US20170021156A1 - Safety drug handling device - Google Patents
Safety drug handling device Download PDFInfo
- Publication number
- US20170021156A1 US20170021156A1 US15/175,385 US201615175385A US2017021156A1 US 20170021156 A1 US20170021156 A1 US 20170021156A1 US 201615175385 A US201615175385 A US 201615175385A US 2017021156 A1 US2017021156 A1 US 2017021156A1
- Authority
- US
- United States
- Prior art keywords
- vial
- adaptor
- syringe
- receptacle
- port
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/1011—Locking means for securing connection; Additional tamper safeties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2072—Venting means for internal venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/22—Arrangements for transferring or mixing fluids, e.g. from vial to syringe with means for metering the amount of fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2017—Piercing means having three or more piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2034—Separating means having separation clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
- A61J1/2062—Connecting means having multiple connecting ports with directional valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
- A61M2005/1623—Details of air intake
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M2039/0009—Assemblies therefor designed for particular applications, e.g. contrast or saline injection, suction or irrigation
- A61M2039/0027—Assemblies therefor designed for particular applications, e.g. contrast or saline injection, suction or irrigation for mixing several substances from different containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M2039/0036—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use characterised by a septum having particular features, e.g. having venting channels or being made from antimicrobial or self-lubricating elastomer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1072—Tube connectors; Tube couplings with a septum present in the connector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1077—Adapters, e.g. couplings adapting a connector to one or several other connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/223—Multiway valves
Abstract
A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
Description
- The present application is related to and claims priority from the following pending patent applications, the disclosure of which is hereby incorporated by reference:
- U.S. Provisional Patent Application No. 60/516,613.
- The present invention relates to drug mixing systems generally.
- The following U.S. Patents and non-U.S. patent publications are believed to represent the current state of the art:
- U.S. Pat. Nos. 6,221,041; 6,715,520; 6,409,708; PCT US02/40596; WO 2004004806; WO 03086529; WO 9819724; WO 03/086530; WO 0035517 and WO 0211794.
- The present invention seeks to provide an improved drug mixing system, operative for use with a luer fitted hypodermic syringe, which is particularly useful in handling toxic drugs such as antineoplastic drugs.
- There is thus provided in accordance with a preferred embodiment of the present invention a drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one vial adaptor adapted for connection to a vial containing a drug and at least one syringe adaptor adapted to be attached to a syringe and to at least one of the at least one receptacle port adaptor and the at least one vial adaptor, the system being characterized in that at least one of the at least one receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
- There is also provided in accordance with another preferred embodiment of the present invention a drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one vial adaptor adapted for connection to a vial containing a drug and at least one syringe adaptor adapted to be attached to a syringe and to at least one of the at least one receptacle port adaptor and the at least one vial adaptor, the system being characterized in that the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial.
- Preferably, the drug mixing system also includes a membrane vent operative to vent at least one of the at least one receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor to the atmosphere. Additionally, the membrane vent includes a filter. Additionally or alternatively, the membrane vent includes a hydrophobic membrane.
- There is also provided in accordance with another preferred embodiment of the present invention a drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one vial adaptor adapted for connection to a vial containing a drug and at least one syringe adaptor adapted to be attached to a syringe and to at least one of the at least one receptacle port adaptor and the at least one vial adaptor, the system being characterized in that the at least one syringe adaptor is adapted to be brought into fluid communication and mechanically locked to at least one of the at least one receptacle port adaptor and the at least one vial adaptor in a single step.
- Preferably, at least one of the at least one vial adaptor, the at least one receptacle port adaptor and the at least one syringe adaptor are vented to the atmosphere without permitting potentially harmful contents of the vial to reach the atmosphere.
- Preferably, the drug mixing system also includes a stopcock connected to the at least one vial adaptor and to the at least one receptacle port adaptor.
- There is further provided in accordance with yet another preferred embodiment of the present invention a drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle and at least one vial adaptor adapted for connection to a vial containing a drug and connected to the at least one receptacle port adaptor, the system being characterized in that at least one of the at least one receptacle port adaptor and the at least one vial adaptor is vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial.
- There is even further provided in accordance with still another preferred embodiment of the present invention a drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle and at least one vial adaptor adapted for connection to a vial containing a drug and connected to the at least one receptacle port adaptor, the at least one vial adaptor including a venting and sealing element, operative to allow air into the drug mixing system and adapted to prevent air from escaping from the drug mixing system.
- Preferably, the venting and sealing element includes a hydrophobic membrane and a narrow bore.
- Preferably, the narrow bore is irreversibly filled with liquid upon flow of liquid from the fluid receptacle to the vial, thus preventing air from escaping.
- Alternatively or additionally, the receptacle port adaptor includes an elastomer covered needle and the receptacle port adaptor and the vial adaptor are integrally formed. Alternatively, the receptacle port adaptor includes an elastomer covered needle and the receptacle port adaptor, the syringe adaptor and the vial adaptor are integrally formed.
- Preferably, the at least one vial adaptor also includes a protective vial housing operative to prevent release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form in the event of breakage of the vial.
- In another preferred embodiment, the fluid receptacle includes a spike port and the at least one receptacle port adaptor includes a spike port adaptor. Additionally or alternatively, the fluid receptacle includes a needle port and the at least one receptacle port adaptor includes a needle port adaptor. Additionally, the needle port adaptor includes a needle, the needle being protected by a needle protector. Preferably, the needle protector includes a latex needle cover.
- Preferably, the drug mixing system also includes a vial head adaptor adapted for connection between the vial adaptor and the vial.
- In another preferred embodiment, the at least one receptacle port adaptor and the fluid receptacle are adapted to be connected to an intravenous cannula on a patient via an intravenous infusion set.
- Preferably, the at least one syringe adaptor and the syringe are adapted to be connected to an intravenous cannula on a patient via an intravenous infusion set using an infusion set adaptor. Additionally or alternatively, the syringe adaptor is covered by a syringe cover element.
- There is yet further provided in accordance with another preferred embodiment of the present invention a drug mixing system including at least one drug mixing element including atmospheric venting functionality, characterized in that it prevents potentially harmful drug material from being released to the atmosphere via the venting functionality, the potentially harmful drug material including at least one of solid, liquid, gas and aerosol.
- There is even further provided in accordance with yet another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, inserting a receptacle port adaptor into a port in a receptacle containing a fluid, attaching the syringe adaptor, having the syringe attached thereto, to the receptacle port adaptor, retracting the plunger, thereby at least partially filling the syringe with fluid drawn from the receptacle in a manner which ensures that the fluid remains sterile and that a user is not exposed to the fluid, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, pushing the plunger, thus injecting the fluid contained in the syringe into the drug containing vial, thereby producing a drug solution in the vial and retracting the plunger, thus drawing at least part of the contents of the vial into the syringe, wherein at least one of the receptacle port adaptor, the syringe adaptor and the vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
- There is still further provided in accordance with yet another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, inserting a receptacle port adaptor into a port in a receptacle containing a fluid, attaching the syringe adaptor, having the syringe attached thereto, to the receptacle port adaptor, retracting the plunger, thereby at least partially filling the syringe with fluid drawn from the receptacle in a manner which ensures that the fluid remains sterile and that a user is not exposed to the fluid, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, pushing the plunger, thus injecting the fluid contained in the syringe into the drug containing vial, thereby producing a drug solution in the vial and retracting the plunger, thus drawing at least part of the contents of the vial into the syringe, wherein the syringe adaptor is adapted to be brought into fluid communication and mechanically locked to at least one of the receptacle port adaptor and the vial adaptor in a single step.
- There is yet further provided in accordance with another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, inserting a receptacle port adaptor into a port in a receptacle containing a fluid, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, retracting the plunger, thus drawing at least part of the contents of the vial into the syringe, connecting the syringe adaptor having the syringe attached thereto, to the receptacle port adaptor and pushing the plunger, thus injecting the at least part of the contents of the vial into the receptacle, wherein at least one of the receptacle port adaptor, the syringe adaptor and the vial adaptor is vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
- There is still further provided in accordance with yet another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, inserting a receptacle port adaptor into a port in a receptacle containing a fluid, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, retracting the plunger, thus drawing at least part of the contents of the vial into the syringe, connecting the syringe adaptor having the syringe attached thereto, to the receptacle port adaptor and pushing the plunger, thus injecting the at least part of the contents of the vial into the receptacle, wherein the syringe adaptor is adapted to be brought into fluid communication and mechanically locked to at least one of the receptacle port adaptor and the vial adaptor in a single step.
- There is even further provided in accordance with another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, retracting the plunger, thus drawing at least part of the contents of the, vial into the syringe and pushing the plunger, thus injecting the at least part of the contents of the vial into an infusion line, wherein at least one of the receptacle port adaptor, the syringe adaptor and the vial adaptor is vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
- There is still further provided in accordance with yet another preferred embodiment of the present invention a drug mixing method including attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor, connecting the syringe adaptor having the syringe attached thereto, to a vial adaptor assembly, having a drug containing vial attached thereto, retracting the plunger, thus drawing at least part of the contents of the vial into the syringe and pushing the plunger, thus injecting the at least part of the contents of the vial into an infusion line, wherein the syringe adaptor is adapted to be brought into fluid communication and mechanically locked to at least one of the receptacle port adaptor and the vial adaptor in a single step.
- Preferably, the connecting the syringe adaptor also includes disconnecting the syringe adaptor from the receptacle adaptor prior to the connecting. Preferably, the connecting the syringe adaptor having the syringe attached thereto to the receptacle port adaptor also includes disconnecting the syringe adaptor from the vial adaptor prior to the connecting.
- Additionally or alternatively, the connecting the syringe adaptor includes connecting the drug containing vial to a vial head adaptor and connecting the drug containing vial having the vial head adaptor attached thereto to the vial adaptor assembly, prior to the connecting the syringe to the vial adaptor assembly. Alternatively or additionally, the drug mixing method also includes attaching the syringe adaptor, having the syringe containing at least part of the drug solution attached thereto, to the receptacle port adaptor and injecting contents of the syringe into the receptacle.
- There is still further provided in accordance with still another preferred embodiment of the present invention a drug mixing method including inserting a receptacle port adaptor into a port in a receptacle containing a fluid, connecting a drug containing vial to the receptacle port adaptor, transferring at least a portion of the fluid from the receptacle to the drug containing vial, thereby producing a drug solution in the vial and subsequently transferring the drug solution from the vial to the receptacle.
- Preferably, the connecting the drug containing vial includes connecting the drug containing vial to a vial head adaptor prior to the connecting the drug containing vial. Additionally or alternatively, the receptacle port adaptor includes at least one of a spike port adaptor and a needle port adaptor.
- There is yet further provided in accordance with another preferred embodiment of the present invention a vial adaptor adapted for connection to a vial containing a drug and adapted for connection to other elements of a drug mixing system, the vial adaptor including a spike adapted for penetrating the vial, a mechanical lock for locking the vial adaptor to the vial once the spike penetrates the vial and an element operative to vent the interior of the vial to the atmosphere without permitting potentially harmful contents of the vial to reach the atmosphere.
- Preferably, the vial adaptor also includes a membrane vent operative to vent the vial adaptor to the atmosphere. Additionally, the membrane vent includes a filter. Alternatively or additionally, the membrane vent includes a hydrophobic membrane.
- Preferably, the vial adaptor also includes a septum equipped syringe port. Additionally or alternatively, the vial adaptor includes at least one locking element, operative to irreversibly lock the vial adaptor to the vial. Preferably, the at least one locking element includes at least one radially extending portion and at least one transversely extending portion.
- There is further provided in accordance with yet another preferred embodiment of the present invention a vial adaptor adapted for connection to a vial containing a drug and being adapted for connection to other elements of a drug mixing system, the vial adaptor including at least one locking element, operative to irreversibly lock the vial adaptor to the vial.
- Preferably, the at least one locking element includes at least one radially extending portion and at least one transversely extending portion.
- There is still further provided in accordance with another preferred embodiment of the present invention a vial adaptor adapted for connection to a vial containing a drug and being adapted for connection to a fluid transfer device, the vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.
- Preferably, the vial adaptor also includes a membrane vent operative to vent the vial adaptor to the atmosphere. Additionally, the membrane vent includes a filter. Alternatively or additionally, the membrane vent includes a hydrophobic membrane.
- There is yet further provided in accordance with still another preferred embodiment of the present invention a syringe adaptor adapted for connection to a syringe and adapted for connection to at least one other element of a drug mixing system, the syringe adaptor including a septa housing, at least two septa enclosed in the septa housing defining a space therebetween and a needle, including a tip located in the space when the syringe adaptor is not connected to the at least one other element.
- Preferably, the septa housing is movable relative to the needle, thereby to expose the tip. Additionally or alternatively, at least a portion of the needle is protected by a needle protector. Additionally, the needle protector includes an elastomeric tubing element.
- There is still further provided in accordance with yet a further preferred embodiment of the present invention a vial head adaptor for use in connecting a vial with a first head circumference to a vial adaptor adapted for use with a vial with a second head circumference, the second head circumference being greater than the first head circumference, the vial head adaptor including at least one locking element.
- Preferably, the at least one locking element includes four locking elements arranged generally at right angles to each other. Additionally, the at least one locking element includes a locking tooth.
- There is even further provided in accordance with still another preferred embodiment of the present invention a receptacle port adaptor for use in a drug mixing system including a housing, a needle located within the housing and adapted to be inserted into a port of a fluid receptacle, a septum located in the housing and a locking mechanism to fix the receptacle port adaptor to the port.
- Preferably, the needle is protected by a needle protector. Additionally, the needle protector includes a latex needle cover. Alternatively or additionally, the needle moves between a protected position and a piercing position.
- There is also provided in accordance with yet another preferred embodiment of the present invention a protective vial housing for use with a drug mixing system including a fluid flow passageway adapted to connect a vial containing a drug to the drug mixing system, the protective vial housing being operative to prevent release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form in the event of breakage of the vial.
- The present invention will be understood and appreciated more fully from the following detailed description, taken in conjunction with the drawings in which:
-
FIGS. 1A, 1B, 1C, 1D, 1E, 1F, 1G, 1H, 1I, 1J, 1K, 1L and 1M are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with a preferred embodiment of the present invention; -
FIG. 2 is a simplified pictorial illustration of a vial head adaptor element which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIG. 3 is a sectional illustration taken along section lines III-III inFIG. 2 ; -
FIG. 4 is a simplified exploded view illustration of a vial adaptor assembly which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIG. 5 is a simplified assembled pictorial illustration of the vial adaptor assembly ofFIG. 4 ; -
FIGS. 6A and 6B are sectional illustrations taken along respective section lines VIA-VIA and VIB-VIB inFIG. 5 ; -
FIG. 7 is a simplified exploded view illustration of a syringe adaptor element which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIG. 8 is a simplified assembled pictorial illustration of the syringe adaptor element ofFIG. 7 ; -
FIGS. 9A and 9B are sectional illustrations taken along respective section lines IXA-IXA and IXA-IXB inFIG. 8 ; -
FIG. 9C is a sectional illustration of an alternative embodiment of the syringe adaptor element ofFIG. 8 , taken along section lines IXA-IXA inFIG. 8 . -
FIG. 10 is a simplified pictorial illustration of a spike port adaptor element which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIGS. 11A and 11B are sectional illustrations taken along section lines XI-XI inFIG. 10 , of two different inner structures of the spike port adaptor element; -
FIGS. 12A and 12B are simplified pictorial illustrations of a needle port adaptor element which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIGS. 13A and 13B are sectional illustrations taken along respective section lines XIIIA-XIIIA and XIIIB-XIIIB inFIG. 12A ; -
FIG. 14 is a simplified pictorial illustration of a syringe protection cover which fours part of the drug mixing system ofFIGS. 1A-1M ; -
FIG. 15 is a sectional illustration taken along section lines XV-XV inFIG. 14 ; -
FIG. 16 is a simplified pictorial illustration of an injection set adaptor element which forms part of the drug mixing system ofFIGS. 1A-1M ; -
FIG. 17 is a sectional illustration taken along section lines XVII-XVII inFIG. 16 ; -
FIGS. 18A and 18B are, respectively, a simplified planar illustration and a simplified sectional illustration of the drug mixing system ofFIG. 1A during attachment of the vial adaptor, the sectional illustration being taken along lines XVIIB-XVIIIB inFIG. 18A ; -
FIGS. 19A and 19B are, respectively, a top view simplified planar illustration and a simplified sectional illustration of the drug mixing system ofFIG. 1C during attachment of the syringe adaptor, the sectional illustration being taken along lines XIXB-XIXB inFIG. 19A ; -
FIGS. 19C and 19D are respectively, a side view simplified planar illustration and a simplified sectional illustration of the drug mixing system ofFIG. 1C during attachment of the syringe adaptor, the sectional illustration being taken along lines XIXD-XIXD inFIG. 19C ; -
FIG. 20 is a partially pictorial partially sectional illustration of the drug mixing system ofFIG. 1D during attachment of the spike port adaptor element; -
FIG. 21 is a partially pictorial partially sectional illustration of the drug mixing system ofFIG. 1D during attachment of the needle port adaptor element; -
FIG. 22 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 20 prior to syringe attachment; -
FIG. 23 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 20 following syringe attachment; -
FIG. 24 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 21 prior to syringe attachment; -
FIG. 25 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 21 following syringe attachment; -
FIG. 26 is a sectional illustration of the drug mixing system ofFIG. 1G prior to drug dilution; -
FIG. 27 is a sectional illustration of the drug mixing system ofFIG. 1H following drug dilution; -
FIG. 28 is a sectional illustration of the drug mixing system ofFIGS. 1K and 1L in a protected, ready for delivery state; -
FIG. 29 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1M and 28 when ready for injection; -
FIG. 30 is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1M and 20 when ready for injection; -
FIGS. 31A, 31B, 31C, 31D, 31E, 31F, 31G, 31H, 311, 31J, 31K and 31L are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with another preferred embodiment of the present invention; -
FIG. 32 is a simplified pictorial illustration of a vial head adaptor element which forms part of the drug mixing system ofFIGS. 31A-31L ; -
FIG. 33 is a sectional illustration taken along section lines XXXIII-XXXIII inFIG. 32 ; -
FIG. 34 is a simplified pictorial illustration of a spike port adaptor element which forms part of the drug mixing system ofFIGS. 31A-31L ; -
FIG. 35 is a sectional illustration taken along section lines XXXV-XXXV inFIG. 34 ; -
FIG. 36 is a simplified exploded view illustration of an adaptor assembly which forms part of the drug mixing system ofFIGS. 31A-31L ; -
FIG. 37 is a simplified pictorial illustration of a stopcock element which forms part of the adaptor assembly ofFIG. 36 ; -
FIGS. 38A and 38B are sectional illustrations taken along respective section lines XXXVIIIA-XXXVIIIA and XXXVIIB-XXXVIIIB inFIG. 37 ; -
FIG. 39 is a simplified pictorial illustration of a receptacle adaptor subassembly which forms part of the adaptor assembly ofFIG. 36 ; -
FIGS. 40A and 40B are sectional illustrations taken along respective section lines XLA-XLA and XLB-XLB inFIG. 39 ; -
FIG. 41 is a simplified pictorial illustration of a vial adaptor subassembly which forms part of the adaptor assembly ofFIG. 36 ; -
FIGS. 42A and 42B are sectional illustrations taken along respective section lines XLIIA-XLIIA and XLIIB-XLIIB inFIG. 41 ; -
FIGS. 43A and 43B are simplified pictorial illustrations of a housing element which forms part of the adaptor assembly ofFIG. 36 in closed and open orientations, respectively; -
FIG. 44 is a simplified assembled pictorial illustration of the adaptor assembly ofFIG. 36 ; -
FIGS. 45A and 45B are sectional illustrations taken along respective section lines XVA-XVA and XVB-XVB inFIG. 44 ; -
FIG. 46 is a sectional illustration of the drug mixing system ofFIG. 31C during attachment of a syringe to the adaptor assembly ofFIGS. 44-45B ; -
FIG. 47 is a sectional illustration of the drug mixing system ofFIG. 31D during attachment of the receptacle adaptor element ofFIG. 31B to the adaptor assembly ofFIG. 46 ; -
FIG. 48 is a sectional illustration of the drug mixing system ofFIG. 31E during attachment of a vial to the adaptor assembly ofFIG. 47 ; -
FIG. 49 is a sectional illustration of the drug mixing system ofFIGS. 31F and 48 during fluid drawing from a receptacle; -
FIG. 50 is a sectional illustration of the drug mixing system ofFIGS. 31G and 48 during fluid injection into a vial; -
FIG. 51 is a sectional illustration of the drug mixing system ofFIGS. 31I and 48 during fluid drawing from a vial; -
FIG. 52 is a sectional illustration of the drug mixing system ofFIG. 31J and 48 during fluid injection into a receptacle; -
FIG. 53 is a sectional illustration of the drug mixing system ofFIG. 31L when ready for storage; -
FIGS. 54A, 54B, 54C, 54D, 54E, 54F, 54G and 54H are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with yet another preferred embodiment of the present invention; -
FIG. 55 is a simplified pictorial illustration of a vial head adaptor element which fauns part of the drug mixing system ofFIGS. 54A-54H ; -
FIG. 56 is a sectional illustration taken along section lines LVI-LVI inFIG. 55 ; -
FIG. 57 is a simplified pictorial illustration of a spike port adaptor element which forms part of the drug mixing system ofFIGS. 54A-54H ; -
FIG. 58 is a sectional illustration taken along section lines LVIII-LVIII inFIG. 57 ; -
FIG. 59 is a simplified exploded view illustration of an adaptor assembly which forms part of the drug mixing system ofFIGS. 54A-54H ; -
FIG. 60 is a simplified pictorial illustration of ad vial adaptor subassembly which forms part of the adaptor assembly ofFIG. 59 ; -
FIGS. 61A and 61B are sectional illustrations taken along respective section lines LXIA-LXIA and LXIB-LXIB inFIG. 60 ; -
FIG. 62 is a simplified pictorial illustration of a receptacle adaptor subassembly which forms part of the adaptor assembly ofFIG. 59 ; -
FIGS. 63A and 63B are sectional illustrations taken along respective section lines LXIIIA-LXIIIA and LXIIIB-LXIIIB inFIG. 62 ; -
FIGS. 64A and 64B are simplified pictorial illustrations of a housing element which forms part of the adaptor assembly ofFIG. 59 in closed and open orientations, respectively; -
FIG. 65 is a simplified assembled pictorial illustration of the adaptor assembly ofFIG. 59 ; -
FIGS. 66A and 66B are sectional illustrations taken along respective section lines LXVIA-LXVIA and LXVIB-LXVIB inFIG. 65 ; -
FIGS. 67A and 67B are sectional illustrations of the drug mixing system ofFIG. 54C during attachment of a vial to the adaptor assembly ofFIG. 65 ; -
FIG. 68 is a sectional illustration of the drug mixing system ofFIG. 54D-54G during attachment of the receptacle port adaptor element ofFIG. 54B to the adaptor assembly ofFIG. 67 ; -
FIG. 69 is a sectional illustration of the drug mixing system ofFIGS. 54H and 68 during disconnection of the receptacle port adaptor element ofFIG. 54B from the adaptor assembly ofFIG. 67 ; -
FIG. 70 is an exploded view illustration of a drug mixing system which is constructed and operative in accordance with a further preferred embodiment of the present invention; -
FIG. 71 is a simplified pictorial illustration of a vial support element which forms part of the drug mixing system ofFIG. 70 ; -
FIGS. 72A and 72B are, respectively, a sectional illustration and a pictorial sectional illustration taken along section lines LXXII-LXXII inFIG. 71 ; -
FIG. 73 is a simplified pictorial illustration of the vial support element ofFIG. 71 , when containing a vial; -
FIG. 74 is a sectional illustration taken along section lines LXXIV-LXXIV inFIG. 73 ; -
FIGS. 75A and 75B are simplified pictorial illustrations of a vial puncturing cover element which forms part of the vial adaptor subassembly ofFIG. 70 ; -
FIG. 76 is a sectional illustration taken along section lines LXXVI-LXXVI inFIG. 75A ; -
FIG. 77 is a simplified assembled pictorial illustration of the vial adaptor subassembly ofFIG. 70 ; -
FIG. 78 is a sectional illustration taken along section lines LXXVIII-LXXVIII inFIG. 77 ; -
FIG. 79 is a pictorial illustration of the vial adaptor assembly ofFIG. 77 when assembled to an adaptor assembly in accordance with a preferred embodiment of the present invention; -
FIG. 80 is a sectional illustration taken along section lines LXXX-LXXX inFIG. 79 ; -
FIG. 81 is a pictorial illustration taken of the vial adaptor assembly and adaptor assembly ofFIG. 79 when connected to a receptacle port adaptor element and a receptacle in accordance with a preferred embodiment of the present invention; -
FIG. 82 is a sectional illustration taken along section lines LXXXII-LXXXII inFIG. 81 ; -
FIG. 83 is an exploded view illustration of a drug mixing system which is constructed and operative in accordance with a still further preferred embodiment of the present invention; -
FIG. 84 is a simplified pictorial illustration of a receptacle adaptor housing assembly which forms part of the drug mixing system ofFIG. 83 ; -
FIGS. 85A and 85B are sectional illustrations taken along section lines LXXXVA-LXXXVA and LXXXVB-LXXXVB inFIG. 84 ; -
FIG. 86 is a simplified pictorial illustration of a receptacle adaptor needle element which forms part of the drug mixing system ofFIG. 83 ;FIGS. 87A and 87B are sectional illustrations taken along section lines LXXXVIIA-LXXXVIIA and LXXXVIIB-LXXXVIIB inFIG. 86 ; -
FIG. 88 is a simplified assembled pictorial illustration of the receptacle adaptor subassembly ofFIG. 83 ; -
FIGS. 89A and 89B are sectional illustrations taken along section lines LXXXIXA-LXXXIXA and LXXXIXB-LXXXIXB inFIG. 88 ; -
FIG. 90 is a pictorial illustration of the receptacle adaptor subassembly ofFIG. 88 when assembled to a vial adaptor subassembly in accordance with a preferred embodiment of the present invention, prior to connection of a needle to a receptacle port element; -
FIG. 91 is a sectional illustration taken along section lines XCI-XCI inFIG. 90 ; -
FIG. 92 is a pictorial illustration of the receptacle adaptor subassembly ofFIG. 88 when assembled to a vial adaptor subassembly, following connection of a needle to a receptacle port element; and -
FIG. 93 is a sectional illustration taken along section lines XCIII-XCIII inFIG. 92 . - Reference is now made to
FIGS. 1A, 1B, 1C, 1D, 1E, 1F, 1G, 1H, 1I, 1J, 1K, 1L and 1M which are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with a preferred embodiment of the present invention. - As seen in
FIG. 1A , aconventional vial 10, including atop portion 12 and aneck portion 13, is pushed into engagement with avial adaptor assembly 30 which is described hereinbelow with reference toFIGS. 4-6B .Top portion 12 ofvial 10 preferably has aseptum 31 sealingly seated therein.FIGS. 18A-18B show a sectional view of the drug mixing system at this stage: - Alternatively, if a
small vial 32 is used,small vial 32 is pushed into engagement with a vialhead adaptor element 34 which is described hereinbelow with reference toFIGS. 2-3 as shown inFIG. 1B , and is then pushed into engagement withvial adaptor assembly 30. Thevials - As shown in
FIG. 1C , a luer fittedhypodermic syringe 40 having aplunger 42 and aluer tip 44 is attached to asyringe adaptor element 50 which is described hereinbelow with reference toFIGS. 7-9B .FIGS. 19A-19D show planar and sectional views of the drug mixing system at this stage. -
FIG. 1D shows a spikeport adaptor element 60, as described hereinbelow with reference toFIGS. 10-11 , being inserted into aspike port 61 in areceptacle 62 containing a fluid.FIG. 20 shows a partially pictorial partially sectional view of the drug mixing system at this stage. Typically,receptacle 62 comprises a bag, and the fluid contained therein is sterile saline solution, water, or any other suitable sterile solution or pure fluid. - Alternatively, a needle
port adaptor element 70, as described hereinbelow with reference toFIGS. 12A-13B , is inserted into aneedle port 64 inreceptacle 62.FIG. 21 shows a sectional view of the drug mixing system at this stage. It will be appreciated by persons skilled in the art that the assembly steps shown inFIGS. 1B-1D may be performed in any suitable sequence. - As seen in
FIG. 1E ,syringe adaptor element 50, havingsyringe 40 attached thereto (FIG. 1C ), is connected to a connection port in either of spikeport adaptor element 60 or needleport adaptor element 70 ofFIG. 1D .FIGS. 22-23 and 24-25 , respectively, show partially pictorial partially sectional views of the two alternate orientations of the drug mixing system at this stage. - Typically,
plunger 42 ofsyringe 40 is fully pushed inward intosyringe 40 beforesyringe adaptor element 50 is connected to either of spikeport adaptor element 60 and needleport adaptor element 70. - As seen in
FIG. 1F , a user retractsplunger 42 in either of the operative orientations ofFIG. 1E , thus at least partially fillingsyringe 40 with fluid drawn fromreceptacle 62. The fluid flows through the spikeport adaptor element 60 or through the needleport adaptor element 70 directly intosyringe 40. This flow of fluid ensures that the fluid remains sterile, and that the user is not exposed to the fluid. Subsequently, thesyringe 40 andsyringe adaptor element 50 are disconnected from the spikeport adaptor element 60 or the needleport adaptor element 70. The drug mixing system of the present invention also ensures that the user is not exposed to the fluid during disconnection thereof, as explained further hereinbelow. - The user then connects
syringe adaptor element 50, which is attached tosyringe 40, to thevial adaptor assembly 30 having thevial 10 attached thereto, as shown inFIG. 1G .FIG. 26 shows a sectional view of the drug mixing system at this stage. - When the
syringe 40 andvial 10 are connected and fluid can flow therebetween, the user pushesplunger 42 inward, with the vial positioned upright, thus injecting the fluid contained insyringe 40 intovial 10 and dissolving the drug contained therein.FIG. 27 shows a sectional view of the drug mixing system at this stage. As seen inFIG. 1H , the user then shakes the drug mixing system ofFIG. 1G to ensure that the drug invial 10 is fully dissolved and that the resulting solution is homogenous. - It is appreciated that when
vial 10 contains a drug in a pre-dissolved form, the steps described hereinabove with reference toFIGS. 1E-1H may be obviated. As seen inFIG. 1I , the user turns the drug mixing system upside clown and retractsplunger 42, thus drawing at least part of the solution from thevial 10 intosyringe 40. Subsequently,syringe 40 andsyringe adaptor element 50 are disconnected fromvial 10 andvial adaptor assembly 30, as shown inFIG. 1J . At this stage, if some of the drug solution is left invial 10,vial 10 andvial adaptor assembly 30, joined thereto, may be stored in a suitable facility for further use. - At a next stage, the drug solution contained in
syringe 40 is prepared for delivery to a hospital ward for infusion into a patient. As shown inFIG. 1K ,syringe 40 containing the drug solution is connected to spikeport adaptor element 60 for transferring the drug intoreceptacle 62. Alternatively,syringe 40 may be connected to needleport adaptor element 70. - As a further alternative, the user may place a
syringe protection cover 80, which is described hereinbelow with reference toFIGS. 14-15 , onto thesyringe adaptor element 50 which is attached tosyringe 40, prior to delivering it to a hospital ward. - As seen in
FIG. 1L , the user pushesplunger 42 ofsyringe 40 inward, thus injecting the drug solution intoreceptacle 62 and further diluting it prior to infusion into a patient. Alternatively,syringe 40 may be covered by thesyringe protection cover 80 and is ready for delivery to the appropriate hospital ward.FIG. 28 is a sectional view of the drug mixing system at this stage. - As seen in
FIG. 1M , thereceptacle 62 and spikeport adaptor element 60 are connected via a standard infusion set 92 such as model IAS which is commercially available from Teva Medical Ltd. of Ashdod, Israel, to a patient's intravenous cannula. The connection to the spikeport adaptor element 60 is performed after the removal of a connection element which is placed at the end of the spikeport adaptor element 60.FIG. 30 is a sectional view of the drug mixing system at this stage. - Alternatively, the
syringe 40 andsyringe adaptor element 50 may be connected via an infusion setadaptor element 90, which is described hereinbelow with reference toFIGS. 16-17 , to an infusion set 92 including aport 93 and anintravenous cannula 94 which is placed at the injection site. Beforesyringe adaptor element 50 is attached to the infusion setadaptor element 90, thesyringe protection cover 80 is removed from the end of thesyringe adaptor element 50.FIG. 29 shows a partially pictorial partially sectional view of the drug mixing system at this stage. - The structure of elements of the drug mixing system of
FIGS. 1A-1M is described hereinbelow with reference toFIGS. 2-17 . - Reference is now made to
FIG. 2 , which is a simplified pictorial illustration of a vialhead adaptor element 34 which forms part of the drug mixing system ofFIGS. 1A-1M , and toFIG. 3 , which is a sectional illustration taken along section lines III-III inFIG. 2 . - As seen in
FIG. 2 , vialhead adaptor element 34 is preferably a side-to-side symmetric integrally formed element, which is preferably injection molded of plastic. - Vial head adaptor element 20 preferably includes a generally cylindrical
main body portion 200 and has acentral axis 201. An innercylindrical surface 202 ofmain body portion 200 preferably has fourarms 204 extending therefrom, eacharm 204 being arranged at generally right angles with respect to its neighboring arms. - Each of
arms 204 terminates at an upper end thereof, in the sense ofFIG. 1B , in an inwardly facing generallytriangular tooth 206 having a forwardly facinginclined surface 208 and a bottom-facingengagement surface 210 extending generally perpendicular to aim 204. - At bottom surface of vial
head adaptor element 34, there are formed four inwardly protrudingsurfaces 212, extending generally perpendicular toinner surface 202 ofmain body portion 200. Each of neighboringsurfaces 212 is preferably arranged at a generally right angle with respect to its neighboringsurfaces 212.Surfaces 212 andarms 204 are rotationally offset from one another aboutaxis 201. - Reference is now made to
FIG. 4 , which is a simplified exploded view illustration of a preferredvial adaptor assembly 30 which forms part of the drug mixing system ofFIGS. 1A-1M , toFIG. 5 , which is a simplified assembled pictorial illustration of thevial adaptor assembly 30, and toFIGS. 6A and 6B , which are sectional illustrations taken along respective section lines VIA-VIA and VIB-VIB inFIG. 5 . - As seen in
FIGS. 4-6B ,vial adaptor assembly 30 comprises amain body element 302 arranged generally about anaxis 303.Main body element 302 is preferably integrally formed and preferably injection molded of plastic. -
Main body element 302 is preferably side-to-side symmetric aboutaxis 303, and preferably includes arear portion 304, which is generally cylindrical and terminates in aforward wall 306.Rear portion 304 comprises aforward base section 308, rearward of which are preferably foisted fourtabs 310 each having arectangular window 312. Rearward ofrectangular windows 312 and on aninner surface 314 of each oftabs 310 there are preferably formed two radially extending inwardly facingprotrusions 316 each having an inclined surface.Protrusions 316 preferably terminate at a forward end thereof in an inwardly facing transversely extendingprotrusion 318. Rearward ofprotrusions 316, each oftabs 310 preferably includes an outwardlytapered portion 320. - A hollow
vial puncturing spike 322 extends rearwardly from arearward surface 324 offorward wall 306, and is surrounded bybase section 308 and bytabs 310.Rearward surface 324 additionally includes a circularcylindrical protrusion 325, surrounding puncturingspike 322. Two radially extendingbores vial puncturing spike 322. - Forward of
forward wall 306 ofrear portion 304 there is formed anintermediate portion 328 which is generally rectangular, and includes axial hollowtubular portion 330 which is in fluid flow engagement withbore 327 ofvial puncturing spike 322. - At a top surface of
intermediate portion 328 and slightly recessed with respect thereto there is formed a plasticmembrane support surface 332, having formed thereon a plurality of generally evenly distributedspherical protrusions 334, which are adapted to support ahydrophobic membrane 336 and prevent it from excessive inflation and from cracking.Membrane 336 is adapted to allow free passage of air into themain body element 302, but to prevent passage therethrough of liquid and air-borne particles, microorganisms and aerosol. Apreferred membrane 336 is Model Versapor R 0.2 Micron which is commercially available from Pall Corporation of New York, U.S.A.Membrane 336 is in fluid flow engagement withvial puncturing spike 322 viabore 326 and via arecess 337 formed inintermediate portion 328. - A
rim 338 surroundingsupport surface 332 is adapted to support an optionalcarbon cloth filter 340 and maintain it in a raised position above and spaced frommembrane 336.Carbon cloth filter 340 is adapted to prevent toxic vapors from escaping frommain body element 302, thus protecting users. A preferredcarbon cloth filter 340 is Model No. Zorflex EMI, which is commercially available from Charcoal Cloth International Ltd. of Houghton-le-Spring, England. -
Intermediate portion 328 terminates at a forward end thereof in a generallycircular wall 342. Forward ofcircular wall 342 there is formed ahollow neck portion 344, which is in fluid flow engagement with hollowtubular portion 330 and with hollowvial puncturing spike 322.Hollow neck portion 344 terminates at a forward end thereof in a generallycircular wall surface 346. - Forward of
neck portion 344 there is formed a forward facingportion 348, which is adapted to sealingly accommodate a generallycircular septum 350 on aseat 352 which is located at a forward end ofportion 348. Forward facingportion 348 defines acentral bore 354 which communicates betweentubular portion 330 andseptum 350. -
Vial adaptor assembly 30 preferably additionally includes acovering element 360 which supports and coversmembrane 336 andcarbon filter 340. Coveringelement 360 is a generally cylindrical, generally side-to-side symmetric, element and is preferably formed with acentral opening 362 at a forward end thereof through whichforward portion 348 extends. - A pair of outer side surfaces 364 of covering
element 360 are each formed withribbed grip regions 366. An innertop surface 368 of coveringelement 360 is preferably flat, and is adapted to support the top surfaces ofmembrane 336 andcarbon filter 340 and to prevent excessive inflation and cracking thereof. - It is appreciated that the functionalities of
membrane 336 andcarbon cloth filter 340, to allow free passage of air into the drug mixing system while preventing passage thereinto of liquid and air-borne particles, microorganisms and aerosol and preventing toxic vapors from escaping from the drug mixing system, may be incorporated, using similar elements, into any ofsyringe adaptor element 50, spikeport adaptor element 60 and needleport adaptor element 70. - Reference is now made to
FIG. 7 , which is a simplified exploded view illustration ofsyringe adaptor element 50 which forms part of the drug mixing system ofFIGS. 1A-1M , toFIG. 8 , which is a simplified assembled pictorial illustration ofsyringe adaptor element 50 and toFIGS. 9A, 9B and 9C , which are sectional illustrations taken along respective section lines IXA-IXA and IXB-IXB inFIG. 8 . - As seen with particular clarity in
FIG. 7 ,syringe adaptor element 50 comprises ahousing element 500, which has seated therein aforward septum 502 and arearward septum 504. -
Housing element 500 is preferably an integrally formed cylindrical hollow element made of plastic and is preferably side-to-side, top-to-bottom and forward-rearward symmetrical. - Preferably, a
forward portion 506 ofhousing element 500 includes aseat 508 forforward septum 502, and arear portion 510 of the housing element includes aseat 512 forrearward septum 504. Anintermediate portion 514 ofhousing element 500 preferably includes on a top and a bottom surface thereof generally rectangular outwardly facingprotrusions 516. -
Septa circular portion 518 with a partiallyspherical protrusion 520 at one side thereof. - Surrounding
housing element 500 there is formed abody 522, which defines amain body portion 523, which is generally cylindrical, preferably side-to-side and top-to-bottom symmetrical, and preferably formed of plastic, and side surfaces 524. Extending from a forward portion of each of side surfaces 524 is an outwardlyprotruding arm 526, defining at an inner facing forward end thereof a generallytriangular tooth 527 having a transversely extending rearward facingsurface 528 which is adapted to engage a forward facing surface ofintermediate portion 514 ofhousing element 500. - Rearward of each of
arms 526 there is formed a generallyrectangular aperture 529. Adjacent arearward portion 530 ofhousing element 500 there is formed acircumferential protrusion 532, forward of which is formed an additionalcircumferential protrusion 534, having a slightly larger outer circumference than that ofprotrusion 532. - A
compression spring 536 is seated withinhousing element 500, on ashoulder 538 located betweenintermediate portion 514 andrear portion 510 ofhousing element 500. - A generally cylindrical
rear sealing element 540 is located rearward ofhousing element 500.Rear sealing element 540 is preferably side to side symmetric, and is typically formed of plastic. -
Rear sealing element 540 preferably defines aforward cowl 542 terminating at a rearward end thereof in a generallycircular wall portion 544.Forward cowl 542 preferably includes acircumferential recess 546, which is adapted to engagecircumferential protrusion 532 ofhousing element 500. A forward facingsurface 547 of sealingelement 540 is adapted to engage a rearward facing surface of additionalcircumferential protrusion 534 when thesyringe adaptor element 500 is assembled.Wall portion 544 preferably defines a rear spring seat forcompression spring 536. - A tapered
inner portion 548 ofrear sealing element 540, which has a smaller circumference than that ofhousing element 500, is preferably therewithin at a rear portion thereof.Inner portion 548 is formed forward of and immediately adjacent to wallportion 544 and lies withincompression spring 536. Aradially extending bore 549 is preferably formed ininner portion 548 and ahollow needle 550 is sealingly mounted therein.Inner portion 548 is preferably surrounded by acylindrical portion 552, which terminates at a rearward end thereof inwall portion 544 and which also has a circumference which is smaller than that ofhousing element 500. -
Needle 550 preferably extends axially withincompression spring 536 and through the center ofhousing element 500 andrearward septum 504. A sharpened tip ofneedle 550 is preferably placed betweenforward septum 502 andrearward septum 504, thus maintaining the needle inaccessible to a user and to the atmosphere. - Two generally concave
symmetric surfaces 554 forming a nearly complete cylinder, may extend rearwardly ofwall portion 544 and preferably surround an inner rearwardcylindrical portion 556, which is adapted to engage theluer tip 44 of luer fittedsyringe 40, defining generally symmetric side-facingtabs 558 at rearward ends thereof. The rear portion ofneedle 550 preferably extends axially within innercylindrical portion 556. - Referring specifically to
FIG. 9C , which illustrates an alternative embodiment of the syringe adaptor element ofFIG. 8 , it is seen that aneedle protector 560, preferably made of latex, at least partially coversneedle 550, thus protecting it from the surrounding atmosphere. - Reference is now made to
FIG. 10 , which is a simplified pictorial illustration of spikeport adaptor element 60 which forms part of the drug mixing system ofFIGS. 1A-1M and toFIGS. 11A and 11B which are sectional illustrations taken along section lines XI-XI inFIG. 10 . - Spike
port adaptor element 60 preferably comprises a hollow flexibleplastic tube 602 having associated therewith astandard clamp 604, which is commercially available from various manufacturers, such as Qosina of Italy. - At a forward end thereof,
tube 602 is fitted with ahollow spike element 606 which is preferably side-to-side symmetric and formed of plastic.Spike element 606 is preferably formed of amain body portion 607 which preferably defines at a forward end thereof aspike 608, having formed therein apertures communicating with two axially extendingbores spike 608,main body portion 607 defines a generally semi-circularplanar protrusion 614 adapted to define the location at which a user grips the spike. - Alternatively, as seen with particular clarity in
FIG. 11B ,main body portion 607 may have formed therein a single aperture, which communicates with a singleaxially extending bore 615. - The interior of
tube 602 is in fluid flow communication withbore 612. Abore 616 formed in aneck portion 618 which preferably extends transversely frommain body portion 607 and communicates withbore 610.Hollow neck portion 618 preferably terminates in a forward facingcylindrical portion 620, which sealingly accommodates a generallycircular septum 622 located on aseat 624 which communicates withbore 616. - A sealing
assembly 630 is preferably attached to a rear end oftube 602.Sealing assembly 630 preferably includes at a rearwardmost end thereof a selectably removabletapered sealing section 632, forward of which there is formed a connectingtube portion 634 which is adapted to connect sealingsection 632 totube 602.Sealing assembly 630 is adapted to sealtube 602 during use of the drug mixing device, and may be removed fromtube 602 whenreceptacle 62 is connected directly to an infusion set spike for infusion of the fluid contained therein to a patient. - It is appreciated that the spike connector of
connection assembly 630 of spikeport adaptor element 60 may optionally be replaced by a luer connector. - Reference is now made to
FIGS. 12A and 12B , which are simplified pictorial illustrations of needleport adaptor element 70 which forms part of the drug mixing system ofFIGS. 1A-1M and toFIGS. 13A and 13B , which are sectional illustrations taken along respective section lines XIIIA-XIIIA and XIIIB-XIIIB inFIG. 12A . - Needle
port adaptor element 70 preferably comprises amain body element 700 arranged generally about anaxis 701.Main body element 700 is preferably integrally formed and preferably injection molded of plastic. -
Main body element 700 is preferably side-to-side symmetric aboutaxis 701, and preferably includes arear portion 702 which is generally cylindrical, terminating in aforward wall portion 704 having abore 706 extending therethrough. Each of side surfaces 708 ofrear portion 702 preferably includes a ribbedengagement surface portion 710. - Four axially extending
slots 712 extend alongrear portion 702, eachslot 712 being arranged at generally right angles with respect to its neighboring slots. Defined betweenslots 712 at a rearward facing end ofrear portion 702 are four outwardly taperingtabs 714. Eachtab 714 includes an inwardly facing generallytriangular tooth 715 and terminates in a transversely extendingsection 716.Rear portion 702 preferably surrounds a generallycylindrical portion 718, which extends rearwardly fromforward wall portion 704. - Forward of
wall portion 704 there is formed aneck portion 720, defining aradially extending bore 722. Ahollow needle 724 is adhesively mounted inbore 722 and extends rearwardly thereof alongaxis 701. - Forward of
neck portion 720 there is formed a forward facingcylindrical portion 726, which sealingly supports a generallycircular septum 728 on aseat 730 which is located at a forward end ofcylindrical portion 726. Abore 732 preferably extends radially through forward facingcylindrical portion 726.Bore 732 is preferably in fluid flow engagement with the interior ofhollow needle 724. - A generally
conical cover element 740 which is generally side-to-side and top-to-bottom symmetric aboutaxis 701 preferably is axially slidable with respect tomain body element 700 for selectably surroundingrear portion 702 ofmain body element 700. - A
rear portion 742 ofcover element 740 is preferably outwardly tapered, and terminates in a transversely extendingedge surface 744. Four outwardly facing radially extendingprotrusions 746 lie along an outer surface ofcover element 740, eachprotrusion 746 being arranged at generally right angles with respect to its neighboring protrusions. - Four outwardly facing generally
circumferential protrusions 748 are preferably formed on anouter surface 750 ofcover element 740 betweenprotrusions 746 thus defining a grip region. - At a forward end thereof, an
inner surface 751 ofcover element 740 includes an inwardly taperedsection 752, which is adapted to slidably engage ribbedengagement surface portion 710 ofrear portion 702 ofmain body element 700. Four generally rectangular inwardly facingprotrusions 754 extend fromsection 752, eachprotrusion 754 being arranged at generally right angles with respect to its neighboring protrusions.Protrusions 754 are adapted to slidably engageslots 712 ofrear portion 702 ofmain body element 700. - Reference is now made to
FIG. 14 , which is a simplified pictorial illustration ofsyringe protection cover 80 which forms part of the drug mixing system ofFIGS. 1A-1M and toFIG. 15 , which is a sectional illustration taken along section lines XV-XV inFIG. 14 . -
Syringe protection cover 80 is preferably integrally formed, and is generally side to side symmetric about anaxis 800. A generallycircular locking element 802 is preferably formed at a bottom end ofsyringe protection cover 80. - Locking
element 802 preferably includes a flat generallycircular base surface 804, preferably extending along a plane which is perpendicular toaxis 800.Surface 804 is integrally formed with a generallycylindrical portion 806.Cylindrical portion 806 terminates in a generally circular radially outwardly extendingwall portion 808, which lies in a plane parallel to that defined bysurface 804.Wall portion 808 terminates in a generallycylindrical portion 810, which generally surroundscylindrical portion 806. Anelongate tab 812 extends fromsurface 804 alongaxis 800. - Reference is now made to
FIG. 16 , which is a simplified pictorial illustration of infusion setadaptor element 90 which forms part of the drug mixing system ofFIGS. 1A-1M and toFIG. 17 , which is a sectional illustration taken along section lines XVII-XVII inFIG. 16 . - As seen in
FIGS. 16 and 17 , infusion setadaptor element 90 is preferably integrally formed, and preferably is side-to-side symmetric along anaxis 901. - Infusion set
adaptor element 90 preferably includes a forward facingcylindrical portion 902, which is adapted to surround a generallycircular septum 904 which is sealingly mounted onto aseat 906 which is located at a forward end ofcylindrical portion 902. - A generally cylindrical
intermediate portion 908 is formed rearward ofcylindrical portion 902, having an outer circumference which is slightly smaller than that ofcylindrical portion 902. At a rear end thereof,intermediate portion 908 tapers toward acylindrical neck portion 910, which has an outer circumference which is smaller than that ofintermediate portion 908. - An axially extending
bore 912 extends throughneck portion 910,intermediate portion 908 andcylindrical portion 902, thus allowing fluid flow through infusion setadaptor element 90 when theseptum 904 is suitably pierced. - The assembled structure of the drug mixing system at various stages of use thereof is described hereinbelow with reference to
FIGS. 18A-30 . - Reference is now made to
FIGS. 18A and 18B which are, respectively, a simplified planar illustration and a simplified sectional illustration of. the drug mixing system ofFIG. 1B during attachment ofvial adaptor 30, the sectional illustration being taken along lines XVIIIB-XVIIIB inFIG. 18A . - As seen with particular clarity in
FIG. 18B ,vial puncturing spike 322 ofvial adaptor assembly 30punctures septum 31 located insidetop portion 12 ofvial 10, thus enabling fluid flow between the main body ofvial 10 and forward facingportion 348 ofmain body element 302 ofvial adaptor assembly 30. Preferably, puncturing ofseptum 31 releases any vacuum invial 10 by entrance of air intovial 10 through carbon filter 340 (FIGS. 4 and 6B ) and membrane 336 (FIGS. 4 and 6B ). - Engagement between
vial adaptor assembly 30 andvial 10 is preferably maintained by snap engagement ofprotrusions rear portion 304 ofmain body element 302 with aneck portion 13 ofvial 10. The engagement ofprotrusions neck portion 13 ensures thatvial adaptor assembly 30 is latched ontovial 10 and cannot be removed therefrom.Tabs 310 and outwardlytapered portions 320 generally surroundtop portion 12 andneck portion 13 ofvial 10. - Reference is now made to
FIGS. 19A and 19B and toFIGS. 19C and 19D which are, respectively, a top and a side view simplified planar illustration and a simplified sectional illustration of the drug mixing system ofFIG. 1C during attachment of thesyringe adaptor element 50 tosyringe 40, the sectional illustrations being taken along lines XIXB-XIXB inFIG. 19A and XIXD-XIXD inFIG. 19C . - As seen in
FIGS. 19A-19D , luer 44 of luer fittedhypodermic syringe 40 preferably engages inner rearwardcylindrical portion 556 of sealingelement 540 ofsyringe adaptor element 50 andtabs 558 formed thereon, such thatneedle 550 is in fluid flow engagement with the hollow body ofsyringe 40. - At this stage, the sharpened tip of
needle 550 is preferably placed betweensepta compression spring 536 is relaxed. Preferably, whensyringe 40 is connected tosyringe adaptor assembly 50,plunger 42 ofsyringe 40 is pushed fully inward with respect to the syringe. - Reference is now made to
FIG. 20 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIG. 1D during attachment of spikeport adaptor element 60. - As seen in
FIG. 20 , spike 608 ofspike element 606 of spikeport adaptor element 60 is preferably inserted into aspike port 61 ofreceptacle 62. At this stage,receptacle 62 andtube 602 are in fluid flow engagement. However, clamp 604 is closed and prevents fluid from flowing out of the receptacle throughbore 612 intotube 602. Additionally, bore 610 is in fluid flow communication withcylindrical portion 620 viabore 616 ofneck portion 618. - Reference is now made to
FIG. 21 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIG. 1D during attachment of needleport adaptor element 70. - As seen in
FIG. 21 ,needle 724 of needleport adaptor element 70 is preferably inserted intoneedle port 64 ofreceptacle 62. Preferably,teeth 715 oftabs 714 engageport 64 whenneedle 724 is inserted. Additionally, afterneedle 724 is inserted,cover element 740 is preferably moved with respect tomain body element 700 along ribbed engagement surface portion 710 (FIG. 13B ). - The axial displacement of
cover element 740 preferably seals and locks the connection betweenmain body element 700 andport 64, by pressing ontabs 714 and pushing them inward. Displacement ofcover element 740 includes a corresponding axial displacement ofprotrusions 754 with respect toslots 712 ofrear portion 702 of main body element 700.The axial displacement terminates whensections 716 oftabs 714 engageinner surface 751 ofcover element 740. - At this stage,
receptacle 62 is preferably in fluid flow engagement withbore 732 ofcylindrical portion 726 viaintermediate portion 720 andneedle 724. However, fluid does not flow out ofcylindrical portion 726, as the cylindrical portion is sealed byseptum 728. - Reference is now made to
FIG. 22 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 20 prior to the attachment ofsyringe 40 andsyringe adaptor element 50 to spikeport adaptor element 60. - As seen in
FIG. 22 ,syringe adaptor element 50 andsyringe 40 joined thereto are placed in close proximity tocylindrical portion 620 of spikeport adaptor element 60. It is appreciated that at thisstage compression spring 536 is relaxed and the sharpened tip ofneedle 550 is preferably placed betweensepta teeth 527 ofarms 526 engage forward facing surfaces on either side ofintermediate portion 514 ofhousing element 500. - Throughout the engagement process,
septum 622 of spikeport adaptor element 60 andseptum 502 ofsyringe adaptor element 50 are pushed into touching engagement by the biasing force ofspring 536, thus preventing exposure of the tip ofneedle 550 to the environment. - Reference is now made to
FIG. 23 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 20 following the attachment ofsyringe 40 andsyringe adaptor element 50 to spikeport adaptor element 60. - As seen in
FIG. 23 syringe adaptor element 50 andsyringe 40 joined thereto are pushed into engagement withcylindrical portion 620 of spikeport adaptor element 60. - Preferably, surfaces 528 of
teeth 527 ofarms 526 snap into engagement withwall portion 618, thus ensuring that the engagement betweensyringe adaptor element 50 andcylindrical portion 620 is secure. At this stage,spring 536 is in a compressed state, andhousing element 500 is pushed rearwardly by the pressure fromcylindrical portion 620. - The rearward motion of
housing element 500 causes the sharpened tip ofneedle 550 to piercesepta needle 550 partially extends through the hollow space incylindrical portion 620, and is in fluid flow engagement withreceptacle 62 viabore 610 ofspike 608 ofspiked element 606 and viabore 616 ofneck portion 618. Due to the fluid flow engagement betweenluer 44 ofsyringe 40 andneedle 550 ofsyringe adaptor element 50, thesyringe 40 is now in fluid flow engagement withreceptacle 62. It is appreciated that when using the syringe adaptor element described inFIG. 9C ,needle protector 560 at least partially collapses, thus exposing theneedle 550. - In order to draw fluid from
receptacle 62 intosyringe 40 viaspiked element 606, bore 616 ofneck portion 618,cylindrical portion 620 andneedle 550, a user retractsplunger 42. In order to disengagesyringe adaptor element 50 andcylindrical portion 620, a user pushes slightly onarms 526 extending fromside surfaces 524 ofhousing element 522, causingteeth 527 to move outward and release a rearward facing surface ofcylindrical portion 620, thus disconnecting the cylindrical portion. - Throughout the disengagement process,
septum 622 of spikeport adaptor element 60 andseptum 502 ofsyringe adaptor element 50 are pushed into touching engagement by the biasing force ofspring 536, thus preventing exposure of the tip ofneedle 550 to the environment. - Reference is now made to
FIG. 24 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 21 prior to the attachment ofsyringe 40 andsyringe adaptor element 50 to needle port adaptor element 70.As seen inFIG. 24 ,syringe adaptor element 50 andsyringe 40 joined thereto are placed in close proximity tocylindrical portion 726 of needleport adaptor element 70. It is appreciated that at thisstage compression spring 536 is relaxed and the sharpened tip ofneedle 550 is preferably located betweensepta teeth 527 ofarms 526 engage forward facing surfaces on either side ofintermediate portion 514 ofhousing element 500. - Reference is now made to
FIG. 25 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1E and 21 following the attachment ofsyringe 40 andsyringe adaptor element 50 to needleport adaptor element 70. As seen inFIG. 25 syringe adaptor element 50 andsyringe 40 joined thereto are pushed into engagement withcylindrical portion 726 of needleport adaptor element 70. - Preferably, surfaces 528 of
teeth 527 ofarms 526 snap to engage a rearward facing wall portion ofcylindrical portion 726, thus ensuring that the engagement betweensyringe adaptor element 50 andcylindrical portion 726 is secure. At this stage,spring 536 is in a compressed state, andhousing element 500 is pushed rearwardly by the pressure fromcylindrical portion 726. - The rearward motion of
housing element 500 causes the sharpened tip ofneedle 550 to piercesepta needle 550 partially extends throughbore 732 ofcylindrical portion 726, and is in fluid flow engagement withreceptacle 62 vianeedle 724 ofrear portion 702,neck portion 720 ofmain body element 700 and bore 732 ofcylindrical portion 726. Due to the fluid flow engagement betweenluer 44 ofsyringe 40 andneedle 550 ofsyringe adaptor element 50, thesyringe 40 is now in fluid flow engagement withreceptacle 62. It is appreciated that when using the syringe adaptor element described inFIG. 9C ,needle protector 560 at least partially collapses, thus exposing theneedle 550. - In order to draw fluid from
receptacle 62 intosyringe 40 vianeedle 724, bore 732 andneedle 550, a user retractsplunger 42. In order to disengagesyringe adaptor element 50 andcylindrical portion 726, a user pushes slightly onarms 526 extending fromside surfaces 524 ofhousing element 522, causingteeth 527 to move outward and release a rearward facing wall portion ofcylindrical portion 726, thus disconnectingcylindrical portion 726. - Throughout the engagement and disengagement process,
septum 728 of needleport adaptor element 70 andseptum 502 ofsyringe adaptor element 50 are pushed into touching engagement by the biasing force ofspring 536, thus preventing exposure of the tip ofneedle 550 to the environment. - Reference is now made to
FIG. 26 , which is a sectional illustration of the drug mixing system ofFIG. 1G prior to drug dilution. - As seen in
FIG. 26 ,syringe adaptor element 50 andsyringe 40 joined thereto are placed in close proximity to forward facingportion 348 ofvial adaptor element 30. - It is appreciated that at this
stage compression spring 536 is relaxed and the sharpened tip ofneedle 550 is preferably located betweensepta teeth 527 ofarms 526 engage forward facing surfaces on either side ofintermediate portion 514 ofhousing element 500. - At this stage,
syringe 40 is preferably filled with a fluid drawn from receptacle 62 (FIGS. 22-25 ) and therefore plunger 42 is at least partially retracted. - Reference is now made to
FIG. 27 , which is a sectional illustration of the drug mixing system ofFIG. 1H following drug dilution. - As seen in
FIG. 27 syringe adaptor element 50 andsyringe 40 joined thereto are pushed into engagement with forward facingportion 348 ofvial adaptor element 30. - Preferably, surfaces 528 of
teeth 527 ofarms 526 snap to engagewall portion 346 of forward facingportion 348, thus ensuring that the engagement betweensyringe adaptor element 50 andportion 348 is secure. At this stage,spring 536 is in a compressed state, andhousing element 500 is pushed rearwardly by the pressure from forward facingportion 348. - The rearward motion of
housing element 500 causes the sharpened tip ofneedle 550 to piercesepta needle 550 partially extends through a hollow section ofportion 348, and is in fluid flow engagement withvial 10 viabore 350 ofneck portion 344 andvial puncturing spike 322 ofmain body element 302. Due to the fluid flow engagement betweenluer 44 ofsyringe 40 andneedle 550 ofsyringe adaptor element 50, thesyringe 40 is now in fluid flow engagement withvial 10. It is appreciated that when using the syringe adaptor element described inFIG. 9C ,needle protector 560 at least partially collapses, thus exposing theneedle 550. - At this stage, a user injects the fluid contained in
syringe 40 intovial 10 viabore 350 ofneck portion 344 andvial puncturing spike 322 by inwardly pushingplunger 42 ofsyringe 40. A corresponding volume of air escapes fromvial 10 viamembrane 336 and optionalcarbon cloth filter 340. It is appreciated that any drug containing aerosol is blocked by the membrane and any non-aerosolized drug vapor is adsorbed by the charcoal filter, thus protecting users and the environment from contamination. - Preferably, the user ensures that the drug contained in
vial 10 is fully dissolved, and then draws at least part of the drug solution contained invial 10 intosyringe 40 by turning the system upside down and retracting plunger 42 (not shown). At this stage, a corresponding volume of sterile air entersvial 10 viamembrane 336 and optionalcarbon cloth filter 340. - In order to disengage
syringe adaptor element 50 and forward facingportion 348, a user pushes slightly onarms 526 extending fromside surfaces 524 ofhousing element 522, causingteeth 527 to move outward and release awall portion 346 of forward facingportion 348, thus disconnecting the forward facing portion. - Throughout the engagement and disengagement process,
septum 350 ofvial adaptor element 30 andseptum 502 ofsyringe adaptor element 50 are pushed into touching engagement by the biasing force ofspring 536, thus preventing exposure of the tip ofneedle 550 to the environment. - Reference is now made to
FIG. 28 , which is a sectional illustration of the drug mixing system ofFIGS. 1K and 1L in a protected, ready for delivery state, whensyringe adaptor element 50 is covered bysyringe protection cover 80. - As seen in
FIG. 28 ,syringe adaptor element 50 is preferably covered at a forward end thereof bysyringe protection cover 80. At this stage,plunger 42 is preferably at least partially retracted with respect tosyringe 40, and the syringe contains a drug solution withdrawn from vial 10 (FIG. 27 ). - The forwardmost circumference of
main body portion 523 is preferably seated in the recess formed bywall portions syringe protection cover 80 andsurface 804 ofsyringe cover element 80 preferably engages a forward surface ofseptum 502. - It is appreciated that at this
stage compression spring 536 is relaxed and the sharpened tip ofneedle 550 is preferably located betweensepta teeth 527 ofarms 526 engage forward facing surfaces on either side ofintermediate portion 514 ofhousing element 500. - Reference is now made to
FIG. 29 , which is a partially pictorial, partially sectional illustration of the drug mixing system ofFIGS. 1M and 28 when ready for injection. - As seen in
FIG. 29 ,syringe protection cover 80 has been removed fromsyringe adaptor element 50, andsyringe adaptor element 50 andsyringe 40 joined thereto are pushed into engagement withcylindrical portion 902 of infusion setadaptor element 90, while the infusion setadaptor element 90 is connected to a side port of an intravenous cannula located at an injection site. - Preferably, surfaces 528 of
teeth 527 ofarms 526 snap to engage a rearward facing wall portion ofcylindrical portion 902, thus ensuring that the engagement betweensyringe adaptor element 50 andcylindrical portion 902 is secure. At this stage,spring 536 is in a compressed state, andhousing element 500 is pushed rearwardly by the pressure fromcylindrical portion 902. - The rearward motion of
housing element 500 causes the sharpened tip ofneedle 550 to piercesepta needle 550 partially extends throughbore 912 of infusion setadaptor element 90, and is therefore in fluid flow engagement with the injection site. Due to the fluid flow engagement betweenluer 44 ofsyringe 40 andneedle 550 ofsyringe adaptor element 50, thesyringe 40 is now in fluid flow engagement with the injection site. It is appreciated that when using the syringe adaptor element described inFIG. 9C ,needle protector 560 at least partially collapses, thus exposing theneedle 550. - In order to disengage
syringe adaptor element 50 andcylindrical portion 902, a user pushes slightly onarms 526 extending fromside surfaces 524 ofhousing element 522, causingteeth 527 to move outward and release a the rearward facing wall portion ofcylindrical portion 902, thus disconnecting the cylindrical portion. - Reference is now made to
FIG. 30 , which is a partially pictorial partially sectional illustration of the drug mixing system ofFIGS. 1M and 20 when ready for injection. - Preferably,
receptacle 62 is connected via spikeport adaptor element 60 to an infusion set 92. The infusion set then connects to a standardintravenous cannula 94 such as a Venolit model commercially available from Teva Medical Ltd. of Ashdod, Israel which is located in an infusion site. Typically, prior to connection of spikeport adaptor element 60 to infusion set 92, sealingelement 630 is removed, and infusion set 92 is connected directly totube 602. - Alternatively, infusion set 92 may be connected to a new receptacle, not containing a drug, in which case the drug solution is injected directly into the infusion set. If this option is selected,
syringe adaptor 50 having syringe 40 (FIG. 28 ) joined thereto is connected to port 93 aftersyringe protector cover 80 is removed, and the drug solution contained therein is injected into the infusion line. - Preferably, surfaces 528 of
teeth 527 ofarms 526 snap to engage a rearward facing wall portion ofport 93, thus ensuring that the engagement betweensyringe adaptor element 50 andport 93 is secure. At this stage,spring 536 is in a compressed state, andhousing element 500 is pushed rearwardly by the pressure fromport 93. - The rearward motion of
housing element 500 causes the sharpened tip ofneedle 550 to pierceseptum 502 and a sealing septum ofport 93. As a result,needle 550 partially extends into infusion set 92, and is therefore in fluid flow engagement with the injection site. Due to the fluid flow engagement betweenluer 44 ofsyringe 40 andneedle 550 ofsyringe adaptor element 50, thesyringe 40 is now in fluid flow engagement with the injection site. - In order to disengage
syringe adaptor element 50 andport 93, a user pushes slightly onarms 526 extending fromside surfaces 524 ofhousing element 522, causingteeth 527 to move outward and release a rearward facing wall portion ofport 93, thus disconnecting the port. - Reference is now made to
FIGS. 31A, 31B, 31C, 31D, 31E, 31F, 31G, 31H, 31I, 31J and 31L which are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with another preferred embodiment of the present invention. -
FIG. 31A shows a spikeport adaptor element 1030, as described hereinbelow with reference toFIGS. 34-35 , being inserted into aspike port 1031 in areceptacle 1032 containing a fluid. Preferably, a luer connector of spikeport adaptor element 1030 is sealed by aluer cover element 1034. - Typically,
receptacle 1032 comprises a bag, and the fluid contained therein is sterile salt solution, water, or any other suitable sterile solution or pure fluid. - As shown in
FIG. 31B , a luer-equippedhypodermic syringe 1040, having aplunger 1042 and aluer tip 1044, is connected to a syringe port of anadaptor assembly 1050, which is described hereinbelow with reference toFIGS. 36 and 44-45B . Preferably, the syringe port is defined by astopcock 1052 which is described hereinbelow with reference toFIGS. 37-38B and includes aremovable protection cap 1054.FIG. 46 shows a sectional view of the drug mixing system at this stage. - Typically,
plunger 1042 ofsyringe 1040 is pushed fully inward before the syringe is connected to the syringe port ofstopcock 1052. -
FIG. 31C shows spikeport adaptor element 1030 andreceptacle 1032 joined thereto being connected to areceptacle adaptor subassembly 1056 ofadaptor assembly 1050.Subassembly 1056 is described hereinbelow with reference toFIGS. 39-40B . Preferably,stopcock 1052 is in an operative orientation which enables fluid flow betweenreceptacle adaptor subassembly 1056 andsyringe 1040.FIG. 47 shows a sectional view of the drug mixing system at this stage. - As seen in
FIG. 31D , avial 1060, including atop portion 1062 and aneck portion 1063, is pushed into engagement with avial adaptor subassembly 1058 ofadaptor assembly 1050.Top portion 1062 ofvial 1060 preferably has aseptum 1064 sealingly seated therein.Subassembly 1058 is described hereinbelow with reference toFIGS. 41-42B . - Alternatively, if a
small vial 1066 is used,small vial 1066 is pushed into engagement with a vialhead adaptor element 1068, which is described hereinbelow with reference toFIGS. 32-33 , as shown inFIG. 31E , and is then pushed into engagement withvial adaptor subassembly 1058.Vials FIG. 48 shows a sectional view of the drug mixing system at this stage. - It is appreciated that
stopcock 1052,receptacle adaptor subassembly 1056 andvial adaptor subassembly 1058 are preferably enclosed in ahousing element 1070 ofadaptor assembly 1050, which is described hereinbelow with reference toFIGS. 43A-43B . - It will be appreciated by persons skilled in the art that the assembly steps shown in
FIGS. 31C-31E may be performed in any suitable sequence. - As seen in
FIG. 31F , a user retractsplunger 1042 whilereceptacle 1032 is upright andvial 1060 lies therebelow, thus at least partially fillingsyringe 1040 with fluid drawn fromreceptacle 1032. The operative orientation ofstopcock 1052 enables this fluid flow fromreceptacle 1032 tosyringe 1040 via spikeport adaptor element 1030,receptacle adaptor subassembly 1056 andstopcock 1052 in a manner that ensures that the fluid remains sterile, and that the user is not exposed thereto.FIG. 49 shows a sectional view of the drug mixing system at this stage. - The user then rotates a
handle 1080 ofstopcock 1052 to enable fluid flow betweensyringe 1040 andvial adaptor subassembly 1058, having joined theretovial 1060, as shown inFIG. 31G . - When the
syringe 1040 andvial 1060 are in fluid flow engagement, the user pushesplunger 1042 inward, thus injecting the fluid contained insyringe 1040 intovial 1060 and dissolving the drug contained therein.FIG. 50 shows a sectional view of the drug mixing system at this stage. - As seen in
FIG. 31H , the user then shakes the drug mixing system ofFIG. 31G to ensure that the drug invial 1060 is fully dissolved and that the resulting solution is homogenous. - As seen in
FIG. 31I , the user turns the system upside down, so that thevial 1060 faces upward, and then retractsplunger 1042, thus drawing at least part of the solution fromvial 1060 intosyringe 1040.FIG. 51 shows a sectional view of the drug mixing system at this stage. - It will be appreciated by those skilled in the art that at this stage the drug mixing system of the present invention is preferably held such that
vial 1060 lies abovesyringe 1040, to allow smooth flow of the fluid fromvial 1060 tosyringe 1040 viavial adaptor subassembly 1058 andstopcock 1052. - As shown in
FIG. 31J , handle 1080 ofstopcock 1052 is oriented to enable flow of fluid betweensyringe 1040 andreceptacle 1032. The user then pushesplunger 1042 ofsyringe 1040 inward, thus injecting the drug solution intoreceptacle 1032 and further diluting it prior to infusion into a patient.FIG. 52 shows a sectional view of the drug mixing system at this stage. - Subsequently, spike
port adaptor element 1030, havingreceptacle 1032 joined thereto, is disconnected fromadaptor assembly 1050, which remains connected tovial 1060 as shown inFIG. 31K . - As seen in
FIG. 31L , if some of the drug solution is left invial 1060,vial 1060 andadaptor assembly 1050 joined thereto may be stored in a suitable facility for further use. It is appreciated that at thisstage syringe 1040 remains connected to the syringe port ofstopcock 1052 ofadaptor assembly 1050.FIG. 53 is a sectional view of the drug mixing system at this stage. - The structure of elements of the drug mixing system of
FIGS. 31A-31L is described hereinbelow with reference toFIGS. 32-43B . - Reference is now made to
FIG. 32 , which is a simplified pictorial illustration of a vialhead adaptor element 1068 which forms part of the drug mixing system ofFIGS. 31A-31L and toFIG. 33 which is a sectional illustration taken along section lines XXXIII-XXXIII inFIG. 32 . - As seen in
FIG. 32 , vialhead adaptor element 1068 is preferably a side-to-side symmetric integrally formed element which is preferably injection molded of plastic. - Vial
head adaptor element 1068 preferably includes amain body portion 1200 which is generally cylindrical and has acentral axis 1201. An innercylindrical surface 1202 ofmain body portion 1200 preferably has fourarms 1204 extending therefrom, eacharm 1204 being arranged at generally right angles with respect to its neighboring arms. - Each of
arms 1204 terminates at an upper end thereof, in the sense ofFIG. 31A , in an inwardly facing generallytriangular tooth 1206 having a upwardly facinginclined surface 1208 and a bottom-facingengagement surface 1210 extending generally perpendicular toarm 1204. - At the bottom of vial
head adaptor element 1068, there are formed four inwardly protrudingsurfaces 1212, extending generally perpendicular toinner surface 1202 ofmain body portion 1200. Each of neighboringsurfaces 1212 is preferably arranged at a generally right angle with respect to its neighboringsurfaces 1212.Surfaces 1212 andarms 1204 are rotationally offset from one another aboutaxis 1201. - Reference is now made to
FIG. 34 , which is a simplified pictorial illustration of spikeport adaptor element 1030 which forms part of the drug mixing system ofFIGS. 31A-31L and toFIG. 35 which is a sectional illustration taken along section lines XXXV-XXXV inFIG. 34 . - Spike
port adaptor element 1030 preferably comprises a hollow flexibleplastic tube 1302 having associated therewith astandard clamp 1304, which is commercially available from various manufacturers such as Quosina of Italy. At a forward end thereof,tube 1302 is connected to atube port 1305 of ahollow spike element 1306 which is preferably formed of plastic.Spike element 1306 preferably includes amain body portion 1307 which defines at a forward end thereof aspike 1308 which includes an aperture communicating with anaxially extending bore 1310 and anadditional bore 1312 which extends partially throughmain body portion 1307 and communicates with a top portion ofbore 1310, thus facilitating complete priming before drug injection. - Rearward of
spike 1308,main body portion 1307 defines a generally circularplanar protrusion 1314 adapted to define the location at which a user grips the spike. - The interior of
tube 1302 is in fluid flow communication withbore 1312 viatube port 1305.Bore 1310 preferably terminates in an aperture located inspike 1308 ofmain body portion 1307, and fully extends through thebody portion 1307. -
Main body portion 1307 preferably terminates in aconnection port 1318 which is adapted to connect spikeport adaptor element 1030 toreceptacle adaptor subassembly 1056.Connection port 1318 preferably sealingly accommodates a generallycircular septum 1320 on aseat 1322.Septum 1320 preferably engages the rear end ofbore 1310, thus sealing the rear end of the bore. - Forward of
connection port 1318, there is formed on main body portion 1307 acircumferential protrusion 1324, forward of which is formed an additionalcircumferential protrusion 1326, having an outer circumference which is slightly larger than that ofprotrusion 1324.Protrusions port adaptor element 1030 when it is connected toreceptacle adaptor subassembly 1056. - A
luer connector 1330 is preferably attached to a rear end oftube 1302.Luer connector 1330 preferably includes at a rearwardmost end thereof a narrowhollow port section 1332, forward of which there is formed a connectingtube portion 1334 and ahollow neck portion 1336 which connectsport section 1330 totube 1302. Preferably,luer connector 1330 is sealed byluer cover element 1034. - It is appreciated that spike
port adaptor element 1030 may alternatively be identical to spikeport adaptor element 630 described hereinabove with reference toFIGS. 10-11B . - Reference is now made to
FIG. 36 , which is a simplified exploded view illustration ofadaptor assembly 1050 which forms part of the drug mixing system ofFIGS. 31A-31L . - As seen with particular clarity in
FIG. 36 ,adaptor assembly 1050 includesvial adaptor subassembly 1058, onto which is placed ahydrophobic membrane 1402, above which is optionally seated acarbon cloth filter 1404.Vial adaptor subassembly 1058 is connected at a forward portion thereof to avial port 1082 ofstopcock 1052, which additionally includes asyringe port 1084 adapted for engagement withluer 1044 ofsyringe 1040.Stopcock 1052 additionally includes areceptacle port 1086 which is adapted for connection to arear connection element 1406 ofreceptacle adaptor subassembly 1056. - Preferably, when
syringe 1040 is not connected to the syringe port ofstopcock 1052, thesyringe port 1084 is sealed byprotection cap 1054. - A
needle holding element 1408 is preferably seated withinrear connection element 1406 and supports aneedle 1410. A forward portion ofneedle 1410 is preferably protected by a flexible latexneedle protection element 1412.Receptacle adaptor subassembly 1056 connects at a rearward end thereof torear connection element 1406, enclosingneedle holding element 1408,needle 1410 andneedle protection element 1412. - The forward portion of
vial adaptor subassembly 1058 as well asstopcock 1052 and the rear portion ofreceptacle adaptor subassembly 1056 are located withinhousing element 1070. However, ahandle 1080 ofstopcock 1052 protrudes fromhousing element 1070, thus enabling a user to change the operative orientation of thestopcock 1052 and thereby switch the fluid flow pathway. - Reference is now made to
FIG. 37 , which is a simplified pictorial illustration ofstopcock 1052 which forms part of the adaptor assembly ofFIG. 36 and toFIGS. 38A and 38B , which are sectional illustrations taken along respective section lines XXXVIIIA-XXXVIIIA and XXXVIIIB-XXXVIIIB inFIG. 37 . -
Stopcock 1052, as noted hereinabove, has avial port 1082, asyringe port 1084 and areceptacle port 1086, all of which are defined in ahousing portion 1090. Useroperable handle 1080 is fixed to apathway defining element 1092, which defines a three-way direction pathway, as seen with particularity inFIG. 38B . Selectable rotational orientation ofhandle 1080 enables any two ofports Stopcock 1052 is commercially available from Eleam Ltd. of Baram, Israel. - Reference is now made to
FIG. 39 , which is a simplified pictorial illustration ofreceptacle adaptor subassembly 1056 which forms part of the adaptor assembly ofFIG. 36 and toFIGS. 40A and 40B , which are sectional illustrations taken along respective section lines XLA-XLA and XLB-XLB inFIG. 39 . - As seen in
FIGS. 39-40B ,receptacle adaptor subassembly 1056 includes amain body element 1600 which is arranged generally about anaxis 1601.Main body element 1600 is preferably integrally formed of plastic, and is preferably side-to-side symmetric aboutaxis 1601.Main body element 1600 preferably includes a generallycylindrical base portion 1602 terminating in arear portion 1604. - Top and bottom generally
concave wall portions 1606 are formed at a forward end ofbase portion 1602, eachwall portion 1606 defining on an outer surface thereof an outwardly facing axially extendingrib 1608, which extends from a forwardmost end of each ofwall portions 1606 and alongbase portion 1602. - A
connection surface 1610 extending transversely fromside surfaces 1612 ofbase portion 1602 connects an outwardly extendingarm 1614 to eachside surface 1612. Eacharm 1614 preferably has a generally squarerear portion 1616, formed rearwardly ofconnection surface 1610, and has a radially extending outwardly facingprotrusion 1618 formed thereon.Protrusion 1618 preferably extends onto an outer surface of a generallyrectangular forward portion 1620 of each ofarms 1614, which extends forwardly ofconnection surface 1610. - An inwardly facing generally
triangular tooth 1622 is formed adjacent a top end of each offorward portions 1620. Eachtooth 1622 preferably includes a forwardly facinginclined surface 1624 and a rearwardly facingengagement surface 1626. -
Rear portion 1604 preferably includes a transversely extending generallycircular portion 1630 which forms a base forribs 1608 and which terminates at a rear end thereof in an axially extending generallycylindrical wall portion 1632. -
Wall portion 1632 preferably defines on a top and bottom surface thereof a small generallyrectangular window 1634, and two forwardly facingslots 1636 which are formed on either side ofwindow 1634. Two generally symmetric side-facingtabs 1638 are formed onside surfaces 1640 ofwall portion 1632, eachtab 1638 being formed forwardly of a generally rectangular forwardly facingslot 1642. -
Rear connection element 1406 preferably includes aforward disk 1652 defining acentral bore 1654.Disk 1652 preferably functions as a terminating wall for a forward facingcylindrical portion 1656. Rearward ofdisk 1652 there is preferably formed arear portion 1658, having anarrow bore 1660 extend therethrough.Bore 1660 preferably widens toward the rear end ofrear portion 1658, thus enablingrear portion 1658 to connect to an appropriate port. Preferably, two generallysymmetric tabs 1662 are formed on top and bottom surfaces ofrear portion 1658.Cylindrical portion 1656 preferably has an outer circumference that is slightly smaller than that ofwall portion 1632, and is located therein. -
Needle holding element 1408 preferably supportsneedle 1410 on a generallycircular disk portion 1672.Needle 1410 extends axially throughbase portion 1602 ofmain body element 1600 and throughbore 1660 of rear connection element 1650.Disk portion 1672 is preferably seated incylindrical portion 1656, and is locked intocylindrical portion 1656 byportion 1630. - Reference is now made to
FIG. 41 , which is a simplified pictorial illustration ofvial adaptor subassembly 1058 which forms part ofadaptor assembly 1050 ofFIG. 36 and toFIGS. 42A and 42B , which are sectional illustrations taken along respective section lines XLIIA-XLIIA and XLIIB XLIIB inFIG. 41 . - As seen in
FIGS. 41-42B ,vial adaptor subassembly 1058 comprises amain body element 1702 arranged generally about anaxis 1703.Main body element 1702 is preferably integrally formed and preferably injection molded of plastic. -
Main body element 1702 is preferably side-to-side symmetric aboutaxis 1703, and preferably includes arear portion 1704, which is generally cylindrical and terminates in aforward wall 1706.Rear portion 1704 comprises aforward base section 1708, preferably having four transversely extending outwardly facingprotrusions 1709 extend therefrom, each protrusion being arranged at generally right angles with respect to its neighboring protrusions. - Rearward of
base section 1708 there are formed fourtabs 1710 each having arectangular window 1712. Rearward ofrectangular windows 1712 and on aninner surface 1714 of each oftabs 1710 there are preferably formed two radially extending inwardly facingprotrusions 1716 each having an inclined surface.Protrusions 1716 preferably terminate at a forward end thereof in an inwardly facing transversely extendingprotrusion 1718. Rearward ofprotrusions 1716, each oftabs 1710 preferably includes an outwardlytapered portion 1720. - A hollow
vial puncturing spike 1722 extends rearwardly from arearward surface 1724 offorward wall 1706, and is surrounded bybase section 1708 and bytabs 1710.Rearward surface 1724 additionally includes a circularcylindrical protrusion 1725, surrounding puncturingspike 1722. Two axially extendingbores vial puncturing spike 1722. - Forward of
forward wall 1706 ofrear portion 1704 there is formed an intermediate portion which is formed of two generallyrectangular surfaces 1728, and which includes anaxial tubular portion 1730 having abore 1731 extend therethrough, bore 1731 being in fluid flow engagement withbore 1726 of hollowvial puncturing spike 1722. - On the top
rectangular surface 1728 and slightly recessed with respect thereto there is formed a plasticmembrane support surface 1732, having formed thereon a plurality of generally evenly distributedspherical protrusions 1734, which are adapted to supporthydrophobic membrane 1402 and prevent it from excessive inflation and from cracking.Membrane 1402 is adapted to allow free passage of air to and frommain body element 1702, but to prevent passage of liquid and air borne particles, microorganisms and aerosol. Apreferred membrane 1402 is Model Versapor R 0.2 Micron which is commercially available from Pall Corporation of New York, U.S.A.Membrane 1402 is in fluid flow engagement with vial puncturing spike viabore 1727 and via arecess 1737 formed in toprectangular surface 1728. - A
rim 1738 surroundingsupport surface 1732 is adapted to support acarbon cloth filter 1404 and maintain it in a raised position above and spaced frommembrane 1402.Carbon filter 1404 is adapted to prevent toxic vapors from escaping frommain body element 1702, thus protecting users. A preferredcarbon cloth filter 1404 is Model No. Zorflex EMI which is commercially available from Charcoal Cloth International Ltd. of Houghton-le-Spring, England. -
Rectangular surfaces 1728 of the intermediate portion terminate at a forward end thereof in a forward facingcylindrical portion 1748, having abore 1750 extend therethrough. Preferably, bore 1750 is a continuation oftubular portion 1730 of the intermediate portion. - It is appreciated that the functionalities of
membrane 1402 andcarbon cloth filter 1404, to allow free passage of air into the drug mixing system while preventing passage thereinto of liquid and air-borne particles, microorganisms and aerosol and preventing toxic vapors from escaping from the drug mixing system, may be incorporated, using similar elements, into spikeport adaptor element 1030 orreceptacle adaptor subassembly 1056. - Reference is now made to
FIGS. 43A and 43B , which are simplified pictorial illustrations of thehousing element 1070 which forms part of theadaptor assembly 1050 ofFIG. 36 in closed and open orientations, respectively. - As seen in
FIGS. 43A and 43B ,housing element 1070 is preferably integrally formed about anaxis 1800 and includes atop housing portion 1801 and abottom housing portion 1802. Preferably,housing portions axis 1800. Preferably, each ofhousing portions forward portion 1804 and a semi-cylindricalrearward portion 1806. -
Top housing portion 1801 includes an inwardly recessedportion 1808 including a generallyround aperture 1810 which extends forwardly into anelongate aperture 1812. Rearward ofaperture 1810 there is preferably formed anelongate protrusion 1814. Preferably,apertures handle 1080 ofstopcock 1052 whenadaptor assembly 1050 is assembled. -
Bottom housing portion 1802 includes an inwardly recessedportion 1816 which is generally symmetrical to recessedportion 1808 oftop housing portion 1801, and which includes a central generallyround aperture 1818. Twoelongate protrusions 1820 are formed on either side ofaperture 1818, such thatrearward protrusion 1820 is generally symmetrical toprotrusion 1814 oftop housing portion 1801. Preferably, a bottom portion ofpathway defining element 1090 ofstopcock 1052 extends throughaperture 1818 whenadaptor assembly 1050 is assembled. -
Top housing portion 1801 includes at forward and rearward ends thereof outwardly extendingfingers 1822 terminating in a generallytriangular teeth 1824 which include inclined outwardly facingsurfaces 1826 and engagement surfaces 1828.Bottom housing portion 1802 preferably includes at forward and rearward ends thereof two generallyrectangular windows 1830 which are placed generally belowfingers 1822 and are adapted to engageengagement surfaces 1828 offingers 1822 whenhousing element 1070 is assembled. - An
inner surface 1834 ofhousing element 1070 preferably includes at a rearward end thereof acircumferential recess 1836 which is adapted to engageprotrusions 1709 ofrear portion 1704 ofvial adaptor subassembly 1058. An outer surface ofhousing element 1070 which lies aboverecess 1836 preferably includes an outwardly facingprotrusion 1840 which protrudes out ofcylindrical forward portion 1804. - Preferably, side surfaces of
top housing portion 1801 andbottom housing portion 1802 include generally parallel generallyrectangular slots 1842, through whichsyringe port 1084 ofstopcock 1052 extends whenadaptor assembly 1050 is assembled. - Reference is now made to
FIG. 44 , which is a simplified assembled pictorial illustration of the adaptor assembly ofFIG. 36 and toFIGS. 45A and 45B , which are sectional illustrations taken along respective section lines XLVA-XLVA and XLVB XLVB inFIG. 44 . - As seen in
FIGS. 44-45B ,rear portion 1704 ofvial adaptor subassembly 1058 extends from a rear portion ofhousing element 1070.Vial puncturing spike 1722 preferably extends out ofhousing element 1070, and is accessible for connection ofvial 1060 or of vial 1066 (FIG. 31E ) thereto. - Preferably,
circumferential recess 1836 ofinner surface 1834 ofhousing element 1070 engagesprotrusions 1709 ofrear portion 1704 ofvial adaptor subassembly 1058. Preferably, forward facingcylindrical portion 1748 engagesvial port 1082 ofstopcock 1052. - A forward portion of
main body element 1600 ofreceptacle adaptor subassembly 1056 preferably extends from a forward portion ofhousing element 1070 ofadaptor assembly 1050, and surroundsneedle 1410 enclosed inneedle protection element 1412. Main bodyelement including needle 1410 andneedle protection cover 1412 is preferably accessible for connection of spike port adaptor element 1030 (FIGS. 34-35 ) thereto. - Preferably,
rear portion 1658 ofrear connection element 1406 engagesreceptacle port 1086 ofstopcock 1052. A rear end ofneedle 1410 at least partially extends throughbore 1660 such thatneedle 1410 is in fluid flow communication withreceptacle port 1086. -
Syringe port 1084 ofstopcock 1052 preferably extends fromhousing element 1070 throughslots 1842 formed in side surfaces thereof. Preferably,pathway defining element 1092 extends fromapertures top housing portion 1801, and a bottom portion ofstopcock 1052 extends throughaperture 1818 of bottom housing element. -
Housing element 1070 is preferably assembled such thattop housing portion 1801 andbottom housing portion 1802 are connected by engagement ofengagement surfaces 1828 ofteeth 1824 oftop housing portion 1801 andwindows 1830 ofbottom housing portion 1802. - Reference is now made to
FIG. 46 , which is a sectional illustration of the drug mixing system ofFIG. 31B during attachment ofsyringe 1040 to theadaptor assembly 1050 ofFIGS. 44-45B . - As seen in
FIG. 46 ,luer tip 1044 ofsyringe 1040 is attached tosyringe port 1084 ofstopcock 1052. At this stage, handle 1080 ofstopcock 1052 is positioned such that fluid can flow fromreceptacle port 1086 tosyringe 1040 thereof. It is appreciated that at thisstage plunger 1042 ofsyringe 1040 is preferably pushed fully inward in the syringe. - Reference is now made to
FIG. 47 , which is a sectional illustration of the drug mixing system ofFIG. 31C during attachment of spikeport adaptor element 1030 and receptacle 1032 ofFIG. 31A to thereceptacle adaptor subassembly 1056 of theadaptor assembly 1050 ofFIG. 46 . - As seen in
FIG. 47 , spikeport adaptor element 1030, havingreceptacle 1032 joined thereto, is connected toreceptacle adaptor subassembly 1056 ofadaptor assembly 1050. -
Spike 1308 is preferably previously inserted intospike port 1031 ofreceptacle 1032, such that bore 1310 ofspike element 1306 engages fluid content ofreceptacle 1032.Connection port 1318 of spikeport adaptor element 1030 engageswall portions 1606 andbase portion 1602 ofmain body element 1600 ofreceptacle adaptor subassembly 1056. -
Connection port 1318 is preferably locked into connection withreceptacle adaptor subassembly 1056 by engagement ofengagement surfaces 1626 offorward portions 1620 of arms 1614 (FIG. 40B ) and a rearward facing wall portion ofconnection port 1318. - Preferably,
needle 1410 punctures needleprotection cover 1412 andseptum 1320, resulting in a change to the structure of the needle protection cover. At this stage,receptacle 1032 is in fluid flow communication withsyringe 1040 viabore 1310 ofspike 1308 of spikeport adaptor element 1030,needle 1410, bore 1660 and receptacle port andsyringe port 1084 ofstopcock 1052. - Reference is now made to
FIG. 48 , which is a sectional illustration of the drug mixing system ofFIG. 31 D during attachment ofvial 1060 tovial adaptor subassembly 1058 of theadaptor assembly 1050 ofFIG. 47 . -
Vial 1066 and vialhead adaptor element 1068 joined thereto (FIG. 31E ) orvial 1060 is preferably pushed into engagement withvial puncturing spike 1722 ofvial adaptor subassembly 1058. - Typically,
vial puncturing spike 1722 ofvial adaptor subassembly 1058 punctures septum 1064 located insidetop portion 1062 ofvial 1060, thus enabling fluid flow between the main body ofvial 1060 andcylindrical portion 1748 ofmain body element 1702 ofvial adaptor subassembly 1058. Preferably, puncturing ofseptum 1064 releases any vacuum invial 1060 by entrance of air intovial 1060 through carbon filter 1404 (FIG. 42B ) and membrane 1402 (FIG. 42B ). - Engagement between
vial adaptor subassembly 1058 andvial 1060 is preferably maintained by snap engagement ofprotrusions 1716 and 1718 (FIGS. 42A and 42B ) ofrear portion 1704 ofmain body element 1702 with aneck portion 1063 ofvial 1060. The engagement ofprotrusions neck portion 1063 ensures thatvial adaptor subassembly 1058 is latched ontovial 1060 and cannot be removed therefrom.Tabs 1710 and outwardlytapered portions 1720 generally surroundtop portion 1062 andneck portion 1063 ofvial 1060. - At this stage, the main body of
vial 1060 is in fluid flow communication withsyringe port 1084 viavial puncturing spike 1722, bore 1750 ofcylindrical portion 1748 andvial port 1082 ofstopcock 1052. - Reference is now made to
FIG. 49 , which is a sectional illustration of the drug mixing system ofFIGS. 31F and 48 during fluid drawing fromreceptacle 1032 intosyringe 1040. - At this stage,
plunger 1042 ofsyringe 1040 is preferably retracted, thus drawing fluid fromreceptacle 1032 intosyringe 1040. Fluid drawn fromreceptacle 1032 reachessyringe 1040 viabore 1310 ofspike 1308 of spikeport adaptor element 1030,needle 1410, bore 1660 ofreceptacle adaptor subassembly 1056,receptacle port 1086,pathway defining element 1092,syringe port 1084 andluer tip 1044. - Reference is now made to
FIG. 50 , which is a sectional illustration of the drug mixing system ofFIGS. 31G and 48 during injection of fluid fromsyringe 1040 intovial 1060. - Initially, the user rotates
handle 1080 ofstopcock 1052, thus bringingsyringe port 1084 into fluid flow engagement withvial port 1082. - Preferably, the user pushes
plunger 1042 ofsyringe 1040 inwardly with respect tosyringe 1040, resulting in injection of fluid fromsyringe 1040 tovial 1060, thus dissolving the drug contained in the vial. The fluid injected fromsyringe 1040 flows tovial 1060 vialuer tip 1044 ofsyringe 1040,syringe port 1084,pathway defining element 1092,vial port 1082, bore 1750 ofcylindrical portion 1748 andvial puncturing spike 1722. - The user preferably shakes the drug mixing system of
FIG. 50 as shown inFIG. 31H , in order to ensure that the drug contained invial 1060 is fully dissolved, and that the drug solution is homogenous. - Reference is now made to
FIG. 51 , which is a sectional illustration of the drug mixing system ofFIGS. 31I and 48 during drawing of fluid fromvial 1060 intosyringe 1040. - At this stage, the user positions the system such that
vial 1060 is on top, and preferably draws at least part of the drug solution contained invial 1060, by at least partially retractingplunger 1042 ofsyringe 1040. The fluid drawn fromvial 1060 flows intosyringe 1040 viavial puncturing spike 1722, bore 1750 ofcylindrical portion 1748,vial port 1082,pathway defining element 1092 andsyringe port 1084 ofstopcock 1052 andluer tip 1044 ofsyringe 1040. - Reference is now made to
FIG. 52 , which is a sectional illustration of the drug mixing system ofFIGS. 31J and 48 during injection of fluid fromsyringe 1040 intoreceptacle 1032. - At a first stage, the user rotates
handle 1080 ofstopcock 1052, resulting insyringe port 1084 being in fluid flow engagement withvial port 1082. - Subsequently,
plunger 1042 ofsyringe 1040 is preferably pushed inward with respect to the main body portion of the syringe. The inward displacement ofplunger 1042 causes injection of fluid fromsyringe 1040 intoreceptacle 1032. Fluid drawn fromsyringe 1040 reachesreceptacle 1032 vialiter tip 1044,syringe port 1084,pathway defining element 1092,receptacle port 1086 ofstopcock 1052, bore 1660 ofreceptacle adaptor subassembly 1056,needle 1410 and bore 1310 ofspike 1308 of spikeport adaptor element 1030. - Reference is now made to
FIG. 53 , which is a sectional illustration of the drug mixing system ofFIG. 31L when ready for storage. - As shown in
FIG. 53 , spike port adaptor element 1030 (FIGS. 34-35 ) andreceptacle 1032 joined thereto are disconnected fromreceptacle adaptor subassembly 1056 ofadaptor assembly 1050. Typically, spikeport adaptor element 1030 is disconnected fromreceptacle adaptor subassembly 1056 by slightly pushingarms 1614 extending from side surfaces 1612 (FIGS. 39-40B ) ofbase portion 1602, causingteeth 1620 to move outward and release the rearward facing wall portion of connection port 1318 (FIGS. 34-35 ), thus disconnecting the connection port. Typically,needle 1410 is released fromconnection port 1318, andneedle protection cover 1412 is deployed and once again fully enclosesneedle 1410, thus preventing liquid spill and aerosol spray. -
Adaptor assembly 1050, includingvial adaptor subassembly 1058,stopcock 1052,receptacle adaptor subassembly 1056 andhousing element 1070, is preferably stored in a suitable cooling facility. During cooling thereof, adaptor assembly is preferably connected tosyringe 1040, havingplunger 1042 fully pushed inward, and tovial 1060 containing a drug solution therein. Typically,pathway defining element 1092 ofstopcock 1052 connectsreceptacle port 1086 tosyringe port 1084 at this stage. Reference is now made toFIGS. 54A, 54B, 54C, 54D, 54E, 54F, 54G and 54H which are simplified pictorial illustrations of various stages of assembly and typical use of a drug mixing system constructed and operative in accordance with yet another preferred embodiment of the present invention. -
FIG. 54A shows a spikeport adaptor element 2010, as described hereinbelow with reference toFIGS. 57-58 , being inserted into aspike port 2011 in areceptacle 2012 containing a fluid. Preferably, a luer connector of spikeport adaptor element 2010 is sealed by aluer cover element 2014. - Typically,
receptacle 2012 comprises a bag, and the fluid contained therein is sterile salt solution, water, or any other suitable sterile solution or pure fluid. - As seen in
FIG. 54B , avial 2020, including atop portion 2022 and aneck portion 2023, is pushed into engagement with avial adaptor subassembly 2044 ofadaptor assembly 2040.Top portion 2022 ofvial 2020 preferably has aseptum 2024 sealingly seated therein.Subassembly 2044 is described hereinbelow with reference toFIGS. 60-61B . - Alternatively, if a
small vial 2026 is used,small vial 2026 is pushed into engagement with a vialhead adaptor element 2030 which is described hereinbelow with reference toFIGS. 55-56 as shown inFIG. 54C , and is then pushed into engagement withvial adaptor subassembly 2044.Vials FIGS. 67A and 67B show a sectional view of the drug mixing system at this stage. -
FIG. 54D shows spikeport adaptor element 2010 andreceptacle 2012 joined thereto, being connected to areceptacle adaptor subassembly 2046 ofadaptor assembly 2040, which is described hereinbelow with reference toFIGS. 62-63B . - It is appreciated that
receptacle adaptor subassembly 2046 andvial adaptor subassembly 2044 are preferably enclosed in ahousing element 2050 ofadaptor assembly 2040, which is described hereinbelow with reference toFIGS. 64A-64B . - it is appreciated by persons skilled in the art that the assembly steps shown in
FIGS. 54A-54D may be performed in any suitable sequence. - As seen in
FIG. 54E , a user holdsreceptacle 2012 upright and squeezes the receptacle, thus at least partially fillingvial 2020 with fluid squeezed out ofreceptacle 2012. This flow of fluid ensures that the fluid remains sterile, and that the user is not exposed thereto. - As seen in
FIG. 54F , the user then shakes the drug mixing system ofFIG. 54E to ensure that the drug invial 2020 is fully dissolved and that the resulting solution is homogenous. - As seen in
FIG. 54G , the user reverses the direction of thereceptacle 2012, such that it is now facing downward, and then squeezes the receptacle. Squeezing of thereceptacle 2012 causes the drug solution contained invial 2020 to be drawn into the receptacle, thus further diluting the solution. The user preferably repeats this action untilvial 2020 is empty, thus diluting the entire content of the vial in a single receptacle. - As shown in
FIG. 54H , spikedreceptacle adaptor element 2010 havingreceptacle 2012 joined thereto is disconnected fromadaptor assembly 2040, which remains connected tovial 2020. It is appreciated that at thisstage adaptor assembly 2040 andvial 2020 may be disposed of. - The structure of elements of the drug mixing system of
FIGS. 54A-54H is described hereinbelow with reference toFIGS. 55-64B . - Reference is now made to
FIG. 55 , which is a simplified pictorial illustration of a vialhead adaptor element 2030 which forms part of the drug mixing system ofFIGS. 54A-54H and toFIG. 56 which is a sectional illustration taken along section lines LVI-LVI inFIG. 55 . - As seen in
FIG. 55 , vialhead adaptor element 2030 is preferably a side-to-side symmetric integrally formed element which is preferably injection molded of plastic. - Vial
head adaptor element 2030 preferably includes amain body portion 2200 which is generally cylindrical and has acentral axis 2201. An innercylindrical surface 2202 ofmain body portion 2200 preferably has fourarms 2204 extending therefrom, eacharm 2204 being arranged at generally right angles with respect to its neighboring arms. - Each of
arms 2204 terminates at an upper end thereof, in the sense ofFIG. 54C , in an inwardly facing generallytriangular tooth 2206 having a forwardly facinginclined surface 2208 and a bottom-facingengagement surface 2210 extending generally perpendicular toarm 2204. - At bottom surface of vial
head adaptor element 2030, there are formed four inwardly protrudingsurfaces 2212, extending generally perpendicular toinner surface 2202 ofmain body portion 2200. Each of neighboringsurfaces 2212 is preferably arranged at a generally right angle with respect to its neighboringsurfaces 2212.Surfaces 2212 andarms 2204 are rotationally offset from one another aboutaxis 2201. - Reference is now made to
FIG. 57 , which is a simplified pictorial illustration of spikeport adaptor element 2030 which forms part of the drug mixing system ofFIGS. 54A-54H and toFIG. 58 which is a sectional illustration taken along section lines LVIII-LVIII inFIG. 57 . - Spike
port adaptor element 2010 preferably comprises a hollow flexibleplastic tube 2302 having associated therewith astandard clamp 2304, which is commercially available from various manufacturers, such as Qosina of Italy. - At a forward end thereof,
tube 2302 is connected to atube port 2305 of ahollow spike element 2306 which is preferably formed of plastic.Spike element 2306 is preferably formed of amain body portion 2307 which preferably defines at a forward end thereof aspike 2308, having formed therein an aperture communicating with anaxially extending bore 2310 and anadditional bore 2312 which extends partially throughmain body portion 2307 and communicates with a top portion ofbore 2310. - Rearward of
spike 2308,main body portion 2307 defines a generally circularplanar protrusion 2314 adapted to define the location at which a user grips the spike. - The interior of
tube 2302 is in fluid flow communication withbore 2312 viatube port 2305.Bore 2310 preferably terminates in an aperture located inspike 2308 ofmain body portion 2307 and fully extends through the main body portion. -
Main body portion 2307 preferably terminates in aconnection port 2318 which is adapted to connect spikeport adaptor element 2010 toreceptacle adaptor subassembly 2046.Connection port 2318 preferably sealingly accommodates a generallycircular septum 2320 on aseat 2322.Septum 2320 preferably engages the rear end ofbore 2310, thus sealing the rear end of the bore. - Forward of
connection port 2318, there is formed on main body portion 2307 acircumferential protrusion 2324, forward of which is formed an additionalcircumferential protrusion 2326, having an outer circumference which is slightly larger than that ofprotrusion 2324.Protrusions port adaptor element 2010 when it is connected toreceptacle adaptor subassembly 2044. - A
luer connector 2330 is preferably attached to a rear end oftube 2302.Luer connector 2330 preferably includes at a rearwardmost end thereof a narrowhollow port section 2332, forward of which there is formed a connectingtube portion 2334 and ahollow neck portion 2336 which is adapted to connectluer connector 2330 totube 2302. Preferably,luer connector 2330 is sealed byluer cover element 2014. - It is appreciated that spike
port adaptor element 2010 may alternatively be identical to spikeport adaptor element 630 described hereinabove with reference toFIGS. 10-11B . - Reference is now made to
FIG. 59 , which is a simplified exploded view illustration ofadaptor assembly 2040 which forms part of the drug mixing system ofFIGS. 54A-54H . - As seen with particular clarity in
FIG. 59 ,adaptor assembly 2040 comprisesvial adaptor subassembly 2044, onto which are placed ahydrophobic membrane 2402, above which is optionally seated acarbon cloth filter 2404.Vial adaptor subassembly 2044 is connected at a forward portion thereof to arear connection element 2406 ofreceptacle adaptor subassembly 2046. - A
needle holding element 2408 is preferably seated withinrear connection element 2406 and supports aneedle 2410. A forward portion ofneedle 2410 is preferably protected by a flexible latexneedle protection element 2412.Receptacle adaptor subassembly 2046 connects at a rearward end thereof torear connection element 2406, enclosingneedle holding element 2408 andneedle protection element 2412. - The forward portion of
vial adaptor subassembly 2044 as well as the rear portion ofreceptacle adaptor subassembly 2046 are located withinhousing element 2050. - Reference is now made to
FIG. 60 , which is a simplified pictorial illustration ofvial adaptor subassembly 2044 which forms part ofadaptor assembly 2040 ofFIG. 59 and toFIGS. 61A and 61B , which are sectional illustrations taken along respective section lines LXIA-LXIA and LXIB-LXIB inFIG. 60 . - As seen in
FIGS. 60-61B ,vial adaptor subassembly 2044 comprises amain body element 2502 arranged generally about anaxis 2503.Main body element 2502 is preferably integrally formed and preferably injection molded of plastic. -
Main body element 2502 is preferably side-to-side symmetric aboutaxis 2503, and preferably includes arear portion 2504, which is generally cylindrical and terminates in aforward wall 2506.Rear portion 2504 comprises aforward base section 2508, preferably having four transversely extending outwardly facingprotrusions 2509 extend therefrom, each protrusion being arranged at generally right angles with respect to its neighboring protrusions. - Rearward of
base section 2508 there are formed a plurality oftabs 2510 each having arectangular window 2512. Rearward ofrectangular windows 2512 and on aninner surface 2514 of each oftabs 2510 there are preferably formed two radially extending inwardly facingprotrusions 2516 each having an inclined surface.Protrusions 2516 preferably terminate at a forward end thereof in an inwardly facing transversely extendingprotrusion 2518. Rearward ofprotrusions 2516, each oftabs 2510 preferably includes an outwardlytapered portion 2520. - A hollow
vial puncturing spike 2522 extends rearwardly from arearward surface 2524 offorward wall 2506, and is surrounded bybase section 2508 and bytabs 2510.Rearward surface 2524 additionally includes a circularcylindrical protrusion 2525, surrounding puncturingspike 2522. Two axially extendingbores vial puncturing spike 2522. - Forward of
forward wall 2506 ofrear portion 2504 there is formed an intermediate portion which formed of two generallyrectangular surfaces 2528, and includes anaxial tubular portion 2530 having abore 2531 extend therethrough, bore 2531 being in fluid flow engagement withbore 2526 of hollowvial puncturing spike 2522. - On the top
rectangular surface 2528 and slightly recessed with respect thereto there is formed a plasticmembrane support surface 2532, having formed thereon a plurality of generally evenly distributedspherical protrusions 2534, which are adapted to supporthydrophobic membrane 2402 and prevent it from excessive inflation and from cracking.Membrane 2402 is adapted to allow free passage of air to and frommain body element 2502, but to prevent passage of liquid and air borne particles, microorganisms and aerosol. Apreferred membrane 2402 is Model Versapor R 0.2 Micron which is commercially available from Pall Corporation of New York, U.S.A. - A
narrow bore 2537 connectsmembrane 2402 to bore 2531, thus allowing pressure equalization in an evacuateddrug vial 2020 upon connection ofvial 2020 to thevial adaptor subassembly 2044. When fluid first passes through the system during drug dilution, bore 2537 irreversibly fills with liquid, thus preventing air from escaping the system. - Prevention of the escape of air from the system is necessary for the reversible transfer of liquid from the
receptacle 2012 to thevial 2020 and vice versa. Air movement betweenvial 2020 andreceptacle 2012 causes changes in pressure in the vial, thereby pushing liquid from the vial into the receptacle. - A
rim 2538 surroundingsupport surface 2532 is adapted to support an optionalcarbon cloth filter 2404 and maintain it in a raised position above and spaced frommembrane 2402.Carbon filter 2404 is adapted to prevent toxic vapors from escaping frommain body element 2502, thus protecting users. A preferredcarbon cloth filter 2404 is Model No. Zorflex EMI which is commercially available from Charcoal Cloth International Ltd. of Houghton-le-Spring, England. -
Rectangular surfaces 2528 of the intermediate portion terminate at a forward end thereof in a forward facingcylindrical portion 2548, having abore 2550 extend therethrough. Preferably, bore 2550 is a continuation oftubular portion 2530 of the intermediate portion. - It is appreciated that the functionalities of
membrane 2402 andcarbon cloth filter 2404, to allow free passage of air into the drug mixing system while preventing passage thereinto of liquid and air-borne particles, microorganisms and aerosol and preventing toxic vapors from escaping from the drug mixing system, may be incorporated, using similar elements, into anyreceptacle adaptor subassembly 2046. - Reference is now made to
FIG. 62 , which is a simplified pictorial illustration ofreceptacle adaptor subassembly 2046 which forms part of theadaptor assembly 2040 ofFIG. 59 and toFIGS. 63A and 63B , which are sectional illustrations taken along respective section lines LXIIIA-LXIIIA and LXIIIB-LXIIIB inFIG. 62 . - As seen in
FIGS. 62-63B ,receptacle adaptor subassembly 2046 includes amain body element 2600 which is arranged generally about anaxis 2601.Main body element 2600 is preferably integrally formed of plastic, and is preferably side-to-side symmetric aboutaxis 2601.Main body element 2600 preferably includes a generallycylindrical base portion 2602 terminating in arear portion 2604. - Top and bottom generally
concave wall portions 2606 are formed at a forward end ofbase portion 2602, eachwall portion 2606 defining on an outer surface thereof an outwardly facing axially extendingrib 2608, which extends from a forwardmost end of each ofwall portions 2606 and alongbase portion 2602. - A
connection surface 2610 extending transversely fromside surfaces 2612 ofbase portion 2602 connects an outwardly extendingarm 2614 to eachside surface 2612. Eacharm 2614 preferably has a generally squarerear portion 2616, formed rearwardly ofconnection surface 2610, and has a radially extending outwardly facingprotrusion 2618 formed thereon.Protrusion 2618 preferably extends onto an outer surface of a generallyrectangular forward portion 2620 of each ofarms 2614, which extends forwardly ofconnection surface 2610. - An inwardly facing generally
triangular tooth 2622 is formed adjacent a top end of each offorward portions 2620. Eachtooth 2622 preferably includes a forwardly facinginclined surface 2624 and a rearwardly facingengagement surface 2626. -
Rear portion 2604 preferably includes a transversely extending generallycircular portion 2630 which forms a base forribs 2608 and which terminates at a rear end thereof in an axially extending generallycylindrical wall portion 2632. -
Wall portion 2632 preferably defines on a top and bottom surface thereof a small generallyrectangular window 2634, and two forwardly facingslots 2636 which are formed on either side ofwindow 2634. Two generally symmetric side-facingtabs 2638 are formed onside surfaces 2640 ofwall portion 2632, eachtab 2638 being formed forwardly of a generally rectangular forwardly facingslot 2642. -
Rear connection element 2406 preferably includes aforward disk 2652 defining acentral bore 2654.Disk 2652 preferably functions as a terminating wall for a forward facingcylindrical portion 2656. Rearward ofdisk 2652 there is preferably formed arear portion 2658, having anarrow bore 2660 extend therethrough.Bore 2660 preferably widens toward the rear end ofrear portion 2658, thus enablingrear portion 2658 to connect to an appropriate port. Preferably, two generallysymmetric tabs 2662 are formed on top and bottom surfaces ofrear portion 2658.Cylindrical portion 2656 preferably has an outer circumference that is slightly smaller than that ofwall portion 2632, and is located therein. -
Needle holding element 2408 preferably supportsneedle 2410 on a generallycircular disk portion 2672.Needle 2410 extends axially throughbase portion 2602 ofmain body element 2600 and throughbore 2660 of rear connection element 2650.Disk portion 2672 is preferably seated incylindrical portion 2656, and is locked intocylindrical portion 2656 byportion 2630. - Reference is now made to
FIGS. 64A and 64B , which are simplified pictorial illustrations of thehousing element 2050 which forms part of theadaptor assembly 2040 ofFIG. 59 in closed and open orientations, respectively. - As seen in
FIGS. 64A and 64B ,housing element 2050 is preferably integrally formed about anaxis 2700 and includes atop housing portion 2701 and abottom housing portion 2702. Preferably,housing portions axis 2700. Preferably, each ofhousing portions forward portion 2704 and a semi-cylindricalrearward portion 2706. - Top and
bottom housing portions portion 2708 including a generally centralelongate protrusion 2710. -
Top housing portion 2701 includes at forward and rearward ends thereof outwardly extendingfingers 2722 terminating in a generallytriangular teeth 2724 which include inclined outwardly facingsurfaces 2726 and engagement surfaces 2728.Bottom housing portion 2702 preferably includes at forward and rearward ends thereof two generallyrectangular windows 2730 which are placed generally belowfingers 2722 and are adapted to engageengagement surfaces 2728 offingers 2722 whenhousing element 2050 is assembled. - An
inner surface 2734 ofhousing element 2050 preferably includes at a rearward end thereof acircumferential recess 2736 which is adapted to engageprotrusions 2509 ofrear portion 2504 ofvial adaptor subassembly 2044. An outer surface ofhousing element 2050 which lies aboverecess 2736 preferably includes an outwardly facingprotrusion 2740 which protrudes out of cylindricalrearward portion 2706. - Reference is now made to
FIG. 65 , which is a simplified assembled pictorial illustration of theadaptor assembly 2040 ofFIG. 59 and toFIGS. 66A and 66B , which are sectional illustrations taken along respective section lines LXVIA-LXVIA and LXVIB-LXVIB inFIG. 65 . - As seen in
FIGS. 65-66B ,rear portion 2504 ofvial adaptor subassembly 2044 extends from a rear portion ofhousing element 2050.Vial puncturing spike 2522 preferably extends out ofhousing element 2050, and is accessible for connection ofvial 2020 or of vial 2026 (FIG. 54B ) thereto. - Preferably,
circumferential recess 2736 ofinner surface 2734 ofhousing element 2050 engagesprotrusions 2509 ofrear portion 2504 ofvial adaptor subassembly 2044. Preferably, forward facingcylindrical portion 2548 engagesrear portion 2658 ofrear connection element 2406. A rear end ofneedle 2410 at least partially extends throughbore 2660 and throughbore 2550 such that bore 2550 is in fluid flow communication withneedle 2410 ofreceptacle adaptor subassembly 2046. - A forward portion of
main body element 2600 ofreceptacle adaptor subassembly 2046 preferably extends from a forward portion ofhousing element 2050 ofadaptor assembly 2040, and surroundsneedle 2410 enclosed inneedle protection element 2412.Main body element 2600 includingneedle 2410 andneedle protection cover 2412 is preferably accessible for connection of spike port adaptor element 2010 (FIGS. 57-58 ) thereto. -
Housing element 2050 is preferably assembled, such thattop housing portion 2701 andbottom housing portion 2702 are connected by engagement ofengagement surfaces 2728 ofteeth 2724 oftop housing portion 2701 andwindows 2730 ofbottom housing portion 2702. - Reference is now made to
FIGS. 67A and 67B , which are sectional illustrations of the drug mixing system ofFIG. 54B during attachment ofvial 2020 to thevial adaptor subassembly 2044 ofadaptor assembly 2040 ofFIG. 65 . -
Vial 2026 and vialhead adaptor element 2030 joined thereto (FIG. 54C ) orvial 2020 is preferably pushed into engagement withvial puncturing spike 2522 ofvial adaptor subassembly 2044. - Typically,
vial puncturing spike 2522 ofvial adaptor subassembly 2044 punctures septum 2024 located insidetop portion 2022 ofvial 2020, thus enabling fluid flow between the main body ofvial 2020 and bore 2550 ofcylindrical portion 2548 ofmain body element 2502 ofvial adaptor subassembly 2044. Preferably, puncturing ofseptum 2024 releases any vacuum invial 2020 by entrance of air intovial 2020 through optional carbon cloth filter 2404 (FIG. 61A ) and membrane 2402 (FIG. 61A ). Engagement betweenvial adaptor subassembly 2044 andvial 2010 is preferably maintained by snap engagement ofprotrusions rear portion 2504 ofmain body element 2600 withneck portion 2023 ofvial 2020. The engagement ofprotrusions neck portion 2023 ensures thatvial adaptor subassembly 2044 is latched ontovial 2020 and cannot be removed therefrom.Tabs 2510 and outwardlytapered portions 2520 generally surroundtop portion 2022 andneck portion 2023 ofvial 2020. - At this stage, the main body of
vial 2020 is in fluid flow communication withneedle 2410 viavial puncturing spike 2522, bore 2550 ofcylindrical portion 2548 and bore 2660 ofcylindrical portion 2658. - Reference is now made to
FIG. 68 , which is a sectional illustration of the drug mixing system ofFIG. 54D-54G during attachment of the receptacleport adaptor element 2010 and receptacle 2012 ofFIG. 54A to thereceptacle adaptor subassembly 2046 ofadaptor assembly 2040 ofFIG. 67 , havingvial 2020 attached thereto. - As seen in
FIG. 68 , spikeport adaptor element 2010, havingreceptacle 2012 joined thereto, is connected toreceptacle adaptor subassembly 2046 ofadaptor assembly 2040. -
Spike 2308 is preferably previously inserted intospike port 2011 ofreceptacle 2012, such that bore 2310 ofspike element 2306 engages fluid content ofreceptacle 2012.Connection port 2318 of spikeport adaptor element 2010 engageswall portions 2606 andbase portion 2602 ofmain body element 2600 ofreceptacle adaptor subassembly 2046. -
Connection port 2318 is preferably locked into connection withreceptacle adaptor subassembly 2046 by engagement ofengagement surfaces 2626 offorward portions 2620 ofawls 2614 and a rearward facing wall portion ofconnection port 2318. - Preferably,
needle 2410 punctures needleprotection cover 2412 andseptum 2320, resulting in partial collapse of the needle protection cover. At this stage,receptacle 2012 is in fluid flow communication with the main body ofvial 2020 viabore 2310 ofspike 2308 of spikeport adaptor element 2010,needle 2410, bore 2660, bore 2550 ofcylindrical portion 2548, bore 2531 oftubular portion 2530 andvial puncturing spike 2522. - Reference is now made to
FIG. 69 , which is a sectional illustration of the drug mixing system ofFIGS. 54H and 68 during disconnection of the spikeport adaptor element 2010 and receptacle 2012 from thereceptacle adaptor subassembly 2046 ofadaptor assembly 2040 ofFIG. 67 . - As shown in
FIG. 69 , spikeport adaptor element 2010 andreceptacle 2012 joined thereto are disconnected fromreceptacle adaptor subassembly 2046 ofadaptor assembly 2040. Typically, spikeport adaptor element 2010 is disconnected fromreceptacle adaptor subassembly 2046 by slightly pushingarms 2614 extending fromside surfaces 2612 ofbase portion 2602, causingteeth 2620 to move outward and release the rearward facing wall portion ofconnection port 2318, thus disconnecting the connection port. Typically,needle 2410 is released fromconnection port 2318, andneedle protection cover 2412 is deployed and once again fully enclosesneedle 2410, thus sealing it to prevent leakage. - Reference is now made to
FIG. 70 which is a simplified exploded view illustration of a drug mixing system constructed and operative in accordance with a further preferred embodiment of the present invention. The embodiment ofFIG. 70 is a modification of the embodiments ofFIGS. 31A-53 and 54A-69 . Accordingly, for the sake of conciseness, it is described hereinbelow in somewhat abbreviated faun with reference toFIGS. 71-78 . - In this embodiment the drug vial is enclosed in a protective housing used during storage and dilution, thereby preventing spills in case of breakage.
- As seen with particular clarity in
FIG. 70 , the drug mixing system comprises avial adaptor subassembly 3000, which preferably comprises an externally threadedvial support element 3010, into which is placed avial 3020. - A vial puncturing
cover assembly 3030 comprises an internally threadedcovering element 3032, which connects at a forward end thereof to the externally threaded portion ofvial support element 3010. At a top end thereof, coveringelement 3032 engages a vial puncturingspike element 3034, which supports ahydrophobic membrane 3036. - Vial puncturing
cover assembly 3030 connects at a forward end thereof to a connection port of areceptacle adaptor subassembly 3040, which is adapted to engage a spike portreceptacle adaptor element 3050. Spike portreceptacle adaptor element 3050 is preferably inserted into areceptacle port 3051 of areceptacle 3052. - Alternatively, vial puncturing
cover assembly 3030 may connect at a forward end thereof to avial port 3080 of astopcock 3082, and the connection port of receptacleport adaptor assembly 3040 connects to areceptacle port 3084 ofstopcock 3082. When this option is used, asyringe port 3086 ofstopcock 3082 preferably engages a luer fitted syringe. - It is appreciated that
vial 3020 may be identical to either ofvials receptacle 3052 may be identical toreceptacle 2012, described hereinabove with reference toFIGS. 54A-54C . -
Receptacle adaptor subassembly 3040 may be identical toreceptacle adaptor subassembly 2046, described hereinabove with reference toFIGS. 62-63B . - Spike
port adaptor element 3050 may be identical to spikeport adaptor element 2010, described hereinabove with reference toFIGS. 57-58 . - Reference is now made to
FIG. 71 which is a simplified pictorial illustration of avial support element 3010 which forms part ofvial adaptor subassembly 3000 of the drug mixing system ofFIG. 70 and toFIGS. 72A and 72B which are, respectively, a sectional illustration and a pictorial sectional illustration taken along section lines LXXII-LXXII inFIG. 71 . -
Vial support element 3010 comprises a generallycylindrical body element 3100 arranged generally about anaxis 3101.Body element 3100 is preferably integrally formed and preferably is generally side-to-side symmetric aboutaxis 3101. -
Body element 3100 preferably includes atop portion 3102, which is externally threaded and which is separated from abottom portion 3104 by an outwardly facingcircumferential protrusion 3106. Four axially extending outwardly facingprotrusions 3108 are preferably formed onbottom portion 3104, eachprotrusion 3108 being arranged at generally right angles with respect to its neighboring protrusions. -
Body element 3100 preferably terminates in a transversely extendingbase wall portion 3110, which includes a centralspherical protrusion 3112 which is adapted tocenter vial 3020 invial support element 3010. - As seen with particular clarity in
FIG. 72B , aninner surface 3114 ofbody element 3100 may optionally include a plurality of axially extending inwardly facing generallyrectangular protrusions 3116, which are operative to adaptvial support element 3010 to support a smaller vial.Different body elements 3100, molded withprotrusions 3116 of different sizes, may be used for different vial sizes. Similarly,base wall portion 3110 may optionally be molded at various heights with respect tobottom portion 3104, thus enabling differentvial support elements 3010 to support vials of different heights. - Reference is now made to
FIG. 73 , which is a simplified pictorial illustration ofvial support element 3010 ofFIGS. 71-72B containing avial 3020 and toFIG. 74 , which is a sectional illustration taken along section lines LXXIV-LXXIV inFIG. 73 . - As seen in
FIGS. 73 and 74 ,vial 3020 is placed withinvial support element 3010, such thattop portion 3022,septum 3024 and at least part ofneck portion 3023 extend above the vial support element and are accessible to a user. - A base of
vial 3020 is preferably seated onbase wall portion 3110 and engagesspherical protrusion 3112. - Reference is now made to
FIGS. 75A and 75B , which are simplified pictorial illustrations of vial puncturingcover assembly 3030 which forms part of thevial adaptor subassembly 3000 ofFIG. 70 and toFIG. 76 which is a sectional illustration taken along section lines LXXVI-LXXVI inFIG. 75A . - Vial puncturing
cover assembly 3030 includes coveringelement 3032, which comprises a generally cylindricalmain body portion 3202 arranged generally about anaxis 3203. -
Main body portion 3202 is preferably internally threaded and is adapted to engage the externally threadedtop portion 3102 ofvial support element 3010. Four axially extending outwardly facingprotrusions 3204 are preferably formed on anouter surface 3205 ofmain body portion 3202, eachprotrusion 3204 being arranged at generally right angles with respect to its neighboring protrusions. An outwardly facing radially extendingwall portion 3206 extends from a bottom end ofmain body portion 3202. -
Main body portion 3202 terminates in awall portion 3208, which preferably extends transversely with respect toaxis 3203 and includes a generallyround aperture 3210. Aninner surface 3212 ofwall portion 3208 preferably includes twosemi-circular tracks 3214. - Vial puncturing
spike element 3034 preferably includes avial puncturing spike 3220 extending throughaperture 3210 ofwall portion 3208.Vial puncturing spike 3220 preferably has twoaxial bores 3222 and 3224 extending therethrough. - Preferably
membrane 3036 is in fluid flow engagement withcover element 3032 via bore 3224 ofvial puncturing spike 3220. -
Spike 3220 preferably extends forwardly from a generallycircular wall portion 3226, which engages a top surface ofwall portion 3208. Four generallyrectangular wall portions 3228 extend radially fromspike 3220, eachwall portion 3228 being arranged at generally right angles with respect to its neighboring wall portions. -
Wall portions 3228 preferably define at top surfaces thereof fourspherical protrusions 3230, which engagetracks 3214 and are adapted to lock vial puncturingspike element 3034 with respect to coveringelement 3032. - A generally
cylindrical portion 3232, including anaxial bore 3234, preferably extends rearwardly fromwall portion 3226.Cylindrical portion 3232 is preferably adapted to engagerear portion 3658 ofreceptacle adaptor subassembly 3040. - A second generally
cylindrical portion 3236 preferably extends rearwardly ofwall portion 3226 and adjacentcylindrical portion 3232.Portion 3236 preferably defines aseat 3238 which is adapted to supportunidirectional breathing membrane 3036 and prevent it from excessive inflation and from cracking.Membrane 3036 is adapted to allow free passage of air into themain body element 3032, but prevent passage therethrough of liquid and air-borne particles, microorganisms and aerosol. Apreferred membrane 3036 is Model Versapor R 0.2 Micron which is commercially available from Pall Corporation of New York, U.S.A. - Reference is now made to
FIG. 77 , which is a simplified assembled pictorial illustration of thevial adaptor subassembly 3000 ofFIG. 70 and toFIG. 78 , which is a sectional illustration taken along section lines LXXVIII-LXXVIII inFIG. 77 . - As seen in
FIGS. 77 and 78 , vial puncturingcover assembly 3030 threadably engagesvial support element 3010, thus enclosing thereinvial 3020. - The threaded engagement between
vial support element 3010 and vial puncturingcover element 3032causes puncturing spike 3220 to be pushed into engagement withvial 3020. - Typically,
vial puncturing spike 3220 of vial puncturingcover element 3030 punctures septum 3024 located insidetop portion 3022 ofvial 3020, thus enabling fluid flow between the main body ofvial 3020 and bore 3234 ofcylindrical portion 3232 viabore 3222 of puncturingspike 3220. Preferably, puncturing ofseptum 3024 releases any vacuum invial 3020. - Reference is now made to
FIG. 79 , which is a pictorial illustration of thevial adaptor subassembly 3000 ofFIG. 77 when assembled toreceptacle adaptor subassembly 3040 thus forming an adaptor assembly in accordance with a preferred embodiment of the present invention, and toFIG. 80 , which is a sectional illustration taken along section lines LXXX-LXXX inFIG. 79 . - As seen in
FIGS. 79 and 80 ,cylindrical portion 3232 ofvial cover element 3030 engagesrear portion 3658 ofreceptacle adaptor subassembly 3040. A rear end ofneedle 3410 at least partially extends throughbore 3660 and throughbore 3234 such that bore 3234 is in fluid flow communication withneedle 3410 ofreceptacle adaptor subassembly 3040. Due to fluid flow communication betweenbore 3234 and the main body ofvial 3020,needle 3410 is in fluid flow communication withvial 3020. - A forward portion of
main body element 3414 ofreceptacle adaptor subassembly 3040 preferably surroundsneedle 3410 enclosed inneedle protection element 3412. Main body element 3600 includingneedle 3410 andneedle protection cover 3412 is preferably accessible for connection of spikeport adaptor element 3050 thereto. - It is appreciated that
cylindrical portion 3232 ofvial cover element 3030 may alternatively engage astopcock 3052, which additionally engagesreceptacle adaptor subassembly 3040 and a syringe as described hereinabove with reference toFIGS. 31A-53 . In such a case, the method of use of the system would be similar to that described inFIGS. 31A-31L . - Reference is now made to
FIG. 81 , which is a pictorial illustration ofvial adaptor subassembly 3000 connected toreceptacle adaptor subassembly 3040 ofFIG. 79 when connected to a spikeport adaptor element 3050 andreceptacle 3052 and to FIG. 82, which is a sectional illustration taken along section lines DOM-DOOM inFIG. 81 . - As seen in
FIGS. 81 and 82 , spikeport adaptor element 3050, havingreceptacle 3052 joined thereto, is connected toreceptacle adaptor subassembly 3040. - A
spike 3308 is preferably previously inserted intospike port 3051 ofreceptacle 3052, such that abore 3310 of aspike element 3306 engages fluid content ofreceptacle 3052. Aconnection port 3318 of spikeport adaptor element 3050 engageswall portions 3606 andbase portion 3602 ofmain body element 3414 ofreceptacle adaptor subassembly 3040. -
Connection port 3318 is preferably locked into connection withreceptacle adaptor subassembly 3040 by engagement ofengagement surfaces 3626 offorward portions 3620 ofarms 3614 and a rearward facing wall portion ofconnection port 3318. - Preferably,
needle 3410 punctures needleprotection cover 3412 andseptum 3320, resulting in partial collapse of the needle protection cover. At this stage,receptacle 3052 is in fluid flow communication with the main body ofvial 3020 viabore 3310 ofspike 3308 of spikeport adaptor element 3050,needle 3410, bore 3660, bore 3234 ofcylindrical portion 3232 andvial puncturing spike 3220. - Reference is now made to
FIG. 83 , which is a simplified exploded view illustration of a drug mixing system constructed and operative in accordance with a still further preferred embodiment of the present invention. The embodiment ofFIG. 83 is a modification of the embodiment ofFIGS. 54A-69 . Accordingly, for the sake of conciseness, it is described hereinbelow in somewhat abbreviated form with reference toFIGS. 84-92 . - As seen with particular clarity in
FIG. 83 , the drug mixing system comprises areceptacle adaptor subassembly 4000 which preferably comprises a receptacleadaptor housing element 4010. Receptacleadaptor housing element 4010 preferably engages a receptacleadaptor needle assembly 4020.Receptacle adaptor subassembly 4000 preferably engages a port such as areceptacle port 4031 of areceptacle 4032. - Receptacle
adaptor needle assembly 4020 connects at a rearward end thereof to a connection port of avial adaptor subassembly 4040, which is adapted to engage avial 4050. - It is appreciated that
vial 4050 may be identical to either ofvials receptacle 4032 may be identical to receptacle 2032, described hereinabove with reference toFIGS. 54A-54C . -
Vial adaptor subassembly 4040 may be identical tovial adaptor subassembly 2046, described hereinabove with reference toFIGS. 60-61B . -
Receptacle port 4031 may be identical receptacle port 2031, described hereinabove. It is appreciated thatreceptacle adaptor subassembly 4000 may engage a spike port adaptor element such as spikeport adaptor element 2030 described hereinabove with reference toFIGS. 57-58 . - Reference is now made to
FIG. 84 , which is a simplified pictorial illustration of receptacleadaptor housing element 4010 which fauns part of the drug mixing system ofFIG. 83 and toFIGS. 85A and 85B , which are sectional illustrations taken along section lines LXXXVA-LXXXVA and LXXXVB-LXXXVB inFIG. 84 . - Receptacle
adaptor housing element 4010 comprises abody element 4100, arranged generally about anaxis 4101.Body element 4100 comprises a tube of generally rectangular cross-section, is preferably integrally formed and preferably is generally side-to-side symmetric aboutaxis 4101. -
Body element 4100 preferably includes arear portion 4102 which is formed withribbed grip regions 4104 on anouter surface 4106. Twoelongate windows 4108 are preferably formed on top and bottom surfaces ofrear portion 4102. - A
forward portion 4110 ofbody element 4100 has a slightly smaller outer circumference than that ofrear portion 4102, and includes a generallyrectangular window 4112 on each of the surfaces thereof.Forward portion 4110 preferably sealingly accommodates aseptum 4114 in aseat 4116. - Four axially extending
tabs 4118 extend forwardly offorward portion 4110, eachtab 4118 being arranged at generally right angles with respect to its neighboring tabs. Eachtab 4118 preferably includes and an inwardly facingtooth 4120 and preferably terminates in an outwardlytapered portion 4122. - Reference is now made to
FIG. 86 , which is a simplified pictorial illustration of receptacleadaptor needle assembly 4020 which forms part of the drug mixing system ofFIG. 83 and toFIGS. 87A and 87B , which are sectional illustrations taken along section lines LXXXVIIA-LXXXVIIA and LXXXVIIB-LXXXVIIB inFIG. 86 . - Receptacle
adaptor needle assembly 4020 comprises a generallycylindrical body element 4200, arranged generally about anaxis 4201.Body element 4200 is preferably integrally formed and preferably is generally side-to-side symmetric aboutaxis 4201. -
Body element 4200 preferably includes arear connection port 4202 which is separated from aforward portion 4204 by a circumferential outwardly extendingprotrusion 4206.Protrusion 4206 is adapted to limit the extent to which receptacleadaptor needle assembly 4020 is inserted into receptacleadaptor housing element 4010. -
Forward portion 4204 preferably terminates in aforward wall portion 4205 from which extends acylindrical portion 4210 having an outer circumference which is slightly larger than that offorward portion 4204.Cylindrical portion 4210 preferably has formed thereon four axially extendingprotrusions 4212, eachprotrusion 4212 being arranged at generally right angles with respect to its neighboring protrusions. - Two outwardly extending
arms 4214 are formed at a forward end ofcylindrical portion 4210, each aim 4214 being generally across from the other arm.Protrusions 4212 andarms 4214 are preferably rotationally offset from one another aboutaxis 4201. Eacharm 4214 preferably defines at a forward most end thereof a generallytriangular tooth 4216 including anengagement surface 4218. - A
hollow needle 4220 is preferably sealingly mounted in acylindrical portion 4222 which is formed withincylindrical portion 4210 of receptacleadaptor needle assembly 4020. - Reference is now made to
FIG. 88 , which is a simplified assembled pictorial illustration of thereceptacle adaptor subassembly 4000 ofFIG. 83 and toFIGS. 89A and 89B ,which are sectional illustrations taken along section lines LXXXIXA-LXXXIXA and LXXXIXB-LXXXIXB inFIG. 88 . - As seen in
FIG. 88-89B ,cylindrical portion 4210 of receptacleadaptor needle assembly 4020 preferably engages a rearwardmost portion ofrear portion 4102 of receptacleadaptor housing element 4010.Teeth 4216 ofarms 4214 ofcylindrical portion 4210 preferably extend throughwindows 4108 and maintain receptacleadaptor needle assembly 4020 locked in receptacleadaptor housing element 4010. - It is appreciated that a user may push receptacle
adaptor needle assembly 4020 inward with respect to receptacleadaptor housing element 4010. Such inward motion of receptacleadaptor needle assembly 4020 is limited byprotrusion 4206. - Reference is now made to
FIG. 90 , which is a pictorial illustration of thereceptacle adaptor subassembly 4000 ofFIG. 88 when assembled to avial adaptor subassembly 4040 and toport 4031 ofreceptacle 4032, prior to insertion ofneedle 4220 into thereceptacle port 4031 and toFIG. 91 , which is a sectional illustration taken along section lines XCI-XCI inFIG. 90 . -
Vial 4050 is preferably pushed into engagement with avial puncturing spike 4522 ofvial adaptor subassembly 4040. - Typically,
vial puncturing spike 4522 ofvial adaptor subassembly 4050 punctures aseptum 4014 located inside atop portion 4012 ofvial 4050, thus enabling fluid flow between the main body ofvial 4050 and abore 4550 of acylindrical portion 4548 ofmain body element 4502 ofvial adaptor subassembly 4050. Preferably, puncturing ofseptum 4014 releases any vacuum invial 4050 by entrance of air intovial 4050 through acarbon filter 4404 and amembrane 4402. - Engagement between
vial adaptor subassembly 4040 andvial 4050 is preferably maintained by snap engagement ofprotrusions main body element 4502 withneck portion 4013 ofvial 4050. The engagement ofprotrusions neck portion 4013 ensures thatvial adaptor subassembly 4040 is latched ontovial 4050 and cannot be removed therefrom.Tabs 4510 and outwardlytapered portions 4520 generally surroundtop portion 4012 andneck portion 4013 ofvial 4050. -
Cylindrical portion 4548 preferably engagesconnection port 4202 of receptacleadaptor needle assembly 4020, such thatneedle 4220 is in fluid flow communication withvial 4050 viaforward portion 4204, bore 4550 ofcylindrical portion 4548 andvial puncturing spike 4522. The sharpened tip ofneedle 4220 preferably partially extends throughseptum 4114. -
Teeth 4120 ofarms 4118 preferably engagereceptacle port 4031 ofreceptacle 4032, or may alternatively engage any other suitable port such as a spike port adaptor element 4030 as described hereinabove. - Reference is now made to
FIG. 92 , which is a pictorial illustration of thereceptacle adaptor subassembly 4000 ofFIG. 88 when assembled to avial adaptor subassembly 4040 and toport 4031 ofreceptacle 4032, following insertion ofneedle 4220 intoreceptacle port 4031 and toFIG. 93 , which is a sectional illustration taken along section lines XCIII-XCIII inFIG. 92 . - As seen in
FIGS. 92 and 93 , a user preferably pushes receptacleadaptor needle assembly 4020 inward, such thatneedle 4220 piercesseptum 4114, resulting in fluid flow communication betweenreceptacle 4032 andvial 4050. - It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described hereinabove. Rather the scope of the present invention includes both combinations and subcombinations of various features described hereinabove as well as modifications thereof which would occur to persons skilled in the art upon reading the foregoing specification and which are not in the prior art.
Claims (9)
1-63. (canceled)
64. A method comprising:
attaching a luer fitted hypodermic syringe having a plunger to a syringe adaptor;
connecting said syringe adaptor having said syringe attached thereto, to a vial adaptor, having a drug containing vial attached thereto;
retracting said plunger, thus drawing a part of the contents of said vial into said syringe;
storing the drug left in the vial by storing the vial and vial adaptor joined thereto in a suitable facility for further use,
the vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of said vial.
65. The method according to claim 64 , wherein the suitable facility is a cooling facility.
66. The method according to claim 64 , wherein the vial adaptor comprises:
a spike adapted for penetrating said vial;
a mechanical lock for locking said vial adaptor to said vial once said spike penetrates said vial; and
a membrane vent operative to vent said vial adaptor to the atmosphere.
67. The method according, to claim 66 , wherein the membrane vent includes a filter and a hydrophobic membrane.
68. The method according to claim 66 , wherein mechanical lock irreversibly locks said vial adaptor to said vial.
69. The method according to claim 64 , further comprising:
pushing said plunger, thus injecting said part of the contents of said vial into an infusion
70. The method according to claim 64 , farther comprising:
inserting a receptacle port adaptor into a port in a receptacle containing a fluid;
connecting said syringe adaptor having said syringe attached thereto, to said receptacle port adaptor; and
pushing said plunger, thus injecting said part of the contents of said vial into said receptacle.
71. A method for handling a drug formulation comprising:
attaching a vial adaptor to a vial containing the drug formulation;
attaching at least one syringe adaptor having a syringe port to said vial adaptor, at least one of said syringe adaptor and said vial adaptor being vented to the outside atmosphere via a filter which prevents vapors of said drug formulation from escaping to the outside atmosphere and prevents micro-organisms and contaminants from the outside atmosphere from reaching an interior of said vial, said vial adaptor and said at least one syringe adaptor;
attaching a syringe, to said syringe port;
following withdrawal at least some of said drug formulation from said vial, storing a remainder of said drug formulation in said vial having said at vial adaptor attached thereto.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/175,385 US20170021156A1 (en) | 2003-10-30 | 2016-06-07 | Safety drug handling device |
US15/806,654 US10953216B2 (en) | 2003-10-30 | 2017-11-08 | Safety drug handling device |
US17/181,452 US11224730B2 (en) | 2003-10-30 | 2021-02-22 | Safely drug handling device |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51661303P | 2003-10-30 | 2003-10-30 | |
US10/577,618 US8122923B2 (en) | 2003-10-30 | 2004-10-29 | Safety drug handling device |
PCT/IL2004/000993 WO2005041846A2 (en) | 2003-10-30 | 2004-10-29 | Safety drug handling device |
US13/357,004 US8511352B2 (en) | 2003-10-30 | 2012-01-24 | Safety drug handling device |
US13/955,375 US9532927B2 (en) | 2003-10-30 | 2013-07-31 | Safety drug handling device |
US15/175,385 US20170021156A1 (en) | 2003-10-30 | 2016-06-07 | Safety drug handling device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/955,375 Continuation US9532927B2 (en) | 2003-10-30 | 2013-07-31 | Safety drug handling device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/806,654 Continuation US10953216B2 (en) | 2003-10-30 | 2017-11-08 | Safety drug handling device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20170021156A1 true US20170021156A1 (en) | 2017-01-26 |
Family
ID=34549555
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/577,618 Active 2028-07-29 US8122923B2 (en) | 2003-10-30 | 2004-10-29 | Safety drug handling device |
US13/357,004 Active US8511352B2 (en) | 2003-10-30 | 2012-01-24 | Safety drug handling device |
US13/854,348 Active 2025-10-02 US9345641B2 (en) | 2003-10-30 | 2013-04-01 | Safety drug handling device |
US13/955,375 Active 2025-08-23 US9532927B2 (en) | 2003-10-30 | 2013-07-31 | Safety drug handling device |
US15/143,845 Active US9549875B2 (en) | 2003-10-30 | 2016-05-02 | Safety drug handling device |
US15/175,385 Abandoned US20170021156A1 (en) | 2003-10-30 | 2016-06-07 | Safety drug handling device |
US15/806,654 Active 2025-08-02 US10953216B2 (en) | 2003-10-30 | 2017-11-08 | Safety drug handling device |
US17/181,452 Active US11224730B2 (en) | 2003-10-30 | 2021-02-22 | Safely drug handling device |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/577,618 Active 2028-07-29 US8122923B2 (en) | 2003-10-30 | 2004-10-29 | Safety drug handling device |
US13/357,004 Active US8511352B2 (en) | 2003-10-30 | 2012-01-24 | Safety drug handling device |
US13/854,348 Active 2025-10-02 US9345641B2 (en) | 2003-10-30 | 2013-04-01 | Safety drug handling device |
US13/955,375 Active 2025-08-23 US9532927B2 (en) | 2003-10-30 | 2013-07-31 | Safety drug handling device |
US15/143,845 Active US9549875B2 (en) | 2003-10-30 | 2016-05-02 | Safety drug handling device |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/806,654 Active 2025-08-02 US10953216B2 (en) | 2003-10-30 | 2017-11-08 | Safety drug handling device |
US17/181,452 Active US11224730B2 (en) | 2003-10-30 | 2021-02-22 | Safely drug handling device |
Country Status (16)
Country | Link |
---|---|
US (8) | US8122923B2 (en) |
EP (4) | EP2463201B1 (en) |
JP (3) | JP4740146B2 (en) |
CN (1) | CN1886295B (en) |
CA (2) | CA2792014C (en) |
DK (2) | DK2664550T3 (en) |
ES (2) | ES2461190T3 (en) |
HK (1) | HK1094563A1 (en) |
HU (1) | HUE046864T2 (en) |
IL (1) | IL174838A (en) |
IN (1) | IN2014MN00187A (en) |
PL (1) | PL2463201T3 (en) |
PT (1) | PT2463201E (en) |
RU (1) | RU2355377C2 (en) |
SI (2) | SI2664550T1 (en) |
WO (1) | WO2005041846A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11224555B2 (en) | 2018-04-23 | 2022-01-18 | Hospira, Inc. | Access and vapor containment system for a drug vial and method of making and using same |
Families Citing this family (245)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1886295B (en) * | 2003-10-30 | 2010-05-26 | 泰瓦医学有限公司 | Drug mixing system and drug mixing method |
HK1077154A2 (en) | 2003-12-30 | 2006-02-03 | Vasogen Ireland Ltd | Valve assembly |
EP1733749A4 (en) * | 2004-04-07 | 2013-09-04 | Jms Co Ltd | Syringe with connector, connector for syringe, and syringe |
JP2008518719A (en) | 2004-11-05 | 2008-06-05 | アイシーユー メディカル インコーポレイテッド | Medical soft grip connector |
US20060213793A1 (en) * | 2005-03-08 | 2006-09-28 | Christopher Brand | Syringe needle protector |
US8603039B2 (en) | 2005-03-08 | 2013-12-10 | Christopher Brand | Syringe protector |
US7905868B2 (en) | 2006-08-23 | 2011-03-15 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
US7998134B2 (en) | 2007-05-16 | 2011-08-16 | Icu Medical, Inc. | Medical connector |
US20070088294A1 (en) | 2005-07-06 | 2007-04-19 | Fangrow Thomas F Jr | Medical connector with closeable male luer |
JP2009513294A (en) * | 2005-10-30 | 2009-04-02 | メディモップ・メディカル・プロジェクツ・リミテッド | Needleless additive control valve |
US7547300B2 (en) | 2006-04-12 | 2009-06-16 | Icu Medical, Inc. | Vial adaptor for regulating pressure |
CA2650966C (en) * | 2006-05-04 | 2014-11-18 | Industrie Borla S.P.A. | Vented infusion access device |
US9295790B2 (en) * | 2006-05-05 | 2016-03-29 | Retractable Technologies, Inc. | Syringe with recessed nose and protective guard for use with frontal attachments |
ES2425579T3 (en) * | 2006-05-25 | 2013-10-16 | Bayer Healthcare, Llc | Reconstitution device |
EP2054008B1 (en) * | 2006-08-18 | 2012-01-11 | Medingo Ltd. | Methods and devices for delivering fluid to a reservoir of a fluid delivery device |
US8105314B2 (en) | 2006-10-25 | 2012-01-31 | Icu Medical, Inc. | Medical connector |
US8002756B2 (en) | 2006-12-08 | 2011-08-23 | Becton, Dickinson And Company | Method and apparatus for delivering a therapeutic substance through an injection port |
JP4894524B2 (en) * | 2007-01-15 | 2012-03-14 | ニプロ株式会社 | Simple dispensing tool |
CA2681912C (en) | 2007-02-27 | 2015-09-29 | Deka Products Limited Partnership | Hemodialysis systems and methods |
US8409441B2 (en) | 2007-02-27 | 2013-04-02 | Deka Products Limited Partnership | Blood treatment systems and methods |
US10463774B2 (en) | 2007-02-27 | 2019-11-05 | Deka Products Limited Partnership | Control systems and methods for blood or fluid handling medical devices |
US8042563B2 (en) | 2007-02-27 | 2011-10-25 | Deka Products Limited Partnership | Cassette system integrated apparatus |
US9517295B2 (en) | 2007-02-27 | 2016-12-13 | Deka Products Limited Partnership | Blood treatment systems and methods |
US8562834B2 (en) | 2007-02-27 | 2013-10-22 | Deka Products Limited Partnership | Modular assembly for a portable hemodialysis system |
US7883499B2 (en) | 2007-03-09 | 2011-02-08 | Icu Medical, Inc. | Vial adaptors and vials for regulating pressure |
IL182605A0 (en) | 2007-04-17 | 2007-07-24 | Medimop Medical Projects Ltd | Fluid control device with manually depressed actuator |
BRPI0810542A2 (en) | 2007-04-23 | 2014-10-21 | Plastmed Ltd | METHOD FOR TRANSFER WITHOUT LIQUID CONTAMINATION, FLUID TRANSFER APPARATUS, EQUIPMENT COUPLING METHOD, CONNECTOR SECTION FOR USE IN A FLUID TRANSFER OPERATION AND CONNECTION SECTION COUPLING METHOD |
US8147477B2 (en) | 2007-04-27 | 2012-04-03 | Amylin Pharmaceuticals, Inc. | Mixing tool |
WO2008136845A2 (en) | 2007-04-30 | 2008-11-13 | Medtronic Minimed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
US7963954B2 (en) | 2007-04-30 | 2011-06-21 | Medtronic Minimed, Inc. | Automated filling systems and methods |
ES2595805T3 (en) * | 2007-05-08 | 2017-01-03 | Carmel Pharma Ab | Fluid transfer device |
EP2188004A4 (en) * | 2007-08-21 | 2015-06-17 | Yukon Medical Llc | Vial access and injection system |
WO2009038860A2 (en) | 2007-09-18 | 2009-03-26 | Medeq Llc | Medicament mixing and injection apparatus |
IL186290A0 (en) * | 2007-09-25 | 2008-01-20 | Medimop Medical Projects Ltd | Liquid drug delivery devices for use with syringe having widened distal tip |
WO2009044401A2 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
CA2702385C (en) * | 2007-10-12 | 2017-07-18 | Deka Products Limited Partnership | Apparatus and methods for hemodialysis |
US9039673B2 (en) * | 2008-01-09 | 2015-05-26 | Novartis Ag | Unitary withdrawal spike unit suitable for factory fitting |
PT2231100E (en) * | 2008-01-17 | 2012-01-24 | Teva Medical Ltd | Syringe adapter element in drug mixing system |
US9248225B2 (en) | 2008-01-23 | 2016-02-02 | Deka Products Limited Partnership | Medical treatment system and methods using a plurality of fluid lines |
CA2715894C (en) * | 2008-02-18 | 2014-10-14 | Icu Medical, Inc. | Vial adaptor |
DE102008002800A1 (en) * | 2008-03-10 | 2009-09-24 | Süddeutsche Feinmechanik GmbH | mixing device |
EP2271387B1 (en) * | 2008-04-01 | 2016-06-15 | Yukon Medical, LLC | Dual container fluid transfer device |
US8414554B2 (en) * | 2008-05-14 | 2013-04-09 | J & J Solutions, Inc. | Systems and methods for safe medicament transport |
AU2014280875B2 (en) * | 2008-05-14 | 2016-06-23 | J&J Solutions, Inc. | Systems and methods for safe medicament transport |
WO2010022095A1 (en) | 2008-08-20 | 2010-02-25 | Icu Medical, Inc. | Anti-reflux vial adaptors |
CN102196798B (en) * | 2008-11-25 | 2014-04-09 | 株式会社Jms | Connector |
JP5495006B2 (en) * | 2008-11-25 | 2014-05-21 | 株式会社ジェイ・エム・エス | connector |
WO2010061743A1 (en) * | 2008-11-25 | 2010-06-03 | 株式会社ジェイ・エム・エス | Connector |
US9168366B2 (en) | 2008-12-19 | 2015-10-27 | Icu Medical, Inc. | Medical connector with closeable luer connector |
US8512309B2 (en) | 2009-01-15 | 2013-08-20 | Teva Medical Ltd. | Vial adapter element |
CA2753142C (en) * | 2009-02-24 | 2017-08-29 | Eli Shemesh | Vial adapter assembly in drug mixing system |
US8864725B2 (en) | 2009-03-17 | 2014-10-21 | Baxter Corporation Englewood | Hazardous drug handling system, apparatus and method |
US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
EP3124007A1 (en) * | 2009-04-14 | 2017-02-01 | Yukon Medical, LLC | Fluid transfer device |
US8628509B2 (en) * | 2009-05-11 | 2014-01-14 | Abbott Laboratories | Enteral connectors and systems |
DE102009023676B4 (en) * | 2009-06-03 | 2016-01-07 | Jan Willem Marinus Mijers | Device for the application of fluid medicaments |
JP5636645B2 (en) | 2009-07-03 | 2014-12-10 | ニプロ株式会社 | Chemical liquid transfer device |
EP2459146B1 (en) | 2009-07-29 | 2020-04-29 | ICU Medical, Inc. | Fluid transfer methods |
US8323249B2 (en) | 2009-08-14 | 2012-12-04 | The Regents Of The University Of Michigan | Integrated vascular delivery system |
IL200547A (en) | 2009-08-23 | 2014-06-30 | Eli Shemesh | Multiple vial drug mixing system |
US8651305B1 (en) | 2009-09-30 | 2014-02-18 | Simplified Dosing Incorporated | Reclosable container closure |
IL201323A0 (en) | 2009-10-01 | 2010-05-31 | Medimop Medical Projects Ltd | Fluid transfer device for assembling a vial with pre-attached female connector |
IL202069A0 (en) | 2009-11-12 | 2010-06-16 | Medimop Medical Projects Ltd | Fluid transfer device with sealing arrangement |
IL202070A0 (en) | 2009-11-12 | 2010-06-16 | Medimop Medical Projects Ltd | Inline liquid drug medical device |
JPWO2011068190A1 (en) * | 2009-12-04 | 2013-04-18 | テルモ株式会社 | Vial adapter |
US9750896B2 (en) * | 2010-02-05 | 2017-09-05 | Deka Products Limited Partnership | Infusion pump apparatus, method and system |
BR112012020829B1 (en) | 2010-02-24 | 2020-04-14 | Medimop Medical Projects Ltd | liquid drug transfer device for use with a medical bottle |
CN102711712B (en) * | 2010-02-24 | 2014-08-13 | 麦迪麦珀医疗工程有限公司 | Fluid transfer assembly with venting arrangement |
CH702815A1 (en) * | 2010-03-10 | 2011-09-15 | Medmix Systems Ag | Filling device for filling at least one first reservoir of an applicator. |
USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
US8771230B2 (en) | 2010-05-19 | 2014-07-08 | Tangent Medical Technologies, Llc | Integrated vascular delivery system |
WO2011146772A1 (en) | 2010-05-19 | 2011-11-24 | Tangent Medical Technologies Llc | Safety needle system operable with a medical device |
AU2011258371B2 (en) * | 2010-05-27 | 2014-09-18 | J&J Solutions, Inc. | Closed fluid transfer system |
AU2014277764B2 (en) * | 2010-05-27 | 2016-04-21 | J&J Solutions, Inc. | Closed fluid transfer system |
USD655017S1 (en) | 2010-06-17 | 2012-02-28 | Yukon Medical, Llc | Shroud |
USD669980S1 (en) | 2010-10-15 | 2012-10-30 | Medimop Medical Projects Ltd. | Vented vial adapter |
IL209290A0 (en) | 2010-11-14 | 2011-01-31 | Medimop Medical Projects Ltd | Inline liquid drug medical device having rotary flow control member |
ES2593266T3 (en) * | 2011-03-04 | 2016-12-07 | Duoject Medical Systems, Inc. | Easy connection transfer system |
PL2510914T3 (en) * | 2011-04-12 | 2015-02-27 | Hoffmann La Roche | Connector device |
IL212420A0 (en) | 2011-04-17 | 2011-06-30 | Medimop Medical Projects Ltd | Liquid drug transfer assembly |
CA3166031A1 (en) | 2011-05-24 | 2012-11-29 | Deka Products Limited Partnership | Hemodialysis system |
ES2934668T3 (en) | 2011-08-18 | 2023-02-23 | Icu Medical Inc | Pressure Regulating Vial Adapters |
USD681230S1 (en) | 2011-09-08 | 2013-04-30 | Yukon Medical, Llc | Shroud |
JP6553357B2 (en) | 2011-09-09 | 2019-07-31 | アイシーユー・メディカル・インコーポレーテッド | Medical connector with fluid-resistant mating interface |
IL215699A0 (en) | 2011-10-11 | 2011-12-29 | Medimop Medical Projects Ltd | Liquid drug reconstitution assemblage for use with iv bag and drug vial |
AU2012324021A1 (en) | 2011-12-22 | 2013-07-11 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
WO2013106757A1 (en) | 2012-01-13 | 2013-07-18 | Icu Medical, Inc. | Pressure-regulating vial adaptors and methods |
MX358074B (en) | 2012-02-02 | 2018-08-03 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling with a medical container. |
SG192310A1 (en) | 2012-02-02 | 2013-08-30 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling to a medical container |
SG192312A1 (en) * | 2012-02-02 | 2013-08-30 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling to a medical container |
WO2013119823A1 (en) * | 2012-02-07 | 2013-08-15 | Yukon Medical, Llc | Transfer device with fluid filter |
USD737436S1 (en) | 2012-02-13 | 2015-08-25 | Medimop Medical Projects Ltd. | Liquid drug reconstitution assembly |
USD720451S1 (en) | 2012-02-13 | 2014-12-30 | Medimop Medical Projects Ltd. | Liquid drug transfer assembly |
USD674088S1 (en) | 2012-02-13 | 2013-01-08 | Medimop Medical Projects Ltd. | Vial adapter |
EP2819633B1 (en) * | 2012-03-01 | 2016-06-29 | Becton, Dickinson and Company Ltd. | Pressure equalizing device and receptacle |
US9737686B2 (en) * | 2012-03-12 | 2017-08-22 | Becton, Dickinson And Company | Catheter adapter port valve |
AU2013204180B2 (en) | 2012-03-22 | 2016-07-21 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
IL219065A0 (en) | 2012-04-05 | 2012-07-31 | Medimop Medical Projects Ltd | Fluid transfer device with manual operated cartridge release arrangement |
US9956138B2 (en) | 2012-05-21 | 2018-05-01 | Carmel Pharma Ab | Protective cap |
US20160066563A1 (en) * | 2012-06-07 | 2016-03-10 | David Moscatello | Compositions and methods for collecting, washing, cryopreserving, recovering and return of lipoaspirates to physician for autologous adipose transfer procedures |
USD769444S1 (en) | 2012-06-28 | 2016-10-18 | Yukon Medical, Llc | Adapter device |
CA2783251A1 (en) * | 2012-07-17 | 2014-01-17 | Duoject Medical Systems Inc. | Reconstitution device with tip cap |
EP2692328A1 (en) | 2012-08-03 | 2014-02-05 | Becton Dickinson France | Dose counting device for coupling with a medical container |
WO2014028745A2 (en) | 2012-08-17 | 2014-02-20 | Archon Pharmaceutical Consulting Llc | A system for compounding and packaging ready to reconstitute drug powders of solutions to a solution or to a suspension or to an injectable |
IL221635A0 (en) | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Drug vial mixing and transfer device for use with iv bag and drug vial |
IL221634A0 (en) | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Universal drug vial adapter |
JP5868555B2 (en) | 2012-09-13 | 2016-02-24 | メディモップ・メディカル・プロジェクツ・リミテッド | Nested female vial adapter |
JP6222512B2 (en) * | 2012-10-16 | 2017-11-01 | 株式会社ジェイ・エム・エス | Puncture needle adapter |
AU2013342123B2 (en) | 2012-11-12 | 2018-08-02 | Icu Medical, Inc. | Medical connector |
EP2735300A1 (en) | 2012-11-26 | 2014-05-28 | Becton Dickinson France | Adaptor for multidose medical container |
USD734868S1 (en) | 2012-11-27 | 2015-07-21 | Medimop Medical Projects Ltd. | Drug vial adapter with downwardly depending stopper |
US9724269B2 (en) * | 2012-11-30 | 2017-08-08 | Becton Dickinson and Company Ltd. | Connector for fluid communication |
CN103845217A (en) * | 2012-12-07 | 2014-06-11 | 裘建 | Disposable safety protection needle head |
US9089475B2 (en) | 2013-01-23 | 2015-07-28 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
ES2739291T3 (en) | 2013-01-23 | 2020-01-30 | Icu Medical Inc | Pressure regulation vial adapters |
US20140257204A1 (en) * | 2013-03-05 | 2014-09-11 | Stuart Robert Lessin | Apparatus for reconstituting and dispensing drugs for topical application |
US20140276422A1 (en) * | 2013-03-14 | 2014-09-18 | Medrad, Inc. | Bulk fluid source injector systems |
US10022301B2 (en) | 2013-03-15 | 2018-07-17 | Becton Dickinson and Company Ltd. | Connection system for medical device components |
AU2014238008B2 (en) | 2013-03-15 | 2018-11-08 | Icu Medical, Inc. | Medical connector |
US9414990B2 (en) | 2013-03-15 | 2016-08-16 | Becton Dickinson and Company Ltd. | Seal system for cannula |
IL225734A0 (en) | 2013-04-14 | 2013-09-30 | Medimop Medical Projects Ltd | Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor |
KR102155813B1 (en) * | 2013-04-24 | 2020-09-14 | 바이오메리욱스, 인코포레이티드. | Adapter caps for sample collection containers and associated molds with core pins and related methods |
IL226281A (en) | 2013-05-09 | 2017-01-31 | Kriheli Marino | Needle valve and connectors for use in liquid transfer apparatuses |
DK2983745T3 (en) | 2013-05-10 | 2018-10-22 | West Pharma Services Il Ltd | Medical devices comprising ampoule adapter with interconnected module for dry drug |
US9433721B2 (en) * | 2013-06-25 | 2016-09-06 | Fresenius Medical Care Holdings, Inc. | Vial spiking assemblies and related methods |
JP6617101B2 (en) * | 2013-07-19 | 2019-12-04 | アイシーユー メディカル インコーポレイテッド | Pressure regulating fluid transfer system and method |
AU2014295975B2 (en) | 2013-08-02 | 2018-08-02 | J&J SOLUTIONS, INC. d.b.a CORVIDA MEDICAL | Compounding systems and methods for safe medicament transport |
JP1526207S (en) | 2013-08-05 | 2015-06-15 | ||
USD765837S1 (en) | 2013-08-07 | 2016-09-06 | Medimop Medical Projects Ltd. | Liquid transfer device with integral vial adapter |
CN205626622U (en) * | 2013-08-07 | 2016-10-12 | 麦迪麦珀医疗工程有限公司 | Liquid transfer device that is used together with infusion container |
USD767124S1 (en) | 2013-08-07 | 2016-09-20 | Medimop Medical Projects Ltd. | Liquid transfer device with integral vial adapter |
EP2851057A1 (en) * | 2013-09-23 | 2015-03-25 | Becton Dickinson France | Assembly for coupling an adaptor with a medical container |
ES2722410T3 (en) * | 2013-11-06 | 2019-08-09 | Becton Dickinson & Co Ltd | Adapter for vial access device |
CN105848707B (en) | 2013-11-06 | 2020-06-16 | 贝克顿·迪金森有限公司 | Medical connector with locking engagement |
US10286201B2 (en) | 2013-11-06 | 2019-05-14 | Becton Dickinson and Company Limited | Connection apparatus for a medical device |
US9636278B2 (en) | 2013-11-06 | 2017-05-02 | Becton Dickinson and Company Limited | System for closed transfer of fluids with a locking member |
CN105792793B (en) | 2013-11-06 | 2020-08-14 | 贝克顿·迪金森有限公司 | Liquid-tight transfer system with connector |
WO2015077184A1 (en) | 2013-11-25 | 2015-05-28 | Icu Medical, Inc. | Methods and system for filling iv bags with therapeutic fluid |
WO2015088862A1 (en) | 2013-12-11 | 2015-06-18 | Icu Medical, Inc. | Check valve |
CA2937744C (en) | 2014-02-04 | 2022-08-09 | Icu Medical, Inc. | Self-priming systems and methods |
EP4218559A1 (en) | 2014-02-25 | 2023-08-02 | ICU Medical, Inc. | Patient monitoring system with gatekeeper signal |
USD794183S1 (en) | 2014-03-19 | 2017-08-08 | Medimop Medical Projects Ltd. | Dual ended liquid transfer spike |
DE102014104281B3 (en) | 2014-03-27 | 2015-09-10 | Medac Gesellschaft für klinische Spezialpräparate mbH | transfer device |
WO2015161047A1 (en) | 2014-04-16 | 2015-10-22 | Becton Dickinson and Company Limited | Fluid transfer device with axially and rotationally movable portion |
AU2015249915B2 (en) | 2014-04-21 | 2017-11-30 | Becton Dickinson and Company Limited | System for closed transfer of fluids |
US9833605B2 (en) | 2014-04-21 | 2017-12-05 | Becton Dickinson and Company Limited | Fluid transfer device and packaging therefor |
CN110353993B (en) | 2014-04-21 | 2022-04-12 | 贝克顿迪金森有限公司 | Bottle stabilizer base with attachable bottle adapter |
ES2948711T3 (en) | 2014-04-21 | 2023-09-18 | Becton Dickinson & Co Ltd | Syringe adapter with combined decoupling motion |
CN110368302B (en) | 2014-04-21 | 2023-03-10 | 贝克顿迪金森有限公司 | Diaphragm device for use with closed system transfer device |
JP6449910B2 (en) | 2014-04-21 | 2019-01-09 | ベクトン ディキンソン アンド カンパニー リミテッド | Fluid transfer device and packaging thereof |
EP3134052B1 (en) | 2014-04-21 | 2022-08-03 | Becton Dickinson and Company Limited | Syringe adapter with disconnection feedback mechanism |
CN109771280B (en) | 2014-04-21 | 2021-12-14 | 贝克顿迪金森有限公司 | System with adapter for the closed transfer of fluids |
AU2015277135B2 (en) | 2014-06-20 | 2020-02-20 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
USD757933S1 (en) | 2014-09-11 | 2016-05-31 | Medimop Medical Projects Ltd. | Dual vial adapter assemblage |
USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
US10736818B2 (en) * | 2014-12-17 | 2020-08-11 | Duoject Medical Systems Inc. | Reconstitution device with tip cap |
DE102015107312A1 (en) | 2014-12-30 | 2016-06-30 | Sfm Medical Devices Gmbh | Mixing and / or transfer device |
JP6358724B2 (en) | 2015-01-05 | 2018-07-18 | ウエスト・ファーマ.サービシーズ・イスラエル,リミテッド | Dual vial adapter assembly with easy removable pill adapter to ensure accurate use |
ES2921876T3 (en) * | 2015-01-09 | 2022-09-01 | Becton Dickinson & Co Ltd | infusion adapter |
US10420925B2 (en) | 2015-01-20 | 2019-09-24 | Oridion Medical 1987 Ltd. | Adapter |
WO2016153003A1 (en) * | 2015-03-26 | 2016-09-29 | テルモ株式会社 | Medical resin-made hollow needle, outer cylinder provided with puncture part, and pre-filled syringe |
JP2016187446A (en) * | 2015-03-30 | 2016-11-04 | テルモ株式会社 | Bottle needle for infusion container |
KR101620090B1 (en) * | 2015-04-20 | 2016-05-12 | 주식회사 티젤바이오 | Kit for drug delivery, Apparatus for preparing drug delivery system, and A preparation method of drug delivery system |
WO2016199116A1 (en) * | 2015-06-08 | 2016-12-15 | Teva Medical Ltd | Method for maintenance of sterility and integrity of a drug in liquid form |
CN113143759B (en) | 2015-07-16 | 2024-01-30 | 西部制药服务以色列有限公司 | Liquid drug transfer device for secure telescopic snap-fit on an injection vial |
WO2017049107A1 (en) | 2015-09-17 | 2017-03-23 | J&J SOLUTIONS, INC. d/b/a Corvida Medical | Medicament vial assembly |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
JP7017512B2 (en) | 2015-10-09 | 2022-02-08 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Bending fluid path type accessories for filled fluid containers |
EP3362114B1 (en) | 2015-10-13 | 2024-03-27 | Cormed Ltd | Automated compounding equipment for closed fluid transfer system |
CA3105936C (en) | 2015-10-19 | 2023-08-01 | Icu Medical, Inc. | Hemodynamic monitoring system with detachable display unit |
USD801522S1 (en) | 2015-11-09 | 2017-10-31 | Medimop Medical Projects Ltd. | Fluid transfer assembly |
US11458071B2 (en) * | 2017-05-11 | 2022-10-04 | Scalpal Llc | Torque enhancer device for grasping and tooling, and assemblies and uses thereof |
US10940086B2 (en) * | 2015-11-12 | 2021-03-09 | Scalpal Llc | Bottle support and protective collar |
BR112018010435B1 (en) | 2015-11-25 | 2022-06-28 | West Pharma. Services IL, Ltd. | DOUBLE AMPOULE ADAPTER SET FOR USE WITH A SYRINGE WITHOUT NEEDLE WITH A MALE CONNECTOR, A DRUG AMPOULE AND A LIQUID AMPOULE |
AU2016365335B2 (en) | 2015-12-04 | 2021-10-21 | Icu Medical, Inc. | Systems methods and components for transferring medical fluids |
IL243108B (en) * | 2015-12-22 | 2018-08-30 | Kriheli Marino | Connector section |
WO2017118110A1 (en) * | 2016-01-05 | 2017-07-13 | 胡绍勤 | Infusion tube |
CN105616159A (en) * | 2016-01-06 | 2016-06-01 | 杨炬 | Totally-enclosed multifunctional medicine dispensing and getting device |
JP6542481B2 (en) | 2016-01-21 | 2019-07-10 | ウェスト ファーマ サービシーズ イスラエル リミテッド | system |
EP3711793B1 (en) | 2016-01-21 | 2021-12-01 | West Pharma Services IL, Ltd. | A method of connecting a cartridge to an automatic injector |
CN113041432B (en) | 2016-01-21 | 2023-04-07 | 西医药服务以色列有限公司 | Medicament delivery device comprising a visual indicator |
US10022531B2 (en) | 2016-01-21 | 2018-07-17 | Teva Medical Ltd. | Luer lock adaptor |
CA3012733C (en) | 2016-01-29 | 2023-09-12 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
JP6741209B2 (en) * | 2016-03-02 | 2020-08-19 | 株式会社ジェイ・エム・エス | Filter assembly |
US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
IL245800A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | Dual vial adapter assemblages including identical twin vial adapters |
IL245803A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter |
WO2017207758A2 (en) * | 2016-06-03 | 2017-12-07 | Teva Medical Ltd. | A shielding device useful for manipulating a radioactive solution |
IL246073A0 (en) | 2016-06-06 | 2016-08-31 | West Pharma Services Il Ltd | Fluid transfer devices for use with drug pump cartridge having slidable driving plunger |
GB201610368D0 (en) * | 2016-06-15 | 2016-07-27 | Tech Partnership The Plc | Integrated cap and seal system |
USD851745S1 (en) | 2016-07-19 | 2019-06-18 | Icu Medical, Inc. | Medical fluid transfer system |
EP3487468A4 (en) | 2016-07-25 | 2020-03-25 | ICU Medical, Inc. | Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems |
JP6869327B2 (en) | 2016-08-01 | 2021-05-12 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Anti-rotation cartridge |
US10850873B2 (en) * | 2016-08-04 | 2020-12-01 | Vanrx Pharmasystems Inc. | Apparatus and method for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage |
IL247376A0 (en) | 2016-08-21 | 2016-12-29 | Medimop Medical Projects Ltd | Syringe assembly |
CA3033377C (en) * | 2016-08-22 | 2021-01-12 | Eli Lilly And Company | Secured medication transfer system |
AU2017335746A1 (en) | 2016-09-30 | 2019-04-11 | Icu Medical, Inc. | Pressure-regulating vial access devices and methods |
USD832430S1 (en) | 2016-11-15 | 2018-10-30 | West Pharma. Services IL, Ltd. | Dual vial adapter assemblage |
IL249408A0 (en) | 2016-12-06 | 2017-03-30 | Medimop Medical Projects Ltd | Liquid transfer device for use with infusion liquid container and pincers-like hand tool for use therewith for releasing intact drug vial therefrom |
BR112019014698A2 (en) | 2017-01-17 | 2020-02-18 | Becton Dickinson and Company Limited | CONNECTOR FOR CLOSED FLUID TRANSFER SYSTEM |
US11147740B2 (en) | 2017-01-17 | 2021-10-19 | Becton Dickinson and Company Limited | Syringe adapter with cap |
IL251458A0 (en) | 2017-03-29 | 2017-06-29 | Medimop Medical Projects Ltd | User actuated liquid drug transfer devices for use in ready-to-use (rtu) liquid drug transfer assemblages |
EP3607993A4 (en) | 2017-04-04 | 2021-01-06 | Nipro Corporation | Connector |
CN110869072B (en) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | Modular drive mechanism for a wearable injector |
DE102017005791B4 (en) * | 2017-06-21 | 2023-08-10 | Jan Willem Marinus Mijers | Transfer device for fluid transfer |
CA3070397A1 (en) | 2017-07-17 | 2019-01-24 | Baxter International Inc. | Dual container system for product reconstitution |
CA3072311A1 (en) | 2017-08-10 | 2019-02-14 | Simplivia Healthcare Ltd. | Syringe adaptor and complementary fluid-port adaptor |
AU2018320696A1 (en) * | 2017-08-23 | 2020-03-26 | Fresenius Kabi Deutschland Gmbh | Valve unit for a system for producing a medical preparation |
DE102017119345A1 (en) * | 2017-08-24 | 2019-02-28 | Gerresheimer Regensburg Gmbh | Adapter element for attaching a needle tip to a syringe body |
IL254802A0 (en) | 2017-09-29 | 2017-12-31 | Medimop Medical Projects Ltd | Dual vial adapter assemblages with twin vented female vial adapters |
EP3706704A4 (en) | 2017-11-10 | 2021-09-01 | Simplivia Healthcare Ltd. | Vial adaptor with housing |
US11752069B2 (en) | 2017-11-27 | 2023-09-12 | Healios K. K. | Method for transferring cellular medicine using a cellular medicine transfer system |
CN111867545B (en) | 2017-12-03 | 2021-11-23 | 西部制药服务有限公司(以色列) | Liquid transfer device with telescoping bottle adapter for use with infusion containers and discrete injection bottles |
IT201800002883A1 (en) * | 2018-02-20 | 2019-08-20 | Pierc Di Giovanelli Gabriele E C S A S | CONNECTOR FOR MEDICAL, DIAGNOSITIC AND PHYSOLOGICAL FLUID CONTAINERS |
USD907193S1 (en) | 2018-02-21 | 2021-01-05 | Eli Lilly And Company | Secured medication transfer set |
CA3174726A1 (en) | 2018-03-20 | 2019-09-26 | Becton Dickinson and Company Limited | Connection arrangement for closed system transfer of fluids |
USD903864S1 (en) | 2018-06-20 | 2020-12-01 | West Pharma. Services IL, Ltd. | Medication mixing apparatus |
JP1630477S (en) | 2018-07-06 | 2019-05-07 | ||
JP7441232B2 (en) | 2018-10-01 | 2024-02-29 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | Enteral feeding adapter and how to use the enteral feeding adapter |
USD923812S1 (en) | 2019-01-16 | 2021-06-29 | West Pharma. Services IL, Ltd. | Medication mixing apparatus |
EP3911377A1 (en) * | 2019-01-16 | 2021-11-24 | Boston Scientific Scimed Inc. | Cryotherapeutic delivery device |
USD896648S1 (en) * | 2019-01-16 | 2020-09-22 | Merck Sharp & Dohme, Corp. | Tamper-proof cap |
JP1648075S (en) | 2019-01-17 | 2019-12-16 | ||
PT3917486T (en) | 2019-01-31 | 2023-05-08 | West Pharma Services Il Ltd | Liquid transfer device |
JOP20200028A1 (en) * | 2019-02-26 | 2020-08-26 | Adienne Pharma & Biotech Sa | Sterile or sterilized package for administration of medicinal or nutritional substances |
KR102157612B1 (en) * | 2019-03-05 | 2020-09-18 | 김용현 | Syringe, drug mixing device, drug mixing kit comprising the same and method for manufacturing the same |
EP3718528A1 (en) | 2019-04-01 | 2020-10-07 | Simplivia Healthcare Ltd. | Vial adaptor with air resistor |
EP4360670A2 (en) * | 2019-04-30 | 2024-05-01 | West Pharma Services IL, Ltd | Liquid transfer device with dual lumen iv spike |
WO2020227701A1 (en) * | 2019-05-09 | 2020-11-12 | Vascular Integrity | Improved all-in one syringe assembly for blood draws and medicine delivery to patients |
USD931441S1 (en) | 2019-05-20 | 2021-09-21 | Icu Medical, Inc. | Port retention clip |
USD957630S1 (en) | 2019-05-20 | 2022-07-12 | Icu Medical, Inc. | Port retention clip |
USD930824S1 (en) | 2019-05-20 | 2021-09-14 | Icu Medical, Inc. | Port retention clip |
US11311458B2 (en) | 2019-09-11 | 2022-04-26 | B Braun Medical Inc. | Binary connector for drug reconstitution |
US10945922B1 (en) | 2019-09-26 | 2021-03-16 | Abyssal Systems, Inc. | Apparatus for creating a sealed conduit between separate volumes |
US11865076B2 (en) * | 2019-11-22 | 2024-01-09 | Aktivax, Inc. | Closed system for transferring medication from a flexible container |
US11806460B2 (en) * | 2019-12-06 | 2023-11-07 | Fresenius Medical Care Holdings, Inc. | Syringe warmer |
US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
USD956958S1 (en) | 2020-07-13 | 2022-07-05 | West Pharma. Services IL, Ltd. | Liquid transfer device |
US11674614B2 (en) | 2020-10-09 | 2023-06-13 | Icu Medical, Inc. | Fluid transfer device and method of use for same |
FR3117774B1 (en) * | 2020-12-23 | 2023-03-31 | A Raymond Et Cie | ADAPTIVE CAP PIERCING CLIP FOR MEDICAL VIAL |
DE102021108157A1 (en) | 2021-03-31 | 2022-10-06 | B. Braun Melsungen Aktiengesellschaft | Fluid transfer device and closed drug delivery system |
USD1010112S1 (en) | 2021-07-03 | 2024-01-02 | KAIRISH INNOTECH Private Ltd. | Vial adapter with valve |
WO2023170680A1 (en) * | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853158A (en) * | 1973-02-05 | 1974-12-10 | Sinai Hospital Of Detroit | Apparatus for inserting a syringe needle into a vial |
US4576211A (en) * | 1984-02-24 | 1986-03-18 | Farmitalia Carlo Erba S.P.A. | Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe |
US4619651A (en) * | 1984-04-16 | 1986-10-28 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
US5810792A (en) * | 1996-04-03 | 1998-09-22 | Icu Medical, Inc. | Locking blunt cannula |
US6120490A (en) * | 1995-07-11 | 2000-09-19 | Debiotech S.A. | Piercing pin for an infusion system |
US6146362A (en) * | 1993-08-27 | 2000-11-14 | Baton Development, Inc. | Needleless IV medical delivery system |
US6394979B1 (en) * | 2000-06-09 | 2002-05-28 | Inviro Medical Devices Ltd. | Cannula for use with a medical syringe |
US6478788B1 (en) * | 1999-02-10 | 2002-11-12 | Biodome | Device for connection between a recipient and a container and ready-to-use assembly comprising such a device |
US6544246B1 (en) * | 2000-01-24 | 2003-04-08 | Bracco Diagnostics, Inc. | Vial access adapter and vial combination |
US6551299B2 (en) * | 2000-04-10 | 2003-04-22 | Nipro Corp. | Adapter for mixing and injection of preparations |
US6715520B2 (en) * | 2001-10-11 | 2004-04-06 | Carmel Pharma Ab | Method and assembly for fluid transfer |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2627857A (en) * | 1949-07-21 | 1953-02-10 | Marcelli Attilio | Syringe holder |
US2842276A (en) * | 1955-08-02 | 1958-07-08 | Cutter Lab | Container closure |
US3359977A (en) * | 1965-03-19 | 1967-12-26 | Burron Medical Prod Inc | Air filter means |
GB1257419A (en) | 1970-04-07 | 1971-12-15 | ||
JPS4832585B1 (en) | 1970-08-11 | 1973-10-06 | ||
US3872867A (en) * | 1971-06-02 | 1975-03-25 | Upjohn Co | Wet-dry additive assembly |
US4128098A (en) * | 1976-12-06 | 1978-12-05 | American Hospital Supply Corporation | Valved spike transfer device |
US4338980A (en) * | 1980-01-14 | 1982-07-13 | Schwebel Paul R | Device for filling medicament injectors |
JPS59141954A (en) * | 1983-01-24 | 1984-08-14 | ジヨージ・エイ・ロペツ | Medical connector system |
SE434700B (en) * | 1983-05-20 | 1984-08-13 | Bengt Gustavsson | DEVICE FOR AIRED TRANSFER OF SUBSTANCE FROM A KERLE TO ANOTHER |
EP0123659A1 (en) * | 1983-03-21 | 1984-10-31 | Jan Ingemar Näslund | An arrangement in apparatus for preparing solutions from harmful substances |
EP0126718A3 (en) * | 1983-05-20 | 1985-10-23 | Bengt Gustavsson | A device for transferring a substance from one vessel to another and further to the intended application |
US4743243A (en) * | 1984-01-03 | 1988-05-10 | Vaillancourt Vincent L | Needle with vent filter assembly |
US4588403A (en) | 1984-06-01 | 1986-05-13 | American Hospital Supply Corporation | Vented syringe adapter assembly |
US4759756A (en) * | 1984-09-14 | 1988-07-26 | Baxter Travenol Laboratories, Inc. | Reconstitution device |
US4834152A (en) * | 1986-02-27 | 1989-05-30 | Intelligent Medicine, Inc. | Storage receptacle sealing and transfer apparatus |
US4775376A (en) | 1986-07-09 | 1988-10-04 | Erbamont, Inc. | Method and apparatus for catching fluids purged from a syringe |
JP2519220B2 (en) * | 1986-09-27 | 1996-07-31 | 株式会社東芝 | Telephone controller |
ES1002629Y (en) | 1987-06-05 | 1989-01-16 | Badia Marcelo Segura | CONNECTION FOR CATHETERS, PERFUSION EQUIPMENT AND LIQUID BOTTLES TO BE PERFUSED |
US4768568A (en) | 1987-07-07 | 1988-09-06 | Survival Technology, Inc. | Hazardous material vial apparatus providing expansible sealed and filter vented chambers |
US5100394A (en) | 1988-01-25 | 1992-03-31 | Baxter International Inc. | Pre-slit injection site |
CA2001732A1 (en) * | 1988-10-31 | 1990-04-30 | Lawrence A. Lynn | Intravenous line coupling device |
US5167816A (en) * | 1990-08-20 | 1992-12-01 | Abbott Laboratories | Sterile coupling device for drug container |
US5100010A (en) * | 1990-11-08 | 1992-03-31 | The West Company, Incorporated | Containment seal assembly |
US5354287A (en) * | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
ES2027923A6 (en) | 1991-01-30 | 1992-06-16 | Segura Badia Marcelo | Disinfecting connection for catheters and the like. |
DE4104649A1 (en) | 1991-02-15 | 1992-09-03 | Deutsche Forsch Luft Raumfahrt | DEVICE FOR INJECTING A FLUID IN A RECEIVER |
US5184652A (en) * | 1991-07-02 | 1993-02-09 | Fan Chin Fu | Universal medication port |
WO1993002921A1 (en) * | 1991-08-07 | 1993-02-18 | Habley Medical Technology Corporation | Metered syringe filling device for pharmaceutical containers |
US5329976A (en) * | 1991-12-09 | 1994-07-19 | Habley Medical Technology Corporation | Syringe-filling and medication mixing dispenser |
CN2126081U (en) | 1992-05-09 | 1992-12-30 | 佟生 | Disposable multfunctional blood transfusion set and infusion device |
US5364386A (en) * | 1993-05-05 | 1994-11-15 | Hikari Seiyaku Kabushiki Kaisha | Infusion unit |
JP3325896B2 (en) | 1993-09-07 | 2002-09-17 | デビオテック ソシエテ アノニム | Syringe device for mixing two components |
JP3475414B2 (en) * | 1994-01-28 | 2003-12-08 | ニプロ株式会社 | Adapter for co-infusion |
WO1995024176A1 (en) * | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
AU2945495A (en) * | 1994-06-24 | 1996-01-19 | Icu Medical, Inc. | Fluid transfer device and method of use |
US5549566A (en) | 1994-10-27 | 1996-08-27 | Abbott Laboratories | Valved intravenous fluid line infusion device |
US5501676A (en) * | 1995-01-13 | 1996-03-26 | Sanofi Winthrop, Inc. | Coupling system for safety cannula |
US5647845A (en) | 1995-02-01 | 1997-07-15 | Habley Medical Technology Corporation | Generic intravenous infusion system |
US5647409A (en) * | 1995-04-04 | 1997-07-15 | Allergan | On-site syringe filling apparatus for viscoelastic materials, and corresponding method for on-site syringe filling |
SE509950C2 (en) | 1995-05-02 | 1999-03-29 | Carmel Pharma Ab | Device for the administration of toxic liquid |
US5738663A (en) * | 1995-12-15 | 1998-04-14 | Icu Medical, Inc. | Medical valve with fluid escape space |
US5807347A (en) | 1995-12-21 | 1998-09-15 | Bonaldo; Jean M. | Medical valve element |
ES2176661T3 (en) | 1996-01-11 | 2002-12-01 | Duoject Inc | SUPPLY SYSTEM FOR PHARMACEUTICAL PRODUCTS PACKAGED IN VIALESPHARMACEUTICALS. |
US5860456A (en) | 1996-03-22 | 1999-01-19 | Eli Lilly And Company | Syringe alignment device |
GB9609563D0 (en) * | 1996-05-08 | 1996-07-10 | Sterimatic Holdings Ltd | Venting devices |
DE19622034C1 (en) | 1996-05-31 | 1997-08-14 | Ver Dentalwerke Antaeos | Distribution device for marking discs for limiting penetration depth of tooth root channel preparation instruments |
GB9611562D0 (en) | 1996-06-03 | 1996-08-07 | Applied Research Systems | Device |
US6273869B1 (en) | 1996-06-13 | 2001-08-14 | Vincent L. Vaillancourt | Valve connector |
FR2753624B1 (en) | 1996-09-25 | 1999-04-16 | Biodome | CONNECTION DEVICE, PARTICULARLY BETWEEN A CONTAINER WITH PERFORABLE CAP AND A SYRINGE |
GB9701413D0 (en) * | 1997-01-24 | 1997-03-12 | Smithkline Beecham Biolog | Novel device |
IT236233Y1 (en) * | 1997-11-26 | 2000-08-08 | Eurospital S P A | DEVICE FOR THE CONNECTION OF A PHARMACEUTICAL PRODUCT CONTAINER TO A BAG OF LIQUID PRODUCT TO CARRY OUT THE |
US6159192A (en) * | 1997-12-04 | 2000-12-12 | Fowles; Thomas A. | Sliding reconstitution device with seal |
US6003566A (en) | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
US6209738B1 (en) * | 1998-04-20 | 2001-04-03 | Becton, Dickinson And Company | Transfer set for vials and medical containers |
US6378714B1 (en) | 1998-04-20 | 2002-04-30 | Becton Dickinson And Company | Transferset for vials and other medical containers |
US6113583A (en) * | 1998-09-15 | 2000-09-05 | Baxter International Inc. | Vial connecting device for a sliding reconstitution device for a diluent container |
US7074216B2 (en) * | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
AR021220A1 (en) * | 1998-09-15 | 2002-07-03 | Baxter Int | CONNECTION DEVICE FOR ESTABLISHING A FLUID COMMUNICATION BETWEEN A FIRST CONTAINER AND A SECOND CONTAINER. |
SE513225C2 (en) | 1998-12-03 | 2000-08-07 | Carmel Pharma Ab | Arrangement, procedure and gas container for sterile or aseptic handling |
US6776776B2 (en) * | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
US6453956B2 (en) * | 1999-11-05 | 2002-09-24 | Medtronic Minimed, Inc. | Needle safe transfer guard |
AUPQ455999A0 (en) | 1999-12-09 | 2000-01-06 | Silverbrook Research Pty Ltd | Memjet four color modular print head packaging |
WO2001060436A1 (en) | 2000-02-15 | 2001-08-23 | Comar, Inc. | Needleless access apparatus and system |
WO2001070146A2 (en) * | 2000-02-28 | 2001-09-27 | Coripharm Medizinprodukte Gmbh & Co. Kg | Preparation and application device for implant materials |
DE10034270A1 (en) * | 2000-07-14 | 2002-02-14 | Disetronic Licensing Ag | Storage container with a metering device for the metered delivery of an injectable product to an injection device |
SE517084C2 (en) | 2000-08-10 | 2002-04-09 | Carmel Pharma Ab | Procedures and devices for aseptic preparation |
JP4472137B2 (en) * | 2000-09-07 | 2010-06-02 | 株式会社アルテ | Container / Syringe |
FR2815328B1 (en) | 2000-10-17 | 2002-12-20 | Biodome | CONNECTION DEVICE BETWEEN A CONTAINER AND A CONTAINER AND READY-TO-USE ASSEMBLY COMPRISING SUCH A DEVICE |
AU2002237703A1 (en) * | 2000-11-09 | 2002-06-18 | Biovalve Technologies, Inc. | Microneedle adapter |
CN2452515Y (en) | 2000-12-21 | 2001-10-10 | 黄红军 | Disposable syringe with contamination proof type medicine adding means |
US20020087118A1 (en) * | 2000-12-29 | 2002-07-04 | Duoject Medical Systems Inc. | Pharmaceutical delivery system |
JP3820889B2 (en) | 2001-02-05 | 2006-09-13 | ニプロ株式会社 | Infusion container |
EP1372756A4 (en) * | 2001-03-13 | 2008-05-21 | Mdc Invest Holdings Inc | Pre-filled safety vial injector |
US6641648B2 (en) * | 2001-04-17 | 2003-11-04 | Foster-Miller, Inc. | Passive filtration system |
FR2829691B1 (en) * | 2001-09-17 | 2004-07-09 | Sedat | DEVICE FOR BIDIRECTIONAL TRANSFER OF A LIQUID BETWEEN A BOTTLE AND A CARPULE |
JP2005531334A (en) * | 2001-10-15 | 2005-10-20 | マリンクロッド・インコーポレイテッド | Radiopharmaceutical capsule dispensing system |
ES2262733T3 (en) | 2001-12-17 | 2006-12-01 | Bristol-Myers Squibb Company | TRANSFER DEVICE AND SYSTEM THAT INCLUDES A COVER ASSEMBLY, A CONTAINER AND THE TRANSFER DEVICE. |
EP1321403A1 (en) | 2001-12-20 | 2003-06-25 | Mars Incorporated | Method and apparatus for aligning a banknote |
US6875205B2 (en) * | 2002-02-08 | 2005-04-05 | Alaris Medical Systems, Inc. | Vial adapter having a needle-free valve for use with vial closures of different sizes |
US7744581B2 (en) | 2002-04-08 | 2010-06-29 | Carmel Pharma Ab | Device and method for mixing medical fluids |
US7867215B2 (en) * | 2002-04-17 | 2011-01-11 | Carmel Pharma Ab | Method and device for fluid transfer in an infusion system |
CA2480972C (en) * | 2002-04-24 | 2010-12-07 | Ares Trading Sa | Device for preparing a medicinal liquid and method for preserving a solution of medicament for injection |
ATE389427T1 (en) | 2002-07-09 | 2008-04-15 | Carmel Pharma Ab | COUPLING MEANS FOR TRANSFER OF MEDICAL SUBSTANCES |
US8377039B2 (en) * | 2002-10-04 | 2013-02-19 | Nxstage Medical, Inc. | Injection site for male luer or other tubular connector |
US7086431B2 (en) * | 2002-12-09 | 2006-08-08 | D'antonio Consultants International, Inc. | Injection cartridge filling apparatus |
US6948522B2 (en) * | 2003-06-06 | 2005-09-27 | Baxter International Inc. | Reconstitution device and method of use |
CN1886295B (en) | 2003-10-30 | 2010-05-26 | 泰瓦医学有限公司 | Drug mixing system and drug mixing method |
US8210166B2 (en) | 2003-12-16 | 2012-07-03 | Wolfe Tory Medical, Inc. | Vial multi-access adapter |
ITTO20050516A1 (en) | 2005-07-25 | 2007-01-26 | Borla Ind | MEDICAL CONNECTOR |
WO2007038643A1 (en) * | 2005-09-26 | 2007-04-05 | C.R. Bard, Inc. | Catheter connection systems |
PL1951344T3 (en) | 2005-11-07 | 2015-02-27 | Borla Ind | Vented safe handling vial adapter |
DE102006020286A1 (en) | 2006-04-27 | 2007-10-31 | Johannes-Gutenberg-Universität Mainz | Syringe extracting microliter quantities of fluid from container, has canula with side opening sealed in cover, when extracted from container |
US7857805B2 (en) | 2006-10-02 | 2010-12-28 | B. Braun Medical Inc. | Ratcheting luer lock connector |
EP1917996B1 (en) | 2006-10-31 | 2009-02-18 | Codan Holding GmbH | Luer Lock connector which is not disconnectable |
BRPI0810542A2 (en) | 2007-04-23 | 2014-10-21 | Plastmed Ltd | METHOD FOR TRANSFER WITHOUT LIQUID CONTAMINATION, FLUID TRANSFER APPARATUS, EQUIPMENT COUPLING METHOD, CONNECTOR SECTION FOR USE IN A FLUID TRANSFER OPERATION AND CONNECTION SECTION COUPLING METHOD |
WO2008144575A2 (en) | 2007-05-18 | 2008-11-27 | Optiscan Biomedical Corporation | Fluid injection and safety system |
WO2009038860A2 (en) * | 2007-09-18 | 2009-03-26 | Medeq Llc | Medicament mixing and injection apparatus |
US8123736B2 (en) | 2009-02-10 | 2012-02-28 | Kraushaar Timothy Y | Cap adapters for medicament vial and associated methods |
AU2011258371B2 (en) | 2010-05-27 | 2014-09-18 | J&J Solutions, Inc. | Closed fluid transfer system |
EP2589409A1 (en) | 2010-06-30 | 2013-05-08 | Terumo Kabushiki Kaisha | Connector and connector assembly |
IL212420A0 (en) * | 2011-04-17 | 2011-06-30 | Medimop Medical Projects Ltd | Liquid drug transfer assembly |
JP2014528337A (en) * | 2011-10-14 | 2014-10-27 | ノボ ノルディスク ヘルス ケア アーゲー | Pre-assembled fluid transfer device |
US10022531B2 (en) * | 2016-01-21 | 2018-07-17 | Teva Medical Ltd. | Luer lock adaptor |
-
2004
- 2004-10-29 CN CN2004800353898A patent/CN1886295B/en active Active
- 2004-10-29 EP EP20120154647 patent/EP2463201B1/en active Active
- 2004-10-29 EP EP04791853A patent/EP1687203A4/en not_active Withdrawn
- 2004-10-29 EP EP13179757.3A patent/EP2664550B8/en active Active
- 2004-10-29 DK DK13179757T patent/DK2664550T3/en active
- 2004-10-29 PL PL12154647T patent/PL2463201T3/en unknown
- 2004-10-29 DK DK12154647T patent/DK2463201T3/en active
- 2004-10-29 HU HUE13179757A patent/HUE046864T2/en unknown
- 2004-10-29 CA CA2792014A patent/CA2792014C/en active Active
- 2004-10-29 US US10/577,618 patent/US8122923B2/en active Active
- 2004-10-29 ES ES12154647T patent/ES2461190T3/en active Active
- 2004-10-29 PT PT121546477T patent/PT2463201E/en unknown
- 2004-10-29 JP JP2006537556A patent/JP4740146B2/en active Active
- 2004-10-29 SI SI200432482T patent/SI2664550T1/en unknown
- 2004-10-29 EP EP16173568.3A patent/EP3108911A1/en active Pending
- 2004-10-29 IN IN187MUN2014 patent/IN2014MN00187A/en unknown
- 2004-10-29 ES ES13179757T patent/ES2753239T3/en active Active
- 2004-10-29 WO PCT/IL2004/000993 patent/WO2005041846A2/en active Application Filing
- 2004-10-29 CA CA2541615A patent/CA2541615C/en active Active
- 2004-10-29 SI SI200432156T patent/SI2463201T1/en unknown
- 2004-10-29 RU RU2006119427A patent/RU2355377C2/en active
-
2006
- 2006-04-06 IL IL174838A patent/IL174838A/en active IP Right Grant
-
2007
- 2007-02-08 HK HK07101498.8A patent/HK1094563A1/en unknown
-
2010
- 2010-08-25 JP JP2010188726A patent/JP4832585B2/en active Active
- 2010-09-07 JP JP2010200146A patent/JP4927977B2/en active Active
-
2012
- 2012-01-24 US US13/357,004 patent/US8511352B2/en active Active
-
2013
- 2013-04-01 US US13/854,348 patent/US9345641B2/en active Active
- 2013-07-31 US US13/955,375 patent/US9532927B2/en active Active
-
2016
- 2016-05-02 US US15/143,845 patent/US9549875B2/en active Active
- 2016-06-07 US US15/175,385 patent/US20170021156A1/en not_active Abandoned
-
2017
- 2017-11-08 US US15/806,654 patent/US10953216B2/en active Active
-
2021
- 2021-02-22 US US17/181,452 patent/US11224730B2/en active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853158A (en) * | 1973-02-05 | 1974-12-10 | Sinai Hospital Of Detroit | Apparatus for inserting a syringe needle into a vial |
US4576211A (en) * | 1984-02-24 | 1986-03-18 | Farmitalia Carlo Erba S.P.A. | Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe |
US4619651A (en) * | 1984-04-16 | 1986-10-28 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
US6146362A (en) * | 1993-08-27 | 2000-11-14 | Baton Development, Inc. | Needleless IV medical delivery system |
US6120490A (en) * | 1995-07-11 | 2000-09-19 | Debiotech S.A. | Piercing pin for an infusion system |
US5810792A (en) * | 1996-04-03 | 1998-09-22 | Icu Medical, Inc. | Locking blunt cannula |
US6478788B1 (en) * | 1999-02-10 | 2002-11-12 | Biodome | Device for connection between a recipient and a container and ready-to-use assembly comprising such a device |
US6544246B1 (en) * | 2000-01-24 | 2003-04-08 | Bracco Diagnostics, Inc. | Vial access adapter and vial combination |
US6551299B2 (en) * | 2000-04-10 | 2003-04-22 | Nipro Corp. | Adapter for mixing and injection of preparations |
US6394979B1 (en) * | 2000-06-09 | 2002-05-28 | Inviro Medical Devices Ltd. | Cannula for use with a medical syringe |
US6715520B2 (en) * | 2001-10-11 | 2004-04-06 | Carmel Pharma Ab | Method and assembly for fluid transfer |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11224555B2 (en) | 2018-04-23 | 2022-01-18 | Hospira, Inc. | Access and vapor containment system for a drug vial and method of making and using same |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11224730B2 (en) | Safely drug handling device | |
CA2650966C (en) | Vented infusion access device | |
CA2476075C (en) | Device for mixing medical fluids, and method for enabling such mixing | |
EP2124866B1 (en) | A piercing member protection device | |
JP2007509691A5 (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: TEVA MEDICAL LTD., ISRAEL Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KRAUSS, MENACHEM;SHEMESH, ELI;SIGNING DATES FROM 20060628 TO 20060702;REEL/FRAME:038830/0089 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |