US20090204109A1 - Eye-Safe Dermatologic Treatment Apparatus and Method - Google Patents
Eye-Safe Dermatologic Treatment Apparatus and Method Download PDFInfo
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- US20090204109A1 US20090204109A1 US12/271,819 US27181908A US2009204109A1 US 20090204109 A1 US20090204109 A1 US 20090204109A1 US 27181908 A US27181908 A US 27181908A US 2009204109 A1 US2009204109 A1 US 2009204109A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A61B2017/00061—Light spectrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A61B2017/00066—Light intensity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00681—Aspects not otherwise provided for
- A61B2017/00734—Aspects not otherwise provided for battery operated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
- A61B2090/065—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
Definitions
- the invention relates to a dermatologic treatment apparatus and method, and particularly to an apparatus that is light-based, yet eye-safe.
- the radiant exposure applied to the skin (often referred to as “fluence”, expressed in joules per square centimeter) by this class of devices is typically in the 10-40 J/cm 2 range at a wavelength of nominally 800 nanometers. It was initially believed that pulse durations in the 5-30 ms range are optimum; however, subsequent studies showed that longer pulses (up to at least several hundred milliseconds) can quite effectively achieve hair-regrowth inhibition, and can also reduce epidermal heating for a given fluence when a heat conduction path is provided (e.g., by incorporating an output window made of sapphire in contact with the skin).
- the high efficiency and small size of the semiconductor diode lasers utilized in these devices generally permit the manufacture of compact systems (typically 1-3 cubic feet in volume) and simple 115 VAC operation. However, the systems typically weigh at least 25-100 pounds and sell in the range of $40,000 to $90,000. A much lower cost, truly portable device would make this popular procedure much more widely available.
- Lasers and intense light sources have gained increasing acceptance among dermatologists for effective treatment of a wide range of applications, such as hair-regrowth inhibition and permanent hair reduction, removal of tattoos, treatment of birthmarks, and facial resurfacing. It is well understood by medical professionals, however, that such light sources are capable of serious eye damage or blindness.
- the fluence on the skin typically exceeds 1 J/cm 2 .
- the safety of a light-based dermatologic device can be increased by incorporation of a contact sensor that enables device operation only when in the sensor is in contact with a surface, such as a person's skin.
- the light source laser, light-emitting diode, flashlamp, etc.
- the light source can be placed within a housing having a single open end through which the light propagates; a contact sensor at this open end can enable operation of the device only if the housing is placed up against a contacted surface. In this manner light can only propagate into or through the surface against which the device is placed.
- any type of sensor added to increase eye safety adds complexity and may, of course, fail.
- the ideal dermatologic treatment device and method would not depend on electronic circuitry or user compliance with safety eyewear for safe use.
- the '49633 published application addresses the eye-safety issue by providing a diffusing unit.
- the device includes a substantially non-portable laser floor unit and an extensible handpiece connected by a long beam delivery light guide.
- other safety issues exist for this device.
- a home use, self-care setting may not be equipped to handle the electrical safety issues of a device that draws high current from a wall outlet.
- the invention described in the application addresses enhanced eye safety from a collimated laser beam, convergent laser beam, concentrated multiple laser beams or a fiber guided beam, and from monochromatic sources.
- divergent light sources can be rendered eye safe substantially more easily, as described below in accordance with the present invention.
- the '029 and '020 patents describe devices that provide fluences over 100 J/cm 2 . These fluences are generally too large to be eye-safe and epidermis-safe in use in a self-care setting. Such output fluences are likely to give rise to fluences at the cornea potentially above the Maximum Permissible Exposure (MPE), described in more detail below, and/or may likely cause burning of the epidermal region of the treated skin. Moreover, such fluence levels are not efficiently produced in a self-contained apparatus, such as a hand-held and battery-powered device as is desired for self-care and home use in accordance with an embodiment of the present invention.
- MPE Maximum Permissible Exposure
- the current state of the art of light-based epilation is well described by considering the two general types of devices on the market.
- One market segment encompasses devices designed and sold to physicians.
- Representative products include the LightSheer diode laser system now manufactured by Lumenis Ltd., the SLP-1000 fiber-coupled diode laser by Palomar Medical Technologies Inc., the Quantum flash lamp system manufactured by Lumenis Ltd., and the CoolGlide Excel YAG laser by Altus Inc.
- the physician devices are characterized by (a) established efficacy as confirmed by FDA clearance, (b) practical coverage rate, (c) high cost, and (d) relatively large size having a physical design where a handpiece is attached to a console, and (e) output fluences representing a severe eye hazard.
- These devices provide efficacious and practical light-based epilation and generally involve a peak optical power greater than 50 W, output fluence of greater than 10 J/cm 2 , spot size greater than 0.5 cm 2 , and a coverage rate greater than 10 cm 2 /min. Examples of these office-based devices are described in the patent literature cited above, and further examples may be found in other references cited herein.
- the other market segment comprises the limited number of consumer light-based epilation devices. It is believed that there are no personal light-based epilators currently on the market in the United States. At present, the most developed market for consumer light-based devices is Asia, and, in particular, Japan, where there are tens of products on the market. The devices by Ya-Man Ltd. of Tokyo are typical of the state of the art for these products in Japan.
- consumer devices are characterized by (a) greatly reduced or no efficacy due to low peak power (.about.1 W or less) and small spot size (.about.0.1 cm 2 or less), (b) slow coverage rate due to the small spot size and involving the targeting of individual hair follicles, (c) low cost, (d) relatively small size having a physical design where a handpiece is attached to a console or corded to a wall power supply, and (e) output fluences exceeding eye safety limits.
- Discrete laser diodes are limited in peak power to roughly one watt. While this low power may be adequate for treating individual hairs (such as the Ya-Man device manufactured in Japan), treatment of multiple hairs at a time for rapid treatment of extended areas requires peak optical powers of roughly 25 watts or more.
- diode laser bars rather than discrete diode laser devices, are incorporated into the diode-based office products named above. The success of these hair-regrowth inhibition systems incorporating laser diode bars, used by doctors and nurses in an office setting, has fueled interest in the development of home-use devices. The inconvenience of multiple visits to the doctor's office has also increased interest in devices that can be used safely and privately at home.
- such a consumer device would be compact, inexpensive and battery powered, while incorporating proven laser diode bar technology.
- the U.S. Pat. No. 6,533,775 patent describes a mechanical hair removal device, and not a light-based hair-regrowth-inhibition apparatus.
- the device described in the '775 patent includes a light source that reacts chemically with skin cream applied to the surface in order to reduce the onset time.
- the light produced by the mechanical hair removal device is not for effecting thermal damage of hair follicles to inhibit regrowth.
- the light is not designed to penetrate through the cream to create any thermal injury to targets within the dermis.
- the '97587 application describes a device with variable current control. This device is not designed for medical applications.
- the reference also does not provide any output fluences, wavelengths or pulse lengths that might by chance render the fluence at the eye of a person to be under the MPE. There would simply have to be many modifications made to this device to render it eye-safe for home use and to render it efficacious for dermatologic treatment for hair-regrowth inhibition.
- the '4499 application describes a device that is described as being designed to inhibit hair regrowth.
- the '4499 application refers to its procedure as bio-stimulation to produce bio-inhibition, and in any case, it is non-thermal. This is a wholly separate field from hair-regrowth-inhibiting devices that operate by causing thermal damage to hair follicles.
- the '4499 reference uses much lower fluences (or intensities) than would be efficacious for causing thermal damage to a hair follicle to produce hair-regrowth inhibition.
- a dermatologic treatment apparatus includes a one or more housings with at least one housing configured for manipulation in a dermatologic treatment procedure, a light source within at least one of the housings, and an electrical circuit.
- the circuit energizes the light source to produce output light pulses.
- a housing contains a light path from the light source to an aperture through which eye-safe light pulses are propagated out of at least one of the housings having properties sufficient for providing efficacious treatment.
- An optical diffuser is disposed along the light path to reduce the integrated radiance to an eye-safe level.
- the apparatus produces an output fluence not less than 4 J/cm 2 .
- the dermatologic apparatus produces a fluence on the skin surface that is sufficient for efficacious treatment and has an integrated radiance insufficient to cause eye damage.
- the light source is a divergent light source.
- the light source has a divergence that is greater than 1 degree, and is preferably greater than 6 degrees.
- the optical diffuser may be transmissive or reflective.
- a transmissive diffuser may include a bulk scattering diffuser medium such as opal glass, PTFE, thin Spectralon, or combinations thereof.
- the transmissive diffuser may also include a diffusive surface that is refractive or diffractive, or both, and may include a random surface such as ground glass, sandblasted glass or plastic, etched glass or plastic, or molded materials produced by a randomly textured mold, or combinations thereof.
- the transmissive diffuser may also include a patterned surface such as a holographic or Fresnel pattern.
- a mixer may be disposed along the light path for distributing light more uniformly at the aperture.
- the principal optical axis of the light emitted by the source striking the diffuser is, in one embodiment, not parallel to the normal of the surface of the diffuser.
- the majority of the energy of a light pulse is contained within the spectral band of 700 nm to 1100 nm.
- the light pulses are emitted at a pulse repetition frequency between 0.1 Hz and 2 Hz, have pulse durations between 10 milliseconds and 1 second, have a peak power between 10 watts and 120 watts, and produce a spot size between 0.25 cm 2 and 5 cm 2 .
- the dermatologic treatment procedure may involve photorejuvenation.
- the light source is preferably a flashlamp light source. At least a majority of the energy of the output light pulses emitted by the light source is between 500 nm and 1100 nm.
- the dermatologic treatment apparatus may be configured for performing at least temporary hair-regrowth inhibition, for treating acne, for treating benign pigmented lesions, for vascular treatment, and/or for skin texture or wrinkle treatment, or both.
- the light pulses are optically diffused along the light path to reduce the integrated radiance to an eye-safe level. Then, the device is manipulated in a skin treatment procedure that produces a fluence on the skin that is sufficient for efficacious treatment and yet has an integrated radiance insufficient to cause eye damage.
- FIG. 1 schematically illustrates a dermatologic treatment apparatus in accordance with a first embodiment that is self-contained and battery-powered.
- FIG. 2B schematically illustrates a dermatologic treatment apparatus in accordance with a third embodiment in contact with a person's skin, that is eye-safe and that incorporates a reflective diffuser.
- FIGS. 3A and 3B schematically illustrate an optical diffuser in accordance with the second embodiment.
- FIG. 3C schematically illustrates an optical diffuser in accordance with the third embodiment.
- FIG. 3D schematically illustrates yet another type of optical diffuser that has a spatially uniform output.
- FIG. 4 schematically illustrates the divergence of a laser beam transmitted through a biconcave lens.
- FIG. 5 schematically illustrates a hair-regrowth-inhibiting apparatus in accordance with the second embodiment.
- FIG. 6 schematically illustrates a front perspective view of a self-contained housing of a hair-regrowth-inhibiting apparatus in accordance with a preferred embodiment.
- FIG. 7 schematically illustrates a rear perspective view of the self-contained housing of the hair-regrowth-inhibiting apparatus of FIG. 6 .
- FIG. 8 schematically illustrates indicator lights of the hair-regrowth-inhibiting apparatus of FIGS. 6-7 .
- FIG. 9 schematically illustrates a perspective view of an AlGaAs laser diode bar.
- FIG. 10 schematically illustrates a cross-sectional view of a hair-regrowth-inhibiting apparatus in accordance with the second embodiment.
- FIG. 11 schematically illustrates components of an electrical circuit in accordance with a preferred embodiment.
- FIG. 12 schematically illustrate components of an electrical circuit for powering a laser diode light source with batteries through a FET-based switch in accordance with a preferred embodiment.
- a device and method are described in a first embodiment that enable light-based dermatologic treatment with a self-contained and handheld device.
- the device embodies an advantageous combination of a battery-powered electrical circuit design, a self-contained housing mechanical design, and a light source and optical design, that enables efficacious and practical dermatologic treatment in a cordless and handheld manner.
- the light source may be, for example, one or more semiconductor laser diode bars that generate pulses of infrared light.
- the light source passes through the epidermis and is absorbed by melanin in the hair shaft and follicle. The resulting brief temperature rise of the follicle temporarily disables it, delaying the regrowth of hair.
- the device can be pulsed at a repetition rate of up to 0.5 Hz.
- Effective dermatologic treatment e.g., hair-regrowth inhibition
- This avoids the need for very high peak laser powers; for example, to produce 20 J/cm 2 in 350 ms with a 9 mm by 9 mm output area requires a optical peak power of only 46 watts.
- the modest peak power requirement reduces the electrical pulsed power requirement, and thereby permits battery operation.
- thermo-electric (TE) modules and advanced nickel-metal-hydride battery technology such a device has been invented that may be entirely handheld, with the aforementioned parameters in a preferred embodiment.
- FIG. 1 A device in accordance with a preferred first embodiment is illustrated schematically in FIG. 1 .
- the elements shown are light source 10 , mixer 12 , output window 14 , heat-removal element 16 , electrical battery 18 , and housing 20 .
- Not shown but involved in the operation of the device are other mechanical, electrical, and optical elements (such as a trigger, drive and control circuitry, sensors, and indicators) such as may be described in more detail below and/or as may be understood by those skilled in the art. That is, FIG. 1 is intended merely to serve to introduce the device of a preferred first embodiment to be described in more detail below.
- the user charges the electrical battery 18 (by placing the device in a charging station, for example, that will provide electrical charge from a wall outlet). Once charged, the user presses an output window 14 or aperture 14 against the surface of the skin to be treated.
- the aperture or window 14 in contact with the skin is preferably made of sapphire, because of its relatively high thermal conductivity.
- the output aperture or window 14 may, however, be only an opening or aperture such that the window component 14 that contacts the person's skin may be a frame of the opening.
- the heat-removal element 16 draws waste heat from light source 10 and may draw heat as well from the skin by conduction through window 14 and mixer 12 .
- the preferred device operates at a fixed, mid-range output fluence setting of nominally 20 J/cm 2 and a fixed, mid-range pulse duration of nominally 300-350 ms.
- the output fluence would be continuously or discretely adjustable. Details of the electrical circuit design are provided below.
- the output window 420 is indicated along with the vent louvers 440 , as well as an on-off button 460 and indicator lights 470 .
- the indicator lights 470 are illustrated in more detail in FIG. 8 .
- a battery charge indicator 472 , an on/off indicator 474 and a ready indicator 476 are provided examples.
- the primary elements of the apparatus will preferably have a volume less than approximately 2000 cm 3 , and more preferably less than approximately 1000 cm 3 , and a weight less than approximately one kilogram. Even more preferably, the apparatus may have a volume less than 700 cm 3 and a weight less than 700 grams. In this way, the apparatus can be gripped and firmly controlled in a self-care procedure within a user's hand without providing stress in the user's grip and without causing excessive fatigue during use. As illustrated in FIGS. 6-7 , the apparatus has a volume of 400 cm 3 and a weight of 500 g in a cordless, self-contained device.
- cordless it is meant to refer to a unit that is battery-powered and not electrically plugged into an external outlet or power source during use.
- self-contained it is meant that the unit is not physically connected to a base unit or other such unit and is free to be manipulated without attached wires or couplings.
- a self-contained housing 410 such as that illustrated in FIGS. 6-7 has the light source and batteries contained within it, such that the housing is not attached to any electrical cable or light guide cable that protrudes out of the housing 410 .
- a wireless control, or other wireless coupling, or the charging base 450 cannot be included components of a unit that includes the preferred self-contained housing 410 illustrated in FIGS. 6-7 ; however in use, the housing 410 is free of externally protruding physical couplings such as control wires, optical cables and power cords.
- the handheld device of the preferred embodiment is highly efficient, self-contained and user friendly. Furthermore, the output parameters of the device establish that it is efficacious and practical in use.
- Charging the apparatus involves its placement into a charging base 450 shown in FIG. 6 generally overnight prior to use. Charging of the device is easily done by plugging the power cord into a suitable AC outlet and placing the device into the charging stand 450 . Following use, the unit should be returned to the charger 450 , so that it will be fully charged for the next use. The unit may be left in the charger 450 for extended periods of time without harm to the unit.
- the left indicator light 472 ( FIGS. 7-8 ) flashes green. When the battery is fully charged, this light will cease flashing and remain green.
- Preparing the skin for maximum comfort during use involves shaving the area to be treated prior to treatment, and then wiping with a cool, damp cloth. Because the unit relies on absorption of light by the hair shaft under the skin, the hair should not have been previously removed by plucking or waxing. If either of these methods were performed recently on the area to be treated, treatment should be postponed until hairs are once again visible.
- Performing the treatment after the unit has been fully charged, involves turning on the unit by pressing and releasing the ON-OFF button 460 shown in FIG. 7 .
- the center indicator light 474 shown in FIG. 8 will illuminate.
- the right indicator light 476 may flash, indicating that the unit is approaching the “ready” state.
- the right indicator light 476 when steadily green, indicates that the device is ready and will emit a light pulse when either of the two trigger buttons 430 is depressed (provided that the output window 420 is in contact with skin).
- Two triggers 430 are provided to permit comfortable use of the device in either hand.
- the output window 420 is placed firmly against the shaved skin area to be treated, and either trigger 430 pressed and released.
- a beep will be preferably heard when the laser pulse is completed.
- a beep and/or other tone or sensory indication is preferably heard when good contact is made within the skin indicating that the contact sensors around the window 420 are in contact with the skin and will permit the pulse to be propagated out of the housing 410 . Accordingly, the self-care user will know that the unit will not generate a pulse until good contact is established and the tone is heard.
- a beep and/or other tone or sensory indication will be heard if after making good contact with the user's skin, the output window 420 is moved away from good contact.
- This indication is to inform the user that a pulse will not be permitted to be propagated from the housing 410 until good contact is re-established.
- the output window 420 is moved to an adjacent area, allowing for approximately fifty-percent overlap. That is, the tip should be moved a distance about one-half the width of the area contacting the skin. It is not necessary to hold the trigger down throughout the pulse. It is, however, important to maintain full contact between the skin and the output window 420 for the entire duration of the laser pulse. If the output window 420 is lifted from the skin prior to completion of the laser pulse, a distinct tone is sounded to alert the user, and the area should be re-treated with an additional pulse.
- the preferred maximum repetition rate of the unit is one pulse every two seconds, and generally between one pulse every second and one pulse every four seconds. Thus there may be a few-seconds delay before the next beep is heard.
- a dermatologic treatment device and method incorporate an optical diffuser, described in detail below, to greatly enhance the eye safety of the device while minimally affecting efficacy.
- an optical diffuser to increase the divergence and to reduce the spatial coherence of the light emitted from the device allows the apparatus to be classified as a Class I Laser Device under the guidelines of the U.S. Food and Drug Administration Center for Devices and Radiological Health. This permits the use of the apparatus without having to wear laser safety glasses or goggles, and most importantly, eliminates the risk of eye injury if other safety means such as the contact sensor described above should fail.
- dermatologic treatment does not generally require a highly directed beam.
- the light is confined in some manner within a handpiece or applicator prior to its entering the skin surface, there is very little value in requiring the light to strike the skin at normal incidence (i.e., light rays oriented roughly perpendicular to the skin surface).
- the skin is a highly scattering medium, and any light rays entering the skin at normal incidence are scattered by epidermal skin cells very near the surface and thus are redirected into all angles.
- the incorporation of a diffuser accomplishes this spreading of the light rays prior to entering the skin, which has little impact on efficacy but greatly enhances eye safety.
- the devices described in the second and third embodiments below can readily accommodate the essential elements of the first embodiment. That is, the eye-safe devices described in the embodiments below could be realized in a self-contained, battery-powered device. Alternatively, the devices described below could be corded to operate from a conventional wall outlet during use. It is also noted that the method of use of the devices described in the second and third embodiments is essentially the same as that described in the first embodiment.
- a light source 140 Contained within the source chamber 130 is a light source 140 that emits pulses having many advantageous features.
- Light source 140 may be, for example, a laser diode assembly for treatment of a dermatological condition, and preferably includes one or two laser diode bars.
- the diffusing material 120 is placed over an aperture in source chamber 130 .
- Light source 140 preferably does, but need not, uniformly illuminate diffuser 120 .
- the diffuser 120 is designed to increase the divergence of the light emitted from light source 140 , and to reduce the spatial coherence of the light source.
- Diffuser 120 may be made of a material that scatters light traveling through it, such as an opalized glass substrate. Details regarding appropriate optical diffuser designs and materials are contained in a subsequent section describing component details.
- the inner walls of the source chamber 130 would be coated and/or otherwise constructed of a material that is non-absorbing at the therapeutic wavelengths emitted by source 140 .
- a source chamber that is not substantially non-absorbing would also be acceptable; however, a more intense light source 140 would be involved for the same power delivered to the skin.
- the requirement for additional power is not desirable, particularly in a cordless, hand-held, self-care device because energy efficiency is at a premium.
- the spatial uniformity of the light may be increased through the use of a mixing chamber 110 which may be simply a hollow tube with substantially non-absorbing side walls through which the light would propagate prior to leaving the apparatus through output window 100 . If the spatial uniformity of the light at the diffuser is adequate for the desired treatment, the mixer can be omitted, so that the diffuser 120 may even be in contact with the skin and serve as the output window. Alternatively, the diffuser 120 may be located at the position shown in FIG. 2A even if it is determined that sufficient uniformity may be achieved without the function of the mixing chamber 110 . It is desired, however, that the diffuser 120 not be placed so close to the light source 140 that substantial non-uniformity results from the light not having sufficiently diverged from the light source before impinging upon the diffuser 120 .
- FIG. 2B schematically illustrates a dermatologic device, such as a light-based hair-regrowth-inhibition device, incorporating a reflective diffuser in accordance with the third embodiment of the invention.
- the term reflective diffuser is intended to describe an element incorporated into a light path having a first or input surface which the light initially strikes; however, in contrast to a transmissive diffuser, this first surface also serves as the output surface from which light propagates from the diffuser.
- the term “reflective” is used in this context to include remitted light. That is, the diffuser may scatter or refract light as well.
- a light-based hair-regrowth-inhibition device is illustrated in contact with skin 155 that incorporates the use of a diffusing material 125 which diffuses light from source or sources 145 before the light leaves the apparatus though output window (or simply an open aperture) 105 .
- a diffusing material 125 which diffuses light from source or sources 145 before the light leaves the apparatus though output window (or simply an open aperture) 105 .
- Contained within the chamber 115 is a light source or sources 145 that emit pulses having many advantageous features.
- Light source or sources 145 may be, for example, laser diode bars for treatment of a dermatological condition such as unwanted hair.
- the diffusing material 125 is placed within chamber 115 in a position generally opposite the skin, as shown.
- Light source or sources 145 preferably does, but need not, uniformly illuminate diffuser 125 .
- the diffuser 125 is designed to increase the divergence of the light emitted from light source or sources 145 and to reduce the spatial coherence of the light source or sources.
- Diffuser 125 may be constructed of a highly scattering material such as PTFE, e.g., Teflon. Details regarding appropriate optical diffuser designs and materials are contained in a subsequent section describing component details.
- the inner walls of the chamber 115 would be coated and/or otherwise constructed of a material that is non-absorbing at the therapeutic wavelengths emitted by source or sources 145 .
- FIG. 2B illustrates the concept of a reflective diffuser in an embodiment wherein light from the source or sources 145 is initially directed away from the skin 155 , prior to striking diffuser 125 .
- the device in FIG. 2B could be alternatively constructed wherein light from source or sources 145 initially propagates in a direction toward the skin; but, prior to striking the skin, such light is redirected by a mirror or mirrors back toward the diffuser 125 .
- the light source 10 is preferably two diode laser bars at a nominal wavelength of approximately 800 nm.
- Operating specifications may be, for example, 20 J/cm 2 output fluence, 350 ms pulse duration, 0.8 cm 2 spot size (output aperture), and 0.5 Hz pulse repetition rate. These parameters correspond to an optical peak power of 46 W and a duty cycle of about 18%; the resulting average optical power is thus about 8 W.
- Diode bars operating at these parameters are about 35-40% efficient; thus the average electrical power into the light source is about 23 W (8 W of emitted average optical power and about 15 W of waste heat).
- the volume and weight of the light source is about 1 cm 3 and 10 g.
- Alternative embodiments for the light source include use of one diode laser bar rather than two, use of more than two diode laser bars, use of light emitting diodes (LED's), and use of a flash lamp (also known as a flash tube) or arc lamp.
- LED's light emitting diodes
- flash lamp also known as a flash tube or arc lamp.
- a skin contact sensor is preferably incorporated into the tip of the preferred dermatologic treatment apparatus.
- the sensor may include a ring of very small “membrane switches” located around the circumference of the preferred sapphire window. The signals from the membrane switches prevent firing of the device unless it is in substantial contact with a contacted surface such as skin.
- the trigger may be eliminated, and the closing of one or more membrane switches may activate one or more light pulses.
- audible or other sensory indications are preferably provided when good contact is made, and when the output window is displaced from a good contact position on the user's skin such that firing is disabled until good contact is again established.
- An audible or other sensory indication is also preferably provided at the end of a pulse indication to provide feedback to the user that the apparatus may be moved to another location before the next pulse.
- the charging base may be similar to those currently produced for use with electric toothbrushes, shavers, phones, etc.
- the base is connected to a standard AC outlet, and is capable of recharging the batteries overnight.
- the apparatus in the second or third embodiment may also be corded to operate from a standard wall outlet during use, eliminating the need for a charging base.
- the mixer 12 serves to (a) to mix the light emitted from the diode lasers to produce a uniform beam profile at the output window 14 , (b) to provide a low thermal resistance path between the output window 14 and the heat-removal element 16 , and (c) to minimize thermal loads on the device that are due to light absorption from back-reflected or back-scattered light.
- the mixer 12 comprises a hollow chamber where the wall material is either copper or aluminum.
- the walls are either the polished substrate or coated to achieve high reflectivity to 800 nm light.
- the length of the mixer is designed to provide good spatial uniformity of light on a 1.times.1 cm output window from two diode bars spaced 6 mm apart.
- the wall thickness of the mixer is designed to provide good thermal conductivity between the output window 14 and heat removal element 16 .
- a wall thickness of about 2 mm is required to conduct about 8 W of average power to a thermal source 2 cm away with a 5 degree C. temperature rise.
- the volume and weight of the mixer is about 4 cm 3 and 20 g.
- the thermal load on the mixer due to light absorption is less than 1 W.
- An alternative embodiment of the mixer 12 might include various shapes and may comprise multiple elements to achieve the thermal link between the output window and the heat removal element and to achieve light mixing and low light absorption.
- the cross-sectional shape may be any of a variety of shapes (such as circular or rectangular) and may vary along the length of the mixer. Because the skin, or the diffuser, or the walls of the mixer may remit light in a direction away from the skin, the mixer may comprise not only low-absorbing side walls, but also a low-absorbing surface opposite the output aperture. Such low-absorbing surface may contain one or more openings through which light from the light source passes, or may simply constitute the surface adjacent to the light source.
- the mixer may consist of an inner mixer, such as a sheet of polished metal, for the purpose of reflecting light from the light source toward the output window 14 ; and a thicker metal outer surface, such as a copper or aluminum barrel, to conduct heat from output window 14 to heat-removal element 16 .
- the inner mixer may alternatively be fabricated from a solid transparent material such as glass or acrylic. In this case the light from the light source would be reflected toward the output window 14 by total internal reflection within the glass or acrylic.
- diffuser refers throughout this patent application not only to conventional, commonly known elements such as the “optical disk diffuser” of the flashed opal type (e.g., Oriel Instruments Model 48010, Stratford, Conn.) but more generally to any element that, when incorporated into a light-emitting device having a given radiant exposure or fluence, greatly reduces the integrated radiance (“brightness”) of the device.
- a diffuser generally increases the divergence and reduces the spatial coherence of light incident upon it.
- diffuser 120 may be made of a material that scatters light as it travels through it such the abovementioned optical disk diffuser from Oriel.
- diffuser 120 may be a transparent substrate whose surface has been roughened so as to scatter the incident light through refraction.
- Diffuser 120 may be a bulk scattering diffuser, made for example from opal glass, PTFE, a thin (e.g. 0.5 mm) sheet of Spectralon, or combinations thereof.
- the diffuser 120 may alternatively have a refractive or diffractive surface or body; or have a diffusing surface comprising random surface irregularities.
- diffusers may be made of ground glass, sandblasted glass or plastic, or molded materials produced by a randomly textured mold, or combinations thereof.
- diffuser 120 may have a patterned surface or body, for example with a holographic or Fresnel pattern.
- the reflective diffuser 125 as shown in FIG. 2B may be constructed of a highly scattering material such as PTFE, or a commercial material such as Spectralon (available from LabSphere, Inc.).
- diffuser 125 may comprise a scattering material such as Duraflect (also available from LabSphere, Inc.) applied to the surface of the chamber 115 opposite the skin 155 .
- diffuser 125 may be fabricated simply by roughening the surface of chamber 115 opposite the skin 155 ; however, the preferred embodiment would incorporate an actual diffusing material such as Spectralon, or an applied surface coating such as Duraflect, due to the low absorption of these materials.
- diffuser 125 may be made of a material that scatters light as it travels through it such as an opalized glass substrate, e.g., part #48010 manufactured by Spectra-Physics (Oriel), and then backed by a highly reflective mirror; in this way a transmissive diffuser material can be made to serve as a reflective diffuser.
- an opalized glass substrate e.g., part #48010 manufactured by Spectra-Physics (Oriel)
- a transmissive diffuser material can be made to serve as a reflective diffuser.
- FIG. 3A illustrates an example of a diffuser 120 including transparent screens of the fine-structure or lenticular types.
- FIG. 3A illustrates transmissive sheets having molded or machined refractive or diffractive elements.
- the diffuser 120 may also include zones of concentric microgrooves, as illustrated at FIG. 3B .
- the diffuser 125 of FIG. 2B may include merely roughened interior surfaces of a passageway through which light is scattered prior to exiting the device, such as illustrated at FIG. 3C , discussed in reference to FIG. 3E in more detail below.
- Yet another means of achieving very low integrated radiance for a given output fluence from a device in accordance with embodiments of the invention includes a small light source approximating a “point source” projecting into a mixer having mirrored walls such as that illustrated at FIG. 3D .
- FIG. 3E shows an embodiment of the current invention in contact with skin 250 that incorporates the use of the diffusing surface 220 of FIG. 3C which the light strikes before leaving the apparatus though output window 200 .
- light source 240 is housed within source chamber 230 .
- a diffusing surface 220 is positioned relative to source 240 such that the light strikes surface 220 prior to leaving the device.
- Diffusing surface 220 may be merely a roughened surface such as sand-blasted aluminum designed to diffuse the light, or diffusing surface 220 may be a surface coated with a bulk diffuser such as an opalized material used in part #48010 manufactured by Spectra-Physics (Oriel).
- Surface 220 need not coat the entire inner wall of source chamber 230 but only a sufficient portion to achieve a desired level of beam divergence and reduced spatial coherence.
- a preferred embodiment would use a material for surface 220 that is substantially non-absorbing at the therapeutic wavelengths emitted by source 240 .
- the output window 14 is preferably a transparent, high heat capacity and high thermal diffusivity material, such as sapphire, with a low thermal resistance connection to the mixer 12 .
- a thickness of 5 mm provides acceptable heat sinking capability for a 1.times.1 cm sapphire window.
- the volume and weight of the output window 14 is about 0.5 cm 3 and 2 g.
- the thermal load on the output window is about 8-9 W of average power.
- the heat-removal element 16 could be a thermal battery made of a high heat-capacity single-phase material, such as copper, water, or aluminum, or could be any of a variety of phase-change materials such as salt hydrates and paraffin waxes, which can provide 5-10 times greater thermal energy density and thus provide for a more compact thermal battery.
- An embodiment with the thermal battery material TEAP/Climator ClimSel 24 can store 210 J/cm 3 and 144 kJ/kg over a 10 degree C. working range. Thus, for a 10 minute treatment at 23 W of average heat load the thermal battery would be about 70 cm 3 and 100 g.
- thermoelectric-based heat exchanger examples include a thermoelectric-based heat exchanger.
- the heat exchanger would have a cold-side heat sink thermally connected to the rest of the device, a thermoelectric module, and a hot-side heat sink thermally connected to the environment.
- a fan to provide forced convection may be part of this heat exchanger.
- FIG. 10 A semi-schematic cross-sectional drawing of an apparatus in accordance with a preferred second embodiment is shown in FIG. 10 .
- the laser head of the device containing preferably two AlGaAs laser diode bars mounted on a fan-cooled, finned heat sink.
- the laser light propagates through a square tube having a cross-section of 9 mm by 9 mm, through an opal-glass diffuser and sapphire window pair 626 .
- the sapphire window which is in contact with the skin during treatment, is held near room temperature by small thermoelectric modules mounted on either side of the diode bars.
- a typical diode laser bar 500 including multiple diode emitters 510 such as that illustrated at FIG. 9 (and such as may be manufactured by Spectra-Physics, Inc., of Mountain View, Calif., or Coherent, Inc., of Santa Clara, Calif.), has a continuous optical power output of 20-40 watts, and a maximum peak power output approaching 100 watts. For this reason, a hair-regrowth-inhibition device with an output optical peak power of over 25 W can be designed with only one or two bars 500 , rather than 25 or more discrete laser diodes.
- Each laser diode bar 500 has many individual emitters 510 preferably fabricated on a monolithic structure, and requires roughly 40 amperes of current at a voltage of slightly under 2.0 volts to produce 30 watts of optical peak power output for more than 50 milliseconds.
- Device housing 610 contains battery pack 710 consisting of, for example, six nickel-cadmium or nickel-metal-hydride 1.2 V “C size” batteries (e.g., Panasonic part no. P-170SCW, or HHR300SCP). Housing 610 also encloses circuit board 614 containing the control electronics, described in detail below. Electrical power from the battery pack 710 is conditioned and controlled by electronics on circuit board 614 , and current of nominally 40 A is conducted through wires (not shown) to laser diode bars 720 mounted on heat sink 618 (e.g., laser diode bar packages, part no. ASM06C040W080810B80, Cutting Edge Optronics).
- battery pack 710 consisting of, for example, six nickel-cadmium or nickel-metal-hydride 1.2 V “C size” batteries (e.g., Panasonic part no. P-170SCW, or HHR300SCP). Housing 610 also encloses circuit board 614 containing the control electronics, described in detail below. Electrical
- Heat sink 618 is attached to finned heat sink 620 (e.g., part no. HX8-101, Melcor, Trenton, N.J.), and cooled by fan 622 (e.g., part no. FAN-101 from Melcor) which is also powered by the battery pack 710 .
- Heat sink 618 is preferably a good thermal conductor and an electrical insulator.
- the material BeO is preferably used for the heat sink 618 .
- the finned heat sink 620 may comprise a block of aluminum or copper or other material of high thermal conductivity.
- the finned heat sink 620 exchanges heat with the air which is circulated by fan 622 .
- Laser light from laser diode bars 720 passes through mixer 624 (for example, a hollow tube of square cross-section having highly reflective walls, such as gold-plated aluminum).
- Diffuser/window 626 is prevented from overheating by allowing excess heat from diffuser/window 626 to be conducted through mixer 624 to the cold side of thermoelectric (TE) cooling modules 630 (e.g., Melcor part no. CP 0.8-31-06L).
- TE modules 630 are in turn cooled by placement of their hot side against heat sink 620 .
- TE modules 630 are preferably solid-state devices that pump heat from mixer 624 to the heat sink 620 .
- the principal optical axis of the laser diode bars may be aligned with the principal optical axis of the mixer and parallel to the normal to the surface of the diffuser/window 626 , as shown in FIG. 10 .
- the principal optical axis of the light emitted from the laser diode bars is not substantially parallel to the normal of the surface of the diffuser. This may be accomplished by tilting the principal optical axis of the laser diode bars so that they are not parallel to the normal of the surface of the output window; or by mounting the diode bars so that their principal optical axis is parallel to the normal of the surface of the diffuser, but the light emitted from such bars strikes the diffuser at a different angle through the use of a mirror or mirrors.
- the angle is preferably around 45 degrees. This embodiment permits the light generated by the laser diode bars 720 to already be spreading outward from the forward direction prior to striking the diffuser/window 626 , resulting in an even more diffused and eye-safe beam propagated from the housing 410 .
- the apparatus comprises a hand-held treatment device for dermatologic use, one or more batteries, one or more laser diode bars, and an electronic control circuit.
- the apparatus enables, for the first time, effective home hair-regrowth inhibition, in a device significantly above the 1 W optical output level that is compact, affordable (less than $1,000) and is free of cords and/or other connections to an electrical outlet.
- the device incorporates a small number of batteries (preferably three to six), an efficient circuit design that effectively draws 40 amperes or more from the batteries, and typically contains one or two laser diode bars producing a combined optical peak power output of 10-120 W, or more preferably 30-60 W, at 800 nm.
- the consumer can inhibit hair regrowth in the privacy of the home using a device that has an output power much higher than existing home “hair removal” devices (enabling more effective hair-regrowth inhibition and a faster coverage rate) while also enjoying the convenience of compact device size and cordless (battery-powered) operation.
- the device may also be suited for use while plugged in, e.g., when it is not inconvenient to utilize the device while it is attached to an outlet or other source of electrical power. This can save battery power at times and can also serve to recharge the batteries.
- the concept is not limited in its advantageous application to hair-regrowth inhibition, nor to the preferred wavelength of approximately 800 nm; but rather, may be applied more broadly to dermatologic treatment utilizing battery-powered laser diode bars for other applications, and/or other wavelengths.
- benign pigmented lesions and unwanted leg veins may be treated by dermatologists in an office setting using an 800-nm laser diode bar source; and treatment of acne by destruction of the sebaceous gland is possible utilizing a similar laser diode bar source at 1400 or 1700 nm (both absorption peaks of sebum).
- the invention is also not limited to devices containing only one or two laser diode bars each containing multiple laser diode emitters, but may include a different number of laser diode bars and may include other alternative light sources such as solid-state lasers, semiconductor lasers, VCSEL's and flashlamps, among others that may be understood to those skilled in the art that generally meet the input and output criteria described herein for a battery-powered, home care device.
- An apparatus and method in accordance with a preferred embodiment include increased eye safety by increasing the divergence and reducing the spatial coherence of the light emitted from the output aperture of the dermatological apparatus.
- the output aperture may be a clipping aperture, but as used herein, is not so limited, and the term is meant to include any plane through which the light travels or transmits, and may comprise a particular solid material such as a window or optical diffuser or a fluid such as air.
- the apparatus and method may alternatively involve operation from a conventional wall outlet, eliminating the need for batteries.
- a “supercapacitor” i.e. a high-capacitance electrical component that has recently become commercially available, termed an UltraCapacitor by Maxwell, Inc. of San Diego, Calif.
- This device can provide very high current, but unlike a battery its output voltage decreases rapidly at constant current output, in addition to adding its own weight and volume.
- the handle of the preferred apparatus contains a rechargeable battery pack containing five “sub-C” size nickel-metal-hydride or similar batteries, capable of powering the device without a main storage capacitor or transformer for approximately 300-500 pulses between recharges. That is, the circuit of the preferred embodiment is a “direct drive” electrical circuit wherein the current flowing from the batteries during a light pulse is substantially equal to the current flowing through the light source, or is substantially equal to the sum of the currents flowing in parallel through multiple light sources. The voltage provided by the batteries will not be substantially greater than the voltage applied to the light source due to small voltage drops at various resistances in the circuit.
- the electrical battery serves as the source of electrical power in a preferred embodiment.
- the electrical battery could be comprised of (a) a battery that drives the light source directly, which is the preferred direct-drive electrical circuit, or alternatively (b) a battery that charges a supercapacitor that drives the light source, (c) a battery that charges a capacitor that drives the light source, (d) a supercapacitor that drives the light source directly, or (e) a supercapacitor that charges a capacitor that drives the light source.
- the chemical battery may be non-rechargeable, such as alkaline, or re-chargeable, such as nickel-metal hydride (Ni—MH). A rechargeable battery would provide greater convenience and lower cost for the user.
- Ni—MH battery of about 50 cm 3 and 170 g would provide for about 15 minutes of operation.
- the capacitor would be about 50 cm 3 and 50 g.
- Nickel-metal-hydride batteries are preferred over Li-ion batteries, which have substantially lower peak current capabilities.
- Ni—Cd batteries have undesirably low energy densities, although they do have lower series resistances.
- the Ni—MH batteries selected have a battery capacity of 3 Ampere-hours (Ah) at a voltage of 1.25 V and can easily generate the 500 pulses.
- Ah Ampere-hours
- These batteries are preferably and advantageously factory installed. That is, they are preferably only replaceable at the factory (e.g., during a refurbishment).
- An alternative consumer-replaceable battery embodiment, either disposable or rechargeable, involves a more complex design and higher cost.
- FIG. 11 shows the salient features of an electrical circuit in accordance with a preferred embodiment. Incidental components have been lumped into the various blocks of the circuit diagram. Although detail within each of the blocks is not shown, it is submitted that those skilled in the art can implement each of the blocks.
- the electrical circuit for powering and controlling the hair-regrowth-inhibition apparatus of the preferred embodiment is advantageously robust and efficient in driving a pair of laser diode bars within a cordless, hand-held, and self-contained device.
- the details of control electronics can vary greatly from the description below, and as schematically illustrated by the block diagram in FIG. 11 , and as shown in some more detail in FIG. 12 in accordance with a preferred and exemplary embodiment.
- the controller of the device is the processor 888 .
- a microcontroller such as a PIC18LF452, manufactured by Microchip Technologies of Chandler, Ariz.
- Such a controller has many analog I/O, digital I/O, onboard read access memory (RAM), nonvolatile memory (FLASH and EEPROM), and other features that make it inexpensive, small and convenient to use in a self-contained device that is relatively small and lightweight compared with conventional office-based devices.
- RAM onboard read access memory
- FLASH and EEPROM nonvolatile memory
- the device does not need to employ the use of a microcontroller, using one makes the capabilities of the device greater than it would be otherwise possible for a given size.
- ASIC application-specific integrated circuit
- the trigger button 826 is used by the operator of the device to signal that a treatment pulse is desired.
- a trigger switch 826 may be omitted if the contact sensors 819 and 820 are used as a means to signal that the operator desires a treatment pulse.
- the processor 888 communicates with the other blocks through various signals.
- the processor may communicate with peripheral devices through a serial interface port 836 .
- the processor may also have a programming port 837 by which the microcontroller may be programmed while preferably already soldered into the circuit.
- the programming port 837 may also be used with an in-circuit-debugger (ICD) to make design and debugging of the software more convenient.
- ICD in-circuit-debugger
- a device in accordance with a preferred embodiment is powered by battery pack 806 and DC/DC converter 887 .
- the number of batteries in the battery pack are sufficient to drive current through the laser diodes 800 , or LED, flashlamp or other alternative light source, current sense resistors 801 and 804 , and FET's 802 and 803 .
- the preferred battery configuration includes five batteries rated at 1.2 V each and providing between 1.0 V and 1.5 V during the course of a discharge period. The voltage provided by the battery pack 806 is then between 5.0 V and 7.5 V.
- the DC/DC converter 887 monitors the power button 825 , a wake-up signal 838 from the battery charger 886 , and a shutdown signal from the processor 888 .
- the DC/DC converter 887 signals the processor 888 if the power button 825 is depressed via the power switch signal 834 .
- a signal proportional to the battery voltage is communicated by the DC/DC converter 887 to the analog conditioning electronics 889 via the battery voltage monitor signal 827 .
- the DC/DC converter 887 produces the various voltage levels required to power the other blocks of the circuit, namely a reference voltage 828 , FET gate drive voltage 829 , electronics supply voltage 830 , and a switched battery voltage 831 that can be switched on and off by the DC/DC converter 887 .
- the blocks in the diagram shown in FIG. 11 preferably each have a connection to the signal common 807 which may or may not be shown. Since any switch between the battery and other components would develop a parasitic voltage drop, the battery pack voltage provided to the laser diode loop is not switched independent of the sentinel FET(s) 802 and control FET's 803 . The absence of a switch is shown via the battery signal 805 .
- the battery charger 886 is used to charge the battery pack 806 .
- a commonly available low power, 9 VDC, 500 mA power adapter (not shown) can be connected at the DC power jack 824 .
- the battery charger 886 has a fast-charge mode that charges the battery pack 806 with a current of about 450 mA and a trickle-charge mode that charges the battery pack 806 with a current of about 30 mA.
- the battery charge mode may be selected by the processor 888 via the fast charge signal 839 .
- the processor is informed of the charge state of the battery pack via one of the signals in the analog signal bus 841 .
- the battery charger can signal the DC/DC converter 887 to wake up via the wake-up signal 836 and can signal the processor 888 via the charge voltage monitor signal 840 . Because the processor knows of the presence of the power adapter and the charge state of the batteries, an intelligent algorithm may be used for fast recharging of the batteries 806 .
- the analog conditioning circuitry 889 amplifies and converts the signal impedance, where necessary, of the various analog voltages that are sent to the processor 888 .
- These signals include the laser diode cathode voltage 813 , the current sense signal 814 , the battery voltage 827 , skin sensor detector signal 842 , reference voltage 828 , and voltages representative of the temperatures sensors 850 , 851 , and 852 .
- the temperature sensors may be used to monitor the voltage of the finned heat exchanger; the cold side of the thermoelectric cooler elements 858 ; and the battery pack 806 and main circuit board.
- the conditioned analog signals are conveyed to the processor over the analog signal bus 841 .
- the purpose of the skin sensor circuitry 890 is to distinguish the presence of skin from other materials at the output aperture of the device.
- Light emitting diodes (LED's) 853 and 854 are used to illuminate the output aperture of the device. Remitted light is sensed by detectors 855 and 856 .
- the processor 888 may select which LED to illuminate via address bus 843 .
- the signal from detectors 855 and 856 are summed and communicated to the analog conditioning electronics 889 via the detector signal 842 .
- the processor 888 can then compare the detector signal for each LED against the known expected value for skin. In this way, skin can be distinguished from many other materials.
- five LED's, emitting light in the blue, green, yellow, red, and infrared portions of the electromagnetic spectrum are used. Simple silicon phototransistors are used to detect the remitted light. Greater or fewer LED's may be used to increase or decrease, respectively, the degree to which the skin sensor can reliably distinguish between skin and other materials.
- the fan and TE module electronics 891 provide power to the fan 857 and TE module 858 .
- a fan signal 844 and TE module signal 845 from the processor 888 determine if the fan and TE module electronics 891 provide power to the fan 857 and TE module 858 , respectively.
- Visual indicators used to communicate with the operator include three LED's, power 859 , ready 860 , and battery 861 .
- An audible indicator 862 is also preferably used to provide user feedback. The audible indicator is especially advantageous on a self-contained device since the operator may have difficulty seeing the device if used for self-treatment of areas of the body that do not enable the direct view of the visual indicators 859 , 860 , and 861 .
- the power indicator 859 is used to signal to a person that the device is on.
- the ready indicator 860 signals that the device has initialized, is at the proper operating temperature, and that the user may begin treatment.
- the battery indicator 861 signals the charge state of the battery.
- the contact sensor electronics 880 are used to detect contact of the output aperture and/or output window component of the device with a firm surface such as skin.
- One or more sensors, 819 and 820 may be used to sense contact of different portions of the output aperture.
- Three simple contact closures implemented through the use of a membrane switch commonly found in cell phone keypads, calculator keypads, or other electronics are used to detect contact in the device of the preferred embodiment.
- Other contact sensors using light, ultrasound, electrical resistively or other physical phenomena may be used.
- the state of the contact sensors are communicated to the processor 888 via the contact bus 821 .
- the processor may use a complex algorithm for determining if sufficient contact is provided before it signals the other control electronics that a treatment pulse may be initiated and maintained.
- the contact sensor electronics 880 also may directly (and redundantly) signal the pulse enabling electronics 881 via a contact signal 815 .
- the current control electronics 885 provide closed-loop control of the current flowing through the laser diodes 800 .
- the differential voltage across current sense resistor 1 ( 804 ) is monitored by the current control electronics 885 and is proportional to the current flowing through the laser diodes 800 .
- This differential voltage is amplified and compared to a set point voltage that can be adjusted by the current setpoint resistor 812 .
- the voltage on the gate of the control FET's 803 is continuously adjusted by the current control electronics 885 to ensure that the proper current is flowing.
- the current control electronics 885 turns off the control FET's 803 .
- the current limit electronics 884 are used to monitor the current flowing through current sense resistor 2 ( 801 ). In a similar fashion as the current control electronics 885 , the current limit electronics 884 amplifies the differential voltage developed across current sense resistor 2 ( 801 ) and compares this voltage with a voltage set by current limit resistor 811 . If the current flowing through current sense resistor 2 ( 801 ) exceeds the limit, then an over-current error is signaled to both the pulse enable electronics 881 and the processor 888 via the over-current error not signal 810 .
- the pulsewidth limit electronics 882 are used to monitor the pulsewidth of the treatment pulse.
- An independent time base (different from that used by the processor 888 ) is used to ensure the duration of any treatment pulse does not exceed a time set by the pulsewidth limit resistor 817 . If the processor 888 requests a pulse via the pulse not signal 823 that exceeds the pulsewidth limit then the pulsewidth limit circuitry 882 signals the processor 888 and pulse enable electronics 881 via the pulse width error not signal 818 .
- the pulse rate frequency (PRF, or repetition rate) limiting electronics 883 are used to ensure that treatment pulses are not emitted more frequently than desired. If sufficient time is not allowed by the processor 888 between pulses requested on the pulse not signal 823 , then the PRF limiting electronics 883 indicates an error to the pulse enabling electronics 881 via the PRF limit not signal 816 .
- the pulse enabling electronics 881 ensure signals from other blocks indicate that the other blocks have satisfied their requirements prior to the initiation of a treatment pulse. These signals may include: contact 815 , no over-current condition 810 , no pulsewidth error condition 818 , no pulse rate frequency (PRF) error 816 , and the presence of a processor enable signal 822 . If all of these enable signals are present, the pulse enable electronics 881 turns on the gate of the sentinel FET's 802 via a sentinel gate signal 809 . If at any time any of the signals that are monitored by the pulse enabling electronics 881 indicate that the pulse should not continue, the sentinel FET's 802 are turned off by the pulse enabling electronics 881 and the output may be terminated mid-pulse.
- signals may include: contact 815 , no over-current condition 810 , no pulsewidth error condition 818 , no pulse rate frequency (PRF) error 816 , and the presence of a processor enable signal 822 . If all of these enable signals are present
- the laser energizing circuit loop is shown comprised of the following elements: the laser diodes 800 , battery pack 806 , current sense resistor 1 ( 804 ), current sense control FET's 803 , sentinel FET's 802 , and current sense resistor 2 ( 801 ). This loop is shown in more detail in FIG. 12 .
- FIG. 12 shows the detailed schematics of the circuitry used to control the current to the laser diode bars.
- the battery pack 806 positive and negative electrodes are be connected at terminals J 4 and J 2 , respectively.
- the laser diode bar cathode and anode are connected at terminals J 1 and J 3 , respectively.
- Current sense resistor 1 , R 1 , and current sense resistor 2 , R 2 are shown as 0.002 ohm resistors.
- the current control FET's are shown as a parallel connection of two FET's Q 2 and Q 4 .
- the sentinel FET's are shown as a parallel connection of two FET's, Q 1 and Q 3 .
- Resistors R 3 , R 4 , R 5 , and R 6 are a part of the control electronics not shown discretely in the block diagram of FIG. 11 .
- Resistors R 3 and R 4 are connected to the gates of the sentinel FET's and current control FET's, respectively, so that the transistors turn off if either gate signal is for some reason disconnected.
- R 5 and R 6 are used to generate the laser diode cathode voltage signal 813 of FIG. 11 .
- the capacitors C 1 , C 2 , C 3 , and C 4 are used to reduce the switching noise of the FET's and may not be necessary.
- FIG. 11 and FIG. 12 show the salient features of an electrical circuit that can be used in accordance with a preferred embodiment.
- An advantageous feature of the design illustrated in FIG. 11 and FIG. 12 is that the laser diodes are powered directly by the battery pack.
- the phrase, “powered directly,” or, as used elsewhere herein, the phrase, “direct drive,” are intended to mean that the instantaneous current flowing through the battery and the instantaneous current flowing through the laser diodes at a particular moment in time are substantially equivalent.
- the instantaneous currents differ only in that a small amount of current drawn from the batteries is used to power the control electronics.
- This architecture is markedly different from and advantageous over state-of-the-art laser systems and flashlamp systems used for hair-regrowth inhibition due to various efficiencies that it provides.
- FIGS. 11 and 12 There is significant architectural advantage in the circuit of FIGS. 11 and 12 over conventional pulse power circuits for delivering 40 ampere current pulses for energizing pulsed laser systems.
- Most circuits that are capable of delivering large current pulses rely on a main storage capacitor to store the electrical charge that is to be delivered during the pulse.
- state-of-the-art hair removal systems like the LightSheer diode laser system, the Quantum flashed lamp system, and the Altus CoolGlide all have large banks of capacitors that are re-charged by a DC power source between pulses.
- the system of the preferred embodiment includes a direct drive electrical circuit. As described above, the circuit directly switches current pulses from the batteries to the laser electrodes and does not include a main storage capacitor.
- Such main storage capacitor would involve a large bank of capacitors due to the low energy density of capacitors.
- no step-up or step-down transformer is used in the direct drive electrical circuit. This permits the size and weight of the apparatus of the preferred embodiment to be significantly less than a circuit including a main storage capacitor and/or transformer; and so in accordance with one of the goals of the design of the preferred embodiment, the additional size and weight of a main storage capacitor bank and transformer are avoided.
- laser diode bars 800 are used to represent the series connection of one or more, and preferably two, laser diode bars.
- Laser diodes are much more efficient at converting electrical power to optical power than other lasers.
- two laser diode bars are connected in series.
- Laser diode 800 can be 40-watt, 808-nm packages manufactured by Cutting Edge Optronics, of St. Charles, Mo., part number ASM06C040W080810B80 or similarly packaged laser diode bars 800 .
- a single diode bar 800 may be used if the optical power delivered is sufficient for therapeutic results.
- an efficient laser source is preferably combined with efficient batteries and circuit design in order to realize a self-contained and hand-held hair-regrowth-inhibition device.
- the size of the batteries and the electrical circuit configuration are such that main storage capacitors are not required. Instead, the laser diodes are driven “directly” from the DC power source, or the battery pack.
- the batteries are capable of supplying approximately 40 A without damage.
- the most recent battery technology is lithium-ion, nickel-metal hydride or alternatively, nickel-cadmium, are preferred, because the maximum peak current draw is much greater than Li-ion can provide, for a given battery size.
- ESR equivalent series resistance
- the batteries that comprise battery pack 806 may be Panasonic HHR300SCP Ni—MH rechargables, Panasonic P-170SCRP NiCd batteries, sold by Panasonic Matsushita Electric Corporation of America, Secaucus, N.J., or similar batteries.
- FIG. 12 Another advantage of the circuit design of the preferred embodiment is that voltage drops are minimized and/or avoided in many places.
- the laser diode bars are shown connected in series with the battery, FET's and current sense resistors. Minimizing the voltage developed across the components powered by the batteries is advantageous because this will determine the minimum voltage and hence the minimum number of battery cells that are included in the design and thus in part establish a lower limit on the weight and size of the apparatus. Voltage drops across the FET's, the current sense resistors, the laser diodes, the battery series resistance, and the circuit board traces and the other interconnections between these components have been taken into consideration.
- the current sense resistors 804 and 801 are redundant current-sense resistors.
- the resistors are redundant for safety reasons. Each is used by a different sub-circuit to ensure that currents larger than desired are not permitted to flow through the laser diodes. Because of the large currents flowing through them (approximately 40 A each), an appreciable voltage will develop with even a small value of resistance. For this reason, components that are commonly thought of as resistors are not used, and instead, merely 1.5 inch lengths of 22 gauge copper wire are used. These lengths of wire have a resistance of only approximately 0.002 ohms, so that a voltage of approximately 80 mV develops across each of them when the laser is pulsed. Differential amplifiers within the current control electronics 885 and current limit electronics 884 serve to amplify the voltages to levels that are more readily used by the feedback circuitry.
- the control FET's 803 are the FET's that control the current flowing in the circuit. Any excess voltage supplied by the batteries, that is, voltage greater than that involved in driving the desired current through the laser diodes, is dropped across the control FET's 803 . However, as the batteries are discharged and the battery voltage decreases, there will not be excess voltage supplied by the battery, and so the voltage that develops across the FET's for the case when the batteries are nearly depleted is advantageously minimized in accordance with a preferred embodiment, because the FET's chosen have very low on-resistance (r ds-on ).
- the transistors shown, IRL3716 International Rectifier Corp., El Segundo, Calif.
- IRL3716 International Rectifier Corp., El Segundo, Calif.
- IRL3716 International Rectifier Corp., El Segundo, Calif.
- two transistors in parallel are preferred instead of just one so that only approximately 20 A flows through each transistor.
- the sentinel FET's 802 are used to shut off the current if an error condition exists (for example, if one of the control FET's 803 fail such that current flows when it should not).
- the sentinel FET's 802 are chosen with preferably the same criteria as the control FET's 803 with one exception. Since the sentinel FET's 802 are used only digitally to permit any current set by the control FET's 803 or restrict any current, the FET's are either turned on “hard” or else turned off completely. In both of these states, little power is dissipated by the sentinel FET's 802 and so the transistor's packaging can have worse thermal performance than the packaging of the control FET's 803 . For this reason, in FIG.
- transistors such as IRF7832 (International Rectifier Corp.) may be used for transistors Q 1 and Q 3 .
- IRL3716 transistors would be acceptable for use as FET's 802 ; however, they would undesirably add to the size, cost, and weight of the device.
- the series resistance of the FET's is further reduced by enabling the circuit to supply relatively high voltages to the gates of each of the transistors.
- the on-resistance of FET's sharply depends inversely on the magnitude of gate-to-source voltage applied to the device.
- the DC/DC converter electronics 887 in FIG. 11 produce an FET gate drive voltage 829 .
- the gate drive voltage 829 produced by the DC/DC converter is 7.6 volts even when the battery pack voltage drops to less than 5 volts. This voltage is greater than the battery pack voltage and is present so that the FET gate-to-source voltage, Vgs, of each of the FET's can be driven to a greater value than would be possible if the magnitude of the voltage was limited by the battery pack voltage. This is especially true as the batteries become depleted and the battery voltage decreases to less than its fully charged level.
- the control FET's 803 and sentinel FET's 802 are located in a way that minimizes the length of the traces and interconnects, isolates the current paths from sensitive circuitry, and provides a means of conductively rejecting the waste heat produced by the transistors to the finned heat exchanger 620 of FIG. 10 .
- Wide, short traces and redundant traces on multi-layer boards achieve this.
- conventional electrical connectors are not used in the high current path so as to eliminate connector resistances. Instead, components are soldered at the factory. This represents a trade-off between ease of manufacture and repair with reductions in voltage drops throughout the circuit, wherein even milliohm parasitic resistances are avoided wherever possible.
- an exemplary device in accordance with a preferred embodiment may produce light pulses according to the following summary of parameters:
- Pulse repetition frequency 0.5 Hz
- the peak optical power is 60 W and coverage rate is 30 cm 2 per minute. These provide efficacious and practical treatment specifications. As will also be detailed below, these particular parameters fall within ranges for minimum and maximum quantities for the preferred device. These ranges preferably include:
- Output fluence range 4 J/cm 2 to 100 J/cm 2
- Pulsewidth 0.010 s to 1 s, or more preferably 0.100 s to 0.500 s
- Pulse repetition frequency 0.1 Hz to 2 Hz
- Wavelength 700 nm to 1100 nm
- Optical Peak Power 10 W to 120 W.
- output fluence is intended to describe the fluence at the output aperture or output window of the dermatologic treatment apparatus.
- the output fluence of the device is also termed below as F source .
- a source fluence F source between 4 J/cm 2 and 100 J/cm 2 .
- F source For pulse durations in the 0.3 ms to 3 ms range, temporary hair regrowth inhibition has been found clinically with output fluences as low as 4-5 J/cm 2 .
- output fluences below about 10 J/cm 2 are unlikely to have significant effect. In the absence of actual clinical trials at these parameters, it cannot be established more precisely, and in any case will vary from person to person and even with body site on a single person.
- the fluence that the skin can tolerate is generally affected by at least four parameters.
- the first is the extent to which the epidermis is kept from rising in temperature while the target below is heated.
- the preferred device includes a thermally-conductive contact surface made of sapphire, or alternatively incorporates some form of active cooling of the contact surface or the skin such as using a fan. Alternatively, cryogen spray may be used to cool the skin to be treated.
- the laser diode bars of the light source 140 preferably emit light pulses such that a majority of the energy is in the spectral band of 700 nm to 1100 nm, and particularly around 800 nm, although visible wavelengths may also be used; bandwidths between approximately 1 nm and 10 nm; pulse durations preferably between 3-10 milliseconds (ms) and one second, and more preferably between 100 ms and 500 ms and particularly around 300 ms, at a repetition rate of between 0.1 Hz and 2 Hz, and particularly between 0.25 Hz and 1 Hz.
- wavelength of the light Another significant parameter is the wavelength of the light.
- melanin in the hair shaft and follicle absorbs light, resulting in thermal injury to the follicle and delayed regrowth.
- light having a shorter wavelength would be preferred, since these wavelengths are more strongly absorbed.
- the melanin in the skin overlying the hair follicle also absorbs more light at these wavelengths, reducing the fluence tolerated by the skin.
- Theoretical calculations and clinical results have determined that optimum results for hair-regrowth inhibition are obtained for most skin types when the light source has an output in the spectral band between 700 nm and 1100 nm. Wavelengths longer than 1100 nm, in addition to having very low melanin absorption, also become problematic due to water absorption, which begins to limit optical penetration depth making the apparatus less efficient.
- the preferred wavelength of emission of the light source 140 is thus between approximately 700 nm and 1100 nm.
- a wavelength of 500 nm to 1100 nm may be preferred, since flashlamps are inherently broadband sources, and thus a broader wavelength range may be involved for achieving the desired fluence.
- LED's are utilized as the light source
- higher power LED's may be available at wavelengths below 700 nm; thus a wavelength range of 600 nm to 1100 nm may be preferred.
- the pulses emitted by the light source 140 are generated preferably by energizing the laser diode bars with 40 A for less than half a second. Therefore during the application of this energy, the laser diode material warms from about 20.degree. C. to about 50.degree. C., or a difference of 30.degree. C. over the duration of the pulse.
- the emission wavelength particularly of III-V emitter materials such as Al x Ga 1-x As varies with temperature. For example, ⁇ (T) may vary by about 0.3 nm/.degree. C. Therefore, the emission wavelength may vary by about 9 nm during the pulse, and the effective bandwidth of the pulse is then generally about 1 nm and may be between about 5 nm and 10 nm. Where used herein, bandwidth is defined as the full-width half-maximum of the energy spectrum.
- Sources such as diode lasers or LED's, that typically have bandwidths of less than 40 nm, are generally preferred over flashlamps because they have higher electrical-to-optical conversion efficiency.
- the repetition rate of pulses is preferably between approximately 0.1 Hz and 2 Hz, and particularly between around 0.25 Hz and 1 Hz, or between one pulse every second to one pulse every four seconds.
- a repetition rate any faster than 1-2 Hz is not desired owing to the expense and weight of a device capable of producing pulses this rapidly.
- the self-care user of the device whether it is a person at home applying the light to his or her own skin, or a user treating another person's skin, would find it difficult to manipulate the apparatus over the application area of the skin at higher repetition rates.
- a repetition rate slower than one pulse every four to ten seconds would render the coverage rate of the apparatus annoyingly slow for home use. That is, the application time simply becomes too long even for small treatment areas.
- a higher repetition would translate into a higher coverage rate or more skin area treated per minute, which is desirable.
- a higher repetition rate also involves a higher average input power since the average optical power is higher.
- This higher electrical power requirement in addition to increased volume, weight and cost, creates a problem of waste heat from the laser diode bars of the preferred apparatus.
- Another important parameter is pulse duration. If the epidermis is kept from rising excessively in temperature, the energy can be continued to be applied into the hair follicle over a time that is roughly the thermal relaxation time of the stem cell region of the follicle, e.g., for approximately 100 ms to 500 ms. With contact cooling, the epidermis is kept from getting too hot; and much more fluence, or energy over a given area, can be applied into the dermis if it is applied over a longer time period.
- the preferred pulse duration of the apparatus is above 3-10 ms and below approximately one second or even 500 ms. Pulse durations below around 10 ms, and particularly below 3-8 ms, are not desired for the light-based hair-regrowth-inhibiting apparatus, because to achieve adequate energy deposition in such a short time requires high optical peak powers. For example, application of an energy density of 20 J/cm 2 in a 0.8 cm 2 spot area (16 J) in a 10 ms pulse involves a optical peak power of 1600 W. This very high peak power is expensive to generate. For example, with diode laser bars each having a optical peak power of 30 W, over 50 bars would be used, and this is too many for a self-contained, hand-held and cordless device.
- the thermal relaxation time of the hair follicle is generally at least 10 ms and may be as high as 100 ms to 600 ms for the stem cells surrounding the hair follicle, and so for the reasons provided, it is particularly desired to have pulse durations at least as long as this thermal relaxation time, such that a particularly preferred minimum pulse duration may be 100 ms or more.
- pulse durations get too long, such as above between 600 ms and one second, heat which is initially deposited into the melanin-laden hair shaft diffuses beyond the hair follicle.
- a transition gradually occurs from spatially-selective heating of just the follicle (and surrounding stem cells) to so-called bulk-heating of the dermis.
- the pulse duration is increased at constant energy (or constant fluence)
- the optical peak power eventually gets so low that the target does not get sufficiently hot to cause hair-regrowth inhibition.
- the peak power is kept constant as the pulse duration is increased, the fluence can get so high that the bulk heating becomes painful and/or may even cause skin burns.
- pulse or pulse duration
- pulse is intended to include not only a single pulse in the conventional sense, but also a train of discrete pulses (“sub-pulses”) or modulated pulse over the same time duration.
- sub-pulses are considered to be one pulse if the time duration between the start of the first sub-pulse and the end of the last sub-pulse in a group is less than the time period between groups of such sub-pulses.
- the spot size, or area of skin illuminated by light pulses propagated from the apparatus is too small.
- the spot size on the skin and the output aperture of the device are approximately equal in size.
- a very small spot e.g., less than 0.25 cm 2
- some sort of visual targeting would be involved to ensure that the spot is indeed over a target follicle.
- a small spot implies a very low coverage rate; i.e.
- a larger spot size is desirable primarily because of enhanced coverage rate. For example, at a spot size between 2 cm 2 and 4 cm 2 spot size per pulse, entire legs could be treated in less than 30 minutes, assuming a pulse repetition frequency of roughly one pulse per second. However, for a given output fluence and pulse duration, the optical peak power required scales linearly with the spot size, and the cost and weight become prohibitive once the spot size gets above approximately 1.0 to 2.0 cm 2 .
- an alternative embodiment of the apparatus includes means of lowering the output fluence either continuously or discretely in a high-medium-low embodiment, where the high setting still corresponds to a maximum potential fluence at the eye of a person below the maximum permissible exposure (MPE) as detailed below.
- MPE maximum permissible exposure
- Increased divergence and reduced spatial coherence, and resulting increase in eye safety, is accomplished by incorporating into the path of the beam of light within the apparatus, a diffusing material through which the light travels prior to leaving the apparatus, as in the second embodiment shown in FIG. 2A .
- the divergence may be increased and spatial coherence reduced by incorporating into the device a diffusing surface upon which the beam strikes prior to leaving the device, as in the third embodiment shown in FIG. 2B .
- the fluence of the light emitted by the output aperture will generally decrease as it propagates away from the apparatus due to the divergent nature of the beam, many of the chromophores within the skin that are targeted by light-based treatments are near the surface of the skin. If the target is much closer to the surface of the skin than the size of the output aperture of the apparatus, there will be little decrease of fluence at the chromophore due to divergence of the emission.
- the decrease in fluence at the target when using a very divergent source with little or no spatial coherence is relatively insignificant when compared to the fluence at the target produced by a collimated light source that has equal fluence at the surface of the skin; provided that the distance from the output window or aperture of the source to the target beneath the skin surface is small compared to the lateral dimension of the source (e.g., the diameter of the output window).
- MPE Maximum Permissible Exposure
- the actual value of the MPE varies greatly depending on the characteristics of the light source in question; specifically, the source wavelength, pulse duration, coherence, and, if incoherent (e.g., from a diffuse source) the angle formed by the dimension of the source and its distance from the cornea (the so-called angular subtense that determines the size of the corresponding image of the source on the retina; see International Standard IEC 60825.1, “Safety of Laser products—Part 1: Equipment classification, requirements and user's guide”, Edition 1.2, August 2001; p. 11.).
- the second value “F cornea ” is the fluence produced at the cornea from a particular light source, as measured through a pair of apertures limiting the angle of acceptance to 100 milliradians (see IEC 60825.1, above, p. 40, NOTE 2, sub-note d.).
- the value of F cornea depends upon both the fluence produced by the device at its output (the “output fluence”), as well as how the light diverges from the output as it propagates toward the eye. For any light source, if F cornea is less than the MPE for all possible distances between the source and the eye, the device is considered eye-safe. Conversely, a light source that produces, at any particular distance, a value for F cornea that exceeds the MPE is considered hazardous.
- t is the pulse duration in seconds
- C 4 is a correction factor for the wavelength ⁇ of light, having the following values:
- C 4 increases from a value of 1 at 700 nm and has a value of 5 at 1,050 nm;
- C 6 is a correction factor that is equal to 1 for coherent sources (this is strictly correct for sources that have a spatial coherence near the diffraction limit; for multimode sources or for arrays of coherent sources the calculation is more complex); and for diffuse, extended sources is given by C 6 ⁇ / ⁇ min where ⁇ min is equal to 1.5 milliradians and a is the angular subtense of the source, i.e.
- d is the diameter of the source and r is the distance from the source to the cornea.
- Equation 3 applies only up to an angular subtense of 100 milliradians; above this angle, a value of 66.7 is used for C 6 .
- An incoherent, directed source e.g., a flashlamp having a rectangular output aperture of 1 cm by 2 cm and a 30 ms pulse duration.
- the beam is designed to be highly divergent upon leaving the exit aperture; for example, by passing the beam through a very fast f/0.8 concave lens as shown in FIG. 4 .
- f/0.8 lens has a focal length equal to 0.8 times its diameter.
- This beam exits the lens at an angle ⁇ of about 0.56 radians, or 32 degrees.
- the fluence at a distance r from the exit aperture is given by (this is approximately correct for a Gaussian beam from a diffraction-limited laser):
- Q is the energy of the source. So for a source of 5 J/cm 2 output fluence from a 1 cm 2 aperture, the fluence at a distance of, for example, 20 cm (i.e. the output aperture of the device is 20 cm from the eye) is approximately 50 mJ/cm 2 still several thousand times above the MPE.
- any adjustment factors for pulse duration or longer wavelength to increase the MPE would not be nearly sufficient to make this device eye safe; for example, increasing the wavelength to 1050 nm and the pulse duration to 300 ms results in only a roughly 30-fold increase in MPE, to about 4000 ⁇ J/cm 2 (i.e., increase due to pulse duration is (300/30) 0.75 or about 5.6; increase in A from visible to 1050 nm increases C 4 from 1 to 5; so combined increase is 5.6 times 5, or about a factor of 28).
- An Incoherent, Directed Source e.g., a Flashlamp
- a popular device for hair-regrowth inhibition as well as for facial “rejuvenation” utilizes a flashlamp with visible and near infrared output and an exit aperture of 1 cm by 2 cm, and an output energy of 80 J (40 j/cm 2 ) (see Hode, L, “Are lasers more dangerous than IPL instruments?” Lasers in Surgery and Medicine, Supplement 15, 2003, p. 6; and poster presentation at corresponding conference).
- Such sources typically have a directed output of about plus or minus 20 degrees, i.e.
- the angular subtense is the arithmetic mean of the larger and smaller angular dimensions of the source. It should be noted that, once the source subtends an angle greater than 100 milliradians (i.e. comes yet closer to the eye) the hazard to the eye remains the same, because although the irradiance on the cornea increases, the image area on the retina increases proportionally. From Equation 1:
- the fluence F at a distance r from a source of energy Q directed into a solid angle .OMEGA. is approximately:
- a light source 310 which can be either a coherent source such as a laser or an incoherent source such as a flashlamp, impinges on a diffuser 320 .
- the diffuser in turn emits the scattered light preferably as an approximately Lambertian source in the forward direction (see Earle Brown, Modern Optics, Reinhold Publishing Corporation, 1965; p. 225).
- Light backscattered from the diffuser toward the laser or flashlamp can be reflected to impinge once again on the diffuser by incorporating reflective walls in the chamber 330 and on the surface of light source holder 340 that faces chamber 330 .
- the diffuser 320 need not be located at the exit aperture, but may be recessed within chamber 330 ; in this case the walls of chamber 330 between the diffuser 320 and the exit aperture should be non-absorbing.
- the diffuser has the added advantage of removing any “hot spots” from the light source; i.e., a source such as an array of diode laser emitters has much higher integrated radiance in some directions than in others; such localized variations will be smoothed out by a diffuser.
- a disk diffuser of the Oriel type is described, but the invention can also be effected with a different type of diffuser, as defined earlier.
- the fluence at the cornea is equal to the MPE of 13.6 mJ/cm 2 when Q is equal to 5.5 joules. Since our source has an aperture of 1 cm 2 , this corresponds to a source fluence of 5.5 J/cm 2 .
- our invention can have a source fluence of 5.5 J/cm 2 for providing an intended photothermal injury to the skin and yet have an output below that which would result in an exposure to the eye in excess of the MPE:
- the fluence at the cornea from the device must be less than the calculated MPE for all distances between the source and the eye, not merely the distance chosen in the above example. This can be shown to be true, as follows.
- the MPE remains the same.
- F cornea remains constant because, as described above, it is measured through apertures limiting the angle of acceptance to 100 mrad.
- F cornea is less than the MPE at a source distance corresponding to an angular subtense of the source of 100 mrad, it is also safe at lesser distances.
- the values for MPE and F cornea vary as follows: as the distance increases, the MPE remains constant, but as above, F cornea continues to decrease as the square of the distance. Thus one can conclude that the above source is safe at any distance.
- one or both of the following additional features is preferably included to allow even higher device fluences that are nonetheless still eye-safe.
- These features include an increase of the pulse duration of the light (e.g., from 30 ms to 300 ms), and an increase in the wavelength of the light (e.g., from visible to infrared); both of which result in a higher MPE for the eye and thus allow an increased therapeutic output that is still eye-safe.
- the benefits of each of these elements can be quantified, as described above and below. In short summary, however, pulse durations in excess of 100 ms and wavelengths above 700 nm are preferred, while as maxima, pulse durations are maintained at or below 500 ms and wavelengths below approximately 1100 nm.
- the pulse duration can also be extended to preferably 300 ms from 30 ms, or in a preferred range between 100 ms and 500 ms.
- pulse durations of 300 ms or greater are and/or may be an effective optimum. From Equation 1, in this case the MPE increases by a factor of (0.3/0.03) 0.75 or about 5.6.
- the light source in our example can have an output fluence 5.6 times greater than calculated above, or approximately 31 J/cm 2 , and it will still not exceed the MPE at any distance.
- AEL 10 k 1 k 2 t 1/3 J/(cm 2 sr ).
- the device will be below the Class I Accessible Emission Limit if the source fluence is less than 32.6 J/cm 2 , a value that agrees well with the 31 J/cm 2 calculated earlier from the IEC limits for Maximum Permissible Exposure.
- a diffuser to a light-based dermatologic device to permit therapeutic fluences at the skin surface while ensuring eye-safe operation is by no means limited to the preferred and alternative embodiments described above and elsewhere herein.
- a device for the treatment of acne using blue or other visible light can be made eye safe at therapeutic fluences by the addition of a diffuser; and a device for repigmentation of skin, or treatment of psoriasis or vitiligo, using ultraviolet light (290 nm to 400 nm) can also be made much safer with a diffuser added to the output aperture.
- such devices contain incoherent sources with a directed output; i.e.
- the output beam expands from the output aperture by ⁇ 20 degrees, corresponding to a solid angle of about 0.4 steradians.
- the output propagates into a full 2 ⁇ steradians; if the diffuser creates a Lambertian distribution of the light (as is the case with an Oriel-type diffuser) the angular dependence of the output fluence will have the well-known cosine dependence, while other elements also described as diffusers for the purposes of this application may have a more general variation of fluence with viewing angle.
- typical devices without a diffuser i.e. devices which may have, for example, a light output spreading into .about.0.4 steradians
- are viewed on-axis i.e.
- the addition of the diffuser reduces the fluence at the cornea by the ratio of (0.4/ ⁇ ), or about 0.13, without affecting the fluence of the device when applied to the skin.
- a device that produces a fluence at the cornea which exceeds the MPE by up to eight times can be made eye safe by the addition of a diffuser.
- the fluence can be increased by up to an additional factor of two (while still remaining eye-safe) by altering the output distribution of the light from Lambertian to that approaching a uniform source. This can be effected, for example, by creating concentric micro-grooves (either by diamond-machining of sapphire or casting of plastic) such that an increased fraction of the light is refracted into higher angles, as illustrated at FIG. 3B , or incorporating a point source and mirrored chamber design as illustrated at FIG. 3D .
- the heat removal element may be a thermal battery that is “recharged” (i.e., heat is removed) or replaced prior to use and absorbs heat during use.
- the thermal battery may be a phase-change material, such as ice, certain paraffin-like waxes or salts such as TEA29 from TEAP Energy, or may be a high-heat capacity material like copper or aluminum or water, or may be a compressed gas or liquid that cools by expansion to lower pressure.
- a pigmentation sensor may be included that senses the amount of pigment in the skin.
- Such a sensor may be used to adjust output parameters such as pulse duration or pulse energy or to prohibit operation for pigmentation levels higher than a pre-selected threshold.
- a means of operation that is sliding, rather than sequential spot-wise treatment may be employed. By sliding, it is meant that the device is operated by continuously sliding the active area of the device across the skin. The light may be delivered in pulses or continuously. The device may provide feedback to the user to help maintain dosimetry within a given range and/or may have a mechanism or internal feedback, such as provided by an optical or mechanical sensor, to help maintain dosimetry within a given range.
- non-contact cooling may be employed, such as spray cooling or liquid cooling or cooling with an gel applied to the skin.
- reflective or diffusive surfaces or elements on or within the device may be used that may redirect light that has been scattered back to the device from the skin back into the skin. Such redirection of remitted light may occur by specular or diffuse reflection, such as from a partially transmissive diffuser near the output aperture or from reflective surfaces within or on the device. (As stated earlier, the term “reflective” is used in this context to include remissive surfaces.)
- the invention can also be advantageously applied to other dermatology applications, including treatments for acne, benign pigmented lesions, vascularity, skin texture, skin wrinkles, and “photo-rejuventation” which is generally accepted in the field to mean skin treatment for pigmented lesions (including brown and red spots), vascularity (including the destruction of small blood vessels), and/or skin tone, skin texture, and skin wrinkles.
- treatments for acne, benign pigmented lesions, vascularity, skin texture, skin wrinkles, and “photo-rejuventation” which is generally accepted in the field to mean skin treatment for pigmented lesions (including brown and red spots), vascularity (including the destruction of small blood vessels), and/or skin tone, skin texture, and skin wrinkles.
- the invention may be modified from the preferred embodiment hair-regrowth-inhibition device to make the device more optimal for the application.
- a wavelength between 350-450 nm may be chosen for its photodynamic effect on the porphrins produced by the acne bacteria.
- a wavelength in the range 1000-1800 nm may be chosen to match the absorption spectrum of sebum, a major component in acne.
- a broad-band source such as a flashlamp, may be used in order to simultaneously treat vascular and pigmented lesions and improve skin tone, texture, and wrinkles.
- somewhat shorter wavelengths have been shown to be efficacious; e.g., 500-1100 nm.
- the output fluences are generally desired to be greater than 4 J/cm 2 to be efficacious and the light is generally not eye-safe at these levels, although in accordance with a preferred embodiment, a diffuser is employed to reduce the maximum fluence at a person's eye to below the MPE.
- “divergent” light sources such as diode laser light sources are referred to herein.
- Light is defined herein as “divergent” when the divergence angle .alpha. is greater than approximately ⁇ 6 degrees, where the divergence is defined as the geometric mean of the half-angle formed between the principal propagation axis (z-axis) and the full-width half-maximum (FWHM) energy axes in the x and y coordinate directions. That is, if the divergence from the z-axis in the x-direction is ⁇ x and the divergence in the y-direction is ⁇ y , then the divergence ⁇ equals the square root of the quantity ⁇ * ⁇ y .
- diode laser bars typically have a FWHM beam divergence of about ⁇ 20 degrees in one axis and about ⁇ 5 degrees in the other axis, so have a typical divergence of about ⁇ 10 degrees as defined here.
- diode laser bars are a divergent light source.
- Diode lasers in general, flashlamps, and LED's are also typically divergent sources.
- a divergence value of 6 degrees clearly differentiates “divergent” sources, such as diode lasers and flashlamps, from “collimated” sources, which in practice have some divergence but typically less than 1 degree.
- Divergent light sources are superior to other light sources for achieving eye safety, in that a significant portion of the light from such divergent sources striking the diffuser is already partially directed at significant angles from the principal propagation direction. Thus the task of the diffuser to spread the light into large angles is simplified.
Abstract
Description
- This application claims the benefit of priority under Section 35 USC 119(e) to U.S. provisional patent applications No. 60/450,243, filed Feb. 25, 2003; 60/450,598, filed Feb. 26, 2003; 60/451,091, filed Feb. 28, 2003; 60/452,304, filed Mar. 4, 2003; 60/451,981, filed Mar. 4, 2003; 60/452,591, filed Mar. 6, 2003; 60/456,379, filed Mar. 20, 2003; 60/456,586, filed Mar. 21, 2003; 60/458,861, filed Mar. 27, 2003; and 60/472,056, filed May 20, 2003 and also U.S. Pat. No. 10,783,603, filed Feb. 19, 2004, all of which are incorporated herein by reference.
- 1. Field of the Invention
- The invention relates to a dermatologic treatment apparatus and method, and particularly to an apparatus that is light-based, yet eye-safe.
- 2. Description of the Related Art
- The introduction of specialized lasers for physician-performed epilation in 1996 (and intense-pulsed light, or IPL, sources shortly thereafter) represented the first real advance in the treatment of unwanted hair since the invention of electrolysis in the late 1800's. The use of lasers and flashlamps in these devices has not only proven to be safe and effective, but unlike electrolysis allows for the treatment of multiple hairs at a time, greatly improving coverage rate.
- Light-based epilation with lasers is often termed “laser hair removal”, although this term is strictly correct only when follicles undergo sufficient thermal damage to permanently prevent the growth of new hairs (“permanent hair reduction”). Procedures that thermally damage follicles to induce a delay in hair regrowth are more accurately described as hair-regrowth inhibition.
- Methods and devices for light-based epilation are now widespread and an estimated three million people worldwide have undergone treatment. This represents a very small section of the potential market, largely because of the high cost and inconvenience associated with physician-based procedures and devices. As a result, there is a desire for lower cost, more compact devices that would lower the cost of physician-based treatments and, ultimately, help enable salon and consumer markets. There is also a desire for devices with enhanced eye safety.
- The introduction of the LightSheer Diode Laser System by Star Medical in 1997 for hair-regrowth inhibition (and subsequently, for permanent hair reduction) marked the beginning of one of the most successful aesthetic laser applications for the dermatologist's office. With several thousand systems installed worldwide, the safety and efficacy of these and similar devices that followed have been well established. Other such devices include the SLP 1000 (LC 100) diode laser of Palomar Medical Technologies, the Apex 800 diode laser of IRIDEX Corporation, and the F1 diode laser of Opus Medical, Inc.
- The radiant exposure applied to the skin (often referred to as “fluence”, expressed in joules per square centimeter) by this class of devices is typically in the 10-40 J/cm2 range at a wavelength of nominally 800 nanometers. It was initially believed that pulse durations in the 5-30 ms range are optimum; however, subsequent studies showed that longer pulses (up to at least several hundred milliseconds) can quite effectively achieve hair-regrowth inhibition, and can also reduce epidermal heating for a given fluence when a heat conduction path is provided (e.g., by incorporating an output window made of sapphire in contact with the skin).
- The high efficiency and small size of the semiconductor diode lasers utilized in these devices generally permit the manufacture of compact systems (typically 1-3 cubic feet in volume) and simple 115 VAC operation. However, the systems typically weigh at least 25-100 pounds and sell in the range of $40,000 to $90,000. A much lower cost, truly portable device would make this popular procedure much more widely available.
- Lasers and intense light sources have gained increasing acceptance among dermatologists for effective treatment of a wide range of applications, such as hair-regrowth inhibition and permanent hair reduction, removal of tattoos, treatment of birthmarks, and facial resurfacing. It is well understood by medical professionals, however, that such light sources are capable of serious eye damage or blindness. To achieve reasonable efficacy with many light-based dermatologic procedures, such as reduction of unwanted hair or destruction of small blood vessels, the fluence on the skin typically exceeds 1 J/cm2. These devices produce a fluence at the human eye that is much greater than the maximum permissible exposure, causing such devices and the treatments performed with them to be extremely hazardous if not used or conducted properly. These procedures therefore involve the undertaking of adequate safety measures to protect the eyes of not only the patient, but the laser operator and any other personnel that may be in the same area. (See, for example, IEC Technical Report 60825-8, Safety of laser products—Guideline for the safe use of medical laser equipment.) As stated in the IEC report, with some medical lasers the retina may be exposed to an irradiance that is more than 100,000 times higher than the irradiance incident on the skin or cornea, due to the focusing action of the eye.
- With proper safety precautions, such as safety goggles and training of personnel, the risk of eye damage can be greatly reduced. As a consequence, reports of eye injuries to either patients or staff are rare in medical settings. However, risk of eye injury is a constant concern.
- The safety of a light-based dermatologic device can be increased by incorporation of a contact sensor that enables device operation only when in the sensor is in contact with a surface, such as a person's skin. For example, the light source (laser, light-emitting diode, flashlamp, etc.) can be placed within a housing having a single open end through which the light propagates; a contact sensor at this open end can enable operation of the device only if the housing is placed up against a contacted surface. In this manner light can only propagate into or through the surface against which the device is placed. However, use of any type of sensor added to increase eye safety adds complexity and may, of course, fail. Thus, the ideal dermatologic treatment device and method would not depend on electronic circuitry or user compliance with safety eyewear for safe use.
- Thus it is highly desirable that any light-based device intended for medical application be designed to minimize possible eye damage for a given level of output fluence or therapeutic benefit, by increasing the inherent eye safety of the light. Existing laser hair reduction devices, for example, are much more hazardous to the eye than necessary because their output is highly directional and easily focused by the eye. If their output could be made more highly divergent and/or to have reduced spatial coherence, there would be a greatly reduced risk of eye injury, without significant loss of efficacy.
- Examples of office-based, light-based systems for dermatological treatment are described in U.S. Pat. Nos. 6,508,813, 6,277,111, 6,197,020, 6,096,029, 5,885,273, 5,824,023, and 4,232,678, and U.S. published application no. 2002/0005475, and published PCT application no. WO 03/049633. The '5475 published application uses a contact sensor for enabling laser pulses only when the handpiece is in good contact with a patient's skin. One problem with application of such a device in a home use, self-care setting is that a small child, or person attempting to treat eye lashes or eye brows with the device, may still inadvertently shine pulses into their eyes and potentially cause permanent damage to their vision. Similar eye-safety problems would be apparent in a home use, self-care application of the devices described in each of the above-mentioned patents.
- The '49633 published application addresses the eye-safety issue by providing a diffusing unit. However, that device is far too bulky, complex and expensive for home use. The device includes a substantially non-portable laser floor unit and an extensible handpiece connected by a long beam delivery light guide. In addition, other safety issues exist for this device. For example, a home use, self-care setting may not be equipped to handle the electrical safety issues of a device that draws high current from a wall outlet. Most importantly, however, the invention described in the application addresses enhanced eye safety from a collimated laser beam, convergent laser beam, concentrated multiple laser beams or a fiber guided beam, and from monochromatic sources. In contrast, divergent light sources can be rendered eye safe substantially more easily, as described below in accordance with the present invention.
- The '029 and '020 patents describe devices that provide fluences over 100 J/cm2. These fluences are generally too large to be eye-safe and epidermis-safe in use in a self-care setting. Such output fluences are likely to give rise to fluences at the cornea potentially above the Maximum Permissible Exposure (MPE), described in more detail below, and/or may likely cause burning of the epidermal region of the treated skin. Moreover, such fluence levels are not efficiently produced in a self-contained apparatus, such as a hand-held and battery-powered device as is desired for self-care and home use in accordance with an embodiment of the present invention.
- Furthermore, the device described in the '029 and '020 patents provides a very small spot size between 2 and 5 millimeters in diameter corresponding to approximately 0.03 to 0.2 square centimeters in area. Such a small spot implies that only one hair is treated at a time, and in fact some sort of visual targeting is almost certainly required to ensure that the spot is indeed over even a single target follicle. Also, a small spot size such as between 0.03 and 0.2 square centimeters implies a very low coverage rate. That is, for a given number of square centimeters of skin containing unwanted hairs to be treated, the smaller the spot size the longer the necessary treatment time. In addition, while a small spot size would appear to be quite advantageous in that a low energy can still generate a high fluence on the skin surface (since fluence is energy divided by area), the fluence at some depth within the skin, e.g., where the target cells are located, is substantially reduced by scattering within the skin. That is, the smaller the spot size, especially below about 0.5 cm2, the more pronounced the effective lessening of fluence at depth relative to fluence at the surface. In short, if one goes to too small a spot such as is described in the '029 and '020 patents, the end result can be either burning of the epidermis (to get enough fluence in the dermis) or very poor efficacy due to inadequate fluence at depth; either of these options is obviously undesirable.
- The current state of the art of light-based epilation is well described by considering the two general types of devices on the market. One market segment encompasses devices designed and sold to physicians. Representative products include the LightSheer diode laser system now manufactured by Lumenis Ltd., the SLP-1000 fiber-coupled diode laser by Palomar Medical Technologies Inc., the Quantum flash lamp system manufactured by Lumenis Ltd., and the CoolGlide Excel YAG laser by Altus Inc. The physician devices are characterized by (a) established efficacy as confirmed by FDA clearance, (b) practical coverage rate, (c) high cost, and (d) relatively large size having a physical design where a handpiece is attached to a console, and (e) output fluences representing a severe eye hazard. These devices provide efficacious and practical light-based epilation and generally involve a peak optical power greater than 50 W, output fluence of greater than 10 J/cm2, spot size greater than 0.5 cm2, and a coverage rate greater than 10 cm2/min. Examples of these office-based devices are described in the patent literature cited above, and further examples may be found in other references cited herein.
- The other market segment comprises the limited number of consumer light-based epilation devices. It is believed that there are no personal light-based epilators currently on the market in the United States. At present, the most developed market for consumer light-based devices is Asia, and, in particular, Japan, where there are tens of products on the market. The devices by Ya-Man Ltd. of Tokyo are typical of the state of the art for these products in Japan. These consumer devices are characterized by (a) greatly reduced or no efficacy due to low peak power (.about.1 W or less) and small spot size (.about.0.1 cm2 or less), (b) slow coverage rate due to the small spot size and involving the targeting of individual hair follicles, (c) low cost, (d) relatively small size having a physical design where a handpiece is attached to a console or corded to a wall power supply, and (e) output fluences exceeding eye safety limits.
- The inventors of an embodiment of the present invention have recognized that a method and device that could provide effective and practical epilation in an entirely handheld and cordless device would be desirable. By cordless and handheld, it is preferably meant that the device is self-contained in operation, and has, for example, a volume less than 1500 cm3 and a weight less than 1 kg. Such a handheld and cordless device would be substantially less cumbersome than console and handpiece devices and allow the operator to much more conveniently position the device into orientations that are required to best treat a desired region of skin. In addition, it allows easy portability, and freedom to perform treatments in the absence of electricity from a wall outlet. In order to be an effective and practical treatment device, peak optical output powers greater than 10 W, output fluences greater than 4 J/cm2, spot sizes greater than 0.25 cm2, and coverage rates greater than 10 cm2/min may be generally involved.
- While other light sources for hair-regrowth inhibition, such as intense pulsed light, and a variety of lasers, are now commercially available to physicians, diode laser systems have proven to be among the most successful. These devices typically incorporate laser diode bars operating at a wavelength of approximately 800 nm. The systems range in peak optical power from about 90 watts to nearly 3,000 watts.
- Discrete laser diodes are limited in peak power to roughly one watt. While this low power may be adequate for treating individual hairs (such as the Ya-Man device manufactured in Japan), treatment of multiple hairs at a time for rapid treatment of extended areas requires peak optical powers of roughly 25 watts or more. Thus diode laser bars, rather than discrete diode laser devices, are incorporated into the diode-based office products named above. The success of these hair-regrowth inhibition systems incorporating laser diode bars, used by doctors and nurses in an office setting, has fueled interest in the development of home-use devices. The inconvenience of multiple visits to the doctor's office has also increased interest in devices that can be used safely and privately at home. Ideally, such a consumer device would be compact, inexpensive and battery powered, while incorporating proven laser diode bar technology. Unfortunately, because of the very high current requirement (.about.40 A) of laser diode bars, it is generally accepted that any such device could not be powered by batteries, but rather by an electrical cord to a wall outlet.
- Examples of other dermatologic devices are described at U.S. Pat. No. 6,533,775, and at U.S. published patent applications no. 2003/0004499 and 2002/0097587, and in other references incorporated by reference above and below herein.
- Although potentially eye-safe, the U.S. Pat. No. 6,533,775 patent describes a mechanical hair removal device, and not a light-based hair-regrowth-inhibition apparatus. The device described in the '775 patent includes a light source that reacts chemically with skin cream applied to the surface in order to reduce the onset time. The light produced by the mechanical hair removal device is not for effecting thermal damage of hair follicles to inhibit regrowth. The light is not designed to penetrate through the cream to create any thermal injury to targets within the dermis.
- The '97587 application describes a device with variable current control. This device is not designed for medical applications. The reference also does not provide any output fluences, wavelengths or pulse lengths that might by chance render the fluence at the eye of a person to be under the MPE. There would simply have to be many modifications made to this device to render it eye-safe for home use and to render it efficacious for dermatologic treatment for hair-regrowth inhibition.
- The '4499 application describes a device that is described as being designed to inhibit hair regrowth. The '4499 application refers to its procedure as bio-stimulation to produce bio-inhibition, and in any case, it is non-thermal. This is a wholly separate field from hair-regrowth-inhibiting devices that operate by causing thermal damage to hair follicles. The '4499 reference uses much lower fluences (or intensities) than would be efficacious for causing thermal damage to a hair follicle to produce hair-regrowth inhibition.
- The design of a handheld device for hair-regrowth inhibition requires clever circuit design, and implementation of a dermatologic treatment device that is efficacious and yet eye-safe requires novel optical design. Therefore it has appeared up to now that the creation of a low-cost, light-based dermatologic treatment device, such as a home-use hair-regrowth-inhibiting device that is effective, compact, battery-powered, and incorporates a diode laser or other light source, is an unachievable goal. However, recent advances in both light technology and microelectronics have made possible the present invention of dermatologic devices that are both efficacious and affordable to the average consumer. In some embodiments, these devices can be sufficiently compact as to be entirely handheld and battery-powered. In other embodiments, these devices can be made to be effective for a variety of dermatologic procedures, and yet eye-safe. They are the objects of the present invention, and are described in more detail below.
- Therefore in view of and in accordance with the above, a dermatologic treatment apparatus includes a one or more housings with at least one housing configured for manipulation in a dermatologic treatment procedure, a light source within at least one of the housings, and an electrical circuit. The circuit energizes the light source to produce output light pulses. A housing contains a light path from the light source to an aperture through which eye-safe light pulses are propagated out of at least one of the housings having properties sufficient for providing efficacious treatment. An optical diffuser is disposed along the light path to reduce the integrated radiance to an eye-safe level. The apparatus produces an output fluence not less than 4 J/cm2. In use, the dermatologic apparatus produces a fluence on the skin surface that is sufficient for efficacious treatment and has an integrated radiance insufficient to cause eye damage.
- In one aspect, the light source is a divergent light source. For example, the light source has a divergence that is greater than 1 degree, and is preferably greater than 6 degrees. In other aspects, the optical diffuser may be transmissive or reflective.
- A transmissive diffuser may include a bulk scattering diffuser medium such as opal glass, PTFE, thin Spectralon, or combinations thereof. The transmissive diffuser may also include a diffusive surface that is refractive or diffractive, or both, and may include a random surface such as ground glass, sandblasted glass or plastic, etched glass or plastic, or molded materials produced by a randomly textured mold, or combinations thereof. The transmissive diffuser may also include a patterned surface such as a holographic or Fresnel pattern. The reflective diffuser may include a rough surface such as sandblasted metal, plastic or ceramic, or etched metal, plastic, or ceramic, or molded materials produced by a rough mold, or combinations thereof, or may include a bulk diffuser or bulk diffuser coating, or both, such as comprising opal glass, Spectralon, PTFE, diffuse white coatings, Duraflect, or combinations thereof.
- A mixer may be disposed along the light path for distributing light more uniformly at the aperture. The principal optical axis of the light emitted by the source striking the diffuser is, in one embodiment, not parallel to the normal of the surface of the diffuser.
- In another aspect, the light source is a diode laser light source, a flashlamp source, or a light emitting diode (LED) source. In accordance with any of these aspects, the apparatus produces an output fluence between 4 J/cm2 and 100 J/cm2 wherein the fluence at the eye of a person is less than a maximum permissible exposure (MPE), such MPE having a value in J/cm2 equal to 1.8 10−3 t0.75 C4C6, where C4=1 for 400 nm to 700 nm light and C4=100.002(λ-700) for infrared wavelengths λ in nm from 700 nm to 1050 nm and C4=5 for 1050 nm to 1100 nm light, and C6 is a number between 1 and 66.7 for a diffuse source, and t is the pulse duration in seconds. The majority of the energy of a light pulse is contained within the spectral band of 700 nm to 1100 nm. The light pulses are emitted at a pulse repetition frequency between 0.1 Hz and 2 Hz, have pulse durations between 10 milliseconds and 1 second, have a peak power between 10 watts and 120 watts, and produce a spot size between 0.25 cm2 and 5 cm2.
- The dermatologic treatment procedure may involve photorejuvenation. In this case, the light source is preferably a flashlamp light source. At least a majority of the energy of the output light pulses emitted by the light source is between 500 nm and 1100 nm.
- The dermatologic treatment apparatus may be configured for performing at least temporary hair-regrowth inhibition, for treating acne, for treating benign pigmented lesions, for vascular treatment, and/or for skin texture or wrinkle treatment, or both.
- A dermatologic treatment method is also provided for treating a person's skin. The method may be used in any of the procedures mentioned, and may utilize an apparatus according to any of the above aspects that are not repeated here. A handpiece assembly of a dermatologic treatment device is gripped in a person's hand. The handpiece assembly is positioned such that an output window component of the device contacts a region of the epidermis of a same or different person. A light source is energized with an electrical circuit to produce output light pulses. The light pulses generated by the light source are transmitted along a light path including an aperture through which eye-safe light pulses are propagated from the handpiece having properties sufficient for efficacious treatment including producing an output fluence not less than 4 J/cm2. The light pulses are optically diffused along the light path to reduce the integrated radiance to an eye-safe level. Then, the device is manipulated in a skin treatment procedure that produces a fluence on the skin that is sufficient for efficacious treatment and yet has an integrated radiance insufficient to cause eye damage.
-
FIG. 1 schematically illustrates a dermatologic treatment apparatus in accordance with a first embodiment that is self-contained and battery-powered. -
FIG. 2A schematically illustrates a dermatologic treatment apparatus in accordance with a second embodiment in contact with a person's skin, that is eye-safe and that incorporates a transmissive diffuser. -
FIG. 2B schematically illustrates a dermatologic treatment apparatus in accordance with a third embodiment in contact with a person's skin, that is eye-safe and that incorporates a reflective diffuser. -
FIGS. 3A and 3B schematically illustrate an optical diffuser in accordance with the second embodiment. -
FIG. 3C schematically illustrates an optical diffuser in accordance with the third embodiment. -
FIG. 3D schematically illustrates yet another type of optical diffuser that has a spatially uniform output. -
FIG. 3E schematically illustrates the optical diffuser ofFIG. 3C in contact with a person's skin during a hair-regrowth-inhibiting procedure or other dermatologic procedure. -
FIG. 4 schematically illustrates the divergence of a laser beam transmitted through a biconcave lens. -
FIG. 5 schematically illustrates a hair-regrowth-inhibiting apparatus in accordance with the second embodiment. -
FIG. 6 schematically illustrates a front perspective view of a self-contained housing of a hair-regrowth-inhibiting apparatus in accordance with a preferred embodiment. -
FIG. 7 schematically illustrates a rear perspective view of the self-contained housing of the hair-regrowth-inhibiting apparatus ofFIG. 6 . -
FIG. 8 schematically illustrates indicator lights of the hair-regrowth-inhibiting apparatus ofFIGS. 6-7 . -
FIG. 9 schematically illustrates a perspective view of an AlGaAs laser diode bar. -
FIG. 10 schematically illustrates a cross-sectional view of a hair-regrowth-inhibiting apparatus in accordance with the second embodiment. -
FIG. 11 schematically illustrates components of an electrical circuit in accordance with a preferred embodiment. -
FIG. 12 schematically illustrate components of an electrical circuit for powering a laser diode light source with batteries through a FET-based switch in accordance with a preferred embodiment. - What follows is a list of citations corresponding to references which are, in addition to those references cited above and below, and including that which is described as background and the invention summary, hereby incorporated by reference into the detailed description of the preferred embodiments below, as disclosing alternative embodiments of elements or features of the preferred embodiments that may not otherwise be set forth in detail below. A single one or a combination of two or more of these references may be consulted to obtain a variation of the elements or features of preferred embodiments described in the detailed description below. Further patent, patent application and non-patent references are cited in the written description and are also incorporated by reference into the preferred embodiment with the same effect as just described with respect to the following references:
- U.S. Pat. Nos. 4,232,678, 4,551,628, 4,592,353, 4,690,141, 5,057,104, 5,059,192, 5,075,971, 5,109,465, 5,401,270, 5,405,368, 5,431,647, 5,486,172, 5,700,240, 5,728,090, 5,743,901, 5,820,625, 5,824,023, 5,871,521, 5,885,273, 6,059,765, 6,096,029, 6,138,041, 6,160,831, 6,188,495, 6,197,020, 6,228,074, 6,273,884, 6,277,111, 6,280,438, 6,290,713, 6,440,122, 6,441,943, 6,508,813, 6,511,475, 6,514,242, 6,516,013, 6,517,532, 6,533,775, 6,548,781, 6,563,853 and 6,641,044; United States published applications no. 2003/0233138, 2003/0032950, 2003/0004499, 2002/0128635, 2002/0097587, 2002/0091377, 20020015430, and 2002/0005475; and
- U.S. provisional patent applications No. 60/451,091, filed Feb. 28, 2003; 60/456,379, filed Mar. 20, 2003; 60/458,861, filed Mar. 27, 2003; 60/472,056, filed May 20, 2003; 60/450,243, filed Feb. 25, 2003; 60/450,598, filed Feb. 26, 2003; 60/452,304, filed Mar. 4, 2003; 60/451,981, filed Mar. 4, 2003; 60/452,591, filed Mar. 6, 2003; and 60/456,586, filed Mar. 21, 2003; and
- Published PCT applications no. WO 03/049633;
- European published application no.
EP 1 168 535,EP 0 761 257,EP 1 116 476 and -
EP 0 933 096; French patent document no. FR2665366; - Japanese patent documents no. JP2000300683, and JP11244295;
- German patent document no. DE19629978; and
- Sliney, et al., Safety with Lasers and Other Optical Sources, A Comprehensive Handbook, Plenum Press (1980); and
- Hode, L, “Are lasers more dangerous than IPL instruments?” Lasers in Surgery and Medicine, Supplement 15, 2003, p. 6; and poster presentation at corresponding conference.
- A device and method are described in a first embodiment that enable light-based dermatologic treatment with a self-contained and handheld device. The device embodies an advantageous combination of a battery-powered electrical circuit design, a self-contained housing mechanical design, and a light source and optical design, that enables efficacious and practical dermatologic treatment in a cordless and handheld manner.
- The light source may be, for example, one or more semiconductor laser diode bars that generate pulses of infrared light. To effect hair-regrowth inhibition, light from the device passes through the epidermis and is absorbed by melanin in the hair shaft and follicle. The resulting brief temperature rise of the follicle temporarily disables it, delaying the regrowth of hair. The device can be pulsed at a repetition rate of up to 0.5 Hz.
- Effective dermatologic treatment, e.g., hair-regrowth inhibition, can occur with standard (10-40 J/cm2) output fluences, yet with very long pulse durations (up to 1000 ms). This avoids the need for very high peak laser powers; for example, to produce 20 J/cm2 in 350 ms with a 9 mm by 9 mm output area requires a optical peak power of only 46 watts. The modest peak power requirement, in turn, reduces the electrical pulsed power requirement, and thereby permits battery operation. Through the use of miniature surface-mount electronic components, thermo-electric (TE) modules and advanced nickel-metal-hydride battery technology, such a device has been invented that may be entirely handheld, with the aforementioned parameters in a preferred embodiment.
- A device in accordance with a preferred first embodiment is illustrated schematically in
FIG. 1 . The elements shown arelight source 10,mixer 12,output window 14, heat-removal element 16,electrical battery 18, andhousing 20. Not shown but involved in the operation of the device are other mechanical, electrical, and optical elements (such as a trigger, drive and control circuitry, sensors, and indicators) such as may be described in more detail below and/or as may be understood by those skilled in the art. That is,FIG. 1 is intended merely to serve to introduce the device of a preferred first embodiment to be described in more detail below. - In operation, the user charges the electrical battery 18 (by placing the device in a charging station, for example, that will provide electrical charge from a wall outlet). Once charged, the user presses an
output window 14 oraperture 14 against the surface of the skin to be treated. The aperture orwindow 14 in contact with the skin is preferably made of sapphire, because of its relatively high thermal conductivity. The output aperture orwindow 14 may, however, be only an opening or aperture such that thewindow component 14 that contacts the person's skin may be a frame of the opening. The heat-removal element 16 draws waste heat fromlight source 10 and may draw heat as well from the skin by conduction throughwindow 14 andmixer 12. The heat-removal element 16 may be a thermoelectric heat exchanger that dissipates heat to the surrounding air by use of a finned heat sink and fan; or may be a solid material that acts as a heat sink due to its high heat capacity (a “thermal battery”) as described in some further detail below. The user then activates a pulse from thelight source 10 by pressing a trigger button. In an alternative embodiment, the electrical circuit may be designed so that upon sufficiently contacting the skin of a person being treated, a contact sensor located near the output aperture senses sufficient contact of theoutput window component 14 with a person's skin so that one or more pulses may be automatically activated. The light pulse enters themixer 12 which serves to distribute the light substantially uniformly onto theoutput window 14 and ultimately into the skin. Theoutput window 14 is connected to the heat-removal element 16 bymixer 12 and thus additionally serves as a protective heat sink for the skin. - To further simplify operation, the preferred device operates at a fixed, mid-range output fluence setting of nominally 20 J/cm2 and a fixed, mid-range pulse duration of nominally 300-350 ms. In an alternative embodiment, the output fluence would be continuously or discretely adjustable. Details of the electrical circuit design are provided below.
- Additional details of a preferred embodiment of a light-based hair-regrowth-inhibition apparatus are shown in
FIGS. 6-8 . The exterior of theunit housing 410 is shown schematically in these figures.FIG. 6 illustrates a perspective front view and theoutput window 420 is shown.Trigger buttons 430 for initiating laser pulses are also shown and are easily depressed by a left- or right-handed self-care user. Vent louvers oropenings 440 are also visible. A chargingbase 450 is shown with a power cord 460 for recharging the apparatus. - In the rear perspective view of the apparatus shown in
FIG. 7 , theoutput window 420 is indicated along with thevent louvers 440, as well as an on-off button 460 and indicator lights 470. The indicator lights 470 are illustrated in more detail inFIG. 8 . Abattery charge indicator 472, an on/offindicator 474 and aready indicator 476 are provided examples. - The primary elements of the apparatus will preferably have a volume less than approximately 2000 cm3, and more preferably less than approximately 1000 cm3, and a weight less than approximately one kilogram. Even more preferably, the apparatus may have a volume less than 700 cm3 and a weight less than 700 grams. In this way, the apparatus can be gripped and firmly controlled in a self-care procedure within a user's hand without providing stress in the user's grip and without causing excessive fatigue during use. As illustrated in
FIGS. 6-7 , the apparatus has a volume of 400 cm3 and a weight of 500 g in a cordless, self-contained device. It is noted that where the term cordless is used herein, it is meant to refer to a unit that is battery-powered and not electrically plugged into an external outlet or power source during use. In addition, where the term self-contained is used herein, it is meant that the unit is not physically connected to a base unit or other such unit and is free to be manipulated without attached wires or couplings. In that sense, a self-containedhousing 410 such as that illustrated inFIGS. 6-7 has the light source and batteries contained within it, such that the housing is not attached to any electrical cable or light guide cable that protrudes out of thehousing 410. This is not to say that a wireless control, or other wireless coupling, or the chargingbase 450 cannot be included components of a unit that includes the preferred self-containedhousing 410 illustrated inFIGS. 6-7 ; however in use, thehousing 410 is free of externally protruding physical couplings such as control wires, optical cables and power cords. - Even allowing for maximum electrical, thermal, and optical inefficiencies, control circuitry, and mechanical packing factors, the handheld device of the preferred embodiment is highly efficient, self-contained and user friendly. Furthermore, the output parameters of the device establish that it is efficacious and practical in use.
- In this section, additional details are provided regarding a preferred method of use of the apparatus. Charging the apparatus involves its placement into a charging
base 450 shown inFIG. 6 generally overnight prior to use. Charging of the device is easily done by plugging the power cord into a suitable AC outlet and placing the device into the chargingstand 450. Following use, the unit should be returned to thecharger 450, so that it will be fully charged for the next use. The unit may be left in thecharger 450 for extended periods of time without harm to the unit. - During charging, the left indicator light 472 (
FIGS. 7-8 ) flashes green. When the battery is fully charged, this light will cease flashing and remain green. - Preparing the skin for maximum comfort during use involves shaving the area to be treated prior to treatment, and then wiping with a cool, damp cloth. Because the unit relies on absorption of light by the hair shaft under the skin, the hair should not have been previously removed by plucking or waxing. If either of these methods were performed recently on the area to be treated, treatment should be postponed until hairs are once again visible.
- Performing the treatment, after the unit has been fully charged, involves turning on the unit by pressing and releasing the ON-OFF button 460 shown in
FIG. 7 . When the unit is on, the center indicator light 474 shown inFIG. 8 will illuminate. - For a brief period after the power is turned on, the
right indicator light 476 may flash, indicating that the unit is approaching the “ready” state. Theright indicator light 476, when steadily green, indicates that the device is ready and will emit a light pulse when either of the twotrigger buttons 430 is depressed (provided that theoutput window 420 is in contact with skin). Two triggers 430 are provided to permit comfortable use of the device in either hand. - To perform the treatment, the
output window 420 is placed firmly against the shaved skin area to be treated, and either trigger 430 pressed and released. A beep will be preferably heard when the laser pulse is completed. In a particular embodiment, a beep and/or other tone or sensory indication is preferably heard when good contact is made within the skin indicating that the contact sensors around thewindow 420 are in contact with the skin and will permit the pulse to be propagated out of thehousing 410. Accordingly, the self-care user will know that the unit will not generate a pulse until good contact is established and the tone is heard. In another embodiment, a beep and/or other tone or sensory indication will be heard if after making good contact with the user's skin, theoutput window 420 is moved away from good contact. This indication is to inform the user that a pulse will not be permitted to be propagated from thehousing 410 until good contact is re-established. After the pulse-completed beep is heard, theoutput window 420 is moved to an adjacent area, allowing for approximately fifty-percent overlap. That is, the tip should be moved a distance about one-half the width of the area contacting the skin. It is not necessary to hold the trigger down throughout the pulse. It is, however, important to maintain full contact between the skin and theoutput window 420 for the entire duration of the laser pulse. If theoutput window 420 is lifted from the skin prior to completion of the laser pulse, a distinct tone is sounded to alert the user, and the area should be re-treated with an additional pulse. - The preferred maximum repetition rate of the unit is one pulse every two seconds, and generally between one pulse every second and one pulse every four seconds. Thus there may be a few-seconds delay before the next beep is heard.
- All of the various sounds described above serve as audible feedback and aid in the use of the device.
- Alternative embodiments of a dermatologic treatment device and method incorporate an optical diffuser, described in detail below, to greatly enhance the eye safety of the device while minimally affecting efficacy. The addition of an optical diffuser to increase the divergence and to reduce the spatial coherence of the light emitted from the device allows the apparatus to be classified as a Class I Laser Device under the guidelines of the U.S. Food and Drug Administration Center for Devices and Radiological Health. This permits the use of the apparatus without having to wear laser safety glasses or goggles, and most importantly, eliminates the risk of eye injury if other safety means such as the contact sensor described above should fail.
- Accordingly, a device and method for dermatologic treatment are provided in a second and third embodiment that are inherently eye-safe. That is, the device and method are effective in treating various dermatologic conditions (i.e. produce a fluence at the skin surface of greater than about one joule per square centimeter) and yet at the same time, when aimed directly into the eye from any distance, produce a fluence at the human eye that is below the Maximum Permissible Exposure (MPE) as defined by the American National Standards Institute (ANSI) and the International Electrotechnical Commission (IEC). This value for the MPE is essentially the same as the Exposure Limit (EL) published by the International Commission on Non-ionizing Radiation Protection (ICNIRP).
- It is recognized in the design of the apparatus that, unlike many applications for lasers and other light sources, dermatologic treatment does not generally require a highly directed beam. As long as the light is confined in some manner within a handpiece or applicator prior to its entering the skin surface, there is very little value in requiring the light to strike the skin at normal incidence (i.e., light rays oriented roughly perpendicular to the skin surface). This is because the skin is a highly scattering medium, and any light rays entering the skin at normal incidence are scattered by epidermal skin cells very near the surface and thus are redirected into all angles. The incorporation of a diffuser accomplishes this spreading of the light rays prior to entering the skin, which has little impact on efficacy but greatly enhances eye safety. It should be noted that simply increasing the divergence of a coherent source such as a laser by inclusion of a simple diverging element (e.g., a lens) is not nearly sufficient to achieve the requisite eye safety, due to the focusing ability of the eye and resulting intensification of that light onto the retina.
- It is noted that the devices described in the second and third embodiments below can readily accommodate the essential elements of the first embodiment. That is, the eye-safe devices described in the embodiments below could be realized in a self-contained, battery-powered device. Alternatively, the devices described below could be corded to operate from a conventional wall outlet during use. It is also noted that the method of use of the devices described in the second and third embodiments is essentially the same as that described in the first embodiment.
-
FIG. 2A schematically illustrates a dermatologic device, such as a light-based hair-regrowth-inhibition device, incorporating a transmissive diffuser in accordance with the second embodiment of the invention. When used herein, a transmissive diffuser is intended to describe an element incorporated into a light path having an input surface which the light initially strikes; and a second, output surface from which light propagates. Such input and output surfaces of the transmissive diffuser are separated by the material of the diffuser itself. - The figure schematically illustrates the device, in contact with
skin 150, that incorporates the use of a diffusingmaterial 120 through which the light passes before leaving the apparatus though output window (or simply an open aperture) 100. Contained within thesource chamber 130 is alight source 140 that emits pulses having many advantageous features.Light source 140 may be, for example, a laser diode assembly for treatment of a dermatological condition, and preferably includes one or two laser diode bars. - The diffusing
material 120 is placed over an aperture insource chamber 130.Light source 140 preferably does, but need not, uniformly illuminatediffuser 120. Thediffuser 120 is designed to increase the divergence of the light emitted fromlight source 140, and to reduce the spatial coherence of the light source.Diffuser 120 may be made of a material that scatters light traveling through it, such as an opalized glass substrate. Details regarding appropriate optical diffuser designs and materials are contained in a subsequent section describing component details. In a variation of this embodiment, the inner walls of thesource chamber 130 would be coated and/or otherwise constructed of a material that is non-absorbing at the therapeutic wavelengths emitted bysource 140. A source chamber that is not substantially non-absorbing would also be acceptable; however, a more intenselight source 140 would be involved for the same power delivered to the skin. The requirement for additional power is not desirable, particularly in a cordless, hand-held, self-care device because energy efficiency is at a premium. - The spatial uniformity of the light may be increased through the use of a mixing
chamber 110 which may be simply a hollow tube with substantially non-absorbing side walls through which the light would propagate prior to leaving the apparatus throughoutput window 100. If the spatial uniformity of the light at the diffuser is adequate for the desired treatment, the mixer can be omitted, so that thediffuser 120 may even be in contact with the skin and serve as the output window. Alternatively, thediffuser 120 may be located at the position shown inFIG. 2A even if it is determined that sufficient uniformity may be achieved without the function of the mixingchamber 110. It is desired, however, that thediffuser 120 not be placed so close to thelight source 140 that substantial non-uniformity results from the light not having sufficiently diverged from the light source before impinging upon thediffuser 120. -
FIG. 2B schematically illustrates a dermatologic device, such as a light-based hair-regrowth-inhibition device, incorporating a reflective diffuser in accordance with the third embodiment of the invention. By reference toFIG. 2B , the term reflective diffuser is intended to describe an element incorporated into a light path having a first or input surface which the light initially strikes; however, in contrast to a transmissive diffuser, this first surface also serves as the output surface from which light propagates from the diffuser. It is further noted that the term “reflective” is used in this context to include remitted light. That is, the diffuser may scatter or refract light as well. - In
FIG. 2B , a light-based hair-regrowth-inhibition device is illustrated in contact withskin 155 that incorporates the use of a diffusingmaterial 125 which diffuses light from source orsources 145 before the light leaves the apparatus though output window (or simply an open aperture) 105. Contained within thechamber 115 is a light source orsources 145 that emit pulses having many advantageous features. Light source orsources 145 may be, for example, laser diode bars for treatment of a dermatological condition such as unwanted hair. - The diffusing
material 125 is placed withinchamber 115 in a position generally opposite the skin, as shown. Light source orsources 145 preferably does, but need not, uniformly illuminatediffuser 125. Thediffuser 125 is designed to increase the divergence of the light emitted from light source orsources 145 and to reduce the spatial coherence of the light source or sources.Diffuser 125 may be constructed of a highly scattering material such as PTFE, e.g., Teflon. Details regarding appropriate optical diffuser designs and materials are contained in a subsequent section describing component details. In a variation of this embodiment, the inner walls of thechamber 115 would be coated and/or otherwise constructed of a material that is non-absorbing at the therapeutic wavelengths emitted by source or sources 145. The spatial uniformity of the light may be increased through the use ofchamber 115 as a mixer which may be simply a hollow tube with substantially non-absorbing side walls through which the light would propagate prior to leaving the apparatus throughoutput window 100. It is further noted thatFIG. 2B illustrates the concept of a reflective diffuser in an embodiment wherein light from the source orsources 145 is initially directed away from theskin 155, prior tostriking diffuser 125. The device inFIG. 2B could be alternatively constructed wherein light from source orsources 145 initially propagates in a direction toward the skin; but, prior to striking the skin, such light is redirected by a mirror or mirrors back toward thediffuser 125. - Light Source
- With reference to
FIG. 1 , thelight source 10 is preferably two diode laser bars at a nominal wavelength of approximately 800 nm. Operating specifications may be, for example, 20 J/cm2 output fluence, 350 ms pulse duration, 0.8 cm2 spot size (output aperture), and 0.5 Hz pulse repetition rate. These parameters correspond to an optical peak power of 46 W and a duty cycle of about 18%; the resulting average optical power is thus about 8 W. Diode bars operating at these parameters are about 35-40% efficient; thus the average electrical power into the light source is about 23 W (8 W of emitted average optical power and about 15 W of waste heat). The volume and weight of the light source is about 1 cm3 and 10 g. Alternative embodiments for the light source include use of one diode laser bar rather than two, use of more than two diode laser bars, use of light emitting diodes (LED's), and use of a flash lamp (also known as a flash tube) or arc lamp. - Skin Contact Sensor
- To prevent an inadvertent output light pulse from the device when it is not in contact with skin, a skin contact sensor is preferably incorporated into the tip of the preferred dermatologic treatment apparatus. The sensor may include a ring of very small “membrane switches” located around the circumference of the preferred sapphire window. The signals from the membrane switches prevent firing of the device unless it is in substantial contact with a contacted surface such as skin. In an alternative embodiment, the trigger may be eliminated, and the closing of one or more membrane switches may activate one or more light pulses. As described above, audible or other sensory indications are preferably provided when good contact is made, and when the output window is displaced from a good contact position on the user's skin such that firing is disabled until good contact is again established. An audible or other sensory indication is also preferably provided at the end of a pulse indication to provide feedback to the user that the apparatus may be moved to another location before the next pulse.
- Charging Base
- Between uses of the dermatologic treatment apparatus of the preferred embodiment, it is preferably placed in a charging base (see
FIG. 6 ). The charging base may be similar to those currently produced for use with electric toothbrushes, shavers, phones, etc. The base is connected to a standard AC outlet, and is capable of recharging the batteries overnight. - As mentioned above, the apparatus in the second or third embodiment may also be corded to operate from a standard wall outlet during use, eliminating the need for a charging base.
- Mixer
- In the embodiment shown in
FIG. 1 , themixer 12 serves to (a) to mix the light emitted from the diode lasers to produce a uniform beam profile at theoutput window 14, (b) to provide a low thermal resistance path between theoutput window 14 and the heat-removal element 16, and (c) to minimize thermal loads on the device that are due to light absorption from back-reflected or back-scattered light. - The
mixer 12 comprises a hollow chamber where the wall material is either copper or aluminum. The walls are either the polished substrate or coated to achieve high reflectivity to 800 nm light. The length of the mixer is designed to provide good spatial uniformity of light on a 1.times.1 cm output window from two diode bars spaced 6 mm apart. The wall thickness of the mixer is designed to provide good thermal conductivity between theoutput window 14 andheat removal element 16. For copper walls surrounding a 1.times.1 cm output window, a wall thickness of about 2 mm is required to conduct about 8 W of average power to athermal source 2 cm away with a 5 degree C. temperature rise. The volume and weight of the mixer is about 4 cm3 and 20 g. The thermal load on the mixer due to light absorption is less than 1 W. An alternative embodiment of themixer 12 might include various shapes and may comprise multiple elements to achieve the thermal link between the output window and the heat removal element and to achieve light mixing and low light absorption. The cross-sectional shape may be any of a variety of shapes (such as circular or rectangular) and may vary along the length of the mixer. Because the skin, or the diffuser, or the walls of the mixer may remit light in a direction away from the skin, the mixer may comprise not only low-absorbing side walls, but also a low-absorbing surface opposite the output aperture. Such low-absorbing surface may contain one or more openings through which light from the light source passes, or may simply constitute the surface adjacent to the light source. - In an alternative embodiment, the mixer may consist of an inner mixer, such as a sheet of polished metal, for the purpose of reflecting light from the light source toward the
output window 14; and a thicker metal outer surface, such as a copper or aluminum barrel, to conduct heat fromoutput window 14 to heat-removal element 16. In this embodiment, the inner mixer may alternatively be fabricated from a solid transparent material such as glass or acrylic. In this case the light from the light source would be reflected toward theoutput window 14 by total internal reflection within the glass or acrylic. - Optical Diffuser
- The term “diffuser” or “optical diffuser” refers throughout this patent application not only to conventional, commonly known elements such as the “optical disk diffuser” of the flashed opal type (e.g., Oriel Instruments Model 48010, Stratford, Conn.) but more generally to any element that, when incorporated into a light-emitting device having a given radiant exposure or fluence, greatly reduces the integrated radiance (“brightness”) of the device. A diffuser generally increases the divergence and reduces the spatial coherence of light incident upon it.
- With reference to
FIG. 2A ,diffuser 120 may be made of a material that scatters light as it travels through it such the abovementioned optical disk diffuser from Oriel. Alternatively,diffuser 120 may be a transparent substrate whose surface has been roughened so as to scatter the incident light through refraction.Diffuser 120 may be a bulk scattering diffuser, made for example from opal glass, PTFE, a thin (e.g. 0.5 mm) sheet of Spectralon, or combinations thereof. Thediffuser 120 may alternatively have a refractive or diffractive surface or body; or have a diffusing surface comprising random surface irregularities. Such diffusers may be made of ground glass, sandblasted glass or plastic, or molded materials produced by a randomly textured mold, or combinations thereof. Alternatively,diffuser 120 may have a patterned surface or body, for example with a holographic or Fresnel pattern. - The
reflective diffuser 125 as shown inFIG. 2B may be constructed of a highly scattering material such as PTFE, or a commercial material such as Spectralon (available from LabSphere, Inc.). Alternatively,diffuser 125 may comprise a scattering material such as Duraflect (also available from LabSphere, Inc.) applied to the surface of thechamber 115 opposite theskin 155. Alternatively,diffuser 125 may be fabricated simply by roughening the surface ofchamber 115 opposite theskin 155; however, the preferred embodiment would incorporate an actual diffusing material such as Spectralon, or an applied surface coating such as Duraflect, due to the low absorption of these materials. Alternatively,diffuser 125 may be made of a material that scatters light as it travels through it such as an opalized glass substrate, e.g., part #48010 manufactured by Spectra-Physics (Oriel), and then backed by a highly reflective mirror; in this way a transmissive diffuser material can be made to serve as a reflective diffuser. -
FIG. 3A illustrates an example of adiffuser 120 including transparent screens of the fine-structure or lenticular types.FIG. 3A illustrates transmissive sheets having molded or machined refractive or diffractive elements. Thediffuser 120 may also include zones of concentric microgrooves, as illustrated atFIG. 3B . - The
diffuser 125 ofFIG. 2B may include merely roughened interior surfaces of a passageway through which light is scattered prior to exiting the device, such as illustrated atFIG. 3C , discussed in reference toFIG. 3E in more detail below. - Yet another means of achieving very low integrated radiance for a given output fluence from a device in accordance with embodiments of the invention includes a small light source approximating a “point source” projecting into a mixer having mirrored walls such as that illustrated at
FIG. 3D . -
FIG. 3E shows an embodiment of the current invention in contact withskin 250 that incorporates the use of the diffusingsurface 220 ofFIG. 3C which the light strikes before leaving the apparatus thoughoutput window 200. Again,light source 240 is housed withinsource chamber 230. However, instead of a diffusing material through which the light passes prior to leaving the device, a diffusingsurface 220 is positioned relative to source 240 such that the light strikessurface 220 prior to leaving the device. Diffusingsurface 220 may be merely a roughened surface such as sand-blasted aluminum designed to diffuse the light, or diffusingsurface 220 may be a surface coated with a bulk diffuser such as an opalized material used in part #48010 manufactured by Spectra-Physics (Oriel).Surface 220 need not coat the entire inner wall ofsource chamber 230 but only a sufficient portion to achieve a desired level of beam divergence and reduced spatial coherence. A preferred embodiment would use a material forsurface 220 that is substantially non-absorbing at the therapeutic wavelengths emitted bysource 240. - Other designs are possible as understood by those skilled in the art and as provided in the literature incorporated by reference herein, i.e., these are merely examples.
- Output Window
- The
output window 14 is preferably a transparent, high heat capacity and high thermal diffusivity material, such as sapphire, with a low thermal resistance connection to themixer 12. A thickness of 5 mm provides acceptable heat sinking capability for a 1.times.1 cm sapphire window. The volume and weight of theoutput window 14 is about 0.5 cm3 and 2 g. The thermal load on the output window is about 8-9 W of average power. - Heat Removal Element
- The heat-
removal element 16 could be a thermal battery made of a high heat-capacity single-phase material, such as copper, water, or aluminum, or could be any of a variety of phase-change materials such as salt hydrates and paraffin waxes, which can provide 5-10 times greater thermal energy density and thus provide for a more compact thermal battery. An embodiment with the thermal battery material TEAP/Climator ClimSel 24 can store 210 J/cm3 and 144 kJ/kg over a 10 degree C. working range. Thus, for a 10 minute treatment at 23 W of average heat load the thermal battery would be about 70 cm3 and 100 g. - Alternative embodiments of the heat-
removal element 16 include a thermoelectric-based heat exchanger. The heat exchanger would have a cold-side heat sink thermally connected to the rest of the device, a thermoelectric module, and a hot-side heat sink thermally connected to the environment. A fan to provide forced convection may be part of this heat exchanger. - A semi-schematic cross-sectional drawing of an apparatus in accordance with a preferred second embodiment is shown in
FIG. 10 . Mounted at the end ofdevice housing 610, which also serves as a handle, is the laser head of the device, containing preferably two AlGaAs laser diode bars mounted on a fan-cooled, finned heat sink. The laser light propagates through a square tube having a cross-section of 9 mm by 9 mm, through an opal-glass diffuser andsapphire window pair 626. The sapphire window, which is in contact with the skin during treatment, is held near room temperature by small thermoelectric modules mounted on either side of the diode bars. - A typical
diode laser bar 500 includingmultiple diode emitters 510, such as that illustrated atFIG. 9 (and such as may be manufactured by Spectra-Physics, Inc., of Mountain View, Calif., or Coherent, Inc., of Santa Clara, Calif.), has a continuous optical power output of 20-40 watts, and a maximum peak power output approaching 100 watts. For this reason, a hair-regrowth-inhibition device with an output optical peak power of over 25 W can be designed with only one or twobars 500, rather than 25 or more discrete laser diodes. Eachlaser diode bar 500 has manyindividual emitters 510 preferably fabricated on a monolithic structure, and requires roughly 40 amperes of current at a voltage of slightly under 2.0 volts to produce 30 watts of optical peak power output for more than 50 milliseconds. -
Device housing 610 containsbattery pack 710 consisting of, for example, six nickel-cadmium or nickel-metal-hydride 1.2 V “C size” batteries (e.g., Panasonic part no. P-170SCW, or HHR300SCP).Housing 610 also enclosescircuit board 614 containing the control electronics, described in detail below. Electrical power from thebattery pack 710 is conditioned and controlled by electronics oncircuit board 614, and current of nominally 40 A is conducted through wires (not shown) to laser diode bars 720 mounted on heat sink 618 (e.g., laser diode bar packages, part no. ASM06C040W080810B80, Cutting Edge Optronics). -
Heat sink 618 is attached to finned heat sink 620 (e.g., part no. HX8-101, Melcor, Trenton, N.J.), and cooled by fan 622 (e.g., part no. FAN-101 from Melcor) which is also powered by thebattery pack 710.Heat sink 618 is preferably a good thermal conductor and an electrical insulator. The material BeO is preferably used for theheat sink 618. Thefinned heat sink 620 may comprise a block of aluminum or copper or other material of high thermal conductivity. Thefinned heat sink 620 exchanges heat with the air which is circulated byfan 622. Laser light from laser diode bars 720 passes through mixer 624 (for example, a hollow tube of square cross-section having highly reflective walls, such as gold-plated aluminum). - Light from
mixer 624 then passes through diffuser/window 626, preferably of opalized glass (e.g., part no. W13.50 from Swiss Jewel) and sapphire, and subsequently passes into the person'sskin 628 containing one or more unwanted hairs. Diffuser/window 626 is prevented from overheating by allowing excess heat from diffuser/window 626 to be conducted throughmixer 624 to the cold side of thermoelectric (TE) cooling modules 630 (e.g., Melcor part no. CP 0.8-31-06L).TE modules 630 are in turn cooled by placement of their hot side againstheat sink 620.TE modules 630 are preferably solid-state devices that pump heat frommixer 624 to theheat sink 620. - The principal optical axis of the laser diode bars may be aligned with the principal optical axis of the mixer and parallel to the normal to the surface of the diffuser/
window 626, as shown inFIG. 10 . In an advantageous embodiment, however, the principal optical axis of the light emitted from the laser diode bars is not substantially parallel to the normal of the surface of the diffuser. This may be accomplished by tilting the principal optical axis of the laser diode bars so that they are not parallel to the normal of the surface of the output window; or by mounting the diode bars so that their principal optical axis is parallel to the normal of the surface of the diffuser, but the light emitted from such bars strikes the diffuser at a different angle through the use of a mirror or mirrors. The angle is preferably around 45 degrees. This embodiment permits the light generated by the laser diode bars 720 to already be spreading outward from the forward direction prior to striking the diffuser/window 626, resulting in an even more diffused and eye-safe beam propagated from thehousing 410. - Laser Diode Circuit Overview
- An apparatus and method is described for dermatologic treatment in an embodiment that utilizes battery-powered laser diode bars. The apparatus comprises a hand-held treatment device for dermatologic use, one or more batteries, one or more laser diode bars, and an electronic control circuit. The apparatus enables, for the first time, effective home hair-regrowth inhibition, in a device significantly above the 1 W optical output level that is compact, affordable (less than $1,000) and is free of cords and/or other connections to an electrical outlet. The device incorporates a small number of batteries (preferably three to six), an efficient circuit design that effectively draws 40 amperes or more from the batteries, and typically contains one or two laser diode bars producing a combined optical peak power output of 10-120 W, or more preferably 30-60 W, at 800 nm. With this apparatus, the consumer can inhibit hair regrowth in the privacy of the home using a device that has an output power much higher than existing home “hair removal” devices (enabling more effective hair-regrowth inhibition and a faster coverage rate) while also enjoying the convenience of compact device size and cordless (battery-powered) operation. The device may also be suited for use while plugged in, e.g., when it is not inconvenient to utilize the device while it is attached to an outlet or other source of electrical power. This can save battery power at times and can also serve to recharge the batteries.
- The concept is not limited in its advantageous application to hair-regrowth inhibition, nor to the preferred wavelength of approximately 800 nm; but rather, may be applied more broadly to dermatologic treatment utilizing battery-powered laser diode bars for other applications, and/or other wavelengths. For example, benign pigmented lesions and unwanted leg veins may be treated by dermatologists in an office setting using an 800-nm laser diode bar source; and treatment of acne by destruction of the sebaceous gland is possible utilizing a similar laser diode bar source at 1400 or 1700 nm (both absorption peaks of sebum). The invention is also not limited to devices containing only one or two laser diode bars each containing multiple laser diode emitters, but may include a different number of laser diode bars and may include other alternative light sources such as solid-state lasers, semiconductor lasers, VCSEL's and flashlamps, among others that may be understood to those skilled in the art that generally meet the input and output criteria described herein for a battery-powered, home care device.
- An apparatus and method in accordance with a preferred embodiment include increased eye safety by increasing the divergence and reducing the spatial coherence of the light emitted from the output aperture of the dermatological apparatus. It is noted that the output aperture may be a clipping aperture, but as used herein, is not so limited, and the term is meant to include any plane through which the light travels or transmits, and may comprise a particular solid material such as a window or optical diffuser or a fluid such as air.
- The apparatus and method may alternatively involve operation from a conventional wall outlet, eliminating the need for batteries.
- Overview of Batteries and Control Electronics
- Although a transformer can in principle be used to increase the 0.001-3 amperes typically drawn from batteries to the 40 ampere level, this approach is impractical in the home device application described for two reasons. First, incorporation of a suitable transformer adds weight, volume and cost; and secondly, a step-up in current via a transformer necessarily is accompanied by a corresponding step-down in voltage. Thus, for example, a transformer that converts 2 A at the input to 40 A and 2 V at the output has a turns ratio of 20:1, and thus utilizes an input voltage of 40 V. Since batteries are typically 1.2-1.5 V output, either many batteries (greater than 25), or voltage boost circuitry would likely be employed. These complexities add further to the weight, size and cost of the device. Alternatively, one might consider the addition of a “supercapacitor” (i.e. a high-capacitance electrical component that has recently become commercially available, termed an UltraCapacitor by Maxwell, Inc. of San Diego, Calif.) with a capacitance of 1 farad or more. This device can provide very high current, but unlike a battery its output voltage decreases rapidly at constant current output, in addition to adding its own weight and volume.
- The handle of the preferred apparatus contains a rechargeable battery pack containing five “sub-C” size nickel-metal-hydride or similar batteries, capable of powering the device without a main storage capacitor or transformer for approximately 300-500 pulses between recharges. That is, the circuit of the preferred embodiment is a “direct drive” electrical circuit wherein the current flowing from the batteries during a light pulse is substantially equal to the current flowing through the light source, or is substantially equal to the sum of the currents flowing in parallel through multiple light sources. The voltage provided by the batteries will not be substantially greater than the voltage applied to the light source due to small voltage drops at various resistances in the circuit.
- The electrical battery serves as the source of electrical power in a preferred embodiment. The electrical battery could be comprised of (a) a battery that drives the light source directly, which is the preferred direct-drive electrical circuit, or alternatively (b) a battery that charges a supercapacitor that drives the light source, (c) a battery that charges a capacitor that drives the light source, (d) a supercapacitor that drives the light source directly, or (e) a supercapacitor that charges a capacitor that drives the light source. The chemical battery may be non-rechargeable, such as alkaline, or re-chargeable, such as nickel-metal hydride (Ni—MH). A rechargeable battery would provide greater convenience and lower cost for the user. For topology regarding the alternative embodiment (c), a Ni—MH battery of about 50 cm3 and 170 g would provide for about 15 minutes of operation. The capacitor would be about 50 cm3 and 50 g.
- Nickel-metal-hydride batteries are preferred over Li-ion batteries, which have substantially lower peak current capabilities. Ni—Cd batteries have undesirably low energy densities, although they do have lower series resistances. The Ni—MH batteries selected have a battery capacity of 3 Ampere-hours (Ah) at a voltage of 1.25 V and can easily generate the 500 pulses. These batteries are preferably and advantageously factory installed. That is, they are preferably only replaceable at the factory (e.g., during a refurbishment). An alternative consumer-replaceable battery embodiment, either disposable or rechargeable, involves a more complex design and higher cost. Such an alternative would involve battery contacts rather than soldered wires, and since the circuit of the preferred embodiment drives approximately 40 A, even 25 milliohms of contact resistance results in a one volt drop which is very undesirable in that it represents a considerable fraction of the total battery voltage available. Soldered battery contacts, which are preferred, have much lower resistance.
- Electrical Circuit Details
-
FIG. 11 shows the salient features of an electrical circuit in accordance with a preferred embodiment. Incidental components have been lumped into the various blocks of the circuit diagram. Although detail within each of the blocks is not shown, it is submitted that those skilled in the art can implement each of the blocks. The electrical circuit for powering and controlling the hair-regrowth-inhibition apparatus of the preferred embodiment is advantageously robust and efficient in driving a pair of laser diode bars within a cordless, hand-held, and self-contained device. The details of control electronics can vary greatly from the description below, and as schematically illustrated by the block diagram inFIG. 11 , and as shown in some more detail inFIG. 12 in accordance with a preferred and exemplary embodiment. - The controller of the device is the
processor 888. Contained within the processor block is a microcontroller such as a PIC18LF452, manufactured by Microchip Technologies of Chandler, Ariz. Such a controller has many analog I/O, digital I/O, onboard read access memory (RAM), nonvolatile memory (FLASH and EEPROM), and other features that make it inexpensive, small and convenient to use in a self-contained device that is relatively small and lightweight compared with conventional office-based devices. Although the device does not need to employ the use of a microcontroller, using one makes the capabilities of the device greater than it would be otherwise possible for a given size. Alternatively, it may be possible to use a custom application-specific integrated circuit (ASIC) for the processor and much of the other electronics. Thetrigger button 826 is used by the operator of the device to signal that a treatment pulse is desired. Atrigger switch 826 may be omitted if thecontact sensors 819 and 820 are used as a means to signal that the operator desires a treatment pulse. Theprocessor 888 communicates with the other blocks through various signals. The processor may communicate with peripheral devices through aserial interface port 836. The processor may also have aprogramming port 837 by which the microcontroller may be programmed while preferably already soldered into the circuit. Theprogramming port 837 may also be used with an in-circuit-debugger (ICD) to make design and debugging of the software more convenient. - A device in accordance with a preferred embodiment is powered by
battery pack 806 and DC/DC converter 887. The number of batteries in the battery pack are sufficient to drive current through thelaser diodes 800, or LED, flashlamp or other alternative light source,current sense resistors battery pack 806 is then between 5.0 V and 7.5 V. - The DC/
DC converter 887 monitors thepower button 825, a wake-up signal 838 from thebattery charger 886, and a shutdown signal from theprocessor 888. The DC/DC converter 887 signals theprocessor 888 if thepower button 825 is depressed via the power switch signal 834. A signal proportional to the battery voltage is communicated by the DC/DC converter 887 to theanalog conditioning electronics 889 via the batteryvoltage monitor signal 827. The DC/DC converter 887 produces the various voltage levels required to power the other blocks of the circuit, namely areference voltage 828, FETgate drive voltage 829,electronics supply voltage 830, and a switchedbattery voltage 831 that can be switched on and off by the DC/DC converter 887. The blocks in the diagram shown inFIG. 11 preferably each have a connection to the signal common 807 which may or may not be shown. Since any switch between the battery and other components would develop a parasitic voltage drop, the battery pack voltage provided to the laser diode loop is not switched independent of the sentinel FET(s) 802 and control FET's 803. The absence of a switch is shown via thebattery signal 805. - The
battery charger 886 is used to charge thebattery pack 806. A commonly available low power, 9 VDC, 500 mA power adapter (not shown) can be connected at theDC power jack 824. Thebattery charger 886 has a fast-charge mode that charges thebattery pack 806 with a current of about 450 mA and a trickle-charge mode that charges thebattery pack 806 with a current of about 30 mA. The battery charge mode may be selected by theprocessor 888 via the fast charge signal 839. The processor is informed of the charge state of the battery pack via one of the signals in theanalog signal bus 841. When a DC adapter is connected to theDC power jack 824, the battery charger can signal the DC/DC converter 887 to wake up via the wake-up signal 836 and can signal theprocessor 888 via the chargevoltage monitor signal 840. Because the processor knows of the presence of the power adapter and the charge state of the batteries, an intelligent algorithm may be used for fast recharging of thebatteries 806. - The
analog conditioning circuitry 889 amplifies and converts the signal impedance, where necessary, of the various analog voltages that are sent to theprocessor 888. These signals include the laserdiode cathode voltage 813, thecurrent sense signal 814, thebattery voltage 827, skinsensor detector signal 842,reference voltage 828, and voltages representative of thetemperatures sensors cooler elements 858; and thebattery pack 806 and main circuit board. The conditioned analog signals are conveyed to the processor over theanalog signal bus 841. - The purpose of the
skin sensor circuitry 890 is to distinguish the presence of skin from other materials at the output aperture of the device. Light emitting diodes (LED's) 853 and 854 are used to illuminate the output aperture of the device. Remitted light is sensed bydetectors processor 888 may select which LED to illuminate via address bus 843. The signal fromdetectors analog conditioning electronics 889 via thedetector signal 842. Theprocessor 888 can then compare the detector signal for each LED against the known expected value for skin. In this way, skin can be distinguished from many other materials. In a preferred embodiment, five LED's, emitting light in the blue, green, yellow, red, and infrared portions of the electromagnetic spectrum are used. Simple silicon phototransistors are used to detect the remitted light. Greater or fewer LED's may be used to increase or decrease, respectively, the degree to which the skin sensor can reliably distinguish between skin and other materials. - The fan and
TE module electronics 891 provide power to thefan 857 andTE module 858. Afan signal 844 and TE module signal 845 from theprocessor 888 determine if the fan andTE module electronics 891 provide power to thefan 857 andTE module 858, respectively. - Visual indicators used to communicate with the operator include three LED's, power 859, ready 860, and battery 861. An
audible indicator 862 is also preferably used to provide user feedback. The audible indicator is especially advantageous on a self-contained device since the operator may have difficulty seeing the device if used for self-treatment of areas of the body that do not enable the direct view of the visual indicators 859, 860, and 861. The power indicator 859 is used to signal to a person that the device is on. The ready indicator 860 signals that the device has initialized, is at the proper operating temperature, and that the user may begin treatment. The battery indicator 861 signals the charge state of the battery. All three indicators may be steadily illuminated (in addition to other preferred conditions) for the device to emit a treatment light pulse. Thespeaker 862 may be used to indicate power on, power off, a treatment pulse, and/or many other events through the use of different tones and various tone sequences and durations. Each of these indicators has an associated control signal from the processor 888:speaker signal 846,battery signal 847,ready signal 848, and power signal 849. - The
contact sensor electronics 880 are used to detect contact of the output aperture and/or output window component of the device with a firm surface such as skin. One or more sensors, 819 and 820, may be used to sense contact of different portions of the output aperture. Three simple contact closures implemented through the use of a membrane switch commonly found in cell phone keypads, calculator keypads, or other electronics are used to detect contact in the device of the preferred embodiment. Other contact sensors using light, ultrasound, electrical resistively or other physical phenomena may be used. The state of the contact sensors are communicated to theprocessor 888 via thecontact bus 821. The processor may use a complex algorithm for determining if sufficient contact is provided before it signals the other control electronics that a treatment pulse may be initiated and maintained. Thecontact sensor electronics 880 also may directly (and redundantly) signal thepulse enabling electronics 881 via acontact signal 815. - The
current control electronics 885 provide closed-loop control of the current flowing through thelaser diodes 800. The differential voltage across current sense resistor 1 (804) is monitored by thecurrent control electronics 885 and is proportional to the current flowing through thelaser diodes 800. This differential voltage is amplified and compared to a set point voltage that can be adjusted by thecurrent setpoint resistor 812. The voltage on the gate of the control FET's 803 is continuously adjusted by thecurrent control electronics 885 to ensure that the proper current is flowing. When no treatment pulse is desired, as indicated by the pulse not signal 823, thecurrent control electronics 885 turns off the control FET's 803. - The
current limit electronics 884 are used to monitor the current flowing through current sense resistor 2 (801). In a similar fashion as thecurrent control electronics 885, thecurrent limit electronics 884 amplifies the differential voltage developed across current sense resistor 2 (801) and compares this voltage with a voltage set bycurrent limit resistor 811. If the current flowing through current sense resistor 2 (801) exceeds the limit, then an over-current error is signaled to both the pulse enableelectronics 881 and theprocessor 888 via the over-current error not signal 810. - The
pulsewidth limit electronics 882 are used to monitor the pulsewidth of the treatment pulse. An independent time base (different from that used by the processor 888) is used to ensure the duration of any treatment pulse does not exceed a time set by thepulsewidth limit resistor 817. If theprocessor 888 requests a pulse via the pulse not signal 823 that exceeds the pulsewidth limit then thepulsewidth limit circuitry 882 signals theprocessor 888 and pulse enableelectronics 881 via the pulse width error not signal 818. - The pulse rate frequency (PRF, or repetition rate) limiting
electronics 883 are used to ensure that treatment pulses are not emitted more frequently than desired. If sufficient time is not allowed by theprocessor 888 between pulses requested on the pulse not signal 823, then thePRF limiting electronics 883 indicates an error to thepulse enabling electronics 881 via the PRF limit not signal 816. - The
pulse enabling electronics 881 ensure signals from other blocks indicate that the other blocks have satisfied their requirements prior to the initiation of a treatment pulse. These signals may include: contact 815, noover-current condition 810, nopulsewidth error condition 818, no pulse rate frequency (PRF) error 816, and the presence of a processor enablesignal 822. If all of these enable signals are present, the pulse enableelectronics 881 turns on the gate of the sentinel FET's 802 via a sentinel gate signal 809. If at any time any of the signals that are monitored by thepulse enabling electronics 881 indicate that the pulse should not continue, the sentinel FET's 802 are turned off by thepulse enabling electronics 881 and the output may be terminated mid-pulse. - The laser energizing circuit loop is shown comprised of the following elements: the
laser diodes 800,battery pack 806, current sense resistor 1 (804), current sense control FET's 803, sentinel FET's 802, and current sense resistor 2 (801). This loop is shown in more detail inFIG. 12 . -
FIG. 12 shows the detailed schematics of the circuitry used to control the current to the laser diode bars. As indicated inFIG. 12 , thebattery pack 806 positive and negative electrodes are be connected at terminals J4 and J2, respectively. The laser diode bar cathode and anode are connected at terminals J1 and J3, respectively.Current sense resistor 1, R1, andcurrent sense resistor 2, R2, are shown as 0.002 ohm resistors. The current control FET's are shown as a parallel connection of two FET's Q2 and Q4. The sentinel FET's are shown as a parallel connection of two FET's, Q1 and Q3. Resistors R3, R4, R5, and R6 are a part of the control electronics not shown discretely in the block diagram ofFIG. 11 . Resistors R3 and R4 are connected to the gates of the sentinel FET's and current control FET's, respectively, so that the transistors turn off if either gate signal is for some reason disconnected. R5 and R6 are used to generate the laser diodecathode voltage signal 813 ofFIG. 11 . The capacitors C1, C2, C3, and C4 are used to reduce the switching noise of the FET's and may not be necessary. -
FIG. 11 andFIG. 12 show the salient features of an electrical circuit that can be used in accordance with a preferred embodiment. An advantageous feature of the design illustrated inFIG. 11 andFIG. 12 is that the laser diodes are powered directly by the battery pack. Here, the phrase, “powered directly,” or, as used elsewhere herein, the phrase, “direct drive,” are intended to mean that the instantaneous current flowing through the battery and the instantaneous current flowing through the laser diodes at a particular moment in time are substantially equivalent. The instantaneous currents differ only in that a small amount of current drawn from the batteries is used to power the control electronics. This architecture is markedly different from and advantageous over state-of-the-art laser systems and flashlamp systems used for hair-regrowth inhibition due to various efficiencies that it provides. - Efficient Electrical Circuit Design
- There is significant architectural advantage in the circuit of
FIGS. 11 and 12 over conventional pulse power circuits for delivering 40 ampere current pulses for energizing pulsed laser systems. Most circuits that are capable of delivering large current pulses rely on a main storage capacitor to store the electrical charge that is to be delivered during the pulse. For example, state-of-the-art hair removal systems like the LightSheer diode laser system, the Quantum flashed lamp system, and the Altus CoolGlide all have large banks of capacitors that are re-charged by a DC power source between pulses. In contrast, the system of the preferred embodiment includes a direct drive electrical circuit. As described above, the circuit directly switches current pulses from the batteries to the laser electrodes and does not include a main storage capacitor. Such main storage capacitor would involve a large bank of capacitors due to the low energy density of capacitors. Moreover, preferably no step-up or step-down transformer is used in the direct drive electrical circuit. This permits the size and weight of the apparatus of the preferred embodiment to be significantly less than a circuit including a main storage capacitor and/or transformer; and so in accordance with one of the goals of the design of the preferred embodiment, the additional size and weight of a main storage capacitor bank and transformer are avoided. - In addition, in capacitor-based systems, as current is delivered by a capacitor bank the stored charge decreases, and the voltage across the capacitors drops significantly (voltage=charge/capacitance). The drop in voltage means that the initial DC voltage would need to be larger than desired so that there would be sufficient voltage available to continue to drive the system as the capacitors discharge. Thus, greater waste power would be generated across the control FET's 803 during the beginning of the pulse when the voltages have not dropped significantly. This would be inconsistent with the desire to have an energy-efficient circuit for the hand-held, cordless apparatus of the preferred embodiment. Further size and weight advantages are achieved in the direct drive electrical circuit of the preferred embodiment by avoiding use of a transformer.
- Advantageous to the efficient use of power of this device is the use of laser diode bars 800. In
FIG. 11 , the symbol for a single diode is used to represent the series connection of one or more, and preferably two, laser diode bars. Laser diodes are much more efficient at converting electrical power to optical power than other lasers. In the preferred embodiment, two laser diode bars are connected in series.Laser diode 800 can be 40-watt, 808-nm packages manufactured by Cutting Edge Optronics, of St. Charles, Mo., part number ASM06C040W080810B80 or similarly packaged laser diode bars 800. Asingle diode bar 800 may be used if the optical power delivered is sufficient for therapeutic results. However, an efficient laser source is preferably combined with efficient batteries and circuit design in order to realize a self-contained and hand-held hair-regrowth-inhibition device. - Therefore, in the circuit of the preferred embodiment, the size of the batteries and the electrical circuit configuration are such that main storage capacitors are not required. Instead, the laser diodes are driven “directly” from the DC power source, or the battery pack. The usable voltage of the battery pack is reduced by the product of the current and the equivalent series resistance of the batteries (voltage=current.times.−resistance), and so the batteries include advantageously small series resistances. Also, the batteries are capable of supplying approximately 40 A without damage. Although the most recent battery technology is lithium-ion, nickel-metal hydride or alternatively, nickel-cadmium, are preferred, because the maximum peak current draw is much greater than Li-ion can provide, for a given battery size. The choice of battery within
battery pack 806 is strongly driven by its equivalent series resistance, or ESR. When drawing large currents from a battery, significant voltage can develop across this parasitic resistance. The voltage developed due to ESR is subtracted from the nominal battery voltage and so reduces the voltage available to circuits the battery is powering. The ESR is preferably low enough so that, when 40 A is drawn frombattery pack 806, the resulting parasitic voltage drop is small compared to the voltage output of thebattery pack 806. The “compact C” Ni—MH batteries have been selected for these and other reasons already mentioned. The batteries that comprisebattery pack 806 may be Panasonic HHR300SCP Ni—MH rechargables, Panasonic P-170SCRP NiCd batteries, sold by Panasonic Matsushita Electric Corporation of America, Secaucus, N.J., or similar batteries. - Another advantage of the circuit design of the preferred embodiment is that voltage drops are minimized and/or avoided in many places. In
FIG. 12 , the laser diode bars are shown connected in series with the battery, FET's and current sense resistors. Minimizing the voltage developed across the components powered by the batteries is advantageous because this will determine the minimum voltage and hence the minimum number of battery cells that are included in the design and thus in part establish a lower limit on the weight and size of the apparatus. Voltage drops across the FET's, the current sense resistors, the laser diodes, the battery series resistance, and the circuit board traces and the other interconnections between these components have been taken into consideration. - The
current sense resistors current control electronics 885 andcurrent limit electronics 884 serve to amplify the voltages to levels that are more readily used by the feedback circuitry. - The control FET's 803 are the FET's that control the current flowing in the circuit. Any excess voltage supplied by the batteries, that is, voltage greater than that involved in driving the desired current through the laser diodes, is dropped across the control FET's 803. However, as the batteries are discharged and the battery voltage decreases, there will not be excess voltage supplied by the battery, and so the voltage that develops across the FET's for the case when the batteries are nearly depleted is advantageously minimized in accordance with a preferred embodiment, because the FET's chosen have very low on-resistance (rds-on). The transistors shown, IRL3716 (International Rectifier Corp., El Segundo, Calif.), are actually 180 A/200 W transistors and are larger than are needed for merely current and power requirements. However, their low on-resistance is advantageous for this application. In addition, to lower the voltage developed across the FET's, two transistors in parallel are preferred instead of just one so that only approximately 20 A flows through each transistor.
- The sentinel FET's 802 are used to shut off the current if an error condition exists (for example, if one of the control FET's 803 fail such that current flows when it should not). The sentinel FET's 802 are chosen with preferably the same criteria as the control FET's 803 with one exception. Since the sentinel FET's 802 are used only digitally to permit any current set by the control FET's 803 or restrict any current, the FET's are either turned on “hard” or else turned off completely. In both of these states, little power is dissipated by the sentinel FET's 802 and so the transistor's packaging can have worse thermal performance than the packaging of the control FET's 803. For this reason, in
FIG. 12 , transistors such as IRF7832 (International Rectifier Corp.) may be used for transistors Q1 and Q3. IRL3716 transistors would be acceptable for use as FET's 802; however, they would undesirably add to the size, cost, and weight of the device. - The series resistance of the FET's is further reduced by enabling the circuit to supply relatively high voltages to the gates of each of the transistors. The on-resistance of FET's sharply depends inversely on the magnitude of gate-to-source voltage applied to the device. The DC/
DC converter electronics 887 inFIG. 11 produce an FETgate drive voltage 829. In the preferred embodiment thegate drive voltage 829 produced by the DC/DC converter is 7.6 volts even when the battery pack voltage drops to less than 5 volts. This voltage is greater than the battery pack voltage and is present so that the FET gate-to-source voltage, Vgs, of each of the FET's can be driven to a greater value than would be possible if the magnitude of the voltage was limited by the battery pack voltage. This is especially true as the batteries become depleted and the battery voltage decreases to less than its fully charged level. - The control FET's 803 and sentinel FET's 802 are located in a way that minimizes the length of the traces and interconnects, isolates the current paths from sensitive circuitry, and provides a means of conductively rejecting the waste heat produced by the transistors to the
finned heat exchanger 620 ofFIG. 10 . Wide, short traces and redundant traces on multi-layer boards achieve this. In a preferred embodiment, conventional electrical connectors are not used in the high current path so as to eliminate connector resistances. Instead, components are soldered at the factory. This represents a trade-off between ease of manufacture and repair with reductions in voltage drops throughout the circuit, wherein even milliohm parasitic resistances are avoided wherever possible. - Optical Output Specifications
- Although particular output specifications for light pulses emitted from the apparatus of the preferred embodiment will be explained in more detail below, an exemplary device in accordance with a preferred embodiment may produce light pulses according to the following summary of parameters:
- Output fluence: 18 J/cm2
- Spot size (or output aperture area): 1 cm2
- Pulsewidth: 0.300 s
- Pulse repetition frequency: 0.5 Hz
- Wavelength: 808 nm
- Therefore, the peak optical power is 60 W and coverage rate is 30 cm2 per minute. These provide efficacious and practical treatment specifications. As will also be detailed below, these particular parameters fall within ranges for minimum and maximum quantities for the preferred device. These ranges preferably include:
- Output fluence range: 4 J/cm2 to 100 J/cm2
- Spot size (or output aperture area): 0.25 cm2 to 2 cm2
- Pulsewidth: 0.010 s to 1 s, or more preferably 0.100 s to 0.500 s
- Pulse repetition frequency: 0.1 Hz to 2 Hz
- Wavelength: 700 nm to 1100 nm
- Optical Peak Power (Peak Power): 10 W to 120 W.
- Output Fluence
- Throughout this patent application the term output fluence is intended to describe the fluence at the output aperture or output window of the dermatologic treatment apparatus. For purposes of clarification, the output fluence of the device is also termed below as Fsource.
- Among the most important output parameters, it is generally preferred to have a source fluence Fsource between 4 J/cm2 and 100 J/cm2. For pulse durations in the 0.3 ms to 3 ms range, temporary hair regrowth inhibition has been found clinically with output fluences as low as 4-5 J/cm2. However, for pulse durations extending into the many tens to hundreds of milliseconds, it is believed that output fluences below about 10 J/cm2 are unlikely to have significant effect. In the absence of actual clinical trials at these parameters, it cannot be established more precisely, and in any case will vary from person to person and even with body site on a single person.
- Output fluences over approximately 100 J/cm2 would be expensive to produce, unless an undesirably small spot size or excessively long pulse width is utilized. In addition, if this fluence is exceeded in less than 1000 ms, it is likely to be very painful or even cause burning of the skin. The fluence that the skin can tolerate is generally affected by at least four parameters. The first is the extent to which the epidermis is kept from rising in temperature while the target below is heated. In this regard, the preferred device includes a thermally-conductive contact surface made of sapphire, or alternatively incorporates some form of active cooling of the contact surface or the skin such as using a fan. Alternatively, cryogen spray may be used to cool the skin to be treated.
- As discussed above, the safety of a home device is enhanced with lower output fluences. Further, higher output fluences, e.g., achieving twice the fluence with a same spot size involves twice the number of laser diode bars and probably twice the batteries. Thus the practical design constraints of a self-contained, hand-held, cordless, self-care device on safety, weight, size, and cost suggest that output fluences less than about 100 J/cm2 are desired.
- The laser diode bars of the
light source 140 preferably emit light pulses such that a majority of the energy is in the spectral band of 700 nm to 1100 nm, and particularly around 800 nm, although visible wavelengths may also be used; bandwidths between approximately 1 nm and 10 nm; pulse durations preferably between 3-10 milliseconds (ms) and one second, and more preferably between 100 ms and 500 ms and particularly around 300 ms, at a repetition rate of between 0.1 Hz and 2 Hz, and particularly between 0.25 Hz and 1 Hz. - Wavelength
- Another significant parameter is the wavelength of the light. In general, the longer the wavelength, at least over a range between 400 nm and 1100 nm, the higher the fluence tolerated by the skin, because the absorption of light by the melanin present in skin decreases monotonically with increasing wavelength over this range.
- In a hair-regrowth-inhibition procedure, melanin in the hair shaft and follicle absorbs light, resulting in thermal injury to the follicle and delayed regrowth. Thus one might assume that light having a shorter wavelength would be preferred, since these wavelengths are more strongly absorbed. However, the melanin in the skin overlying the hair follicle also absorbs more light at these wavelengths, reducing the fluence tolerated by the skin. Theoretical calculations and clinical results have determined that optimum results for hair-regrowth inhibition are obtained for most skin types when the light source has an output in the spectral band between 700 nm and 1100 nm. Wavelengths longer than 1100 nm, in addition to having very low melanin absorption, also become problematic due to water absorption, which begins to limit optical penetration depth making the apparatus less efficient.
- The preferred wavelength of emission of the
light source 140, preferably made up of one or more laser diode bars, is thus between approximately 700 nm and 1100 nm. In the case where a flashlamp is utilized as the light source, particularly for other dermatologic procedures, a wavelength of 500 nm to 1100 nm may be preferred, since flashlamps are inherently broadband sources, and thus a broader wavelength range may be involved for achieving the desired fluence. - In addition, if blood vessels are targeted, the increased absorption of blood at wavelengths in the region of 510-580 nm make somewhat shorter wavelengths desirable.
- In the case where LED's are utilized as the light source, higher power LED's may be available at wavelengths below 700 nm; thus a wavelength range of 600 nm to 1100 nm may be preferred.
- Bandwidth
- The pulses emitted by the
light source 140 are generated preferably by energizing the laser diode bars with 40 A for less than half a second. Therefore during the application of this energy, the laser diode material warms from about 20.degree. C. to about 50.degree. C., or a difference of 30.degree. C. over the duration of the pulse. The emission wavelength particularly of III-V emitter materials such as AlxGa1-xAs varies with temperature. For example, λ(T) may vary by about 0.3 nm/.degree. C. Therefore, the emission wavelength may vary by about 9 nm during the pulse, and the effective bandwidth of the pulse is then generally about 1 nm and may be between about 5 nm and 10 nm. Where used herein, bandwidth is defined as the full-width half-maximum of the energy spectrum. - Sources such as diode lasers or LED's, that typically have bandwidths of less than 40 nm, are generally preferred over flashlamps because they have higher electrical-to-optical conversion efficiency.
- Pulse Repetition Frequency
- The repetition rate of pulses, or pulse repetition frequency, is preferably between approximately 0.1 Hz and 2 Hz, and particularly between around 0.25 Hz and 1 Hz, or between one pulse every second to one pulse every four seconds. A repetition rate any faster than 1-2 Hz is not desired owing to the expense and weight of a device capable of producing pulses this rapidly. Moreover, the self-care user of the device, whether it is a person at home applying the light to his or her own skin, or a user treating another person's skin, would find it difficult to manipulate the apparatus over the application area of the skin at higher repetition rates. On the other hand, a repetition rate slower than one pulse every four to ten seconds would render the coverage rate of the apparatus annoyingly slow for home use. That is, the application time simply becomes too long even for small treatment areas.
- A higher repetition would translate into a higher coverage rate or more skin area treated per minute, which is desirable. However, a higher repetition rate also involves a higher average input power since the average optical power is higher. This higher electrical power requirement, in addition to increased volume, weight and cost, creates a problem of waste heat from the laser diode bars of the preferred apparatus.
- Pulse Duration
- Another important parameter is pulse duration. If the epidermis is kept from rising excessively in temperature, the energy can be continued to be applied into the hair follicle over a time that is roughly the thermal relaxation time of the stem cell region of the follicle, e.g., for approximately 100 ms to 500 ms. With contact cooling, the epidermis is kept from getting too hot; and much more fluence, or energy over a given area, can be applied into the dermis if it is applied over a longer time period.
- The preferred pulse duration of the apparatus is above 3-10 ms and below approximately one second or even 500 ms. Pulse durations below around 10 ms, and particularly below 3-8 ms, are not desired for the light-based hair-regrowth-inhibiting apparatus, because to achieve adequate energy deposition in such a short time requires high optical peak powers. For example, application of an energy density of 20 J/cm2 in a 0.8 cm2 spot area (16 J) in a 10 ms pulse involves a optical peak power of 1600 W. This very high peak power is expensive to generate. For example, with diode laser bars each having a optical peak power of 30 W, over 50 bars would be used, and this is too many for a self-contained, hand-held and cordless device. It is also more difficult to render the device eye-safe, which is important in a home use, self-care device, because the maximum permissible exposure (MPE) is much less for short pulses such as these. That is, the MPE scales as the pulse duration to the three-quarter power, or t0.75, and for eye safety, it is therefore generally more desirable to have longer pulses at desired output fluences than short ones. The thermal relaxation time of the hair follicle is generally at least 10 ms and may be as high as 100 ms to 600 ms for the stem cells surrounding the hair follicle, and so for the reasons provided, it is particularly desired to have pulse durations at least as long as this thermal relaxation time, such that a particularly preferred minimum pulse duration may be 100 ms or more.
- On the other hand, as pulse durations get too long, such as above between 600 ms and one second, heat which is initially deposited into the melanin-laden hair shaft diffuses beyond the hair follicle. Somewhere in this pulse duration regime a transition gradually occurs from spatially-selective heating of just the follicle (and surrounding stem cells) to so-called bulk-heating of the dermis. If the pulse duration is increased at constant energy (or constant fluence), the optical peak power eventually gets so low that the target does not get sufficiently hot to cause hair-regrowth inhibition. If the peak power is kept constant as the pulse duration is increased, the fluence can get so high that the bulk heating becomes painful and/or may even cause skin burns.
- It is noted that use of the term pulse, or pulse duration, is intended to include not only a single pulse in the conventional sense, but also a train of discrete pulses (“sub-pulses”) or modulated pulse over the same time duration. In general, for the purposes of this patent application, these sub-pulses are considered to be one pulse if the time duration between the start of the first sub-pulse and the end of the last sub-pulse in a group is less than the time period between groups of such sub-pulses.
- Optical Peak Power
- It would be difficult to effect even temporary hair-regrowth inhibition, e.g., temporary delay in hair regrowth, if the optical peak power of the light source is below approximately 10 W. At peak powers below this threshold, very long pulse durations would be involved to approach a lower limit on output fluence, e.g., 4 J/cm2. For example, to get an output fluence of 10 J/cm2 in a 0.8 cm2 spot (i.e., and output energy of 8 J) a pulse duration of 800 ms is required at a peak power of 10 W.
- At peak powers of over approximately 100-120 W, considerable energy can be generated in a pulse having a more desirable duration and a useful spot size. However, higher peak powers are difficult to obtain in an inexpensive, self-contained, battery-powered self-care device.
- Spot Size
- There are multiple undesirable effects if the spot size, or area of skin illuminated by light pulses propagated from the apparatus, is too small. (In cases where the output aperture of the device is close to, or in contact with, the skin, the spot size on the skin and the output aperture of the device are approximately equal in size.) First, a very small spot, e.g., less than 0.25 cm2, renders only one hair to be treated at a time in a hair-regrowth-inhibition procedure. In addition, some sort of visual targeting would be involved to ensure that the spot is indeed over a target follicle. Second, a small spot implies a very low coverage rate; i.e. to cover a given number of square centimeters of skin containing unwanted hairs, the smaller the spot size the longer the treatment time. This problem can be mitigated to some extent by increasing the pulse repetition rate, but doing this involves more electrical power, more expense, and more weight. Third, while a small spot size would appear to be quite advantageous in the sense that a low energy can still generate a high fluence on the skin surface (since fluence is energy divided by area), the fluence at some depth within the skin where the target cells are located is substantially reduced by scattering within the skin. The smaller the spot size, especially below about 0.25 to 0.5 cm2, the more pronounced the effective lessening of fluence at depth relative to fluence at the surface. In short, if one goes to too small a spot, the end result can be either burning of the epidermis (to get enough fluence in the dermis) or no efficacy due to inadequate fluence at depth.
- At the other end of the range, a larger spot size is desirable primarily because of enhanced coverage rate. For example, at a spot size between 2 cm2 and 4 cm2 spot size per pulse, entire legs could be treated in less than 30 minutes, assuming a pulse repetition frequency of roughly one pulse per second. However, for a given output fluence and pulse duration, the optical peak power required scales linearly with the spot size, and the cost and weight become prohibitive once the spot size gets above approximately 1.0 to 2.0 cm2.
- Skin Color
- A parameter that is not a characteristic of the output pulses of a dermatologic treatment device, but that has a significant influence on the effect of light-based treatment, is skin color. People with fair skin, e.g., of Scandinavian descent (so-called Type I), can handle perhaps six to eight times the fluence on the skin compared to a black person with so-called type VI skin. With good contact cooling, a several hundred millisecond pulse, an 800 nm source and Type I skin, an output fluence as high as 100 J/cm2 would be usable without significant epidermal injury. However, most Caucasians have type II or type III skin, and 50 j/cm2 might be the damage limit. For darker skin, the limit may be closer to 30 J/cm2. Although in a preferred embodiment, only a fixed output fluence is generated by the device (as well as only a single pulse duration being factory set), due to the various skin types of users, an alternative embodiment of the apparatus includes means of lowering the output fluence either continuously or discretely in a high-medium-low embodiment, where the high setting still corresponds to a maximum potential fluence at the eye of a person below the maximum permissible exposure (MPE) as detailed below. The advantage would be that darker-skinned persons may find the high setting painful, and therefore might prefer the medium or low setting, while still maintaining acceptable efficacy.
- Eye Safety Overview
- Increased divergence and reduced spatial coherence, and resulting increase in eye safety, is accomplished by incorporating into the path of the beam of light within the apparatus, a diffusing material through which the light travels prior to leaving the apparatus, as in the second embodiment shown in
FIG. 2A . Alternatively, the divergence may be increased and spatial coherence reduced by incorporating into the device a diffusing surface upon which the beam strikes prior to leaving the device, as in the third embodiment shown inFIG. 2B . - To compensate for any light that is absorbed within the apparatus by the introduction of the diffuser, the output power from the light source within the apparatus can be increased. Alternatively, the diffusing material or diffusing surface can be chosen to be substantially non-absorbing and the light source housing can be constructed so that the internal surfaces are substantially non-absorbing so that substantially all of the light will be emitted from the output aperture of the apparatus, albeit after one or more scattering events from the diffusing material or diffusing surface, or light source housing.
- Although the fluence of the light emitted by the output aperture will generally decrease as it propagates away from the apparatus due to the divergent nature of the beam, many of the chromophores within the skin that are targeted by light-based treatments are near the surface of the skin. If the target is much closer to the surface of the skin than the size of the output aperture of the apparatus, there will be little decrease of fluence at the chromophore due to divergence of the emission. Since skin itself is a highly scattering medium for much of the electromagnetic spectrum, the decrease in fluence at the target when using a very divergent source with little or no spatial coherence is relatively insignificant when compared to the fluence at the target produced by a collimated light source that has equal fluence at the surface of the skin; provided that the distance from the output window or aperture of the source to the target beneath the skin surface is small compared to the lateral dimension of the source (e.g., the diameter of the output window).
- Calculations of Maximum Permissible Exposures and Fluences at the Eye of a Person
- To evaluate eye safety under the ANSI, IEC or ICNIRP guidelines, two values are calculated and compared. The first is the Maximum Permissible Exposure (MPE). This value is the fluence or irradiance that is considered safe for the human eye, measured at the cornea. The actual value of the MPE varies greatly depending on the characteristics of the light source in question; specifically, the source wavelength, pulse duration, coherence, and, if incoherent (e.g., from a diffuse source) the angle formed by the dimension of the source and its distance from the cornea (the so-called angular subtense that determines the size of the corresponding image of the source on the retina; see International Standard IEC 60825.1, “Safety of Laser products—Part 1: Equipment classification, requirements and user's guide”, Edition 1.2, August 2001; p. 11.).
- The second value “Fcornea” is the fluence produced at the cornea from a particular light source, as measured through a pair of apertures limiting the angle of acceptance to 100 milliradians (see IEC 60825.1, above, p. 40,
NOTE 2, sub-note d.). The value of Fcornea depends upon both the fluence produced by the device at its output (the “output fluence”), as well as how the light diverges from the output as it propagates toward the eye. For any light source, if Fcornea is less than the MPE for all possible distances between the source and the eye, the device is considered eye-safe. Conversely, a light source that produces, at any particular distance, a value for Fcornea that exceeds the MPE is considered hazardous. - For wavelengths of light between 400 nm and 1,050 um, and pulse durations between 18 microseconds and 10 seconds, the Maximum Permissible Exposure (MPE) at the cornea is given by the following equation:
-
MPE(J/cm2)=1.8*10−3 t 0.75 C 4 C 6 [Eq. 1] - where
- t is the pulse duration in seconds;
- C4 is a correction factor for the wavelength λ of light, having the following values:
- for λ greater than 400 nm but less than 700 nm (visible light), C4=1;
- for λ greater than 700 nm but less than approximately 1100 nm (near-infrared light),
-
C 4=100.002(λ-700) [Eq. 2] - note that C4 increases from a value of 1 at 700 nm and has a value of 5 at 1,050 nm;
- C6 is a correction factor that is equal to 1 for coherent sources (this is strictly correct for sources that have a spatial coherence near the diffraction limit; for multimode sources or for arrays of coherent sources the calculation is more complex); and for diffuse, extended sources is given by C6α/αmin where αmin is equal to 1.5 milliradians and a is the angular subtense of the source, i.e.
-
α=2 tan−1 (d/2r)≈d/r [Eq. 3] - where d is the diameter of the source and r is the distance from the source to the cornea.
-
Equation 3 applies only up to an angular subtense of 100 milliradians; above this angle, a value of 66.7 is used for C6. - Two cases are considered below to exemplify the eye hazard associated with typical current devices for dermatologic treatment:
- 1. A visible, coherent source (e.g., a laser), having a circular output aperture of one centimeter squared (diameter of 1.13 cm) and a 30 millisecond pulse duration;
- 2. An incoherent, directed source (e.g., a flashlamp) having a rectangular output aperture of 1 cm by 2 cm and a 30 ms pulse duration.
- For a source of diameter d=1.13 cm, the angular subtense of the source varies depending on the distance r from the eye; however, because in this example the source is a laser in the visible region of the spectrum (in this example it is assumed that the laser is highly spatially coherent), both C4 and C6 are equal to 1, and the maximum permissible exposure at the cornea given by
Equation 1 is: -
MPE=1.8*10−3 t 0.75 C 4 C 6=1.8*10−3(0.072)(1)(1)=1.3*10−4J/cm2 - or 130 microjoules per square centimeter. This fluence is of the order of 100,000 times lower than the fluence involved in the therapeutic dermatologic treatment of typical skin problems such as hair-regrowth inhibition. It is of course true that the fluence exiting the 1 cm2 laser aperture could be much higher than the 130 μJ/cm2 figure calculated above; for eye safety it is understood that only the fluence at the cornea, Fcornea, be no higher than this figure for the laser source in this example. But such a source, if it is to be efficacious for the dermatologic treatments mentioned, would produce at least a few joules per square centimeter at its exit aperture, and it is illustrated below that this type of source will always exceed the MPE at some distance. For example, suppose for eye safety reasons that the beam is designed to be highly divergent upon leaving the exit aperture; for example, by passing the beam through a very fast f/0.8 concave lens as shown in
FIG. 4 . (An f/0.8 lens has a focal length equal to 0.8 times its diameter.) This beam exits the lens at an angle φ of about 0.56 radians, or 32 degrees. The fluence at a distance r from the exit aperture is given by (this is approximately correct for a Gaussian beam from a diffraction-limited laser): -
Fluence F≈4Q/π(rφ)2 [Eq. 4] - Where Q is the energy of the source. So for a source of 5 J/cm2 output fluence from a 1 cm2 aperture, the fluence at a distance of, for example, 20 cm (i.e. the output aperture of the device is 20 cm from the eye) is approximately 50 mJ/cm2 still several thousand times above the MPE. Any adjustment factors for pulse duration or longer wavelength to increase the MPE would not be nearly sufficient to make this device eye safe; for example, increasing the wavelength to 1050 nm and the pulse duration to 300 ms results in only a roughly 30-fold increase in MPE, to about 4000 μJ/cm2 (i.e., increase due to pulse duration is (300/30)0.75 or about 5.6; increase in A from visible to 1050 nm increases C4 from 1 to 5; so combined increase is 5.6 times 5, or about a factor of 28).
- A popular device for hair-regrowth inhibition as well as for facial “rejuvenation” utilizes a flashlamp with visible and near infrared output and an exit aperture of 1 cm by 2 cm, and an output energy of 80 J (40 j/cm2) (see Hode, L, “Are lasers more dangerous than IPL instruments?” Lasers in Surgery and Medicine, Supplement 15, 2003, p. 6; and poster presentation at corresponding conference). Such sources typically have a directed output of about plus or minus 20 degrees, i.e. a solid angle Ω of about 0.4 steradians: If it is assumed that (very roughly) half of the output energy is in the visible, and half is in the 700 nm-900 nm range, a value of the wavelength correction factor C4 of ˜1.3 is appropriate. The conclusions of this section are insensitive to this parameter in any case. Because this device emits incoherent light, the correction factor C6 appropriate for “extended sources” can be greater than one, and in fact will reach 66.7 when the angular subtense of the source is 100 milliradians, i.e. when the source is roughly 15 cm from the eye (see International Standard IEC 60825-1, p. 52. For non-circular sources the angular subtense is the arithmetic mean of the larger and smaller angular dimensions of the source). It should be noted that, once the source subtends an angle greater than 100 milliradians (i.e. comes yet closer to the eye) the hazard to the eye remains the same, because although the irradiance on the cornea increases, the image area on the retina increases proportionally. From Equation 1:
-
MPE(J/cm2)≈1.8*10−3 C 4 C 6=1.8*10−3(0.030)0.75*1.3*66.7=11mJ/cm2 - The fluence F at a distance r from a source of energy Q directed into a solid angle .OMEGA. is approximately:
-
F≈Q/(r 2Ω)=80/(152*0.4)=890mJ/cm2 - Thus, in this case
-
F cornea=890mJ/cm2 - or approximately 80 times in excess of the MPE; still an extreme eye hazard. To make this device eye safe the fluence would have to be reduced by this factor, i.e., from 40 J/cm2 to ˜0.5 J/cm2, significantly below the fluence necessary to perform therapeutic photothermal dermatologic treatment.
- Calculations analogous to those above can be done for an embodiment of the invention herein, as follows. As shown in
FIG. 5 , alight source 310, which can be either a coherent source such as a laser or an incoherent source such as a flashlamp, impinges on adiffuser 320. The diffuser in turn emits the scattered light preferably as an approximately Lambertian source in the forward direction (see Earle Brown, Modern Optics, Reinhold Publishing Corporation, 1965; p. 225). Light backscattered from the diffuser toward the laser or flashlamp can be reflected to impinge once again on the diffuser by incorporating reflective walls in thechamber 330 and on the surface oflight source holder 340 that faceschamber 330. It should be noted, however, that such reflective walls only serve to improve the overall efficiency and spatial uniformity of the device and are in no way essential to the invention. In addition, thediffuser 320 need not be located at the exit aperture, but may be recessed withinchamber 330; in this case the walls ofchamber 330 between thediffuser 320 and the exit aperture should be non-absorbing. It should also be noted that the diffuser has the added advantage of removing any “hot spots” from the light source; i.e., a source such as an array of diode laser emitters has much higher integrated radiance in some directions than in others; such localized variations will be smoothed out by a diffuser. In this embodiment a disk diffuser of the Oriel type is described, but the invention can also be effected with a different type of diffuser, as defined earlier. - For the sole purpose of providing a concrete example, let us assume that the device has a circular output aperture of area one square centimeter, as in Example 1 above. Let us further assume that the device has a wavelength of 800 nm. From
Equation 2, C4 is equal to 1.58. As in Example 2 above, we also assume that the device is at a distance from the cornea such that the source (e.g., the diffuser located at the output aperture) subtends an angle of 100 milliradians (C6=66.7). For a source of 1.13 cm diameter (1 cm2 area) this distance is about 11.3 cm. Under these conditions, from Equation 1: -
MPE(J/cm2)=1.8*10−3 t 0.75 C 4 C 6=1.8*10−3(0.072)(1.58)(66.7)=13.7mJ/cm2 - For a Lambertian source, the fluence at a distance r (when looking directly into the source) for a source of energy Q is given by
-
F(J/cm2)=Q/πr 2 [Eq. 5] - Thus, for our source at a distance of 11.3 cm, the fluence at the cornea is equal to the MPE of 13.6 mJ/cm2 when Q is equal to 5.5 joules. Since our source has an aperture of 1 cm2, this corresponds to a source fluence of 5.5 J/cm2. Thus our invention can have a source fluence of 5.5 J/cm2 for providing an intended photothermal injury to the skin and yet have an output below that which would result in an exposure to the eye in excess of the MPE:
-
F source=5.5J/cm2 -
F cornea=MPE=13.7mJ/cm2 - As stated above, for this source to be considered eye safe, the fluence at the cornea from the device must be less than the calculated MPE for all distances between the source and the eye, not merely the distance chosen in the above example. This can be shown to be true, as follows.
- For distances less than 11.3 cm (i.e. as the output aperture of the source is drawn closer to the eye, causing the angular subtense of the source to exceed 100 mrad) the MPE remains the same. With decreasing distance, the fluence from the source increases, but Fcornea remains constant because, as described above, it is measured through apertures limiting the angle of acceptance to 100 mrad. Thus, if Fcornea is less than the MPE at a source distance corresponding to an angular subtense of the source of 100 mrad, it is also safe at lesser distances.
- Considering now the opposite case, where the source is moved farther from the eye than 11.3 cm, two cases will be considered: that case where the distance from the source to the eye is such that its angular subtense is more than 1.5 mrad but less than 100 mrad (for a source of 1.13 cm diameter, distances between 11 cm and 750 cm) and that case where the source subtends an angle of less than 1.5 mrad (distances of greater than 750 cm). In the first case, the MPE decreases linearly with increasing distance, but from Equation 5, Fcornea decreases as the square of the distance. Thus, if
-
Fcornea<MPE at α=100mrad -
then -
Fcornea<MPE for 1.5mrad <α<100mrad - Considering now the last case, where the distance from the source to the eye is such that the angular subtense is less than 1.5 mrad (for the source above, distances of greater than 750 cm), the values for MPE and Fcornea vary as follows: as the distance increases, the MPE remains constant, but as above, Fcornea continues to decrease as the square of the distance. Thus one can conclude that the above source is safe at any distance.
- As introduced above, one or both of the following additional features is preferably included to allow even higher device fluences that are nonetheless still eye-safe. These features include an increase of the pulse duration of the light (e.g., from 30 ms to 300 ms), and an increase in the wavelength of the light (e.g., from visible to infrared); both of which result in a higher MPE for the eye and thus allow an increased therapeutic output that is still eye-safe. The benefits of each of these elements (diffuse source, extended pulse duration, and longer wavelength) can be quantified, as described above and below. In short summary, however, pulse durations in excess of 100 ms and wavelengths above 700 nm are preferred, while as maxima, pulse durations are maintained at or below 500 ms and wavelengths below approximately 1100 nm.
- In order to further enhance the utility of the device and its use, the pulse duration can also be extended to preferably 300 ms from 30 ms, or in a preferred range between 100 ms and 500 ms. In a number of therapeutic dermatologic procedures including light-based hair-regrowth inhibition, pulse durations of 300 ms or greater are and/or may be an effective optimum. From
Equation 1, in this case the MPE increases by a factor of (0.3/0.03)0.75 or about 5.6. Thus the light source in our example can have an output fluence 5.6 times greater than calculated above, or approximately 31 J/cm2, and it will still not exceed the MPE at any distance. - Note that this calculated value of 31 J/cm2 for a source fluence that is eye-safe agrees well with the corresponding value derived from the Accessible Emission Limit (AEL) as determined by the CDRH for a Class I laser device. Devices below the Class I AEL are considered to be eye-safe and therefore require no specific warning labels or other controls. From Table I of 21 CFR 1040.10, a laser device meets the Class I AEL if its integrated radiance is less than the value below:
-
AEL=10k 1 k 2 t 1/3J/(cm2 sr). - Since, for our source,
- k1=1.56;
- k2=1; and
- t1/3=(0.300)1/3=0.67,
- then, AEL=10.4 J/(cm2 sr).
- For a Lambertian source, the source fluence (radiant exposure) is related to the integrated radiance L through the formula:
-
Fsource=πL; thus -
F source(max)=(3.14sr)(10.4J/(cm2 sr))=32.6J/cm2 - Thus, the device will be below the Class I Accessible Emission Limit if the source fluence is less than 32.6 J/cm2, a value that agrees well with the 31 J/cm2 calculated earlier from the IEC limits for Maximum Permissible Exposure. There may be further calculations or methods for determining an eye safe limit as may be required by the FDA or a different standards setting organization or in a different country or setting. Although any of these eye safe limits are understood to be at least approximately the values calculated as the AEL and the MPE limits, the value used may differ and devices constructed accordingly may differ in their output limitations. Any such adhered to or acknowledged reasonable eye safety limitation is intended to be included within the meaning and use of the term “eye safe” as used in the present application.
- Further Optical Design Considerations
- The addition of a diffuser to a light-based dermatologic device to permit therapeutic fluences at the skin surface while ensuring eye-safe operation is by no means limited to the preferred and alternative embodiments described above and elsewhere herein. For example, a device for the treatment of acne using blue or other visible light can be made eye safe at therapeutic fluences by the addition of a diffuser; and a device for repigmentation of skin, or treatment of psoriasis or vitiligo, using ultraviolet light (290 nm to 400 nm) can also be made much safer with a diffuser added to the output aperture. In general, such devices contain incoherent sources with a directed output; i.e. the output beam expands from the output aperture by ˜±20 degrees, corresponding to a solid angle of about 0.4 steradians. By the addition of a diffuser, the output propagates into a full 2πsteradians; if the diffuser creates a Lambertian distribution of the light (as is the case with an Oriel-type diffuser) the angular dependence of the output fluence will have the well-known cosine dependence, while other elements also described as diffusers for the purposes of this application may have a more general variation of fluence with viewing angle. When typical devices without a diffuser (i.e. devices which may have, for example, a light output spreading into .about.0.4 steradians) are viewed on-axis, i.e. directly into the source, the addition of the diffuser (backed by a chamber having reflective walls) reduces the fluence at the cornea by the ratio of (0.4/π), or about 0.13, without affecting the fluence of the device when applied to the skin. Thus a device that produces a fluence at the cornea which exceeds the MPE by up to eight times can be made eye safe by the addition of a diffuser.
- It should be noted that the fluence can be increased by up to an additional factor of two (while still remaining eye-safe) by altering the output distribution of the light from Lambertian to that approaching a uniform source. This can be effected, for example, by creating concentric micro-grooves (either by diamond-machining of sapphire or casting of plastic) such that an increased fraction of the light is refracted into higher angles, as illustrated at
FIG. 3B , or incorporating a point source and mirrored chamber design as illustrated atFIG. 3D . - The output pulses of the apparatus described above are described in terms of energy (i.e., radiant exposure and integrated radiance) rather than in terms of power (i.e., irradiance and radiance); but the invention applies equally to devices and/or methods characterized either by energy or power.
- Preferred and alternative embodiments of the invention may also include any one or a combination of the following elements. First, as described earlier, the heat removal element may be a thermal battery that is “recharged” (i.e., heat is removed) or replaced prior to use and absorbs heat during use. The thermal battery may be a phase-change material, such as ice, certain paraffin-like waxes or salts such as TEA29 from TEAP Energy, or may be a high-heat capacity material like copper or aluminum or water, or may be a compressed gas or liquid that cools by expansion to lower pressure. Second, a pigmentation sensor may be included that senses the amount of pigment in the skin. Such a sensor may be used to adjust output parameters such as pulse duration or pulse energy or to prohibit operation for pigmentation levels higher than a pre-selected threshold. Third, a means of operation that is sliding, rather than sequential spot-wise treatment, may be employed. By sliding, it is meant that the device is operated by continuously sliding the active area of the device across the skin. The light may be delivered in pulses or continuously. The device may provide feedback to the user to help maintain dosimetry within a given range and/or may have a mechanism or internal feedback, such as provided by an optical or mechanical sensor, to help maintain dosimetry within a given range. Fourth, non-contact cooling may be employed, such as spray cooling or liquid cooling or cooling with an gel applied to the skin. Fifth, reflective or diffusive surfaces or elements on or within the device may be used that may redirect light that has been scattered back to the device from the skin back into the skin. Such redirection of remitted light may occur by specular or diffuse reflection, such as from a partially transmissive diffuser near the output aperture or from reflective surfaces within or on the device. (As stated earlier, the term “reflective” is used in this context to include remissive surfaces.)
- In addition to hair-regrowth inhibition, the invention can also be advantageously applied to other dermatology applications, including treatments for acne, benign pigmented lesions, vascularity, skin texture, skin wrinkles, and “photo-rejuventation” which is generally accepted in the field to mean skin treatment for pigmented lesions (including brown and red spots), vascularity (including the destruction of small blood vessels), and/or skin tone, skin texture, and skin wrinkles. For these applications, the invention may be modified from the preferred embodiment hair-regrowth-inhibition device to make the device more optimal for the application. Some modifications to preferred and alternative embodiments described herein may be understood by those skilled in the art for alternative application in the above fields. For example, for the treatment of acne, a wavelength between 350-450 nm may be chosen for its photodynamic effect on the porphrins produced by the acne bacteria. Alternatively, a wavelength in the range 1000-1800 nm may be chosen to match the absorption spectrum of sebum, a major component in acne. Likewise, for “photorejuvenation” a broad-band source, such as a flashlamp, may be used in order to simultaneously treat vascular and pigmented lesions and improve skin tone, texture, and wrinkles. For photorejuvenation, somewhat shorter wavelengths have been shown to be efficacious; e.g., 500-1100 nm. For dermatologic applications, the output fluences are generally desired to be greater than 4 J/cm2 to be efficacious and the light is generally not eye-safe at these levels, although in accordance with a preferred embodiment, a diffuser is employed to reduce the maximum fluence at a person's eye to below the MPE.
- Also, “divergent” light sources such as diode laser light sources are referred to herein. Light is defined herein as “divergent” when the divergence angle .alpha. is greater than approximately ±6 degrees, where the divergence is defined as the geometric mean of the half-angle formed between the principal propagation axis (z-axis) and the full-width half-maximum (FWHM) energy axes in the x and y coordinate directions. That is, if the divergence from the z-axis in the x-direction is ±αx and the divergence in the y-direction is ±αy, then the divergence ±α equals the square root of the quantity ±α*±αy. For example, diode laser bars typically have a FWHM beam divergence of about ±20 degrees in one axis and about ±5 degrees in the other axis, so have a typical divergence of about ±10 degrees as defined here. Thus, diode laser bars are a divergent light source. Diode lasers in general, flashlamps, and LED's are also typically divergent sources. A divergence value of 6 degrees clearly differentiates “divergent” sources, such as diode lasers and flashlamps, from “collimated” sources, which in practice have some divergence but typically less than 1 degree. Divergent light sources are superior to other light sources for achieving eye safety, in that a significant portion of the light from such divergent sources striking the diffuser is already partially directed at significant angles from the principal propagation direction. Thus the task of the diffuser to spread the light into large angles is simplified.
- While an exemplary drawing and specific embodiments of the present invention have been described and illustrated, it is to be understood that that the scope of the present invention is not to be limited to the particular embodiments discussed. Thus, the embodiments shall be regarded as illustrative rather than restrictive, and it should be understood that variations may be made in those embodiments by workers skilled in the arts without departing from the scope of the present invention, as set forth in the appended claims and structural and functional equivalents thereof.
- In addition, in methods that may be performed according to preferred embodiments herein and that may have been described above, the operations have been described in selected typographical sequences. However, the sequences have been selected and so ordered for typographical convenience and are not intended to imply any particular order for performing the operations, unless expressly set forth in the claims or as understood by those skilled in the art as being necessary.
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WO2016154343A1 (en) * | 2015-03-23 | 2016-09-29 | Akari Systems, Inc. | Methods of application of therapeutic light sources |
WO2016171639A1 (en) * | 2015-04-24 | 2016-10-27 | Robin Kozmetik Guzellik Merkezi Medikal Ozel Egitim Ogretim Metal Urunleri Temizlik Urun Ve Gida Maddeleri Ithalat Ihracat Sanayi Ticaret Ltd. Sti. | A selective photothermolysis epilation device |
US9629814B2 (en) | 2010-09-30 | 2017-04-25 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator configured to redistribute compressive forces |
US9649110B2 (en) | 2013-04-16 | 2017-05-16 | Ethicon Llc | Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output |
US9690362B2 (en) | 2014-03-26 | 2017-06-27 | Ethicon Llc | Surgical instrument control circuit having a safety processor |
US9687237B2 (en) | 2011-09-23 | 2017-06-27 | Ethicon Endo-Surgery, Llc | Staple cartridge including collapsible deck arrangement |
US9693777B2 (en) | 2014-02-24 | 2017-07-04 | Ethicon Llc | Implantable layers comprising a pressed region |
US9700310B2 (en) | 2013-08-23 | 2017-07-11 | Ethicon Llc | Firing member retraction devices for powered surgical instruments |
US9706991B2 (en) | 2006-09-29 | 2017-07-18 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising staples including a lateral base |
US9724094B2 (en) | 2014-09-05 | 2017-08-08 | Ethicon Llc | Adjunct with integrated sensors to quantify tissue compression |
US9724098B2 (en) | 2012-03-28 | 2017-08-08 | Ethicon Endo-Surgery, Llc | Staple cartridge comprising an implantable layer |
US9730697B2 (en) | 2012-02-13 | 2017-08-15 | Ethicon Endo-Surgery, Llc | Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status |
US9737303B2 (en) | 2004-07-28 | 2017-08-22 | Ethicon Llc | Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism |
US9743929B2 (en) | 2014-03-26 | 2017-08-29 | Ethicon Llc | Modular powered surgical instrument with detachable shaft assemblies |
US9750501B2 (en) | 2007-01-11 | 2017-09-05 | Ethicon Endo-Surgery, Llc | Surgical stapling devices having laterally movable anvils |
US9775614B2 (en) | 2011-05-27 | 2017-10-03 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments with rotatable staple deployment arrangements |
US9795381B2 (en) | 2007-06-04 | 2017-10-24 | Ethicon Endo-Surgery, Llc | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US9795383B2 (en) | 2010-09-30 | 2017-10-24 | Ethicon Llc | Tissue thickness compensator comprising resilient members |
US9801628B2 (en) | 2014-09-26 | 2017-10-31 | Ethicon Llc | Surgical staple and driver arrangements for staple cartridges |
US9801634B2 (en) | 2010-09-30 | 2017-10-31 | Ethicon Llc | Tissue thickness compensator for a surgical stapler |
US9808246B2 (en) | 2015-03-06 | 2017-11-07 | Ethicon Endo-Surgery, Llc | Method of operating a powered surgical instrument |
US9814462B2 (en) | 2010-09-30 | 2017-11-14 | Ethicon Llc | Assembly for fastening tissue comprising a compressible layer |
US9820738B2 (en) | 2014-03-26 | 2017-11-21 | Ethicon Llc | Surgical instrument comprising interactive systems |
US9826978B2 (en) | 2010-09-30 | 2017-11-28 | Ethicon Llc | End effectors with same side closure and firing motions |
US9833238B2 (en) | 2010-09-30 | 2017-12-05 | Ethicon Endo-Surgery, Llc | Retainer assembly including a tissue thickness compensator |
US9833242B2 (en) | 2010-09-30 | 2017-12-05 | Ethicon Endo-Surgery, Llc | Tissue thickness compensators |
US9833241B2 (en) | 2014-04-16 | 2017-12-05 | Ethicon Llc | Surgical fastener cartridges with driver stabilizing arrangements |
US9844375B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Drive arrangements for articulatable surgical instruments |
US9844374B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
US9844376B2 (en) | 2014-11-06 | 2017-12-19 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
US9867618B2 (en) | 2008-02-14 | 2018-01-16 | Ethicon Llc | Surgical stapling apparatus including firing force regulation |
US9872682B2 (en) | 2007-03-15 | 2018-01-23 | Ethicon Llc | Surgical stapling instrument having a releasable buttress material |
US9883860B2 (en) | 2013-03-14 | 2018-02-06 | Ethicon Llc | Interchangeable shaft assemblies for use with a surgical instrument |
US9895148B2 (en) | 2015-03-06 | 2018-02-20 | Ethicon Endo-Surgery, Llc | Monitoring speed control and precision incrementing of motor for powered surgical instruments |
US9895147B2 (en) | 2005-11-09 | 2018-02-20 | Ethicon Llc | End effectors for surgical staplers |
US9901342B2 (en) | 2015-03-06 | 2018-02-27 | Ethicon Endo-Surgery, Llc | Signal and power communication system positioned on a rotatable shaft |
US9901346B2 (en) | 2008-02-14 | 2018-02-27 | Ethicon Llc | Stapling assembly |
US9907620B2 (en) | 2012-06-28 | 2018-03-06 | Ethicon Endo-Surgery, Llc | Surgical end effectors having angled tissue-contacting surfaces |
US9913642B2 (en) | 2014-03-26 | 2018-03-13 | Ethicon Llc | Surgical instrument comprising a sensor system |
US9913648B2 (en) | 2011-05-27 | 2018-03-13 | Ethicon Endo-Surgery, Llc | Surgical system |
US9924961B2 (en) | 2015-03-06 | 2018-03-27 | Ethicon Endo-Surgery, Llc | Interactive feedback system for powered surgical instruments |
US9924944B2 (en) | 2014-10-16 | 2018-03-27 | Ethicon Llc | Staple cartridge comprising an adjunct material |
US9943309B2 (en) | 2014-12-18 | 2018-04-17 | Ethicon Llc | Surgical instruments with articulatable end effectors and movable firing beam support arrangements |
US9962161B2 (en) | 2014-02-12 | 2018-05-08 | Ethicon Llc | Deliverable surgical instrument |
US9962158B2 (en) | 2008-02-14 | 2018-05-08 | Ethicon Llc | Surgical stapling apparatuses with lockable end effector positioning systems |
US9974538B2 (en) | 2012-03-28 | 2018-05-22 | Ethicon Llc | Staple cartridge comprising a compressible layer |
US9987000B2 (en) | 2014-12-18 | 2018-06-05 | Ethicon Llc | Surgical instrument assembly comprising a flexible articulation system |
US9993258B2 (en) | 2015-02-27 | 2018-06-12 | Ethicon Llc | Adaptable surgical instrument handle |
US10004498B2 (en) | 2006-01-31 | 2018-06-26 | Ethicon Llc | Surgical instrument comprising a plurality of articulation joints |
US10045776B2 (en) | 2015-03-06 | 2018-08-14 | Ethicon Llc | Control techniques and sub-processor contained within modular shaft with select control processing from handle |
US10045778B2 (en) | 2008-09-23 | 2018-08-14 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US10045781B2 (en) | 2014-06-13 | 2018-08-14 | Ethicon Llc | Closure lockout systems for surgical instruments |
US10052044B2 (en) | 2015-03-06 | 2018-08-21 | Ethicon Llc | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US10052102B2 (en) | 2015-06-18 | 2018-08-21 | Ethicon Llc | Surgical end effectors with dual cam actuated jaw closing features |
US10058963B2 (en) | 2006-01-31 | 2018-08-28 | Ethicon Llc | Automated end effector component reloading system for use with a robotic system |
US10064621B2 (en) | 2012-06-15 | 2018-09-04 | Ethicon Llc | Articulatable surgical instrument comprising a firing drive |
US10064688B2 (en) | 2006-03-23 | 2018-09-04 | Ethicon Llc | Surgical system with selectively articulatable end effector |
US10070861B2 (en) | 2006-03-23 | 2018-09-11 | Ethicon Llc | Articulatable surgical device |
US10070863B2 (en) | 2005-08-31 | 2018-09-11 | Ethicon Llc | Fastener cartridge assembly comprising a fixed anvil |
US10076325B2 (en) | 2014-10-13 | 2018-09-18 | Ethicon Llc | Surgical stapling apparatus comprising a tissue stop |
US10076326B2 (en) | 2015-09-23 | 2018-09-18 | Ethicon Llc | Surgical stapler having current mirror-based motor control |
US10085748B2 (en) | 2014-12-18 | 2018-10-02 | Ethicon Llc | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
US10085751B2 (en) | 2015-09-23 | 2018-10-02 | Ethicon Llc | Surgical stapler having temperature-based motor control |
US10098642B2 (en) | 2015-08-26 | 2018-10-16 | Ethicon Llc | Surgical staples comprising features for improved fastening of tissue |
US10098636B2 (en) | 2006-01-31 | 2018-10-16 | Ethicon Llc | Surgical instrument having force feedback capabilities |
US10105139B2 (en) | 2015-09-23 | 2018-10-23 | Ethicon Llc | Surgical stapler having downstream current-based motor control |
US10117649B2 (en) | 2014-12-18 | 2018-11-06 | Ethicon Llc | Surgical instrument assembly comprising a lockable articulation system |
US10117652B2 (en) | 2011-04-29 | 2018-11-06 | Ethicon Llc | End effector comprising a tissue thickness compensator and progressively released attachment members |
US10149683B2 (en) | 2008-10-10 | 2018-12-11 | Ethicon Llc | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US10172620B2 (en) | 2015-09-30 | 2019-01-08 | Ethicon Llc | Compressible adjuncts with bonding nodes |
US10180463B2 (en) | 2015-02-27 | 2019-01-15 | Ethicon Llc | Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band |
US10188385B2 (en) | 2014-12-18 | 2019-01-29 | Ethicon Llc | Surgical instrument system comprising lockable systems |
US10201363B2 (en) | 2006-01-31 | 2019-02-12 | Ethicon Llc | Motor-driven surgical instrument |
US10206676B2 (en) | 2008-02-14 | 2019-02-19 | Ethicon Llc | Surgical cutting and fastening instrument |
US10211586B2 (en) | 2017-06-28 | 2019-02-19 | Ethicon Llc | Surgical shaft assemblies with watertight housings |
US10213201B2 (en) | 2015-03-31 | 2019-02-26 | Ethicon Llc | Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw |
US10226249B2 (en) | 2013-03-01 | 2019-03-12 | Ethicon Llc | Articulatable surgical instruments with conductive pathways for signal communication |
US10238386B2 (en) | 2015-09-23 | 2019-03-26 | Ethicon Llc | Surgical stapler having motor control based on an electrical parameter related to a motor current |
US10245030B2 (en) | 2016-02-09 | 2019-04-02 | Ethicon Llc | Surgical instruments with tensioning arrangements for cable driven articulation systems |
US10245032B2 (en) | 2005-08-31 | 2019-04-02 | Ethicon Llc | Staple cartridges for forming staples having differing formed staple heights |
US10245033B2 (en) | 2015-03-06 | 2019-04-02 | Ethicon Llc | Surgical instrument comprising a lockable battery housing |
US10258418B2 (en) | 2017-06-29 | 2019-04-16 | Ethicon Llc | System for controlling articulation forces |
US10258331B2 (en) | 2016-02-12 | 2019-04-16 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10258333B2 (en) | 2012-06-28 | 2019-04-16 | Ethicon Llc | Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system |
US10265068B2 (en) | 2015-12-30 | 2019-04-23 | Ethicon Llc | Surgical instruments with separable motors and motor control circuits |
US10265074B2 (en) | 2010-09-30 | 2019-04-23 | Ethicon Llc | Implantable layers for surgical stapling devices |
US10271849B2 (en) | 2015-09-30 | 2019-04-30 | Ethicon Llc | Woven constructs with interlocked standing fibers |
US10271846B2 (en) | 2005-08-31 | 2019-04-30 | Ethicon Llc | Staple cartridge for use with a surgical stapler |
US10278780B2 (en) | 2007-01-10 | 2019-05-07 | Ethicon Llc | Surgical instrument for use with robotic system |
US10292704B2 (en) | 2015-12-30 | 2019-05-21 | Ethicon Llc | Mechanisms for compensating for battery pack failure in powered surgical instruments |
US10293100B2 (en) | 2004-07-28 | 2019-05-21 | Ethicon Llc | Surgical stapling instrument having a medical substance dispenser |
US10299878B2 (en) | 2015-09-25 | 2019-05-28 | Ethicon Llc | Implantable adjunct systems for determining adjunct skew |
US10307170B2 (en) | 2017-06-20 | 2019-06-04 | Ethicon Llc | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US10314589B2 (en) | 2006-06-27 | 2019-06-11 | Ethicon Llc | Surgical instrument including a shifting assembly |
USD851762S1 (en) | 2017-06-28 | 2019-06-18 | Ethicon Llc | Anvil |
US10327769B2 (en) | 2015-09-23 | 2019-06-25 | Ethicon Llc | Surgical stapler having motor control based on a drive system component |
US10327767B2 (en) | 2017-06-20 | 2019-06-25 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
US10335145B2 (en) | 2016-04-15 | 2019-07-02 | Ethicon Llc | Modular surgical instrument with configurable operating mode |
USD854151S1 (en) | 2017-06-28 | 2019-07-16 | Ethicon Llc | Surgical instrument shaft |
US10357247B2 (en) | 2016-04-15 | 2019-07-23 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US10363031B2 (en) | 2010-09-30 | 2019-07-30 | Ethicon Llc | Tissue thickness compensators for surgical staplers |
US10363037B2 (en) | 2016-04-18 | 2019-07-30 | Ethicon Llc | Surgical instrument system comprising a magnetic lockout |
US10363036B2 (en) | 2015-09-23 | 2019-07-30 | Ethicon Llc | Surgical stapler having force-based motor control |
US10368864B2 (en) | 2017-06-20 | 2019-08-06 | Ethicon Llc | Systems and methods for controlling displaying motor velocity for a surgical instrument |
US10368865B2 (en) | 2015-12-30 | 2019-08-06 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10376263B2 (en) | 2016-04-01 | 2019-08-13 | Ethicon Llc | Anvil modification members for surgical staplers |
US10390841B2 (en) | 2017-06-20 | 2019-08-27 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
US10398434B2 (en) | 2017-06-29 | 2019-09-03 | Ethicon Llc | Closed loop velocity control of closure member for robotic surgical instrument |
US10398433B2 (en) | 2007-03-28 | 2019-09-03 | Ethicon Llc | Laparoscopic clamp load measuring devices |
US10405859B2 (en) | 2016-04-15 | 2019-09-10 | Ethicon Llc | Surgical instrument with adjustable stop/start control during a firing motion |
US10413294B2 (en) | 2012-06-28 | 2019-09-17 | Ethicon Llc | Shaft assembly arrangements for surgical instruments |
US10420549B2 (en) | 2008-09-23 | 2019-09-24 | Ethicon Llc | Motorized surgical instrument |
US10420550B2 (en) | 2009-02-06 | 2019-09-24 | Ethicon Llc | Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated |
US10426463B2 (en) | 2006-01-31 | 2019-10-01 | Ehticon LLC | Surgical instrument having a feedback system |
US10426467B2 (en) | 2016-04-15 | 2019-10-01 | Ethicon Llc | Surgical instrument with detection sensors |
US10426471B2 (en) | 2016-12-21 | 2019-10-01 | Ethicon Llc | Surgical instrument with multiple failure response modes |
US10426481B2 (en) | 2014-02-24 | 2019-10-01 | Ethicon Llc | Implantable layer assemblies |
US10441285B2 (en) | 2012-03-28 | 2019-10-15 | Ethicon Llc | Tissue thickness compensator comprising tissue ingrowth features |
US10448948B2 (en) | 2016-02-12 | 2019-10-22 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10448950B2 (en) | 2016-12-21 | 2019-10-22 | Ethicon Llc | Surgical staplers with independently actuatable closing and firing systems |
US10456137B2 (en) | 2016-04-15 | 2019-10-29 | Ethicon Llc | Staple formation detection mechanisms |
US10463370B2 (en) | 2008-02-14 | 2019-11-05 | Ethicon Llc | Motorized surgical instrument |
US10485543B2 (en) | 2016-12-21 | 2019-11-26 | Ethicon Llc | Anvil having a knife slot width |
US10485536B2 (en) | 2010-09-30 | 2019-11-26 | Ethicon Llc | Tissue stapler having an anti-microbial agent |
US10492783B2 (en) | 2016-04-15 | 2019-12-03 | Ethicon, Llc | Surgical instrument with improved stop/start control during a firing motion |
US10492785B2 (en) | 2016-12-21 | 2019-12-03 | Ethicon Llc | Shaft assembly comprising a lockout |
US10499914B2 (en) | 2016-12-21 | 2019-12-10 | Ethicon Llc | Staple forming pocket arrangements |
USD869655S1 (en) | 2017-06-28 | 2019-12-10 | Ethicon Llc | Surgical fastener cartridge |
US10499890B2 (en) | 2006-01-31 | 2019-12-10 | Ethicon Llc | Endoscopic surgical instrument with a handle that can articulate with respect to the shaft |
US10517594B2 (en) | 2014-10-29 | 2019-12-31 | Ethicon Llc | Cartridge assemblies for surgical staplers |
US10517590B2 (en) | 2007-01-10 | 2019-12-31 | Ethicon Llc | Powered surgical instrument having a transmission system |
US10517596B2 (en) | 2016-12-21 | 2019-12-31 | Ethicon Llc | Articulatable surgical instruments with articulation stroke amplification features |
US10524790B2 (en) | 2011-05-27 | 2020-01-07 | Ethicon Llc | Robotically-controlled surgical stapling devices that produce formed staples having different lengths |
US10537325B2 (en) | 2016-12-21 | 2020-01-21 | Ethicon Llc | Staple forming pocket arrangement to accommodate different types of staples |
US10568652B2 (en) | 2006-09-29 | 2020-02-25 | Ethicon Llc | Surgical staples having attached drivers of different heights and stapling instruments for deploying the same |
US10568626B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Surgical instruments with jaw opening features for increasing a jaw opening distance |
US10568625B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Staple cartridges and arrangements of staples and staple cavities therein |
US10575868B2 (en) | 2013-03-01 | 2020-03-03 | Ethicon Llc | Surgical instrument with coupler assembly |
US10588633B2 (en) | 2017-06-28 | 2020-03-17 | Ethicon Llc | Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing |
US10588623B2 (en) | 2010-09-30 | 2020-03-17 | Ethicon Llc | Adhesive film laminate |
US10588632B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical end effectors and firing members thereof |
USD879808S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with graphical user interface |
USD879809S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with changeable graphical user interface |
US10617416B2 (en) | 2013-03-14 | 2020-04-14 | Ethicon Llc | Control systems for surgical instruments |
US10617418B2 (en) | 2015-08-17 | 2020-04-14 | Ethicon Llc | Implantable layers for a surgical instrument |
US10617413B2 (en) | 2016-04-01 | 2020-04-14 | Ethicon Llc | Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts |
US10617412B2 (en) | 2015-03-06 | 2020-04-14 | Ethicon Llc | System for detecting the mis-insertion of a staple cartridge into a surgical stapler |
US10624633B2 (en) | 2017-06-20 | 2020-04-21 | Ethicon Llc | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument |
US10631859B2 (en) | 2017-06-27 | 2020-04-28 | Ethicon Llc | Articulation systems for surgical instruments |
US10646220B2 (en) | 2017-06-20 | 2020-05-12 | Ethicon Llc | Systems and methods for controlling displacement member velocity for a surgical instrument |
US10660640B2 (en) | 2008-02-14 | 2020-05-26 | Ethicon Llc | Motorized surgical cutting and fastening instrument |
US10667809B2 (en) | 2016-12-21 | 2020-06-02 | Ethicon Llc | Staple cartridge and staple cartridge channel comprising windows defined therein |
US10675028B2 (en) | 2006-01-31 | 2020-06-09 | Ethicon Llc | Powered surgical instruments with firing system lockout arrangements |
US10682134B2 (en) | 2017-12-21 | 2020-06-16 | Ethicon Llc | Continuous use self-propelled stapling instrument |
US10687813B2 (en) | 2017-12-15 | 2020-06-23 | Ethicon Llc | Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments |
US10687806B2 (en) | 2015-03-06 | 2020-06-23 | Ethicon Llc | Adaptive tissue compression techniques to adjust closure rates for multiple tissue types |
US10695062B2 (en) | 2010-10-01 | 2020-06-30 | Ethicon Llc | Surgical instrument including a retractable firing member |
US10716614B2 (en) | 2017-06-28 | 2020-07-21 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies with increased contact pressure |
USD890784S1 (en) | 2017-06-20 | 2020-07-21 | Ethicon Llc | Display panel with changeable graphical user interface |
US10716565B2 (en) | 2017-12-19 | 2020-07-21 | Ethicon Llc | Surgical instruments with dual articulation drivers |
US10729509B2 (en) | 2017-12-19 | 2020-08-04 | Ethicon Llc | Surgical instrument comprising closure and firing locking mechanism |
US10729501B2 (en) | 2017-09-29 | 2020-08-04 | Ethicon Llc | Systems and methods for language selection of a surgical instrument |
US10736636B2 (en) | 2014-12-10 | 2020-08-11 | Ethicon Llc | Articulatable surgical instrument system |
US10736628B2 (en) | 2008-09-23 | 2020-08-11 | Ethicon Llc | Motor-driven surgical cutting instrument |
US10743874B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Sealed adapters for use with electromechanical surgical instruments |
US10743851B2 (en) | 2008-02-14 | 2020-08-18 | Ethicon Llc | Interchangeable tools for surgical instruments |
US10743872B2 (en) | 2017-09-29 | 2020-08-18 | Ethicon Llc | System and methods for controlling a display of a surgical instrument |
US10743875B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member |
US10751076B2 (en) | 2009-12-24 | 2020-08-25 | Ethicon Llc | Motor-driven surgical cutting instrument with electric actuator directional control assembly |
US10758230B2 (en) | 2016-12-21 | 2020-09-01 | Ethicon Llc | Surgical instrument with primary and safety processors |
US10758229B2 (en) | 2016-12-21 | 2020-09-01 | Ethicon Llc | Surgical instrument comprising improved jaw control |
US10758233B2 (en) | 2009-02-05 | 2020-09-01 | Ethicon Llc | Articulatable surgical instrument comprising a firing drive |
US10765427B2 (en) | 2017-06-28 | 2020-09-08 | Ethicon Llc | Method for articulating a surgical instrument |
US10765429B2 (en) | 2017-09-29 | 2020-09-08 | Ethicon Llc | Systems and methods for providing alerts according to the operational state of a surgical instrument |
US10772629B2 (en) | 2017-06-27 | 2020-09-15 | Ethicon Llc | Surgical anvil arrangements |
US10779820B2 (en) | 2017-06-20 | 2020-09-22 | Ethicon Llc | Systems and methods for controlling motor speed according to user input for a surgical instrument |
US10779821B2 (en) | 2018-08-20 | 2020-09-22 | Ethicon Llc | Surgical stapler anvils with tissue stop features configured to avoid tissue pinch |
US10779826B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Methods of operating surgical end effectors |
US10779824B2 (en) | 2017-06-28 | 2020-09-22 | Ethicon Llc | Surgical instrument comprising an articulation system lockable by a closure system |
US10779825B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments |
US10779903B2 (en) | 2017-10-31 | 2020-09-22 | Ethicon Llc | Positive shaft rotation lock activated by jaw closure |
US10796471B2 (en) | 2017-09-29 | 2020-10-06 | Ethicon Llc | Systems and methods of displaying a knife position for a surgical instrument |
US10813639B2 (en) | 2017-06-20 | 2020-10-27 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions |
US10828033B2 (en) | 2017-12-15 | 2020-11-10 | Ethicon Llc | Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto |
US10828028B2 (en) | 2016-04-15 | 2020-11-10 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US10835330B2 (en) | 2017-12-19 | 2020-11-17 | Ethicon Llc | Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly |
US10842492B2 (en) | 2018-08-20 | 2020-11-24 | Ethicon Llc | Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system |
US10842490B2 (en) | 2017-10-31 | 2020-11-24 | Ethicon Llc | Cartridge body design with force reduction based on firing completion |
US10842491B2 (en) | 2006-01-31 | 2020-11-24 | Ethicon Llc | Surgical system with an actuation console |
US10856869B2 (en) | 2017-06-27 | 2020-12-08 | Ethicon Llc | Surgical anvil arrangements |
US10856870B2 (en) | 2018-08-20 | 2020-12-08 | Ethicon Llc | Switching arrangements for motor powered articulatable surgical instruments |
US10869666B2 (en) | 2017-12-15 | 2020-12-22 | Ethicon Llc | Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument |
WO2020256918A1 (en) * | 2019-06-20 | 2020-12-24 | Ethicon Llc | Fluorescence imaging in a light deficient environment |
USD906355S1 (en) | 2017-06-28 | 2020-12-29 | Ethicon Llc | Display screen or portion thereof with a graphical user interface for a surgical instrument |
US10881399B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument |
US10881396B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Surgical instrument with variable duration trigger arrangement |
USD907648S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
USD907647S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
US10888321B2 (en) | 2017-06-20 | 2021-01-12 | Ethicon Llc | Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument |
US10903685B2 (en) | 2017-06-28 | 2021-01-26 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies forming capacitive channels |
US10898183B2 (en) | 2017-06-29 | 2021-01-26 | Ethicon Llc | Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing |
US10912559B2 (en) | 2018-08-20 | 2021-02-09 | Ethicon Llc | Reinforced deformable anvil tip for surgical stapler anvil |
USD910847S1 (en) | 2017-12-19 | 2021-02-16 | Ethicon Llc | Surgical instrument assembly |
US10932772B2 (en) | 2017-06-29 | 2021-03-02 | Ethicon Llc | Methods for closed loop velocity control for robotic surgical instrument |
US10945731B2 (en) | 2010-09-30 | 2021-03-16 | Ethicon Llc | Tissue thickness compensator comprising controlled release and expansion |
USD914878S1 (en) | 2018-08-20 | 2021-03-30 | Ethicon Llc | Surgical instrument anvil |
US10966718B2 (en) | 2017-12-15 | 2021-04-06 | Ethicon Llc | Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments |
US10980537B2 (en) | 2017-06-20 | 2021-04-20 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations |
US10980539B2 (en) | 2015-09-30 | 2021-04-20 | Ethicon Llc | Implantable adjunct comprising bonded layers |
US10987102B2 (en) | 2010-09-30 | 2021-04-27 | Ethicon Llc | Tissue thickness compensator comprising a plurality of layers |
USD917500S1 (en) | 2017-09-29 | 2021-04-27 | Ethicon Llc | Display screen or portion thereof with graphical user interface |
US10993716B2 (en) | 2017-06-27 | 2021-05-04 | Ethicon Llc | Surgical anvil arrangements |
US11006955B2 (en) | 2017-12-15 | 2021-05-18 | Ethicon Llc | End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments |
US11012599B2 (en) | 2019-06-20 | 2021-05-18 | Ethicon Llc | Hyperspectral imaging in a light deficient environment |
US11007022B2 (en) | 2017-06-29 | 2021-05-18 | Ethicon Llc | Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument |
US11007004B2 (en) | 2012-06-28 | 2021-05-18 | Ethicon Llc | Powered multi-axial articulable electrosurgical device with external dissection features |
US11013511B2 (en) | 2007-06-22 | 2021-05-25 | Ethicon Llc | Surgical stapling instrument with an articulatable end effector |
US11020112B2 (en) | 2017-12-19 | 2021-06-01 | Ethicon Llc | Surgical tools configured for interchangeable use with different controller interfaces |
US11033267B2 (en) | 2017-12-15 | 2021-06-15 | Ethicon Llc | Systems and methods of controlling a clamping member firing rate of a surgical instrument |
US11039834B2 (en) | 2018-08-20 | 2021-06-22 | Cilag Gmbh International | Surgical stapler anvils with staple directing protrusions and tissue stability features |
US11039836B2 (en) | 2007-01-11 | 2021-06-22 | Cilag Gmbh International | Staple cartridge for use with a surgical stapling instrument |
US11045192B2 (en) | 2018-08-20 | 2021-06-29 | Cilag Gmbh International | Fabricating techniques for surgical stapler anvils |
US11045270B2 (en) | 2017-12-19 | 2021-06-29 | Cilag Gmbh International | Robotic attachment comprising exterior drive actuator |
US11051813B2 (en) | 2006-01-31 | 2021-07-06 | Cilag Gmbh International | Powered surgical instruments with firing system lockout arrangements |
US11051807B2 (en) | 2019-06-28 | 2021-07-06 | Cilag Gmbh International | Packaging assembly including a particulate trap |
US11071543B2 (en) | 2017-12-15 | 2021-07-27 | Cilag Gmbh International | Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges |
US11071554B2 (en) | 2017-06-20 | 2021-07-27 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements |
US11071545B2 (en) | 2014-09-05 | 2021-07-27 | Cilag Gmbh International | Smart cartridge wake up operation and data retention |
US11076853B2 (en) | 2017-12-21 | 2021-08-03 | Cilag Gmbh International | Systems and methods of displaying a knife position during transection for a surgical instrument |
US11083458B2 (en) | 2018-08-20 | 2021-08-10 | Cilag Gmbh International | Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions |
US11090075B2 (en) | 2017-10-30 | 2021-08-17 | Cilag Gmbh International | Articulation features for surgical end effector |
US11090046B2 (en) | 2017-06-20 | 2021-08-17 | Cilag Gmbh International | Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument |
US11129680B2 (en) | 2017-12-21 | 2021-09-28 | Cilag Gmbh International | Surgical instrument comprising a projector |
US11133106B2 (en) | 2013-08-23 | 2021-09-28 | Cilag Gmbh International | Surgical instrument assembly comprising a retraction assembly |
US11134942B2 (en) | 2016-12-21 | 2021-10-05 | Cilag Gmbh International | Surgical stapling instruments and staple-forming anvils |
US11134944B2 (en) | 2017-10-30 | 2021-10-05 | Cilag Gmbh International | Surgical stapler knife motion controls |
US11135444B2 (en) * | 2012-11-01 | 2021-10-05 | Seminex Corporation | Variable intensity laser treatments of the skin |
US11141153B2 (en) | 2014-10-29 | 2021-10-12 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
US11147553B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11147551B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11154301B2 (en) | 2015-02-27 | 2021-10-26 | Cilag Gmbh International | Modular stapling assembly |
US11172929B2 (en) | 2019-03-25 | 2021-11-16 | Cilag Gmbh International | Articulation drive arrangements for surgical systems |
US11179150B2 (en) | 2016-04-15 | 2021-11-23 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US11197671B2 (en) | 2012-06-28 | 2021-12-14 | Cilag Gmbh International | Stapling assembly comprising a lockout |
US11197670B2 (en) | 2017-12-15 | 2021-12-14 | Cilag Gmbh International | Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed |
US11202633B2 (en) | 2014-09-26 | 2021-12-21 | Cilag Gmbh International | Surgical stapling buttresses and adjunct materials |
US11207064B2 (en) | 2011-05-27 | 2021-12-28 | Cilag Gmbh International | Automated end effector component reloading system for use with a robotic system |
US11207065B2 (en) | 2018-08-20 | 2021-12-28 | Cilag Gmbh International | Method for fabricating surgical stapler anvils |
US11213293B2 (en) | 2016-02-09 | 2022-01-04 | Cilag Gmbh International | Articulatable surgical instruments with single articulation link arrangements |
US11219455B2 (en) | 2019-06-28 | 2022-01-11 | Cilag Gmbh International | Surgical instrument including a lockout key |
US11224428B2 (en) | 2016-12-21 | 2022-01-18 | Cilag Gmbh International | Surgical stapling systems |
US11224497B2 (en) | 2019-06-28 | 2022-01-18 | Cilag Gmbh International | Surgical systems with multiple RFID tags |
US11224426B2 (en) | 2016-02-12 | 2022-01-18 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US11224423B2 (en) | 2015-03-06 | 2022-01-18 | Cilag Gmbh International | Smart sensors with local signal processing |
US11224427B2 (en) | 2006-01-31 | 2022-01-18 | Cilag Gmbh International | Surgical stapling system including a console and retraction assembly |
US11229437B2 (en) | 2019-06-28 | 2022-01-25 | Cilag Gmbh International | Method for authenticating the compatibility of a staple cartridge with a surgical instrument |
US11234698B2 (en) | 2019-12-19 | 2022-02-01 | Cilag Gmbh International | Stapling system comprising a clamp lockout and a firing lockout |
US11241230B2 (en) | 2012-06-28 | 2022-02-08 | Cilag Gmbh International | Clip applier tool for use with a robotic surgical system |
US11246590B2 (en) | 2005-08-31 | 2022-02-15 | Cilag Gmbh International | Staple cartridge including staple drivers having different unfired heights |
US11246678B2 (en) | 2019-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical stapling system having a frangible RFID tag |
US11246592B2 (en) | 2017-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical instrument comprising an articulation system lockable to a frame |
US11253254B2 (en) | 2019-04-30 | 2022-02-22 | Cilag Gmbh International | Shaft rotation actuator on a surgical instrument |
US11253256B2 (en) | 2018-08-20 | 2022-02-22 | Cilag Gmbh International | Articulatable motor powered surgical instruments with dedicated articulation motor arrangements |
US11259799B2 (en) | 2014-03-26 | 2022-03-01 | Cilag Gmbh International | Interface systems for use with surgical instruments |
US11259805B2 (en) | 2017-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical instrument comprising firing member supports |
US11259803B2 (en) | 2019-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical stapling system having an information encryption protocol |
US11266405B2 (en) | 2017-06-27 | 2022-03-08 | Cilag Gmbh International | Surgical anvil manufacturing methods |
US11266409B2 (en) | 2014-04-16 | 2022-03-08 | Cilag Gmbh International | Fastener cartridge comprising a sled including longitudinally-staggered ramps |
US11272927B2 (en) | 2008-02-15 | 2022-03-15 | Cilag Gmbh International | Layer arrangements for surgical staple cartridges |
US11278279B2 (en) | 2006-01-31 | 2022-03-22 | Cilag Gmbh International | Surgical instrument assembly |
US11284898B2 (en) | 2014-09-18 | 2022-03-29 | Cilag Gmbh International | Surgical instrument including a deployable knife |
US11291451B2 (en) | 2019-06-28 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with battery compatibility verification functionality |
US11291449B2 (en) | 2009-12-24 | 2022-04-05 | Cilag Gmbh International | Surgical cutting instrument that analyzes tissue thickness |
US11291447B2 (en) | 2019-12-19 | 2022-04-05 | Cilag Gmbh International | Stapling instrument comprising independent jaw closing and staple firing systems |
US11291441B2 (en) | 2007-01-10 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with wireless communication between control unit and remote sensor |
US11291440B2 (en) | 2018-08-20 | 2022-04-05 | Cilag Gmbh International | Method for operating a powered articulatable surgical instrument |
US11298132B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Inlernational | Staple cartridge including a honeycomb extension |
US11298125B2 (en) | 2010-09-30 | 2022-04-12 | Cilag Gmbh International | Tissue stapler having a thickness compensator |
US11298127B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Interational | Surgical stapling system having a lockout mechanism for an incompatible cartridge |
US11304695B2 (en) | 2017-08-03 | 2022-04-19 | Cilag Gmbh International | Surgical system shaft interconnection |
US11304696B2 (en) | 2019-12-19 | 2022-04-19 | Cilag Gmbh International | Surgical instrument comprising a powered articulation system |
US11311294B2 (en) | 2014-09-05 | 2022-04-26 | Cilag Gmbh International | Powered medical device including measurement of closure state of jaws |
US11311290B2 (en) | 2017-12-21 | 2022-04-26 | Cilag Gmbh International | Surgical instrument comprising an end effector dampener |
US11317917B2 (en) | 2016-04-18 | 2022-05-03 | Cilag Gmbh International | Surgical stapling system comprising a lockable firing assembly |
US11317913B2 (en) | 2016-12-21 | 2022-05-03 | Cilag Gmbh International | Lockout arrangements for surgical end effectors and replaceable tool assemblies |
US11324503B2 (en) | 2017-06-27 | 2022-05-10 | Cilag Gmbh International | Surgical firing member arrangements |
US11324501B2 (en) | 2018-08-20 | 2022-05-10 | Cilag Gmbh International | Surgical stapling devices with improved closure members |
US11350928B2 (en) | 2016-04-18 | 2022-06-07 | Cilag Gmbh International | Surgical instrument comprising a tissue thickness lockout and speed control system |
US11376098B2 (en) | 2019-06-28 | 2022-07-05 | Cilag Gmbh International | Surgical instrument system comprising an RFID system |
US11382627B2 (en) | 2014-04-16 | 2022-07-12 | Cilag Gmbh International | Surgical stapling assembly comprising a firing member including a lateral extension |
US11382638B2 (en) | 2017-06-20 | 2022-07-12 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance |
US11399829B2 (en) | 2017-09-29 | 2022-08-02 | Cilag Gmbh International | Systems and methods of initiating a power shutdown mode for a surgical instrument |
US11399837B2 (en) | 2019-06-28 | 2022-08-02 | Cilag Gmbh International | Mechanisms for motor control adjustments of a motorized surgical instrument |
US11419606B2 (en) | 2016-12-21 | 2022-08-23 | Cilag Gmbh International | Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems |
US11426251B2 (en) | 2019-04-30 | 2022-08-30 | Cilag Gmbh International | Articulation directional lights on a surgical instrument |
US11426167B2 (en) | 2019-06-28 | 2022-08-30 | Cilag Gmbh International | Mechanisms for proper anvil attachment surgical stapling head assembly |
US11432816B2 (en) | 2019-04-30 | 2022-09-06 | Cilag Gmbh International | Articulation pin for a surgical instrument |
US11446029B2 (en) | 2019-12-19 | 2022-09-20 | Cilag Gmbh International | Staple cartridge comprising projections extending from a curved deck surface |
US11452526B2 (en) | 2020-10-29 | 2022-09-27 | Cilag Gmbh International | Surgical instrument comprising a staged voltage regulation start-up system |
US11452528B2 (en) | 2019-04-30 | 2022-09-27 | Cilag Gmbh International | Articulation actuators for a surgical instrument |
USD966512S1 (en) | 2020-06-02 | 2022-10-11 | Cilag Gmbh International | Staple cartridge |
US11464513B2 (en) | 2012-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument system including replaceable end effectors |
US11464601B2 (en) | 2019-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument comprising an RFID system for tracking a movable component |
US11464512B2 (en) | 2019-12-19 | 2022-10-11 | Cilag Gmbh International | Staple cartridge comprising a curved deck surface |
US11471155B2 (en) | 2017-08-03 | 2022-10-18 | Cilag Gmbh International | Surgical system bailout |
USD967421S1 (en) | 2020-06-02 | 2022-10-18 | Cilag Gmbh International | Staple cartridge |
US11471157B2 (en) | 2019-04-30 | 2022-10-18 | Cilag Gmbh International | Articulation control mapping for a surgical instrument |
US11478241B2 (en) | 2019-06-28 | 2022-10-25 | Cilag Gmbh International | Staple cartridge including projections |
US11478247B2 (en) | 2010-07-30 | 2022-10-25 | Cilag Gmbh International | Tissue acquisition arrangements and methods for surgical stapling devices |
US11484312B2 (en) | 2005-08-31 | 2022-11-01 | Cilag Gmbh International | Staple cartridge comprising a staple driver arrangement |
US11497492B2 (en) | 2019-06-28 | 2022-11-15 | Cilag Gmbh International | Surgical instrument including an articulation lock |
US11504122B2 (en) | 2019-12-19 | 2022-11-22 | Cilag Gmbh International | Surgical instrument comprising a nested firing member |
US11517390B2 (en) | 2020-10-29 | 2022-12-06 | Cilag Gmbh International | Surgical instrument comprising a limited travel switch |
US11517325B2 (en) | 2017-06-20 | 2022-12-06 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval |
US11523821B2 (en) | 2014-09-26 | 2022-12-13 | Cilag Gmbh International | Method for creating a flexible staple line |
US11523822B2 (en) | 2019-06-28 | 2022-12-13 | Cilag Gmbh International | Battery pack including a circuit interrupter |
US11523823B2 (en) | 2016-02-09 | 2022-12-13 | Cilag Gmbh International | Surgical instruments with non-symmetrical articulation arrangements |
US11533417B2 (en) | 2019-06-20 | 2022-12-20 | Cilag Gmbh International | Laser scanning and tool tracking imaging in a light deficient environment |
US11529139B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Motor driven surgical instrument |
US11529137B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11534259B2 (en) | 2020-10-29 | 2022-12-27 | Cilag Gmbh International | Surgical instrument comprising an articulation indicator |
USD974560S1 (en) | 2020-06-02 | 2023-01-03 | Cilag Gmbh International | Staple cartridge |
USD975278S1 (en) | 2020-06-02 | 2023-01-10 | Cilag Gmbh International | Staple cartridge |
US11553971B2 (en) | 2019-06-28 | 2023-01-17 | Cilag Gmbh International | Surgical RFID assemblies for display and communication |
USD975850S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD975851S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD976401S1 (en) | 2020-06-02 | 2023-01-24 | Cilag Gmbh International | Staple cartridge |
US11559304B2 (en) | 2019-12-19 | 2023-01-24 | Cilag Gmbh International | Surgical instrument comprising a rapid closure mechanism |
US11564682B2 (en) | 2007-06-04 | 2023-01-31 | Cilag Gmbh International | Surgical stapler device |
US11564686B2 (en) | 2017-06-28 | 2023-01-31 | Cilag Gmbh International | Surgical shaft assemblies with flexible interfaces |
US11571215B2 (en) | 2010-09-30 | 2023-02-07 | Cilag Gmbh International | Layer of material for a surgical end effector |
US11576672B2 (en) | 2019-12-19 | 2023-02-14 | Cilag Gmbh International | Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw |
USD980425S1 (en) | 2020-10-29 | 2023-03-07 | Cilag Gmbh International | Surgical instrument assembly |
US11607239B2 (en) | 2016-04-15 | 2023-03-21 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US11607219B2 (en) | 2019-12-19 | 2023-03-21 | Cilag Gmbh International | Staple cartridge comprising a detachable tissue cutting knife |
US11617577B2 (en) | 2020-10-29 | 2023-04-04 | Cilag Gmbh International | Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable |
US11622763B2 (en) | 2013-04-16 | 2023-04-11 | Cilag Gmbh International | Stapling assembly comprising a shiftable drive |
US11622766B2 (en) | 2012-06-28 | 2023-04-11 | Cilag Gmbh International | Empty clip cartridge lockout |
US11627959B2 (en) | 2019-06-28 | 2023-04-18 | Cilag Gmbh International | Surgical instruments including manual and powered system lockouts |
US11627960B2 (en) | 2020-12-02 | 2023-04-18 | Cilag Gmbh International | Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections |
US11638582B2 (en) | 2020-07-28 | 2023-05-02 | Cilag Gmbh International | Surgical instruments with torsion spine drive arrangements |
US11638587B2 (en) | 2019-06-28 | 2023-05-02 | Cilag Gmbh International | RFID identification systems for surgical instruments |
US11648005B2 (en) | 2008-09-23 | 2023-05-16 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
US11648009B2 (en) | 2019-04-30 | 2023-05-16 | Cilag Gmbh International | Rotatable jaw tip for a surgical instrument |
US11653920B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Powered surgical instruments with communication interfaces through sterile barrier |
US11653915B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Surgical instruments with sled location detection and adjustment features |
US11653914B2 (en) | 2017-06-20 | 2023-05-23 | Cilag Gmbh International | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector |
US11660163B2 (en) | 2019-06-28 | 2023-05-30 | Cilag Gmbh International | Surgical system with RFID tags for updating motor assembly parameters |
US11678877B2 (en) | 2014-12-18 | 2023-06-20 | Cilag Gmbh International | Surgical instrument including a flexible support configured to support a flexible firing member |
US11678882B2 (en) | 2020-12-02 | 2023-06-20 | Cilag Gmbh International | Surgical instruments with interactive features to remedy incidental sled movements |
US11684434B2 (en) | 2019-06-28 | 2023-06-27 | Cilag Gmbh International | Surgical RFID assemblies for instrument operational setting control |
US11696757B2 (en) | 2021-02-26 | 2023-07-11 | Cilag Gmbh International | Monitoring of internal systems to detect and track cartridge motion status |
US11696761B2 (en) | 2019-03-25 | 2023-07-11 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11701111B2 (en) | 2019-12-19 | 2023-07-18 | Cilag Gmbh International | Method for operating a surgical stapling instrument |
US11701113B2 (en) | 2021-02-26 | 2023-07-18 | Cilag Gmbh International | Stapling instrument comprising a separate power antenna and a data transfer antenna |
US11717289B2 (en) | 2020-10-29 | 2023-08-08 | Cilag Gmbh International | Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable |
US11717291B2 (en) | 2021-03-22 | 2023-08-08 | Cilag Gmbh International | Staple cartridge comprising staples configured to apply different tissue compression |
US11717294B2 (en) | 2014-04-16 | 2023-08-08 | Cilag Gmbh International | End effector arrangements comprising indicators |
US11723658B2 (en) | 2021-03-22 | 2023-08-15 | Cilag Gmbh International | Staple cartridge comprising a firing lockout |
US11723662B2 (en) | 2021-05-28 | 2023-08-15 | Cilag Gmbh International | Stapling instrument comprising an articulation control display |
US11723657B2 (en) | 2021-02-26 | 2023-08-15 | Cilag Gmbh International | Adjustable communication based on available bandwidth and power capacity |
US11730473B2 (en) | 2021-02-26 | 2023-08-22 | Cilag Gmbh International | Monitoring of manufacturing life-cycle |
US11737749B2 (en) | 2021-03-22 | 2023-08-29 | Cilag Gmbh International | Surgical stapling instrument comprising a retraction system |
US11737751B2 (en) | 2020-12-02 | 2023-08-29 | Cilag Gmbh International | Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings |
US11749877B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Stapling instrument comprising a signal antenna |
US11744581B2 (en) | 2020-12-02 | 2023-09-05 | Cilag Gmbh International | Powered surgical instruments with multi-phase tissue treatment |
US11744603B2 (en) | 2021-03-24 | 2023-09-05 | Cilag Gmbh International | Multi-axis pivot joints for surgical instruments and methods for manufacturing same |
US11744583B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Distal communication array to tune frequency of RF systems |
US11751869B2 (en) | 2021-02-26 | 2023-09-12 | Cilag Gmbh International | Monitoring of multiple sensors over time to detect moving characteristics of tissue |
US11758256B2 (en) | 2019-06-20 | 2023-09-12 | Cilag Gmbh International | Fluorescence imaging in a light deficient environment |
US11759202B2 (en) | 2021-03-22 | 2023-09-19 | Cilag Gmbh International | Staple cartridge comprising an implantable layer |
US11766259B2 (en) | 2016-12-21 | 2023-09-26 | Cilag Gmbh International | Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument |
US11766260B2 (en) | 2016-12-21 | 2023-09-26 | Cilag Gmbh International | Methods of stapling tissue |
US11771419B2 (en) | 2019-06-28 | 2023-10-03 | Cilag Gmbh International | Packaging for a replaceable component of a surgical stapling system |
US11779330B2 (en) | 2020-10-29 | 2023-10-10 | Cilag Gmbh International | Surgical instrument comprising a jaw alignment system |
US11786239B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Surgical instrument articulation joint arrangements comprising multiple moving linkage features |
US11786243B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Firing members having flexible portions for adapting to a load during a surgical firing stroke |
US11793516B2 (en) | 2021-03-24 | 2023-10-24 | Cilag Gmbh International | Surgical staple cartridge comprising longitudinal support beam |
US11793518B2 (en) | 2006-01-31 | 2023-10-24 | Cilag Gmbh International | Powered surgical instruments with firing system lockout arrangements |
US11793522B2 (en) | 2015-09-30 | 2023-10-24 | Cilag Gmbh International | Staple cartridge assembly including a compressible adjunct |
US11793514B2 (en) | 2021-02-26 | 2023-10-24 | Cilag Gmbh International | Staple cartridge comprising sensor array which may be embedded in cartridge body |
US11806011B2 (en) | 2021-03-22 | 2023-11-07 | Cilag Gmbh International | Stapling instrument comprising tissue compression systems |
US11812964B2 (en) | 2021-02-26 | 2023-11-14 | Cilag Gmbh International | Staple cartridge comprising a power management circuit |
US11826012B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising a pulsed motor-driven firing rack |
US11826132B2 (en) | 2015-03-06 | 2023-11-28 | Cilag Gmbh International | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US11826048B2 (en) | 2017-06-28 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising selectively actuatable rotatable couplers |
US11826042B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising a firing drive including a selectable leverage mechanism |
US11832816B2 (en) | 2021-03-24 | 2023-12-05 | Cilag Gmbh International | Surgical stapling assembly comprising nonplanar staples and planar staples |
US11844518B2 (en) | 2020-10-29 | 2023-12-19 | Cilag Gmbh International | Method for operating a surgical instrument |
US11844520B2 (en) | 2019-12-19 | 2023-12-19 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11849945B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Rotary-driven surgical stapling assembly comprising eccentrically driven firing member |
US11849941B2 (en) | 2007-06-29 | 2023-12-26 | Cilag Gmbh International | Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis |
US11849944B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Drivers for fastener cartridge assemblies having rotary drive screws |
US11849943B2 (en) | 2020-12-02 | 2023-12-26 | Cilag Gmbh International | Surgical instrument with cartridge release mechanisms |
US11849952B2 (en) | 2010-09-30 | 2023-12-26 | Cilag Gmbh International | Staple cartridge comprising staples positioned within a compressible portion thereof |
US11857183B2 (en) | 2021-03-24 | 2024-01-02 | Cilag Gmbh International | Stapling assembly components having metal substrates and plastic bodies |
US11877745B2 (en) | 2021-10-18 | 2024-01-23 | Cilag Gmbh International | Surgical stapling assembly having longitudinally-repeating staple leg clusters |
US11883026B2 (en) | 2014-04-16 | 2024-01-30 | Cilag Gmbh International | Fastener cartridge assemblies and staple retainer cover arrangements |
USD1013170S1 (en) | 2020-10-29 | 2024-01-30 | Cilag Gmbh International | Surgical instrument assembly |
US11890012B2 (en) | 2004-07-28 | 2024-02-06 | Cilag Gmbh International | Staple cartridge comprising cartridge body and attached support |
US11890010B2 (en) | 2020-12-02 | 2024-02-06 | Cllag GmbH International | Dual-sided reinforced reload for surgical instruments |
US11896219B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Mating features between drivers and underside of a cartridge deck |
US11896217B2 (en) | 2020-10-29 | 2024-02-13 | Cilag Gmbh International | Surgical instrument comprising an articulation lock |
US11896218B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Method of using a powered stapling device |
US11903582B2 (en) | 2021-03-24 | 2024-02-20 | Cilag Gmbh International | Leveraging surfaces for cartridge installation |
US11903581B2 (en) | 2019-04-30 | 2024-02-20 | Cilag Gmbh International | Methods for stapling tissue using a surgical instrument |
US11911032B2 (en) | 2019-12-19 | 2024-02-27 | Cilag Gmbh International | Staple cartridge comprising a seating cam |
US11925349B2 (en) | 2021-02-26 | 2024-03-12 | Cilag Gmbh International | Adjustment to transfer parameters to improve available power |
US11931033B2 (en) | 2019-12-19 | 2024-03-19 | Cilag Gmbh International | Staple cartridge comprising a latch lockout |
US11931025B2 (en) | 2020-10-29 | 2024-03-19 | Cilag Gmbh International | Surgical instrument comprising a releasable closure drive lock |
US11937784B2 (en) | 2019-06-20 | 2024-03-26 | Cilag Gmbh International | Fluorescence imaging in a light deficient environment |
US11937816B2 (en) | 2021-10-28 | 2024-03-26 | Cilag Gmbh International | Electrical lead arrangements for surgical instruments |
US11944336B2 (en) | 2021-03-24 | 2024-04-02 | Cilag Gmbh International | Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments |
US11944338B2 (en) | 2015-03-06 | 2024-04-02 | Cilag Gmbh International | Multiple level thresholds to modify operation of powered surgical instruments |
US11944296B2 (en) | 2020-12-02 | 2024-04-02 | Cilag Gmbh International | Powered surgical instruments with external connectors |
US11944300B2 (en) | 2017-08-03 | 2024-04-02 | Cilag Gmbh International | Method for operating a surgical system bailout |
US11950779B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Method of powering and communicating with a staple cartridge |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10463541B2 (en) | 2011-03-25 | 2019-11-05 | Lensar, Inc. | System and method for correcting astigmatism using multiple paired arcuate laser generated corneal incisions |
JP2014061057A (en) * | 2012-09-20 | 2014-04-10 | Sony Corp | Information processor, information processing method, program, and measurement system |
US9799948B2 (en) | 2015-10-30 | 2017-10-24 | Essential Products, Inc. | Optically transmissive antenna break structures for wireless devices, and associated systems and processes |
US11517373B2 (en) * | 2016-12-27 | 2022-12-06 | Alma Lasers Ltd. | Switched lasers for dermal treatment |
US10625093B2 (en) * | 2018-06-20 | 2020-04-21 | Omm Imports, Inc. | Therapeutic device providing heat and light and head assembly for same |
DE102018118912A1 (en) * | 2018-08-03 | 2020-02-06 | Osram Opto Semiconductors Gmbh | Irradiation device and method for operating an irradiation device |
CN110151307B (en) * | 2019-06-28 | 2020-10-30 | 北京康鼎医疗科技有限公司 | Laser depilatory hand tool |
Citations (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US449528A (en) * | 1891-03-31 | Fence | ||
US3307533A (en) * | 1963-11-26 | 1967-03-07 | Meredith | Apparatus for generating and controlling pressure |
US3821510A (en) * | 1973-02-22 | 1974-06-28 | H Muncheryan | Hand held laser instrumentation device |
US4140130A (en) * | 1977-05-31 | 1979-02-20 | Storm Iii Frederick K | Electrode structure for radio frequency localized heating of tumor bearing tissue |
US4388924A (en) * | 1981-05-21 | 1983-06-21 | Weissman Howard R | Method for laser depilation |
US4423736A (en) * | 1981-10-13 | 1984-01-03 | Purdue Research Foundation | Method for evaluation of erythema utilizing skin reflectance measurements |
US4573466A (en) * | 1981-05-29 | 1986-03-04 | Hitachi, Ltd. | Surgical equipment |
US4592353A (en) * | 1984-05-22 | 1986-06-03 | Surgical Laser Technologies Ohio, Inc. | Medical and surgical laser probe |
US4733660A (en) * | 1984-08-07 | 1988-03-29 | Medical Laser Research And Development Corporation | Laser system for providing target specific energy deposition and damage |
US4829262A (en) * | 1984-10-25 | 1989-05-09 | Candela Laser Corporation | Long pulse tunable light amplifier |
US4905690A (en) * | 1986-06-30 | 1990-03-06 | Medical Laser Research Co., Ltd. | Semiconductor laser treatment device |
US4930504A (en) * | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
US5107832A (en) * | 1991-03-11 | 1992-04-28 | Raul Guibert | Universal thermotherapy applicator |
US5109465A (en) * | 1990-01-16 | 1992-04-28 | Summit Technology, Inc. | Beam homogenizer |
US5282797A (en) * | 1989-05-30 | 1994-02-01 | Cyrus Chess | Method for treating cutaneous vascular lesions |
US5295052A (en) * | 1992-10-09 | 1994-03-15 | Luxtec Corporation | Light source assembly |
US5401270A (en) * | 1990-12-19 | 1995-03-28 | Carl-Zeiss-Stiftung | Applicator device for laser radiation |
US5405368A (en) * | 1992-10-20 | 1995-04-11 | Esc Inc. | Method and apparatus for therapeutic electromagnetic treatment |
US5425728A (en) * | 1991-10-29 | 1995-06-20 | Tankovich; Nicolai I. | Hair removal device and method |
US5481385A (en) * | 1993-07-01 | 1996-01-02 | Alliedsignal Inc. | Direct view display device with array of tapered waveguide on viewer side |
US5486172A (en) * | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US5519534A (en) * | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
US5595568A (en) * | 1995-02-01 | 1997-01-21 | The General Hospital Corporation | Permanent hair removal using optical pulses |
US5606798A (en) * | 1991-03-12 | 1997-03-04 | Kelman; Elliot | Hair cutting apparatus |
US5624435A (en) * | 1995-06-05 | 1997-04-29 | Cynosure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US5628744A (en) * | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
US5630811A (en) * | 1996-03-25 | 1997-05-20 | Miller; Iain D. | Method and apparatus for hair removal |
US5632741A (en) * | 1995-01-20 | 1997-05-27 | Lucid Technologies, Inc. | Epilation system |
US5707403A (en) * | 1993-02-24 | 1998-01-13 | Star Medical Technologies, Inc. | Method for the laser treatment of subsurface blood vessels |
US5728090A (en) * | 1995-02-09 | 1998-03-17 | Quantum Devices, Inc. | Apparatus for irradiating living cells |
US5735844A (en) * | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5743901A (en) * | 1996-05-15 | 1998-04-28 | Star Medical Technologies, Inc. | High fluence diode laser device and method for the fabrication and use thereof |
US5752949A (en) * | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US5752948A (en) * | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US5766214A (en) * | 1996-04-18 | 1998-06-16 | Mehl, Sr.; Thomas L. | Melanin enhanced photothermolysis hair removal |
US5769844A (en) * | 1991-06-26 | 1998-06-23 | Ghaffari; Shahriar | Conventional light-pumped high power system for medical applications |
US5868732A (en) * | 1996-05-12 | 1999-02-09 | Esc Medical Systems, Ltd. | Cooling apparatus for cutaneous treatment employing a laser and method for operating same |
US5871479A (en) * | 1996-11-07 | 1999-02-16 | Cynosure, Inc. | Alexandrite laser system for hair removal and method therefor |
US5871480A (en) * | 1991-10-29 | 1999-02-16 | Thermolase Corporation | Hair removal using photosensitizer and laser |
US5871521A (en) * | 1995-08-25 | 1999-02-16 | Matsushita Electric Industrial Co., Ltd. | Laser probe for medical treatment |
US5879346A (en) * | 1995-12-18 | 1999-03-09 | Esc Medical Systems, Ltd. | Hair removal by selective photothermolysis with an alexandrite laser |
US5885273A (en) * | 1995-03-29 | 1999-03-23 | Esc Medical Systems, Ltd. | Method for depilation using pulsed electromagnetic radiation |
US6015404A (en) * | 1996-12-02 | 2000-01-18 | Palomar Medical Technologies, Inc. | Laser dermatology with feedback control |
USRE36634E (en) * | 1991-12-12 | 2000-03-28 | Ghaffari; Shahriar | Optical system for treatment of vascular lesions |
US6059765A (en) * | 1998-02-26 | 2000-05-09 | Allergan Sales, Inc. | Fluid management system with vertex chamber |
US6072551A (en) * | 1996-02-14 | 2000-06-06 | Physical Optics Corporation | Backlight apparatus for illuminating a display with controlled light output characteristics |
US6080146A (en) * | 1998-02-24 | 2000-06-27 | Altshuler; Gregory | Method and apparatus for hair removal |
US6168831B1 (en) * | 1998-05-22 | 2001-01-02 | Hyundai Electronics America | Apparatus for differential zone lubrication of magnetic recording media and related methods |
US6171301B1 (en) * | 1994-04-05 | 2001-01-09 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery |
US6183773B1 (en) * | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6183500B1 (en) * | 1998-12-03 | 2001-02-06 | Sli Lichtsysteme Gmbh | Process and apparatus for the cosmetic treatment of acne vulgaris |
US6188495B1 (en) * | 1996-11-25 | 2001-02-13 | Sony Corporation | Optical transmission-reception apparatus |
US6197020B1 (en) * | 1996-08-12 | 2001-03-06 | Sublase, Inc. | Laser apparatus for subsurface cutaneous treatment |
US6208749B1 (en) * | 1997-02-28 | 2001-03-27 | Electro-Optical Sciences, Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
US6228074B1 (en) * | 1998-10-15 | 2001-05-08 | Stephen Almeida | Multiple pulse photo-epilator |
US6251127B1 (en) * | 1997-08-25 | 2001-06-26 | Advanced Photodynamic Technologies, Inc. | Dye treatment solution and photodynamic therapy and method of using same |
US20020005475A1 (en) * | 2000-04-28 | 2002-01-17 | Zenzie Henry H. | Contact detecting method and apparatus for an optical radiation handpiece |
US20020015430A1 (en) * | 2000-05-15 | 2002-02-07 | Lambda Physik Ag | Electrical excitation circuit for a pulsed gas laser |
US20020031160A1 (en) * | 2000-08-04 | 2002-03-14 | Lambda Physik Ag | Delay compensation for magnetic compressors |
US20020049483A1 (en) * | 1996-01-05 | 2002-04-25 | Knowlton Edward W. | Fluid delivery apparatus |
US6379376B1 (en) * | 1996-11-25 | 2002-04-30 | Rachel Lubart | Device for light irradiation onto tissue |
US6408212B1 (en) * | 1999-04-13 | 2002-06-18 | Joseph Neev | Method for treating acne |
US20030004499A1 (en) * | 2000-01-13 | 2003-01-02 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
US20030009158A1 (en) * | 2001-07-09 | 2003-01-09 | Perricone Nicholas V. | Skin treatments using blue and violet light |
US6508813B1 (en) * | 1996-12-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US6511475B1 (en) * | 1997-05-15 | 2003-01-28 | The General Hospital Corporation | Heads for dermatology treatment |
US6516013B1 (en) * | 1999-12-20 | 2003-02-04 | Lambda Physik Ag | Laser beam monitoring apparatus and method |
US6514242B1 (en) * | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
US6517532B1 (en) * | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US20030032950A1 (en) * | 1996-12-02 | 2003-02-13 | Altshuler Gregory B. | Cooling system for a photo cosmetic device |
US20030036751A1 (en) * | 2001-05-30 | 2003-02-20 | Anderson R. Rox | Apparatus and method for laser treatment with spectroscopic feedback |
US20030050561A1 (en) * | 2001-07-09 | 2003-03-13 | L'oreal | System and method for evaluating a characteristic of body typology |
US20030046825A1 (en) * | 2001-04-02 | 2003-03-13 | Slingo Fred M. | Hair dryer employing far infrared radiation and negative ions |
US6533775B1 (en) * | 1999-05-05 | 2003-03-18 | Ioana M. Rizoiu | Light-activated hair treatment and removal device |
US20030055413A1 (en) * | 2001-07-02 | 2003-03-20 | Altshuler Gregory B. | Fiber laser device for medical/cosmetic procedures |
US6536914B2 (en) * | 2000-05-04 | 2003-03-25 | Koninklijke Philips Electronics N.V. | Illumination system, light mixing chamber and display device |
US6548781B1 (en) * | 1999-04-01 | 2003-04-15 | Microlas Lasersystem Gmbh | Means and method for controlling the intensity distribution of a laser beam |
US6563853B2 (en) * | 1999-03-12 | 2003-05-13 | Lambda Physik Ag | Gas performance control system for gas discharge lasers |
US6567696B2 (en) * | 2001-02-06 | 2003-05-20 | Mediseb Ltd. | Physiotherapeutic device |
US20030094714A1 (en) * | 1998-09-25 | 2003-05-22 | Buazza Omar M. | Plastic lens systems and compositions |
US20030105069A1 (en) * | 2001-05-31 | 2003-06-05 | Robinson Byron C. | Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy |
WO2003049633A1 (en) * | 2001-12-10 | 2003-06-19 | Inolase 2002 Ltd. | Method and apparatus for improving safety during exposure to a monochromatic light source |
US20040010299A1 (en) * | 2002-04-16 | 2004-01-15 | Seedling Enterprises, Llc | Chemiluminescent light source using visible light for biotherapy |
US20040010298A1 (en) * | 2001-12-27 | 2004-01-15 | Gregory Altshuler | Method and apparatus for improved vascular related treatment |
US20040034341A1 (en) * | 1998-03-27 | 2004-02-19 | Palomar Medical Technologies, Inc. | Method and apparatus for the selective targeting of lipid-rich tissues |
US20040034319A1 (en) * | 2002-03-12 | 2004-02-19 | Palomar Medical Technologies, Inc. | Method and apparatus for hair growth management |
US20040073079A1 (en) * | 2002-06-19 | 2004-04-15 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
US20040093042A1 (en) * | 2002-06-19 | 2004-05-13 | Palomar Medical Technologies, Inc. | Method and apparatus for photothermal treatment of tissue at depth |
US20040122492A1 (en) * | 1999-07-07 | 2004-06-24 | Yoram Harth | Phototherapeutic treatment of skin conditions |
US20040120151A1 (en) * | 2002-12-20 | 2004-06-24 | Cao Group, Inc. | Forensic light using semiconductor light source |
US20050008049A1 (en) * | 2003-06-03 | 2005-01-13 | Hirotaka Oomori | Optical module including a Peltier device therein and having a co-axial type package |
US6887260B1 (en) * | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US20050107849A1 (en) * | 2001-11-29 | 2005-05-19 | Altshuler Gregory B. | Tissue penetrating oral phototherapy applicator |
US20070027440A1 (en) * | 2001-03-02 | 2007-02-01 | Palomar Medical Technologies, Inc. | Apparatus and method for photocosmetic and photodermatological treatment |
US7452356B2 (en) * | 2003-02-25 | 2008-11-18 | Tria Beauty, Inc. | Eye-safe dermatologic treatment apparatus |
Family Cites Families (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3538919A (en) | 1967-04-07 | 1970-11-10 | Gregory System Inc | Depilation by means of laser energy |
US3622743A (en) | 1969-04-28 | 1971-11-23 | Hrand M Muncheryan | Laser eraser and microwelder |
US3693623A (en) | 1970-12-25 | 1972-09-26 | Gregory System Inc | Photocoagulation means and method for depilation |
US3834391A (en) | 1973-01-19 | 1974-09-10 | Block Carol Ltd | Method and apparatus for photoepilation |
FR2390968A1 (en) | 1977-05-16 | 1978-12-15 | Skovajsa Joseph | Local acupuncture treatment appts. - has oblong head with end aperture and contains laser diode unit (NL 20.11.78) |
JPS5824124B2 (en) | 1978-10-05 | 1983-05-19 | 松下電器産業株式会社 | hair adjustment tool |
US4240738A (en) | 1979-06-14 | 1980-12-23 | Vivitar Corporation | Light mixing system for a photographic enlarger |
US4449528A (en) | 1980-03-20 | 1984-05-22 | University Of Washington | Fast pulse thermal cautery probe and method |
GB2123287B (en) | 1982-07-09 | 1986-03-05 | Anna Gunilla Sutton | Depilaton device |
US4551628A (en) | 1983-04-01 | 1985-11-05 | Mcdonnell Douglas Corporation | Radiation dispersing cavities |
US4608978A (en) | 1983-09-26 | 1986-09-02 | Carol Block Limited | Method and apparatus for photoepiltion |
FR2579884B1 (en) | 1985-04-09 | 1988-12-02 | Sanofi Sa | |
US4690141A (en) | 1985-09-16 | 1987-09-01 | Castel John C | Fresnel lens light applicator |
US5092865A (en) * | 1987-02-27 | 1992-03-03 | Xintec Corporation | Optical fiber fault detector |
US4860744A (en) | 1987-11-02 | 1989-08-29 | Raj K. Anand | Thermoelectrically controlled heat medical catheter |
US5259380A (en) | 1987-11-04 | 1993-11-09 | Amcor Electronics, Ltd. | Light therapy system |
US4849211A (en) | 1988-03-16 | 1989-07-18 | Schrauzer Gerhard N | Product and method for the treatment of acne and other skin disorders |
US5059013A (en) | 1988-08-29 | 1991-10-22 | Kantilal Jain | Illumination system to produce self-luminous light beam of selected cross-section, uniform intensity and selected numerical aperture |
US5846252A (en) | 1989-12-21 | 1998-12-08 | Mehl, Sr.; Thomas L. | Method of removing hair from the body and inhibiting future growth |
US5059192A (en) | 1990-04-24 | 1991-10-22 | Nardo Zaias | Method of hair depilation |
US5071417A (en) | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
FR2665366A1 (en) | 1990-07-10 | 1992-02-07 | Rameil Jean | Apparatus for dermal electrostimulation |
US5075971A (en) | 1990-07-17 | 1991-12-31 | Wahl Clipper Corporation | Methods and apparatus for trimming hair and disposing of hair clippings |
DE4032860A1 (en) | 1990-10-12 | 1992-04-16 | Zeiss Carl Fa | POWER-CONTROLLED CONTACT APPLICATOR FOR LASER RADIATION |
US6390370B1 (en) | 1990-11-15 | 2002-05-21 | Symbol Technologies, Inc. | Light beam scanning pen, scan module for the device and method of utilization |
US5549660A (en) | 1990-11-15 | 1996-08-27 | Amron, Ltd. | Method of treating acne |
JPH04369564A (en) | 1991-04-02 | 1992-12-22 | Eastman Kodak Japan Kk | Light emitting device |
EP1116476A3 (en) | 1991-04-05 | 2001-08-22 | Indigo Medical, Incorporated | Apparatus using a laser lucent needle |
US5817089A (en) | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US5226907A (en) | 1991-10-29 | 1993-07-13 | Tankovich Nikolai I | Hair removal device and method |
US5342404A (en) | 1992-04-03 | 1994-08-30 | Intermedics, Inc. | Implantable medical interventional device |
US6280438B1 (en) * | 1992-10-20 | 2001-08-28 | Esc Medical Systems Ltd. | Method and apparatus for electromagnetic treatment of the skin, including hair depilation |
US5683380A (en) | 1995-03-29 | 1997-11-04 | Esc Medical Systems Ltd. | Method and apparatus for depilation using pulsed electromagnetic radiation |
US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
JPH06273758A (en) | 1993-03-23 | 1994-09-30 | Sanyo Electric Co Ltd | Liquid crystal projector |
JP3397833B2 (en) | 1993-05-18 | 2003-04-21 | 三洋電機株式会社 | LCD projector |
US5647866A (en) | 1993-11-09 | 1997-07-15 | Zaias; Nardo | Method of hair depilation |
US6277111B1 (en) | 1993-12-08 | 2001-08-21 | Icn Photonics Limited | Depilation |
US5591127A (en) | 1994-01-28 | 1997-01-07 | Barwick, Jr.; Billie J. | Phacoemulsification method and apparatus |
US5556612A (en) | 1994-03-15 | 1996-09-17 | The General Hospital Corporation | Methods for phototherapeutic treatment of proliferative skin diseases |
US5464436A (en) | 1994-04-28 | 1995-11-07 | Lasermedics, Inc. | Method of performing laser therapy |
US5473408A (en) | 1994-07-01 | 1995-12-05 | Anvik Corporation | High-efficiency, energy-recycling exposure system |
US5431647A (en) | 1994-07-13 | 1995-07-11 | Pioneer Optics Company | Fiberoptic cylindrical diffuser |
US5662643A (en) | 1994-09-28 | 1997-09-02 | Abiomed R & D, Inc. | Laser welding system |
US5669916A (en) | 1994-09-28 | 1997-09-23 | The General Hospital Corporation | Method of hair removal |
NZ296098A (en) | 1994-11-04 | 2001-05-25 | Polymun Scient Immunbio Forsch | Super oxide dismutase in liposome and it's use in therapy |
US5611798A (en) | 1995-03-02 | 1997-03-18 | Eggers; Philip E. | Resistively heated cutting and coagulating surgical instrument |
US5578022A (en) | 1995-04-12 | 1996-11-26 | Scherson; Daniel A. | Oxygen producing bandage and method |
US6712481B2 (en) | 1995-06-27 | 2004-03-30 | Solid State Opto Limited | Light emitting panel assemblies |
US5658323A (en) | 1995-07-12 | 1997-08-19 | Miller; Iain D. | Method and apparatus for dermatology treatment |
US5849029A (en) | 1995-12-26 | 1998-12-15 | Esc Medical Systems, Ltd. | Method for controlling the thermal profile of the skin |
US5824023A (en) | 1995-10-12 | 1998-10-20 | The General Hospital Corporation | Radiation-delivery device |
US5792137A (en) | 1995-10-27 | 1998-08-11 | Lacar Microsystems, Inc. | Coagulating microsystem |
US7022121B2 (en) | 1999-03-09 | 2006-04-04 | Thermage, Inc. | Handpiece for treatment of tissue |
US7115123B2 (en) | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
US6114862A (en) | 1996-02-14 | 2000-09-05 | Stmicroelectronics, Inc. | Capacitive distance sensor |
KR100376650B1 (en) | 1996-04-09 | 2003-08-25 | 싸이노슈어, 인코포레이티드 | Alexander laser system for the treatment of skin pathological specimens |
US5843072A (en) | 1996-11-07 | 1998-12-01 | Cynosure, Inc. | Method for treatment of unwanted veins and device therefor |
DE19629978A1 (en) | 1996-07-25 | 1998-01-29 | Heinz Renner | Cable-less laser pistol for firearms training |
AU3813897A (en) | 1996-07-25 | 1998-02-20 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
US6106514A (en) | 1996-08-12 | 2000-08-22 | O'donnell, Jr.; Francis E. | Laser method for subsurface cutaneous treatment |
US6214034B1 (en) | 1996-09-04 | 2001-04-10 | Radiancy, Inc. | Method of selective photothermolysis |
JP3036232U (en) | 1996-09-26 | 1997-04-15 | ヤーマン株式会社 | Optical hair removal device |
US8182473B2 (en) * | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US20060149343A1 (en) | 1996-12-02 | 2006-07-06 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US6063108A (en) | 1997-01-06 | 2000-05-16 | Salansky; Norman | Method and apparatus for localized low energy photon therapy (LEPT) |
US6134475A (en) | 1997-01-22 | 2000-10-17 | Will; Frank J. | Therapeutic device |
US5830208A (en) | 1997-01-31 | 1998-11-03 | Laserlite, Llc | Peltier cooled apparatus and methods for dermatological treatment |
US5810801A (en) | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
CA2280739C (en) | 1997-02-13 | 2005-12-06 | Alliedsignal Inc. | Illumination system with light recycling to enhance brightness |
US5966210A (en) | 1997-03-20 | 1999-10-12 | Hartford Hospital | Apparatus for evaluating the performance characteristics of endoscopes |
US6441943B1 (en) | 1997-04-02 | 2002-08-27 | Gentex Corporation | Indicators and illuminators using a semiconductor radiation emitter package |
CA2206203A1 (en) | 1997-05-27 | 1998-11-27 | University Of British Columbia | Photoactivation of endogenous porphyrins for treatment of psoriasis |
US6099520A (en) | 1997-06-10 | 2000-08-08 | Shimoji; Yutaka | Method of using a cordless medical laser to cure composites and sterilize living tissue |
EP1018955A4 (en) | 1997-06-24 | 2001-06-20 | Laser Aesthetics Inc | Pulsed filament lamp for dermatological treatment |
US6142650A (en) | 1997-07-10 | 2000-11-07 | Brown; David C. | Laser flashlight |
US6104959A (en) | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6273885B1 (en) | 1997-08-16 | 2001-08-14 | Cooltouch Corporation | Handheld photoepilation device and method |
US20030133292A1 (en) | 1999-11-18 | 2003-07-17 | Mueller George G. | Methods and apparatus for generating and modulating white light illumination conditions |
DE69834827T2 (en) | 1997-10-08 | 2006-11-16 | The General Hospital Corp., Boston | PHOTOTHERAPEUTIC SYSTEMS |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
JPH11244295A (en) | 1998-03-02 | 1999-09-14 | Osada Res Inst Ltd | Cordless medical semiconductor laser device |
US6095661A (en) | 1998-03-19 | 2000-08-01 | Ppt Vision, Inc. | Method and apparatus for an L.E.D. flashlight |
US6306130B1 (en) | 1998-04-07 | 2001-10-23 | The General Hospital Corporation | Apparatus and methods for removing blood vessels |
US6264649B1 (en) | 1998-04-09 | 2001-07-24 | Ian Andrew Whitcroft | Laser treatment cooling head |
US6428198B1 (en) | 1998-07-07 | 2002-08-06 | Alliedsignal Inc. | Display system having a light source separate from a display device |
WO2000002491A1 (en) | 1998-07-09 | 2000-01-20 | Curelight Ltd. | Apparatus and method for efficient high energy photodynamic therapy of acne vulgaris and seborrhea |
US6322584B2 (en) | 1998-07-31 | 2001-11-27 | Surx, Inc. | Temperature sensing devices and methods to shrink tissues |
US6138041A (en) | 1998-09-23 | 2000-10-24 | Ccm Cellular Connection Of Miami, Inc. | Device for safe use of a portable cellular telephone while driving |
US6160831A (en) | 1998-10-26 | 2000-12-12 | Lambda Physik Gmbh | Wavelength calibration tool for narrow band excimer lasers |
ES2240078T3 (en) | 1999-03-09 | 2005-10-16 | Thermage, Inc. | APPARATUS FOR TREATMENT OF FABRICS. |
JP3188426B2 (en) | 1999-03-12 | 2001-07-16 | ヤーマン株式会社 | Laser irradiation probe |
US6383176B1 (en) | 1999-03-15 | 2002-05-07 | Altus Medical, Inc. | Hair removal device and method |
US6419873B1 (en) | 1999-03-19 | 2002-07-16 | Q2100, Inc. | Plastic lens systems, compositions, and methods |
US6778574B1 (en) * | 1999-04-05 | 2004-08-17 | Sharp Kabushiki Kaisha | Semiconductor laser device and its manufacturing method, and optical communication system and optical sensor system |
JP2000300683A (en) | 1999-04-20 | 2000-10-31 | Shimoji Yutaka | Dental and medical cordless laser and method for sterilizing organ tissue by hardening compound material with using the same |
US20030216795A1 (en) | 1999-07-07 | 2003-11-20 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders |
US20020128695A1 (en) | 1999-07-07 | 2002-09-12 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris and seborrhea |
US20020173833A1 (en) | 1999-07-07 | 2002-11-21 | Avner Korman | Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders |
US6451007B1 (en) | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
US6290713B1 (en) | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
US6406474B1 (en) | 1999-09-30 | 2002-06-18 | Ceramoptec Ind Inc | Device and method for application of radiation |
US6758845B1 (en) | 1999-10-08 | 2004-07-06 | Lumenis Inc. | Automatic firing apparatus and methods for laser skin treatment over large areas |
AU784423B2 (en) | 2000-01-25 | 2006-03-30 | General Hospital Corporation, The | Method and apparatus for medical treatment utilizing long duration electromagnetic radiation |
US20020097587A1 (en) | 2000-02-11 | 2002-07-25 | Krietzman Mark Howard | Variable output laser illuminator and targeting device |
JP2001238968A (en) | 2000-03-01 | 2001-09-04 | Ya Man Ltd | Laser beam irradiation probe |
JP2001252363A (en) | 2000-03-09 | 2001-09-18 | Ya Man Ltd | Laser beam radiating probe |
US6553168B2 (en) | 2000-05-23 | 2003-04-22 | Honeywell International Inc. | Projection system utilizing fiber optic illumination |
CN2442726Y (en) | 2000-06-05 | 2001-08-15 | 罗建平 | Cordless laser gun |
US7083610B1 (en) | 2000-06-07 | 2006-08-01 | Laserscope | Device for irradiating tissue |
US6655810B2 (en) | 2000-06-21 | 2003-12-02 | Fujitsu Display Technologies Corporation | Lighting unit |
US6413268B1 (en) | 2000-08-11 | 2002-07-02 | Raymond A. Hartman | Apparatus and method for targeted UV phototherapy of skin disorders |
DE10044662A1 (en) | 2000-09-09 | 2002-03-21 | Cognis Deutschland Gmbh | Cosmetic or pharmaceutical composition e.g. useful for skin cleansing or acne treatment, comprise salicylic acid, alkyl and/or alkenyl oligoglycosides and alkyl ether sulfates |
AU2002245163A1 (en) | 2000-10-20 | 2002-07-24 | Photomedex | Controlled dose delivery of ultraviolet light for treating skin disorders |
US6637924B2 (en) | 2000-11-15 | 2003-10-28 | Teledyne Lighting And Display Products, Inc. | Strip lighting apparatus and method |
US6733493B2 (en) | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
CA2433022C (en) | 2000-12-28 | 2016-12-06 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic emr treatment of the skin |
JP4027049B2 (en) | 2001-02-28 | 2007-12-26 | 株式会社ニデック | Laser therapy device |
DE10123926A1 (en) | 2001-03-08 | 2002-09-19 | Optomed Optomedical Systems Gmbh | irradiation device |
US20020138071A1 (en) | 2001-03-22 | 2002-09-26 | Angeley David G. | Scanning laser handpiece with shaped output beam |
WO2002078559A1 (en) | 2001-03-30 | 2002-10-10 | Koninklijke Philips Electronics N.V. | Skin treating device comprising a protected radiation exit opening |
CN1463188A (en) | 2001-04-20 | 2003-12-24 | 皇家菲利浦电子有限公司 | Skin treating device with protection against rediation pulse overdose |
JP2004527330A (en) * | 2001-05-23 | 2004-09-09 | パロマー・メディカル・テクノロジーズ・インコーポレーテッド | Cooling system for light cosmetic device |
US6957905B1 (en) | 2001-10-03 | 2005-10-25 | Led Pipe, Inc. | Solid state light source |
JP4035418B2 (en) | 2001-10-31 | 2008-01-23 | 株式会社本田電子技研 | Proximity switch and object detection device |
US6922523B2 (en) | 2001-11-08 | 2005-07-26 | Johnson & Johnson Consumer Companies, Inc. | Method of promoting skin care products |
GB0127581D0 (en) | 2001-11-17 | 2002-01-09 | Univ St Andrews | Therapeutic Light-emitting device |
US6648904B2 (en) | 2001-11-29 | 2003-11-18 | Palomar Medical Technologies, Inc. | Method and apparatus for controlling the temperature of a surface |
US7762964B2 (en) | 2001-12-10 | 2010-07-27 | Candela Corporation | Method and apparatus for improving safety during exposure to a monochromatic light source |
US6860616B2 (en) | 2001-12-14 | 2005-03-01 | Iq Hong Kong, Ltd. | Ultraviolet light writing system |
US6621702B2 (en) | 2002-01-25 | 2003-09-16 | Lockheed Martin Corporation | Method and apparatus for absorbing thermal energy |
US6722498B2 (en) | 2002-02-06 | 2004-04-20 | Salton, Inc. | Integrated storage container for an attachment to a personal grooming tool |
WO2003067217A2 (en) | 2002-02-08 | 2003-08-14 | Integriderm, Inc. | Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays |
US6739071B2 (en) | 2002-03-01 | 2004-05-25 | Andis Company | Combined diffuser and concentrator for a hair dryer |
ES2300399T3 (en) | 2002-04-30 | 2008-06-16 | Cognis Ip Management Gmbh | EMPLOYMENT OF MIXTURES OF ACTIVE PRINCIPLES WITH ACELAIC ACID AND GLYCLRETIC ACID AS ANTI-ACNE AGENTS. |
US20070038206A1 (en) | 2004-12-09 | 2007-02-15 | Palomar Medical Technologies, Inc. | Photocosmetic device |
US20030233138A1 (en) | 2002-06-12 | 2003-12-18 | Altus Medical, Inc. | Concentration of divergent light from light emitting diodes into therapeutic light energy |
JP2003024458A (en) | 2002-06-27 | 2003-01-28 | Ya Man Ltd | Laser beam irradiation probe |
EP1384446A1 (en) | 2002-07-27 | 2004-01-28 | Lux Medico ApS | Hand-held laser for skin treatment |
US6872221B2 (en) | 2002-08-05 | 2005-03-29 | Larry Robert Lytle | Therapeutic low level laser apparatus and method |
US7250047B2 (en) | 2002-08-16 | 2007-07-31 | Lumenis Ltd. | System and method for treating tissue |
CA2495843A1 (en) | 2002-09-04 | 2004-03-18 | Mark Straubhaar | Optoelectronic device for the treatment of muscle or joint pain |
US7084389B2 (en) | 2002-09-11 | 2006-08-01 | Donald Spector | Hand held led device |
EP1543361A1 (en) | 2002-09-18 | 2005-06-22 | Koninklijke Philips Electronics N.V. | Light generating device having polarized light emitting waveguide plate |
JP4212867B2 (en) | 2002-10-21 | 2009-01-21 | ヤーマン株式会社 | Laser treatment equipment |
US20050069566A1 (en) | 2003-08-04 | 2005-03-31 | Foamix Ltd. | Foam carrier containing amphiphilic copolymeric gelling agent |
US20070292461A1 (en) | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US7267673B2 (en) | 2002-12-12 | 2007-09-11 | Pacific Biosciences Laboratories, Inc. | System for treatment of acne skin condition using a narrow band light source |
AU2003301111A1 (en) | 2002-12-20 | 2004-07-22 | Palomar Medical Technologies, Inc. | Apparatus for light treatment of acne and other disorders of follicles |
US20040147985A1 (en) | 2003-01-27 | 2004-07-29 | Altus Medical, Inc. | Dermatological treatment flashlamp device and method |
WO2004075731A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Acne treatment device and method |
US20100069898A1 (en) | 2003-02-25 | 2010-03-18 | Tria Beauty, Inc. | Acne Treatment Method, System and Device |
WO2004075976A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Method and apparatus for the treatment of benign pigmented lesions |
WO2004077020A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Skin sensing method and apparatus |
EP1596745B1 (en) | 2003-02-25 | 2016-02-17 | Tria Beauty, Inc. | Self-contained, diode-laser-based dermatologic treatment apparatus |
US8709003B2 (en) | 2003-02-25 | 2014-04-29 | Tria Beauty, Inc. | Capacitive sensing method and device for detecting skin |
ES2570985T3 (en) | 2003-02-25 | 2016-05-23 | Tria Beauty Inc | Apparatus and procedure for inhibiting new hair growth, safe for the eye and autonomous |
WO2004080279A2 (en) | 2003-03-06 | 2004-09-23 | Spectragenics, Inc. | In the patent cooperation treaty application for patent |
US6869206B2 (en) | 2003-05-23 | 2005-03-22 | Scott Moore Zimmerman | Illumination systems utilizing highly reflective light emitting diodes and light recycling to enhance brightness |
US7531196B2 (en) | 2003-05-30 | 2009-05-12 | Pacific Specialty Oils, Inc. | Cosmeceutical formulation containing palm oils |
US7146084B2 (en) | 2003-06-16 | 2006-12-05 | Cmc Electronics, Inc. | Fiber optic light source for display devices |
US20070042020A1 (en) | 2003-10-30 | 2007-02-22 | Howard James R | Composition for the treatment of dysfunctional energy metabolism syndrome |
JP5146517B2 (en) | 2003-12-16 | 2013-02-20 | 大日本印刷株式会社 | Manufacturing method of organic functional device |
DE10360503A1 (en) | 2003-12-22 | 2005-07-14 | Sanguibiotech Gmbh | Combination set and method for the bio-regenerative treatment of skin |
US20050186168A1 (en) | 2004-02-24 | 2005-08-25 | Albin Eric L. | Skin remodeling and regenerative compositions containing elastin peptide ligands having the amino acid sequence (XGXXPG)n |
JP2005278724A (en) | 2004-03-26 | 2005-10-13 | Ya Man Ltd | Treatment apparatus |
JP4692983B2 (en) | 2004-07-12 | 2011-06-01 | 独立行政法人科学技術振興機構 | Liposomes from which liposome encapsulated material can escape from endosomes |
US7749260B2 (en) | 2004-12-10 | 2010-07-06 | Da Silva Luiz B | Devices and methods for treatment of skin conditions |
JP2006192073A (en) | 2005-01-13 | 2006-07-27 | Matsushita Electric Ind Co Ltd | Phototherapy apparatus |
AU2006214028A1 (en) | 2005-02-18 | 2006-08-24 | Palomar Medical Technologies, Inc. | Dermatological treatment device |
US20070025947A1 (en) | 2005-07-29 | 2007-02-01 | L'oreal | Anti-acne method and kit |
CN101282692A (en) | 2005-08-08 | 2008-10-08 | 帕洛玛医疗技术公司 | Eye-safe photocosmetic device |
CN101309631A (en) | 2005-09-15 | 2008-11-19 | 帕洛玛医疗技术公司 | Skin optical characterization device |
US7988688B2 (en) * | 2006-09-21 | 2011-08-02 | Lockheed Martin Corporation | Miniature apparatus and method for optical stimulation of nerves and other animal tissue |
EP1957109A2 (en) | 2005-12-02 | 2008-08-20 | Sirtris Pharmaceuticals, Inc. | Modulators of cdc2-like kinases (clks) and methods of use thereof |
US8486124B2 (en) | 2006-11-15 | 2013-07-16 | National Biological Corporation | Controlled protocol timer |
KR100853655B1 (en) | 2006-12-15 | 2008-08-25 | 한국전기연구원 | Apparatus, light source system and method for photo-diagnosis and phototherapy of skin disease |
US20090177253A1 (en) | 2008-01-08 | 2009-07-09 | Oregon Aesthetic Technologies | Skin therapy system |
US9687671B2 (en) | 2008-04-25 | 2017-06-27 | Channel Investments, Llc | Optical sensor and method for identifying the presence of skin and the pigmentation of skin |
FR2932679B1 (en) | 2008-06-24 | 2010-08-27 | Oreal | USE OF FERULIC ACID OR DERIVATIVES THEREOF FOR IMPROVING THE SURFACE CONDITION OF AN ALTERNATING SKIN. |
-
2004
- 2004-02-19 EP EP13159309.7A patent/EP2604216B1/en not_active Expired - Lifetime
- 2004-02-19 EP EP13159308.9A patent/EP2604215B1/en not_active Expired - Lifetime
-
2008
- 2008-11-14 US US12/271,819 patent/US20090204109A1/en not_active Abandoned
-
2009
- 2009-11-16 JP JP2009261364A patent/JP2010046518A/en active Pending
-
2013
- 2013-10-07 US US14/047,998 patent/US10342617B2/en active Active
-
2014
- 2014-02-03 US US14/171,592 patent/US10342618B2/en active Active
Patent Citations (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US449528A (en) * | 1891-03-31 | Fence | ||
US3307533A (en) * | 1963-11-26 | 1967-03-07 | Meredith | Apparatus for generating and controlling pressure |
US3821510A (en) * | 1973-02-22 | 1974-06-28 | H Muncheryan | Hand held laser instrumentation device |
US4140130A (en) * | 1977-05-31 | 1979-02-20 | Storm Iii Frederick K | Electrode structure for radio frequency localized heating of tumor bearing tissue |
US4388924A (en) * | 1981-05-21 | 1983-06-21 | Weissman Howard R | Method for laser depilation |
US4573466A (en) * | 1981-05-29 | 1986-03-04 | Hitachi, Ltd. | Surgical equipment |
US4423736A (en) * | 1981-10-13 | 1984-01-03 | Purdue Research Foundation | Method for evaluation of erythema utilizing skin reflectance measurements |
US4592353B1 (en) * | 1984-05-22 | 1989-04-18 | ||
US4592353A (en) * | 1984-05-22 | 1986-06-03 | Surgical Laser Technologies Ohio, Inc. | Medical and surgical laser probe |
US4733660A (en) * | 1984-08-07 | 1988-03-29 | Medical Laser Research And Development Corporation | Laser system for providing target specific energy deposition and damage |
US4829262A (en) * | 1984-10-25 | 1989-05-09 | Candela Laser Corporation | Long pulse tunable light amplifier |
US4905690A (en) * | 1986-06-30 | 1990-03-06 | Medical Laser Research Co., Ltd. | Semiconductor laser treatment device |
US4930504A (en) * | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
US5282797A (en) * | 1989-05-30 | 1994-02-01 | Cyrus Chess | Method for treating cutaneous vascular lesions |
US5486172A (en) * | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US5109465A (en) * | 1990-01-16 | 1992-04-28 | Summit Technology, Inc. | Beam homogenizer |
US5401270A (en) * | 1990-12-19 | 1995-03-28 | Carl-Zeiss-Stiftung | Applicator device for laser radiation |
US5107832A (en) * | 1991-03-11 | 1992-04-28 | Raul Guibert | Universal thermotherapy applicator |
US5606798A (en) * | 1991-03-12 | 1997-03-04 | Kelman; Elliot | Hair cutting apparatus |
US5769844A (en) * | 1991-06-26 | 1998-06-23 | Ghaffari; Shahriar | Conventional light-pumped high power system for medical applications |
US5425728A (en) * | 1991-10-29 | 1995-06-20 | Tankovich; Nicolai I. | Hair removal device and method |
US5752949A (en) * | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US5752948A (en) * | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US5871480A (en) * | 1991-10-29 | 1999-02-16 | Thermolase Corporation | Hair removal using photosensitizer and laser |
USRE36634E (en) * | 1991-12-12 | 2000-03-28 | Ghaffari; Shahriar | Optical system for treatment of vascular lesions |
US5295052A (en) * | 1992-10-09 | 1994-03-15 | Luxtec Corporation | Light source assembly |
US5405368A (en) * | 1992-10-20 | 1995-04-11 | Esc Inc. | Method and apparatus for therapeutic electromagnetic treatment |
US5707403A (en) * | 1993-02-24 | 1998-01-13 | Star Medical Technologies, Inc. | Method for the laser treatment of subsurface blood vessels |
US5481385A (en) * | 1993-07-01 | 1996-01-02 | Alliedsignal Inc. | Direct view display device with array of tapered waveguide on viewer side |
US5628744A (en) * | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
US6171301B1 (en) * | 1994-04-05 | 2001-01-09 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery |
US5519534A (en) * | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
US5632741A (en) * | 1995-01-20 | 1997-05-27 | Lucid Technologies, Inc. | Epilation system |
US5735844A (en) * | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5595568A (en) * | 1995-02-01 | 1997-01-21 | The General Hospital Corporation | Permanent hair removal using optical pulses |
US5728090A (en) * | 1995-02-09 | 1998-03-17 | Quantum Devices, Inc. | Apparatus for irradiating living cells |
US5885273A (en) * | 1995-03-29 | 1999-03-23 | Esc Medical Systems, Ltd. | Method for depilation using pulsed electromagnetic radiation |
US5624435A (en) * | 1995-06-05 | 1997-04-29 | Cynosure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US5871521A (en) * | 1995-08-25 | 1999-02-16 | Matsushita Electric Industrial Co., Ltd. | Laser probe for medical treatment |
US5879346A (en) * | 1995-12-18 | 1999-03-09 | Esc Medical Systems, Ltd. | Hair removal by selective photothermolysis with an alexandrite laser |
US20020049483A1 (en) * | 1996-01-05 | 2002-04-25 | Knowlton Edward W. | Fluid delivery apparatus |
US6072551A (en) * | 1996-02-14 | 2000-06-06 | Physical Optics Corporation | Backlight apparatus for illuminating a display with controlled light output characteristics |
US5630811A (en) * | 1996-03-25 | 1997-05-20 | Miller; Iain D. | Method and apparatus for hair removal |
US5766214A (en) * | 1996-04-18 | 1998-06-16 | Mehl, Sr.; Thomas L. | Melanin enhanced photothermolysis hair removal |
US5868732A (en) * | 1996-05-12 | 1999-02-09 | Esc Medical Systems, Ltd. | Cooling apparatus for cutaneous treatment employing a laser and method for operating same |
US5743901A (en) * | 1996-05-15 | 1998-04-28 | Star Medical Technologies, Inc. | High fluence diode laser device and method for the fabrication and use thereof |
US6197020B1 (en) * | 1996-08-12 | 2001-03-06 | Sublase, Inc. | Laser apparatus for subsurface cutaneous treatment |
US5871479A (en) * | 1996-11-07 | 1999-02-16 | Cynosure, Inc. | Alexandrite laser system for hair removal and method therefor |
US6379376B1 (en) * | 1996-11-25 | 2002-04-30 | Rachel Lubart | Device for light irradiation onto tissue |
US6188495B1 (en) * | 1996-11-25 | 2001-02-13 | Sony Corporation | Optical transmission-reception apparatus |
US20030032950A1 (en) * | 1996-12-02 | 2003-02-13 | Altshuler Gregory B. | Cooling system for a photo cosmetic device |
US6508813B1 (en) * | 1996-12-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US20030065314A1 (en) * | 1996-12-02 | 2003-04-03 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US6015404A (en) * | 1996-12-02 | 2000-01-18 | Palomar Medical Technologies, Inc. | Laser dermatology with feedback control |
US6208749B1 (en) * | 1997-02-28 | 2001-03-27 | Electro-Optical Sciences, Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
US6511475B1 (en) * | 1997-05-15 | 2003-01-28 | The General Hospital Corporation | Heads for dermatology treatment |
US20050038418A1 (en) * | 1997-05-15 | 2005-02-17 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US20030055414A1 (en) * | 1997-05-15 | 2003-03-20 | Altshuler Gregory B. | Heads for dermatology treatment |
US6517532B1 (en) * | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6251127B1 (en) * | 1997-08-25 | 2001-06-26 | Advanced Photodynamic Technologies, Inc. | Dye treatment solution and photodynamic therapy and method of using same |
US6080146A (en) * | 1998-02-24 | 2000-06-27 | Altshuler; Gregory | Method and apparatus for hair removal |
US6059765A (en) * | 1998-02-26 | 2000-05-09 | Allergan Sales, Inc. | Fluid management system with vertex chamber |
US20040034341A1 (en) * | 1998-03-27 | 2004-02-19 | Palomar Medical Technologies, Inc. | Method and apparatus for the selective targeting of lipid-rich tissues |
US6168831B1 (en) * | 1998-05-22 | 2001-01-02 | Hyundai Electronics America | Apparatus for differential zone lubrication of magnetic recording media and related methods |
US20030094714A1 (en) * | 1998-09-25 | 2003-05-22 | Buazza Omar M. | Plastic lens systems and compositions |
US6228074B1 (en) * | 1998-10-15 | 2001-05-08 | Stephen Almeida | Multiple pulse photo-epilator |
US6887260B1 (en) * | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6183500B1 (en) * | 1998-12-03 | 2001-02-06 | Sli Lichtsysteme Gmbh | Process and apparatus for the cosmetic treatment of acne vulgaris |
US6514242B1 (en) * | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
US6183773B1 (en) * | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US20040006328A1 (en) * | 1999-01-04 | 2004-01-08 | Anderson Richard Rox | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6563853B2 (en) * | 1999-03-12 | 2003-05-13 | Lambda Physik Ag | Gas performance control system for gas discharge lasers |
US6548781B1 (en) * | 1999-04-01 | 2003-04-15 | Microlas Lasersystem Gmbh | Means and method for controlling the intensity distribution of a laser beam |
US6408212B1 (en) * | 1999-04-13 | 2002-06-18 | Joseph Neev | Method for treating acne |
US6533775B1 (en) * | 1999-05-05 | 2003-03-18 | Ioana M. Rizoiu | Light-activated hair treatment and removal device |
US20040122492A1 (en) * | 1999-07-07 | 2004-06-24 | Yoram Harth | Phototherapeutic treatment of skin conditions |
US6516013B1 (en) * | 1999-12-20 | 2003-02-04 | Lambda Physik Ag | Laser beam monitoring apparatus and method |
US20030004499A1 (en) * | 2000-01-13 | 2003-01-02 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
US20020005475A1 (en) * | 2000-04-28 | 2002-01-17 | Zenzie Henry H. | Contact detecting method and apparatus for an optical radiation handpiece |
US6536914B2 (en) * | 2000-05-04 | 2003-03-25 | Koninklijke Philips Electronics N.V. | Illumination system, light mixing chamber and display device |
US20020015430A1 (en) * | 2000-05-15 | 2002-02-07 | Lambda Physik Ag | Electrical excitation circuit for a pulsed gas laser |
US20020031160A1 (en) * | 2000-08-04 | 2002-03-14 | Lambda Physik Ag | Delay compensation for magnetic compressors |
US6567696B2 (en) * | 2001-02-06 | 2003-05-20 | Mediseb Ltd. | Physiotherapeutic device |
US20070027440A1 (en) * | 2001-03-02 | 2007-02-01 | Palomar Medical Technologies, Inc. | Apparatus and method for photocosmetic and photodermatological treatment |
US20030046825A1 (en) * | 2001-04-02 | 2003-03-13 | Slingo Fred M. | Hair dryer employing far infrared radiation and negative ions |
US20030036751A1 (en) * | 2001-05-30 | 2003-02-20 | Anderson R. Rox | Apparatus and method for laser treatment with spectroscopic feedback |
US20030105069A1 (en) * | 2001-05-31 | 2003-06-05 | Robinson Byron C. | Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy |
US6723090B2 (en) * | 2001-07-02 | 2004-04-20 | Palomar Medical Technologies, Inc. | Fiber laser device for medical/cosmetic procedures |
US20030055413A1 (en) * | 2001-07-02 | 2003-03-20 | Altshuler Gregory B. | Fiber laser device for medical/cosmetic procedures |
US20030009158A1 (en) * | 2001-07-09 | 2003-01-09 | Perricone Nicholas V. | Skin treatments using blue and violet light |
US20030050561A1 (en) * | 2001-07-09 | 2003-03-13 | L'oreal | System and method for evaluating a characteristic of body typology |
US20050107849A1 (en) * | 2001-11-29 | 2005-05-19 | Altshuler Gregory B. | Tissue penetrating oral phototherapy applicator |
WO2003049633A1 (en) * | 2001-12-10 | 2003-06-19 | Inolase 2002 Ltd. | Method and apparatus for improving safety during exposure to a monochromatic light source |
US20040036975A1 (en) * | 2001-12-10 | 2004-02-26 | Michael Slatkine | Method and apparatus for improving safety during exposure to a monochromatic light source |
US20040010298A1 (en) * | 2001-12-27 | 2004-01-15 | Gregory Altshuler | Method and apparatus for improved vascular related treatment |
US20040034319A1 (en) * | 2002-03-12 | 2004-02-19 | Palomar Medical Technologies, Inc. | Method and apparatus for hair growth management |
US20040010299A1 (en) * | 2002-04-16 | 2004-01-15 | Seedling Enterprises, Llc | Chemiluminescent light source using visible light for biotherapy |
US20040093042A1 (en) * | 2002-06-19 | 2004-05-13 | Palomar Medical Technologies, Inc. | Method and apparatus for photothermal treatment of tissue at depth |
US20040073079A1 (en) * | 2002-06-19 | 2004-04-15 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
US20040120151A1 (en) * | 2002-12-20 | 2004-06-24 | Cao Group, Inc. | Forensic light using semiconductor light source |
US7452356B2 (en) * | 2003-02-25 | 2008-11-18 | Tria Beauty, Inc. | Eye-safe dermatologic treatment apparatus |
US20050008049A1 (en) * | 2003-06-03 | 2005-01-13 | Hirotaka Oomori | Optical module including a Peltier device therein and having a co-axial type package |
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US10314589B2 (en) | 2006-06-27 | 2019-06-11 | Ethicon Llc | Surgical instrument including a shifting assembly |
US11272938B2 (en) | 2006-06-27 | 2022-03-15 | Cilag Gmbh International | Surgical instrument including dedicated firing and retraction assemblies |
US10420560B2 (en) | 2006-06-27 | 2019-09-24 | Ethicon Llc | Manually driven surgical cutting and fastening instrument |
US11622785B2 (en) | 2006-09-29 | 2023-04-11 | Cilag Gmbh International | Surgical staples having attached drivers and stapling instruments for deploying the same |
US11571231B2 (en) | 2006-09-29 | 2023-02-07 | Cilag Gmbh International | Staple cartridge having a driver for driving multiple staples |
US10448952B2 (en) | 2006-09-29 | 2019-10-22 | Ethicon Llc | End effector for use with a surgical fastening instrument |
US9706991B2 (en) | 2006-09-29 | 2017-07-18 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising staples including a lateral base |
US10568652B2 (en) | 2006-09-29 | 2020-02-25 | Ethicon Llc | Surgical staples having attached drivers of different heights and stapling instruments for deploying the same |
US10172616B2 (en) | 2006-09-29 | 2019-01-08 | Ethicon Llc | Surgical staple cartridge |
US10595862B2 (en) | 2006-09-29 | 2020-03-24 | Ethicon Llc | Staple cartridge including a compressible member |
US10206678B2 (en) | 2006-10-03 | 2019-02-19 | Ethicon Llc | Surgical stapling instrument with lockout features to prevent advancement of a firing assembly unless an unfired surgical staple cartridge is operably mounted in an end effector portion of the instrument |
US11877748B2 (en) | 2006-10-03 | 2024-01-23 | Cilag Gmbh International | Robotically-driven surgical instrument with E-beam driver |
US11382626B2 (en) | 2006-10-03 | 2022-07-12 | Cilag Gmbh International | Surgical system including a knife bar supported for rotational and axial travel |
US10342541B2 (en) | 2006-10-03 | 2019-07-09 | Ethicon Llc | Surgical instruments with E-beam driver and rotary drive arrangements |
US11918211B2 (en) | 2007-01-10 | 2024-03-05 | Cilag Gmbh International | Surgical stapling instrument for use with a robotic system |
US11937814B2 (en) | 2007-01-10 | 2024-03-26 | Cilag Gmbh International | Surgical instrument for use with a robotic system |
US10278780B2 (en) | 2007-01-10 | 2019-05-07 | Ethicon Llc | Surgical instrument for use with robotic system |
US11000277B2 (en) | 2007-01-10 | 2021-05-11 | Ethicon Llc | Surgical instrument with wireless communication between control unit and remote sensor |
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US11291441B2 (en) | 2007-01-10 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with wireless communication between control unit and remote sensor |
US11666332B2 (en) | 2007-01-10 | 2023-06-06 | Cilag Gmbh International | Surgical instrument comprising a control circuit configured to adjust the operation of a motor |
US10517590B2 (en) | 2007-01-10 | 2019-12-31 | Ethicon Llc | Powered surgical instrument having a transmission system |
US10517682B2 (en) | 2007-01-10 | 2019-12-31 | Ethicon Llc | Surgical instrument with wireless communication between control unit and remote sensor |
US11771426B2 (en) | 2007-01-10 | 2023-10-03 | Cilag Gmbh International | Surgical instrument with wireless communication |
US11812961B2 (en) | 2007-01-10 | 2023-11-14 | Cilag Gmbh International | Surgical instrument including a motor control system |
US10945729B2 (en) | 2007-01-10 | 2021-03-16 | Ethicon Llc | Interlock and surgical instrument including same |
US10918386B2 (en) | 2007-01-10 | 2021-02-16 | Ethicon Llc | Interlock and surgical instrument including same |
US10441369B2 (en) | 2007-01-10 | 2019-10-15 | Ethicon Llc | Articulatable surgical instrument configured for detachable use with a robotic system |
US10433918B2 (en) | 2007-01-10 | 2019-10-08 | Ethicon Llc | Surgical instrument system configured to evaluate the load applied to a firing member at the initiation of a firing stroke |
US11064998B2 (en) | 2007-01-10 | 2021-07-20 | Cilag Gmbh International | Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor |
US11166720B2 (en) | 2007-01-10 | 2021-11-09 | Cilag Gmbh International | Surgical instrument including a control module for assessing an end effector |
US11006951B2 (en) | 2007-01-10 | 2021-05-18 | Ethicon Llc | Surgical instrument with wireless communication between control unit and sensor transponders |
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US11134943B2 (en) | 2007-01-10 | 2021-10-05 | Cilag Gmbh International | Powered surgical instrument including a control unit and sensor |
US11931032B2 (en) | 2007-01-10 | 2024-03-19 | Cilag Gmbh International | Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor |
US11849947B2 (en) | 2007-01-10 | 2023-12-26 | Cilag Gmbh International | Surgical system including a control circuit and a passively-powered transponder |
US11844521B2 (en) | 2007-01-10 | 2023-12-19 | Cilag Gmbh International | Surgical instrument for use with a robotic system |
US11350929B2 (en) | 2007-01-10 | 2022-06-07 | Cilag Gmbh International | Surgical instrument with wireless communication between control unit and sensor transponders |
US11839352B2 (en) | 2007-01-11 | 2023-12-12 | Cilag Gmbh International | Surgical stapling device with an end effector |
US10912575B2 (en) | 2007-01-11 | 2021-02-09 | Ethicon Llc | Surgical stapling device having supports for a flexible drive mechanism |
US9750501B2 (en) | 2007-01-11 | 2017-09-05 | Ethicon Endo-Surgery, Llc | Surgical stapling devices having laterally movable anvils |
US11039836B2 (en) | 2007-01-11 | 2021-06-22 | Cilag Gmbh International | Staple cartridge for use with a surgical stapling instrument |
US10702267B2 (en) | 2007-03-15 | 2020-07-07 | Ethicon Llc | Surgical stapling instrument having a releasable buttress material |
US11337693B2 (en) | 2007-03-15 | 2022-05-24 | Cilag Gmbh International | Surgical stapling instrument having a releasable buttress material |
US9872682B2 (en) | 2007-03-15 | 2018-01-23 | Ethicon Llc | Surgical stapling instrument having a releasable buttress material |
US10398433B2 (en) | 2007-03-28 | 2019-09-03 | Ethicon Llc | Laparoscopic clamp load measuring devices |
US20080262484A1 (en) * | 2007-04-23 | 2008-10-23 | Nlight Photonics Corporation | Motion-controlled laser surface treatment apparatus |
US10299787B2 (en) | 2007-06-04 | 2019-05-28 | Ethicon Llc | Stapling system comprising rotary inputs |
US11648006B2 (en) | 2007-06-04 | 2023-05-16 | Cilag Gmbh International | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US11559302B2 (en) | 2007-06-04 | 2023-01-24 | Cilag Gmbh International | Surgical instrument including a firing member movable at different speeds |
US11134938B2 (en) | 2007-06-04 | 2021-10-05 | Cilag Gmbh International | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US11911028B2 (en) | 2007-06-04 | 2024-02-27 | Cilag Gmbh International | Surgical instruments for use with a robotic surgical system |
US11564682B2 (en) | 2007-06-04 | 2023-01-31 | Cilag Gmbh International | Surgical stapler device |
US11147549B2 (en) | 2007-06-04 | 2021-10-19 | Cilag Gmbh International | Stapling instrument including a firing system and a closure system |
US10441280B2 (en) | 2007-06-04 | 2019-10-15 | Ethicon Llc | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US9987003B2 (en) | 2007-06-04 | 2018-06-05 | Ethicon Llc | Robotic actuator assembly |
US10368863B2 (en) | 2007-06-04 | 2019-08-06 | Ethicon Llc | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US10363033B2 (en) | 2007-06-04 | 2019-07-30 | Ethicon Llc | Robotically-controlled surgical instruments |
US9795381B2 (en) | 2007-06-04 | 2017-10-24 | Ethicon Endo-Surgery, Llc | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US11672531B2 (en) | 2007-06-04 | 2023-06-13 | Cilag Gmbh International | Rotary drive systems for surgical instruments |
US10327765B2 (en) | 2007-06-04 | 2019-06-25 | Ethicon Llc | Drive systems for surgical instruments |
US11154298B2 (en) | 2007-06-04 | 2021-10-26 | Cilag Gmbh International | Stapling system for use with a robotic surgical system |
US11857181B2 (en) | 2007-06-04 | 2024-01-02 | Cilag Gmbh International | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US11013511B2 (en) | 2007-06-22 | 2021-05-25 | Ethicon Llc | Surgical stapling instrument with an articulatable end effector |
US11925346B2 (en) | 2007-06-29 | 2024-03-12 | Cilag Gmbh International | Surgical staple cartridge including tissue supporting surfaces |
US11849941B2 (en) | 2007-06-29 | 2023-12-26 | Cilag Gmbh International | Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis |
US11638583B2 (en) | 2008-02-14 | 2023-05-02 | Cilag Gmbh International | Motorized surgical system having a plurality of power sources |
US10206676B2 (en) | 2008-02-14 | 2019-02-19 | Ethicon Llc | Surgical cutting and fastening instrument |
US10682141B2 (en) | 2008-02-14 | 2020-06-16 | Ethicon Llc | Surgical device including a control system |
US10806450B2 (en) | 2008-02-14 | 2020-10-20 | Ethicon Llc | Surgical cutting and fastening instrument having a control system |
US10238385B2 (en) | 2008-02-14 | 2019-03-26 | Ethicon Llc | Surgical instrument system for evaluating tissue impedance |
US10238387B2 (en) | 2008-02-14 | 2019-03-26 | Ethicon Llc | Surgical instrument comprising a control system |
US11484307B2 (en) | 2008-02-14 | 2022-11-01 | Cilag Gmbh International | Loading unit coupleable to a surgical stapling system |
US9867618B2 (en) | 2008-02-14 | 2018-01-16 | Ethicon Llc | Surgical stapling apparatus including firing force regulation |
US9962158B2 (en) | 2008-02-14 | 2018-05-08 | Ethicon Llc | Surgical stapling apparatuses with lockable end effector positioning systems |
US10682142B2 (en) | 2008-02-14 | 2020-06-16 | Ethicon Llc | Surgical stapling apparatus including an articulation system |
US9872684B2 (en) | 2008-02-14 | 2018-01-23 | Ethicon Llc | Surgical stapling apparatus including firing force regulation |
US9877723B2 (en) | 2008-02-14 | 2018-01-30 | Ethicon Llc | Surgical stapling assembly comprising a selector arrangement |
US11801047B2 (en) | 2008-02-14 | 2023-10-31 | Cilag Gmbh International | Surgical stapling system comprising a control circuit configured to selectively monitor tissue impedance and adjust control of a motor |
US10660640B2 (en) | 2008-02-14 | 2020-05-26 | Ethicon Llc | Motorized surgical cutting and fastening instrument |
US11464514B2 (en) | 2008-02-14 | 2022-10-11 | Cilag Gmbh International | Motorized surgical stapling system including a sensing array |
US11446034B2 (en) | 2008-02-14 | 2022-09-20 | Cilag Gmbh International | Surgical stapling assembly comprising first and second actuation systems configured to perform different functions |
US10779822B2 (en) | 2008-02-14 | 2020-09-22 | Ethicon Llc | System including a surgical cutting and fastening instrument |
US10639036B2 (en) | 2008-02-14 | 2020-05-05 | Ethicon Llc | Robotically-controlled motorized surgical cutting and fastening instrument |
US10743870B2 (en) | 2008-02-14 | 2020-08-18 | Ethicon Llc | Surgical stapling apparatus with interlockable firing system |
US10463370B2 (en) | 2008-02-14 | 2019-11-05 | Ethicon Llc | Motorized surgical instrument |
US10265067B2 (en) | 2008-02-14 | 2019-04-23 | Ethicon Llc | Surgical instrument including a regulator and a control system |
US9901346B2 (en) | 2008-02-14 | 2018-02-27 | Ethicon Llc | Stapling assembly |
US10716568B2 (en) | 2008-02-14 | 2020-07-21 | Ethicon Llc | Surgical stapling apparatus with control features operable with one hand |
US10874396B2 (en) | 2008-02-14 | 2020-12-29 | Ethicon Llc | Stapling instrument for use with a surgical robot |
US10888329B2 (en) | 2008-02-14 | 2021-01-12 | Ethicon Llc | Detachable motor powered surgical instrument |
US11612395B2 (en) | 2008-02-14 | 2023-03-28 | Cilag Gmbh International | Surgical system including a control system having an RFID tag reader |
US10888330B2 (en) | 2008-02-14 | 2021-01-12 | Ethicon Llc | Surgical system |
US10765432B2 (en) | 2008-02-14 | 2020-09-08 | Ethicon Llc | Surgical device including a control system |
US10898194B2 (en) | 2008-02-14 | 2021-01-26 | Ethicon Llc | Detachable motor powered surgical instrument |
US9980729B2 (en) | 2008-02-14 | 2018-05-29 | Ethicon Endo-Surgery, Llc | Detachable motor powered surgical instrument |
US9901345B2 (en) | 2008-02-14 | 2018-02-27 | Ethicon Llc | Stapling assembly |
US10898195B2 (en) | 2008-02-14 | 2021-01-26 | Ethicon Llc | Detachable motor powered surgical instrument |
US11717285B2 (en) | 2008-02-14 | 2023-08-08 | Cilag Gmbh International | Surgical cutting and fastening instrument having RF electrodes |
US9901344B2 (en) | 2008-02-14 | 2018-02-27 | Ethicon Llc | Stapling assembly |
US10743851B2 (en) | 2008-02-14 | 2020-08-18 | Ethicon Llc | Interchangeable tools for surgical instruments |
US10722232B2 (en) | 2008-02-14 | 2020-07-28 | Ethicon Llc | Surgical instrument for use with different cartridges |
US10542974B2 (en) | 2008-02-14 | 2020-01-28 | Ethicon Llc | Surgical instrument including a control system |
US10905427B2 (en) | 2008-02-14 | 2021-02-02 | Ethicon Llc | Surgical System |
US10905426B2 (en) | 2008-02-14 | 2021-02-02 | Ethicon Llc | Detachable motor powered surgical instrument |
US10004505B2 (en) | 2008-02-14 | 2018-06-26 | Ethicon Llc | Detachable motor powered surgical instrument |
US10925605B2 (en) | 2008-02-14 | 2021-02-23 | Ethicon Llc | Surgical stapling system |
US9999426B2 (en) | 2008-02-14 | 2018-06-19 | Ethicon Llc | Detachable motor powered surgical instrument |
US10470763B2 (en) | 2008-02-14 | 2019-11-12 | Ethicon Llc | Surgical cutting and fastening instrument including a sensing system |
US10307163B2 (en) | 2008-02-14 | 2019-06-04 | Ethicon Llc | Detachable motor powered surgical instrument |
US11571212B2 (en) | 2008-02-14 | 2023-02-07 | Cilag Gmbh International | Surgical stapling system including an impedance sensor |
US11154297B2 (en) | 2008-02-15 | 2021-10-26 | Cilag Gmbh International | Layer arrangements for surgical staple cartridges |
US10856866B2 (en) | 2008-02-15 | 2020-12-08 | Ethicon Llc | Surgical end effector having buttress retention features |
US11272927B2 (en) | 2008-02-15 | 2022-03-15 | Cilag Gmbh International | Layer arrangements for surgical staple cartridges |
US11058418B2 (en) | 2008-02-15 | 2021-07-13 | Cilag Gmbh International | Surgical end effector having buttress retention features |
US10390823B2 (en) | 2008-02-15 | 2019-08-27 | Ethicon Llc | End effector comprising an adjunct |
US10898184B2 (en) | 2008-09-23 | 2021-01-26 | Ethicon Llc | Motor-driven surgical cutting instrument |
US11517304B2 (en) | 2008-09-23 | 2022-12-06 | Cilag Gmbh International | Motor-driven surgical cutting instrument |
US10420549B2 (en) | 2008-09-23 | 2019-09-24 | Ethicon Llc | Motorized surgical instrument |
US10736628B2 (en) | 2008-09-23 | 2020-08-11 | Ethicon Llc | Motor-driven surgical cutting instrument |
US10485537B2 (en) | 2008-09-23 | 2019-11-26 | Ethicon Llc | Motorized surgical instrument |
US10980535B2 (en) | 2008-09-23 | 2021-04-20 | Ethicon Llc | Motorized surgical instrument with an end effector |
US11103241B2 (en) | 2008-09-23 | 2021-08-31 | Cilag Gmbh International | Motor-driven surgical cutting instrument |
US10765425B2 (en) | 2008-09-23 | 2020-09-08 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US10130361B2 (en) | 2008-09-23 | 2018-11-20 | Ethicon Llc | Robotically-controller motorized surgical tool with an end effector |
US10238389B2 (en) | 2008-09-23 | 2019-03-26 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US11617576B2 (en) | 2008-09-23 | 2023-04-04 | Cilag Gmbh International | Motor-driven surgical cutting instrument |
US11812954B2 (en) | 2008-09-23 | 2023-11-14 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
US10045778B2 (en) | 2008-09-23 | 2018-08-14 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US11684361B2 (en) | 2008-09-23 | 2023-06-27 | Cilag Gmbh International | Motor-driven surgical cutting instrument |
US11617575B2 (en) | 2008-09-23 | 2023-04-04 | Cilag Gmbh International | Motor-driven surgical cutting instrument |
US11406380B2 (en) | 2008-09-23 | 2022-08-09 | Cilag Gmbh International | Motorized surgical instrument |
US11648005B2 (en) | 2008-09-23 | 2023-05-16 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
US11045189B2 (en) | 2008-09-23 | 2021-06-29 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
US10105136B2 (en) | 2008-09-23 | 2018-10-23 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US11871923B2 (en) | 2008-09-23 | 2024-01-16 | Cilag Gmbh International | Motorized surgical instrument |
US10456133B2 (en) | 2008-09-23 | 2019-10-29 | Ethicon Llc | Motorized surgical instrument |
US11583279B2 (en) | 2008-10-10 | 2023-02-21 | Cilag Gmbh International | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US10149683B2 (en) | 2008-10-10 | 2018-12-11 | Ethicon Llc | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US11793521B2 (en) | 2008-10-10 | 2023-10-24 | Cilag Gmbh International | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US10932778B2 (en) | 2008-10-10 | 2021-03-02 | Ethicon Llc | Powered surgical cutting and stapling apparatus with manually retractable firing system |
US11730477B2 (en) | 2008-10-10 | 2023-08-22 | Cilag Gmbh International | Powered surgical system with manually retractable firing system |
US11129615B2 (en) | 2009-02-05 | 2021-09-28 | Cilag Gmbh International | Surgical stapling system |
US10758233B2 (en) | 2009-02-05 | 2020-09-01 | Ethicon Llc | Articulatable surgical instrument comprising a firing drive |
US10420550B2 (en) | 2009-02-06 | 2019-09-24 | Ethicon Llc | Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated |
US20100241196A1 (en) * | 2009-03-19 | 2010-09-23 | Tyco Healthcare Group Lp | Phototherapy wound treatment |
US8399731B2 (en) * | 2009-03-19 | 2013-03-19 | Covidien Lp | Phototherapy wound treatment |
US20110037844A1 (en) * | 2009-08-17 | 2011-02-17 | Scot Johnson | Energy emitting device |
WO2011028932A1 (en) * | 2009-09-03 | 2011-03-10 | Lawrence Livermore National Security, Llc | Method and system for powering and cooling semiconductor lasers |
US8660156B2 (en) | 2009-09-03 | 2014-02-25 | Lawrence Livermore National Security, Llc | Method and system for powering and cooling semiconductor lasers |
US20110051759A1 (en) * | 2009-09-03 | 2011-03-03 | Lawrence Livermore National Security, Llc | Method and system for powering and cooling semiconductor layers |
US11291449B2 (en) | 2009-12-24 | 2022-04-05 | Cilag Gmbh International | Surgical cutting instrument that analyzes tissue thickness |
US10751076B2 (en) | 2009-12-24 | 2020-08-25 | Ethicon Llc | Motor-driven surgical cutting instrument with electric actuator directional control assembly |
US11478247B2 (en) | 2010-07-30 | 2022-10-25 | Cilag Gmbh International | Tissue acquisition arrangements and methods for surgical stapling devices |
US20140207211A1 (en) * | 2010-09-03 | 2014-07-24 | Geragem Medisys Inc. | Apparatus for Irradiating Skin Using Light |
US10588623B2 (en) | 2010-09-30 | 2020-03-17 | Ethicon Llc | Adhesive film laminate |
US11559496B2 (en) | 2010-09-30 | 2023-01-24 | Cilag Gmbh International | Tissue thickness compensator configured to redistribute compressive forces |
US11925354B2 (en) | 2010-09-30 | 2024-03-12 | Cilag Gmbh International | Staple cartridge comprising staples positioned within a compressible portion thereof |
US9833238B2 (en) | 2010-09-30 | 2017-12-05 | Ethicon Endo-Surgery, Llc | Retainer assembly including a tissue thickness compensator |
US11850310B2 (en) | 2010-09-30 | 2023-12-26 | Cilag Gmbh International | Staple cartridge including an adjunct |
US9833242B2 (en) | 2010-09-30 | 2017-12-05 | Ethicon Endo-Surgery, Llc | Tissue thickness compensators |
US11849952B2 (en) | 2010-09-30 | 2023-12-26 | Cilag Gmbh International | Staple cartridge comprising staples positioned within a compressible portion thereof |
US10624861B2 (en) | 2010-09-30 | 2020-04-21 | Ethicon Llc | Tissue thickness compensator configured to redistribute compressive forces |
US11154296B2 (en) | 2010-09-30 | 2021-10-26 | Cilag Gmbh International | Anvil layer attached to a proximal end of an end effector |
US10258330B2 (en) | 2010-09-30 | 2019-04-16 | Ethicon Llc | End effector including an implantable arrangement |
US11083452B2 (en) | 2010-09-30 | 2021-08-10 | Cilag Gmbh International | Staple cartridge including a tissue thickness compensator |
US10265072B2 (en) | 2010-09-30 | 2019-04-23 | Ethicon Llc | Surgical stapling system comprising an end effector including an implantable layer |
US10398436B2 (en) | 2010-09-30 | 2019-09-03 | Ethicon Llc | Staple cartridge comprising staples positioned within a compressible portion thereof |
US9826978B2 (en) | 2010-09-30 | 2017-11-28 | Ethicon Llc | End effectors with same side closure and firing motions |
US10136890B2 (en) | 2010-09-30 | 2018-11-27 | Ethicon Llc | Staple cartridge comprising a variable thickness compressible portion |
US11857187B2 (en) | 2010-09-30 | 2024-01-02 | Cilag Gmbh International | Tissue thickness compensator comprising controlled release and expansion |
US9801634B2 (en) | 2010-09-30 | 2017-10-31 | Ethicon Llc | Tissue thickness compensator for a surgical stapler |
US11602340B2 (en) | 2010-09-30 | 2023-03-14 | Cilag Gmbh International | Adhesive film laminate |
US10265074B2 (en) | 2010-09-30 | 2019-04-23 | Ethicon Llc | Implantable layers for surgical stapling devices |
US9795383B2 (en) | 2010-09-30 | 2017-10-24 | Ethicon Llc | Tissue thickness compensator comprising resilient members |
US9629814B2 (en) | 2010-09-30 | 2017-04-25 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator configured to redistribute compressive forces |
US11672536B2 (en) | 2010-09-30 | 2023-06-13 | Cilag Gmbh International | Layer of material for a surgical end effector |
US9924947B2 (en) | 2010-09-30 | 2018-03-27 | Ethicon Llc | Staple cartridge comprising a compressible portion |
US10987102B2 (en) | 2010-09-30 | 2021-04-27 | Ethicon Llc | Tissue thickness compensator comprising a plurality of layers |
US11812965B2 (en) | 2010-09-30 | 2023-11-14 | Cilag Gmbh International | Layer of material for a surgical end effector |
US10463372B2 (en) | 2010-09-30 | 2019-11-05 | Ethicon Llc | Staple cartridge comprising multiple regions |
US11883025B2 (en) | 2010-09-30 | 2024-01-30 | Cilag Gmbh International | Tissue thickness compensator comprising a plurality of layers |
US11684360B2 (en) | 2010-09-30 | 2023-06-27 | Cilag Gmbh International | Staple cartridge comprising a variable thickness compressible portion |
US11298125B2 (en) | 2010-09-30 | 2022-04-12 | Cilag Gmbh International | Tissue stapler having a thickness compensator |
US10363031B2 (en) | 2010-09-30 | 2019-07-30 | Ethicon Llc | Tissue thickness compensators for surgical staplers |
US11583277B2 (en) | 2010-09-30 | 2023-02-21 | Cilag Gmbh International | Layer of material for a surgical end effector |
US10194910B2 (en) | 2010-09-30 | 2019-02-05 | Ethicon Llc | Stapling assemblies comprising a layer |
US11571215B2 (en) | 2010-09-30 | 2023-02-07 | Cilag Gmbh International | Layer of material for a surgical end effector |
US10182819B2 (en) | 2010-09-30 | 2019-01-22 | Ethicon Llc | Implantable layer assemblies |
US10945731B2 (en) | 2010-09-30 | 2021-03-16 | Ethicon Llc | Tissue thickness compensator comprising controlled release and expansion |
US10335148B2 (en) | 2010-09-30 | 2019-07-02 | Ethicon Llc | Staple cartridge including a tissue thickness compensator for a surgical stapler |
US10743877B2 (en) | 2010-09-30 | 2020-08-18 | Ethicon Llc | Surgical stapler with floating anvil |
US10335150B2 (en) | 2010-09-30 | 2019-07-02 | Ethicon Llc | Staple cartridge comprising an implantable layer |
US9814462B2 (en) | 2010-09-30 | 2017-11-14 | Ethicon Llc | Assembly for fastening tissue comprising a compressible layer |
US10485536B2 (en) | 2010-09-30 | 2019-11-26 | Ethicon Llc | Tissue stapler having an anti-microbial agent |
US10028743B2 (en) | 2010-09-30 | 2018-07-24 | Ethicon Llc | Staple cartridge assembly comprising an implantable layer |
US10258332B2 (en) | 2010-09-30 | 2019-04-16 | Ethicon Llc | Stapling system comprising an adjunct and a flowable adhesive |
US10898193B2 (en) | 2010-09-30 | 2021-01-26 | Ethicon Llc | End effector for use with a surgical instrument |
US11911027B2 (en) | 2010-09-30 | 2024-02-27 | Cilag Gmbh International | Adhesive film laminate |
US10149682B2 (en) | 2010-09-30 | 2018-12-11 | Ethicon Llc | Stapling system including an actuation system |
US11944292B2 (en) | 2010-09-30 | 2024-04-02 | Cilag Gmbh International | Anvil layer attached to a proximal end of an end effector |
US10888328B2 (en) | 2010-09-30 | 2021-01-12 | Ethicon Llc | Surgical end effector |
US10064624B2 (en) | 2010-09-30 | 2018-09-04 | Ethicon Llc | End effector with implantable layer |
US11540824B2 (en) | 2010-09-30 | 2023-01-03 | Cilag Gmbh International | Tissue thickness compensator |
US11395651B2 (en) | 2010-09-30 | 2022-07-26 | Cilag Gmbh International | Adhesive film laminate |
US10548600B2 (en) | 2010-09-30 | 2020-02-04 | Ethicon Llc | Multiple thickness implantable layers for surgical stapling devices |
US10869669B2 (en) | 2010-09-30 | 2020-12-22 | Ethicon Llc | Surgical instrument assembly |
US11737754B2 (en) | 2010-09-30 | 2023-08-29 | Cilag Gmbh International | Surgical stapler with floating anvil |
US10835251B2 (en) | 2010-09-30 | 2020-11-17 | Ethicon Llc | Surgical instrument assembly including an end effector configurable in different positions |
US11406377B2 (en) | 2010-09-30 | 2022-08-09 | Cilag Gmbh International | Adhesive film laminate |
US10695062B2 (en) | 2010-10-01 | 2020-06-30 | Ethicon Llc | Surgical instrument including a retractable firing member |
US11529142B2 (en) | 2010-10-01 | 2022-12-20 | Cilag Gmbh International | Surgical instrument having a power control circuit |
US20120245571A1 (en) * | 2011-03-25 | 2012-09-27 | Mordaunt David H | Medical Laser with Electronic Shutter |
US9610124B2 (en) * | 2011-03-25 | 2017-04-04 | Precision Medical Optics, Llc | Medical laser with electronic shutter |
US10117652B2 (en) | 2011-04-29 | 2018-11-06 | Ethicon Llc | End effector comprising a tissue thickness compensator and progressively released attachment members |
US11504116B2 (en) | 2011-04-29 | 2022-11-22 | Cilag Gmbh International | Layer of material for a surgical end effector |
US11918208B2 (en) | 2011-05-27 | 2024-03-05 | Cilag Gmbh International | Robotically-controlled shaft based rotary drive systems for surgical instruments |
US10004506B2 (en) | 2011-05-27 | 2018-06-26 | Ethicon Llc | Surgical system |
US10071452B2 (en) | 2011-05-27 | 2018-09-11 | Ethicon Llc | Automated end effector component reloading system for use with a robotic system |
US10426478B2 (en) | 2011-05-27 | 2019-10-01 | Ethicon Llc | Surgical stapling systems |
US11129616B2 (en) | 2011-05-27 | 2021-09-28 | Cilag Gmbh International | Surgical stapling system |
US10617420B2 (en) | 2011-05-27 | 2020-04-14 | Ethicon Llc | Surgical system comprising drive systems |
US10780539B2 (en) | 2011-05-27 | 2020-09-22 | Ethicon Llc | Stapling instrument for use with a robotic system |
US10130366B2 (en) | 2011-05-27 | 2018-11-20 | Ethicon Llc | Automated reloading devices for replacing used end effectors on robotic surgical systems |
US9775614B2 (en) | 2011-05-27 | 2017-10-03 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments with rotatable staple deployment arrangements |
US10231794B2 (en) | 2011-05-27 | 2019-03-19 | Ethicon Llc | Surgical stapling instruments with rotatable staple deployment arrangements |
US9913648B2 (en) | 2011-05-27 | 2018-03-13 | Ethicon Endo-Surgery, Llc | Surgical system |
US10813641B2 (en) | 2011-05-27 | 2020-10-27 | Ethicon Llc | Robotically-driven surgical instrument |
US10485546B2 (en) | 2011-05-27 | 2019-11-26 | Ethicon Llc | Robotically-driven surgical assembly |
US11266410B2 (en) | 2011-05-27 | 2022-03-08 | Cilag Gmbh International | Surgical device for use with a robotic system |
US11207064B2 (en) | 2011-05-27 | 2021-12-28 | Cilag Gmbh International | Automated end effector component reloading system for use with a robotic system |
US10736634B2 (en) | 2011-05-27 | 2020-08-11 | Ethicon Llc | Robotically-driven surgical instrument including a drive system |
US10420561B2 (en) | 2011-05-27 | 2019-09-24 | Ethicon Llc | Robotically-driven surgical instrument |
US10524790B2 (en) | 2011-05-27 | 2020-01-07 | Ethicon Llc | Robotically-controlled surgical stapling devices that produce formed staples having different lengths |
US11612394B2 (en) | 2011-05-27 | 2023-03-28 | Cilag Gmbh International | Automated end effector component reloading system for use with a robotic system |
US10335151B2 (en) | 2011-05-27 | 2019-07-02 | Ethicon Llc | Robotically-driven surgical instrument |
US11439470B2 (en) | 2011-05-27 | 2022-09-13 | Cilag Gmbh International | Robotically-controlled surgical instrument with selectively articulatable end effector |
US10980534B2 (en) | 2011-05-27 | 2021-04-20 | Ethicon Llc | Robotically-controlled motorized surgical instrument with an end effector |
US11583278B2 (en) | 2011-05-27 | 2023-02-21 | Cilag Gmbh International | Surgical stapling system having multi-direction articulation |
US10383633B2 (en) | 2011-05-27 | 2019-08-20 | Ethicon Llc | Robotically-driven surgical assembly |
US9687237B2 (en) | 2011-09-23 | 2017-06-27 | Ethicon Endo-Surgery, Llc | Staple cartridge including collapsible deck arrangement |
US10695063B2 (en) | 2012-02-13 | 2020-06-30 | Ethicon Llc | Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status |
US9730697B2 (en) | 2012-02-13 | 2017-08-15 | Ethicon Endo-Surgery, Llc | Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status |
US8961578B2 (en) | 2012-03-21 | 2015-02-24 | Tria Beauty, Inc. | Dermatological treatment device with one or more vertical cavity surface emitting lasers (VCSEL) |
US11918220B2 (en) | 2012-03-28 | 2024-03-05 | Cilag Gmbh International | Tissue thickness compensator comprising tissue ingrowth features |
US9918716B2 (en) | 2012-03-28 | 2018-03-20 | Ethicon Llc | Staple cartridge comprising implantable layers |
US9724098B2 (en) | 2012-03-28 | 2017-08-08 | Ethicon Endo-Surgery, Llc | Staple cartridge comprising an implantable layer |
US10441285B2 (en) | 2012-03-28 | 2019-10-15 | Ethicon Llc | Tissue thickness compensator comprising tissue ingrowth features |
US9974538B2 (en) | 2012-03-28 | 2018-05-22 | Ethicon Llc | Staple cartridge comprising a compressible layer |
US10667808B2 (en) | 2012-03-28 | 2020-06-02 | Ethicon Llc | Staple cartridge comprising an absorbable adjunct |
US11793509B2 (en) | 2012-03-28 | 2023-10-24 | Cilag Gmbh International | Staple cartridge including an implantable layer |
US11406378B2 (en) | 2012-03-28 | 2022-08-09 | Cilag Gmbh International | Staple cartridge comprising a compressible tissue thickness compensator |
US20150051593A1 (en) * | 2012-04-02 | 2015-02-19 | Koninklijke Philips N.V. | Light based skin treatment device avoiding liob in air |
US10813694B2 (en) * | 2012-04-02 | 2020-10-27 | Koninklijke Philips N.V. | Light based skin treatment device avoiding LIOB in air |
US10959725B2 (en) | 2012-06-15 | 2021-03-30 | Ethicon Llc | Articulatable surgical instrument comprising a firing drive |
US11707273B2 (en) | 2012-06-15 | 2023-07-25 | Cilag Gmbh International | Articulatable surgical instrument comprising a firing drive |
US10064621B2 (en) | 2012-06-15 | 2018-09-04 | Ethicon Llc | Articulatable surgical instrument comprising a firing drive |
US10687812B2 (en) | 2012-06-28 | 2020-06-23 | Ethicon Llc | Surgical instrument system including replaceable end effectors |
US9907620B2 (en) | 2012-06-28 | 2018-03-06 | Ethicon Endo-Surgery, Llc | Surgical end effectors having angled tissue-contacting surfaces |
US11622766B2 (en) | 2012-06-28 | 2023-04-11 | Cilag Gmbh International | Empty clip cartridge lockout |
US10258333B2 (en) | 2012-06-28 | 2019-04-16 | Ethicon Llc | Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system |
US10420555B2 (en) | 2012-06-28 | 2019-09-24 | Ethicon Llc | Hand held rotary powered surgical instruments with end effectors that are articulatable about multiple axes |
US11109860B2 (en) | 2012-06-28 | 2021-09-07 | Cilag Gmbh International | Surgical end effectors for use with hand-held and robotically-controlled rotary powered surgical systems |
US10413294B2 (en) | 2012-06-28 | 2019-09-17 | Ethicon Llc | Shaft assembly arrangements for surgical instruments |
US11154299B2 (en) | 2012-06-28 | 2021-10-26 | Cilag Gmbh International | Stapling assembly comprising a firing lockout |
US11083457B2 (en) | 2012-06-28 | 2021-08-10 | Cilag Gmbh International | Surgical instrument system including replaceable end effectors |
US11197671B2 (en) | 2012-06-28 | 2021-12-14 | Cilag Gmbh International | Stapling assembly comprising a lockout |
US11058423B2 (en) | 2012-06-28 | 2021-07-13 | Cilag Gmbh International | Stapling system including first and second closure systems for use with a surgical robot |
US11202631B2 (en) | 2012-06-28 | 2021-12-21 | Cilag Gmbh International | Stapling assembly comprising a firing lockout |
US11141155B2 (en) | 2012-06-28 | 2021-10-12 | Cilag Gmbh International | Drive system for surgical tool |
US11510671B2 (en) | 2012-06-28 | 2022-11-29 | Cilag Gmbh International | Firing system lockout arrangements for surgical instruments |
US11141156B2 (en) | 2012-06-28 | 2021-10-12 | Cilag Gmbh International | Surgical stapling assembly comprising flexible output shaft |
US11464513B2 (en) | 2012-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument system including replaceable end effectors |
US11241230B2 (en) | 2012-06-28 | 2022-02-08 | Cilag Gmbh International | Clip applier tool for use with a robotic surgical system |
US11039837B2 (en) | 2012-06-28 | 2021-06-22 | Cilag Gmbh International | Firing system lockout arrangements for surgical instruments |
US11602346B2 (en) | 2012-06-28 | 2023-03-14 | Cilag Gmbh International | Robotically powered surgical device with manually-actuatable reversing system |
US10639115B2 (en) | 2012-06-28 | 2020-05-05 | Ethicon Llc | Surgical end effectors having angled tissue-contacting surfaces |
US11779420B2 (en) | 2012-06-28 | 2023-10-10 | Cilag Gmbh International | Robotic surgical attachments having manually-actuated retraction assemblies |
US11007004B2 (en) | 2012-06-28 | 2021-05-18 | Ethicon Llc | Powered multi-axial articulable electrosurgical device with external dissection features |
US11918213B2 (en) | 2012-06-28 | 2024-03-05 | Cilag Gmbh International | Surgical stapler including couplers for attaching a shaft to an end effector |
US10874391B2 (en) | 2012-06-28 | 2020-12-29 | Ethicon Llc | Surgical instrument system including replaceable end effectors |
US10485541B2 (en) | 2012-06-28 | 2019-11-26 | Ethicon Llc | Robotically powered surgical device with manually-actuatable reversing system |
US11857189B2 (en) | 2012-06-28 | 2024-01-02 | Cilag Gmbh International | Surgical instrument including first and second articulation joints |
US11534162B2 (en) | 2012-06-28 | 2022-12-27 | Cilag GmbH Inlernational | Robotically powered surgical device with manually-actuatable reversing system |
US10383630B2 (en) | 2012-06-28 | 2019-08-20 | Ethicon Llc | Surgical stapling device with rotary driven firing member |
US11278284B2 (en) | 2012-06-28 | 2022-03-22 | Cilag Gmbh International | Rotary drive arrangements for surgical instruments |
US11540829B2 (en) | 2012-06-28 | 2023-01-03 | Cilag Gmbh International | Surgical instrument system including replaceable end effectors |
US11806013B2 (en) | 2012-06-28 | 2023-11-07 | Cilag Gmbh International | Firing system arrangements for surgical instruments |
US10932775B2 (en) | 2012-06-28 | 2021-03-02 | Ethicon Llc | Firing system lockout arrangements for surgical instruments |
US11373755B2 (en) | 2012-08-23 | 2022-06-28 | Cilag Gmbh International | Surgical device drive system including a ratchet mechanism |
US11135444B2 (en) * | 2012-11-01 | 2021-10-05 | Seminex Corporation | Variable intensity laser treatments of the skin |
WO2014076503A1 (en) * | 2012-11-19 | 2014-05-22 | Sagentia Limited | Handheld device for light treatment of skin |
US9797187B2 (en) * | 2013-01-14 | 2017-10-24 | Carnegie Mellon University, A Pennsylvania Non-Profit Corporation | Devices for modulation of temperature and light based on phase change materials |
US20140196868A1 (en) * | 2013-01-14 | 2014-07-17 | Carnegie Mellon University, Center For Technology Transfer And Enterprise Creation | Devices for Modulation of Temperature and Light Based on Phase Change Materials |
US10575868B2 (en) | 2013-03-01 | 2020-03-03 | Ethicon Llc | Surgical instrument with coupler assembly |
US11529138B2 (en) | 2013-03-01 | 2022-12-20 | Cilag Gmbh International | Powered surgical instrument including a rotary drive screw |
US11246618B2 (en) | 2013-03-01 | 2022-02-15 | Cilag Gmbh International | Surgical instrument soft stop |
US10226249B2 (en) | 2013-03-01 | 2019-03-12 | Ethicon Llc | Articulatable surgical instruments with conductive pathways for signal communication |
US10285695B2 (en) | 2013-03-01 | 2019-05-14 | Ethicon Llc | Articulatable surgical instruments with conductive pathways |
US9883860B2 (en) | 2013-03-14 | 2018-02-06 | Ethicon Llc | Interchangeable shaft assemblies for use with a surgical instrument |
US10893867B2 (en) | 2013-03-14 | 2021-01-19 | Ethicon Llc | Drive train control arrangements for modular surgical instruments |
US11266406B2 (en) | 2013-03-14 | 2022-03-08 | Cilag Gmbh International | Control systems for surgical instruments |
US10470762B2 (en) | 2013-03-14 | 2019-11-12 | Ethicon Llc | Multi-function motor for a surgical instrument |
US10617416B2 (en) | 2013-03-14 | 2020-04-14 | Ethicon Llc | Control systems for surgical instruments |
US10238391B2 (en) | 2013-03-14 | 2019-03-26 | Ethicon Llc | Drive train control arrangements for modular surgical instruments |
US9801626B2 (en) | 2013-04-16 | 2017-10-31 | Ethicon Llc | Modular motor driven surgical instruments with alignment features for aligning rotary drive shafts with surgical end effector shafts |
US11395652B2 (en) | 2013-04-16 | 2022-07-26 | Cilag Gmbh International | Powered surgical stapler |
US9844368B2 (en) | 2013-04-16 | 2017-12-19 | Ethicon Llc | Surgical system comprising first and second drive systems |
US11690615B2 (en) | 2013-04-16 | 2023-07-04 | Cilag Gmbh International | Surgical system including an electric motor and a surgical instrument |
US11406381B2 (en) | 2013-04-16 | 2022-08-09 | Cilag Gmbh International | Powered surgical stapler |
US9814460B2 (en) | 2013-04-16 | 2017-11-14 | Ethicon Llc | Modular motor driven surgical instruments with status indication arrangements |
US10702266B2 (en) | 2013-04-16 | 2020-07-07 | Ethicon Llc | Surgical instrument system |
US11622763B2 (en) | 2013-04-16 | 2023-04-11 | Cilag Gmbh International | Stapling assembly comprising a shiftable drive |
US10149680B2 (en) | 2013-04-16 | 2018-12-11 | Ethicon Llc | Surgical instrument comprising a gap setting system |
US10888318B2 (en) | 2013-04-16 | 2021-01-12 | Ethicon Llc | Powered surgical stapler |
US9867612B2 (en) | 2013-04-16 | 2018-01-16 | Ethicon Llc | Powered surgical stapler |
US11638581B2 (en) | 2013-04-16 | 2023-05-02 | Cilag Gmbh International | Powered surgical stapler |
US11633183B2 (en) | 2013-04-16 | 2023-04-25 | Cilag International GmbH | Stapling assembly comprising a retraction drive |
US11564679B2 (en) | 2013-04-16 | 2023-01-31 | Cilag Gmbh International | Powered surgical stapler |
US10405857B2 (en) | 2013-04-16 | 2019-09-10 | Ethicon Llc | Powered linear surgical stapler |
US10136887B2 (en) | 2013-04-16 | 2018-11-27 | Ethicon Llc | Drive system decoupling arrangement for a surgical instrument |
US9826976B2 (en) | 2013-04-16 | 2017-11-28 | Ethicon Llc | Motor driven surgical instruments with lockable dual drive shafts |
US9649110B2 (en) | 2013-04-16 | 2017-05-16 | Ethicon Llc | Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output |
US10624634B2 (en) | 2013-08-23 | 2020-04-21 | Ethicon Llc | Firing trigger lockout arrangements for surgical instruments |
US11109858B2 (en) | 2013-08-23 | 2021-09-07 | Cilag Gmbh International | Surgical instrument including a display which displays the position of a firing element |
US10898190B2 (en) | 2013-08-23 | 2021-01-26 | Ethicon Llc | Secondary battery arrangements for powered surgical instruments |
US9924942B2 (en) | 2013-08-23 | 2018-03-27 | Ethicon Llc | Motor-powered articulatable surgical instruments |
US11000274B2 (en) | 2013-08-23 | 2021-05-11 | Ethicon Llc | Powered surgical instrument |
US11918209B2 (en) | 2013-08-23 | 2024-03-05 | Cilag Gmbh International | Torque optimization for surgical instruments |
US11026680B2 (en) | 2013-08-23 | 2021-06-08 | Cilag Gmbh International | Surgical instrument configured to operate in different states |
US11701110B2 (en) | 2013-08-23 | 2023-07-18 | Cilag Gmbh International | Surgical instrument including a drive assembly movable in a non-motorized mode of operation |
US11389160B2 (en) | 2013-08-23 | 2022-07-19 | Cilag Gmbh International | Surgical system comprising a display |
US10201349B2 (en) | 2013-08-23 | 2019-02-12 | Ethicon Llc | End effector detection and firing rate modulation systems for surgical instruments |
US11504119B2 (en) | 2013-08-23 | 2022-11-22 | Cilag Gmbh International | Surgical instrument including an electronic firing lockout |
US11376001B2 (en) | 2013-08-23 | 2022-07-05 | Cilag Gmbh International | Surgical stapling device with rotary multi-turn retraction mechanism |
US9700310B2 (en) | 2013-08-23 | 2017-07-11 | Ethicon Llc | Firing member retraction devices for powered surgical instruments |
US10828032B2 (en) | 2013-08-23 | 2020-11-10 | Ethicon Llc | End effector detection systems for surgical instruments |
US11133106B2 (en) | 2013-08-23 | 2021-09-28 | Cilag Gmbh International | Surgical instrument assembly comprising a retraction assembly |
US11134940B2 (en) | 2013-08-23 | 2021-10-05 | Cilag Gmbh International | Surgical instrument including a variable speed firing member |
US10441281B2 (en) | 2013-08-23 | 2019-10-15 | Ethicon Llc | surgical instrument including securing and aligning features |
US10869665B2 (en) | 2013-08-23 | 2020-12-22 | Ethicon Llc | Surgical instrument system including a control system |
US20150126980A1 (en) * | 2013-11-05 | 2015-05-07 | Benzion Levi | Combined galvanic and pulsed optical energy for depilation |
US9827044B2 (en) * | 2013-11-05 | 2017-11-28 | Home Skinovations Ltd. | Combined galvanic and pulsed optical energy for depilation |
US20150153018A1 (en) * | 2013-12-02 | 2015-06-04 | Industrial Technology Research Institute | Beam diffusing module and beam generating system |
US9353929B2 (en) * | 2013-12-02 | 2016-05-31 | Industrial Technology Research Institute | Beam diffusing module and beam generating system |
US11020115B2 (en) | 2014-02-12 | 2021-06-01 | Cilag Gmbh International | Deliverable surgical instrument |
US9962161B2 (en) | 2014-02-12 | 2018-05-08 | Ethicon Llc | Deliverable surgical instrument |
US9757124B2 (en) | 2014-02-24 | 2017-09-12 | Ethicon Llc | Implantable layer assemblies |
US10426481B2 (en) | 2014-02-24 | 2019-10-01 | Ethicon Llc | Implantable layer assemblies |
US9884456B2 (en) | 2014-02-24 | 2018-02-06 | Ethicon Llc | Implantable layers and methods for altering one or more properties of implantable layers for use with fastening instruments |
US9839422B2 (en) | 2014-02-24 | 2017-12-12 | Ethicon Llc | Implantable layers and methods for altering implantable layers for use with surgical fastening instruments |
US9693777B2 (en) | 2014-02-24 | 2017-07-04 | Ethicon Llc | Implantable layers comprising a pressed region |
US9775608B2 (en) | 2014-02-24 | 2017-10-03 | Ethicon Llc | Fastening system comprising a firing member lockout |
US9839423B2 (en) | 2014-02-24 | 2017-12-12 | Ethicon Llc | Implantable layers and methods for modifying the shape of the implantable layers for use with a surgical fastening instrument |
US9690362B2 (en) | 2014-03-26 | 2017-06-27 | Ethicon Llc | Surgical instrument control circuit having a safety processor |
US10863981B2 (en) | 2014-03-26 | 2020-12-15 | Ethicon Llc | Interface systems for use with surgical instruments |
US9913642B2 (en) | 2014-03-26 | 2018-03-13 | Ethicon Llc | Surgical instrument comprising a sensor system |
US9826977B2 (en) | 2014-03-26 | 2017-11-28 | Ethicon Llc | Sterilization verification circuit |
US10201364B2 (en) | 2014-03-26 | 2019-02-12 | Ethicon Llc | Surgical instrument comprising a rotatable shaft |
US10136889B2 (en) | 2014-03-26 | 2018-11-27 | Ethicon Llc | Systems and methods for controlling a segmented circuit |
US9743929B2 (en) | 2014-03-26 | 2017-08-29 | Ethicon Llc | Modular powered surgical instrument with detachable shaft assemblies |
US10898185B2 (en) | 2014-03-26 | 2021-01-26 | Ethicon Llc | Surgical instrument power management through sleep and wake up control |
US10004497B2 (en) | 2014-03-26 | 2018-06-26 | Ethicon Llc | Interface systems for use with surgical instruments |
US10013049B2 (en) | 2014-03-26 | 2018-07-03 | Ethicon Llc | Power management through sleep options of segmented circuit and wake up control |
US11259799B2 (en) | 2014-03-26 | 2022-03-01 | Cilag Gmbh International | Interface systems for use with surgical instruments |
US10028761B2 (en) | 2014-03-26 | 2018-07-24 | Ethicon Llc | Feedback algorithms for manual bailout systems for surgical instruments |
US9750499B2 (en) | 2014-03-26 | 2017-09-05 | Ethicon Llc | Surgical stapling instrument system |
US11497488B2 (en) | 2014-03-26 | 2022-11-15 | Cilag Gmbh International | Systems and methods for controlling a segmented circuit |
US10117653B2 (en) | 2014-03-26 | 2018-11-06 | Ethicon Llc | Systems and methods for controlling a segmented circuit |
US9820738B2 (en) | 2014-03-26 | 2017-11-21 | Ethicon Llc | Surgical instrument comprising interactive systems |
US10588626B2 (en) | 2014-03-26 | 2020-03-17 | Ethicon Llc | Surgical instrument displaying subsequent step of use |
US11298134B2 (en) | 2014-04-16 | 2022-04-12 | Cilag Gmbh International | Fastener cartridge comprising non-uniform fasteners |
US11944307B2 (en) | 2014-04-16 | 2024-04-02 | Cilag Gmbh International | Surgical stapling system including jaw windows |
US11918222B2 (en) | 2014-04-16 | 2024-03-05 | Cilag Gmbh International | Stapling assembly having firing member viewing windows |
US10299792B2 (en) | 2014-04-16 | 2019-05-28 | Ethicon Llc | Fastener cartridge comprising non-uniform fasteners |
US11266409B2 (en) | 2014-04-16 | 2022-03-08 | Cilag Gmbh International | Fastener cartridge comprising a sled including longitudinally-staggered ramps |
US11925353B2 (en) | 2014-04-16 | 2024-03-12 | Cilag Gmbh International | Surgical stapling instrument comprising internal passage between stapling cartridge and elongate channel |
US11185330B2 (en) | 2014-04-16 | 2021-11-30 | Cilag Gmbh International | Fastener cartridge assemblies and staple retainer cover arrangements |
US10327776B2 (en) | 2014-04-16 | 2019-06-25 | Ethicon Llc | Surgical stapling buttresses and adjunct materials |
US11517315B2 (en) | 2014-04-16 | 2022-12-06 | Cilag Gmbh International | Fastener cartridges including extensions having different configurations |
US11596406B2 (en) | 2014-04-16 | 2023-03-07 | Cilag Gmbh International | Fastener cartridges including extensions having different configurations |
US9877721B2 (en) | 2014-04-16 | 2018-01-30 | Ethicon Llc | Fastener cartridge comprising tissue control features |
US11382627B2 (en) | 2014-04-16 | 2022-07-12 | Cilag Gmbh International | Surgical stapling assembly comprising a firing member including a lateral extension |
US11382625B2 (en) | 2014-04-16 | 2022-07-12 | Cilag Gmbh International | Fastener cartridge comprising non-uniform fasteners |
US11717294B2 (en) | 2014-04-16 | 2023-08-08 | Cilag Gmbh International | End effector arrangements comprising indicators |
US9844369B2 (en) | 2014-04-16 | 2017-12-19 | Ethicon Llc | Surgical end effectors with firing element monitoring arrangements |
US10542988B2 (en) | 2014-04-16 | 2020-01-28 | Ethicon Llc | End effector comprising an anvil including projections extending therefrom |
US10010324B2 (en) | 2014-04-16 | 2018-07-03 | Ethicon Llc | Fastener cartridge compromising fastener cavities including fastener control features |
US10470768B2 (en) | 2014-04-16 | 2019-11-12 | Ethicon Llc | Fastener cartridge including a layer attached thereto |
US11883026B2 (en) | 2014-04-16 | 2024-01-30 | Cilag Gmbh International | Fastener cartridge assemblies and staple retainer cover arrangements |
US10561422B2 (en) | 2014-04-16 | 2020-02-18 | Ethicon Llc | Fastener cartridge comprising deployable tissue engaging members |
US9833241B2 (en) | 2014-04-16 | 2017-12-05 | Ethicon Llc | Surgical fastener cartridges with driver stabilizing arrangements |
WO2015169949A1 (en) * | 2014-05-08 | 2015-11-12 | Image Engineering Gmbh & Co. Kg | Lighting device |
EP2942617A1 (en) * | 2014-05-08 | 2015-11-11 | Image Engineering GmbH & Co. KG | Illumination device |
CN106574865A (en) * | 2014-05-08 | 2017-04-19 | 图像工程有限两合公司 | Lighting device |
US10045781B2 (en) | 2014-06-13 | 2018-08-14 | Ethicon Llc | Closure lockout systems for surgical instruments |
US10283929B2 (en) * | 2014-07-10 | 2019-05-07 | Osram Opto Semiconductors Gmbh | Semiconductor laser device and camera |
WO2016005150A1 (en) * | 2014-07-10 | 2016-01-14 | Osram Opto Semiconductors Gmbh | Semiconductor laser device and camera |
US20170170625A1 (en) * | 2014-07-10 | 2017-06-15 | Osram Opto Semiconductors Gmbh | Semiconductor laser device and camera |
US11389162B2 (en) | 2014-09-05 | 2022-07-19 | Cilag Gmbh International | Smart cartridge wake up operation and data retention |
US11311294B2 (en) | 2014-09-05 | 2022-04-26 | Cilag Gmbh International | Powered medical device including measurement of closure state of jaws |
US9737301B2 (en) | 2014-09-05 | 2017-08-22 | Ethicon Llc | Monitoring device degradation based on component evaluation |
US10016199B2 (en) | 2014-09-05 | 2018-07-10 | Ethicon Llc | Polarity of hall magnet to identify cartridge type |
US10905423B2 (en) | 2014-09-05 | 2021-02-02 | Ethicon Llc | Smart cartridge wake up operation and data retention |
US10111679B2 (en) | 2014-09-05 | 2018-10-30 | Ethicon Llc | Circuitry and sensors for powered medical device |
US11406386B2 (en) | 2014-09-05 | 2022-08-09 | Cilag Gmbh International | End effector including magnetic and impedance sensors |
US11653918B2 (en) | 2014-09-05 | 2023-05-23 | Cilag Gmbh International | Local display of tissue parameter stabilization |
US11076854B2 (en) | 2014-09-05 | 2021-08-03 | Cilag Gmbh International | Smart cartridge wake up operation and data retention |
US11717297B2 (en) | 2014-09-05 | 2023-08-08 | Cilag Gmbh International | Smart cartridge wake up operation and data retention |
US10135242B2 (en) | 2014-09-05 | 2018-11-20 | Ethicon Llc | Smart cartridge wake up operation and data retention |
US9788836B2 (en) | 2014-09-05 | 2017-10-17 | Ethicon Llc | Multiple motor control for powered medical device |
US9724094B2 (en) | 2014-09-05 | 2017-08-08 | Ethicon Llc | Adjunct with integrated sensors to quantify tissue compression |
US11071545B2 (en) | 2014-09-05 | 2021-07-27 | Cilag Gmbh International | Smart cartridge wake up operation and data retention |
US9757128B2 (en) | 2014-09-05 | 2017-09-12 | Ethicon Llc | Multiple sensors with one sensor affecting a second sensor's output or interpretation |
US11284898B2 (en) | 2014-09-18 | 2022-03-29 | Cilag Gmbh International | Surgical instrument including a deployable knife |
US11523821B2 (en) | 2014-09-26 | 2022-12-13 | Cilag Gmbh International | Method for creating a flexible staple line |
US10206677B2 (en) | 2014-09-26 | 2019-02-19 | Ethicon Llc | Surgical staple and driver arrangements for staple cartridges |
US10426476B2 (en) | 2014-09-26 | 2019-10-01 | Ethicon Llc | Circular fastener cartridges for applying radially expandable fastener lines |
US10751053B2 (en) | 2014-09-26 | 2020-08-25 | Ethicon Llc | Fastener cartridges for applying expandable fastener lines |
US10426477B2 (en) | 2014-09-26 | 2019-10-01 | Ethicon Llc | Staple cartridge assembly including a ramp |
US9801628B2 (en) | 2014-09-26 | 2017-10-31 | Ethicon Llc | Surgical staple and driver arrangements for staple cartridges |
US9801627B2 (en) | 2014-09-26 | 2017-10-31 | Ethicon Llc | Fastener cartridge for creating a flexible staple line |
US10327764B2 (en) | 2014-09-26 | 2019-06-25 | Ethicon Llc | Method for creating a flexible staple line |
US11202633B2 (en) | 2014-09-26 | 2021-12-21 | Cilag Gmbh International | Surgical stapling buttresses and adjunct materials |
US10076325B2 (en) | 2014-10-13 | 2018-09-18 | Ethicon Llc | Surgical stapling apparatus comprising a tissue stop |
US10736630B2 (en) | 2014-10-13 | 2020-08-11 | Ethicon Llc | Staple cartridge |
US11931031B2 (en) | 2014-10-16 | 2024-03-19 | Cilag Gmbh International | Staple cartridge comprising a deck including an upper surface and a lower surface |
US11185325B2 (en) | 2014-10-16 | 2021-11-30 | Cilag Gmbh International | End effector including different tissue gaps |
US11918210B2 (en) | 2014-10-16 | 2024-03-05 | Cilag Gmbh International | Staple cartridge comprising a cartridge body including a plurality of wells |
US9924944B2 (en) | 2014-10-16 | 2018-03-27 | Ethicon Llc | Staple cartridge comprising an adjunct material |
US11701114B2 (en) | 2014-10-16 | 2023-07-18 | Cilag Gmbh International | Staple cartridge |
US10052104B2 (en) | 2014-10-16 | 2018-08-21 | Ethicon Llc | Staple cartridge comprising a tissue thickness compensator |
US10905418B2 (en) | 2014-10-16 | 2021-02-02 | Ethicon Llc | Staple cartridge comprising a tissue thickness compensator |
US10517594B2 (en) | 2014-10-29 | 2019-12-31 | Ethicon Llc | Cartridge assemblies for surgical staplers |
US11864760B2 (en) | 2014-10-29 | 2024-01-09 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
US11931038B2 (en) | 2014-10-29 | 2024-03-19 | Cilag Gmbh International | Cartridge assemblies for surgical staplers |
US11457918B2 (en) | 2014-10-29 | 2022-10-04 | Cilag Gmbh International | Cartridge assemblies for surgical staplers |
US11241229B2 (en) | 2014-10-29 | 2022-02-08 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
US11141153B2 (en) | 2014-10-29 | 2021-10-12 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
US10617417B2 (en) | 2014-11-06 | 2020-04-14 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
US11337698B2 (en) | 2014-11-06 | 2022-05-24 | Cilag Gmbh International | Staple cartridge comprising a releasable adjunct material |
US9844376B2 (en) | 2014-11-06 | 2017-12-19 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
US10736636B2 (en) | 2014-12-10 | 2020-08-11 | Ethicon Llc | Articulatable surgical instrument system |
US11382628B2 (en) | 2014-12-10 | 2022-07-12 | Cilag Gmbh International | Articulatable surgical instrument system |
US10004501B2 (en) | 2014-12-18 | 2018-06-26 | Ethicon Llc | Surgical instruments with improved closure arrangements |
US10245027B2 (en) | 2014-12-18 | 2019-04-02 | Ethicon Llc | Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge |
US11553911B2 (en) | 2014-12-18 | 2023-01-17 | Cilag Gmbh International | Surgical instrument assembly comprising a flexible articulation system |
US10743873B2 (en) | 2014-12-18 | 2020-08-18 | Ethicon Llc | Drive arrangements for articulatable surgical instruments |
US11547403B2 (en) | 2014-12-18 | 2023-01-10 | Cilag Gmbh International | Surgical instrument having a laminate firing actuator and lateral buckling supports |
US11678877B2 (en) | 2014-12-18 | 2023-06-20 | Cilag Gmbh International | Surgical instrument including a flexible support configured to support a flexible firing member |
US11547404B2 (en) | 2014-12-18 | 2023-01-10 | Cilag Gmbh International | Surgical instrument assembly comprising a flexible articulation system |
US11571207B2 (en) | 2014-12-18 | 2023-02-07 | Cilag Gmbh International | Surgical system including lateral supports for a flexible drive member |
US11517311B2 (en) | 2014-12-18 | 2022-12-06 | Cilag Gmbh International | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
US10695058B2 (en) | 2014-12-18 | 2020-06-30 | Ethicon Llc | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
US10806448B2 (en) | 2014-12-18 | 2020-10-20 | Ethicon Llc | Surgical instrument assembly comprising a flexible articulation system |
US9943309B2 (en) | 2014-12-18 | 2018-04-17 | Ethicon Llc | Surgical instruments with articulatable end effectors and movable firing beam support arrangements |
US11812958B2 (en) | 2014-12-18 | 2023-11-14 | Cilag Gmbh International | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
US10117649B2 (en) | 2014-12-18 | 2018-11-06 | Ethicon Llc | Surgical instrument assembly comprising a lockable articulation system |
US10085748B2 (en) | 2014-12-18 | 2018-10-02 | Ethicon Llc | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
US9968355B2 (en) | 2014-12-18 | 2018-05-15 | Ethicon Llc | Surgical instruments with articulatable end effectors and improved firing beam support arrangements |
US9987000B2 (en) | 2014-12-18 | 2018-06-05 | Ethicon Llc | Surgical instrument assembly comprising a flexible articulation system |
US10945728B2 (en) | 2014-12-18 | 2021-03-16 | Ethicon Llc | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
US9844375B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Drive arrangements for articulatable surgical instruments |
US10188385B2 (en) | 2014-12-18 | 2019-01-29 | Ethicon Llc | Surgical instrument system comprising lockable systems |
US9844374B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
US11083453B2 (en) | 2014-12-18 | 2021-08-10 | Cilag Gmbh International | Surgical stapling system including a flexible firing actuator and lateral buckling supports |
US11399831B2 (en) | 2014-12-18 | 2022-08-02 | Cilag Gmbh International | Drive arrangements for articulatable surgical instruments |
US11744588B2 (en) | 2015-02-27 | 2023-09-05 | Cilag Gmbh International | Surgical stapling instrument including a removably attachable battery pack |
US9993258B2 (en) | 2015-02-27 | 2018-06-12 | Ethicon Llc | Adaptable surgical instrument handle |
US20160249910A1 (en) * | 2015-02-27 | 2016-09-01 | Ethicon Endo-Surgery, Llc | Surgical charging system that charges and/or conditions one or more batteries |
US10045779B2 (en) | 2015-02-27 | 2018-08-14 | Ethicon Llc | Surgical instrument system comprising an inspection station |
US10159483B2 (en) | 2015-02-27 | 2018-12-25 | Ethicon Llc | Surgical apparatus configured to track an end-of-life parameter |
US10182816B2 (en) | 2015-02-27 | 2019-01-22 | Ethicon Llc | Charging system that enables emergency resolutions for charging a battery |
US10321907B2 (en) | 2015-02-27 | 2019-06-18 | Ethicon Llc | System for monitoring whether a surgical instrument needs to be serviced |
US11154301B2 (en) | 2015-02-27 | 2021-10-26 | Cilag Gmbh International | Modular stapling assembly |
US9931118B2 (en) | 2015-02-27 | 2018-04-03 | Ethicon Endo-Surgery, Llc | Reinforced battery for a surgical instrument |
US10226250B2 (en) | 2015-02-27 | 2019-03-12 | Ethicon Llc | Modular stapling assembly |
US10245028B2 (en) | 2015-02-27 | 2019-04-02 | Ethicon Llc | Power adapter for a surgical instrument |
US11324506B2 (en) | 2015-02-27 | 2022-05-10 | Cilag Gmbh International | Modular stapling assembly |
US10180463B2 (en) | 2015-02-27 | 2019-01-15 | Ethicon Llc | Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band |
US10772625B2 (en) | 2015-03-06 | 2020-09-15 | Ethicon Llc | Signal and power communication system positioned on a rotatable shaft |
US10729432B2 (en) | 2015-03-06 | 2020-08-04 | Ethicon Llc | Methods for operating a powered surgical instrument |
US10524787B2 (en) | 2015-03-06 | 2020-01-07 | Ethicon Llc | Powered surgical instrument with parameter-based firing rate |
US11224423B2 (en) | 2015-03-06 | 2022-01-18 | Cilag Gmbh International | Smart sensors with local signal processing |
US10045776B2 (en) | 2015-03-06 | 2018-08-14 | Ethicon Llc | Control techniques and sub-processor contained within modular shaft with select control processing from handle |
US9808246B2 (en) | 2015-03-06 | 2017-11-07 | Ethicon Endo-Surgery, Llc | Method of operating a powered surgical instrument |
US10531887B2 (en) | 2015-03-06 | 2020-01-14 | Ethicon Llc | Powered surgical instrument including speed display |
US11944338B2 (en) | 2015-03-06 | 2024-04-02 | Cilag Gmbh International | Multiple level thresholds to modify operation of powered surgical instruments |
US10966627B2 (en) | 2015-03-06 | 2021-04-06 | Ethicon Llc | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US9895148B2 (en) | 2015-03-06 | 2018-02-20 | Ethicon Endo-Surgery, Llc | Monitoring speed control and precision incrementing of motor for powered surgical instruments |
US10548504B2 (en) | 2015-03-06 | 2020-02-04 | Ethicon Llc | Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression |
US10617412B2 (en) | 2015-03-06 | 2020-04-14 | Ethicon Llc | System for detecting the mis-insertion of a staple cartridge into a surgical stapler |
US11109859B2 (en) | 2015-03-06 | 2021-09-07 | Cilag Gmbh International | Surgical instrument comprising a lockable battery housing |
US11426160B2 (en) | 2015-03-06 | 2022-08-30 | Cilag Gmbh International | Smart sensors with local signal processing |
US10206605B2 (en) | 2015-03-06 | 2019-02-19 | Ethicon Llc | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US9901342B2 (en) | 2015-03-06 | 2018-02-27 | Ethicon Endo-Surgery, Llc | Signal and power communication system positioned on a rotatable shaft |
US10245033B2 (en) | 2015-03-06 | 2019-04-02 | Ethicon Llc | Surgical instrument comprising a lockable battery housing |
US11826132B2 (en) | 2015-03-06 | 2023-11-28 | Cilag Gmbh International | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US11350843B2 (en) | 2015-03-06 | 2022-06-07 | Cilag Gmbh International | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US10052044B2 (en) | 2015-03-06 | 2018-08-21 | Ethicon Llc | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
US10687806B2 (en) | 2015-03-06 | 2020-06-23 | Ethicon Llc | Adaptive tissue compression techniques to adjust closure rates for multiple tissue types |
US9924961B2 (en) | 2015-03-06 | 2018-03-27 | Ethicon Endo-Surgery, Llc | Interactive feedback system for powered surgical instruments |
WO2016154343A1 (en) * | 2015-03-23 | 2016-09-29 | Akari Systems, Inc. | Methods of application of therapeutic light sources |
US10213201B2 (en) | 2015-03-31 | 2019-02-26 | Ethicon Llc | Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw |
US10390825B2 (en) | 2015-03-31 | 2019-08-27 | Ethicon Llc | Surgical instrument with progressive rotary drive systems |
US11918212B2 (en) | 2015-03-31 | 2024-03-05 | Cilag Gmbh International | Surgical instrument with selectively disengageable drive systems |
US10433844B2 (en) | 2015-03-31 | 2019-10-08 | Ethicon Llc | Surgical instrument with selectively disengageable threaded drive systems |
WO2016171639A1 (en) * | 2015-04-24 | 2016-10-27 | Robin Kozmetik Guzellik Merkezi Medikal Ozel Egitim Ogretim Metal Urunleri Temizlik Urun Ve Gida Maddeleri Ithalat Ihracat Sanayi Ticaret Ltd. Sti. | A selective photothermolysis epilation device |
US10052102B2 (en) | 2015-06-18 | 2018-08-21 | Ethicon Llc | Surgical end effectors with dual cam actuated jaw closing features |
US10617418B2 (en) | 2015-08-17 | 2020-04-14 | Ethicon Llc | Implantable layers for a surgical instrument |
US11058425B2 (en) | 2015-08-17 | 2021-07-13 | Ethicon Llc | Implantable layers for a surgical instrument |
US10835249B2 (en) | 2015-08-17 | 2020-11-17 | Ethicon Llc | Implantable layers for a surgical instrument |
US10433845B2 (en) | 2015-08-26 | 2019-10-08 | Ethicon Llc | Surgical staple strips for permitting varying staple properties and enabling easy cartridge loading |
US10390829B2 (en) | 2015-08-26 | 2019-08-27 | Ethicon Llc | Staples comprising a cover |
US10098642B2 (en) | 2015-08-26 | 2018-10-16 | Ethicon Llc | Surgical staples comprising features for improved fastening of tissue |
US11849946B2 (en) | 2015-09-23 | 2023-12-26 | Cilag Gmbh International | Surgical stapler having downstream current-based motor control |
US10105139B2 (en) | 2015-09-23 | 2018-10-23 | Ethicon Llc | Surgical stapler having downstream current-based motor control |
US11026678B2 (en) | 2015-09-23 | 2021-06-08 | Cilag Gmbh International | Surgical stapler having motor control based on an electrical parameter related to a motor current |
US10238386B2 (en) | 2015-09-23 | 2019-03-26 | Ethicon Llc | Surgical stapler having motor control based on an electrical parameter related to a motor current |
US11490889B2 (en) | 2015-09-23 | 2022-11-08 | Cilag Gmbh International | Surgical stapler having motor control based on an electrical parameter related to a motor current |
US11344299B2 (en) | 2015-09-23 | 2022-05-31 | Cilag Gmbh International | Surgical stapler having downstream current-based motor control |
US10363036B2 (en) | 2015-09-23 | 2019-07-30 | Ethicon Llc | Surgical stapler having force-based motor control |
US10327769B2 (en) | 2015-09-23 | 2019-06-25 | Ethicon Llc | Surgical stapler having motor control based on a drive system component |
US10076326B2 (en) | 2015-09-23 | 2018-09-18 | Ethicon Llc | Surgical stapler having current mirror-based motor control |
US10863986B2 (en) | 2015-09-23 | 2020-12-15 | Ethicon Llc | Surgical stapler having downstream current-based motor control |
US10085751B2 (en) | 2015-09-23 | 2018-10-02 | Ethicon Llc | Surgical stapler having temperature-based motor control |
US10299878B2 (en) | 2015-09-25 | 2019-05-28 | Ethicon Llc | Implantable adjunct systems for determining adjunct skew |
US11076929B2 (en) | 2015-09-25 | 2021-08-03 | Cilag Gmbh International | Implantable adjunct systems for determining adjunct skew |
US10736633B2 (en) | 2015-09-30 | 2020-08-11 | Ethicon Llc | Compressible adjunct with looping members |
US11793522B2 (en) | 2015-09-30 | 2023-10-24 | Cilag Gmbh International | Staple cartridge assembly including a compressible adjunct |
US10524788B2 (en) | 2015-09-30 | 2020-01-07 | Ethicon Llc | Compressible adjunct with attachment regions |
US10603039B2 (en) | 2015-09-30 | 2020-03-31 | Ethicon Llc | Progressively releasable implantable adjunct for use with a surgical stapling instrument |
US10932779B2 (en) | 2015-09-30 | 2021-03-02 | Ethicon Llc | Compressible adjunct with crossing spacer fibers |
US11903586B2 (en) | 2015-09-30 | 2024-02-20 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
US10307160B2 (en) | 2015-09-30 | 2019-06-04 | Ethicon Llc | Compressible adjunct assemblies with attachment layers |
US11890015B2 (en) | 2015-09-30 | 2024-02-06 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
US10271849B2 (en) | 2015-09-30 | 2019-04-30 | Ethicon Llc | Woven constructs with interlocked standing fibers |
US10561420B2 (en) | 2015-09-30 | 2020-02-18 | Ethicon Llc | Tubular absorbable constructs |
US11944308B2 (en) | 2015-09-30 | 2024-04-02 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
US10327777B2 (en) | 2015-09-30 | 2019-06-25 | Ethicon Llc | Implantable layer comprising plastically deformed fibers |
US11553916B2 (en) | 2015-09-30 | 2023-01-17 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
US11690623B2 (en) | 2015-09-30 | 2023-07-04 | Cilag Gmbh International | Method for applying an implantable layer to a fastener cartridge |
US10433846B2 (en) | 2015-09-30 | 2019-10-08 | Ethicon Llc | Compressible adjunct with crossing spacer fibers |
US10172620B2 (en) | 2015-09-30 | 2019-01-08 | Ethicon Llc | Compressible adjuncts with bonding nodes |
US10980539B2 (en) | 2015-09-30 | 2021-04-20 | Ethicon Llc | Implantable adjunct comprising bonded layers |
US10285699B2 (en) | 2015-09-30 | 2019-05-14 | Ethicon Llc | Compressible adjunct |
US10478188B2 (en) | 2015-09-30 | 2019-11-19 | Ethicon Llc | Implantable layer comprising a constricted configuration |
US11712244B2 (en) | 2015-09-30 | 2023-08-01 | Cilag Gmbh International | Implantable layer with spacer fibers |
US11759208B2 (en) | 2015-12-30 | 2023-09-19 | Cilag Gmbh International | Mechanisms for compensating for battery pack failure in powered surgical instruments |
US10292704B2 (en) | 2015-12-30 | 2019-05-21 | Ethicon Llc | Mechanisms for compensating for battery pack failure in powered surgical instruments |
US11058422B2 (en) | 2015-12-30 | 2021-07-13 | Cilag Gmbh International | Mechanisms for compensating for battery pack failure in powered surgical instruments |
US11484309B2 (en) | 2015-12-30 | 2022-11-01 | Cilag Gmbh International | Surgical stapling system comprising a controller configured to cause a motor to reset a firing sequence |
US11129613B2 (en) | 2015-12-30 | 2021-09-28 | Cilag Gmbh International | Surgical instruments with separable motors and motor control circuits |
US10368865B2 (en) | 2015-12-30 | 2019-08-06 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10265068B2 (en) | 2015-12-30 | 2019-04-23 | Ethicon Llc | Surgical instruments with separable motors and motor control circuits |
US11083454B2 (en) | 2015-12-30 | 2021-08-10 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10413291B2 (en) | 2016-02-09 | 2019-09-17 | Ethicon Llc | Surgical instrument articulation mechanism with slotted secondary constraint |
US10653413B2 (en) | 2016-02-09 | 2020-05-19 | Ethicon Llc | Surgical instruments with an end effector that is highly articulatable relative to an elongate shaft assembly |
US11213293B2 (en) | 2016-02-09 | 2022-01-04 | Cilag Gmbh International | Articulatable surgical instruments with single articulation link arrangements |
US11523823B2 (en) | 2016-02-09 | 2022-12-13 | Cilag Gmbh International | Surgical instruments with non-symmetrical articulation arrangements |
US10245029B2 (en) | 2016-02-09 | 2019-04-02 | Ethicon Llc | Surgical instrument with articulating and axially translatable end effector |
US10470764B2 (en) | 2016-02-09 | 2019-11-12 | Ethicon Llc | Surgical instruments with closure stroke reduction arrangements |
US10588625B2 (en) | 2016-02-09 | 2020-03-17 | Ethicon Llc | Articulatable surgical instruments with off-axis firing beam arrangements |
US10245030B2 (en) | 2016-02-09 | 2019-04-02 | Ethicon Llc | Surgical instruments with tensioning arrangements for cable driven articulation systems |
US11730471B2 (en) | 2016-02-09 | 2023-08-22 | Cilag Gmbh International | Articulatable surgical instruments with single articulation link arrangements |
US10433837B2 (en) | 2016-02-09 | 2019-10-08 | Ethicon Llc | Surgical instruments with multiple link articulation arrangements |
US11224426B2 (en) | 2016-02-12 | 2022-01-18 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10448948B2 (en) | 2016-02-12 | 2019-10-22 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US11344303B2 (en) | 2016-02-12 | 2022-05-31 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10258331B2 (en) | 2016-02-12 | 2019-04-16 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US11826045B2 (en) | 2016-02-12 | 2023-11-28 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US11779336B2 (en) | 2016-02-12 | 2023-10-10 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
US10617413B2 (en) | 2016-04-01 | 2020-04-14 | Ethicon Llc | Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts |
US10376263B2 (en) | 2016-04-01 | 2019-08-13 | Ethicon Llc | Anvil modification members for surgical staplers |
US11771454B2 (en) | 2016-04-15 | 2023-10-03 | Cilag Gmbh International | Stapling assembly including a controller for monitoring a clamping laod |
US11051810B2 (en) | 2016-04-15 | 2021-07-06 | Cilag Gmbh International | Modular surgical instrument with configurable operating mode |
US10335145B2 (en) | 2016-04-15 | 2019-07-02 | Ethicon Llc | Modular surgical instrument with configurable operating mode |
US11284891B2 (en) | 2016-04-15 | 2022-03-29 | Cilag Gmbh International | Surgical instrument with multiple program responses during a firing motion |
US11931028B2 (en) | 2016-04-15 | 2024-03-19 | Cilag Gmbh International | Surgical instrument with multiple program responses during a firing motion |
US11026684B2 (en) | 2016-04-15 | 2021-06-08 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US11350932B2 (en) | 2016-04-15 | 2022-06-07 | Cilag Gmbh International | Surgical instrument with improved stop/start control during a firing motion |
US10492783B2 (en) | 2016-04-15 | 2019-12-03 | Ethicon, Llc | Surgical instrument with improved stop/start control during a firing motion |
US10405859B2 (en) | 2016-04-15 | 2019-09-10 | Ethicon Llc | Surgical instrument with adjustable stop/start control during a firing motion |
US11191545B2 (en) | 2016-04-15 | 2021-12-07 | Cilag Gmbh International | Staple formation detection mechanisms |
US10828028B2 (en) | 2016-04-15 | 2020-11-10 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US10456137B2 (en) | 2016-04-15 | 2019-10-29 | Ethicon Llc | Staple formation detection mechanisms |
US10357247B2 (en) | 2016-04-15 | 2019-07-23 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
US11607239B2 (en) | 2016-04-15 | 2023-03-21 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US11179150B2 (en) | 2016-04-15 | 2021-11-23 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
US10426467B2 (en) | 2016-04-15 | 2019-10-01 | Ethicon Llc | Surgical instrument with detection sensors |
US11517306B2 (en) | 2016-04-15 | 2022-12-06 | Cilag Gmbh International | Surgical instrument with detection sensors |
US11642125B2 (en) | 2016-04-15 | 2023-05-09 | Cilag Gmbh International | Robotic surgical system including a user interface and a control circuit |
US11317910B2 (en) | 2016-04-15 | 2022-05-03 | Cilag Gmbh International | Surgical instrument with detection sensors |
US11311292B2 (en) | 2016-04-15 | 2022-04-26 | Cilag Gmbh International | Surgical instrument with detection sensors |
US10363037B2 (en) | 2016-04-18 | 2019-07-30 | Ethicon Llc | Surgical instrument system comprising a magnetic lockout |
US11317917B2 (en) | 2016-04-18 | 2022-05-03 | Cilag Gmbh International | Surgical stapling system comprising a lockable firing assembly |
US10368867B2 (en) | 2016-04-18 | 2019-08-06 | Ethicon Llc | Surgical instrument comprising a lockout |
US11350928B2 (en) | 2016-04-18 | 2022-06-07 | Cilag Gmbh International | Surgical instrument comprising a tissue thickness lockout and speed control system |
US11559303B2 (en) | 2016-04-18 | 2023-01-24 | Cilag Gmbh International | Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments |
US10478181B2 (en) | 2016-04-18 | 2019-11-19 | Ethicon Llc | Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments |
US10426469B2 (en) | 2016-04-18 | 2019-10-01 | Ethicon Llc | Surgical instrument comprising a primary firing lockout and a secondary firing lockout |
US11811253B2 (en) | 2016-04-18 | 2023-11-07 | Cilag Gmbh International | Surgical robotic system with fault state detection configurations based on motor current draw |
US11147554B2 (en) | 2016-04-18 | 2021-10-19 | Cilag Gmbh International | Surgical instrument system comprising a magnetic lockout |
US10433840B2 (en) | 2016-04-18 | 2019-10-08 | Ethicon Llc | Surgical instrument comprising a replaceable cartridge jaw |
US10835247B2 (en) | 2016-12-21 | 2020-11-17 | Ethicon Llc | Lockout arrangements for surgical end effectors |
US11653917B2 (en) | 2016-12-21 | 2023-05-23 | Cilag Gmbh International | Surgical stapling systems |
US11701115B2 (en) | 2016-12-21 | 2023-07-18 | Cilag Gmbh International | Methods of stapling tissue |
US10918385B2 (en) | 2016-12-21 | 2021-02-16 | Ethicon Llc | Surgical system comprising a firing member rotatable into an articulation state to articulate an end effector of the surgical system |
US11350934B2 (en) | 2016-12-21 | 2022-06-07 | Cilag Gmbh International | Staple forming pocket arrangement to accommodate different types of staples |
US11350935B2 (en) | 2016-12-21 | 2022-06-07 | Cilag Gmbh International | Surgical tool assemblies with closure stroke reduction features |
US11564688B2 (en) | 2016-12-21 | 2023-01-31 | Cilag Gmbh International | Robotic surgical tool having a retraction mechanism |
US11134942B2 (en) | 2016-12-21 | 2021-10-05 | Cilag Gmbh International | Surgical stapling instruments and staple-forming anvils |
US10905422B2 (en) | 2016-12-21 | 2021-02-02 | Ethicon Llc | Surgical instrument for use with a robotic surgical system |
US10588631B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical instruments with positive jaw opening features |
US10582928B2 (en) | 2016-12-21 | 2020-03-10 | Ethicon Llc | Articulation lock arrangements for locking an end effector in an articulated position in response to actuation of a jaw closure system |
US10898186B2 (en) | 2016-12-21 | 2021-01-26 | Ethicon Llc | Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls |
US11369376B2 (en) | 2016-12-21 | 2022-06-28 | Cilag Gmbh International | Surgical stapling systems |
US10736629B2 (en) | 2016-12-21 | 2020-08-11 | Ethicon Llc | Surgical tool assemblies with clutching arrangements for shifting between closure systems with closure stroke reduction features and articulation and firing systems |
US11317913B2 (en) | 2016-12-21 | 2022-05-03 | Cilag Gmbh International | Lockout arrangements for surgical end effectors and replaceable tool assemblies |
US10568625B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Staple cartridges and arrangements of staples and staple cavities therein |
US10893864B2 (en) | 2016-12-21 | 2021-01-19 | Ethicon | Staple cartridges and arrangements of staples and staple cavities therein |
US10888322B2 (en) | 2016-12-21 | 2021-01-12 | Ethicon Llc | Surgical instrument comprising a cutting member |
US11191540B2 (en) | 2016-12-21 | 2021-12-07 | Cilag Gmbh International | Protective cover arrangements for a joint interface between a movable jaw and actuator shaft of a surgical instrument |
US10492785B2 (en) | 2016-12-21 | 2019-12-03 | Ethicon Llc | Shaft assembly comprising a lockout |
US10588632B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical end effectors and firing members thereof |
US10588630B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical tool assemblies with closure stroke reduction features |
US11571210B2 (en) | 2016-12-21 | 2023-02-07 | Cilag Gmbh International | Firing assembly comprising a multiple failed-state fuse |
US10485543B2 (en) | 2016-12-21 | 2019-11-26 | Ethicon Llc | Anvil having a knife slot width |
US10881401B2 (en) | 2016-12-21 | 2021-01-05 | Ethicon Llc | Staple firing member comprising a missing cartridge and/or spent cartridge lockout |
US10499914B2 (en) | 2016-12-21 | 2019-12-10 | Ethicon Llc | Staple forming pocket arrangements |
US10568624B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems |
US10568626B2 (en) | 2016-12-21 | 2020-02-25 | Ethicon Llc | Surgical instruments with jaw opening features for increasing a jaw opening distance |
US11931034B2 (en) | 2016-12-21 | 2024-03-19 | Cilag Gmbh International | Surgical stapling instruments with smart staple cartridges |
US10695055B2 (en) | 2016-12-21 | 2020-06-30 | Ethicon Llc | Firing assembly comprising a lockout |
US11224428B2 (en) | 2016-12-21 | 2022-01-18 | Cilag Gmbh International | Surgical stapling systems |
US11096689B2 (en) | 2016-12-21 | 2021-08-24 | Cilag Gmbh International | Shaft assembly comprising a lockout |
US10758230B2 (en) | 2016-12-21 | 2020-09-01 | Ethicon Llc | Surgical instrument with primary and safety processors |
US10758229B2 (en) | 2016-12-21 | 2020-09-01 | Ethicon Llc | Surgical instrument comprising improved jaw control |
US10856868B2 (en) | 2016-12-21 | 2020-12-08 | Ethicon Llc | Firing member pin configurations |
US11419606B2 (en) | 2016-12-21 | 2022-08-23 | Cilag Gmbh International | Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems |
US10603036B2 (en) | 2016-12-21 | 2020-03-31 | Ethicon Llc | Articulatable surgical instrument with independent pivotable linkage distal of an articulation lock |
US10959727B2 (en) | 2016-12-21 | 2021-03-30 | Ethicon Llc | Articulatable surgical end effector with asymmetric shaft arrangement |
US10517596B2 (en) | 2016-12-21 | 2019-12-31 | Ethicon Llc | Articulatable surgical instruments with articulation stroke amplification features |
US10687809B2 (en) | 2016-12-21 | 2020-06-23 | Ethicon Llc | Surgical staple cartridge with movable camming member configured to disengage firing member lockout features |
US10610224B2 (en) | 2016-12-21 | 2020-04-07 | Ethicon Llc | Lockout arrangements for surgical end effectors and replaceable tool assemblies |
US11191543B2 (en) | 2016-12-21 | 2021-12-07 | Cilag Gmbh International | Assembly comprising a lock |
US10448950B2 (en) | 2016-12-21 | 2019-10-22 | Ethicon Llc | Surgical staplers with independently actuatable closing and firing systems |
US10973516B2 (en) | 2016-12-21 | 2021-04-13 | Ethicon Llc | Surgical end effectors and adaptable firing members therefor |
US11090048B2 (en) | 2016-12-21 | 2021-08-17 | Cilag Gmbh International | Method for resetting a fuse of a surgical instrument shaft |
US10542982B2 (en) | 2016-12-21 | 2020-01-28 | Ethicon Llc | Shaft assembly comprising first and second articulation lockouts |
US10835245B2 (en) | 2016-12-21 | 2020-11-17 | Ethicon Llc | Method for attaching a shaft assembly to a surgical instrument and, alternatively, to a surgical robot |
US10517595B2 (en) | 2016-12-21 | 2019-12-31 | Ethicon Llc | Jaw actuated lock arrangements for preventing advancement of a firing member in a surgical end effector unless an unfired cartridge is installed in the end effector |
US10682138B2 (en) | 2016-12-21 | 2020-06-16 | Ethicon Llc | Bilaterally asymmetric staple forming pocket pairs |
US11849948B2 (en) | 2016-12-21 | 2023-12-26 | Cilag Gmbh International | Method for resetting a fuse of a surgical instrument shaft |
US10980536B2 (en) | 2016-12-21 | 2021-04-20 | Ethicon Llc | No-cartridge and spent cartridge lockout arrangements for surgical staplers |
US10675025B2 (en) | 2016-12-21 | 2020-06-09 | Ethicon Llc | Shaft assembly comprising separately actuatable and retractable systems |
US10537325B2 (en) | 2016-12-21 | 2020-01-21 | Ethicon Llc | Staple forming pocket arrangement to accommodate different types of staples |
US11191539B2 (en) | 2016-12-21 | 2021-12-07 | Cilag Gmbh International | Shaft assembly comprising a manually-operable retraction system for use with a motorized surgical instrument system |
US10617414B2 (en) | 2016-12-21 | 2020-04-14 | Ethicon Llc | Closure member arrangements for surgical instruments |
US11160551B2 (en) | 2016-12-21 | 2021-11-02 | Cilag Gmbh International | Articulatable surgical stapling instruments |
US11918215B2 (en) | 2016-12-21 | 2024-03-05 | Cilag Gmbh International | Staple cartridge with array of staple pockets |
US10675026B2 (en) | 2016-12-21 | 2020-06-09 | Ethicon Llc | Methods of stapling tissue |
US11766259B2 (en) | 2016-12-21 | 2023-09-26 | Cilag Gmbh International | Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument |
US10624635B2 (en) | 2016-12-21 | 2020-04-21 | Ethicon Llc | Firing members with non-parallel jaw engagement features for surgical end effectors |
US10667809B2 (en) | 2016-12-21 | 2020-06-02 | Ethicon Llc | Staple cartridge and staple cartridge channel comprising windows defined therein |
US11179155B2 (en) | 2016-12-21 | 2021-11-23 | Cilag Gmbh International | Anvil arrangements for surgical staplers |
US10813638B2 (en) | 2016-12-21 | 2020-10-27 | Ethicon Llc | Surgical end effectors with expandable tissue stop arrangements |
US11160553B2 (en) | 2016-12-21 | 2021-11-02 | Cilag Gmbh International | Surgical stapling systems |
US11497499B2 (en) | 2016-12-21 | 2022-11-15 | Cilag Gmbh International | Articulatable surgical stapling instruments |
US10426471B2 (en) | 2016-12-21 | 2019-10-01 | Ethicon Llc | Surgical instrument with multiple failure response modes |
US10639034B2 (en) | 2016-12-21 | 2020-05-05 | Ethicon Llc | Surgical instruments with lockout arrangements for preventing firing system actuation unless an unspent staple cartridge is present |
US10667810B2 (en) | 2016-12-21 | 2020-06-02 | Ethicon Llc | Closure members with cam surface arrangements for surgical instruments with separate and distinct closure and firing systems |
US11766260B2 (en) | 2016-12-21 | 2023-09-26 | Cilag Gmbh International | Methods of stapling tissue |
US10639035B2 (en) | 2016-12-21 | 2020-05-05 | Ethicon Llc | Surgical stapling instruments and replaceable tool assemblies thereof |
US10779823B2 (en) | 2016-12-21 | 2020-09-22 | Ethicon Llc | Firing member pin angle |
US10667811B2 (en) | 2016-12-21 | 2020-06-02 | Ethicon Llc | Surgical stapling instruments and staple-forming anvils |
US10524789B2 (en) | 2016-12-21 | 2020-01-07 | Ethicon Llc | Laterally actuatable articulation lock arrangements for locking an end effector of a surgical instrument in an articulated configuration |
US11672532B2 (en) | 2017-06-20 | 2023-06-13 | Cilag Gmbh International | Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument |
US10595882B2 (en) | 2017-06-20 | 2020-03-24 | Ethicon Llc | Methods for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US10888321B2 (en) | 2017-06-20 | 2021-01-12 | Ethicon Llc | Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument |
US11382638B2 (en) | 2017-06-20 | 2022-07-12 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance |
US10646220B2 (en) | 2017-06-20 | 2020-05-12 | Ethicon Llc | Systems and methods for controlling displacement member velocity for a surgical instrument |
US10881396B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Surgical instrument with variable duration trigger arrangement |
US10813639B2 (en) | 2017-06-20 | 2020-10-27 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions |
US11871939B2 (en) | 2017-06-20 | 2024-01-16 | Cilag Gmbh International | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US10624633B2 (en) | 2017-06-20 | 2020-04-21 | Ethicon Llc | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument |
US11071554B2 (en) | 2017-06-20 | 2021-07-27 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements |
US11793513B2 (en) | 2017-06-20 | 2023-10-24 | Cilag Gmbh International | Systems and methods for controlling motor speed according to user input for a surgical instrument |
US11653914B2 (en) | 2017-06-20 | 2023-05-23 | Cilag Gmbh International | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector |
US10980537B2 (en) | 2017-06-20 | 2021-04-20 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations |
US10307170B2 (en) | 2017-06-20 | 2019-06-04 | Ethicon Llc | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US11090046B2 (en) | 2017-06-20 | 2021-08-17 | Cilag Gmbh International | Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument |
US10390841B2 (en) | 2017-06-20 | 2019-08-27 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
USD890784S1 (en) | 2017-06-20 | 2020-07-21 | Ethicon Llc | Display panel with changeable graphical user interface |
US10779820B2 (en) | 2017-06-20 | 2020-09-22 | Ethicon Llc | Systems and methods for controlling motor speed according to user input for a surgical instrument |
US11517325B2 (en) | 2017-06-20 | 2022-12-06 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval |
US10368864B2 (en) | 2017-06-20 | 2019-08-06 | Ethicon Llc | Systems and methods for controlling displaying motor velocity for a surgical instrument |
USD879809S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with changeable graphical user interface |
USD879808S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with graphical user interface |
US10327767B2 (en) | 2017-06-20 | 2019-06-25 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
US11213302B2 (en) | 2017-06-20 | 2022-01-04 | Cilag Gmbh International | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
US10881399B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument |
US10772629B2 (en) | 2017-06-27 | 2020-09-15 | Ethicon Llc | Surgical anvil arrangements |
US11766258B2 (en) | 2017-06-27 | 2023-09-26 | Cilag Gmbh International | Surgical anvil arrangements |
US10993716B2 (en) | 2017-06-27 | 2021-05-04 | Ethicon Llc | Surgical anvil arrangements |
US10856869B2 (en) | 2017-06-27 | 2020-12-08 | Ethicon Llc | Surgical anvil arrangements |
US10631859B2 (en) | 2017-06-27 | 2020-04-28 | Ethicon Llc | Articulation systems for surgical instruments |
US11090049B2 (en) | 2017-06-27 | 2021-08-17 | Cilag Gmbh International | Staple forming pocket arrangements |
US11266405B2 (en) | 2017-06-27 | 2022-03-08 | Cilag Gmbh International | Surgical anvil manufacturing methods |
US11141154B2 (en) | 2017-06-27 | 2021-10-12 | Cilag Gmbh International | Surgical end effectors and anvils |
US11324503B2 (en) | 2017-06-27 | 2022-05-10 | Cilag Gmbh International | Surgical firing member arrangements |
US10765427B2 (en) | 2017-06-28 | 2020-09-08 | Ethicon Llc | Method for articulating a surgical instrument |
US11642128B2 (en) | 2017-06-28 | 2023-05-09 | Cilag Gmbh International | Method for articulating a surgical instrument |
USD854151S1 (en) | 2017-06-28 | 2019-07-16 | Ethicon Llc | Surgical instrument shaft |
US11696759B2 (en) | 2017-06-28 | 2023-07-11 | Cilag Gmbh International | Surgical stapling instruments comprising shortened staple cartridge noses |
US10903685B2 (en) | 2017-06-28 | 2021-01-26 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies forming capacitive channels |
US11389161B2 (en) | 2017-06-28 | 2022-07-19 | Cilag Gmbh International | Surgical instrument comprising selectively actuatable rotatable couplers |
USD906355S1 (en) | 2017-06-28 | 2020-12-29 | Ethicon Llc | Display screen or portion thereof with a graphical user interface for a surgical instrument |
US11678880B2 (en) | 2017-06-28 | 2023-06-20 | Cilag Gmbh International | Surgical instrument comprising a shaft including a housing arrangement |
USD851762S1 (en) | 2017-06-28 | 2019-06-18 | Ethicon Llc | Anvil |
US11058424B2 (en) | 2017-06-28 | 2021-07-13 | Cilag Gmbh International | Surgical instrument comprising an offset articulation joint |
US10716614B2 (en) | 2017-06-28 | 2020-07-21 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies with increased contact pressure |
US10695057B2 (en) | 2017-06-28 | 2020-06-30 | Ethicon Llc | Surgical instrument lockout arrangement |
US10588633B2 (en) | 2017-06-28 | 2020-03-17 | Ethicon Llc | Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing |
USD869655S1 (en) | 2017-06-28 | 2019-12-10 | Ethicon Llc | Surgical fastener cartridge |
US10758232B2 (en) | 2017-06-28 | 2020-09-01 | Ethicon Llc | Surgical instrument with positive jaw opening features |
US11478242B2 (en) | 2017-06-28 | 2022-10-25 | Cilag Gmbh International | Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw |
US11000279B2 (en) | 2017-06-28 | 2021-05-11 | Ethicon Llc | Surgical instrument comprising an articulation system ratio |
US10211586B2 (en) | 2017-06-28 | 2019-02-19 | Ethicon Llc | Surgical shaft assemblies with watertight housings |
USD1018577S1 (en) | 2017-06-28 | 2024-03-19 | Cilag Gmbh International | Display screen or portion thereof with a graphical user interface for a surgical instrument |
US11020114B2 (en) | 2017-06-28 | 2021-06-01 | Cilag Gmbh International | Surgical instruments with articulatable end effector with axially shortened articulation joint configurations |
US11564686B2 (en) | 2017-06-28 | 2023-01-31 | Cilag Gmbh International | Surgical shaft assemblies with flexible interfaces |
US10639037B2 (en) | 2017-06-28 | 2020-05-05 | Ethicon Llc | Surgical instrument with axially movable closure member |
US11529140B2 (en) | 2017-06-28 | 2022-12-20 | Cilag Gmbh International | Surgical instrument lockout arrangement |
US10786253B2 (en) | 2017-06-28 | 2020-09-29 | Ethicon Llc | Surgical end effectors with improved jaw aperture arrangements |
US11246592B2 (en) | 2017-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical instrument comprising an articulation system lockable to a frame |
US11826048B2 (en) | 2017-06-28 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising selectively actuatable rotatable couplers |
US11259805B2 (en) | 2017-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical instrument comprising firing member supports |
US11083455B2 (en) | 2017-06-28 | 2021-08-10 | Cilag Gmbh International | Surgical instrument comprising an articulation system ratio |
US11484310B2 (en) | 2017-06-28 | 2022-11-01 | Cilag Gmbh International | Surgical instrument comprising a shaft including a closure tube profile |
US10779824B2 (en) | 2017-06-28 | 2020-09-22 | Ethicon Llc | Surgical instrument comprising an articulation system lockable by a closure system |
US10932772B2 (en) | 2017-06-29 | 2021-03-02 | Ethicon Llc | Methods for closed loop velocity control for robotic surgical instrument |
US10258418B2 (en) | 2017-06-29 | 2019-04-16 | Ethicon Llc | System for controlling articulation forces |
US10398434B2 (en) | 2017-06-29 | 2019-09-03 | Ethicon Llc | Closed loop velocity control of closure member for robotic surgical instrument |
US11890005B2 (en) | 2017-06-29 | 2024-02-06 | Cilag Gmbh International | Methods for closed loop velocity control for robotic surgical instrument |
US11007022B2 (en) | 2017-06-29 | 2021-05-18 | Ethicon Llc | Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument |
US10898183B2 (en) | 2017-06-29 | 2021-01-26 | Ethicon Llc | Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing |
US11471155B2 (en) | 2017-08-03 | 2022-10-18 | Cilag Gmbh International | Surgical system bailout |
US11304695B2 (en) | 2017-08-03 | 2022-04-19 | Cilag Gmbh International | Surgical system shaft interconnection |
US11944300B2 (en) | 2017-08-03 | 2024-04-02 | Cilag Gmbh International | Method for operating a surgical system bailout |
US10765429B2 (en) | 2017-09-29 | 2020-09-08 | Ethicon Llc | Systems and methods for providing alerts according to the operational state of a surgical instrument |
US10743872B2 (en) | 2017-09-29 | 2020-08-18 | Ethicon Llc | System and methods for controlling a display of a surgical instrument |
USD907647S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
USD917500S1 (en) | 2017-09-29 | 2021-04-27 | Ethicon Llc | Display screen or portion thereof with graphical user interface |
USD907648S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
US10729501B2 (en) | 2017-09-29 | 2020-08-04 | Ethicon Llc | Systems and methods for language selection of a surgical instrument |
US11399829B2 (en) | 2017-09-29 | 2022-08-02 | Cilag Gmbh International | Systems and methods of initiating a power shutdown mode for a surgical instrument |
US10796471B2 (en) | 2017-09-29 | 2020-10-06 | Ethicon Llc | Systems and methods of displaying a knife position for a surgical instrument |
US11090075B2 (en) | 2017-10-30 | 2021-08-17 | Cilag Gmbh International | Articulation features for surgical end effector |
US11134944B2 (en) | 2017-10-30 | 2021-10-05 | Cilag Gmbh International | Surgical stapler knife motion controls |
US10842490B2 (en) | 2017-10-31 | 2020-11-24 | Ethicon Llc | Cartridge body design with force reduction based on firing completion |
US11478244B2 (en) | 2017-10-31 | 2022-10-25 | Cilag Gmbh International | Cartridge body design with force reduction based on firing completion |
US10779903B2 (en) | 2017-10-31 | 2020-09-22 | Ethicon Llc | Positive shaft rotation lock activated by jaw closure |
US10743875B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member |
US10687813B2 (en) | 2017-12-15 | 2020-06-23 | Ethicon Llc | Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments |
US11071543B2 (en) | 2017-12-15 | 2021-07-27 | Cilag Gmbh International | Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges |
US10869666B2 (en) | 2017-12-15 | 2020-12-22 | Ethicon Llc | Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument |
US11197670B2 (en) | 2017-12-15 | 2021-12-14 | Cilag Gmbh International | Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed |
US10779825B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments |
US11896222B2 (en) | 2017-12-15 | 2024-02-13 | Cilag Gmbh International | Methods of operating surgical end effectors |
US10779826B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Methods of operating surgical end effectors |
US11033267B2 (en) | 2017-12-15 | 2021-06-15 | Ethicon Llc | Systems and methods of controlling a clamping member firing rate of a surgical instrument |
US10743874B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Sealed adapters for use with electromechanical surgical instruments |
US11006955B2 (en) | 2017-12-15 | 2021-05-18 | Ethicon Llc | End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments |
US10828033B2 (en) | 2017-12-15 | 2020-11-10 | Ethicon Llc | Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto |
US10966718B2 (en) | 2017-12-15 | 2021-04-06 | Ethicon Llc | Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments |
US11020112B2 (en) | 2017-12-19 | 2021-06-01 | Ethicon Llc | Surgical tools configured for interchangeable use with different controller interfaces |
USD910847S1 (en) | 2017-12-19 | 2021-02-16 | Ethicon Llc | Surgical instrument assembly |
US11284953B2 (en) | 2017-12-19 | 2022-03-29 | Cilag Gmbh International | Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly |
US11045270B2 (en) | 2017-12-19 | 2021-06-29 | Cilag Gmbh International | Robotic attachment comprising exterior drive actuator |
US10729509B2 (en) | 2017-12-19 | 2020-08-04 | Ethicon Llc | Surgical instrument comprising closure and firing locking mechanism |
US10716565B2 (en) | 2017-12-19 | 2020-07-21 | Ethicon Llc | Surgical instruments with dual articulation drivers |
US10835330B2 (en) | 2017-12-19 | 2020-11-17 | Ethicon Llc | Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly |
US11369368B2 (en) | 2017-12-21 | 2022-06-28 | Cilag Gmbh International | Surgical instrument comprising synchronized drive systems |
US11849939B2 (en) | 2017-12-21 | 2023-12-26 | Cilag Gmbh International | Continuous use self-propelled stapling instrument |
US11311290B2 (en) | 2017-12-21 | 2022-04-26 | Cilag Gmbh International | Surgical instrument comprising an end effector dampener |
US11129680B2 (en) | 2017-12-21 | 2021-09-28 | Cilag Gmbh International | Surgical instrument comprising a projector |
US10682134B2 (en) | 2017-12-21 | 2020-06-16 | Ethicon Llc | Continuous use self-propelled stapling instrument |
US11583274B2 (en) | 2017-12-21 | 2023-02-21 | Cilag Gmbh International | Self-guiding stapling instrument |
US11337691B2 (en) | 2017-12-21 | 2022-05-24 | Cilag Gmbh International | Surgical instrument configured to determine firing path |
US11576668B2 (en) | 2017-12-21 | 2023-02-14 | Cilag Gmbh International | Staple instrument comprising a firing path display |
US10743868B2 (en) | 2017-12-21 | 2020-08-18 | Ethicon Llc | Surgical instrument comprising a pivotable distal head |
US11179151B2 (en) | 2017-12-21 | 2021-11-23 | Cilag Gmbh International | Surgical instrument comprising a display |
US11364027B2 (en) | 2017-12-21 | 2022-06-21 | Cilag Gmbh International | Surgical instrument comprising speed control |
US11883019B2 (en) | 2017-12-21 | 2024-01-30 | Cilag Gmbh International | Stapling instrument comprising a staple feeding system |
US11179152B2 (en) | 2017-12-21 | 2021-11-23 | Cilag Gmbh International | Surgical instrument comprising a tissue grasping system |
US11076853B2 (en) | 2017-12-21 | 2021-08-03 | Cilag Gmbh International | Systems and methods of displaying a knife position during transection for a surgical instrument |
US11751867B2 (en) | 2017-12-21 | 2023-09-12 | Cilag Gmbh International | Surgical instrument comprising sequenced systems |
US10779821B2 (en) | 2018-08-20 | 2020-09-22 | Ethicon Llc | Surgical stapler anvils with tissue stop features configured to avoid tissue pinch |
US11253256B2 (en) | 2018-08-20 | 2022-02-22 | Cilag Gmbh International | Articulatable motor powered surgical instruments with dedicated articulation motor arrangements |
USD914878S1 (en) | 2018-08-20 | 2021-03-30 | Ethicon Llc | Surgical instrument anvil |
US10842492B2 (en) | 2018-08-20 | 2020-11-24 | Ethicon Llc | Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system |
US11291440B2 (en) | 2018-08-20 | 2022-04-05 | Cilag Gmbh International | Method for operating a powered articulatable surgical instrument |
US10912559B2 (en) | 2018-08-20 | 2021-02-09 | Ethicon Llc | Reinforced deformable anvil tip for surgical stapler anvil |
US11045192B2 (en) | 2018-08-20 | 2021-06-29 | Cilag Gmbh International | Fabricating techniques for surgical stapler anvils |
US10856870B2 (en) | 2018-08-20 | 2020-12-08 | Ethicon Llc | Switching arrangements for motor powered articulatable surgical instruments |
US11039834B2 (en) | 2018-08-20 | 2021-06-22 | Cilag Gmbh International | Surgical stapler anvils with staple directing protrusions and tissue stability features |
US11083458B2 (en) | 2018-08-20 | 2021-08-10 | Cilag Gmbh International | Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions |
US11207065B2 (en) | 2018-08-20 | 2021-12-28 | Cilag Gmbh International | Method for fabricating surgical stapler anvils |
US11324501B2 (en) | 2018-08-20 | 2022-05-10 | Cilag Gmbh International | Surgical stapling devices with improved closure members |
US11172929B2 (en) | 2019-03-25 | 2021-11-16 | Cilag Gmbh International | Articulation drive arrangements for surgical systems |
US11147553B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11696761B2 (en) | 2019-03-25 | 2023-07-11 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11147551B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
US11471157B2 (en) | 2019-04-30 | 2022-10-18 | Cilag Gmbh International | Articulation control mapping for a surgical instrument |
US11426251B2 (en) | 2019-04-30 | 2022-08-30 | Cilag Gmbh International | Articulation directional lights on a surgical instrument |
US11432816B2 (en) | 2019-04-30 | 2022-09-06 | Cilag Gmbh International | Articulation pin for a surgical instrument |
US11648009B2 (en) | 2019-04-30 | 2023-05-16 | Cilag Gmbh International | Rotatable jaw tip for a surgical instrument |
US11253254B2 (en) | 2019-04-30 | 2022-02-22 | Cilag Gmbh International | Shaft rotation actuator on a surgical instrument |
US11903581B2 (en) | 2019-04-30 | 2024-02-20 | Cilag Gmbh International | Methods for stapling tissue using a surgical instrument |
US11452528B2 (en) | 2019-04-30 | 2022-09-27 | Cilag Gmbh International | Articulation actuators for a surgical instrument |
US11012599B2 (en) | 2019-06-20 | 2021-05-18 | Ethicon Llc | Hyperspectral imaging in a light deficient environment |
WO2020256918A1 (en) * | 2019-06-20 | 2020-12-24 | Ethicon Llc | Fluorescence imaging in a light deficient environment |
US11758256B2 (en) | 2019-06-20 | 2023-09-12 | Cilag Gmbh International | Fluorescence imaging in a light deficient environment |
US11937784B2 (en) | 2019-06-20 | 2024-03-26 | Cilag Gmbh International | Fluorescence imaging in a light deficient environment |
US11533417B2 (en) | 2019-06-20 | 2022-12-20 | Cilag Gmbh International | Laser scanning and tool tracking imaging in a light deficient environment |
US11771419B2 (en) | 2019-06-28 | 2023-10-03 | Cilag Gmbh International | Packaging for a replaceable component of a surgical stapling system |
US11298127B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Interational | Surgical stapling system having a lockout mechanism for an incompatible cartridge |
US11298132B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Inlernational | Staple cartridge including a honeycomb extension |
US11627959B2 (en) | 2019-06-28 | 2023-04-18 | Cilag Gmbh International | Surgical instruments including manual and powered system lockouts |
US11350938B2 (en) | 2019-06-28 | 2022-06-07 | Cilag Gmbh International | Surgical instrument comprising an aligned rfid sensor |
US11497492B2 (en) | 2019-06-28 | 2022-11-15 | Cilag Gmbh International | Surgical instrument including an articulation lock |
US11291451B2 (en) | 2019-06-28 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with battery compatibility verification functionality |
US11638587B2 (en) | 2019-06-28 | 2023-05-02 | Cilag Gmbh International | RFID identification systems for surgical instruments |
US11376098B2 (en) | 2019-06-28 | 2022-07-05 | Cilag Gmbh International | Surgical instrument system comprising an RFID system |
US11259803B2 (en) | 2019-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical stapling system having an information encryption protocol |
US11553919B2 (en) | 2019-06-28 | 2023-01-17 | Cilag Gmbh International | Method for authenticating the compatibility of a staple cartridge with a surgical instrument |
US11399837B2 (en) | 2019-06-28 | 2022-08-02 | Cilag Gmbh International | Mechanisms for motor control adjustments of a motorized surgical instrument |
US11553971B2 (en) | 2019-06-28 | 2023-01-17 | Cilag Gmbh International | Surgical RFID assemblies for display and communication |
US11246678B2 (en) | 2019-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical stapling system having a frangible RFID tag |
US11744593B2 (en) | 2019-06-28 | 2023-09-05 | Cilag Gmbh International | Method for authenticating the compatibility of a staple cartridge with a surgical instrument |
US11241235B2 (en) | 2019-06-28 | 2022-02-08 | Cilag Gmbh International | Method of using multiple RFID chips with a surgical assembly |
US11426167B2 (en) | 2019-06-28 | 2022-08-30 | Cilag Gmbh International | Mechanisms for proper anvil attachment surgical stapling head assembly |
US11229437B2 (en) | 2019-06-28 | 2022-01-25 | Cilag Gmbh International | Method for authenticating the compatibility of a staple cartridge with a surgical instrument |
US11660163B2 (en) | 2019-06-28 | 2023-05-30 | Cilag Gmbh International | Surgical system with RFID tags for updating motor assembly parameters |
US11051807B2 (en) | 2019-06-28 | 2021-07-06 | Cilag Gmbh International | Packaging assembly including a particulate trap |
US11224497B2 (en) | 2019-06-28 | 2022-01-18 | Cilag Gmbh International | Surgical systems with multiple RFID tags |
US11464601B2 (en) | 2019-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument comprising an RFID system for tracking a movable component |
US11523822B2 (en) | 2019-06-28 | 2022-12-13 | Cilag Gmbh International | Battery pack including a circuit interrupter |
US11219455B2 (en) | 2019-06-28 | 2022-01-11 | Cilag Gmbh International | Surgical instrument including a lockout key |
US11684434B2 (en) | 2019-06-28 | 2023-06-27 | Cilag Gmbh International | Surgical RFID assemblies for instrument operational setting control |
US11684369B2 (en) | 2019-06-28 | 2023-06-27 | Cilag Gmbh International | Method of using multiple RFID chips with a surgical assembly |
US11478241B2 (en) | 2019-06-28 | 2022-10-25 | Cilag Gmbh International | Staple cartridge including projections |
US11911032B2 (en) | 2019-12-19 | 2024-02-27 | Cilag Gmbh International | Staple cartridge comprising a seating cam |
US11559304B2 (en) | 2019-12-19 | 2023-01-24 | Cilag Gmbh International | Surgical instrument comprising a rapid closure mechanism |
US11304696B2 (en) | 2019-12-19 | 2022-04-19 | Cilag Gmbh International | Surgical instrument comprising a powered articulation system |
US11844520B2 (en) | 2019-12-19 | 2023-12-19 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11607219B2 (en) | 2019-12-19 | 2023-03-21 | Cilag Gmbh International | Staple cartridge comprising a detachable tissue cutting knife |
US11701111B2 (en) | 2019-12-19 | 2023-07-18 | Cilag Gmbh International | Method for operating a surgical stapling instrument |
US11576672B2 (en) | 2019-12-19 | 2023-02-14 | Cilag Gmbh International | Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw |
US11234698B2 (en) | 2019-12-19 | 2022-02-01 | Cilag Gmbh International | Stapling system comprising a clamp lockout and a firing lockout |
US11291447B2 (en) | 2019-12-19 | 2022-04-05 | Cilag Gmbh International | Stapling instrument comprising independent jaw closing and staple firing systems |
US11529139B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Motor driven surgical instrument |
US11931033B2 (en) | 2019-12-19 | 2024-03-19 | Cilag Gmbh International | Staple cartridge comprising a latch lockout |
US11529137B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
US11464512B2 (en) | 2019-12-19 | 2022-10-11 | Cilag Gmbh International | Staple cartridge comprising a curved deck surface |
US11504122B2 (en) | 2019-12-19 | 2022-11-22 | Cilag Gmbh International | Surgical instrument comprising a nested firing member |
US11446029B2 (en) | 2019-12-19 | 2022-09-20 | Cilag Gmbh International | Staple cartridge comprising projections extending from a curved deck surface |
USD975851S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD975278S1 (en) | 2020-06-02 | 2023-01-10 | Cilag Gmbh International | Staple cartridge |
USD974560S1 (en) | 2020-06-02 | 2023-01-03 | Cilag Gmbh International | Staple cartridge |
USD975850S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
USD966512S1 (en) | 2020-06-02 | 2022-10-11 | Cilag Gmbh International | Staple cartridge |
USD967421S1 (en) | 2020-06-02 | 2022-10-18 | Cilag Gmbh International | Staple cartridge |
USD976401S1 (en) | 2020-06-02 | 2023-01-24 | Cilag Gmbh International | Staple cartridge |
US11864756B2 (en) | 2020-07-28 | 2024-01-09 | Cilag Gmbh International | Surgical instruments with flexible ball chain drive arrangements |
US11660090B2 (en) | 2020-07-28 | 2023-05-30 | Cllag GmbH International | Surgical instruments with segmented flexible drive arrangements |
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US11826013B2 (en) | 2020-07-28 | 2023-11-28 | Cilag Gmbh International | Surgical instruments with firing member closure features |
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US11857182B2 (en) | 2020-07-28 | 2024-01-02 | Cilag Gmbh International | Surgical instruments with combination function articulation joint arrangements |
US11617577B2 (en) | 2020-10-29 | 2023-04-04 | Cilag Gmbh International | Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable |
US11452526B2 (en) | 2020-10-29 | 2022-09-27 | Cilag Gmbh International | Surgical instrument comprising a staged voltage regulation start-up system |
USD1013170S1 (en) | 2020-10-29 | 2024-01-30 | Cilag Gmbh International | Surgical instrument assembly |
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US11779330B2 (en) | 2020-10-29 | 2023-10-10 | Cilag Gmbh International | Surgical instrument comprising a jaw alignment system |
US11534259B2 (en) | 2020-10-29 | 2022-12-27 | Cilag Gmbh International | Surgical instrument comprising an articulation indicator |
US11931025B2 (en) | 2020-10-29 | 2024-03-19 | Cilag Gmbh International | Surgical instrument comprising a releasable closure drive lock |
US11717289B2 (en) | 2020-10-29 | 2023-08-08 | Cilag Gmbh International | Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable |
USD980425S1 (en) | 2020-10-29 | 2023-03-07 | Cilag Gmbh International | Surgical instrument assembly |
US11517390B2 (en) | 2020-10-29 | 2022-12-06 | Cilag Gmbh International | Surgical instrument comprising a limited travel switch |
US11844518B2 (en) | 2020-10-29 | 2023-12-19 | Cilag Gmbh International | Method for operating a surgical instrument |
US11737751B2 (en) | 2020-12-02 | 2023-08-29 | Cilag Gmbh International | Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings |
US11678882B2 (en) | 2020-12-02 | 2023-06-20 | Cilag Gmbh International | Surgical instruments with interactive features to remedy incidental sled movements |
US11653915B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Surgical instruments with sled location detection and adjustment features |
US11849943B2 (en) | 2020-12-02 | 2023-12-26 | Cilag Gmbh International | Surgical instrument with cartridge release mechanisms |
US11944296B2 (en) | 2020-12-02 | 2024-04-02 | Cilag Gmbh International | Powered surgical instruments with external connectors |
US11653920B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Powered surgical instruments with communication interfaces through sterile barrier |
US11627960B2 (en) | 2020-12-02 | 2023-04-18 | Cilag Gmbh International | Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections |
US11890010B2 (en) | 2020-12-02 | 2024-02-06 | Cllag GmbH International | Dual-sided reinforced reload for surgical instruments |
US11744581B2 (en) | 2020-12-02 | 2023-09-05 | Cilag Gmbh International | Powered surgical instruments with multi-phase tissue treatment |
US11812964B2 (en) | 2021-02-26 | 2023-11-14 | Cilag Gmbh International | Staple cartridge comprising a power management circuit |
US11701113B2 (en) | 2021-02-26 | 2023-07-18 | Cilag Gmbh International | Stapling instrument comprising a separate power antenna and a data transfer antenna |
US11793514B2 (en) | 2021-02-26 | 2023-10-24 | Cilag Gmbh International | Staple cartridge comprising sensor array which may be embedded in cartridge body |
US11723657B2 (en) | 2021-02-26 | 2023-08-15 | Cilag Gmbh International | Adjustable communication based on available bandwidth and power capacity |
US11730473B2 (en) | 2021-02-26 | 2023-08-22 | Cilag Gmbh International | Monitoring of manufacturing life-cycle |
US11696757B2 (en) | 2021-02-26 | 2023-07-11 | Cilag Gmbh International | Monitoring of internal systems to detect and track cartridge motion status |
US11950779B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Method of powering and communicating with a staple cartridge |
US11751869B2 (en) | 2021-02-26 | 2023-09-12 | Cilag Gmbh International | Monitoring of multiple sensors over time to detect moving characteristics of tissue |
US11749877B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Stapling instrument comprising a signal antenna |
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US11723658B2 (en) | 2021-03-22 | 2023-08-15 | Cilag Gmbh International | Staple cartridge comprising a firing lockout |
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US11806011B2 (en) | 2021-03-22 | 2023-11-07 | Cilag Gmbh International | Stapling instrument comprising tissue compression systems |
US11826042B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising a firing drive including a selectable leverage mechanism |
US11826012B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising a pulsed motor-driven firing rack |
US11717291B2 (en) | 2021-03-22 | 2023-08-08 | Cilag Gmbh International | Staple cartridge comprising staples configured to apply different tissue compression |
US11737749B2 (en) | 2021-03-22 | 2023-08-29 | Cilag Gmbh International | Surgical stapling instrument comprising a retraction system |
US11849944B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Drivers for fastener cartridge assemblies having rotary drive screws |
US11832816B2 (en) | 2021-03-24 | 2023-12-05 | Cilag Gmbh International | Surgical stapling assembly comprising nonplanar staples and planar staples |
US11896218B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Method of using a powered stapling device |
US11786243B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Firing members having flexible portions for adapting to a load during a surgical firing stroke |
US11857183B2 (en) | 2021-03-24 | 2024-01-02 | Cilag Gmbh International | Stapling assembly components having metal substrates and plastic bodies |
US11786239B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Surgical instrument articulation joint arrangements comprising multiple moving linkage features |
US11849945B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Rotary-driven surgical stapling assembly comprising eccentrically driven firing member |
US11944336B2 (en) | 2021-03-24 | 2024-04-02 | Cilag Gmbh International | Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments |
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US11793516B2 (en) | 2021-03-24 | 2023-10-24 | Cilag Gmbh International | Surgical staple cartridge comprising longitudinal support beam |
US11896219B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Mating features between drivers and underside of a cartridge deck |
US11903582B2 (en) | 2021-03-24 | 2024-02-20 | Cilag Gmbh International | Leveraging surfaces for cartridge installation |
US11723662B2 (en) | 2021-05-28 | 2023-08-15 | Cilag Gmbh International | Stapling instrument comprising an articulation control display |
US11826047B2 (en) | 2021-05-28 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising jaw mounts |
US11918217B2 (en) | 2021-05-28 | 2024-03-05 | Cilag Gmbh International | Stapling instrument comprising a staple cartridge insertion stop |
US11957344B2 (en) | 2021-09-27 | 2024-04-16 | Cilag Gmbh International | Surgical stapler having rows of obliquely oriented staples |
US11877745B2 (en) | 2021-10-18 | 2024-01-23 | Cilag Gmbh International | Surgical stapling assembly having longitudinally-repeating staple leg clusters |
US11957337B2 (en) | 2021-10-18 | 2024-04-16 | Cilag Gmbh International | Surgical stapling assembly with offset ramped drive surfaces |
US11937816B2 (en) | 2021-10-28 | 2024-03-26 | Cilag Gmbh International | Electrical lead arrangements for surgical instruments |
US11957339B2 (en) | 2021-11-09 | 2024-04-16 | Cilag Gmbh International | Method for fabricating surgical stapler anvils |
US11957795B2 (en) | 2021-12-13 | 2024-04-16 | Cilag Gmbh International | Tissue thickness compensator configured to redistribute compressive forces |
US11957345B2 (en) | 2022-12-19 | 2024-04-16 | Cilag Gmbh International | Articulatable surgical instruments with conductive pathways for signal communication |
Also Published As
Publication number | Publication date |
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EP2604216B1 (en) | 2018-08-22 |
US10342618B2 (en) | 2019-07-09 |
US20140155876A1 (en) | 2014-06-05 |
US20140171929A1 (en) | 2014-06-19 |
EP2604216A1 (en) | 2013-06-19 |
US10342617B2 (en) | 2019-07-09 |
EP2604215B1 (en) | 2017-10-11 |
EP2604215A1 (en) | 2013-06-19 |
JP2010046518A (en) | 2010-03-04 |
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