US20110004297A1 - Translumenal apparatus, system, and method - Google Patents
Translumenal apparatus, system, and method Download PDFInfo
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- US20110004297A1 US20110004297A1 US12/877,642 US87764210A US2011004297A1 US 20110004297 A1 US20110004297 A1 US 20110004297A1 US 87764210 A US87764210 A US 87764210A US 2011004297 A1 US2011004297 A1 US 2011004297A1
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- cord
- catheter
- heart valve
- delivery catheter
- heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0409—Instruments for applying suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0472—Multiple-needled, e.g. double-needled, instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
- A61F2/2457—Chordae tendineae prostheses
Abstract
Methods, apparatus, and systems for altering the configuration of a heart valve. Methods, apparatus, and systems include the use of a cord delivered into the heart by a delivery catheter that can be manipulated by a receiving catheter so as to improve the heart valve function.
Description
- This application is a continuation of U.S. patent application Ser. No. 11/337,162, filed Jan. 20, 2006, of which is herein incorporated by reference.
- The present invention relates generally to apparatus, systems, and methods for use in a heart, more particularly to apparatus, systems, and methods for improving the function of a heart valve.
- The human heart is divided into four chambers. These four chambers include the right atrium and the right ventricle, and the left atrium and the left ventricle. The heart contracts rhythmically under stimulation of electrical currents to move blood through the chambers of the heart and the remainder of the cardiovascular system.
- Blood in the heart is kept flowing in a unidirectional manner through the cardiovascular system by a system of four one-way valves. As the heart cycles the valves open and close to allow blood to move one-way through the heart chambers.
- The heart valves differ significantly in structure. For example, the ventricles are separated from the atria by valves that, in addition to the leaflets, have thin but strong cords of fibrous tissue. Called chordae tendineae, these cords tether the valve to the ventricular walls. When the ventricles contract, small muscles in their walls, called papillary muscles, pull the cords which act as tethers, and control the closure of the valve leaflets, preventing them from flapping too far backwards.
- One such valve located between the left ventricle and the left atrium is called the mitral valve. The mitral valve has two leaflets that form the valve. The leaflets are attached to papillary muscles by way of the chordae tendineae and it allows blood to enter the left ventricle from the left atrium.
- When operating properly, the mitral valve acts as a one-way valve. There are, however, numerous conditions that can cause the mitral valve to not act as a one-way valve. For example, deficiency or degeneration of one or more of the mitral valve structures may result in dysfunction of the mitral valve apparatus leading to mitral valve prolapse or regurgitation during a contraction of the heart. Prolapse or regurgitation of the mitral valve can eventually lead to severe cardiovascular problems, and even death.
-
FIG. 1 provides a schematic cross-section of a heart, segments of which have been removed to show detail. -
FIG. 2 provides a schematic cross-section of a heart, segments of which have been removed to show detail. -
FIG. 3 illustrates one embodiment of an apparatus according to the present invention. -
FIGS. 4A-4F illustrate one embodiment of an apparatus according to the present invention. -
FIGS. 5A-5F illustrate one embodiment of an apparatus according to the present invention located within the cardiovascular system. -
FIGS. 6A-6F illustrate one embodiment of an apparatus according to the present invention located within the cardiovascular system. - Embodiments of the present invention are directed to methods, apparatus, and systems for helping to improve heart valve function. As discussed herein, improving heart valve function can be accomplished by altering the configuration of the heart valve according to various embodiments of the invention. For example, altering the configuration of the heart valve can be accomplished through the use of a cord delivered into the heart by a delivery catheter. The cord can be positioned relative the heart valve in such a way that by manipulating aspects of the cord (e.g., its length) the configuration of the heart valve can be alter so as to improve the heart valve function. These and other embodiments of the present invention are discussed herein.
- The figures herein follow a numbering convention in which the first digit or digits correspond to the drawing figure number and the remaining digits identify an element or component in the drawing. Similar elements or components between different figures may be identified by the use of similar digits. For example, 110 may reference element “10” in
FIG. 1 , and a similar element may be referenced as 210 inFIG. 2 . As will be appreciated, elements shown in the various embodiments herein can be added, exchanged, and/or eliminated so as to provide a number of additional embodiments of the valve according to the present invention. -
FIG. 1 illustrates a schematic cross-section of aheart 100. Theheart 100 is divided into four chambers, which are referred to herein as afirst chamber 102, asecond chamber 104, athird chamber 106 and afourth chamber 108. With respect to the anatomy of the heart, thefirst chamber 102 can represent the left atrium, thesecond chamber 104 can represent the left ventricle, thethird chamber 106 can represent the right atrium, and thefourth chamber 108 can represent the right ventricle. Other representations for thechambers -
Heart 100 further includes heart valves positioned at either an inlet or an outlet of the four chambers of theheart 100. These heart valves include amitral valve 114, anaortic valve 116,pulmonary valve 118, andtricuspid valve 120. Generally, each heart valve includes valve leaflets. For example, the structure of themitral valve 114, the one-way heart valve that divides the first chamber 102 (i.e., the left atrium) and the second chamber 104 (i.e., the left ventricle), includes two leaflets. These two leaflets are referred to as the anterior leaflet 122-1 and the posterior leaflet 122-2. The anterior and posterior leaflets 122-1 and 122-2 move between an open position in which antegrade blood flow moves from thefirst chamber 102 to thesecond chamber 104, to a closed position that prevents retrograde flow of the blood from thesecond chamber 104 to thefirst chamber 102. - The anterior and posterior leaflets 122-1 and 122-2 are attached to a variety of structures that help to maintain the function of the
mitral valve 114. For example, themitral valve 114 includes a fibrous tissue ring structure, referred to as themitral annulus 124, which surrounds and supports the anterior and posterior leaflets 122-1 and 122-2. Themitral annulus 124 can be conceptually divided into an anterior mitral annulus 126-1 and a posterior mitral annulus 126-2. The anterior leaflet 122-1 and posterior leaflet 122-2 are supported by themitral annulus 124 by their connection to the anterior mitral annulus 126-1 and the posterior mitral annulus 126-2, respectively. - The
mitral valve 114 further includes fibrous tissue calledchordae tendineae 110. Thechordae tendineae 110 function to tether the leaflets 122-1 and 122-2 of themitral valve 114 to theventricular walls 115. In addition, themitral valve 114 also includespapillary muscles 112 that extend from theventricular walls 115 to couple to thechordae tendineae 110. When the ventricles contract, thepapillary muscles 112 pull thechordae tendineae 110 which act as tethers, and control the closure or coaptation of the valve leaflets 122-1 and 122-2, preventing them from flapping too far backwards (prolapse). - When operating properly, the
mitral valve 114 acts as a one-way valve. There are, however, numerous conditions that can cause themitral valve 114 to not act as a one-way valve. For example, deficiency or degeneration of one or more of themitral valve 114 structures may result in dysfunction of the mitral valve apparatus leading to mitral valve prolapse or regurgitation during a contraction of the heart. Mitral valve prolapse is a condition in which blood leaks in the wrong direction (regurgitation of the blood) because one or more of the valve leaflets 122-1 and/or 122-2 close improperly. Reasons for why the valve leaflets 122-1 and/or 122-2 close improperly can include, for example, changes in the size and shape of the valves leaflets 122-1 and/or 122-2 and/or the mitral annulus 124 (e.g., an increase in the circumference of the mitral annulus 124). -
FIG. 2 illustrates a cross-section of thefirst chamber 202 and thesecond chamber 204 of theheart 200. In the present example, the valve leaflets 222-1 and 222-2 in their native state do not close properly, leading to the condition of mitral valve prolapse for theheart 200. -
FIG. 2 also illustrates the presence of acord 230 within theheart 200 according to various embodiments of the invention. Thecord 230 can be delivered and positioned percutaneously within theheart 200, as discussed herein. Thecord 230 allows for the configuration of the native heart valve to be modified in such a way that there can be an improvement in the functioning of the heart valve. In other words, thecord 230 can be used to change the physical relationship of the different parts of the heart valve in such a way as to help restore a more normal operation of the heart valve (e.g., reduce regurgitation of the blood). - In the illustration provided in
FIG. 2 , the heart valve being modified by thecord 230 is themitral valve 214, as discussed herein. Other heart valves can be modified with thecord 230 so as to improve valve performance, where the number and relationship of one or more cords used to accomplish this goal depends upon the valve being modified. For example, a tri-leaflet heart valve, such as the aortic valve, might be modified using at least two cords having an approximately equilateral relationship (i.e., the at least two cords cross each other at a point to form an angle of approximately ninety (90) degrees). In an additional example, three cords could be used to modify the configuration of the valve, where the cords could have a predetermined relationship relative each other (i.e., the at least two cords cross each other at a point to form an angle of approximately sixty (60) degrees). - As will be discussed more fully herein, the
cord 230 can be delivered to the heart valve (e.g., the mitral valve 214) by a delivery catheter. In one example, the delivery catheter can be used to pass a first end and a second end of the cord between thefirst heart chamber 202 and thesecond heart chamber 204, or visa versa. The first and second ends of thecord 230 can then be used in forming a loop around the heart valve. The length of the loop formed with the cord can then be manipulated (e.g., shortened) so as to modify the configuration of the heart valve. - In one embodiment, the configuration of the heart valve can be modified so as to induce coaptation of the valve leaflets at the proper time in the cardiac cycle. For example, the closed circumference of the loop formed with the
cord 230 can have a constraining effect on the valve leaflets perpendicularly to the plane of their coaptation. The cord can also change the shape of themitral annulus 224 in such a way that the valve leaflets 222-1 and 222-2 are drawn more closely together to allow formajor surfaces 228 of the leaflets to seal when thevalve 214 is in its closed configuration. In its open configuration, constraining the valve leaflets with the closed circumference of the loop formed with thecord 230 can further modify the heart valve to create a modified orifice (e.g., a double orifice) for theheart valve 214, where there had been an unmodified orifice (e.g., a single orifice) prior to the use of thecord 230. - As will be appreciated, a variety of apparatus and/or systems can be utilized in delivering and manipulating the
cord 230. For example, delivery catheter based apparatus and/or systems can be utilized in delivering and manipulating thecord 230 according to a variety of the embodiments of the present invention. These apparatus and/or systems can both house thecord 230 and provide the structure through which thecord 230 can be delivered between thefirst heart chamber 202 and thesecond heart chamber 204. The following discussion provides various embodiments of the present invention. -
FIG. 3 provides a schematic illustration of anapparatus 332 according to one embodiment of the present invention. Theapparatus 332 includes adelivery catheter 334 for positioning and passing at least a portion of thecord 330 between chambers of the heart, as discussed herein. Thedelivery catheter 334 has anelongate body 336 with aproximal end 338 and adistal end 340. Thedelivery catheter 334 further includes at least onepredetermined bend 342 in theelongate body 336 between theproximal end 338 and thedistal end 340. As discussed herein, thepredetermined bend 342 allows thedistal end 340 of thecatheter 334 to be positioned adjacent the heart valve, such as the mitral valve, as will be discussed herein. - The
delivery catheter 334 of the present embodiment farther includes a first piercingmember 344 and a second piercingmember 346. The first and second piercingmembers delivery catheter 334 in such a way that they can extend and separate from thedelivery catheter 334. For example, as illustrated the first and second piercingmembers first lumen 348 and asecond lumen 350, respectively, where thelumens distal end 340 towards theproximal end 338 of thedelivery catheter 334. - The first and second piercing
members cord 330. For example, the first piercingmember 344 can be associated with afirst end 352 of thecord 330 and the second piercingmember 346 can be associated with asecond end 354 of thecord 330. In one embodiment, associating thecord 330 with the first and second piercingmembers - Alternatively, the first and second piercing
members cord 330 itself. For example, a portion of thecord 330 at or adjacent the first and second ends 352 and 354 of thecord 330 could be modified so as to form the first and second piercingmembers cord 330 at and/or adjacent the first and second ends 352 and 354 to form at least a shaft having a sharp point to act as a piercing member. -
FIG. 3 further illustrates that thecord 330 can be releasably positioned at least partially within the first andsecond lumen cord 330 can be released from the first andsecond lumen members delivery catheter 334. In one embodiment, thecord 330 could at least partially reside in a groove that extends into theelongate body 336 from the first andsecond lumen cord 330 adjacent the first and second piercingmembers lumens cord 330 and the first and second piercingmembers lumens members cord 330 are deployed. - The
delivery catheter 334 further includes afirst deployment rod 356 and asecond deployment rod 358. In one embodiment, thefirst deployment rod 356 extends from theproximal end 338 through thefirst lumen 348 to abut the first piercingmember 344. Similarly, thesecond deployment rod 358 extends from theproximal end 338 through thesecond lumen 350 to abut the second piercingmember 346. - Both the first and
second deployment rods second deployment rods delivery catheter 334 and into the cardiac tissue as discussed herein. As will be appreciated, the column strength of thedeployment rods lumen - The first and
second deployment rods cord 330 can be formed from a number of different materials in a number of different configurations. For example, therods cord 330 can be formed of, by way of illustration and not by limitation, metals and/or metal alloys. For example, suitable metals and/or metal alloys include, but are not limited to, medical grade stainless steels (304, 306, 308, 316L, 318, etc.), gold, platinum, platinum alloys, palladium, rhodium, tungsten, tungsten alloys, cobalt chrome, titanium and titanium alloys, and other metal alloys such as those composed of titanium/nickel and sold under the trade identifier “nitinol.” Other materials, such as polymer materials, may also be used. - Heat treatment of the nitinol alloy may also be desirable. An example of such a heat treatment includes, but is not limited to, placing the nitinol in its desired shape onto a mandrel. The nitinol is then heated to a temperature of 650°-750° F. for a predetermined time (e.g., two (2) to five (5) minutes), possibly (but not necessarily) annealing the constituent nitinol. After heat treatment, the
flexible cord 330 retains its shape and the nitinol alloy retains its super-elastic properties. - By way of example, the
cord 330 can be formed of a number of polymeric materials. For example, thecord 330 can be formed of, by way of illustration and not by limitation, thermoplastic and thermo-set polymers. Examples of these polymers include polyolefins such as polyethylene and polypropylene, polyesters such as Dacron, polyethylene terephthalate and polybutylene terephthalate, vinyl halide polymers such as polyvinyl chloride (PVC), polyvinylacetate such as ethyl vinyl acetate (EVA), polyurethanes, polymethylmethacrylate, pellethane, polyamides such asnylon 4, nylon 6, nylon 66, nylon 610,nylon 11, nylon 12 and polycaprolactam, polyaramids (e.g., KEVLAR), polystyrene-polyisobutylene-polystyrene (SIBS), segmented poly(carbonate-urethane), Rayon, fluoropolymers such as polytetrafluoroethylene (PTFE or TFE) or expanded polytetrafluoroethylene (ePTFE), ethylene-chlorofluoroethylene (ECTFE), fluorinated ethylene propylene (FEP), polychlorotrifluoroethylene (PCTFE), polyvinylfluoride (PVF), or polyvinylidenefluoride (PVDF), natural biopolymers such as cellulose, chitin, keratin, silk, and collagen, explanted veins, decellularized basement membrane materials, such as small intestine submucosa (SIS) or umbilical vein, or other naturally occurring extracellular matrix (ECM), and mixtures and copolymers thereof. SIS and ECM materials can be autologous, allogeneic or xenograft material derived from mammals, including sources, such as human, cattle, sheep, and porcine. - Each of the polymers noted herein may be used in conjunction with radiopaque filler materials such as barium sulfate, bismuth trioxide, bismuth carbonate, powdered tungsten, powdered tantalum, or the like so that the location of the
cord 330 may be radiographically visualized within the human body. - In another embodiment of the present invention, the polymers and blends that are used to form the composite can be used as a drug delivery matrix. To form this matrix, the polymer would be mixed with a therapeutic agent. The variety of different therapeutic agents that can be used in conjunction with the polymers of the present invention is vast. In general, therapeutic agents which may be administered via the pharmaceutical compositions of the invention include, without limitation: antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; anti-inflammatory agents; hormones such as steroids; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins. Matrix formulations may be formulated by mixing one or more therapeutic agents with the polymer. The therapeutic agent may be present as a liquid, a finely divided solid, or any other appropriate physical form. Typically, but optionally, the matrix will include one or more additives, such as diluents, carriers, excipients, stabilizers or the like. Additionally, radiopaque markers may be added to the composite to allow imaging of the composite after implantation.
- The
deployment rods cord 330 can also include a variety of cross-sectional configurations. For example, thedeployment rods cord 330 can have one or more of a round (e.g., circular, oval, and/or elliptical), ribbon, semi-circular triangular, tubular, I-shaped, T-shaped, and trapezoidal. With respect to “braid,” the term can include tubular constructions in which thecord 330 making up the construction are woven radially in an in-and-out fashion as they cross to form a tubular member defining a single lumen. The braid can also be constructed of flexible members of different widths. The embodiments, however, are not limited to the examples as other cross-sectional geometries are also possible. - In an additional embodiment, the
cord 330 can include a number of forms that contribute to both its mechanical and handling properties. Examples of such forms for thecord 330 include, but are not limited to, those selected from the group consisting of weaves, braids, meshes, knits, warped knitted (i.e., lace-like), and non-woven structures, as the same will be known and understood by one of ordinary skill in the art. In addition, mechanical properties of thecord 330 can be altered by changing the density, form, and/or texture in one or more locations along the length of thecord 330. Examples of such changes include alterations to the suitable structures used to create thecord 330 which can include, for example, monofilaments, yarns, threads, braids, or bundles of fibers. Regardless of its configuration, the structure of thecord 330 should possess a tensile strength adequate to withstand pressures (e.g., a stretching load) imposed by manipulating thecord 330, as discussed herein. - The first and second piercing
members members cord 330. The first and second piercingmembers members members members - The position of the
distal end 340 can also be adjusted in a variety of ways. For example, theelongate body 336 can have a variety of shapes and curves that would be selected for appropriate use given the anatomy at hand. In this example, theelongate body 336 could have one or more predetermined bends or curves to meet demands for the placement of thecatheter 334. - An additional embodiment could use a single curve design that can be modified by the operator during use of the
catheter 334. For example, thedelivery catheter 334 can further include athird lumen 360 extending from theproximal end 338 toward thedistal end 340 of thedelivery catheter 334. In one embodiment, thethird lumen 360 has a surface defining anopening 362 through awall 364 of thedelivery catheter 334. Theopening 362 can be positioned between thepredetermined bend 342 and theproximal end 338 of thedelivery catheter 334. - The
delivery catheter 334 can further include anadjustment member 366 extending from thethird lumen 360. As illustrated inFIG. 3 , theadjustment member 366 has anelongate body 368 having afirst end 370 and asecond end 372. In one embodiment, theadjustment member 366 extends through thethird lumen 360 with thefirst end 370 extending from thedelivery catheter 334 at or adjacent theproximal end 338 of thecatheter 334. In an additional embodiment, the second end of theadjustment member 366 can be coupled to thedelivery catheter 334 at a point between thepredetermined bend 342 and thedistal end 340 of thecatheter 334. - Applying tension (e.g., pulling and/or pushing) the
adjustment member 366 from thefirst end 370 allows thesecond end 372 to move, thereby changing thepredetermined bend 342. In other words, thepredetermined bend 342 can flex under tension applied through the adjustment member to allow thedistal end 340 to be positioned at a second predetermined location (discussed herein) adjacent the heart valve. When the tension on theadjustment member 366 is released, thepredetermined bend 342 returns towards its original configuration prior to being changed by theadjustment member 366. - The
second end 372 of theadjustment member 366 can be anchored into theelongate body 336 of thedelivery catheter 334 in a number of ways. For example, thesecond end 372 of theadjustment member 366 can be mechanically anchored into theelongate body 336 of thecatheter 334 with one or more barbs that resist/prevent thesecond end 372 of theadjustment member 366 from slipping or moving. Alternatively, thesecond end 372 of theadjustment member 366 can be secured to a cleat embedded in theelongate body 336 of thecatheter 334. In an additional embodiment, thesecond end 372 of theadjustment member 366 can be chemically fastened (e.g., glued) to theelongate body 336 of thecatheter 334. Combinations of these fastening methods, along with other fastening methods, are also possible. - The
adjustment member 366 can be moved longitudinally within thethird lumen 360 to change the position of thedistal end 340 of thedelivery catheter 334. For example, theadjustment member 366 can be pulled to provide tension at thesecond end 372 thereby reducing adistance 374 between thesecond end 372 and theopening 362 of thedelivery catheter 334. Theadjustment member 366 can also be used to push theelongate body 336 of thedelivery catheter 334, thereby increasing thedistance 374 between thesecond end 372 and theopening 362 of thedelivery catheter 334. The pushing and/or pulling of theadjustment member 366 allows for temporary changes in thepredetermined bend 342 and the relative position of thedistal end 340 of thedelivery catheter 334. In an additional embodiment, upon changing thepredetermined bend 342 and the relative position of thedistal end 340 of thedelivery catheter 334 theadjustment member 366 can be temporarily locked to allow the position of thedistal end 340 to be maintained. - The
adjustment member 366 can also be formed from a number of different materials in a number of different configurations. For example, theadjustment member 366 can be formed of, by way of illustration and not by limitation, metals and/or metal alloys, as recited herein. Other materials, such as various polymer recited herein, may also be used. As will be appreciated, other structural configurations that allow for altering the shape and/or the position of thepredetermined bend 342 and the relative position of thedistal end 340 of thedelivery catheter 334 are also possible. For example, a push-pull and/or torque wire(s) could be used with one or more lumens (e.g., the third lumen) that extend to thedistal end 340 of thedelivery catheter 334. The push or pull or push-pull wire(s) could then be use to provide a steerable catheter having a deflectable distal portion. As will be appreciated, a spring tube can also be provided at the distal portion of thedelivery catheter 334 for improved torque transmission and kink-resistance. Example of suitable mechanisms for accomplishing delivery catheter steering can also be found in U.S. Pat. No. 5,318,525 to West et al., herein incorporated by reference in its entirety. Other examples are also possible. - The
apparatus 332 can further include asheath 376 having alumen 378 large enough to receive and pass thedelivery catheter 334. In one embodiment, thesheath 376 can be used to introduce thedelivery catheter 334 into the heart, as will be discussed herein. Briefly, thesheath 376 can be introduced into and passed through the vasculature to position adistal end 380 of thesheath 376 into or adjacent a chamber of the heart. For example, thedistal end 380 of thesheath 376 could be positioned across or adjacent the aortic valve. Thedelivery catheter 334 could then be extended from thesheath 376 to position thedistal end 340 of thedelivery catheter 334 at or adjacent the mitral valve of the heart from within the left ventricle of the heart. As will be appreciated, there are other locations that thedistal end 380 of thesheath 376 could be positioned to allow access and positioning of thedistal end 340 of thedelivery catheter 334. In addition, it is appreciated that thesheath 376 can have one or more predetermined bends (i.e., a predetermined shape) that would allow for access and positioning of thedistal end 340 of thedelivery catheter 334 within the heart. - The
sheath 376 can also be used to house thedelivery catheter 334 upon its removal from the body. For example, thedelivery catheter 334 can be retracted back into thelumen 378. In one embodiment, thedistal end 380 of thesheath 376 is configured to assist in allowing thepredetermined bend 342 in theelongate body 336 to straighten out as thedelivery catheter 334 is retracted back into thelumen 378. For example, thedistal end 380 of thesheath 376 can have a funnel like flare to allow theelongate body 336 not to “catch” on thedistal end 380 of thesheath 376 as thepredetermined bend 342 moves into thelumen 378. - In the various embodiments of the present invention, the elongate body of the
delivery catheter 334 and thesheath 376 can be formed from a variety of materials and in a variety of configurations. For example, the materials may include, but are not limited to, polymer and polymer blends. Examples of such materials include, but are not limited to, polyurethane (PU), polyvinyl chloride (PVC), polyethylene (PE), polyolefin copolymer (POC), polyethylene terephthalate (PET), polyamid, mixtures, and block co-polymers thereof. As will be appreciated, selection of the material can be based generally on a broad range of technical properties, including, but not limited to, modulus of elasticity, flexural modulus, and Shore A hardness required for the embodiments of the present invention. Components of the present apparatus and/or system can also be coated for lubrication, for abrasion resistance, or to deliver one or more drugs and/or therapeutic agents. - In an additional embodiment,
delivery catheter 334 can further include radiopaque markers. For example, radiopaque markers (e.g., attached, integrated, and/or coated), as discussed herein, can be used to mark the location of the first piercingmember 344 and the second piercingmember 346. In addition, radiopaque markers can be used to mark the location ofcord 330. Other portions ofdelivery catheter 334 can also be marked with radiopaque markers as necessary to allow for visualization of the orientation and positioning of thedelivery catheter 334. - Now referring to
FIGS. 4A-4F , there is provided an illustration of an embodiment of anapparatus 482 according to the present invention. Theapparatus 482 includes a receivingcatheter 484 having anelongate body 486 with aproximal end 488 and adistal end 490. The receivingcatheter 484 also includes apredetermined bend 492 positioned between the proximal anddistal ends elongate body 486. As discussed herein, thedistal end 490 can be adjusted in a variety of ways. For example, theelongate body 486 can have a variety of shapes and curves that would be selected for appropriate use given the anatomy at hand. Alternatively, the position of thedistal end 490 can be adjusted by the operator during use of thecatheter 484, as discussed herein. - The receiving
catheter 484 is adapted, as discussed herein, to interact with thecord 430, including the first and second piercingmembers 444, shown inFIG. 4A , and 446, shown inFIG. 4D . The receivingcatheter 484 includes afirst lumen 494, asecond lumen 496, athird lumen 498, and afourth lumen 401. In one embodiment, the first, second, andthird lumens elongate body 486 from theproximal end 488 to thedistal end 490 of the receivingcatheter 484. Thefourth lumen 401 extends from theproximal end 488 toward thedistal end 490 of the receivingcatheter 484. In one embodiment, thefourth lumen 401 has a surface defining anopening 403 through awall 405 of the receivingcatheter 484. Theopening 403 can be positioned between thepredetermined bend 492 and theproximal end 488 of the receivingcatheter 484. - The receiving
catheter 484 also includes anadjustment member 407 extending from thefourth lumen 401. As illustrated inFIGS. 4A-4F , theadjustment member 407 has anelongate body 409 having afirst end 411 and asecond end 413. In one embodiment, theadjustment member 407 extends through thefourth lumen 401 with thefirst end 411 extending from the receivingcatheter 484 at or adjacent theproximal end 488 of thecatheter 484. In an additional embodiment, the second end of theadjustment member 407 can be coupled to the receivingcatheter 484 at a point between thepredetermined bend 492 and thedistal end 490 of thecatheter 484. In one embodiment, theadjustment member 407 can be anchored/coupled to the receivingcatheter 484 as discussed above foradjustment member 366 illustrated inFIG. 3 . In addition, theadjustment member 407 can be used to apply tension (e.g., pulling and/or pushing) from thefirst end 411 to allow thesecond end 413 to move, thereby changing thepredetermined bend 492 in a similar manner as discussed above foradjustment member 366 illustrated inFIG. 3 . - The
adjustment member 407 can also be formed from a number of different materials in a number of different configurations. For example, theadjustment member 407 can be formed of, by way of illustration and not by limitation, metals and/or metal alloys, as recited herein. Other materials, such as various polymer recited herein, may also be used. - As will be appreciated, other structural configurations that allow for altering the shape and/or the position of the
predetermined bend 492 and the relative position of thedistal end 490 of thecatheter 484 are also possible. For example, a push or pull or push-pull wire could be used with one or more lumen(s) (e.g., the fourth lumen) that extend to thedistal end 490 of thecatheter 484. As will be appreciated, other structural configurations that allow for altering the shape arid/or the position of thepredetermined bend 492 and the relative position of thedistal end 490 of the receivingcatheter 484 are also possible, such as those discussed herein in connection withFIG. 3 . - The receiving
catheter 484 further includes arelease member 417 extending through thethird lumen 498. Therelease member 417 includes anelongate body 419 having afirst end 421 and asecond end 423. In one embodiment, therelease member 417 encircles thewall 405 of theelongate body 486 between thedistal end 490 and acoupling device 425. As will be discussed herein, thecoupling device 425 is used to join thecord 430 to form a loop. Thecoupling device 425 can then separate from the receivingcatheter 484 through the use of therelease member 417. - As illustrated in
FIG. 4A , therelease member 417 extends from thedistal end 490 towards thewall 405 of the receivingcatheter 484. In one embodiment, therelease member 417 loops around the perimeter of thewall 405 perpendicularly to theelongate body 486. Therelease member 417 crosses itself where it emerges at thewall 405, returning towards thethird lumen 498. In this way, therelease member 417 completely encircleselongate body 486. Thesecond end 423 of therelease member 417 then couples to theelongate body 486 at or adjacent thethird lumen 498 of the receivingcatheter 484. Thecoupling device 425 can then be separated from theelongate body 486 of the receivingcatheter 484 by applying sufficient tension (e.g., pulling) to therelease member 417 so that it creates a cut between the throughcoupling device 425 and theelongate body 486 of the receivingcatheter 484.FIG. 4F illustrates an embodiment in which therelease member 417 has been used to separate thecoupling device 425 and theelongate body 486 of the receivingcatheter 484. - In one embodiment, to better ensure that the cut occurs between the
coupling device 425 and theelongate body 486 of the receivingcatheter 484, thedistal end 490 of theelongate body 486 can be formed of a material that is harder (e.g., metal and/or polymer) than the material through which therelease member 417 cuts. Similarly, thecoupling device 425 can also be formed of a harder material than the material through which therelease member 417 cuts. So, there can be a laminar structure in which both thedistal end 490 of theelongate body 486 and thecoupling device 425 are constructed of a first material and a second sacrificial material, softer than the first material, is used to connect thecoupling device 425 to theelongate body 486. Therelease member 417 can then travel more easily through the second sacrificial material thereby better ensuring a clean separation of theelongate body 486 and thecoupling device 425. - Other release mechanisms for separating the
release member 417 and thecoupling device 425 are also possible. For example, thesecond end 423 of therelease member 417 can include a threaded portion that releasably engages a threaded socket in thecoupling device 425. In this embodiment, the threaded engagement of therelease member 417 holds thecoupling device 425 to the receivingcatheter 484 until torque is applied to therelease member 417 to disengage the threaded connection with thecoupling device 425. Once the threaded connection is disengaged, thecoupling device 425 would be free of the receivingcatheter 484. Other releasable coupling mechanisms are also possible, including the use of an electrolytic release mechanism. - The
release member 417 can be constructed of a variety of materials and in a variety of configurations. For example, therelease member 417 can be formed of, by way of illustration and not by limitation, metals and/or metal alloys, such as those discussed herein. Alternatively, therelease member 417 can be formed from a number of polymeric materials, such as from many of those discussed herein. Thedeployment release member 417 can also include a variety of cross-sectional configurations. For example, therelease member 417 can have one or more of a round (e.g., circular, oval, and/or elliptical), ribbon, semi-circular triangular, tubular, I-shaped, T-shaped, and trapezoidal. As will be appreciated, therelease member 417 has a cross-sectional size that provides both sufficient strength and flexibility to perform its functions described herein. - The receiving
catheter 484 further includes first retrievingmembers 427 and second retrievingmembers 429. Each of the first and second retrievingmembers multiple fingers 431 that can be extended through first andsecond openings coupling device 425. In one embodiment, as thefingers 431 extend from the first andsecond openings fingers 431 for the piercing member. For example, as illustrated inFIG. 4B thefingers 431 have been extended from thefirst opening 433. Thefingers 431 have flared open to create the receiving area into which at least part of the piercingmember 444 can be positioned. In one embodiment, the ends of thefingers 431 can be bent towards the center of the receiving area (e.g., hooked) to allow thefingers 431 to better engage the piercingmember 444. - As illustrated, the
fingers 431 can be extended from and retracted into theelongate body 486 of the receivingcatheter 484 through the use of thefingers 431 that extend through the first andsecond lumen elongate body 486. In one embodiment, thefingers 431 can be braided together to form ashaft 437 that extends through theproximal end 488 of the receivingcatheter 484 to a predetermined location along theshaft 437. At the predetermined location, thefingers 431 transition from the braided structure into an aligned configuration in which thefingers 431 longitudinally extend in a radial fashion through the first andsecond lumens shaft 437 need not be formed from portions of thefingers 431. For example, theshaft 437 could be a member having one or more cross-sectional configurations described herein onto which thefingers 431 are coupled (e.g., welded). As illustrated, thefingers 431 have predetermined bends so the receiving area can be formed upon extending thefingers 431 from the receivingcatheter 484. - Once captured, the
shaft 437 can be pulled to draw thefingers 431, the first piercingmember 444 and thecord 430 through thefirst opening 433 of thecoupling device 425 and into thefirst lumen 494. This process is illustrated inFIGS. 4A-4C . The receivingcatheter 484 can then be used to capture and retain the second piercingmember 446 and thecord 430 in a similar manner. For example,FIGS. 4D and 4E illustrate thefingers 431 being extended from thesecond opening 433 in thecoupling device 425 using theshaft 439. Once captured, the second piercingmember 446 and thecord 430 can be drawn through thesecond opening 435 of thecoupling device 425. The length of thecord 430 can then be adjusted (e.g., shortened) depending upon how far one or both of the first and/or second piercingmembers cord 430 are drawn into thelumens catheter 484. - The
fingers 431 andshafts fingers 431 andshafts - As discussed herein, the
coupling device 425 includes thefirst opening 433 and thesecond opening 435. In one embodiment, thefirst opening 433 and thesecond opening 435 are defined bytabs 441. For example, each of theopenings more tabs 441 that form a part of thecoupling device 425. In one embodiment, as thefingers 431 having retrieved the piercingmember cord 430 is drawn into thelumen tabs 441 flex or bend to allow the structures to pass through the opening. Once the motion stops, however, thetabs 441 return to their un-flexed state to at least partially engage a structure located in the opening. For example, theopenings cord 430 thereby preventing thecord 430 from being drawn out of the opening once it has entered. In other words, thetabs 441 can function to form a one-way path for thecord 430 being drawn into either of thelumens - In one embodiment, once the
cord 430 has been draw into theopenings cord 430 can then be adjusted by drawing thecord 430 though the “one-way”openings release member 417 can be used to separate thecord 430 in its looped configuration and thecoupling device 425 from theelongate body 486 of the receivingcatheter 484. In other words, therelease member 417 is able to cut thecord 430 along with the material connecting thecoupling device 425 and theelongate body 486 of the receivingcatheter 484. An illustration of this can be seen inFIG. 4F . - The
elongate body 486 of receivingcatheter 484 can have various lengths between theproximal end 488 and thedistal end 490. In one embodiment, the length between theproximal end 488 and thedistal end 490 can be sufficient to allow the receivingcatheter 484 to be percutaneously implanted through a patient's vasculature to position thedistal end 490 at a predetermined location. Examples of the predetermined locations include, but are not limited to, cardiovascular locations such as on or adjacent to a cardiac valve of the heart (e.g., the mitral valve), including within a chamber of the patient's heart (e.g., the left atrium of the heart). As discussed above, the length between theproximal end 488 and thedistal end 490 will be dependent upon each patient's physiological structure and the predetermined location within the patient. - Referring now to
FIGS. 5A-5F , there is shown an embodiment of theapparatus 532 including both thesheath 576 and thedelivery catheter 534. As discussed herein, thedelivery catheter 534 can be used to position and deliver thecord 530. Thecord 530 can then be formed into a loop, the length of which can be adjusted to modify the configuration of the heart valve in such as way as to induce coaptation of the valve leaflets. - In one embodiment, the
cord 530 can be formed into a loop (illustrated inFIG. 2 ) having a closed circumference around a cardiac valve and positioned perpendicular to a plane of coaptation of the valve leaflets. The closed circumference of the loop can then be adjusted to provide a constraining effect on the valve leaflets perpendicularly to the plane of coaptation. Constraining the valve leaflets in this way can create a valve having a double orifice, which in turn, can help to reduce regurgitation through the cardiac valve, such as mitral valve regurgitation as discussed herein. - Referring now to
FIG. 5A there is illustrated one embodiment of theapparatus 532 positioned within a cardiovascular system. In various embodiments, methods for modifying a cardiac valve can include positioning thedelivery catheter 534 adjacent a heart valve. In one embodiment, positioning thedelivery catheter 534 can include positioning the delivery catheter adjacent the fibrous ring surrounding the heart valve. - Specifically, the
sheath 576 and thedelivery catheter 534 are placed in such a way as to position thedistal end 540 of thedelivery catheter 534 at or adjacent a heart valve. In the present example, the heart valve is themitral valve 514 located between the left atrium chamber (first chamber 502) and the left ventricle chamber (second chamber 504) of the heart 500. As will be appreciated, thedelivery catheter 534 could be positioned at or adjacent another heart valve. Orientation and visualization of the various components and structures discussed herein may be accomplished through the use of any combination of echogenic, angioscopic, ultrasound and fluoroscopic visualization techniques. - Once in position, the
delivery catheter 534 can then be used to pass thefirst end 552 of thecord 530 between the second heart chamber 504 (the left ventricle in this example) and the first heart chamber 502 (the left atrium in this example). To accomplish this, thesheath 576 can be introduced percutaneously into the arterial portion of the vasculature. In the present embodiment, thedistal end 580 of thesheath 576 can be positioned across theaortic valve 516. Thedelivery catheter 534 can then be extended from the lumen 578 of thesheath 576, where upon emerging from the lumen 578 thepredetermined bend 542 of thedelivery catheter 534 can be reestablished. - The
distal end 540 can then be positioned at a firstpredetermined location 543 by moving one or both the elongate body 536 of thedelivery catheter 534 and theadjustment member 566, as discussed herein. In one embodiment, thedistal end 540 of thedelivery catheter 534 can be moved between thechordae tendineae 510 of themitral valve 514 in positioning thedistal end 540 of thedelivery catheter 534 at or adjacent the firstpredetermined location 543 of the heart valve. - For example, the
distal end 540 can be positioned at or adjacent aposterior portion 545 of afibrous ring 547 surround the heart valve, such as the posterior mitral annulus of themitral valve 514. Once in position, the first deployment rod can be used to extend the first piercingmember 544 and thecord 530 from thedelivery catheter 534. In one embodiment, the first piercingmember 544 and a first portion of thecord 530 can be positioned within thefibrous ring 547 using the first deployment rod so at least the first piercingmember 544 extends at least partially within thefirst heart chamber 502. -
FIG. 5B illustrates a cross-sectional view of themitral valve 514 taken along theline 5B-5B inFIG. 5A .FIG. 5B illustrates a view of themitral valve 514 as seen from within from the left ventricle. As illustrated, thedelivery catheter 534 extends from theaortic valve 516 to position thedistal end 540 of thecatheter 534 adjacent thefibrous ring 547 and themitral annulus 524. This view of thecatheter 534 also provides a further illustration of the implant location for the first piercingmember 544 that allows thecord 530 to be positioned perpendicular to the plane ofcoaptation 551 of themitral valve 514. - The
distal end 540 can then be re-positioned, as illustrated inFIG. 5C , to a secondpredetermined location 553. In one embodiment, re-positioning to the secondpredetermined location 553 can be accomplished by moving one or both the elongate body 536 of thedelivery catheter 534 and theadjustment member 566, as discussed herein. In the present example, the secondpredetermined location 553 can be ananterior portion 549 of thefibrous ring 547 surrounding the heart valve. In re-positioning, thecord 530 can also be positioned between at least a portion of thechordae tendineae 510 attached to leaflets of the heart valve with thedelivery catheter 534. Once in position, the second piercingmember 546 and a second portion of thecord 530 can be positioned within thefibrous ring 547 using the second deployment rod so at least the second piercingmember 546 extends at least partially within thesecond heart chamber 504. -
FIG. 5D illustrates a cross-sectional view of the mitral valve taken along theline 5D-5D inFIG. 5C .FIG. 5D illustrates a view of themitral valve 514 as seen from within from the left ventricle. As illustrated, thedelivery catheter 534 extends from theaortic valve 516 to position thedistal end 540 of thecatheter 534 adjacent thefibrous ring 545 and themitral annulus 524. This view of thecatheter 534 also provides a further illustration of the implant location for the second piercingmember 546 that allows thecord 530 to be positioned perpendicular to the plane ofcoaptation 551 of themitral valve 514. - Once the second piercing
member 546 and the second portion of thecord 530 are positioned within thefibrous ring 547, thedelivery catheter 534 can be retracted back into thesheath 576, and theapparatus 532 removed from the vasculature.FIGS. 5E and 5F provide an illustration of this embodiment. - Referring now to
FIGS. 6A-6F , there is shown an embodiment of theapparatus 682 including both asheath 655 and the receivingcatheter 684. As discussed herein, the receivingcatheter 684 can be used to interact with thecord 630, including the first and second piercingmembers catheter 684 can also be used in forming thecord 630 into a loop that can be separated from the receivingcatheter 684. In addition to forming the loop, the receivingcatheter 684 can also be used in adjusting the length of thecord 630 forming the loop to modify the configuration of the heart valve in such as way as to induce coaptation of the valve leaflets. - Referring now to
FIG. 6A there is illustrated one embodiment of theapparatus 682 positioned within a cardiovascular system. In various embodiments, methods for modifying a cardiac valve can include positioning the receivingcatheter 684 adjacent a heart valve. In one embodiment, positioning the receivingcatheter 684 can include positioning the delivery catheter adjacent the fibrous ring surrounding the heart valve. - Specifically, the
sheath 655 and the receivingcatheter 684 are placed in such a way as to position thedistal end 690 of the receivingcatheter 684 at or adjacent a heart valve in thefirst heart chamber 602, such as themitral valve 614. To accomplish this, thesheath 655 can be introduced percutaneously into the left atrium (the first heart chamber 602) by crossing theinteratrial septum 657. The receivingcatheter 684 can then be extended from thesheath 655 to position thedistal end 690 adjacent the heart valve. - As will be appreciated, the receiving
catheter 684 could be positioned at or adjacent another heart valve. Orientation and visualization of the various components and structures discussed herein may be accomplished through the use of any combination of echogenic, angioscopic, ultrasound and fluoroscopic visualization techniques. - The
distal end 690 can then be positioned adjacent the first piercingmember 644 and/or thecord 630 by either selecting the appropriate shaped elongate body and/or moving one or both the elongate body 686 of the receivingcatheter 684 and theadjustment member 607, as discussed herein. Once in position, the receivingcatheter 684 can then be used to capture the first piercingmember 644 and/or at least a first portion of thecord 630. In one embodiment, the fingers of the receivingcatheter 684 can be used to capture and draw the first piercingmember 644 and/or at least a first portion of thecord 630 into the first opening of the coupling device, as discussed herein.FIG. 6A provides an illustration of the first piercingmember 644 being captured and drawn into the receivingcatheter 684. -
FIG. 6B illustrates a cross-sectional view of the mitral valve taken along theline 6B-6B inFIG. 6A .FIG. 6B illustrates a view of themitral valve 614 as seen from within from the left atrium. As illustrated, the receivingcatheter 684 extends from thesheath 655 to position thedistal end 690 of thecatheter 684 adjacent thefibrous ring 647 and themitral annulus 624. This view of thecatheter 684 also provides a further illustration of the implant location for the first piercingmember 644 that allows thecord 630 to be positioned perpendicular to the plane ofcoaptation 651 of themitral valve 614. - The
distal end 690 can then be re-positioned, as illustrated inFIG. 6C , adjacent the second piercingmember 646 and/or thecord 630 by moving one or both the elongate body 686 of the receivingcatheter 684 and theadjustment member 607, as discussed herein. Once in position, the receivingcatheter 684 can then be used to capture the second piercingmember 646 and/or at least a second portion of thecord 630. In one embodiment, the fingers of the receivingcatheter 684 can be used to capture and draw the second piercingmember 646 and/or at least a second portion of thecord 630 into the second opening of the coupling device, as discussed herein.FIG. 6C provides an illustration of the second piercingmember 646 being captured and drawn into the receivingcatheter 684. -
FIG. 6D illustrates a cross-sectional view of the mitral valve taken along theline 6D-6D inFIG. 6C .FIG. 6D illustrates a view of themitral valve 614 as seen from within from the left atrium. As illustrated, the receivingcatheter 684 has drawn thecord 630 perpendicularly across the plane ofcoaptation 651 of themitral valve 614. - Once the second piercing
member 646 and the second portion of thecord 630 are captured and drawn into the receiving catheter 684 a loop having a closed circumference is formed. The length of the loopedcord 630 can then be manipulated (e.g., adjusting the length) so as to alter the configuration of the heart valve so as to induce the leaflets of the heart valve to coapt. In one embodiment, adjusting the length of thecord 630 can be used to adjust the tension of thecord 630 so as to apply force to the anterior and posterior portion of the fibrous ring of the heart valve. - Adjusting tension of the
cord 630 through the receivingcatheter 684, as discussed herein, can be used to modify the configuration of the heart valve. In one embodiment, altering the configuration of the heart valve includes constraining the elongate portion of the valve leaflets of the heart valve perpendicularly to the plane of coaptation so as to create a double orifice through an opening of themitral valve 614. Thecord 630 in its loop form, along with the coupling device, can then be released from the receivingcatheter 684 through the use of the release member, as discussed herein. - The present invention further includes a medical system. In one embodiment, the medical system of the present invention includes both the
apparatus 332, as illustrated inFIG. 3 , and theapparatus 482, as illustrated inFIGS. 4A-4F . - While the present invention has been shown and described in detail above, it will be clear to the person skilled in the art that changes and modifications may be made without departing from the scope of the invention. As such, that which is set forth in the foregoing description and accompanying drawings is offered by way of illustration only and not as a limitation. The actual scope of the invention is intended to be defined by the following claims, along with the full range of equivalents to which such claims are entitled.
- In addition, one of ordinary skill in the art will appreciate upon reading and understanding this disclosure that other variations for the invention described herein can be included within the scope of the present invention. For example, the delivery and receiving catheters can be coated with a non-thrombogenic biocompatible material, as are known or will be known.
- In the foregoing Detailed Description, various features are grouped together in several embodiments for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the embodiments of the invention require more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment. Thus, the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separate embodiment.
Claims (18)
1. A method, comprising:
positioning a delivery catheter adjacent a fiberous ring surrounding a heart valve;
positioning a receiving catheter adjacent the fiberous ring surrounding the heart valve, the receiving catheter having a coupling device;
passing a first piercing member and a first portion of a cord from the delivery catheter through the fiberous ring;
extending a first capture device from the receiving catheter;
capturing the first piercing member that extends through the fiberous ring with the first capture device;
passing a second piercing member and a second portion of the cord from the delivery catheter through the fiberous ring;
extending a second capture device from the receiving catheter;
capturing the second piercing member that extends through the fiberous ring with the second capture device;
connecting the first portion and the second portion of the cord with the coupling device to form a loop; and
releasing the loop and at least a portion of the coupling device from the receiving catheter.
2. The method of claim 1 , where connecting the first portion and the second portion of the cord includes altering a configuration of the heart valve in forming the loop.
3. The method of claim 2 , wherein altering the configuration of the heart valve includes constraining an elongate portion of a leaflet of the heart valve perpendicularly to a plane of coaptation for the leaflet.
4. The method of claim 2 , wherein altering the configuration of the heart valve includes adjusting tension of the cord; and
joining portions of the cord at or adjacent a first end and a second end of the cord.
5. The method of claim 4 , wherein adjusting tension of the cord applies force to an anterior and posterior portion of the fibrous ring of the heart valve.
6. The method of claim 2 , wherein positioning the delivery catheter and the receiving catheter adjacent the heart valve includes positioning the delivery catheter and the receiving catheter adjacent a mitral valve.
7. The method of claim 6 , wherein altering the configuration of the heart valve includes altering the configuration of the mitral valve to create a double orifice through an opening of the mitral valve.
8. The method of claim 1 , wherein connecting the first portion and the second portion of the cord with the coupling device to form the loop includes adjusting a length of the loop to constrain an elongate portion of a leaflet of the heart valve perpendicularly to a plane of coaptation for the leaflet.
9. The method of claim 1 , wherein passing the first piercing member and the first portion of the cord includes passing the first piercing member and the first portion of the cord through a posterior portion of the fibrous ring surrounding the heart valve.
10. The method of claim 9 , wherein passing the second piercing member and the second portion of the cord includes passing the second piercing member and the second portion of the cord through an anterior portion of the fibrous ring surrounding the heart valve.
11. A method, comprising:
positioning a delivery catheter adjacent a fibrous ring surrounding a heart valve;
positioning a cord between at least a portion of chordae tendineae attached to leaflets of the heart valve with the delivery catheter;
advancing the cord through the fibrous ring surrounding the heart valve; and
modifying a configuration of the heart valve with the cord to induce the leaflets of the heart valve to coapt.
12. The method of claim 11 , wherein positioning the delivery catheter further includes:
positioning the distal end of delivery catheter at a first predetermined location and delivering a first portion of the cord to the first predetermined location; and
positioning the distal end of the delivery catheter at a second predetermined location and delivering a second portion of the cord to the second predetermined location.
13. The method of claim 12 , wherein the first predetermined location includes a posterior portion of the fibrous ring, and wherein the second predetermined location includes an anterior portion of the fibrous ring.
14. The method of claim 13 , wherein positioning the delivery catheter at the anterior fibrous ring includes moving the delivery catheter between the chordae tendineae.
15. The method of claim 14 , wherein moving the delivery catheter between the chordae tendineae further includes adjusting the delivery catheter from the first predetermined location to the second predetermined location using an adjustment member coupled to the delivery catheter.
16. The method of claim 11 , wherein advancing the cord includes advancing the cord through an anterior and a posterior portion of the fibrous ring between a first heart chamber and a second heart chamber such that a first portion and a second portion of the cord extend into the first heart chamber.
17. The method of claim 16 , wherein modifying further includes:
positioning a receiving catheter adjacent the fibrous ring surrounding the heart valve in the second heart chamber; and
capturing the first and second portions of the cord with the receiving catheter.
18. The method of claim 17 , wherein modifying further includes:
applying force to the cord through the receiving catheter to modify the configuration of the heart valve; and
connecting the cord with the receiving catheter to form a loop having a closed circumference.
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WO (1) | WO2007084726A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US7799038B2 (en) | 2010-09-21 |
WO2007084726A2 (en) | 2007-07-26 |
WO2007084726A3 (en) | 2007-09-07 |
EP1976439B1 (en) | 2015-07-29 |
CA2637235A1 (en) | 2007-07-26 |
JP2009523558A (en) | 2009-06-25 |
EP1976439A2 (en) | 2008-10-08 |
US20070173930A1 (en) | 2007-07-26 |
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