US20080097583A1 - Stent with flexible hinges - Google Patents
Stent with flexible hinges Download PDFInfo
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- US20080097583A1 US20080097583A1 US11/582,795 US58279506A US2008097583A1 US 20080097583 A1 US20080097583 A1 US 20080097583A1 US 58279506 A US58279506 A US 58279506A US 2008097583 A1 US2008097583 A1 US 2008097583A1
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- stent
- struts
- set forth
- expandable stent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
Description
- The present application relates to expandable stents and, more particularly, to expandable stents with flexible hinges.
- It is desirable to provide flexibility in stents to facilitate introduction of the stent into vessels that are difficult to reach. Often, however, characteristics of the stent that provide longitudinal flexibility that is desirable when introducing the stent into the vessel can be disadvantageous in terms of keeping the stent in an expanded condition. For example, stents formed from interconnected rings with closed cell structures or generally diamond-shaped cells are typically less flexible than stents formed from one or more helices, but are usually more uniformly and consistently expandable than helical stents. It is desirable to provide a stent with substantial flexibility that is adapted to be expanded in a uniform and consistent fashion.
- In WO 03/015664, which is incorporated by reference, a stent having interconnected struts with openings for drug delivery is disclosed. However, elements for bridging the struts are generally thinner and spaced further apart than the struts. Thus, for such drug-eluting stents, the bridging element can provide an area of reduced or less consistent drug delivery. It is desirable to provide a drug-eluting stent in which areas of reduced or less consistent drug delivery can be reduced.
- In accordance with an aspect of the present invention, a helical stent comprises at least one helical winding, each helical winding comprising a plurality of alternating long struts and short struts, ends of at least some of the long struts being joined to an end of an adjacent short strut by a flexible hinge arrangement, the struts being substantially rigid, and at least one interconnection member connecting a hinge arrangement on one turn of the at least one winding with a hinge arrangement on an adjacent turn of the at least one winding, wherein fewer than all hinge arrangements on the at least one helical winding are connected to other hinge arrangements by an interconnection member.
- In accordance with another aspect of the present invention, a helical stent comprises at least one helical winding, each helical winding comprising a plurality of struts, ends of the struts being joined to an end of an adjacent strut by a flexible hinge arrangement, the struts being substantially rigid, and at least one interconnection member connecting a hinge arrangement on one turn of the at least one winding with a hinge arrangement on an adjacent turn of the at least one winding, wherein fewer than all hinge arrangements on the at least one helical winding are connected to other hinge arrangements by an interconnection member.
- In accordance with another aspect of the present invention, a helical stent comprises at least one helical winding, each helical winding comprising a plurality of pairs of long struts and short struts, the struts being substantially rigid, and a plurality of flexible hinge arrangements, ends of at least some of the long struts being joined to an end of an adjacent short strut by the hinge arrangements, each of the plurality of flexible hinge arrangements comprising a substantially rigid connecting member and a first flexible hinge between the connecting member and a long strut and a second flexible hinge between the connecting member and a short strut.
- In accordance with another aspect of the present invention, a helical stent comprises at least one helical winding, each helical winding comprising a plurality of pairs of long strut assemblies and short strut assemblies, the struts being substantially rigid, the long strut assembly comprising at least two struts and being longer than the short strut assembly, and a plurality of flexible hinge arrangements, ends of at least some of the long strut assemblies being joined to an end of an adjacent short strut assembly by the hinge arrangements, each of the plurality of flexible hinge arrangements comprising a substantially rigid connecting member and a first flexible hinge between the connecting member and a long strut assembly and a second flexible hinge between the connecting member and a short strut assembly.
- In accordance with another aspect of the present invention, an expandable stent includes a plurality of expandable cells having at least eight sides and formed by a plurality of alternating long and short, substantially non-deforming struts interconnected by deformable hinges.
- In accordance with a further aspect of the present invention, an expandable stent includes a plurality of struts extending substantially longitudinally along an axis of the stent in an unexpanded configuration and a plurality of hinges interconnecting the struts. The plurality of hinges each have a straight active portion which extends substantially circumferentially around the stent in the unexpanded configuration and two curved portions interconnecting the active portion to adjacent ones of the plurality of struts.
- In accordance with another further aspect of the present invention, an expandable stent includes a plurality of struts extending substantially longitudinally along an axis of the stent in an unexpanded configuration and a plurality of hinge arrangements interconnecting the struts. Each of the hinge arrangements includes a central portion and four tapered hinges each connected at one end to the central portion and at another end to one of the plurality of struts. Each of the tapered hinges has a smallest width closer to the struts and a largest width closer to the central portion.
- In accordance with another aspect of the present invention, an expandable stent includes a plurality of struts extending substantially longitudinally along an axis of the stent in an unexpanded configuration, a plurality of first hinges interconnecting the struts, and a plurality of interconnecting hinge arrangements interconnecting the struts. The plurality of hinges each have a straight active portion which extends substantially circumferentially around the stent in the unexpanded configuration interconnected to adjacent ones of the plurality of struts. Each of the interconnecting hinge arrangements includes a central portion and four second hinges each connected at one end to the central portion and at another end to one of the plurality of struts.
- The features and advantages of the present invention are well understood by reading the following detailed description in conjunction with the drawings in which like numerals indicate similar elements and in which:
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FIG. 1 is a view of a stent according to an embodiment of the present invention shown in partly expanded form, cut along a line parallel to a longitudinal axis of the stent, and unrolled; -
FIGS. 2A and 2B are views of a stent according to another embodiment of the present invention shown in unexpanded and expanded form, cut along a line parallel to a longitudinal axis of the stent, and unrolled; -
FIG. 3 is a view of a stent according to another embodiment of the present invention shown in partly expanded form, cut along a line parallel to a longitudinal axis of the stent, and unrolled; -
FIGS. 4A and 4B are views of a portion of a stent according to an embodiment of the present invention shown in unexpanded and expanded form; -
FIG. 5 is a schematic view of a portion of an end ring for a stent according to an embodiment of the present invention; -
FIG. 6 is a schematic view of a portion of a helical winding according to another embodiment of the present invention; -
FIG. 7 is a view of a stent according to yet another embodiment of the present invention shown in partly expanded form, cut along a line parallel to a longitudinal axis of the stent, and unrolled. -
FIG. 8 is an enlarged view of one of the hinge arrangements fromFIG. 7 ; and -
FIG. 9 is an enlarged view of one of the interconnection hinge arrangements fromFIG. 7 . - A
helical stent 21 according to an embodiment of the present invention is shown inFIG. 1 . Thestent 21 is shown inFIG. 1 as it would appear if the stent were in an at least partially expanded condition and cut along its length. More particularly, thestent 21 shown inFIG. 1 is shown in the form in which it would appear if it were cut along its length and the cut article was laid out flat. Thestent 21 can be formed in any suitable manner, such as by being laser cut from a tube made of a suitable material including cobalt chromium alloys, stainless steel alloys or nickel titanium alloys. In an “as cut” version of thestent 21, top andbottom edges FIGS. 2A and 2B show another embodiment of astent 121 in an unexpanded and an at least partially expanded condition, respectively, and cut along its length. The present invention will be described as a vascular stent, such as a coronary or peripheral stent. However, the stent structure described can also take the form of other known stents. In practice, while a laser cut tubular coronary stent might have a diameter of approximately 2 mm when it is cut from a metal tube, it is ordinarily subsequently crimped to a more compressed condition (such as is shown inFIG. 2A ), to, for example, a diameter of approximately 1 mm and, upon expansion, such as by a balloon catheter, the expanded stent might have a diameter of approximately 2-4 mm, i.e., the components of the “expanded” stent would be more expanded than they appear in the illustrated “as cut” version. Other types of stents would have other diameters corresponding to their application. - The
stent 21 includes at least onehelical winding 27. Thestent 21 inFIG. 1 includes onehelical winding 27. Thestent 121 shown inFIG. 2B and the stent 221 shown inFIG. 3 each include twohelical windings 127′ and 127″, and 227′ and 227″, respectively. If desired, the stent can have more than two helical windings. Ordinarily, eachhelical winding 27 will have multiple winding turns, usually at least three turns. - As seen, for example, in
FIG. 1 , eachhelical winding 27 comprises a plurality of alternatinglong struts 29 andshort struts 31. Ends 33 of at least some of thelong struts 29 are joined to anend 35 of an adjacentshort strut 31 by aflexible hinge arrangement 37. Thestruts hinge arrangement 37 and ordinarily do not substantially bend or deform during expansion of thestent 21 from an unexpanded condition to an expanded condition. Thehinge arrangements 37 account for substantially all deformation or bending of components of thestent 21. During expansion of the stent from an unexpanded condition to an open or expanded condition, substantially all deformation occurs in the hinge arrangements, which are designed to facilitate uniform and consistent expansion of the stent, and which can facilitate retaining the stent in an expanded condition. Stents with ductile hinges connecting more rigid components such as struts are disclosed in U.S. Pat. No. 6,241,762, which is incorporated by reference. - Periodically, the alternating pattern of long and
short struts interconnection hinge arrangement 39. Theinterconnection hinge arrangement 39 connects oneturn 41 a of the at least one winding 27 with anadjacent turn 41 b of the at least one winding. Fewer than all bends of the winding 27 are connected to other bends by aninterconnection hinge arrangement 39. Theinterconnection hinge arrangements 39 have a rigid central portion and four deformable hinge portions connecting to four adjacent struts (two short and two long struts). - Ordinarily, a plurality of
interconnection hinge arrangements 39, i.e., at least two, are provided. Eachinterconnection hinge arrangement 39 replaces thehinge arrangement 37 on oneturn 41 a of the at least one winding 27 and the hinge arrangement on theadjacent turn 41 b of the at least one winding. In this way, two successive (in the direction of the helix)interconnection hinge arrangements 39 delimit acell 43 defined by long andshort struts arrangements 37 between the successive interconnection members. - Ordinarily, the long and
short struts FIG. 1 , thecell 43 can be multi-sided.FIG. 1 shows a cell with 16 sides (hexadecahedron) formed by 8 short and 8 long struts, however, cells with different numbers of sides can be provided (e.g., 4, 8, 12, 16, 20 . . . ). By linking only some of the bends withinterconnections 39 between adjacent turns 41a and 41 b of the helical winding 27, i.e., by providing fewer interconnections than pairs of hinge arrangements, thestent 21 can have substantial flexibility, while retaining even coverage upon expansion. - As seen in
FIGS. 4A and 4B , thehinge arrangement 37 can comprise afirst portion 45 connected to along strut 29 and asecond portion 47 connected to an adjacentshort strut 31. Thefirst portion 45 and thesecond portion 47 can have different cross-sectional shapes or other structural or other differences. For example, thesecond portion 47 of thehinge arrangement 37 can be provided with a smaller cross-sectional shape than thefirst portion 45 of the hinge arrangement, which can tend to make it easier to bend the second portion of the hinge arrangement. By providing an appropriate combination of characteristics for the first andsecond portions hinge assembly 37, characteristics of the stent during expansion from an unexpanded condition to an expanded condition can be controlled. For example, the stent shown inFIGS. 1 , 2A and 2B are approximately the same length in the unexpanded position as in the open position. In other words, the stent does not significantly shorten upon expansion. InFIG. 2A , it will be seen that the overall length of thestent 121 is largely a function of the lengths of thestruts FIG. 2A , it will be seen that the overall length of thestent 121 is largely a function of the lengths of thosesame struts struts -
FIGS. 4A and 4B show a single pair of adjacent long andshort struts FIG. 4B the long strut forms an angle of Θ1 with the longitudinal axis of the stent, it's length along the axis will be equal to Lcos (Θ1), which will be shorter than the length L. However, if the component of the short strut's 31 length along the longitudinal axis is shorter by the same amount, the helix will still advance a length “Z” for each zig-zag. This can be accomplished, for example, where theshort strut 31 forms a certain angle Θ2 with the longitudinal axis greater than the angle Θ1 formed by thelong strut 29. -
Cells 43 inFIG. 1 defined by connected long andshort struts - As seen in
FIG. 1 , thestent 21 can comprise first and second flexible end rings 49 and 51 hingedly joined to opposite ends 53 and 55, respectively, of the at least one helical winding 27. The end rings 49 and 51 can take a variety of suitable shapes. In the embodiment ofFIG. 1 , eachend ring ring halves ring hinge arrangements 60 and interconnectinghinge arrangements 61 that define alternating left- and right-pointing bends, which may be in the form of gentle, round curves, or sharper, more angular curves, in a zig-zag or accordion fashion. - If each left-pointing bend to left-pointing bend or right-pointing bend to right-pointing bend “wave” is considered as defining 360°, then the two
ring halves ring interconnection hinge arrangements 61 to define a plurality of diamond shapedend ring cells 63. Theinterconnection hinge arrangements 61 include a rigidcentral portion 65 and four hinges like theinterconnection hinge arrangements 39 and may be substantially identical to them. - In the embodiment of
FIG. 1 , all of the left-pointing bends of the first end ring halves 49 a and 51 a are joined to corresponding right-pointing bends of the second end ring halves 49 b and 51 b to form the closed diamond shapedcells 63. Although in this embodiment, the end ring struts 57 are substantially straight and thecells 63 are substantially diamond-shaped. However, other arrangements, including open cell configurations such as where every other pair of left-pointing bends are attached, can be provided. - The long and
short struts flexible hinge arrangements 37 of the at least one helical winding 27 typically also define alternating left-pointing bends P and right-pointing bends T.An end strut 67 at thefirst end 53 of the helical winding 27 can be disposed at a left-pointing bend and can be connected to an endring hinge arrangement 61 at a right-pointing bend of the firstend ring half 49 a of thefirst end ring 49. Similarly, anend strut 69 at thesecond end 55 of the helical winding 27 can be disposed at a right-pointing bend and can be connected to an endring hinge arrangement 61 at a left-pointing bend of the second end ring half 51 b of thesecond end ring 51. The end struts 67 and 69 at the first and second ends 53 and 55 of the helical winding 27 can be connected to the endring hinge arrangement 60 at the right-pointing bend of the firstend ring half 49 a of thefirst end ring 49 and at the left-pointing bend of the second end ring half 51 b of thesecond end ring 51, respectively, by a flexibleend hinge arrangement 71. This provides for freedom of motion of the end strut for expansion while maintaining even strut distribution on expansion. - For at least some of the alternating left-pointing bends and right-pointing bends of a helical winding 27, in a center portion of the stent, all the short struts are of the same length and all the long struts are of the same length. By contrast, in some parts of the helical winding such as the ends of the helical winding as seen at “A” in
FIG. 1 , the strut lengths are varied according to the available space and to achieve uniformity of strut coverage after expansion. Often, as seen inFIGS. 1 and 3 , but not always, several strut pairs in a row will have struts of the same length. - In addition to or instead of connecting the winding 27 to the end rings 49 and 51 by the
end hinge arrangements 71 at ends 53 and 55 of the winding, at least oneinterconnection hinge arrangement 73 can be used. As seen inFIG. 1 , the first right-pointing bend at which the flexibleend hinge arrangement 71 joins theend strut 67 of the winding 27 to thefirst end ring 49 and the second right-pointing bend at which theinterconnection hinge arrangement 73 joins the winding to the first end ring can be non-successive, which can enhance flexibility of thestent 21. Theinterconnections 73 typically include a rigid portion of four hinges like theinterconnections 39 and may be substantially identical to them. -
FIGS. 2A-2B andFIG. 3 show other forms of end-rings FIG. 1 . Referring toFIG. 2B , in the end rings 149 and 151, each end ring comprises a plurality of end ring struts 157 joined to each other at ends thereof by flexible endring hinge arrangements 161 that define alternating left-pointing bends and right-pointing bends. There are not two end ring halves, as in the embodiment ofFIG. 1 . The end rings 149, 151, 249, and 251 can otherwise be similar to the end rings 49 and 51, particularly in terms of how they are connected to the helical winding(s) of the stent. InFIGS. 2A-2B , the end ring struts 157 are shown as substantially straight struts such that, when the stent is in the expanded state (FIG. 2B ), the end ring struts 157 and hingearrangements 161 define a substantial Z-shape. As seen inFIG. 5 , if the end ring struts 557 are some other shape, such as curved or S-shaped, other shapes can be formed, such as substantial S-shapes, upon expansion of the stent. - The end-
rings FIG. 3 include a combination of diamond shaped portions and z-shaped portions. Additionally, while the end ring struts 57 in the embodiment ofFIG. 1 , as well as the end ring struts 157 inFIG. 2B , are all the same length, it is not necessary that they be the same length and, as seen inFIG. 3 , some end ring struts 257 a may be longer than other end ring struts 257 b. - Referring again to
FIG. 1 , while the helical winding 27 can have alternating long andshort struts additional struts 75 having lengths other than the lengths of the long and short struts, particularly in the area of the transition from the end rings 49 and 51 to the helical winding toward theends transitional struts 75 may be at theends - The helix is formed with an odd number of struts in each 360 degree turn of the helix which results in a configuration in which the
hinge arrangements 39 are lined up with hinge arrangements in adjacent turns. This is sometimes called an 180 degree out of phase construction. - Some or all of the
struts opening 77 for receiving a drug. WO 03/015664, which is incorporated by reference, describes a non-coated drug-eluting stent with openings for receiving a drug. In addition to havingopenings 77 in thestruts interconnection 39, in theend ring interconnection 65, in theend interconnection 73, in the hinge arrangement (see, for example,openings 77 in the rigid portions of the hinge assemblies 137 and 237 inFIGS. 2A-2B and 3). Although the examples of stents shown herein include openings for beneficial agents, these openings and the beneficial agents may be omitted. Where the openings are omitted, an agent may be incorporated into the stent in other ways, such as a coating or a polymer stent containing drug. - The
stent 21 can be configured with left-pointing bends and right-pointing bends of strut pairs ofstruts interconnection member 39 with adrug opening 77 may not be disposed between each left-pointing bend and right-pointing bend, drug delivery from openings on the stent will be substantially consistent, i.e., there are no particularly large spaces between drug openings. - The helical stent according to the present invention will ordinarily, as in the embodiment of
FIG. 1 , comprise a plurality of alternating long andshort struts helix 27 when disposed around a longitudinal axis. The helix may, however, be formed in other ways. For example, as seen inFIG. 6 , all of thestruts 629 forming the helix might be of the same length SL, while thehinge 637 might havelegs -
FIG. 3 shows an embodiment of a helical stent 221 comprising twohelical windings 227′ and 227″. Thehelical windings 227′ and 227″ comprise a plurality of pairs oflong struts 229 andshort struts 231 and a plurality offlexible hinge arrangements 261. In addition, thehelical windings 227′ and 227″ comprise anadditional strut 275 between two pairs of struts. Theadditional strut 275 is connected, via anadditional hinge arrangement 261′, at afirst end 275 a to anend 233 of along strut 229 of a first strut pair and is connected, via ahinge arrangement 261, at asecond end 275 b to an end 235 of ashort strut 231 of a second strut pair. Theadditional hinge arrangement 261′ may be of a type similar to thehinge arrangement 261. Thehinge arrangements FIG. 3 both comprise a substantially rigid connectingmember flexible hinge - With reference to
FIG. 3 , it is, of course, not necessary that thestruts 229 be longer than thestruts 231 and a helical winding can, instead, comprise a plurality of pairs of long strut assemblies and short strut assemblies. The long strut assembly can comprise at least twostruts strut 231 or multiple struts, like the long strut assembly. Thestruts -
FIG. 7 shows another embodiment of a stent 721 similar in many respects to the embodiment of thestent 21 shown inFIG. 1 . Differences between the stent 721 and thestent 21 include that the stent 721 can comprise hingearrangements 737 having a somewhat more recti-linear shape than thehinge arrangements 37 in thestent 21 inFIG. 1 which are curved or substantially semi-circular. In the stent 721,interconnection 739,end ring interconnection 765, andend interconnection 773 can be more compact to reduce spacing between windings than corresponding structures in thestent 21 ofFIG. 1 . Further, at least oneend ring interconnection 765′ can be elongated relative to other end ring elongatedmembers 765 and can extend around a greater portion of the circumference of the stent. Anend hinge arrangement 771 on the stent 721 can be longer and more curved, such as substantially S-shaped, than theend hinge arrangement 71 provided on thestent 21. On thestent 21, a majority of the long andshort struts drug receiving openings 77, respectively, a majority of the long andshort struts drug receiving openings 777, respectively. The features of the stent 721 including moresquared hinge arrangements 737,thinner interconnections ring interconnecting member 765′, and a more elongated and curvedend hinge arrangement 771 can facilitate, inter alia, flexibility of bending portions of the stent as well as improved uniformity upon expansion. -
FIG. 8 shows one of thehinge arrangements 737 interconnecting along strut 729 having fouropenings 777 with ashort strut 731 having three openings. Thehinge arrangements 737 of the embodiment ofFIGS. 7 and 8 each have a straightactive portion 780 which accommodates substantially all the bending during expansion of the stent. Theactive portion 780 is connected to thestruts curved portions 782. The curved portions are not significantly deformed during expansion of the stent due to their slightly larger width than the active portion and due to their location in the hinge arrangement. Specifically, the forces applied to the struts due to stent expansion in the direction of the arrows F result in a highest moment applied at a location M on the hinge arrangement. A length of theactive portion 780 of the hinge arrangement is selected to be long enough to provide acceptable peak strain while short enough to avoid excessive recoil. If the active portion of the hinge is very long, it will act like a spring. According to one preferred embodiment, theactive portion 780 of the hinge has a length to width ratio of between 4:1 and 1:1, preferably about 2:1 and the hinge arrangement is straight over this length. By straight it is meant that both sides of the hinge arrangement are substantially straight in the as-cut configuration. This means that the straight hinges 780 will be slightly curved in the crimped (delivery) configuration and also curved in the expanded configuration. - Since the struts within the stent 721 are of differing lengths throughout the stent, the
hinge arrangements 737 experience different moments applied by the different length struts. Thus, if the hinge arrangements were designed to be identical, the resulting expansion would be uneven. Some of thehinge arrangements 737 can be modified such as by changing the width or length of the active portion to achieve even expansion. For example, several locations within the stent 721 longer struts are used having five holes. These long five hole struts will exert a greater moment on the adjacent hinge arrangements due to their longer length than the three and four hole struts. Thus, the hinges adjacent the five hole struts can be wider and/or longer to achieve uniform expansion. This same principle applies anywhere there are variations in the lengths or shapes of the struts. To achieve a stent which opens evenly without certain hinges opening before others, the modified hinges are distributed in an uneven pattern on the stent which corresponds to the asymmetric structure of the stent. -
FIG. 9 shows one of theconnection hinge arrangements 739 of the stent ofFIG. 7 . Theconnection hinge arrangements 739 each include a passivecentral portion 784 and four activetapered hinge portions 786 connecting to fourstruts active hinge portions 786 are tapered with a narrow end connected to the struts and a wider end connected to the passivecentral portion 784. This tapered configuration achieves a distribution of the maximum strain along the tapered hinge. This is in contrast to a straight hinge which would result in concentrated strain in the hinge at a location closest to the central portion. According to one preferred embodiment, the activetapered hinge portions 786 have a length to width ratio of between 5:1 and 1:1, preferably about 3:1 where the width measured is the smallest width of the tapered hinge. - Stents according to embodiments of the present invention will be provided in a variety of sizes to match the anatomy of the body lumens to be supported. Typical coronary stent lengths are about 8 to 38 mm; circumferences in the closed state are about 1 to 2 mm; and circumferences in the open state are about 2 to 6 mm. Although sizes for coronary stents are described, other types of stents may also be made according to the present invention and their size will depend on their use.
- The length of a long strut in the embodiments described above is usually about 0.04″ to 0.09″ the length of a short strut is usually about 0.02″ to 0.06″; the length of an end ring strut is usually about 0.02″ to 0.09″. The width of a long strut in the embodiments described above is usually about 0.005″ to 0.01″; the width of a short strut is usually about 0.005″ to 0.01″; the width of an end ring strut is usually about 0.005″ to 0.01″. The length of an interconnection hinge arrangement including four hinges is usually about 0.01″ to 0.06″, and its width at the central portion is usually about 0.005″ to 0.02″. The tubing from which the stent is laser cut, and thus the struts, hinge arrangements, interconnection hinge arrangements, and other features of the stent generally have a thickness which depends on the material used and for cobalt chromium alloys a thickness of about 0.004″ to 0.006″.
- In the present application, the use of terms such as “including” is open-ended and is intended to have the same meaning as terms such as “comprising” and not preclude the presence of other structure, material, or acts. Similarly, though the use of terms such as “can” or “may” is intended to be open-ended and to reflect that structure, material, or acts are not necessary, the failure to use such terms is not intended to reflect that structure, material, or acts are essential. To the extent that structure, material, or acts are presently considered to be essential, they are identified as such.
- While this invention has been illustrated and described in accordance with a preferred embodiment, it is recognized that variations and changes may be made therein without departing from the invention as set forth in the claims.
Claims (17)
Priority Applications (10)
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US11/582,818 US8545545B2 (en) | 2006-10-18 | 2006-10-18 | Stent with flexible hinges |
US11/582,795 US20080097583A1 (en) | 2006-10-18 | 2006-10-18 | Stent with flexible hinges |
CN2007800450764A CN101594839B (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
EP11150517.8A EP2364675B1 (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
CN201110096062.3A CN102293694B (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
PCT/US2007/081732 WO2008049045A2 (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
CA2666857A CA2666857C (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
EP07854166A EP2083769A2 (en) | 2006-10-18 | 2007-10-18 | Stent with flexible hinges |
US13/041,827 US8353950B2 (en) | 2006-10-18 | 2011-03-07 | Stent with flexible hinges |
US13/927,702 US8974515B2 (en) | 2006-10-18 | 2013-06-26 | Stent with flexible hinges |
Applications Claiming Priority (3)
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US11/582,795 US20080097583A1 (en) | 2006-10-18 | 2006-10-18 | Stent with flexible hinges |
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US13/041,827 Active US8353950B2 (en) | 2006-10-18 | 2011-03-07 | Stent with flexible hinges |
US13/927,702 Expired - Fee Related US8974515B2 (en) | 2006-10-18 | 2013-06-26 | Stent with flexible hinges |
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US13/927,702 Expired - Fee Related US8974515B2 (en) | 2006-10-18 | 2013-06-26 | Stent with flexible hinges |
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AU2014265075B2 (en) * | 2010-08-02 | 2017-02-02 | Cardinal Health 529, Llc | Flexible helical stent having intermediate structural feature |
US9211203B2 (en) | 2012-12-20 | 2015-12-15 | Abbott Cardiovascular Systems, Inc. | Hinge for medical device |
CN112656543A (en) * | 2020-12-18 | 2021-04-16 | 王潇 | Peripheral vascular stent with reduced migration capability |
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CN102293694B (en) | 2015-06-03 |
CA2666857C (en) | 2015-02-03 |
US20110153003A1 (en) | 2011-06-23 |
EP2083769A2 (en) | 2009-08-05 |
US8353950B2 (en) | 2013-01-15 |
CN102293694A (en) | 2011-12-28 |
US20080097579A1 (en) | 2008-04-24 |
WO2008049045A3 (en) | 2008-09-25 |
US20130289707A1 (en) | 2013-10-31 |
EP2364675B1 (en) | 2015-12-16 |
CA2666857A1 (en) | 2008-04-24 |
US8974515B2 (en) | 2015-03-10 |
EP2364675A1 (en) | 2011-09-14 |
US8545545B2 (en) | 2013-10-01 |
WO2008049045A2 (en) | 2008-04-24 |
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