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Publication numberUS20090259213 A1
Publication typeApplication
Application numberUS 12/491,531
Publication date15 Oct 2009
Filing date25 Jun 2009
Priority date21 Nov 2006
Also published asUS20080119823, US20150038789
Publication number12491531, 491531, US 2009/0259213 A1, US 2009/259213 A1, US 20090259213 A1, US 20090259213A1, US 2009259213 A1, US 2009259213A1, US-A1-20090259213, US-A1-2009259213, US2009/0259213A1, US2009/259213A1, US20090259213 A1, US20090259213A1, US2009259213 A1, US2009259213A1
InventorsJustin M. Crank
Original AssigneeCrank Justin M
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Injection tube for jet injection device
US 20090259213 A1
Abstract
A non-metal, polymeric tubular device for delivering a therapeutic fluid to a treatment site within a patient. The non-metal, polymeric tubular device can be fabricated using suitable high strength polymers and in some versions can be reinforced through the inclusion of reinforcement materials or braiding. The non-metal, polymeric tubular device can be fabricated so as to have a burst strength exceeding at least about 2,000 psi. The non-metal, polymeric tubular device can be fabricated so as to have distention properties, wherein an orifice or jet port located at a distal end of the polymeric tubular device retains its shape and/or size without suffering swelling that can have a detrimental impact on a fluid jet used to deliver the therapeutic fluid at the treatment site.
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Claims(29)
1-16. (canceled)
17. A method for delivering a therapeutic fluid to a treatment location with a non-metal, polymeric tubular device comprising:
providing a non-metal, polymeric applicator body having a distal end and a proximal connection end, wherein an administration orifice is positioned proximate the distal end, and wherein the applicator body comprises polymer selected from the group consisting of: a polyimide polymer, a polyetherimide polymer, and a linear aromatic polymer;
positioning the administration orifice proximate a treatment location; and
generating a fluid jet through the administration orifice for dispensing a therapeutic fluid at the treatment location.
18. The method of claim 17, further wherein:
the non-metal, polymeric applicator body comprises reinforcing materials.
19. The method of claim 17, further wherein:
the non-metal, polymeric applicator body comprises reinforcing fiber.
20. The method of claim 17, wherein generating the fluid jet comprises pressurizing the therapeutic fluid with an injector attached to the proximal connection end.
21. The method of claim 17 wherein the applicator body has a burst pressure of at least about 2,000 psi.
22. The method of claim 17 wherein the applicator body comprises polyether ether ketone.
23. The method of claim 17 wherein the applicator body is formed of non-reinforced polyether ether ketone polymer.
24. The method of claim 17 wherein the applicator body is formed of reinforced polyether ether ketone polymer.
25. The method of claim 17 comprising placing the applicator body in a patient's urogenital tract.
26. The method of claim 17 comprising passing the applicator body within a urethra.
27. The method of claim 17 wherein the treatment location comprises tissue of a bladder.
28. The method of claim 17 comprising injecting therapeutic fluid into tissue at the treatment location.
29. The method of claim 17 wherein the applicator body comprises a polymeric tubular device comprising sidewalls defining a lumen, the sidewalls and lumen terminating at a distal lumen end, wherein the distal lumen end is closed and the administration orifice is a bore through the sidewall, the bore being located along a length of the tubular device on a proximal side of the distal lumen end.
30. The method of claim 29 wherein the applicator body comprises polyether ether ketone, the method comprising placing the applicator body in a patient's urethra and injecting therapeutic fluid into tissue at the treatment location.
31. The method of claim 30 wherein the treatment location comprises tissue of a bladder.
32. A method for delivering a therapeutic fluid to a treatment location with a non-metal, polymeric tubular device comprising:
providing a non-metal, polymeric applicator body having a distal end and a proximal connection end, wherein an administration orifice is positioned proximate the distal end;
positioning the administration orifice proximate a treatment location; and
generating a fluid jet comprising therapeutic fluid through the administration orifice to inject therapeutic fluid into tissue at the treatment location.
33. The method of claim 32 comprising placing the applicator body in a patient's urogenital tract.
34. The method of claim 32 wherein the treatment location comprises tissue of a bladder.
35. The method of claim 32 wherein the applicator body comprises a polymeric tubular device comprising sidewalls defining a lumen, the sidewalls and lumen terminating at a distal lumen end, wherein the distal lumen end is closed and the administration orifice is a bore through the sidewall, the bore being located along a length of the tubular device on a proximal side of the distal lumen end.
36. The method of claim 35 wherein the applicator body comprises polyether ether ketone, the method comprising placing the applicator body in a patient's urethra and injecting therapeutic fluid into tissue at the treatment location.
37. A method for delivering a therapeutic fluid to a treatment location with a non-metal, polymeric tubular device comprising:
providing a non-metal, polymeric applicator body having a distal end and a proximal connection end, wherein an administration orifice is positioned proximate the distal end, and wherein the applicator body has a burst pressure of at least about 2,000 psi;
positioning the administration orifice proximate a treatment location; and
generating a fluid jet through the administration orifice for dispensing a therapeutic fluid at the treatment location.
38. The method of claim 37 comprising placing the applicator body in a patient's urogenital tract.
39. The method of claim 37 wherein the treatment location comprises tissue of a bladder.
40. The method of claim 37 wherein the applicator body comprises a polymeric tubular device comprising sidewalls defining a lumen, the sidewalls and lumen terminating at a distal lumen end, wherein the distal lumen end is closed and the administration orifice is a bore through the sidewall, the bore being located along a length of the tubular device on a proximal side of the distal lumen end.
41. The method of claim 37 wherein the applicator body comprises polyether ether ketone, the method comprising placing the applicator body in a patient's urethra and injecting therapeutic fluid into tissue at the treatment location.
42. The method of claim 17 wherein during generating a fluid jet through the administration orifice, dimensional characteristics of the administration orifice remain constant under the influence of the fluid jet.
43. The method of claim 32 wherein during generating a fluid jet through the administration orifice, dimensional characteristics of the administration orifice remain constant under the influence of the fluid jet.
44. The method of claim 37 wherein during generating a fluid jet through the administration orifice, dimensional characteristics of the administration orifice remain constant under the influence of the fluid jet.
Description
    PRIORITY CLAIM
  • [0001]
    The present application claims priority to U.S. Provisional Patent Application No. 60/866,741, filed Nov. 21, 2006 and entitled, “INJECTION TUBE FOR JET INJECTION DEVICE, which is herein incorporated by reference in its entirety.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention relates generally to jet injection devices for the delivery of therapeutic fluids to a treatment site. More specifically, the present invention relates to a non-metal reinforced polymeric injection tube having performance characteristics compatible with minimally invasive jet injection devices.
  • BACKGROUND OF THE INVENTION
  • [0003]
    A wide variety of medical treatments are at least partially performed through the delivery and introduction of therapeutic compositions to a treatment location. In home or outpatient settings, typical delivery methods can comprise oral delivery, via liquid or solid forms, as well as a variety of inhalant style devices. In clinical or hospital settings, therapeutic fluids can be injected using needle based or in some minimally invasive procedures, the therapeutic fluid can be delivered through a tubular device such as a catheter or endoscope based systems.
  • [0004]
    One way in which therapeutic fluids can be delivered internally is through the use of a tubular device configured to provide a jet-injection of the therapeutic fluid at a desired treatment site. Generally, a remote injector is utilized to deliver the therapeutic fluid from an external reservoir located at a proximal end of the tubular device such administration can occur at a distal end of the tubular device. Due to the relatively long travel length of the therapeutic fluid through the tubular device, the remote injector must generally be capable of pressurizing the therapeutic fluid to pressures exceeding about 2,000 psi. In order to accommodate these pressures, the tubular devices have been fabricated of alloys such as NiTi or stainless steel or with metal-reinforced polymers such as the braided tubes typically found in catheters. While the use of alloys and metal reinforced polymers satisfy the operational requirements related to burst pressure and distention strength, they are generally of limited flexibility making them difficult to navigate within the tortuous paths often found in the human body such as, for example, the urogenital tract.
  • SUMMARY OF THE INVENTION
  • [0005]
    The present invention comprises a non-metal, polymeric tubular device for delivering a therapeutic fluid to a treatment site within a patient. The non-metal, polymeric tubular device can be fabricated using suitable high strength polymers including, for example, polyimide, polyetherimide available from General Electric under the trade name UltemŽ and linear aromatic polymers such as PEEK™ available from Victrex plc. In some embodiments, the non-metal, polymeric tubular device can be reinforced through the inclusion of materials including nano-particles, clays and/or glass. In some presently contemplated embodiments, the non-metal, polymeric tubular device can be reinforced with one or more polymers such as, for example, tubes braided with carbon fiber, synthetic para-aramid fiber such as Kevlar available from E.I. du Pont de Nemours and Company or other high-strength polymers. The non-metal, polymeric tubular device can be fabricated so as to have a burst strength exceeding at least about 2,000 psi and in some embodiments, having a burst strength within a range of about 2,000 psi to about 5,000 psi. The non-metal, polymeric tubular device can be fabricated so as to have distention properties, wherein an orifice or jet port located at a distal end of the polymeric tubular device retains its shape and/or size without suffering swelling that can have a detrimental impact on a fluid jet used to deliver the therapeutic fluid at the treatment site.
  • [0006]
    In one aspect, the present disclosure is directed to a non-metal, polymeric tubular device for delivering a therapeutic fluid to a treatment site within the body wherein the non-metal, polymeric tubular device has a burst strength within a range of about 2,000 psi to about 5,000 psi. The non-metal, polymeric tubular device can be fabricated using suitable high strength polymers including, for example, polyimide, polyetherimide available from General Electric under the trade name UltemŽ and linear aromatic polymers such as PEEK™ available from Victrex plc. In some embodiments, the non-metal, polymeric tubular device can be reinforced through the inclusion of materials including nano-particles, clays and/or glass. In some presently contemplated embodiments, the non-metal, polymeric tubular device can be reinforced with one or more polymers such as, for example, tubes braided with carbon fiber, synthetic para-aramid fiber such as Kevlar available from E.I. du Pont de Nemours and Company or other high-strength polymers. In some embodiments, the non-metal, polymeric tubular device can have a tube length ranging from about 18 to about 72 inches. In some embodiments, the non-metal, polymeric tubular device can include an orifice functioning as a jet nozzle, wherein the non-metal, polymeric tubular device has sufficient strength to avoid distention at the orifice.
  • [0007]
    In another aspect, the present disclosure is directed to a method of delivering a therapeutic fluid comprising providing a non-metal, polymeric tubular device having a burst strength range of about 2,000 psi to about 5,000 psi, delivering the therapeutic fluid through the non-metal, polymeric tubular device and administering the therapeutic fluid to the treatment site with a jet orifice located at a distal end of the non-metal, polymeric tubular device. The method can further comprise positioning the non-metal, polymeric tubular device through an internal lumen within a patient such as a patient's urogenital tract.
  • [0008]
    In yet another aspect of the present disclosure, a therapeutic fluid delivery system can comprise an injector device and a non-metal, polymeric tubular device for delivery a therapeutic fluid to a treatment location within a patient's body. The non-metal, polymeric tubular device can have a burst strength ranging from about 2,000 psi to about 5,000 psi so as to prevent tube failure and to similarly, avoid distention at a jet orifice located at a distal end of the non-metal, polymeric tubular device.
  • [0009]
    The above summary of the various representative embodiments of the invention is not intended to describe each illustrated embodiment or every implementation of the invention. Rather, the embodiments are chosen and described so that others skilled in the art may appreciate and understand the principles and practices of the invention. The figures in the detailed description that follows more particularly exemplify these embodiments.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0010]
    The invention may be more completely understood in consideration of the following detailed description of various embodiments of the invention in connection with the accompanying drawings, in which:
  • [0011]
    FIG. 1 is a perspective view of an embodiment of a therapeutic fluid delivery system for delivering a therapeutic fluid to a treatment location according to the present disclosure.
  • [0012]
    FIG. 2 is a side view of an embodiment of a non-metal, polymeric tubular device according to the present disclosure.
  • [0013]
    FIG. 3 a is a section view of the non-metal, polymeric tubular device of FIG. 2 taken at line 3-3 of FIG. 2.
  • [0014]
    FIG. 3 b is a side view of a portion of an embodiment of a non-metal, polymeric tubular device according to the present disclosure.
  • [0015]
    FIG. 4 is an illustration of the non-metal, polymeric tubular device positioned for delivery of a therapeutic fluid within a patient's urogenital tract.
  • [0016]
    FIG. 5 is a side view of a prior art polymeric tube suffering distention at a jet orifice located at a distal end of the prior art polymeric tube.
  • [0017]
    FIG. 6 is a side view of a non-metal, polymeric tubular device of the present invention delivering a therapeutic fluid through jet injection from a jet orifice at a distal end of the non-metal, polymeric tubular device.
  • [0018]
    While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives.
  • DETAILED DESCRIPTION OF THE DRAWINGS
  • [0019]
    In the following detailed description of the present invention, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, it will be obvious to one skilled in the art that the present invention may be practiced without these specific details. In other instances, well-known methods, procedures, and components have not been described in detail so as to not unnecessarily obscure aspects of the present invention.
  • [0020]
    A needleless fluid delivery system 100 is illustrated generally in FIG. 1. Needleless fluid delivery system 100 can comprise an injector 102 and an applicator lumen 104. Injector 102 can be as simple as manually activated syringe or injector 102 can comprise an automated injector 103 including a user interface 106 and a connector member 108. Connector member can include a surface opening 109 and a therapeutic fluid supply 110. User interface 106 can comprise an input means for selectively delivering a pressurized fluid through the connector member 108. Representative input means can include foot pedal 107, switches, buttons or a touch-screen capable of receiving touch commands as well as displaying system information including a mode of operation as well as operating parameters.
  • [0021]
    As seen in FIGS. 2 and 3 a, the applicator lumen 104 can comprise a non-metal, polymeric tubular device 200 having a proximal attachment end 202 and a distal treatment end 204. Non-metal, polymeric tubular device 200 can have a tube length 206 that corresponds to a type of treatment to be performed within a patient's body. For example, when non-metal, polymeric tubular device 200 is configured to perform a cytoscopic or endoscopic procedure, the tube length 206 can range from about 18 to about 72 inches in length.
  • [0022]
    Non-metal, polymeric tubular device 200 is generally formed so as to have a burst strength of at least about 2,000 psi. In a preferred embodiment, the non-metal, polymeric tubular device is formed to have a burst strength ranging from about 2,000 psi to about 5,000 psi. In one representative embodiment, non-metal, polymeric tubular device 200 is formed of a single high strength polymer such as, for example, a polyimide, polyetherimide available from General Electric under the trade name UltemŽ and linear aromatic polymers such as PEEK™ available from Victrex plc. Alternatively, the non-metal, polymeric tubular device 200 can be formed from a reinforced polymer that is reinforced with reinforcing materials 207 such as, for example, nano-particles, clays or glass. In another embodiment as shown in FIG. 3 b, the non-metal, polymeric tubular device 200 is reinforced with a reinforcing fiber 209 such as, for example, tubes braided with carbon fiber, synthetic para-aramid fiber such as Kevlar available from E.I. du Pont de Nemours and Company or other high-strength polymers braided within non-metal, polymeric tubular device 200. Generally, the non-metal, polymeric tubular device 200 is extruded though other appropriate fabrication methods including molding can be utilized as well.
  • [0023]
    As illustrated in FIG. 4, non-metal, polymeric tubular device 200 can be configured as a cytoscope 300 to deliver therapeutic fluid to a treatment location 302 such as, for example, the urinary bladder 304. Distal treatment end 204 generally accesses the urogenital tract through the urethra 306 wherein the distal treatment end 204 enters the urinary bladder 304. Cytoscope 300 can include a fiber optic scope such that a medical professional can verify the distal treatment end 204 is positioned proximate the treatment location 302.
  • [0024]
    In positioning the non-metal polymeric tubular device 200 at treatment location 302, it will be understood that a medical professional frequently employs a medical imaging system such as, for example, computer axial tomography (CAT), magnetic resonance imaging (MRI), or in the case of treatment of a prostate gland, the preferred imaging means is transrectal ultrasound (TRUS) so as to achieve the desired position of administration orifice 208. Through the use of a medical imaging system, a medical professional can verify that the therapeutic fluid is in fact administered at the treatment location 302.
  • [0025]
    Once the distal treatment end 204, and more specifically, the administration orifice 208 is positioned with respect to the treatment location 302, the injector 102 can be actuated so as to begin delivery of a therapeutic fluid 308 as illustrated in FIG. 6. Generally, injector 102 directs therapeutic fluid 308 through the non-metal, polymeric tubular device 200 at low velocities and high pressures generally between about 2,000 psi to about 5,000 psi. The high pressures supplied by the injector 102 are necessary due to the pressure losses experienced in the relatively, small diameter non-metal, polymeric tubular device 200. As the therapeutic fluid 308 reaches distal treatment end 204, the therapeutic fluid 308 is rapidly accelerated through the administration orifice 208 to form a fluid jet 310. Using fluid jet 310, therapeutic fluid 308 can be controllably dispensed directly at the treatment location 302 so as to reduce the potential for exposure to other non-desired areas. As the fluid jet 310 moves away from the administration orifice 208, the pressure of fluid jet 310 is rapidly lost.
  • [0026]
    By using non-metal, polymeric tubular device 200, problems associated with using conventional polymeric tubing can be avoided. With reference to FIG. 5, conventional polymeric tubing 400 can suffer a variety of failure modes including, for example, distention or swelling of the conventional polymeric tubing 400 at an administration orifice 402. When distention occurs, the changing dimensional characteristics of the administration orifice cause uncontrolled variations in the characteristics of a fluid jet 404 as well as potential failure and rupture of the conventional polymeric tubing 400.
  • [0027]
    While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives.
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US20130138082 *23 Jan 201330 May 2013Amr SalahiehIntravascular Tissue Disruption
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Classifications
U.S. Classification604/517
International ClassificationA61M31/00
Cooperative ClassificationA61M39/08, A61M5/30, A61M25/0075, A61M25/005, A61M5/3007, A61B1/307
European ClassificationA61M25/00T20A, A61M39/08, A61M25/00S2
Legal Events
DateCodeEventDescription
2 Feb 2010ASAssignment
Owner name: AMS RESEARCH CORPORATION,MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CRANK, JUSTIN M.;REEL/FRAME:023885/0767
Effective date: 20071204