US2920012A - Therapeutic compositions for inhibiting carbonic anhydrase activity - Google Patents
Therapeutic compositions for inhibiting carbonic anhydrase activity Download PDFInfo
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- US2920012A US2920012A US532113A US53211355A US2920012A US 2920012 A US2920012 A US 2920012A US 532113 A US532113 A US 532113A US 53211355 A US53211355 A US 53211355A US 2920012 A US2920012 A US 2920012A
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- carbonic anhydrase
- triazine
- carbanilate
- therapeutic compositions
- amino
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Definitions
- This invention relates to therapeutic compositions and 2 more particularly to therapeutic compositions which are eifective to inhibit carbonic anhydrase activity.
- compositions comprising a compound having the fortmula:
- the invention also includes the method of inhibiting carbonic anhydrase activity through the use of the above-noted compounds.
- carbonic anhydrase activity indirectly determines the number of hydrogen ions which are available to re- .place sodium ions inbuffercompounds from the blood, suchas, for example, disodium phosphate-rand sodium bicarbonate.
- the sodium .ions thus replaced are conserved and return to the blood, and carbonic acid formed in the above reaction catalyzed by carbonic anhydrase also returns to the blood.
- the diuretic action of these triazine compounds is believed to be due to the inhibition of tubular reabsorption brought about by a partial anoxia from the inhibition of respiratory enzymes involved in the tubular reabsorption of water and sodium chloride.
- the increase in diuretic action noted when one of these'tria'zine compounds is included in the therapeutic" compositions'of the invention is more than can be accounted for by the additive eifect of the carbanilate compound andthe triazine compound on the basis of their action individually, as' is shown by the tests described hereinafter.
- nontoxic salts of 2, 4- diamino s-triazine, 2-amino-4-[3-carboxy ethyl amino s-triazine, 2,4-(f3-carboxy ethyl amino) striazine, 2- amino-4-ani1ino-1,3,5-triazine and 2-amino-4-(p-chloroanilino)-l,3,5-triazine which are useful as components of the compositions of the invention may be mentioned the hydrochloride, sulfate, phosphate and tartrate salts.
- the salts of the alkali metals, ammonia and amines may also be utilized.
- the amount of triazine component, when includedin the compositions of the invention may be varied considerably and may be, for example, approximately 27% by weight.
- the p-sulfamyl carbanilate compounds specified herein are not only compatible with other components employed in therapeutic compositions, but they are also stable and nontoxic.
- intraperitoneal doses of; p-Sulfamyl fl-hydroxy ethyl carbanilate .up to 1600 mg/kg were tolerated by. male white rats, and only three animalsout of .a group of ..nine. receiving 1800 Ing /kg. intraperitoneally died.1.
- oral doses up to 1500 rngjlgg. of this carbanilate. compound did not prpduce any ill effectjn male whiterats.
- Three groups of white rats, with six animals in each group received 6 00 QOQ and 1200 mg./kg. respectively of p-sulfamyl fl-hydr'oxy ethyl carbanilate-per day for twelve days and gross pathology after being sacrificed showed "a" normal and autopsied on the thirteenth day.
- the carbanilate compounds of the novel therapeutic compositions of the invention have the formula:
- compositions of the present invention comprise a compound of the above mentioned class and a pharmaceutical carrier which may be either a liquid or solid material. It is preferred that the pharmaceutical carrier be a solid material such as, for example, starch, gelatin, lactose, talc, calcium stearate or the like. Any of the pharmaceutical carriers conventionally used in therapeutic compositions may be utilized where such materials are compatible with the aforementioned carbanilate compounds. These compositions include tablets, capsules and the like, and may include a liquid pharmaceutical carrier and be in the form of solutions, dispersions, suspensions, elixirs and the like.
- the percentage of the carbanilate compound incorporated in the therapeutic compositions of the invention may be varied considerably.
- Exemplary compositions may contain approximately 80% by weight of one of the above mentioned carbanilate compounds, although greater or smaller amounts than 80% may also be used in the practice of the invention.
- the daily dosage administered to a patient may also vary considerably, depending upon the patients condition and the amount prescribed by the physician in charge. In the case of edema, the daily dosage of these novel compositions may be such that the patient ingests on the order of 250 mg. to 500 mg. of one of the carbanilate compounds per day.
- Example 1 Therapeutic diuretic tablets were prepared having the following composition:
- G p-Sulfamyl fi-hydroxy ethyl carbanilate 0.500 Formoguanamine 0.250 Betaine hydrochloride 0.065 Corn starch U.S.P. 0.100 Calcium stearate 0.010 Talcum powder 0.005
- Example 2 Therapeutic diuretic tablets were prepared having the following composition:
- the tablets were prepared by first mixing the p-sulfamyl fl-hydroxy ethyl carbanilate, 2-amino-4-anilino-l,3,5-trtazine hydrochloride and betaine hydrochloride in the dry state. This mixture was then wet granulated with isopropyl alcohol (0.125 ml. per tablet) and water (0.125 ml. per tablet). The wet granulated mixture was thereafter dried on trays at a temperature of F. for 15 hours, and the dry mixture was ground in an oscillator using a No. 11 heavy wire screen. The corn starch, calcium stearate and talcum powder were added and, after thorough mixing, the mixture was compressed into tab ets.
- Example 3 The inhibition of carbonic anhydrase activity by psulfamyl allyl carbanilate was determined as follows:
- the carbonic anhydrase employed was prepared from rabbit red blood cells by the method of Keilin and Mann (Biochem. J. 34, 1166, 1940). The red blood cells were Washed three times with saline by centrifugation. To the washed cells (10 ml.) in a centrifuge tube were added distilled water (6 ml.), ethyl alcohol (4 ml.) and chloroform (5 ml.). The mixture was shaken well and centrifuged for 25 minutes at 2500 r.p.m. A three phase system was formed consisting of a top layer of enzyme solution, a central layer of denatured protein and a bottom layer of chloroform.
- the top layer was removed and the activity of the carbonic anhydrase determined by a modification of the meth 0d of Meldrum and Roughton (J. Physiol. 80, 116-124, 1934), which measures the catalytic effect of the carbonic anhydrase enzyme on the rate of evolution of carbon dioxide from sodium bicarbonate solutions when mixed with phosphate buffer of pH 6.8.
- a sodium bicarbonate solution (1.1 ml.) (0.2 M) (prepared by dissolving the sodium bicarbonate in a 0.02 M sodium hydroxide solution) was placed in the main compartment of a 15 ml.
- compositions of the invention corresponding to the above described compositions andgcontaining comparable amounts of p-sulfamyl ethyl carbanilate, p-sulfamyl, allyl carbanilate and one of the aforementioned triazine compounds may be prepared and are effective in the practice of the invention.
- compositions of the invention may be employed in the treatment of any condition where the inhibition of carbonic anhydrase activity will produce a beneficial result.
- a therapeutic composition comprising a compound having the formula:
- R represents a radical selected from the group consisting of ethyl, p-hydroxy ethyl and allyl, a compound selected from the group consisting of 2,4-diamino s-triazine, 2-amiuo-4-p-carboxy ethyl amino s-triazine, 2,4- (B-carboxy ethyl amino) s-triazine, 2-amino-4-anilino- 1,3,5-triazine, 2-amino-4-(p-chloroa-nilino)-1,3,5-triazine and the nontoxic salts thereof, and a pharmaceutical carrier.
- a therapeutic composition comprising p-sulfamyl a hydroxy ethyl carbanilate, 2-amino-4- -anilino-1,3,5-triazine and a pharmaceutical carrier.
- a therapeutic composition comprising p-sulfamyl ethyl carbanilate, 2-amino-4-anilino-1,3,5-triazine and a pharmaceutical carrier.
- a therapeutic composition comprising p-sulfamyl allyl carbanilate, 2-amino-4-anilino-1,3,5-triazine and a pharmaceutical carrier.
- a therapeutic composition comprising p-sulfamyl References Cited in the file of this patent U.S. Dispensatory, 25th ed., pp. 191-492.
Description
United States Patent "face 2,920,012 Patented Jan. 5, 1960 Robert G. Sanders, Clayton, Roland R. Read, Ladue, and Richard J. Palaz'zolo, Alfton, Mo., assignors to Warner-Lambert Pharmaceutical Company, St. Louis, Mo., a corporation of Delaware No Drawing. Application September 1, 1955 Serial No. 532,113
7 Claims. (Cl. 167-515) This invention relates to therapeutic compositions and 2 more particularly to therapeutic compositions which are eifective to inhibit carbonic anhydrase activity.
This application is a continuation-in-part of our applik cation Serial No. 456,639, filed September 16, ,1954, now -abandoned.
Briefly, the present invention is directed to therapeutic compositions comprising a compound having the fortmula:
NHCOOR -wherein Ris-ethyl, p-hydroxy ethyl or allyl, auda' pharmaceutical carrier. The invention also includes the method of inhibiting carbonic anhydrase activity through the use of the above-noted compounds.
Among the several objectsof the invention may'be noted the provision of therapeutic compositions and methods which are efiective to inhibit the activity of the enzyme carbonic anhydrase; the provision of such therapeutic compositions which are effective diuretic compositions; and the provision of therapeutic compositions of the class described which are stable and nontoxic. Other objects and features will be in part apparent and in part pointed out hereinafter. a
- The invention accordingly comprises the products and methods hereinafter described, the scope of the invention being indicated in the following claims.
The enzyme carbonic anhydrase plays an important role in the acidification of the urine through its catalysis of the reversible reaction:
The carbonic acid so formed yields hydrogen and bicarbonate ions through the reversible reaction:
'Thus, carbonic anhydrase activity indirectly determines the number of hydrogen ions which are available to re- .place sodium ions inbuffercompounds from the blood, suchas, for example, disodium phosphate-rand sodium bicarbonate. The sodium .ions thus replaced are conserved and return to the blood, and carbonic acid formed in the above reaction catalyzed by carbonic anhydrase also returns to the blood.
In accordance with the present invention, it has been found that carbonic anhydraseactivity can be effectively inhibited and the excretiontof water, sodium and potassium in the urine increased by the use of therapeutic compositions including a p-sulfamyl carbanilate compound having the following formula:
SiOgNHg NHCOOR wherein R is ethyl, S-hydroxy ethyl or allyl. The inhibition of carbonic anhydrase activity by the composi tionsof the present invention resultsin a reduction of hydrogen ions available for the acidification of the urine. As a consequence, the pH of the urine increases, fewer sodium ions of the buffer compounds are replaced by hydrogen ions, and larger amounts of sodium, chloride and bicarbonate are excreted in the urine. Further, because the formation of carbonic acid from carbon dioxide and water is inhibited, water excretion is increased. Thus, the diuretic action provided by the compositions of the inventionis useful to relieve edema, for example, caused bycongestive heart failure or other causes.
It has further been found in accordance with the present invention that when 2,4-diamino s-triazine (also known as formoguanamine), 2-arnino-4-B-carboxy ethyl amino, s triazine, 2,4-(fl-carboxy ethyl amino) s-triazine, 2 amino 4 anilino 1,3,5 triazine, 2 amino 4- (p-chloroanilino)-l,3,5-triazine or the nontoxic salts of one of these compounds is included in these novel therapeutic compositions, the amount of water, sodium and chloride, particularly the latter, secreted in the urine is markedly increased. The diuretic action of these triazine compounds is believed to be due to the inhibition of tubular reabsorption brought about by a partial anoxia from the inhibition of respiratory enzymes involved in the tubular reabsorption of water and sodium chloride. The increase in diuretic action noted when one of these'tria'zine compounds is included in the therapeutic" compositions'of the invention is more than can be accounted for by the additive eifect of the carbanilate compound andthe triazine compound on the basis of their action individually, as' is shown by the tests described hereinafter. Among the exemplary nontoxic salts of 2, 4- diamino s-triazine, 2-amino-4-[3-carboxy ethyl amino s-triazine, 2,4-(f3-carboxy ethyl amino) striazine, 2- amino-4-ani1ino-1,3,5-triazine and 2-amino-4-(p-chloroanilino)-l,3,5-triazine which are useful as components of the compositions of the invention may be mentioned the hydrochloride, sulfate, phosphate and tartrate salts. The salts of the alkali metals, ammonia and amines may also be utilized. The amount of triazine component, when includedin the compositions of the invention, may be varied considerably and may be, for example, approximately 27% by weight.
The p-sulfamyl carbanilate compounds specified herein are not only compatible with other components employed in therapeutic compositions, but they are also stable and nontoxic. For example, intraperitoneal doses of; p-Sulfamyl fl-hydroxy ethyl carbanilate .up to 1600 mg/kg, were tolerated by. male white rats, and only three animalsout of .a group of ..nine. receiving 1800 Ing /kg. intraperitoneally died.1.Moreover,. oral doses up to 1500 rngjlgg. of this carbanilate. compound did not prpduce any ill effectjn male whiterats. Three groups of white rats, with six animals in each group, received 6 00 QOQ and 1200 mg./kg. respectively of p-sulfamyl fl-hydr'oxy ethyl carbanilate-per day for twelve days and gross pathology after being sacrificed showed "a" normal and autopsied on the thirteenth day.
The carbanilate compounds of the novel therapeutic compositions of the invention have the formula:
NHCOOB.
wherein R represents ethyl, B-hydroxy ethyl or allyl. The therapeutic compositions of the present invention comprise a compound of the above mentioned class and a pharmaceutical carrier which may be either a liquid or solid material. It is preferred that the pharmaceutical carrier be a solid material such as, for example, starch, gelatin, lactose, talc, calcium stearate or the like. Any of the pharmaceutical carriers conventionally used in therapeutic compositions may be utilized where such materials are compatible with the aforementioned carbanilate compounds. These compositions include tablets, capsules and the like, and may include a liquid pharmaceutical carrier and be in the form of solutions, dispersions, suspensions, elixirs and the like.
The percentage of the carbanilate compound incorporated in the therapeutic compositions of the invention may be varied considerably. Exemplary compositions may contain approximately 80% by weight of one of the above mentioned carbanilate compounds, although greater or smaller amounts than 80% may also be used in the practice of the invention. The daily dosage administered to a patient may also vary considerably, depending upon the patients condition and the amount prescribed by the physician in charge. In the case of edema, the daily dosage of these novel compositions may be such that the patient ingests on the order of 250 mg. to 500 mg. of one of the carbanilate compounds per day.
The following examples illustrate the invention.
Example 1 Therapeutic diuretic tablets were prepared having the following composition:
Component: G. p-Sulfamyl fi-hydroxy ethyl carbanilate 0.500 Formoguanamine 0.250 Betaine hydrochloride 0.065 Corn starch U.S.P. 0.100 Calcium stearate 0.010 Talcum powder 0.005
Example 2 Therapeutic diuretic tablets were prepared having the following composition:
Component: G. p-Sulfamyl S-hydroxy ethyl carbanilate 0.250
2 amino 4 anilino-1,3,5-triazine hydrochloride 0.125 Betaine hydrochloride 0.065 Corn starch U.S.P. 0.100 Calcium stearate 0.010 Talcum powder 0.005
The tablets were prepared by first mixing the p-sulfamyl fl-hydroxy ethyl carbanilate, 2-amino-4-anilino-l,3,5-trtazine hydrochloride and betaine hydrochloride in the dry state. This mixture was then wet granulated with isopropyl alcohol (0.125 ml. per tablet) and water (0.125 ml. per tablet). The wet granulated mixture was thereafter dried on trays at a temperature of F. for 15 hours, and the dry mixture was ground in an oscillator using a No. 11 heavy wire screen. The corn starch, calcium stearate and talcum powder were added and, after thorough mixing, the mixture was compressed into tab ets.
Example 3 The inhibition of carbonic anhydrase activity by psulfamyl allyl carbanilate was determined as follows:
The carbonic anhydrase employed was prepared from rabbit red blood cells by the method of Keilin and Mann (Biochem. J. 34, 1166, 1940). The red blood cells were Washed three times with saline by centrifugation. To the washed cells (10 ml.) in a centrifuge tube were added distilled water (6 ml.), ethyl alcohol (4 ml.) and chloroform (5 ml.). The mixture was shaken well and centrifuged for 25 minutes at 2500 r.p.m. A three phase system was formed consisting of a top layer of enzyme solution, a central layer of denatured protein and a bottom layer of chloroform.
The top layer was removed and the activity of the carbonic anhydrase determined by a modification of the meth 0d of Meldrum and Roughton (J. Physiol. 80, 116-124, 1934), which measures the catalytic effect of the carbonic anhydrase enzyme on the rate of evolution of carbon dioxide from sodium bicarbonate solutions when mixed with phosphate buffer of pH 6.8. A sodium bicarbonate solution (1.1 ml.) (0.2 M) (prepared by dissolving the sodium bicarbonate in a 0.02 M sodium hydroxide solution) was placed in the main compartment of a 15 ml. Warburg flask while phosphate buffer (1 ml.) made by mixing equal volumes of disodium phosphate solution (0.2 M) and potassium acid phosphate solution (0.2 M) was placed in one side arm of the flask. The flask was attached to a manometer and the solution equilibrated 1 at 25 C in a shaking machine. The rate of carbon dioxide evolution in the presence of carbonic anhydrase enzyme solution (1 ml.) was measured and compared with a blank. It was found that at a concentration of l mg./ml. of p-sulfamyl allyl carbanilate 84% inhibition of carbonic anhydrase activity was effected when tested according to this method.
Other compositions of the invention corresponding to the above described compositions andgcontaining comparable amounts of p-sulfamyl ethyl carbanilate, p-sulfamyl, allyl carbanilate and one of the aforementioned triazine compounds may be prepared and are effective in the practice of the invention.
It will be understood, of course, that the therapeutic compositions of the invention may be employed in the treatment of any condition where the inhibition of carbonic anhydrase activity will produce a beneficial result.
In view of the above, it will be seen that the several objects of the invention are achieved and other advantageous results attained.
As various changes could be made in the above products and methods without departing from the scope of the invention, it is intended that all matter contained in the above description shall be interpreted as illustrative and not in a limiting sense.
We claim:
1. A therapeutic composition comprising a compound having the formula:
NHCOOR wherein R represents a radical selected from the group consisting of ethyl, p-hydroxy ethyl and allyl, a compound selected from the group consisting of 2,4-diamino s-triazine, 2-amiuo-4-p-carboxy ethyl amino s-triazine, 2,4- (B-carboxy ethyl amino) s-triazine, 2-amino-4-anilino- 1,3,5-triazine, 2-amino-4-(p-chloroa-nilino)-1,3,5-triazine and the nontoxic salts thereof, and a pharmaceutical carrier.
2. A therapeutic composition comprising p-sulfamyl a hydroxy ethyl carbanilate, 2-amino-4- -anilino-1,3,5-triazine and a pharmaceutical carrier.
3. A therapeutic composition comprising p-sulfamyl ethyl carbanilate, 2-amino-4-anilino-1,3,5-triazine and a pharmaceutical carrier.
4. A therapeutic composition comprising p-sulfamyl allyl carbanilate, 2-amino-4-anilino-1,3,5-triazine and a pharmaceutical carrier.
5. A therapeutic composition comprising p-sulfamyl References Cited in the file of this patent U.S. Dispensatory, 25th ed., pp. 191-492.
J. Am. Chem. Soc., vol. 72, November 1950, pp. 4893-4896.
Chem. Abst., vol. 41, 1947, pp. 4809-4811.
Vogl: Diuretic Ther., Williams and Wilkins Co., 1953, p. 47, Baltimore, Md.
I.A.M.A., vol. 151, No. 16, Apr. 18, 1953, p. 1430.
Claims (1)
1. A THERAPEUTIC COMPOSITION COMPRISING A COMPOUND HAVING THE FORMULA:
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| US532113A US2920012A (en) | 1955-09-01 | 1955-09-01 | Therapeutic compositions for inhibiting carbonic anhydrase activity |
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| US532113A US2920012A (en) | 1955-09-01 | 1955-09-01 | Therapeutic compositions for inhibiting carbonic anhydrase activity |
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| US4917108A (en) * | 1988-06-29 | 1990-04-17 | Mault James R | Oxygen consumption meter |
| US5836300A (en) * | 1996-03-11 | 1998-11-17 | Mault; James R. | Metabolic gas exchange and noninvasive cardiac output monitor |
| US6135107A (en) * | 1996-03-11 | 2000-10-24 | Mault; James R. | Metabolic gas exchange and noninvasive cardiac output monitor |
| US6277645B1 (en) | 1998-08-03 | 2001-08-21 | James R. Mault | Method and apparatus for respiratory gas analysis employing measurement of expired gas mass |
| US6309360B1 (en) | 1997-03-17 | 2001-10-30 | James R. Mault | Respiratory calorimeter |
| US20010044588A1 (en) * | 1996-02-22 | 2001-11-22 | Mault James R. | Monitoring system |
| US20020047867A1 (en) * | 2000-09-07 | 2002-04-25 | Mault James R | Image based diet logging |
| US20020055857A1 (en) * | 2000-10-31 | 2002-05-09 | Mault James R. | Method of assisting individuals in lifestyle control programs conducive to good health |
| US6402698B1 (en) | 1998-02-05 | 2002-06-11 | James R. Mault | Metabolic calorimeter employing respiratory gas analysis |
| US6406435B1 (en) | 1998-11-17 | 2002-06-18 | James R. Mault | Method and apparatus for the non-invasive determination of cardiac output |
| US20020133378A1 (en) * | 2000-10-13 | 2002-09-19 | Mault James R. | System and method of integrated calorie management |
| US20020138213A1 (en) * | 2001-03-02 | 2002-09-26 | Mault James R. | System and method of metabolic rate measurement |
| US6468222B1 (en) | 1999-08-02 | 2002-10-22 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
| US6478736B1 (en) | 1999-10-08 | 2002-11-12 | Healthetech, Inc. | Integrated calorie management system |
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| US20030023181A1 (en) * | 2001-07-26 | 2003-01-30 | Mault James R. | Gas analyzer of the fluorescent-film type particularly useful for respiratory analysis |
| US6517496B1 (en) | 1999-05-10 | 2003-02-11 | Healthetech, Inc. | Airway-based cardiac output monitor and methods for using same |
| US20030065274A1 (en) * | 1999-08-02 | 2003-04-03 | Mault James R. | Method of respiratory gas analysis using a metabolic calorimeter |
| US20030105407A1 (en) * | 2001-11-30 | 2003-06-05 | Pearce, Edwin M. | Disposable flow tube for respiratory gas analysis |
| US20030130595A1 (en) * | 2001-08-13 | 2003-07-10 | Mault James R. | Health improvement systems and methods |
| US20030130567A1 (en) * | 2002-01-09 | 2003-07-10 | Mault James R. | Health-related devices and methods |
| US20030152607A1 (en) * | 2002-02-13 | 2003-08-14 | Mault James R. | Caloric management system and method with voice recognition |
| US6607387B2 (en) | 2000-10-30 | 2003-08-19 | Healthetech, Inc. | Sensor system for diagnosing dental conditions |
| USD478660S1 (en) | 2002-07-01 | 2003-08-19 | Healthetech, Inc. | Disposable mask with sanitation insert for a respiratory analyzer |
| US20030163321A1 (en) * | 2000-06-16 | 2003-08-28 | Mault James R | Speech recognition capability for a personal digital assistant |
| US6612306B1 (en) | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| US6620106B2 (en) | 2000-09-29 | 2003-09-16 | Healthetech, Inc. | Indirect calorimetry system |
| US6629934B2 (en) | 2000-02-02 | 2003-10-07 | Healthetech, Inc. | Indirect calorimeter for medical applications |
| US20030208110A1 (en) * | 2000-05-25 | 2003-11-06 | Mault James R | Physiological monitoring using wrist-mounted device |
| US20030208133A1 (en) * | 2000-06-07 | 2003-11-06 | Mault James R | Breath ketone analyzer |
| US20030220579A1 (en) * | 2002-04-01 | 2003-11-27 | Mault James R. | System and method of determining an individualized drug administration protocol |
| US20030226695A1 (en) * | 2000-05-25 | 2003-12-11 | Mault James R. | Weight control method using physical activity based parameters |
| US6790178B1 (en) * | 1999-09-24 | 2004-09-14 | Healthetech, Inc. | Physiological monitor and associated computation, display and communication unit |
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1955
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Non-Patent Citations (1)
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Cited By (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4917108A (en) * | 1988-06-29 | 1990-04-17 | Mault James R | Oxygen consumption meter |
| US20010044588A1 (en) * | 1996-02-22 | 2001-11-22 | Mault James R. | Monitoring system |
| US5836300A (en) * | 1996-03-11 | 1998-11-17 | Mault; James R. | Metabolic gas exchange and noninvasive cardiac output monitor |
| US6135107A (en) * | 1996-03-11 | 2000-10-24 | Mault; James R. | Metabolic gas exchange and noninvasive cardiac output monitor |
| US6309360B1 (en) | 1997-03-17 | 2001-10-30 | James R. Mault | Respiratory calorimeter |
| US6645158B2 (en) | 1998-02-05 | 2003-11-11 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
| US6402698B1 (en) | 1998-02-05 | 2002-06-11 | James R. Mault | Metabolic calorimeter employing respiratory gas analysis |
| US6506608B2 (en) | 1998-08-03 | 2003-01-14 | Healthetech, Inc. | Method and apparatus for respiratory gas analysis employing measurement of expired gas mass |
| US6277645B1 (en) | 1998-08-03 | 2001-08-21 | James R. Mault | Method and apparatus for respiratory gas analysis employing measurement of expired gas mass |
| US6406435B1 (en) | 1998-11-17 | 2002-06-18 | James R. Mault | Method and apparatus for the non-invasive determination of cardiac output |
| US6517496B1 (en) | 1999-05-10 | 2003-02-11 | Healthetech, Inc. | Airway-based cardiac output monitor and methods for using same |
| US20030167016A1 (en) * | 1999-05-10 | 2003-09-04 | Mault James R. | Airway-based cardiac output monitor and methods for using same |
| US6468222B1 (en) | 1999-08-02 | 2002-10-22 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
| US6899683B2 (en) | 1999-08-02 | 2005-05-31 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
| US6955650B2 (en) | 1999-08-02 | 2005-10-18 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
| US20030065274A1 (en) * | 1999-08-02 | 2003-04-03 | Mault James R. | Method of respiratory gas analysis using a metabolic calorimeter |
| US20030065275A1 (en) * | 1999-08-02 | 2003-04-03 | Mault James R. | Metabolic calorimeter employing respiratory gas analysis |
| US6790178B1 (en) * | 1999-09-24 | 2004-09-14 | Healthetech, Inc. | Physiological monitor and associated computation, display and communication unit |
| US6478736B1 (en) | 1999-10-08 | 2002-11-12 | Healthetech, Inc. | Integrated calorie management system |
| US6612306B1 (en) | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| US6629934B2 (en) | 2000-02-02 | 2003-10-07 | Healthetech, Inc. | Indirect calorimeter for medical applications |
| US6482158B2 (en) | 2000-05-19 | 2002-11-19 | Healthetech, Inc. | System and method of ultrasonic mammography |
| US20030226695A1 (en) * | 2000-05-25 | 2003-12-11 | Mault James R. | Weight control method using physical activity based parameters |
| US20030208110A1 (en) * | 2000-05-25 | 2003-11-06 | Mault James R | Physiological monitoring using wrist-mounted device |
| US20030208133A1 (en) * | 2000-06-07 | 2003-11-06 | Mault James R | Breath ketone analyzer |
| US20030163321A1 (en) * | 2000-06-16 | 2003-08-28 | Mault James R | Speech recognition capability for a personal digital assistant |
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| US20020047867A1 (en) * | 2000-09-07 | 2002-04-25 | Mault James R | Image based diet logging |
| US6620106B2 (en) | 2000-09-29 | 2003-09-16 | Healthetech, Inc. | Indirect calorimetry system |
| US20020133378A1 (en) * | 2000-10-13 | 2002-09-19 | Mault James R. | System and method of integrated calorie management |
| US6607387B2 (en) | 2000-10-30 | 2003-08-19 | Healthetech, Inc. | Sensor system for diagnosing dental conditions |
| US20020055857A1 (en) * | 2000-10-31 | 2002-05-09 | Mault James R. | Method of assisting individuals in lifestyle control programs conducive to good health |
| US20020138213A1 (en) * | 2001-03-02 | 2002-09-26 | Mault James R. | System and method of metabolic rate measurement |
| US20030023181A1 (en) * | 2001-07-26 | 2003-01-30 | Mault James R. | Gas analyzer of the fluorescent-film type particularly useful for respiratory analysis |
| US20030130595A1 (en) * | 2001-08-13 | 2003-07-10 | Mault James R. | Health improvement systems and methods |
| US20030105407A1 (en) * | 2001-11-30 | 2003-06-05 | Pearce, Edwin M. | Disposable flow tube for respiratory gas analysis |
| US20030130567A1 (en) * | 2002-01-09 | 2003-07-10 | Mault James R. | Health-related devices and methods |
| US20030152607A1 (en) * | 2002-02-13 | 2003-08-14 | Mault James R. | Caloric management system and method with voice recognition |
| US20030220579A1 (en) * | 2002-04-01 | 2003-11-27 | Mault James R. | System and method of determining an individualized drug administration protocol |
| US7291114B2 (en) | 2002-04-01 | 2007-11-06 | Microlife Corporation | System and method of determining an individualized drug administration protocol |
| USD478660S1 (en) | 2002-07-01 | 2003-08-19 | Healthetech, Inc. | Disposable mask with sanitation insert for a respiratory analyzer |
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