiovascular Systems, Inc.Nanoshells on polymers
US830364321 May 20106 Nov 2012Remon Medical Technologies Ltd.Method and device for electrochemical formation of therapeutic species in vivo
US833300019 Jun 200618 Dec 2012Advanced Cardiovascular Systems, Inc.Methods for improving stent retention on a balloon catheter
US834353022 Dec 20061 Jan 2013Abbott Cardiovascular Systems Inc.Polymer-and polymer blend-bioceramic composite implantable medical devices
US83828243 Oct 200826 Feb 2013Boston Scientific Scimed, Inc.Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US83986807 Apr 201019 Mar 2013Lsi Solutions, Inc.Bioabsorbable magnesium knots for securing surgical suture
US842559111 Jun 200723 Apr 2013Abbott Cardiovascular Systems Inc.Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US842583511 Nov 200323 Apr 2013Biotronik Vi Patent AgEndoprosthesis
US843528110 Apr 20097 May 2013Boston Scientific Scimed, Inc.Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys
US843555013 Aug 20087 May 2013Abbot Cardiovascular Systems Inc.Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US846578918 Jul 201118 Jun 2013Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US847001414 Aug 200725 Jun 2013Advanced Cardiovascular Systems, Inc.Stent-catheter assembly with a releasable connection for stent retention
US84861359 Apr 200716 Jul 2013Abbott Cardiovascular Systems Inc.Implantable medical devices fabricated from branched polymers
US853537218 Jun 200717 Sep 2013Abbott Cardiovascular Systems Inc.Bioabsorbable stent with prohealing layer
US856846928 Jun 200429 Oct 2013Advanced Cardiovascular Systems, Inc.Stent locking element and a method of securing a stent on a delivery system
US859203620 Sep 201226 Nov 2013Abbott Cardiovascular Systems Inc.Nanoshells on polymers
US859621518 Jul 20113 Dec 2013Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US860353014 Jun 200610 Dec 2013Abbott Cardiovascular Systems Inc.Nanoshell therapy
US863711018 Jul 201128 Jan 2014Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US866340121 Nov 20114 Mar 2014Schlumberger Technology CorporationDegradable compositions, apparatus comprising same, and methods of use
US866873222 Mar 201111 Mar 2014Boston Scientific Scimed, Inc.Surface treated bioerodible metal endoprostheses
US871533921 Nov 20116 May 2014Boston Scientific Scimed, Inc.Bioerodible endoprostheses and methods of making the same
US874137918 Jul 20113 Jun 2014Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US874787828 Apr 200610 Jun 2014Advanced Cardiovascular Systems, Inc.Method of fabricating an implantable medical device by controlling crystalline structure
US874787931 May 200610 Jun 2014Advanced Cardiovascular Systems, Inc.Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US87522679 Aug 201317 Jun 2014Abbott Cardiovascular Systems Inc.Method of making stents with radiopaque markers
US87522689 Aug 201317 Jun 2014Abbott Cardiovascular Systems Inc.Method of making stents with radiopaque markers
US877825630 Sep 200415 Jul 2014Advanced Cardiovascular Systems, Inc.Deformation of a polymer tube in the fabrication of a medical article
US880834223 Apr 201319 Aug 2014Abbott Cardiovascular Systems Inc.Nanoshell therapy
US880872614 Sep 200719 Aug 2014Boston Scientific Scimed. Inc.Bioerodible endoprostheses and methods of making the same
US88406605 Jan 200623 Sep 2014Boston Scientific Scimed, Inc.Bioerodible endoprostheses and methods of making the same
US88407367 Sep 200523 Sep 2014Biotronik Vi Patent AgEndoprosthesis comprising a magnesium alloy
US8888842 *21 Jun 201018 Nov 2014Qualimed Innovative Medizin-Produkte GmbhImplant made of a metallic material which can be resorbed by the body
US892517717 Jul 20126 Jan 2015Abbott Cardiovascular Systems Inc.Methods for improving stent retention on a balloon catheter
US90382608 May 201426 May 2015Abbott Cardiovascular Systems Inc.Stent with radiopaque markers
US90728106 Mar 20127 Jul 2015The University Of Hong KongImplant for tissue engineering
US907282026 Jun 20067 Jul 2015Advanced Cardiovascular Systems, Inc.Polymer composite stent with polymer particles
US911990624 Sep 20081 Sep 2015Integran Technologies, Inc.In-vivo biodegradable medical implant
US9155816 *10 Dec 201213 Oct 2015National Institute For Materials ScienceMagnesium-based medical device and manufacturing method thereof
US917373321 Aug 20063 Nov 2015Abbott Cardiovascular Systems Inc.Tracheobronchial implantable medical device and methods of use
US91987854 Dec 20131 Dec 2015Abbott Cardiovascular Systems Inc.Crush recoverable polymer scaffolds
US924803423 Aug 20052 Feb 2016Advanced Cardiovascular Systems, Inc.Controlled disintegrating implantable medical devices
US925934127 Feb 201316 Feb 2016Abbott Cardiovascular Systems Inc.Methods for improving stent retention on a balloon catheter
US928309925 Aug 200415 Mar 2016Advanced Cardiovascular Systems, Inc.Stent-catheter assembly with a releasable connection for stent retention
US929557023 Feb 200529 Mar 2016Abbott Laboratories Vascular Enterprises LimitedCold-molding process for loading a stent onto a stent delivery system
US935832522 Apr 20157 Jun 2016Abbott Cardiovascular Systems Inc.Stents with radiopaque markers
US946870431 Oct 201218 Oct 2016Biotronik Vi Patent AgImplant made of a biodegradable magnesium alloy
US953288831 Dec 20143 Jan 2017Abbott Cardiovascular Systems Inc.Stents with radiopaque markers
US957922524 Nov 201428 Feb 2017Abbott Cardiovascular Systems Inc.Methods for improving stent retention on a balloon catheter
US969411610 May 20164 Jul 2017Abbott Cardiovascular Systems Inc.Stents with radiopaque markers
US970065218 Jan 200611 Jul 2017Biotronik Vi Patent AgAbsorbable medical implant made of fiber-reinforced magnesium or fiber-reinforced magnesium alloys
US20020004060 *17 Jul 199810 Jan 2002Bernd HeubleinMetallic implant which is degradable in vivo
US20040098108 *11 Nov 200320 May 2004Biotronik Gmbh & Co. KgEndoprosthesis
US20040241036 *11 Jun 20022 Dec 2004Andrea Meyer-LindenbergMedical implant for the human or animal body
US20040254608 *16 Jun 200316 Dec 2004Huitema Thomas W.Surgical implant with preferential corrosion zone
US20050002821 *20 Jun 20036 Jan 2005Bettles Colleen JoyceCreep resistant magnesium alloy
US20050079088 *13 Dec 200214 Apr 2005Carl-Joachim WirthMedical implants, prostheses, prosthesis parts, medical instruments, devices and auxiliary contrivances made of a halogenide-modified magnesium substance
US20050266041 *24 May 20051 Dec 2005Restate Patent AgImplant for vessel ligature
US20060020289 *22 Jul 200526 Jan 2006Biotronik Vi Patent AgBiocompatible and bioabsorbable suture and clip material for surgical purposes
US20060052863 *7 Sep 20059 Mar 2006Biotronik Vi Patent AgEndoprosthesis comprising a magnesium alloy
US20060052864 *7 Sep 20059 Mar 2006Biotronik Vi Patent AgEndoprosthesis comprising a magnesium alloy
US20060246107 *11 Oct 20032 Nov 2006Claus HarderUse of one or more elements from the group containing yttrium, neodymium and zirconium and pharmaceutical compositions containing said elements
US20060271170 *31 May 200530 Nov 2006Gale David CStent with flexible sections in high strain regions
US20060292690 *21 Jun 200628 Dec 2006Cesco Bioengineering Co., Ltd.Method of making cell growth surface
US20070025848 *29 Jul 20051 Feb 2007Shawcross James PReduced noise diffuser for a motor-fan assembly
US20070280851 *15 May 20076 Dec 2007Abigail FreemanRadiation sterilization of medical devices
US20080071349 *13 Sep 200720 Mar 2008Boston Scientific Scimed, Inc.Medical Devices
US20080086201 *14 Sep 200710 Apr 2008Boston Scientific Scimed, Inc.Magnetized bioerodible endoprosthesis
US20080140199 *16 Jul 200512 Jun 2008Arne BriestImpantable Body for Spinal Fusion
US20080200950 *16 Aug 200521 Aug 2008Stephen WohlertSurgical Hook
US20090143856 *29 Nov 20074 Jun 2009Boston Scientific CorporationMedical articles that stimulate endothelial cell migration
US20090187258 *23 Dec 200823 Jul 2009Wing Yuk IpImplant for Tissue Engineering
US20090287301 *16 May 200819 Nov 2009Boston Scientific, Scimed Inc.Coating for medical implants
US20090306725 *16 Nov 200710 Dec 2009Sachiko HiromotoMagnesium-based medical device and manufacturing method thereof
US20100034899 *8 Oct 200911 Feb 2010Biotronik Vi Patent AgUse of one or more of the elements from the group yttrium, neodymium and zirconium, and pharmaceutical compositions which contain those elements
US20100075162 *21 Sep 200725 Mar 2010Seok-Jo YangImplants comprising biodegradable metals and method for manufacturing the same
US20100119576 *8 Oct 200913 May 2010Biotronik Vi Patent AgUse of one or more of the elements from the group yttrium, neodymium and zirconium, and pharmaceutical compositions which contain those elements
US20110172724 *14 Dec 200614 Jul 2011Gkss-Forschungszentrum Geesthacht GmbhBiocompatible magnesium material
US20110313527 *11 Aug 200922 Dec 2011Aap Biomaterials GmbhImplant made of a magnesium alloy and method for the production thereof
US20120143318 *21 Jun 20107 Jun 2012Manfred GulcherImplant made of a metallic material which can be resorbed by the body
US20130041455 *23 Mar 201114 Feb 2013Bodo GeroldImplant made of a biodegradable magnesium alloy
US20130129908 *10 Dec 201223 May 2013National Institute For Materials ScienceMagnesium-based medical device and manufacturing method thereof
CN103993187A *21 May 201420 Aug 2014太原理工大学Preparation method of medical degradable magnesium-bismuth alloy plate
CN104911427A *19 Jun 201516 Sep 2015北京大学Mg-Ca-Sr-Zn magnesium alloy as well as preparation method and application thereof
CN104911427B *19 Jun 201530 Jun 2017北京大学一种Mg‑Ca‑Sr‑Zn系镁合金及其制备方法与应用
DE10128100A1 *11 Jun 200119 Dec 2002Hannover Med HochschuleMedical implant used for humans and animals is made from magnesium alloy containing additions of rare earth metals and lithium
DE10163106A1 *24 Dec 200110 Jul 2003Univ HannoverMedizinische Implantate, Prothesen, Protheseteile, medizinische Instrumente, Geräte und Hilfsmittel aus einem halogenid-modifizierten Magnesiumwerkstoff
DE10253634A1 *13 Nov 200227 May 2004Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro BerlinEndoprothese
DE10361941A1 *24 Dec 200328 Jul 2005Restate Patent AgCoating for the outer surface of a medical implant, especially a stent or electrode, comprises magnesium, a magnesium alloy or a magnesium salt
DE102004026104A1 *25 May 200415 Dec 2005Restate Patent AgImplantat zur Gefäßligatur
DE102004043231A1 *7 Sep 20049 Mar 2006Biotronik Vi Patent AgEndoprothese aus einer Magnesiumlegierung
DE102004043232A1 *7 Sep 20049 Mar 2006Biotronik Vi Patent AgEndoprothese aus einer Magnesiumlegierung
DE102005003188A1 *20 Jan 200527 Jul 2006Restate Patent AgMedizinisches Implantat aus einer amorphen oder nanokristallinen Legierung
DE102010019365A15 May 201022 Jun 2011Acoredis GmbH, 07743Bioabsorbable occlusion device, which is introduced by a catheter in a folded condition in a patient's body, where the device in an area of its surrounding envelope comes to a constriction, useful to treat e.g. atrial septal defects
EP0966979A2 *11 Jun 199929 Dec 1999BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro BerlinImplantable bioresorbable support for the vascular walls, in particular coronary stent
EP0966979A3 *11 Jun 199927 Dec 2000BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro BerlinImplantable bioresorbable support for the vascular walls, in particular coronary stent
EP1270023A3 *17 Jul 199817 Dec 2003Meyer, JörgMetallic implant which is degradable in vivo
EP1419793A1 *17 Oct 200319 May 2004Biotronik GmbH & Co. KGEndoprosthesis with a supporting structure of magnesium alloy
EP1552856A117 Jul 199813 Jul 2005Meyer, JörgMetallic implant which is degradable in vivo
EP1618901A1 *22 Jun 200525 Jan 2006Biotronik VI Patent AGBiokompatible and biodegradable suture and staple material for surgical use
EP1959025A1 *16 Nov 200620 Aug 2008National Institute for Materials ScienceMagnesium-based biodegradable metal material
EP1959025A4 *16 Nov 200630 Jun 2010Nat Inst For Materials ScienceMagnesium-based biodegradable metal material
WO1999003515A2 *17 Jul 199828 Jan 1999Meyer, JörgMetallic implant which is degradable in vivo
WO1999003515A3 *17 Jul 19985 Aug 1999Meyer JoergMetallic implant which is degradable in vivo
WO2006008104A1 *16 Jul 200526 Jan 2006Ossacur AgImplantable body for spinal fusion
WO2010034098A118 Feb 20091 Apr 2010Integran Technologies, Inc.In-vivo biodegradable medical implant
Classifications
U.S. Classification606/76, 420/410
International ClassificationC22C25/00, A61B17/58, C22C23/06, C22C23/00, C22C24/00, A61L31/02, A61B17/00, A61L31/14, A61F2/00
Cooperative ClassificationA61F2310/00041, A61B2017/00004, C22C24/00, C22C23/06, A61L31/022, A61L2430/02, C22C23/00, C22C25/00, A61B17/58, A61L31/148
European ClassificationC22C25/00, C22C24/00, C22C23/00, A61B17/58, C22C23/06, A61L31/14K, A61L31/02B