US3467097A - Dual medicinal vial - Google Patents
Dual medicinal vial Download PDFInfo
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- US3467097A US3467097A US3467097DA US3467097A US 3467097 A US3467097 A US 3467097A US 3467097D A US3467097D A US 3467097DA US 3467097 A US3467097 A US 3467097A
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- vial
- plug
- casing
- diameter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
- B65D25/08—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
- B65D25/082—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents the partition being in the form of a plug or the like which is removed by increasing or decreasing the pressure within the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2041—Separating means having removable plugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/08—Mixing
Definitions
- This patent further describes a generally cylindrical irst casing adapted to t over a portion of the vial and a second generally cylindrical casing adapted to fit over the other end of the vial, the casing forming a closed housing for the vial and the second casing having at its closed end a reentrant portion with a closed end wall.
- the second casing is adapted after removal of both of the casings from the vial to be replaced over the vial in place of the first casing with the closed end of the reentrant portion engaging the top of a stopper positioned at the top open end of the vial.
- This invention relates to a medicament vial and more particularly to a vial having a pair of compartments, one of which may contain a medicament in the form of a dry lyophilized powder and the other of which may contain a diluent for the same.
- a medicament vial having a pair of compartments, one of which may contain a medicament in the form of a dry lyophilized powder and the other of which may contain a diluent for the same.
- Such two compartment medicament vials are known but it is the primary purpose of this invention to provide such a vial in which the lyophilization may take place within the medicament in one compartment of the vial and this compartment then sealed in the absence of air whether sterilized or not or any inert gas or other aeriform fluid such as nitrogen.
- a number of injectable medicaments are stable for but short periods of time, once they are in solution.
- Such medications are normally supplied to the physician in a dry form which he reconstitutes by adding a diluent to same immediately preceding injection of same.
- the drug manufacturers have adopted a procedure wherein a drug unstable in solution is first reduced to a solution for the purpose of sterilizing same, and then returned to a dry state by a process of quick freezing and vacuum evacuation of the liquid, commonly referred to in the drug trade as lyophilization.
- Some injectable medications, such as rabies are very diicult to process, as no air should come in contact, even though sterile, with the dried product.
- This invention has as a primary feature thereof a twocompartment vial wherein the solution to be lyophilized can be put in one compartment.
- a resilient plug intended M1ce to seal and separate the dry compartment from its diluent chamber is also set in said vial immediately above a center sealing ring so that the entire unit may be placed within the freeze dry and vacuum cabinet.
- this sealing center disk is at points greater than the diameter of the Vial itself in its largest portion, it at all times maintains a fixed position, yet intermediate to these points, its diameter is less than the largest diameter of the vial, and permits complete evacuation of the liquid in the lyophilizing cycle.
- the resilient plug is set in its sealing position by rods within the lyophilizer without necessitating removal of the vial prior to such sealing.
- FIGURE 1 is a vertical section of the vial of this invention as it is placed in the lyophilizer;
- FIGURE 2 is an enlarged vertical section of the completed vial with the lyopholized material sealed therein as Well as the diluent and in which the entire vial is incapsulated in outer package;
- FIGURE 3 is a section similar to FIGURE 2 showing the condition of the invention 4as the diluent is introduced into the section containing a lyophilized powder;
- FIGURE 4 is a section of the vial of this invention in its condition to be used to ll a conventional syringe;
- FIGURE 5 is a plan view of the center plug
- FIGURE 6 is a side view of the center plug used in connection with this invention.
- 10 indicates a vial preferably of glass but which in many instances may be of any of the well known plastic materials and which is generally cylindrical in form being closed at the bottom 11 and having an open top 12.
- a plug 13 formed of a resilient material is utilized and is particularly illustrated in FIGURES 5 and 6. This plug has an exterior diameter indicated at 14 which is larger than the interior diameter indicated at 15 of the vial at any point thereof.
- the plug 13, however, has a plurality of portions 16 wherein the diameter is reduced for purposes hereinafter indicated.
- the plug 13 has an upper portion 17 and a lower portion 18 which are substantially mirror images of each other. Midway of the two portions 17 and 18 is a point 19 which, if practical, would come to a sharp V-shaped point but due to manufacturing difficulties is actually a very short cylindrical section 4bordered by tapered walls 20 and 21.
- the outwardly extending portions 22 which extend the full diameter of the plug are arcuate in shape on the edge toward the center line as indicated while the spaces 23 between the portions 22 are of reduced diameter which diameter is nevertheless greater than the diameter 19. The result is that the entire V- shaped or tapered portions 19 and 20 extend completely around the plug 13.
- the vial 10 has an indentation 24 which forces the glass inwardly in a generally V-shaped cross section 25.
- This indentation is formed while the vial 10 is in a formable state such as heated glass and the indentation 24 is formed by applying a sharp pointed blade to the revolving vial with a purpose of having a sharp pointed end 26 on the indentation.
- a perfectly sharp point is not generally obtained due to the diiculties of manufacture but the point 26 thereof though rounded is intended to have substantially no longitudinal length.
- a second plug 27 of resilient material is provided as a closure for the open end 12 and normally has a central bore 28 extending only part-way therethrough and a pair of rings 29 and 30 formed thereon.
- the rings 29 and 30 in their extended state are of greater diameter than the interior diameter 15 of the vial so as to be received in the vial with a press-fit which nevertheless permits the plug 27 to have a sliding movement within the vial when the natural resistance thereto is overcome.
- the package is completed by providing an outer casing 31 comprising a generally cylindrical upper portion 32 having an internally enlarged portion 33 forming a shoulder 34 and a generally cylindrical portion 35 having a portion 36 of reduced outward diameter so that the upper and lower portions 32 and 33 may be joined with a lapped joint as shown in FIGURE 2.
- the upper portion 32 is closed with an end wall as shown at 37.
- the lower portion 35 has an end wall 38 of annular shape connecting with an upstanding re-entrant cylindrical portion 39 which is closed by a circular portion 40 extending across the cylindrical portion 39.
- the device of this invention is filled with a Imedicament 41 of the type which is to be lyophilized.
- This generally includes mixing the medicament 41 with a liquid such as water.
- the plug 13 is inserted in the vital as is shown in FIGURE 1 in which condition it is not seated upon the indentation 24 so that communication through the openings 16 into the interior of the vial is maintained.
- the device as disclosed in FIGURE 1 having been placed in the lyophilizer it may be freezed dry removing all of the liquid and freezing the powder and presenting a Vacuum. Thereafter a proper tool may be inserted to depress the plug 13 so as to seat the same on the indentation 24, which is the condition shown in FIGURE 2.
- the beveled edges 20 and 21 conform to the inwardly beveled edges of the indentation 24 and that the hardly perceptible section 19 conforms to the tip of the indentation 24 thus forming a three-point seal between the plug 13 and the indentation 24 which securely seals the medicament in the bottom of the vial and prevents the entrance of any air.
- the space 40 may very well be a vacuum.
- a diluent 41 is inserted into the vial and plug 27 placed therein to contain the diluent.
- the casing 31 is then placed around the vial with the parts 32 and 33 jointed together as shown in FIGURE 2.
- FIGURE 2 therefore represents the condition in which this invention, after filling, is shipped or stored.
- the casing 31 is entirely removed and the upper portion 32 is discarded while the lower portion 3S is reversed and placed upon the top as shown in FIGURE 3 in which case the wall 40 engages the top of the plug 27.
- Downward pressure on the portion 35 will be thus communicated to the plug 27 and to the fiuid 41, which pressure is sufficient to force the plug 13 over the indentation 24 into the position shown in FIGURE 3.
- This permits the liquid 41 to mix with the powder.
- the device is inverted as shown in FIGURE 4 and a syringe 50 having needle 51 is utilized.
- the needle 51 pierces the thin wall of plug 27 and permits Withdrawal of the mixed diluent fluid and powder into the syringe as shown at 52 in FIGURE 4.
- the syringe When the syringe is thus properly loaded it will be removed from the vial and is in condition for the contents to be injected into the patient.
- a medicament vial assembly comprising a cylindrical vial having an open end, a closed end, and a cylindrical wall restricted immediate its ends by an annular restriction having a V-shaped cross-section, there being situated in the vial a resilient cylindrical walled plug having top and bottom walls, said plug also having around its outer annular wall, alternating peripheral portions of greater diameter than the largest internal diameter of the vial and portions of smaller diameter than the largest internal diameter of the vial, the cylindrical wall of the plug being provided intermediate said top land bottom walls with an annular indentation having a V-shaped cross-section, the indentation being adapted, when positioned over the restriction in the wall of the vial, to form a seal with the restriction, said peripheral portions permitting liquid evaporation to take place above and below the plug during lyophilization.
- a medicament vial as set forth in claim 1 in which said container is provided with a second resilient stopper adapted to have a press fit 'within said container but slidable therein upon the application of pressure; said second stopper being adapted to close said open end after said first stopper has been positioned over said restriction and being pierceable by a hypodermc needle.
- a medicament vial as set forth in claim 2 having a generallyV cylindrical first casing fitted over a portion of said vial and a second generally cylindrical casing fitted over ⁇ the other end of said vial, said casing being connected together to form a closed housing for said vial and said second casing having at its closed end a re-entrant portion with a closed end wall, said second casing being adapted after removal of both said casings from said vial to be replaced over said vial in place of said first casing with the closed end of said re-entrant portion engaging the copy of said second stopper.
- a medicament vial as set forth in claim 2 in which said second stopper is generally cylindrical in form but is provided with a pair of outwardly extending spaced rings and a central passage extending part-way only through said second stopper.
- a device as set forth in claim 4 having a generally cylindrically first casing fitted over ⁇ a portion of said vial and a second generally cylindrical casing fitted over the other end of said vial, said casings being connected together to form ya closed housing for said vial and said second casing having at its closed end a re-entrant portion with a closed end wall, said second casing being adapted, after removal of both said casings from said vial, to be replaced over said vial in place of said first casing with the closed end of saidre-entrant portion engaging the top of said second stopper.
Description
Sept. 16, 1969 R. w. OGLE DUAL MEDICINAL VIAL Filed July 6, 1965 INVENTOR.
l v L United States Patent O U.S. Cl. 12S-272 5 Claims ABSTRACT OF THE DISCLOSURE This patent describes a novel medicament vial comprising a container having an open end and a closed end; the Walls of the container being restricted intermediate the ends thereof by a restriction having a substantially V-shaped cross section terminating in a substantially sharp small V point; a resilient stopper in said container having an outer extreme width greater than the width of said container, the stopper having portions of lesser width than the Width of said container, and having its outward perimeter provided with a sharp small V pointed in cross section indentation adapted when positioned over the restriction to seal upon both walls and the point of the restriction. A second stopper is inserted in the open end of the vial. This patent further describes a generally cylindrical irst casing adapted to t over a portion of the vial and a second generally cylindrical casing adapted to fit over the other end of the vial, the casing forming a closed housing for the vial and the second casing having at its closed end a reentrant portion with a closed end wall. The second casing is adapted after removal of both of the casings from the vial to be replaced over the vial in place of the first casing with the closed end of the reentrant portion engaging the top of a stopper positioned at the top open end of the vial.
This invention relates to a medicament vial and more particularly to a vial having a pair of compartments, one of which may contain a medicament in the form of a dry lyophilized powder and the other of which may contain a diluent for the same. Such two compartment medicament vials are known but it is the primary purpose of this invention to provide such a vial in which the lyophilization may take place within the medicament in one compartment of the vial and this compartment then sealed in the absence of air whether sterilized or not or any inert gas or other aeriform fluid such as nitrogen.
A number of injectable medicaments are stable for but short periods of time, once they are in solution. Such medications are normally supplied to the physician in a dry form which he reconstitutes by adding a diluent to same immediately preceding injection of same. In recent years, the drug manufacturers have adopted a procedure wherein a drug unstable in solution is first reduced to a solution for the purpose of sterilizing same, and then returned to a dry state by a process of quick freezing and vacuum evacuation of the liquid, commonly referred to in the drug trade as lyophilization. Some injectable medications, such as rabies, are very diicult to process, as no air should come in contact, even though sterile, with the dried product. Current two-compartment devices widely marketed, though providing for an effective two-compartment system, nevertheless necessitates their removal from the vacuum chambers in order to set fthe rubber plugs commonly used to divide the dry and liquid compartments.
This invention has as a primary feature thereof a twocompartment vial wherein the solution to be lyophilized can be put in one compartment. A resilient plug intended M1ce to seal and separate the dry compartment from its diluent chamber is also set in said vial immediately above a center sealing ring so that the entire unit may be placed within the freeze dry and vacuum cabinet. However, due to the fact that the diameter of this sealing center disk is at points greater than the diameter of the Vial itself in its largest portion, it at all times maintains a fixed position, yet intermediate to these points, its diameter is less than the largest diameter of the vial, and permits complete evacuation of the liquid in the lyophilizing cycle. At the termination of this cycle the resilient plug is set in its sealing position by rods within the lyophilizer without necessitating removal of the vial prior to such sealing.
These and other objects, features and advantages will be apparent from the annexed specification in which:
FIGURE 1 is a vertical section of the vial of this invention as it is placed in the lyophilizer;
FIGURE 2 is an enlarged vertical section of the completed vial with the lyopholized material sealed therein as Well as the diluent and in which the entire vial is incapsulated in outer package;
FIGURE 3 is a section similar to FIGURE 2 showing the condition of the invention 4as the diluent is introduced into the section containing a lyophilized powder;
FIGURE 4 is a section of the vial of this invention in its condition to be used to ll a conventional syringe;
FIGURE 5 is a plan view of the center plug; and
FIGURE 6 is a side view of the center plug used in connection with this invention.
Referring now more particularly to the drawings, 10 indicates a vial preferably of glass but which in many instances may be of any of the well known plastic materials and which is generally cylindrical in form being closed at the bottom 11 and having an open top 12. A plug 13 formed of a resilient material is utilized and is particularly illustrated in FIGURES 5 and 6. This plug has an exterior diameter indicated at 14 which is larger than the interior diameter indicated at 15 of the vial at any point thereof. The plug 13, however, has a plurality of portions 16 wherein the diameter is reduced for purposes hereinafter indicated.
Referringnow more particularly to FIGURE 6 it will be noted that the plug 13 has an upper portion 17 and a lower portion 18 which are substantially mirror images of each other. Midway of the two portions 17 and 18 is a point 19 which, if practical, would come to a sharp V-shaped point but due to manufacturing difficulties is actually a very short cylindrical section 4bordered by tapered walls 20 and 21. The outwardly extending portions 22 which extend the full diameter of the plug are arcuate in shape on the edge toward the center line as indicated while the spaces 23 between the portions 22 are of reduced diameter which diameter is nevertheless greater than the diameter 19. The result is that the entire V- shaped or tapered portions 19 and 20 extend completely around the plug 13. Intermediate its ends the vial 10 has an indentation 24 which forces the glass inwardly in a generally V-shaped cross section 25. This indentation is formed while the vial 10 is in a formable state such as heated glass and the indentation 24 is formed by applying a sharp pointed blade to the revolving vial with a purpose of having a sharp pointed end 26 on the indentation. However, as indicated a perfectly sharp point is not generally obtained due to the diiculties of manufacture but the point 26 thereof though rounded is intended to have substantially no longitudinal length.
A second plug 27 of resilient material is provided as a closure for the open end 12 and normally has a central bore 28 extending only part-way therethrough and a pair of rings 29 and 30 formed thereon. The rings 29 and 30 in their extended state are of greater diameter than the interior diameter 15 of the vial so as to be received in the vial with a press-fit which nevertheless permits the plug 27 to have a sliding movement within the vial when the natural resistance thereto is overcome.
The package is completed by providing an outer casing 31 comprisinga generally cylindrical upper portion 32 having an internally enlarged portion 33 forming a shoulder 34 and a generally cylindrical portion 35 having a portion 36 of reduced outward diameter so that the upper and lower portions 32 and 33 may be joined with a lapped joint as shown in FIGURE 2. The upper portion 32 is closed with an end wall as shown at 37. The lower portion 35 has an end wall 38 of annular shape connecting with an upstanding re-entrant cylindrical portion 39 which is closed by a circular portion 40 extending across the cylindrical portion 39.
In use the device of this invention is filled with a Imedicament 41 of the type which is to be lyophilized. This generally includes mixing the medicament 41 with a liquid such as water. The plug 13 is inserted in the vital as is shown in FIGURE 1 in which condition it is not seated upon the indentation 24 so that communication through the openings 16 into the interior of the vial is maintained. Thus, the device as disclosed in FIGURE 1 having been placed in the lyophilizer it may be freezed dry removing all of the liquid and freezing the powder and presenting a Vacuum. Thereafter a proper tool may be inserted to depress the plug 13 so as to seat the same on the indentation 24, which is the condition shown in FIGURE 2. It will be noted that the beveled edges 20 and 21 conform to the inwardly beveled edges of the indentation 24 and that the hardly perceptible section 19 conforms to the tip of the indentation 24 thus forming a three-point seal between the plug 13 and the indentation 24 which securely seals the medicament in the bottom of the vial and prevents the entrance of any air. In fact, if the medicament does not entirely fill the space the space 40 may very well be a vacuum. Thereafter the device is removed from the lyophilizer, a diluent 41 is inserted into the vial and plug 27 placed therein to contain the diluent. The casing 31 is then placed around the vial with the parts 32 and 33 jointed together as shown in FIGURE 2. FIGURE 2 therefore represents the condition in which this invention, after filling, is shipped or stored.
When it is desired to use the device of this invention, the casing 31 is entirely removed and the upper portion 32 is discarded while the lower portion 3S is reversed and placed upon the top as shown in FIGURE 3 in which case the wall 40 engages the top of the plug 27. Downward pressure on the portion 35 will be thus communicated to the plug 27 and to the fiuid 41, which pressure is sufficient to force the plug 13 over the indentation 24 into the position shown in FIGURE 3. This, of course, permits the liquid 41 to mix with the powder. After the liquid and powder have been thoroughly mixed the device is inverted as shown in FIGURE 4 and a syringe 50 having needle 51 is utilized. The needle 51 pierces the thin wall of plug 27 and permits Withdrawal of the mixed diluent fluid and powder into the syringe as shown at 52 in FIGURE 4. When the syringe is thus properly loaded it will be removed from the vial and is in condition for the contents to be injected into the patient.
It will be noted that when the syringe needle 51 pierces the thin wall of plug 27 and the plunger of the syringe is withdrawn the plug 27, because of its sliding fit within the vial 10, will pass upwardly in the vial as shown in FIGURE 4 withdrawing the fluid into the syringe as indicated at 52 without the introduction of any air into the vial 10. This is a feature which this invention has in common with my copending United States patent application Ser. No. 467,858, filed June 29, 1965, now United States Patent No. 3,321,098, issued May 23, 1967.
While there has been -described what is at present considered a preferred embodiment of the present invention, it will be appreciated by those skilled in the art that various changes and modifications can be made therein without departing from the essence of the invention and it is intended to cover herein all such charges and modifications as come within the true spirit .and scope of the appended claims.
I claim:
1. A medicament vial assembly comprising a cylindrical vial having an open end, a closed end, and a cylindrical wall restricted immediate its ends by an annular restriction having a V-shaped cross-section, there being situated in the vial a resilient cylindrical walled plug having top and bottom walls, said plug also having around its outer annular wall, alternating peripheral portions of greater diameter than the largest internal diameter of the vial and portions of smaller diameter than the largest internal diameter of the vial, the cylindrical wall of the plug being provided intermediate said top land bottom walls with an annular indentation having a V-shaped cross-section, the indentation being adapted, when positioned over the restriction in the wall of the vial, to form a seal with the restriction, said peripheral portions permitting liquid evaporation to take place above and below the plug during lyophilization.
2. A medicament vial as set forth in claim 1 in which said container is provided with a second resilient stopper adapted to have a press fit 'within said container but slidable therein upon the application of pressure; said second stopper being adapted to close said open end after said first stopper has been positioned over said restriction and being pierceable by a hypodermc needle.
3. A medicament vial as set forth in claim 2 having a generallyV cylindrical first casing fitted over a portion of said vial and a second generally cylindrical casing fitted over `the other end of said vial, said casing being connected together to form a closed housing for said vial and said second casing having at its closed end a re-entrant portion with a closed end wall, said second casing being adapted after removal of both said casings from said vial to be replaced over said vial in place of said first casing with the closed end of said re-entrant portion engaging the copy of said second stopper.
4. A medicament vial as set forth in claim 2 in which said second stopper is generally cylindrical in form but is provided with a pair of outwardly extending spaced rings and a central passage extending part-way only through said second stopper.
5. A device as set forth in claim 4 having a generally cylindrically first casing fitted over `a portion of said vial and a second generally cylindrical casing fitted over the other end of said vial, said casings being connected together to form ya closed housing for said vial and said second casing having at its closed end a re-entrant portion with a closed end wall, said second casing being adapted, after removal of both said casings from said vial, to be replaced over said vial in place of said first casing with the closed end of saidre-entrant portion engaging the top of said second stopper.
References Cited UNITED STATES PATENTS 2,610,628 9/ 1952 Lockhart 128-272 2,695,614 11/ 1954 Lockhart 128-272 2,764,157 9/ 1956 Oliva et al 128--272 2,848,130 8/1958 Jesnig.
DALTON L. TRULUCK, Primary Examiner U.S. Cl. X.R. 21S-6
Applications Claiming Priority (1)
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US46981265A | 1965-07-06 | 1965-07-06 |
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US3467097A true US3467097A (en) | 1969-09-16 |
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Family Applications (1)
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US3467097D Expired - Lifetime US3467097A (en) | 1965-07-06 | 1965-07-06 | Dual medicinal vial |
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US (1) | US3467097A (en) |
AT (1) | AT269361B (en) |
BE (1) | BE683613A (en) |
CH (1) | CH448382A (en) |
DE (1) | DE1296312B (en) |
DK (1) | DK115655B (en) |
ES (1) | ES133382Y (en) |
FR (1) | FR1485201A (en) |
GB (1) | GB1120897A (en) |
IL (1) | IL26065A (en) |
NL (1) | NL6609383A (en) |
NO (1) | NO115629B (en) |
SE (1) | SE354573B (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3857392A (en) * | 1969-06-04 | 1974-12-31 | Ims Ltd | Intravenous container with dislodgeable septum and dislodging piercer |
US3858580A (en) * | 1969-06-04 | 1975-01-07 | Ims Ltd | Intravenous container mixing assembly |
US3941128A (en) * | 1970-11-10 | 1976-03-02 | Affiliated Hospital Products, Inc. | Fluid dispensing arrangement |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
EP0021123A1 (en) * | 1979-06-08 | 1981-01-07 | Hoechst Aktiengesellschaft | Sprayer |
US4470505A (en) * | 1983-01-26 | 1984-09-11 | Paul Korwin | Method and apparatus for storing, mixing and delivering dental amalgam |
US4552277A (en) * | 1984-06-04 | 1985-11-12 | Richardson Robert D | Protective shield device for use with medicine vial and the like |
US4727985A (en) * | 1986-02-24 | 1988-03-01 | The Boc Group, Inc. | Mixing and dispensing apparatus |
US4941876A (en) * | 1986-04-10 | 1990-07-17 | Medicorp Holding S.A. | Device for conditioning liquids or liquid and solid substances |
US4968299A (en) * | 1987-07-02 | 1990-11-06 | Kabivitrum Ab | Method and device for injection |
US5188615A (en) * | 1990-11-19 | 1993-02-23 | Habley Medical Technology Corp. | Mixing vial |
US5352196A (en) * | 1990-11-19 | 1994-10-04 | Habley Medical Technology Corporation | Mixing vial |
US20090314781A1 (en) * | 2007-01-25 | 2009-12-24 | Michael Paul | Closure for filling and sealing receptacles containing medicinal fluids and method for filling a receptacle with a medicinal fluid and sealing the receptacle |
US20130018352A1 (en) * | 2011-07-12 | 2013-01-17 | Kuo-Cheng Wu | Multi-Medicament Container |
US20140182742A1 (en) * | 2012-11-29 | 2014-07-03 | Board Of Regents, The University Of Texas System | Robotic infusion mixer and transportable cartridge |
EP2671561A4 (en) * | 2011-02-04 | 2016-01-20 | Terumo Corp | Medicine storage container |
CN105775293A (en) * | 2016-04-08 | 2016-07-20 | 苏州玄禾物联网科技有限公司 | Intelligent drive circulating type solution bottle |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2211104B (en) * | 1987-10-13 | 1991-10-02 | Wilson Dr Louise Caroline | Syringe arrangment |
DE3806562A1 (en) * | 1988-03-01 | 1989-09-14 | Alpha Therapeutic Gmbh | TWO CHAMBER SYRINGE WITH A FILLING OF ACTIVITY SENSITIVE HUMAN PROTEIN AS AN ACTIVE SUBSTANCE |
ES2115201T3 (en) * | 1992-12-15 | 1998-06-16 | Sanofi Sa | DEVICE FOR THE PREPARATION OF A SOLUTION, A SUSPENSION OR AN EMULSION OF A MEDICINAL SUBSTANCE. |
KR960704591A (en) * | 1994-05-25 | 1996-10-09 | 메이어 가브리엘 | DEVICE FOR THE PREPARATION FO A SOLUTION.A SUSPENSION OR AN EMULSION OF A MEDICINAL SUBSTANCE |
US10369077B2 (en) * | 2017-05-31 | 2019-08-06 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using the same |
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US2610628A (en) * | 1950-05-09 | 1952-09-16 | Compule Corp | Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures |
US2695614A (en) * | 1952-12-10 | 1954-11-30 | Compule Corp | Plural-compartment admixing vial |
US2764157A (en) * | 1953-12-01 | 1956-09-25 | Oliva Juan Fernandez | Ampules |
US2848130A (en) * | 1953-10-07 | 1958-08-19 | Duo Vent Vacuum Closure Compan | Pressure resistant closures |
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DE613488C (en) * | 1931-09-16 | 1935-05-20 | Milano Novak Dr | Double ampoule |
CH255255A (en) * | 1946-12-24 | 1948-06-15 | Junod Margot | Bulb. |
DE961289C (en) * | 1952-10-05 | 1957-04-04 | Dr Med Dent Wilhelm Eisenberg | Two-chambered ampoule designed for separate storage and for mixing the components of an agent to be sprayed |
DE1074827B (en) * | 1955-05-20 | 1960-02-04 | Laboratoires dAntibiotiques et de Biologie, Paris | Injection ampoule |
DE1826297U (en) * | 1958-06-26 | 1961-02-09 | Luis Juste Buil | MULTI-CHAMBER CONTAINER FOR SEPARATE FILLING AND STORAGE OF CHEMICAL, MEDICAL-THERAPEUTIC, COSMETIC AND THE LIKE. FABRICS. |
US3058467A (en) * | 1958-10-27 | 1962-10-16 | Faure Jean-Marie | Hypodermic syringes |
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1965
- 1965-07-06 US US3467097D patent/US3467097A/en not_active Expired - Lifetime
-
1966
- 1966-06-29 IL IL2606566A patent/IL26065A/en unknown
- 1966-06-30 FR FR67588A patent/FR1485201A/en not_active Expired
- 1966-07-04 CH CH969566A patent/CH448382A/en unknown
- 1966-07-04 BE BE683613D patent/BE683613A/xx unknown
- 1966-07-05 DE DEO11780A patent/DE1296312B/en active Pending
- 1966-07-05 DK DK347466A patent/DK115655B/en unknown
- 1966-07-05 NL NL6609383A patent/NL6609383A/xx unknown
- 1966-07-05 NO NO163794A patent/NO115629B/no unknown
- 1966-07-05 SE SE914866A patent/SE354573B/xx unknown
- 1966-07-06 AT AT646266A patent/AT269361B/en active
- 1966-07-06 GB GB3042966A patent/GB1120897A/en not_active Expired
-
1968
- 1968-01-15 ES ES1966133382U patent/ES133382Y/en not_active Expired
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US2610628A (en) * | 1950-05-09 | 1952-09-16 | Compule Corp | Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures |
US2695614A (en) * | 1952-12-10 | 1954-11-30 | Compule Corp | Plural-compartment admixing vial |
US2848130A (en) * | 1953-10-07 | 1958-08-19 | Duo Vent Vacuum Closure Compan | Pressure resistant closures |
US2764157A (en) * | 1953-12-01 | 1956-09-25 | Oliva Juan Fernandez | Ampules |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3857392A (en) * | 1969-06-04 | 1974-12-31 | Ims Ltd | Intravenous container with dislodgeable septum and dislodging piercer |
US3858580A (en) * | 1969-06-04 | 1975-01-07 | Ims Ltd | Intravenous container mixing assembly |
US3941128A (en) * | 1970-11-10 | 1976-03-02 | Affiliated Hospital Products, Inc. | Fluid dispensing arrangement |
USRE29062E (en) * | 1972-11-01 | 1976-12-07 | Ims Limited | Intravenous container mixing assembly |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US4031892A (en) * | 1974-07-18 | 1977-06-28 | Ampoules Corporation | Two-chamber mixing syringe |
EP0021123A1 (en) * | 1979-06-08 | 1981-01-07 | Hoechst Aktiengesellschaft | Sprayer |
US4470505A (en) * | 1983-01-26 | 1984-09-11 | Paul Korwin | Method and apparatus for storing, mixing and delivering dental amalgam |
US4552277A (en) * | 1984-06-04 | 1985-11-12 | Richardson Robert D | Protective shield device for use with medicine vial and the like |
US4727985A (en) * | 1986-02-24 | 1988-03-01 | The Boc Group, Inc. | Mixing and dispensing apparatus |
US4941876A (en) * | 1986-04-10 | 1990-07-17 | Medicorp Holding S.A. | Device for conditioning liquids or liquid and solid substances |
US4968299A (en) * | 1987-07-02 | 1990-11-06 | Kabivitrum Ab | Method and device for injection |
US5188615A (en) * | 1990-11-19 | 1993-02-23 | Habley Medical Technology Corp. | Mixing vial |
US5352196A (en) * | 1990-11-19 | 1994-10-04 | Habley Medical Technology Corporation | Mixing vial |
US20090314781A1 (en) * | 2007-01-25 | 2009-12-24 | Michael Paul | Closure for filling and sealing receptacles containing medicinal fluids and method for filling a receptacle with a medicinal fluid and sealing the receptacle |
US8763798B2 (en) * | 2007-01-25 | 2014-07-01 | Fresenius Medical Care Deutschland Gmbh | Closure for filling and sealing receptacles containing medicinal fluids and method for filling a receptacle with a medicinal fluid and sealing the receptacle |
EP2671561A4 (en) * | 2011-02-04 | 2016-01-20 | Terumo Corp | Medicine storage container |
JP6038658B2 (en) * | 2011-02-04 | 2016-12-07 | テルモ株式会社 | Drug storage container |
US20130018352A1 (en) * | 2011-07-12 | 2013-01-17 | Kuo-Cheng Wu | Multi-Medicament Container |
US9707157B2 (en) * | 2011-07-12 | 2017-07-18 | Kuo-Cheng Wu | Multi-medicament container |
US20140182742A1 (en) * | 2012-11-29 | 2014-07-03 | Board Of Regents, The University Of Texas System | Robotic infusion mixer and transportable cartridge |
CN105775293A (en) * | 2016-04-08 | 2016-07-20 | 苏州玄禾物联网科技有限公司 | Intelligent drive circulating type solution bottle |
CN105775293B (en) * | 2016-04-08 | 2017-12-22 | 苏州玄禾物联网科技有限公司 | A kind of circulating solution bottle of intelligent drives |
Also Published As
Publication number | Publication date |
---|---|
SE354573B (en) | 1973-03-19 |
BE683613A (en) | 1967-01-04 |
ES133382U (en) | 1968-02-16 |
DK115655B (en) | 1969-10-27 |
ES133382Y (en) | 1969-04-16 |
AT269361B (en) | 1969-03-10 |
GB1120897A (en) | 1968-07-24 |
NL6609383A (en) | 1967-01-09 |
DE1296312B (en) | 1969-05-29 |
CH448382A (en) | 1967-12-15 |
FR1485201A (en) | 1967-06-16 |
NO115629B (en) | 1968-11-04 |
IL26065A (en) | 1970-09-17 |
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