US20070225749A1 - Methods and devices for restoring blood flow within blocked vasculature - Google Patents
Methods and devices for restoring blood flow within blocked vasculature Download PDFInfo
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- US20070225749A1 US20070225749A1 US11/671,450 US67145007A US2007225749A1 US 20070225749 A1 US20070225749 A1 US 20070225749A1 US 67145007 A US67145007 A US 67145007A US 2007225749 A1 US2007225749 A1 US 2007225749A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/32056—Surgical snare instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00853—Material properties low friction, hydrophobic and corrosion-resistant fluorocarbon resin coating (ptf, ptfe, polytetrafluoroethylene)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00862—Material properties elastic or resilient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
- A61B2017/22034—Gripping instruments, e.g. forceps, for removing or smashing calculi for gripping the obstruction or the tissue part from inside
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22094—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for crossing total occlusions, i.e. piercing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2212—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
Definitions
- the devices and methods described herein relate to clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate the obstruction within the body lumen.
- the devices and methods described below may treat conditions of ischemic stroke by remove blockages within arteries leading to the brain. Accordingly, variations of such methods and devices must navigate tortuous anatomy and vasculature without causing unacceptable damage to the anatomy. Also, the devices and methods first secure and surround the obstruction (such as a clot) prior to significantly moving the clot within the anatomy.
- Ischemic stroke occurs when a blockage in an artery leading to the brain causes a lack of supply of oxygen and nutrients to the brain tissue.
- the brain relies on its arteries to supply oxygenated blood from the heart and lungs.
- the blood returning from the brain carries carbon dioxide and cellular waste. Blockages that interfere with this supply eventually cause the brain tissue to stop functioning. If the disruption in supply occurs for a sufficient amount of time, the continued lack of nutrients and oxygen causes irreversible cell death (infraction). Accordingly, immediate medical treatment of an ischemic stroke is critical for the recovery of a patient.
- the infraction may not develop or may be greatly limited given a rapid clearing of the blockage to reestablish the flow of blood.
- ischemic stroke may lead to the permanent loss of brain tissue, and can be marked by full or partial paralysis, loss of motor control, memory loss, or death.
- ischemic stroke Several different diseases may lead to an ischemic stroke. Typically, deposition of cholesterol (artherosclerosis), formation of blood clots, or other objects in the vessels may disrupt blood flow and lead to ischemic stroke. Furthermore, the substances that cause the blockages may break free from larger vessels outside the brain and become lodged within narrower arteries closer to the brain (embolism).
- Ischemic stroke may be divided into thrombotic strokes and embolic strokes.
- a thrombotic stroke occurs when the building and rupturing of atheromatous plaque within the brain blocks cerebral arteries. Clinically referred to as cerebral thrombosis or cerebral infraction, this condition represents approximately 10% of all strokes.
- An embolic stroke occurs when a clot or emboli forms somewhere other than in the brain, such as in the cervical carotid artery or in the heart, and travels in the bloodstream until the clot becomes lodged and can not travel any further. When such a condition occurs in the arteries supplying the brain, the condition results in almost immediate physical and neurological effects.
- ischemic stroke While these are the most common causes of ischemic stroke, there are many other possible causes. Examples include use of drugs, trauma to the blood vessels of the neck, or blood clotting disorders.
- t-PA Tissue Plasminogen Activator
- an embolectomy involves incising a blood vessel and introducing a balloon-tipped device (such as the Fogarty catheter) to the location of the occlusion.
- the balloon is then inflated at a point beyond the clot and used to translate the obstructing material back to the point of incision.
- the obstructing material is then removed by the surgeon.
- Concentric Medical, Inc. of Mountain View, Calif. supplies devices for an interventional approach to the removal of obstructions.
- Concentric supplies of Merci® Retriever system as a device based approach for the removal of clots. This system engages and ensnares a clot. Once captured, a balloon catheter inflates to temporarily halt forward blood flow while the clot is withdrawn. The clot is then pulled into the catheter and out of the body.
- the existing means to remove obstructions do not address the frictional forces that act on the obstruction during removal of the obstruction.
- some conventional devices engage the clot from the distal (or downstream) side. As the device is pulled proximally (or upstream), the device attempts to either engulf or ensnare the clot.
- the act of pulling the clot in a proximal direction cause the clot to also compress in an axial direction. This axial compression (when viewed along the axis of the vessel) causes a contemporaneous radial expansion of the clot (when viewed relative to the vessel).
- the increase in diameter of the clot causes an increase in the frictional forces applied against the arterial wall.
- the process of removing the clot may actually increase the static force that would otherwise be required to remove or translate the clot within the vessel.
- increasing the amount of force applied upon one side of the clot also increases the probability of complications during the procedure (e.g., fragmenting the clot, failing to remove the clot, failure to fully engulf/ensnare the clot, and/or device failure) and can cause potential damage to the surrounding vessel.
- obstructions may include blood clot, plaque, cholesterol, thrombus, naturally occurring foreign bodies (i.e., a part of the body that is lodged within the lumen), a non-naturally occurring foreign body (i.e., a portion of a medical device or other non-naturally occurring substance lodged within the lumen).
- the device allows for surrounding the obstruction prior to attempting to translate or move the obstruction within the vessel. It should be noted that although minimal axial movement of the obstruction may take place, the device surrounds the obstruction before such movement causes significant distortion to the geometry of the obstruction resulting in an increase in the static force required to remove the obstruction from the vessel.
- the device may include a low friction ode (such as a set of parallel wires, or wires extending axially along the lumen or vessel) that converts to an increased friction mode (such as a compressed set of wires acting on the obstruction or a twisted set of wires acting on the obstruction).
- the increase in friction is an increase in the friction between the obstruction and the device (as opposed to the vessel wall.
- the low friction modes is a low surface area mode and the high friction mode is a high surface area mode.
- the device When configured in the low friction mode, the device is better suited to engage the obstruction without the undesirable effect of prematurely mobilizing the obstruction or compacting the obstruction (e.g., when wires are slid across the obstruction in a transverse motion).
- the device Upon engaging the obstruction, the device will conform to a high friction mode with respect to the obstruction (in some cases the device will have an increased surface area mode). This high friction mode permits the device to better grip the obstruction for ultimate removal of the obstruction.
- the operation of the devices and method described herein secure the obstruction, overcome the elastic forces of the obstruction, then remove the obstruction from the anatomy without losing or fractionating the obstruction.
- this is accomplished by the obstruction removal device interacting with the obstruction in the following manner: (1) the traversing filaments traverse the obstruction by passing either through the obstruction or between the obstruction and the vascular wall; (2) the traversing portion is pulled proximally to engage the surrounding portion of the device around the obstruction, the surrounding portion engaging the obstruction without causing significant mobilization of the obstruction; (3) the obstruction removal device is pulled further proximally and the surrounding portion now mobilizes the obstruction.
- variations of the devices have a configuration that provides a path for a portion of the device to surround the obstruction.
- the paths are made using traversing filaments that allow for low frictional translation of a surrounding portion of the device over the obstruction without causing axial translation of the obstruction. This mechanism is described in more detail below.
- a portion of the device e.g., a surrounding portion
- the increase points of contact allow for removal of the obstruction through tortuous anatomy while ensuring that the obstruction will not escape the encapsulation.
- the surrounding portion may be fabricated in a variety of ways.
- the surrounding portion may comprise one or more filaments.
- the surrounding portion may comprise a filter/bag, a coil, helical filament, a mesh structure, corrugated sheet, braided filaments, single wound or crossing filaments, tubes, membranes, films, solid wires, filled tubes, castings.
- the surrounding portion may have one or more ports, openings, slits, and/or holes.
- the surrounding portion may be made by photochemical etching, mechanical drilling, weaving, braiding, laser cutting, or other means.
- surrounding or securing the obstruction includes partially and/or fully surrounding, engulfing, encapsulating, and/or securing the obstruction.
- the surrounding portion engages the obstruction prior to translation of the obstruction within the lumen.
- a portion of the device may convert into a surrounding section (e.g., when traversing wires reorient to increase the friction acting on the obstruction). Accordingly, the traversing section converts into a surrounding section.
- the various devices described herein rely on a reduced profile for delivery and an expanded profile for ultimate removal of the clot.
- the devices, or components of the devices may expand when released from a constraint, which allows the device, or component, to assume a predetermined shape.
- the devices may be actuated to assume the expanded profiles.
- the devices may be shape memory alloys that assume a profile when reaching a predetermined temperature (e.g., body temperature, or another temperature via delivery of energy to the shape memory alloy to trigger a phase change).
- Actuation may also include use any expandable member (such as a coiled spring, balloon, wedge, etc.) that mechanically or fluidly forces expansion of the device.
- the filaments of the invention may be sued to translate the device or may be used to form the surrounding section.
- the filaments may be single wound or crossing filaments, tubes, membranes, films, solid wires, filled tubes, castings or any similar structure.
- the cross section of such filaments may vary as required (e.g., circular, oval, rectangular, square, or any such shape.)
- the filaments may be constructed from metals, polymers, composites, hydrogels, membranes, shape memory metals, shape memory polymers, or shape memory alloys, superelastic metals, superelastic polymers, or superelastic alloys, or combinations thereof.
- the filaments may have uniform diameters or varying diameters. The characteristics of the filament may be selected to better suit their required function.
- the filaments may be braided or woven members, or the construction may provide that the filaments cross at one or many points in an overlapping, interwoven, criss-crossing or similar manner.
- the filaments used in the surrounding portion of the device
- the filaments of the surrounding portion may be coupled to an energy source (e.g., RF, ultrasonic, or thermal energy) to “weld” to the obstruction.
- an energy source e.g., RF, ultrasonic, or thermal energy
- the filaments may impart a positive charge to the obstruction to partially liquefy the obstruction sufficiently to allow for easier removal.
- a negative charge could be applied to further build thombus and nest the device for better pulling force.
- the filaments may be made stickier by use of a hydrophilic substance(s), or by chemicals that would generate a chemical bond to the surface of the obstruction.
- the filaments may reduce the temperature of the obstruction to congeal or adhere to the obstruction.
- FIG. 1 illustrates a system for removing obstructions from body lumens.
- FIG. 2A illustrates an example of an obstruction lodged within a body lumen.
- FIGS. 2B to 2 F illustrate advancement of a catheter beyond an obstruction and placement of traversing wires around the obstruction.
- FIG. 3A illustrates an obstruction removal device once converted to a high friction mode.
- FIGS. 3B to 3 E show variations of a device having filaments that do not cross one another over the length of the obstruction when converted to a high friction mode.
- FIGS. 3F to 3 G illustrate positioning a surrounding portion and translating the surrounding portion over the obstruction.
- FIGS. 3H to 3 I illustrate an obstruction removal device deployed distally to an obstruction and then translated proximally over the obstruction.
- FIGS. 4A to 4 E illustrate various additional configurations of devices able to assume a high friction mode covering over an obstruction.
- FIG. 4F illustrates a variation of a device using an end of a catheter for converting the device to a high friction mode.
- FIGS. 5A to 5 B illustrate another variation of a portion of an obstruction removal device configured to convert from a low friction mode to a high friction mode.
- FIGS. 6A to 6 G illustrate various configurations of connectors for use with obstruction removal devices.
- FIGS. 6H to 6 I illustrate a variation of a leading wire and connector having an unconstrained shape that is selected to be larger or simply different than the intended vessel to provide increased stability upon deployment.
- FIG. 7A to 7 D illustrates variations in which the connector is offset.
- FIGS. 8A to 8 B illustrate hooks, fibers, and/or barbs for increasing the ability of the device to remove obstructions.
- FIGS. 9A to 9 C illustrate additional variations of obstruction removal devices.
- FIGS. 10A to 10 H also illustrate additional variations of obstruction removal devices, focusing mainly on variations of the surrounding portion.
- FIGS. 11A to 11 C illustrate a variation where use of mechanical expansion distends the vessel wall and loosens the obstruction from the vessel.
- FIG. 1 illustrates a system 10 for removing obstructions from body lumens as described herein.
- this variation of the system 10 is suited for removal of an obstruction in the cerebral vasculature.
- the system 10 includes a catheter 12 microcatheter, sheath, guide-catheter, or simple tube/sheath configuration for delivery of the obstruction removal device to the target anatomy.
- the catheter should be sufficient to deliver the device as discussed below.
- the catheter 12 may optionally include an inflatable balloon 18 for temporarily blocking blood flow or for expanding the vessel to release the obstruction.
- catheters or microcatheters may be used to locate the catheter/microcatheter 12 carrying the obstruction removal device (not illustrated) at the desired target site.
- auxiliary or support components 14 , 16 e.g., energy controllers, power supplies, actuators for movement of the device(s), vacuum sources, inflation sources, sources for therapeutic substances, pressure monitoring, flow monitoring, various bio-chemical sensors, bio-chemical substance, etc.
- auxiliary or support components 14 , 16 e.g., energy controllers, power supplies, actuators for movement of the device(s), vacuum sources, inflation sources, sources for therapeutic substances, pressure monitoring, flow monitoring, various bio-chemical sensors, bio-chemical substance, etc.
- devices of the present invention may be packaged in keys including the components discussed above along with guiding catheters, various devices that assist in the stabilization or removal or the obstruction (e.g., proximal-assist devices that holds the proximal end of the obstruction in place preventing it from straying during removal or assisting in the removal of the obstruction), balloon-tipped guide catheters, dilators, etc.
- proximal-assist devices that holds the proximal end of the obstruction in place preventing it from straying during removal or assisting in the removal of the obstruction
- balloon-tipped guide catheters e.g., dilators, etc.
- FIGS. 2A to 2 F show one example of the deployment of the basic structure of connectors and traversing filaments about an obstruction in a vessel.
- the figures are intended to demonstrate the initial placement of the connectors and filaments immediately prior to removal of the obstruction either using a filter or by torquing, rotating and/or twisting the near connector relative to the far connector. This action converts the device from a low friction device to a high friction device (where the low/high friction is the friction between the device and the obstruction).
- This action may also be referred to as a low surface area mode converting to a high surface area mode (in cases where the device extends beyond the obstruction and relative motion between ends of the device causes the device to shrink in axial length as it is twisted.)
- the number of connectors used, the shape of the connectors, as well as the number of filaments is intended to be for illustrative purposes only. It is contemplated that any variation of connector and/or filament may be deployed in a similar manner.
- FIG. 2A illustrates an example of an obstruction 2 lodged within a body lumen or vessel 6 .
- the obstruction may result in an ischemic stroke.
- a microcatheter 102 and guidewire 104 traverse the obstruction.
- the microcatheter 102 may be advanced through the obstruction 2 .
- the microcatheter 102 may “push” aside the obstruction and is advanced around the obstruction.
- the microcatheter 102 travels from the near end 3 (or proximal side) of the obstruction 2 to the far end 4 (or distal side) of the obstruction 2 .
- the catheter 102 may be centered or off-center with respect to the obstruction 2 .
- the device may or may not be used with a guidewire to navigate to the site and traverse the obstruction.
- FIG. 2B shows another variation where a microcatheter 102 traverses the obstruction 2 between the wall of the vessel 6 and the obstruction 2 .
- the open end of the microcatheter 102 is distal to the obstruction 2 and is now positioned to deploy devices for removal of the obstruction 2 .
- This variation shows the device after removal of any guidewire.
- some variations of the device may be placed without an accompanying guidewire.
- the structures discussed herein may be directly incorporated into a guidewire assembly where deployment may require a sheath or other covering to release the components from constraint.
- FIG. 2C illustrates deployment of a far connector 110 from within the microcatheter 102 distal to the obstruction 2 .
- the far connector 110 can be self-expanding such that it assumes, or moves towards, the expanded profile (as shown) upon deployment from the constraint of the microcatheter 102 .
- the connectors 108 , 110 and/or traversing filaments 112 are designed to expand to the wall of the vessel when released from the catheter. This action allows the device 100 to surround the obstruction 2 prior to attempting to dislodge it.
- the components of the obstruction removal device 100 e.g., the leading wires 106 , the connectors 108 , 110 , the traversing filaments 112 , and/or the surrounding portion 114 ) may be fabricated from any biocompatible material that permits the function as described herein. In some variations, that material may comprise a shape memory or super-elastic alloy such as nitinol.
- FIG. 2D shows withdrawal of the microcatheter 102 to the proximal side 3 of the obstruction 2 .
- the spacing between the far connector 110 and the obstruction 2 may vary. In some cases, the far connector 110 will move closer towards the obstruction 2 during spacing of the traversing filaments 112 as discussed below. The far connector 110 remains in place either using the inherent friction of the connector against the vessels and/or obstruction 2 .
- a wire-type member (not shown) may provide an opposing force against the connector 110 as the catheter 102 moves proximal to the obstruction 2 .
- the obstruction removal devices include a plurality of filaments affixed between connectors. Since the far connector 110 is deployed at the distal side 4 of the obstruction 2 , withdrawal of the microcatheter 102 results in the plurality of filaments 112 spanning across the obstruction 2 as shown.
- FIG. 2E illustrates deployment of a near connector 108 .
- the illustrated variation depicts the near connector 108 as being deployed from within the microcatheter 102
- alternative variations of the device include a near connector 108 that is located about the exterior of the microcatheter 102 or that is located about another delivery device (not shown) that is external to the microcatheter 102 .
- the near connector 108 is similar in profile and design to the far connector 110 .
- the near connector 108 self expands within the vessel 6 upon deployment from the microcatheter 102 .
- the near and far connectors 108 , 110 may have different shapes or profiles. In any case, the profile of the connectors should be sufficient to expand the traversing wires sufficiently within the vessel to prepare for ensnaring or encapsulation of the obstruction 2 .
- FIG. 2E also illustrates a connecting or leading wire/member 106 that couples the microcatheter 102 to the near connector 108 .
- leading wire, leading member, lead wire, etc. is intended to encompass a wire, tube, or any other structure that organizes and sometimes houses the smaller traversing filaments and/or near connectors described herein.
- variations of the device include a leading wire 106 that is affixed to the far connector or the traversing wires.
- the illustration depicts a single leading wire 106 .
- the device can include a number of traversing wire 106 affixed to the near and/or far connectors 108 , 110 .
- FIG. 2F illustrates spacing the traversing filaments/wires 112 from simply spanning the obstruction 2 (as depicted in FIG. 2E ). This action causes the filaments 112 to span the obstruction 2 while reorienting towards an exterior of the obstruction 2 . As noted herein, the traversing filaments 112 may remain partially or fully within the obstruction 2 . However, given that the filaments are spaced about the connectors, the filaments shall separate radially over the obstruction allowing for the subsequent ensnaring and removal.
- the filaments may occur via a number of modes such as tensioning, expanding, spreading separating and/or withdrawing the filaments.
- the filaments are moveable relative to a near connector and/or a far connector. Such a feature allows application of tension to the filaments while keeping the connector in place. This causes the filament to enter a state of tension for spacing about the wall of the vessel.
- the filaments may be fixed relative to the connectors. Upon deployment the filaments either self expand or are actuated to space about the vessel wall for eventual translation of the device over the obstruction. Regardless of the mode used, the filaments are intended to be positioned at or near a surface of the obstruction so that they can reduce the effects of any friction between the obstruction and the lumen or vessel wall.
- FIGS. 3A to 3 I provide illustrations of device variations that ensnare the obstruction 2 after the device is in the configuration demonstrated by FIG. 2F above.
- FIGS. 3A, 3C , and 3 E represent variations of the device 100 after transforming from a low friction mode to a higher friction mode for removal of the obstruction.
- FIGS. 3F and 3G illustrate a variation where a surrounding portion of filter covers the obstruction for its ultimate removal from the body.
- FIG. 3A illustrates rotation of the near connector 108 relative to the far connector 110 to ensnare the obstruction 2 within the traversing wires 112 .
- either connector may rotate while another connector remains stationary.
- each connector may rotate with the rate of rotation for one connector being slower than another.
- each connector may be rotated in opposite directions.
- FIG. 3A illustrates the obstruction removal device 100 after rotation of the sets of traversing filaments and connectors. The result is that the obstruction 2 becomes ensnared (and/or encapsulated) and may be removed from the body. It should be noted that the same effect may be achieved by only rotating one connector or set of wires while keeping the other connector or set of wires stationary.
- the rotation of the connector 108 can be performed in any number of ways as known to those skilled in the art. However, as shown in FIG. 3A , the lead wire 106 may comprise additional secondary wires attached to the connector 108 . So rotation of the connector 108 may occur via rotation of the lead wire and/or microcatheter. In any case, once the device assumes the increased friction mode condition, the obstruction 2 can be moved laterally within the vessel for removal.
- FIGS. 3A to 3 E illustrate various configurations where relative rotation of the connectors 108 , 110 convert the device into a high friction mode.
- the traversing filaments 112 twist and cross one another over the length of the obstruction 2 .
- variations of the device 100 can have filaments 112 that do not cross one another over the length of the obstruction 2 .
- these variations are depicted to have single connectors on each end and four filaments, the design of the devices may vary as required by the particular application.
- the variations shown in FIG. 3B to 3 E are shown without any catheter or leading wire for convenience to better illustrate the conversion of the device from a low friction mode to a high friction mode. Naturally, rotation of the catheter and/or lead wire will cause relative rotation between connectors.
- FIG. 3B the device 100 is in a similar position as that shown in FIG. 2E .
- FIG. 3B shows a variation of a device 100 that is is selected to have a length greater than the targeted obstruction 2 .
- the traversing filaments 112 remain uncrossed over the length of the obstruction 2 .
- the filaments 112 may experience some twisting and will not remain parallel.
- the filaments 112 twist at twist points 116 that are proximal to and distal to the obstruction 2 .
- the relative motion of the connectors 108 , 110 as well as the twist point 116 causes the filaments 112 to exert a compressive force on the obstruction 2 without crossing one another over the length of the construction. Accordingly, while the surface area in contact between the filaments 112 and obstruction 2 remains relatively the same, the compressive action of the filaments 112 onto the obstruction converts the device 100 to a high friction mode on the obstruction.
- FIG. 3D illustrates another variation of a device in a similar position as that shown in FIG. 2E .
- FIG. 3D shows a variation of a device 100 that extends proximally from the near end of the obstruction 2 .
- the relative motion between connectors 108 , 110 cause a twist point 116 that is proximal to the obstruction 2 .
- the twist point 116 forces the filaments 112 against the obstruction 2 without crossing one another over the length of the obstruction 2 .
- the device 100 is now in high friction mode.
- the filaments 12 may experience some twisting and will not remain parallel.
- FIGS. 3D to 3 E also show the device 100 as including a cap or cover 118 about the distal connector 110 .
- the cap or cover 118 may be a bag, mesh, a continuation of the filaments 112 , and/or a surrounding portion 114 as discussed herein.
- the cap or cover 118 reduces the likelihood that the obstruction is driven through the far connector 110 during conversion of the device 100 from a low friction mode to a high friction mode.
- FIG. 3F illustrates another variation of a device where the far connector 110 includes a filter or surrounding portion 114 .
- the filter 114 is sufficiently permeable to allow blood flow therethrough.
- the surrounding portion 114 may be any structure that covers, encapsulates, engulfs, and/or ensnares the obstruction either fully or partially.
- the surrounding portion 114 may comprise a coil, helical wire, a plurality of filaments, mesh structure, corrugated sheet, braided filaments, single wound or crossing filaments, tubes, filled tubes, castings, solid wires, membranes, films, capturing sections, (and may include ports, openings, slits, and/or holes made from photochemical etching, mechanical drilling) or any other structure that may translate or remove the obstruction 2 once the frictional component is addressed.
- the obstruction removal device 100 includes leading filaments 106 connected to a near connector 108 .
- the lead filament 106 may be a single wire or filament.
- the lead filament may comprise a single wire with a plurality of wires connecting the single wire to the ring.
- the illustrated variation shows the connector 108 as comprising a loop.
- the connectors may also comprise various alternate shapes (e.g., a circle, an arcuate shape, a partial circular shape, a loop, an oval, a square, a rectangle, a polygon, an overlapping loop, a pair of semi-circles, a flower shape, and a figure 8, other shapes, etc.)
- the near connector 108 is joined to a far connector 110 via a plurality of filaments 112 .
- the inventive device shall include at least one, but preferably two or more traversing filaments 112 .
- the obstruction removal device 100 may be part of or integrated with the microcatheter 102 .
- FIG. 3G illustrates withdrawal of the microcatheter 102 and the proximal translation of device 100 to place the surrounding portion 114 over the obstruction 2 .
- the traversing filaments 112 locate towards the exterior region of the obstruction 2 .
- the connectors 108 , 110 and traversing filaments 112 are designed to expand to (or near to) the perimeter of the wall of the vessel 2 and will usually locate to an exterior of the obstruction 2 .
- variations of the device and method include situations where the filaments locate substantially, but not fully, towards the outer region of the obstruction. In any case, the location of the filaments 112 will sufficiently overcome the frictional forces discussed herein.
- the traversing filaments 112 substantially span the length of the obstruction 2 by extending across the (proximal) 3 and (distal) 4 sides. These traversing filaments 112 provide paths for movement of the device 100 around the obstruction 2 . These paths allow for the surrounding portion 114 to engulf the entire obstruction 2 so that it may be removed from the vasculature and body.
- FIG. 3H depicts an obstruction removal device 100 similar to that shown in FIG. 3F .
- the near and far connectors 108 , 110 are both deployed distally to the obstruction 2 and then translated back over the obstruction 2 .
- this deployment allows the traversing filaments 112 and the surrounding portion 114 to separate prior to contacting the occlusion 2 .
- the entire device 100 is pulled over the occlusion 2 as described above.
- the variation of the device shown in FIGS. 3F and 3H addresses the frictional forces that act between the obstruction and the vessel wall.
- Conventional devices that provide a bag attached to a wire are typically unable to remove the obstruction because they cannot overcome these frictional forces that lodge the clot against the vessel wall.
- vascular filter or distal protection device are typically unable to remove the obstruction because they cannot overcome these frictional forces that lodge the clot against the vessel wall.
- conventional devices are only designed to “catch” free floating clots.
- the traversing filaments described herein are configured to be positioned surrounding the obstruction. Their low friction with respect to the clot and the vessel allows for positioning of the filaments without disrupting or further compacting the clot against the vessel wall. Once the filaments surround or are spaced about the obstruction, they reduce the friction between the clot and vessel wall by reducing points of contact. Once these filaments surrounded the clot, they permit translation of the device to permit an encapsulating section 114 to surround the obstruction for removal.
- FIG. 3I illustrates the device 100 of FIG. 3H when translated over the obstruction 2 .
- the device 100 is pulled so that the surrounding portion or blood permeable filter 114 covers the obstruction 2 (as shown in FIGS. 3F and 3G .
- FIG. 4A illustrates another variation of a portion of an obstruction removal device 120 that is able to convert from a low friction mode covering to a higher friction mode covering.
- this variation allows the medical practitioner to engage an obstruction with sparse coverage or low friction mode to overcome frictional forces.
- the device configuration Upon properly engaging the obstruction, the device configuration allows conversion to a high friction mode for removal of the device and obstruction.
- this variation of the obstruction removal device 120 includes two sets of traversing filaments 122 , 124 and accompanying connectors 108 , 110 , and 126 , 128 .
- the first set 122 comprises a first near connector 108 and first far connector 110 with the accompanying traversing filaments.
- the second set 124 comprises the second near connector 126 and second far connector 128 with the accompanying traversing filaments 124 .
- the second set 124 is coaxially located over the first set 122 .
- the materials of the components may be as described above. In any case, the components are designed to expand to the perimeter of the vessel wall upon release from the catheter.
- FIG. 4B shows the conversion of the obstruction removal device converting from a low friction mode (from FIG. 4A ) to the high friction mode.
- the first near connector 108 may be rotated relative to the second near connector 126 (where the second near connector may remain still or it may be rotated in an opposite direction relative to the first near connector as shown by the arrows).
- the traversing filaments 122 , 124 deform in opposite directions to form a braid-type pattern increasing the friction mode over the obstruction.
- FIG. 4C illustrates another variation of an obstruction removal device 100 in a low friction mode state.
- the device 100 includes a near connector 108 , a far connector 110 with traversing filaments between the connectors 108 , 110 .
- the device 100 also includes an additional connector 132 with non-rotating filaments 134 extending to the far connector 110 .
- FIG. 4D illustrates the device 100 of FIG. 4C when the near connector 108 is rotated as shown by arrow 136 . However, the additional connector 132 and associated filaments 134 do not rotate. Upon rotation of the near connector 108 and twisting of the filaments 112 , all of the filaments 112 and 134 compress the obstruction over the length of the filaments. Such a feature creates additional friction on the obstruction by the device.
- FIG. 4E shows another variation of an obstruction removal device 100 configured to move between low and high friction mode states.
- This variation includes additional support rings 138 located between connectors 108 , 110 and within the filaments 112 .
- the support rings keep the device 100 at a relatively constant diameter upon assuming the increased friction mode state.
- the support rings may be slightly undersized compared to the connectors, allowing the filaments to slightly compress the obstruction when converted to a high friction mode, but limiting the amount of compression by limiting the resulting diameter.
- the support rings 138 can be freely placed within the traversing filaments 112 . Alternatively, the rings 138 can be attached to one or more than one filament 112 to prevent undesired migration during deployment of the device.
- FIG. 4F illustrates one example of a microcatheter 102 having a near connector 108 located externally to the catheter 102 with traversing filaments 112 extending out of the catheter and through the connector 108 .
- rotation or torquing of the catheter 102 twists the filaments 112 resulting in increased friction mode of the filaments 112 over an obstruction.
- FIG. 4F illustrates an additional connector 132 having stationary filaments 134 .
- This variation of the device includes the external connector 108 directly coupled to a far connector (not shown.)
- FIG. 5A illustrates a variation of the device 120 having only connectors 108 at one side of the device 120 .
- the device 120 may still include two sets 108 , 122 of connectors and two sets of traversing filaments 112 , 124 .
- FIG. 5B illustrates the variation of FIG. 5A after conversion to a high friction mode over the obstruction 2 .
- the connectors may be other structures than loops.
- variations of the invention include connectors that may be drawn down to a smaller size to facilitate removal from the body after securing the obstruction. This may be accomplished by torquing the device or part thereof, by re-sheathing part or all of the device, or by any mechanical means designed into the features of the device itself. Any of these actions, or combination thereof, may also serve to compress or decrease the diameter of the obstruction itself to facilitate removal from the body.
- the devices described herein may be assembled or constructed in-situ.
- components of the device may include connectors, portions of the connectors, traversing elements, and/or surrounding sections. Any combination of these components can be placed in sequential fashion. Doing so forms a completed structure from deployment of a number of individual components. The end result is the formation of a device as shown in the figures. Accordingly, such components of the device may be separately deployed in a manner that requires “assembly” of the components by a medical practitioner during the procedure.
- FIGS. 6A-6G illustrate variations of the connectors 108 , 110 .
- FIG. 6A shows a loop-shaped connector 108 , 110 having attachment points 140 for the filaments (not shown).
- the connectors can be self-expanding or actuated to expand.
- the connectors may be fabricated from a polymer, a shape memory metal, polymer, or alloy, a super-elastic metal, polymer, or alloy, or any type of acceptable medical grade alloy, polymer, or composite structure.
- the devices described herein can be fabricated from solid material, sheet or film, hollow or solid or filled rod or wire, braids, coils, etc. In the case of the polymer, additional strength may be added by constructing a composite layered device.
- some variations of the device may include a distal connector having a cap or cover to prevent the obstruction from escaping as the device is removed.
- the sizing of the connectors within the vessel can assist in controlling relative rotation between connectors. For example, as a connector moves towards its expanded shape and engages a vessel or lumen wall, the rotational friction between the connector and lumen wall may prevent rotation. Accordingly, an adjacent connector may have a smaller expanded profile so that the connector experiences less friction when rotated.
- FIG. 6A also illustrates the connector as having attachment points 140 for coupling the filaments to the connectors. These attachment points may allow for movement of the filaments relative to the connector to tension or separate the connectors (as described above.)
- the filaments may also be coupled such that they are fixed relative to the connectors. In such a case, pulling of the lead wire will cause the entire assembly (e.g., connectors, filaments, and/o surrounding portion) to translate through the vessel.
- FIGS. 6B through 6G show various configurations of connectors for use in the present device.
- the connectors may be cut from sheets, fabricated from wire, molded, stamped, laser cut, photo or chemically etched, or fabricated in any other customary manner.
- the connectors 108 , 110 shown may be used in the near and/or far ends of the traversing wires. Different connector profiles may be incorporated into the device. In most cases, as shown, the connectors will form an arcuate shape so that they can expand against a vessel wall without causing trauma to the vessel.
- FIGS. 6B to 6 E are shown without any accompanying traversing filaments.
- FIG. 6B shows a connector 108 , 110 that is a loop shape as shown above.
- alternative configurations include a discontinuous profile, as illustrated in FIG. 6C and an overlapping profile, as illustrated in FIG. 6D .
- Such constructions allows the connector to adjust to varying diameters of body lumens.
- a device may comprise loops of either construction.
- loops are shown, other variations may work equally well.
- Variations of the invention include connectors that may be drawn down to a smaller size to facilitate removal from the body once the obstruction is secured. This may be accomplished by torquing the device or part thereof, by re-sheathing part or all of the device or by any mechanical means designed into the features of the device itself.
- any of these actions, or combination thereof, may also serve to compress or decrease the diameter of the obstruction itself to facilitate removal from the body.
- the overlapping connector as shown in FIG. 6D , may include a sliding ring type fastener that allows the overlapping connector loop to expand in the same plane.
- the device may be fabricated from a polymer composite that makes up the fasteners, filaments, bags, etc. where the polymeric composite is very floppy until it is exposed to either the body fluids and or some other delivered activator that causes the polymer to further polymerize or stiffen for strength.
- Various coatings could protect the polymer from further polymerizing before the device is properly placed.
- the coatings could provide a specific duration for placement (e.g., 5 minutes) after which the covering degrades or is activated with an agent (that doesn't affect the surrounding tissues) allowing the device to increase in stiffness so that it doesn't stretch as the thrombus is pulled out.
- shape memory polymers would allow the device to increase in stiffness.
- FIG. 6E shows a connector 108 , 110 having multiple sections 146 .
- the connector sections 146 are arcuate shaped to minimize trauma to a vessel wall.
- other shapes are also intended to be within the scope of this disclosure.
- FIGS. 6B through 6G also illustrate various configurations of leading wires 106 .
- the connectors may have any number of leading wires. In some variations, it may be desirable to space the leading wires about the profile of the connector to aid in uniform movement of the device as it is pulled over the obstruction in the vessel.
- FIGS. 6F and 6G illustrate additional variations of leading wires 106 comprising shaped wire structures that form a “c” portion 142 of the connector.
- leading wires 106 comprising shaped wire structures that form a “c” portion 142 of the connector.
- the “c” shaped portions 142 move together to allow for delivery within the catheter.
- the portions 142 assume their resting shape and expand within the vessel.
- the connecting portions 142 can be selected to have a size that is slightly greater than that of the vessel. Sizing the device relative to the target vessel may assist in placing the connecting portions 142 and accompanying traversing wires 112 against the wall of the vessel.
- FIG. 6G shows an additional variation where a portion 144 of a leading wire 106 also has a “c” or semi-circular shape.
- the “c” shaped portion 144 of the leading wire 106 can also be sized relative to the target vessel. Accordingly, the portion 144 of the leading wire 106 functions to drive the connecting portion 142 against the vessel wall, while the shape of the connecting portion 142 also drives the traversing wire 112 against the vessel wall.
- FIG. 6H illustrates another variation of a leading wire 106 having an unconstrained shape that is selected to be larger than the intended vessel or simply different than a cross sectional profile of the intended vessel (i.e., not circular or tubular, but e.g., linear or other different shape).
- the leading wire 106 has portions 144 that extend in opposite directions.
- This configuration is intended for illustrative purposes only. Variations include connecting portions pointing in an orthogonal direction from the main lead wire 106 , oblique, parallel (as shown), or a combination thereof.
- the unconstrained shape is intended to have a larger profile or size than the intended vessel.
- the unconstrained shape may have an entirely different profile than the intended vessel.
- the profile of the device extends radially from the vessel. So when the device and leading wire are released, the leading wire attempts to return to the unconstrained shape. In those variations where the unconstrained shape is different from the circular profile of the vessel, the leading wire assumes a shape that accommodates the vessel but is more rigid and stable since its unconstrained shape is entirely different from that of the vessel.
- FIG. 6I shows the same device of FIG. 6H when released from a microcatheter, sheath, or tube when in the vessel.
- the leading wire 106 and accompanying portions 144 attempt to revert to the unconstrained shape (as shown in FIG. 6H ).
- the vessel 6 restrains the leading wire 106 and portions 144 such that the portions 144 act on the walls of the vessel. This feature allows for improved stability when deploying the leading wires and attached connectors and filaments within the vessel.
- FIGS. 7A through 7C illustrate variations of connectors 108 , 110 where the connector portions are axially spaced by an offset 152 .
- One benefit of placing the connector portions 142 , 146 in different planes is that the device may be delivered via a smaller microcatheter because the connector portions may be collapsed to a smaller diameter.
- FIG. 7A illustrates an offset 152 between connector portions 142 where each portion 142 is coupled to leading wires 148 , 150 of varying lengths.
- FIG. 7B illustrates connector portions 146 spaced axially along a leading wire 106 to provide a gap 152 .
- FIG. 7C illustrates a connector 108 , 110 having multiple components 146 where one or more components is axially spaced to provide a gap 152 .
- FIG. 7D shows a variation 108 , 110 having a flower shape where each connector portion 146 is non-planar such that the gap 152 occurs over the length of the connector portion 146 .
- Another aspect applicable to all variations of the devices is to configure the devices (whether the traversing filament or the surrounding portion) for better adherence to the obstruction.
- One such mode includes the use of coatings that bond to certain clots (or other materials causing the obstruction.)
- the traversing filament and/or surrounding portion may be coated with a hydrogel or adhesive that bonds to a thrombus. Accordingly, as the surrounding portion covers the clot, or as the device twists about the clot, the combination of the additive and the mechanical structure of the device may improve the effectiveness of the device in removing the obstruction.
- the traversing members may have hooks, fibers, or barbs 154 that grip into the obstruction when the device converts to a high friction mode.
- the hooks, fibers, or barbs 154 may also be incorporated into the surrounding portion.
- FIG. 8B illustrates a magnified view of the area 8 B from FIG. 8A .
- the barbs may be configured such that rotation in a particular direction causes the barbs to adhere to the obstruction. Such a configuration could also allow lateral movement without the barbs interfering with the vessel.
- the device can be coupled to an RF or other power source (such as 14 or 16 in FIG. 1 ), to allow current, ultrasound or RF energy to transmit through the device and induce clotting or cause additional coagulation of a clot or other the obstruction.
- an RF or other power source such as 14 or 16 in FIG. 1
- the methods described herein may also include treating the obstruction prior to attempting to remove the obstruction.
- a treatment can include applying a chemical or pharmaceutical agent with the goal of making the occlusion shrink or to make it more rigid for easier removal.
- agents include, but are not limited to chemotherapy drugs, or solutions, a mild formalin, or aldehyde solution.
- the devices and methods described herein may also be useful in removing obstructions lodged within bifurcations in the anatomy.
- bifurcations greatly increase the frictional forces on the obstructions since the obstruction tends to be lodged in both branching sections of the bifurcation.
- the use of the presently described devices and methods may also include an additional “puller” device that advances beyond the portion of the obstruction partially located in the bifurcated vessel.
- FIGS. 9A through 9C illustrate additional variations of obstruction removal devices.
- the traversing filaments 112 may comprise a mesh of wires or single connector.
- FIGS. 9A to 9 B illustrate a variation in which the connector 108 comprises a wire rather than a loop.
- the filaments and connectors should be configured to expand to the perimeter of the vessel wall as described previously.
- FIGS. 10A-10H illustrate various additional embodiments of obstruction removal devices 130 according to the present invention.
- the connector 108 may form a rigid wire or hard polymer to assist in placement of the device 130 .
- the surrounding portion 132 may be fabricated from less rigid filaments that increase the point of contact with the obstruction.
- the surrounding portion may also have filaments that undergo a phase change from non-rigid (or less rigid) or rigid.
- traversing filaments 112 or sets may be used in these variations.
- the methods and or devices may include expansion of the vessel wall adjacent to the obstruction either with a balloon, coil, or similar mechanical expansion means, drugs, fluids, etc. Such an improvement may aid where the obstruction expands part of the vessel wall thereby increasing the amount of force required for displacement. By distending the vessel wall as described above, the forces on the obstruction may be reduced allowing for ease of removal.
- FIG. 11A illustrates an obstruction 2 embedded within the vessel 6 .
- FIGS. 11B to 11 C illustrate variations where use of a coil ( FIG. 11B ) or a non-distensible balloon 162 ( FIG. 11C ) proximal to the obstruction 2 distends the vessel wall to loosen the obstruction 2 from the vessel. Accordingly, devices (whether described herein or other conventional devices) may then remove the obstruction 2 .
- the expansion means may be located on the delivery catheter of the obstruction removal device, on a wire member of the device, and/or a separate catheter or wire used in combination with the first delivery catheter.
- variations of such configurations are within the scope of the invention.
- devices and methods described herein may also use balloons proximal to the obstruction to stop or slow blood flow thereby preventing the blood from dislodging part or all of the obstruction.
Abstract
The devices and methods described herein to clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen.
Description
- This application is a non-provisional of U.S. Provisional Application No. 60/765,496 filed Feb. 03, 2006 which is incorporated by reference in its entirety.
- The devices and methods described herein relate to clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate the obstruction within the body lumen. In one variation, the devices and methods described below may treat conditions of ischemic stroke by remove blockages within arteries leading to the brain. Accordingly, variations of such methods and devices must navigate tortuous anatomy and vasculature without causing unacceptable damage to the anatomy. Also, the devices and methods first secure and surround the obstruction (such as a clot) prior to significantly moving the clot within the anatomy.
- Ischemic stroke occurs when a blockage in an artery leading to the brain causes a lack of supply of oxygen and nutrients to the brain tissue. The brain relies on its arteries to supply oxygenated blood from the heart and lungs. The blood returning from the brain carries carbon dioxide and cellular waste. Blockages that interfere with this supply eventually cause the brain tissue to stop functioning. If the disruption in supply occurs for a sufficient amount of time, the continued lack of nutrients and oxygen causes irreversible cell death (infraction). Accordingly, immediate medical treatment of an ischemic stroke is critical for the recovery of a patient.
- The infraction may not develop or may be greatly limited given a rapid clearing of the blockage to reestablish the flow of blood. However, if left untreated, ischemic stroke may lead to the permanent loss of brain tissue, and can be marked by full or partial paralysis, loss of motor control, memory loss, or death.
- Several different diseases may lead to an ischemic stroke. Typically, deposition of cholesterol (artherosclerosis), formation of blood clots, or other objects in the vessels may disrupt blood flow and lead to ischemic stroke. Furthermore, the substances that cause the blockages may break free from larger vessels outside the brain and become lodged within narrower arteries closer to the brain (embolism).
- Ischemic stroke may be divided into thrombotic strokes and embolic strokes. A thrombotic stroke occurs when the building and rupturing of atheromatous plaque within the brain blocks cerebral arteries. Clinically referred to as cerebral thrombosis or cerebral infraction, this condition represents approximately 10% of all strokes. An embolic stroke occurs when a clot or emboli forms somewhere other than in the brain, such as in the cervical carotid artery or in the heart, and travels in the bloodstream until the clot becomes lodged and can not travel any further. When such a condition occurs in the arteries supplying the brain, the condition results in almost immediate physical and neurological effects.
- While these are the most common causes of ischemic stroke, there are many other possible causes. Examples include use of drugs, trauma to the blood vessels of the neck, or blood clotting disorders.
- Apart from surgical techniques, medical practitioners could address such blockages with the use of Tissue Plasminogen Activator (t-PA). However, t-PA must be used within the first three hours of the onset of stroke symptoms and may take hours or even days to successfully restore flow. In addition, t-PA carries an increased risk of intracerebral hemorrhage. It is currently believed that the use of t-PA results in a 30% success rate as well as a 6% major complication rate. In view of these limitations, the majority of stroke patients in the U.S. do not receive t-PA treatment.
- In addition, there are a number of surgical techniques used to remove blockages. For example, an embolectomy, involves incising a blood vessel and introducing a balloon-tipped device (such as the Fogarty catheter) to the location of the occlusion. The balloon is then inflated at a point beyond the clot and used to translate the obstructing material back to the point of incision. The obstructing material is then removed by the surgeon. Concentric Medical, Inc. of Mountain View, Calif. supplies devices for an interventional approach to the removal of obstructions. Concentric supplies of Merci® Retriever system as a device based approach for the removal of clots. This system engages and ensnares a clot. Once captured, a balloon catheter inflates to temporarily halt forward blood flow while the clot is withdrawn. The clot is then pulled into the catheter and out of the body.
- Typically, the existing means to remove obstructions do not address the frictional forces that act on the obstruction during removal of the obstruction. For example, some conventional devices engage the clot from the distal (or downstream) side. As the device is pulled proximally (or upstream), the device attempts to either engulf or ensnare the clot. However, due to the consistency of the clot and because the clot is typically well lodged within the vessel, the act of pulling the clot in a proximal direction cause the clot to also compress in an axial direction. This axial compression (when viewed along the axis of the vessel) causes a contemporaneous radial expansion of the clot (when viewed relative to the vessel). As a result, the increase in diameter of the clot causes an increase in the frictional forces applied against the arterial wall. Thus, by not addressing the frictional forces acting on the obstruction, the process of removing the clot may actually increase the static force that would otherwise be required to remove or translate the clot within the vessel. Unfortunately, increasing the amount of force applied upon one side of the clot also increases the probability of complications during the procedure (e.g., fragmenting the clot, failing to remove the clot, failure to fully engulf/ensnare the clot, and/or device failure) and can cause potential damage to the surrounding vessel.
- While there are other drugs and suppliers of devices for removal of blockages, there remains a need for methods and devices that improve the success rate and/or reduce the complication rate in restoring flow and thereby limit the damage from an ischemic stroke.
- It should be noted that the present methods and devices may be sued to treat blockages leading to ischemic stroke as well as to treat blockages (caused by “obstructions”) within other parts of the body (i.e., unless specifically noted, the devices and methods are not simply limited to the cerebral vasculature). The term obstructions may include blood clot, plaque, cholesterol, thrombus, naturally occurring foreign bodies (i.e., a part of the body that is lodged within the lumen), a non-naturally occurring foreign body (i.e., a portion of a medical device or other non-naturally occurring substance lodged within the lumen).
- In one variation of the devices described herein, the device allows for surrounding the obstruction prior to attempting to translate or move the obstruction within the vessel. It should be noted that although minimal axial movement of the obstruction may take place, the device surrounds the obstruction before such movement causes significant distortion to the geometry of the obstruction resulting in an increase in the static force required to remove the obstruction from the vessel.
- In another variation of the device, the device may include a low friction ode (such as a set of parallel wires, or wires extending axially along the lumen or vessel) that converts to an increased friction mode (such as a compressed set of wires acting on the obstruction or a twisted set of wires acting on the obstruction). The increase in friction is an increase in the friction between the obstruction and the device (as opposed to the vessel wall. In some cases, the low friction modes is a low surface area mode and the high friction mode is a high surface area mode. When configured in the low friction mode, the device is better suited to engage the obstruction without the undesirable effect of prematurely mobilizing the obstruction or compacting the obstruction (e.g., when wires are slid across the obstruction in a transverse motion). Upon engaging the obstruction, the device will conform to a high friction mode with respect to the obstruction (in some cases the device will have an increased surface area mode). This high friction mode permits the device to better grip the obstruction for ultimate removal of the obstruction.
- The operation of the devices and method described herein secure the obstruction, overcome the elastic forces of the obstruction, then remove the obstruction from the anatomy without losing or fractionating the obstruction. In one variation of the invention, this is accomplished by the obstruction removal device interacting with the obstruction in the following manner: (1) the traversing filaments traverse the obstruction by passing either through the obstruction or between the obstruction and the vascular wall; (2) the traversing portion is pulled proximally to engage the surrounding portion of the device around the obstruction, the surrounding portion engaging the obstruction without causing significant mobilization of the obstruction; (3) the obstruction removal device is pulled further proximally and the surrounding portion now mobilizes the obstruction.
- As shown below, variations of the devices have a configuration that provides a path for a portion of the device to surround the obstruction. The paths are made using traversing filaments that allow for low frictional translation of a surrounding portion of the device over the obstruction without causing axial translation of the obstruction. This mechanism is described in more detail below.
- Once in the proper position, a portion of the device (e.g., a surrounding portion) increases the frictional contact with the obstruction to disperse the pulling force more evenly across the obstruction. The increase points of contact allow for removal of the obstruction through tortuous anatomy while ensuring that the obstruction will not escape the encapsulation.
- The surrounding portion may be fabricated in a variety of ways. For example, the surrounding portion may comprise one or more filaments. The surrounding portion may comprise a filter/bag, a coil, helical filament, a mesh structure, corrugated sheet, braided filaments, single wound or crossing filaments, tubes, membranes, films, solid wires, filled tubes, castings. Furthermore, the surrounding portion may have one or more ports, openings, slits, and/or holes. The surrounding portion may be made by photochemical etching, mechanical drilling, weaving, braiding, laser cutting, or other means.
- It should be noted that reference to surrounding or securing the obstruction includes partially and/or fully surrounding, engulfing, encapsulating, and/or securing the obstruction. In any case, the surrounding portion engages the obstruction prior to translation of the obstruction within the lumen. As noted herein, a portion of the device may convert into a surrounding section (e.g., when traversing wires reorient to increase the friction acting on the obstruction). Accordingly, the traversing section converts into a surrounding section.
- The various devices described herein rely on a reduced profile for delivery and an expanded profile for ultimate removal of the clot. The devices, or components of the devices, may expand when released from a constraint, which allows the device, or component, to assume a predetermined shape. Alternatively, or in combination, the devices may be actuated to assume the expanded profiles. For example, the devices may be shape memory alloys that assume a profile when reaching a predetermined temperature (e.g., body temperature, or another temperature via delivery of energy to the shape memory alloy to trigger a phase change). Actuation may also include use any expandable member (such as a coiled spring, balloon, wedge, etc.) that mechanically or fluidly forces expansion of the device. These modes are well known by those skilled in the art and are intended to be within the scope of the disclosure. When combined with the inventive concepts disclosed herein, such combinations fall within the inventive scope of this disclosure.
- As noted above, the filaments of the invention may be sued to translate the device or may be used to form the surrounding section. Accordingly, the filaments may be single wound or crossing filaments, tubes, membranes, films, solid wires, filled tubes, castings or any similar structure. Moreover, the cross section of such filaments may vary as required (e.g., circular, oval, rectangular, square, or any such shape.) The filaments may be constructed from metals, polymers, composites, hydrogels, membranes, shape memory metals, shape memory polymers, or shape memory alloys, superelastic metals, superelastic polymers, or superelastic alloys, or combinations thereof. The filaments may have uniform diameters or varying diameters. The characteristics of the filament may be selected to better suit their required function. For example, they can be stiff, floppy, or even have different zones of flexibility. Moreover, the filaments may be braided or woven members, or the construction may provide that the filaments cross at one or many points in an overlapping, interwoven, criss-crossing or similar manner.
- It should be noted that in some variations of the invention, all or some of the filaments (used in the surrounding portion of the device) can be designed to increase their ability to adhere to the obstruction. For example, the filaments of the surrounding portion may be coupled to an energy source (e.g., RF, ultrasonic, or thermal energy) to “weld” to the obstruction. Application of energy to the filaments may allow the surrounding portion to deform into the obstruction and “embed” within the obstruction. Alternatively, the filaments may impart a positive charge to the obstruction to partially liquefy the obstruction sufficiently to allow for easier removal. Alternatively, a negative charge could be applied to further build thombus and nest the device for better pulling force. The filaments may be made stickier by use of a hydrophilic substance(s), or by chemicals that would generate a chemical bond to the surface of the obstruction. Alternatively, the filaments may reduce the temperature of the obstruction to congeal or adhere to the obstruction.
- Each of the following figures diagrammatically illustrates aspects of the invention. Variation of the invention form the aspects shown in the figures is contemplated.
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FIG. 1 illustrates a system for removing obstructions from body lumens. -
FIG. 2A illustrates an example of an obstruction lodged within a body lumen. -
FIGS. 2B to 2F illustrate advancement of a catheter beyond an obstruction and placement of traversing wires around the obstruction. -
FIG. 3A illustrates an obstruction removal device once converted to a high friction mode. -
FIGS. 3B to 3E, show variations of a device having filaments that do not cross one another over the length of the obstruction when converted to a high friction mode. -
FIGS. 3F to 3G illustrate positioning a surrounding portion and translating the surrounding portion over the obstruction. -
FIGS. 3H to 3I illustrate an obstruction removal device deployed distally to an obstruction and then translated proximally over the obstruction. -
FIGS. 4A to 4E illustrate various additional configurations of devices able to assume a high friction mode covering over an obstruction. -
FIG. 4F illustrates a variation of a device using an end of a catheter for converting the device to a high friction mode. -
FIGS. 5A to 5B illustrate another variation of a portion of an obstruction removal device configured to convert from a low friction mode to a high friction mode. -
FIGS. 6A to 6G illustrate various configurations of connectors for use with obstruction removal devices. -
FIGS. 6H to 6I illustrate a variation of a leading wire and connector having an unconstrained shape that is selected to be larger or simply different than the intended vessel to provide increased stability upon deployment. -
FIG. 7A to 7D illustrates variations in which the connector is offset. -
FIGS. 8A to 8B illustrate hooks, fibers, and/or barbs for increasing the ability of the device to remove obstructions. -
FIGS. 9A to 9C illustrate additional variations of obstruction removal devices. -
FIGS. 10A to 10H also illustrate additional variations of obstruction removal devices, focusing mainly on variations of the surrounding portion. -
FIGS. 11A to 11C illustrate a variation where use of mechanical expansion distends the vessel wall and loosens the obstruction from the vessel. - It is understood that the examples below discuss uses in the cerebral vasculature (namely the arteries). However, unless specifically noted, variations of the device and method are not limited to use in the cerebral vasculature. Instead, the invention may have applicability in various parts of the body. Moreover, the invention may be used in various procedures where the benefits of the method and/or device are desired.
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FIG. 1 illustrates asystem 10 for removing obstructions from body lumens as described herein. In the illustrated example, this variation of thesystem 10 is suited for removal of an obstruction in the cerebral vasculature. Typically, thesystem 10 includes acatheter 12 microcatheter, sheath, guide-catheter, or simple tube/sheath configuration for delivery of the obstruction removal device to the target anatomy. The catheter should be sufficient to deliver the device as discussed below. Thecatheter 12 may optionally include aninflatable balloon 18 for temporarily blocking blood flow or for expanding the vessel to release the obstruction. - It is noted that any number of catheters or microcatheters maybe used to locate the catheter/
microcatheter 12 carrying the obstruction removal device (not illustrated) at the desired target site. Such techniques are well understood standard interventional catheterization techniques. Furthermore, thecatheter 12 may be coupled to auxiliary or support components 14, 16 (e.g., energy controllers, power supplies, actuators for movement of the device(s), vacuum sources, inflation sources, sources for therapeutic substances, pressure monitoring, flow monitoring, various bio-chemical sensors, bio-chemical substance, etc.) Again, such components are within the scope of thesystem 10 described herein. - In addition, devices of the present invention may be packaged in keys including the components discussed above along with guiding catheters, various devices that assist in the stabilization or removal or the obstruction (e.g., proximal-assist devices that holds the proximal end of the obstruction in place preventing it from straying during removal or assisting in the removal of the obstruction), balloon-tipped guide catheters, dilators, etc.
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FIGS. 2A to 2F show one example of the deployment of the basic structure of connectors and traversing filaments about an obstruction in a vessel. The figures are intended to demonstrate the initial placement of the connectors and filaments immediately prior to removal of the obstruction either using a filter or by torquing, rotating and/or twisting the near connector relative to the far connector. This action converts the device from a low friction device to a high friction device (where the low/high friction is the friction between the device and the obstruction). This action may also be referred to as a low surface area mode converting to a high surface area mode (in cases where the device extends beyond the obstruction and relative motion between ends of the device causes the device to shrink in axial length as it is twisted.) In addition, the number of connectors used, the shape of the connectors, as well as the number of filaments is intended to be for illustrative purposes only. It is contemplated that any variation of connector and/or filament may be deployed in a similar manner. -
FIG. 2A illustrates an example of anobstruction 2 lodged within a body lumen orvessel 6. In the case where the vessel is a cerebral artery, the obstruction may result in an ischemic stroke. Using standard interventional catheterization techniques, amicrocatheter 102 and guidewire 104 traverse the obstruction. Themicrocatheter 102 may be advanced through theobstruction 2. Alternatively, themicrocatheter 102 may “push” aside the obstruction and is advanced around the obstruction. In any case, themicrocatheter 102 travels from the near end 3 (or proximal side) of theobstruction 2 to the far end 4 (or distal side) of theobstruction 2. It is noted that thecatheter 102 may be centered or off-center with respect to theobstruction 2. Furthermore, the device may or may not be used with a guidewire to navigate to the site and traverse the obstruction. -
FIG. 2B shows another variation where amicrocatheter 102 traverses theobstruction 2 between the wall of thevessel 6 and theobstruction 2. As shown, the open end of themicrocatheter 102 is distal to theobstruction 2 and is now positioned to deploy devices for removal of theobstruction 2. This variation shows the device after removal of any guidewire. However, some variations of the device may be placed without an accompanying guidewire. Moreover, the structures discussed herein may be directly incorporated into a guidewire assembly where deployment may require a sheath or other covering to release the components from constraint. -
FIG. 2C illustrates deployment of afar connector 110 from within themicrocatheter 102 distal to theobstruction 2. Thefar connector 110 can be self-expanding such that it assumes, or moves towards, the expanded profile (as shown) upon deployment from the constraint of themicrocatheter 102. - The
connectors filaments 112 are designed to expand to the wall of the vessel when released from the catheter. This action allows thedevice 100 to surround theobstruction 2 prior to attempting to dislodge it. The components of the obstruction removal device 100 (e.g., the leadingwires 106, theconnectors filaments 112, and/or the surrounding portion 114) may be fabricated from any biocompatible material that permits the function as described herein. In some variations, that material may comprise a shape memory or super-elastic alloy such as nitinol. -
FIG. 2D shows withdrawal of themicrocatheter 102 to theproximal side 3 of theobstruction 2. The spacing between thefar connector 110 and theobstruction 2 may vary. In some cases, thefar connector 110 will move closer towards theobstruction 2 during spacing of the traversingfilaments 112 as discussed below. Thefar connector 110 remains in place either using the inherent friction of the connector against the vessels and/orobstruction 2. Alternatively, or in combination, a wire-type member (not shown) may provide an opposing force against theconnector 110 as thecatheter 102 moves proximal to theobstruction 2. - As discussed herein, the obstruction removal devices include a plurality of filaments affixed between connectors. Since the
far connector 110 is deployed at the distal side 4 of theobstruction 2, withdrawal of themicrocatheter 102 results in the plurality offilaments 112 spanning across theobstruction 2 as shown. -
FIG. 2E illustrates deployment of anear connector 108. Although the illustrated variation depicts thenear connector 108 as being deployed from within themicrocatheter 102, alternative variations of the device include anear connector 108 that is located about the exterior of themicrocatheter 102 or that is located about another delivery device (not shown) that is external to themicrocatheter 102. In this case, thenear connector 108 is similar in profile and design to thefar connector 110. Accordingly, thenear connector 108 self expands within thevessel 6 upon deployment from themicrocatheter 102. In some variations of the device, the near andfar connectors obstruction 2. -
FIG. 2E also illustrates a connecting or leading wire/member 106 that couples themicrocatheter 102 to thenear connector 108. The term leading wire, leading member, lead wire, etc. is intended to encompass a wire, tube, or any other structure that organizes and sometimes houses the smaller traversing filaments and/or near connectors described herein. Naturally, variations of the device include aleading wire 106 that is affixed to the far connector or the traversing wires. Moreover, the illustration depicts a singleleading wire 106. However, as noted below, the device can include a number oftraversing wire 106 affixed to the near and/orfar connectors -
FIG. 2F illustrates spacing the traversing filaments/wires 112 from simply spanning the obstruction 2 (as depicted inFIG. 2E ). This action causes thefilaments 112 to span theobstruction 2 while reorienting towards an exterior of theobstruction 2. As noted herein, the traversingfilaments 112 may remain partially or fully within theobstruction 2. However, given that the filaments are spaced about the connectors, the filaments shall separate radially over the obstruction allowing for the subsequent ensnaring and removal. - Spacing the filaments may occur via a number of modes such as tensioning, expanding, spreading separating and/or withdrawing the filaments. In certain variations of the device, the filaments are moveable relative to a near connector and/or a far connector. Such a feature allows application of tension to the filaments while keeping the connector in place. This causes the filament to enter a state of tension for spacing about the wall of the vessel. Alternatively, the filaments may be fixed relative to the connectors. Upon deployment the filaments either self expand or are actuated to space about the vessel wall for eventual translation of the device over the obstruction. Regardless of the mode used, the filaments are intended to be positioned at or near a surface of the obstruction so that they can reduce the effects of any friction between the obstruction and the lumen or vessel wall.
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FIGS. 3A to 3I provide illustrations of device variations that ensnare theobstruction 2 after the device is in the configuration demonstrated byFIG. 2F above.FIGS. 3A, 3C , and 3E represent variations of thedevice 100 after transforming from a low friction mode to a higher friction mode for removal of the obstruction.FIGS. 3F and 3G illustrate a variation where a surrounding portion of filter covers the obstruction for its ultimate removal from the body. -
FIG. 3A illustrates rotation of thenear connector 108 relative to thefar connector 110 to ensnare theobstruction 2 within the traversingwires 112. As noted herein, either connector may rotate while another connector remains stationary. Alternatively, each connector may rotate with the rate of rotation for one connector being slower than another. In yet another variation, each connector may be rotated in opposite directions. - Although the variation shows only four traversing
wires 112 any number of wires may be used so long as the rotation converts the traversingwires 112 into a relatively increased friction mode as compared to the low friction mode (when the traversing wires are in a parallel configuration). The low friction mode is represented byFIG. 2F .FIG. 3A illustrates theobstruction removal device 100 after rotation of the sets of traversing filaments and connectors. The result is that theobstruction 2 becomes ensnared (and/or encapsulated) and may be removed from the body. It should be noted that the same effect may be achieved by only rotating one connector or set of wires while keeping the other connector or set of wires stationary. - The rotation of the
connector 108 can be performed in any number of ways as known to those skilled in the art. However, as shown inFIG. 3A , thelead wire 106 may comprise additional secondary wires attached to theconnector 108. So rotation of theconnector 108 may occur via rotation of the lead wire and/or microcatheter. In any case, once the device assumes the increased friction mode condition, theobstruction 2 can be moved laterally within the vessel for removal. -
FIGS. 3A to 3E illustrate various configurations where relative rotation of theconnectors FIG. 3A , the traversingfilaments 112 twist and cross one another over the length of theobstruction 2. However, as shown inFIGS. 3B to 3E, variations of thedevice 100 can havefilaments 112 that do not cross one another over the length of theobstruction 2. Although these variations are depicted to have single connectors on each end and four filaments, the design of the devices may vary as required by the particular application. In addition, the variations shown inFIG. 3B to 3E are shown without any catheter or leading wire for convenience to better illustrate the conversion of the device from a low friction mode to a high friction mode. Naturally, rotation of the catheter and/or lead wire will cause relative rotation between connectors. - In
FIG. 3B , thedevice 100 is in a similar position as that shown inFIG. 2E . However,FIG. 3B shows a variation of adevice 100 that is is selected to have a length greater than the targetedobstruction 2. Upon rotation, the traversingfilaments 112 remain uncrossed over the length of theobstruction 2. In some cases, thefilaments 112 may experience some twisting and will not remain parallel. However, thefilaments 112 twist at twist points 116 that are proximal to and distal to theobstruction 2. The relative motion of theconnectors twist point 116 causes thefilaments 112 to exert a compressive force on theobstruction 2 without crossing one another over the length of the construction. Accordingly, while the surface area in contact between thefilaments 112 andobstruction 2 remains relatively the same, the compressive action of thefilaments 112 onto the obstruction converts thedevice 100 to a high friction mode on the obstruction. -
FIG. 3D illustrates another variation of a device in a similar position as that shown inFIG. 2E . However,FIG. 3D shows a variation of adevice 100 that extends proximally from the near end of theobstruction 2. The relative motion betweenconnectors twist point 116 that is proximal to theobstruction 2. As with the previous variation, thetwist point 116 forces thefilaments 112 against theobstruction 2 without crossing one another over the length of theobstruction 2. As a result, thedevice 100 is now in high friction mode. In some cases, thefilaments 12 may experience some twisting and will not remain parallel. - The variation of
FIGS. 3D to 3E also show thedevice 100 as including a cap or cover 118 about thedistal connector 110. The cap or cover 118 may be a bag, mesh, a continuation of thefilaments 112, and/or a surroundingportion 114 as discussed herein. The cap or cover 118 reduces the likelihood that the obstruction is driven through thefar connector 110 during conversion of thedevice 100 from a low friction mode to a high friction mode. -
FIG. 3F illustrates another variation of a device where thefar connector 110 includes a filter or surroundingportion 114. In variations of the device, thefilter 114 is sufficiently permeable to allow blood flow therethrough. As noted above, the surroundingportion 114 may be any structure that covers, encapsulates, engulfs, and/or ensnares the obstruction either fully or partially. Accordingly, although the surroundingportion 114 is illustrated as a filter/bag, the surroundingportion 114 may comprise a coil, helical wire, a plurality of filaments, mesh structure, corrugated sheet, braided filaments, single wound or crossing filaments, tubes, filled tubes, castings, solid wires, membranes, films, capturing sections, (and may include ports, openings, slits, and/or holes made from photochemical etching, mechanical drilling) or any other structure that may translate or remove theobstruction 2 once the frictional component is addressed. - In this variation, the
obstruction removal device 100 includes leadingfilaments 106 connected to anear connector 108. In this example, thelead filament 106 may be a single wire or filament. Alteratively, the lead filament may comprise a single wire with a plurality of wires connecting the single wire to the ring. - As with the above examples, the illustrated variation shows the
connector 108 as comprising a loop. However, as described herein, the connectors may also comprise various alternate shapes (e.g., a circle, an arcuate shape, a partial circular shape, a loop, an oval, a square, a rectangle, a polygon, an overlapping loop, a pair of semi-circles, a flower shape, and a figure 8, other shapes, etc.) Thenear connector 108 is joined to afar connector 110 via a plurality offilaments 112. It is noted that the inventive device shall include at least one, but preferably two ormore traversing filaments 112. It is further noted that theobstruction removal device 100 may be part of or integrated with themicrocatheter 102. -
FIG. 3G illustrates withdrawal of themicrocatheter 102 and the proximal translation ofdevice 100 to place the surroundingportion 114 over theobstruction 2. As theobstruction removal device 100 translates proximally, the traversingfilaments 112 locate towards the exterior region of theobstruction 2. As discussed above, theconnectors filaments 112 are designed to expand to (or near to) the perimeter of the wall of thevessel 2 and will usually locate to an exterior of theobstruction 2. However, variations of the device and method include situations where the filaments locate substantially, but not fully, towards the outer region of the obstruction. In any case, the location of thefilaments 112 will sufficiently overcome the frictional forces discussed herein. In the illustrated variation, the traversingfilaments 112 substantially span the length of theobstruction 2 by extending across the (proximal) 3 and (distal) 4 sides. These traversingfilaments 112 provide paths for movement of thedevice 100 around theobstruction 2. These paths allow for the surroundingportion 114 to engulf theentire obstruction 2 so that it may be removed from the vasculature and body. -
FIG. 3H depicts anobstruction removal device 100 similar to that shown inFIG. 3F . However, in this variation, the near andfar connectors obstruction 2 and then translated back over theobstruction 2. As shown, this deployment allows the traversingfilaments 112 and the surroundingportion 114 to separate prior to contacting theocclusion 2. Next, theentire device 100 is pulled over theocclusion 2 as described above. The variation of the device shown inFIGS. 3F and 3H addresses the frictional forces that act between the obstruction and the vessel wall. Conventional devices that provide a bag attached to a wire (such as a vascular filter or distal protection device), are typically unable to remove the obstruction because they cannot overcome these frictional forces that lodge the clot against the vessel wall. Typically, such conventional devices are only designed to “catch” free floating clots. The traversing filaments described herein are configured to be positioned surrounding the obstruction. Their low friction with respect to the clot and the vessel allows for positioning of the filaments without disrupting or further compacting the clot against the vessel wall. Once the filaments surround or are spaced about the obstruction, they reduce the friction between the clot and vessel wall by reducing points of contact. Once these filaments surrounded the clot, they permit translation of the device to permit anencapsulating section 114 to surround the obstruction for removal. -
FIG. 3I illustrates thedevice 100 ofFIG. 3H when translated over theobstruction 2. Eventually, thedevice 100 is pulled so that the surrounding portion or bloodpermeable filter 114 covers the obstruction 2 (as shown inFIGS. 3F and 3G . -
FIG. 4A illustrates another variation of a portion of anobstruction removal device 120 that is able to convert from a low friction mode covering to a higher friction mode covering. As noted above, this variation allows the medical practitioner to engage an obstruction with sparse coverage or low friction mode to overcome frictional forces. Upon properly engaging the obstruction, the device configuration allows conversion to a high friction mode for removal of the device and obstruction. - As shown, this variation of the
obstruction removal device 120 includes two sets of traversingfilaments connectors first set 122 comprises a firstnear connector 108 and firstfar connector 110 with the accompanying traversing filaments. Thesecond set 124 comprises the secondnear connector 126 and secondfar connector 128 with the accompanying traversingfilaments 124. Thesecond set 124 is coaxially located over thefirst set 122. The materials of the components may be as described above. In any case, the components are designed to expand to the perimeter of the vessel wall upon release from the catheter. -
FIG. 4B shows the conversion of the obstruction removal device converting from a low friction mode (fromFIG. 4A ) to the high friction mode. For example, the firstnear connector 108 may be rotated relative to the second near connector 126 (where the second near connector may remain still or it may be rotated in an opposite direction relative to the first near connector as shown by the arrows). As a result, the traversingfilaments -
FIG. 4C illustrates another variation of anobstruction removal device 100 in a low friction mode state. In this variation, thedevice 100 includes anear connector 108, afar connector 110 with traversing filaments between theconnectors device 100 also includes anadditional connector 132 withnon-rotating filaments 134 extending to thefar connector 110.FIG. 4D illustrates thedevice 100 ofFIG. 4C when thenear connector 108 is rotated as shown byarrow 136. However, theadditional connector 132 and associatedfilaments 134 do not rotate. Upon rotation of thenear connector 108 and twisting of thefilaments 112, all of thefilaments -
FIG. 4E shows another variation of anobstruction removal device 100 configured to move between low and high friction mode states. This variation includes additional support rings 138 located betweenconnectors filaments 112. The support rings keep thedevice 100 at a relatively constant diameter upon assuming the increased friction mode state. The support rings may be slightly undersized compared to the connectors, allowing the filaments to slightly compress the obstruction when converted to a high friction mode, but limiting the amount of compression by limiting the resulting diameter. The support rings 138 can be freely placed within the traversingfilaments 112. Alternatively, therings 138 can be attached to one or more than onefilament 112 to prevent undesired migration during deployment of the device. -
FIG. 4F illustrates one example of amicrocatheter 102 having anear connector 108 located externally to thecatheter 102 with traversingfilaments 112 extending out of the catheter and through theconnector 108. In this variation, rotation or torquing of thecatheter 102 twists thefilaments 112 resulting in increased friction mode of thefilaments 112 over an obstruction.FIG. 4F illustrates anadditional connector 132 havingstationary filaments 134. This variation of the device includes theexternal connector 108 directly coupled to a far connector (not shown.) -
FIG. 5A illustrates a variation of thedevice 120 having onlyconnectors 108 at one side of thedevice 120. In this variation, thedevice 120 may still include twosets filaments FIG. 5B illustrates the variation ofFIG. 5A after conversion to a high friction mode over theobstruction 2. As discussed herein, the connectors may be other structures than loops. Moreover, variations of the invention include connectors that may be drawn down to a smaller size to facilitate removal from the body after securing the obstruction. This may be accomplished by torquing the device or part thereof, by re-sheathing part or all of the device, or by any mechanical means designed into the features of the device itself. Any of these actions, or combination thereof, may also serve to compress or decrease the diameter of the obstruction itself to facilitate removal from the body. - In another variation, the devices described herein may be assembled or constructed in-situ. For example, components of the device may include connectors, portions of the connectors, traversing elements, and/or surrounding sections. Any combination of these components can be placed in sequential fashion. Doing so forms a completed structure from deployment of a number of individual components. The end result is the formation of a device as shown in the figures. Accordingly, such components of the device may be separately deployed in a manner that requires “assembly” of the components by a medical practitioner during the procedure.
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FIGS. 6A-6G illustrate variations of theconnectors FIG. 6A shows a loop-shapedconnector -
FIG. 6A also illustrates the connector as having attachment points 140 for coupling the filaments to the connectors. These attachment points may allow for movement of the filaments relative to the connector to tension or separate the connectors (as described above.) The filaments may also be coupled such that they are fixed relative to the connectors. In such a case, pulling of the lead wire will cause the entire assembly (e.g., connectors, filaments, and/o surrounding portion) to translate through the vessel. -
FIGS. 6B through 6G show various configurations of connectors for use in the present device. The connectors may be cut from sheets, fabricated from wire, molded, stamped, laser cut, photo or chemically etched, or fabricated in any other customary manner. Moreover, theconnectors FIGS. 6B to 6E are shown without any accompanying traversing filaments. -
FIG. 6B shows aconnector FIG. 6C and an overlapping profile, as illustrated inFIG. 6D . Such constructions allows the connector to adjust to varying diameters of body lumens. It is noted that a device may comprise loops of either construction. It should be also noted that although loops are shown, other variations may work equally well. Variations of the invention include connectors that may be drawn down to a smaller size to facilitate removal from the body once the obstruction is secured. This may be accomplished by torquing the device or part thereof, by re-sheathing part or all of the device or by any mechanical means designed into the features of the device itself. Any of these actions, or combination thereof, may also serve to compress or decrease the diameter of the obstruction itself to facilitate removal from the body. In addition, the overlapping connector, as shown inFIG. 6D , may include a sliding ring type fastener that allows the overlapping connector loop to expand in the same plane. - In another example, the device may be fabricated from a polymer composite that makes up the fasteners, filaments, bags, etc. where the polymeric composite is very floppy until it is exposed to either the body fluids and or some other delivered activator that causes the polymer to further polymerize or stiffen for strength. Various coatings could protect the polymer from further polymerizing before the device is properly placed. The coatings could provide a specific duration for placement (e.g., 5 minutes) after which the covering degrades or is activated with an agent (that doesn't affect the surrounding tissues) allowing the device to increase in stiffness so that it doesn't stretch as the thrombus is pulled out. For example, shape memory polymers would allow the device to increase in stiffness.
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FIG. 6E shows aconnector multiple sections 146. As noted above, theconnector sections 146 are arcuate shaped to minimize trauma to a vessel wall. However, other shapes are also intended to be within the scope of this disclosure. -
FIGS. 6B through 6G also illustrate various configurations of leadingwires 106. The connectors may have any number of leading wires. In some variations, it may be desirable to space the leading wires about the profile of the connector to aid in uniform movement of the device as it is pulled over the obstruction in the vessel. -
FIGS. 6F and 6G illustrate additional variations of leadingwires 106 comprising shaped wire structures that form a “c”portion 142 of the connector. In one variation, when constrained the “c” shapedportions 142 move together to allow for delivery within the catheter. Upon release from the catheter, theportions 142 assume their resting shape and expand within the vessel. The connectingportions 142 can be selected to have a size that is slightly greater than that of the vessel. Sizing the device relative to the target vessel may assist in placing the connectingportions 142 and accompanying traversingwires 112 against the wall of the vessel. -
FIG. 6G shows an additional variation where aportion 144 of aleading wire 106 also has a “c” or semi-circular shape. In this configuration, the “c” shapedportion 144 of theleading wire 106 can also be sized relative to the target vessel. Accordingly, theportion 144 of theleading wire 106 functions to drive the connectingportion 142 against the vessel wall, while the shape of the connectingportion 142 also drives thetraversing wire 112 against the vessel wall. -
FIG. 6H illustrates another variation of aleading wire 106 having an unconstrained shape that is selected to be larger than the intended vessel or simply different than a cross sectional profile of the intended vessel (i.e., not circular or tubular, but e.g., linear or other different shape). In this variation, the leadingwire 106 hasportions 144 that extend in opposite directions. This configuration is intended for illustrative purposes only. Variations include connecting portions pointing in an orthogonal direction from themain lead wire 106, oblique, parallel (as shown), or a combination thereof. In any case, the unconstrained shape is intended to have a larger profile or size than the intended vessel. Moreover, the unconstrained shape may have an entirely different profile than the intended vessel. As shown in the figures, the profile of the device extends radially from the vessel. So when the device and leading wire are released, the leading wire attempts to return to the unconstrained shape. In those variations where the unconstrained shape is different from the circular profile of the vessel, the leading wire assumes a shape that accommodates the vessel but is more rigid and stable since its unconstrained shape is entirely different from that of the vessel. -
FIG. 6I shows the same device ofFIG. 6H when released from a microcatheter, sheath, or tube when in the vessel. Once released, the leadingwire 106 and accompanyingportions 144 attempt to revert to the unconstrained shape (as shown inFIG. 6H ). However, thevessel 6 restrains theleading wire 106 andportions 144 such that theportions 144 act on the walls of the vessel. This feature allows for improved stability when deploying the leading wires and attached connectors and filaments within the vessel. -
FIGS. 7A through 7C illustrate variations ofconnectors connector portions FIG. 7A illustrates an offset 152 betweenconnector portions 142 where eachportion 142 is coupled to leadingwires FIG. 7B illustratesconnector portions 146 spaced axially along aleading wire 106 to provide agap 152.FIG. 7C illustrates aconnector multiple components 146 where one or more components is axially spaced to provide agap 152.FIG. 7D shows avariation connector portion 146 is non-planar such that thegap 152 occurs over the length of theconnector portion 146. - Another aspect applicable to all variations of the devices is to configure the devices (whether the traversing filament or the surrounding portion) for better adherence to the obstruction. One such mode includes the use of coatings that bond to certain clots (or other materials causing the obstruction.) For example, the traversing filament and/or surrounding portion may be coated with a hydrogel or adhesive that bonds to a thrombus. Accordingly, as the surrounding portion covers the clot, or as the device twists about the clot, the combination of the additive and the mechanical structure of the device may improve the effectiveness of the device in removing the obstruction.
- Such improvements may also be mechanical or structural. For example, as shown in
FIG. 8A , the traversing members may have hooks, fibers, orbarbs 154 that grip into the obstruction when the device converts to a high friction mode. The hooks, fibers, orbarbs 154 may also be incorporated into the surrounding portion. However, it will be important that such features do not hinder the ability of the practitioner to remove the device from the body. For example,FIG. 8B illustrates a magnified view of thearea 8B fromFIG. 8A . As illustrated, the barbs may be configured such that rotation in a particular direction causes the barbs to adhere to the obstruction. Such a configuration could also allow lateral movement without the barbs interfering with the vessel. - In addition to additives, the device can be coupled to an RF or other power source (such as 14 or 16 in
FIG. 1 ), to allow current, ultrasound or RF energy to transmit through the device and induce clotting or cause additional coagulation of a clot or other the obstruction. - The methods described herein may also include treating the obstruction prior to attempting to remove the obstruction. Such a treatment can include applying a chemical or pharmaceutical agent with the goal of making the occlusion shrink or to make it more rigid for easier removal. Such agents include, but are not limited to chemotherapy drugs, or solutions, a mild formalin, or aldehyde solution.
- Although not illustrated, the devices and methods described herein may also be useful in removing obstructions lodged within bifurcations in the anatomy. Generally, bifurcations greatly increase the frictional forces on the obstructions since the obstruction tends to be lodged in both branching sections of the bifurcation. In such cases, the use of the presently described devices and methods may also include an additional “puller” device that advances beyond the portion of the obstruction partially located in the bifurcated vessel.
- As for other details of the present invention, materials and manufacturing techniques may be employed as within the level of those with skill in the relevant art. The same may hold true with respect to method-based aspects of the invention in terms of additional acts that are commonly or logically employed. In addition, though the invention has been described in reference to several examples, optionally incorporating various features, the invention is not to be limited to that which is described or indicated as contemplated with respect to each variation of the invention.
-
FIGS. 9A through 9C illustrate additional variations of obstruction removal devices. In these variations, the traversingfilaments 112 may comprise a mesh of wires or single connector.FIGS. 9A to 9B illustrate a variation in which theconnector 108 comprises a wire rather than a loop. However, the filaments and connectors should be configured to expand to the perimeter of the vessel wall as described previously. -
FIGS. 10A-10H illustrate various additional embodiments ofobstruction removal devices 130 according to the present invention. In these variations, theconnector 108 may form a rigid wire or hard polymer to assist in placement of thedevice 130. The surroundingportion 132 may be fabricated from less rigid filaments that increase the point of contact with the obstruction. The surrounding portion may also have filaments that undergo a phase change from non-rigid (or less rigid) or rigid. - It should be noted that any number of traversing
filaments 112 or sets may be used in these variations. - In additional aspect of the invention, as shown in
FIG. 11A to 11C, the methods and or devices may include expansion of the vessel wall adjacent to the obstruction either with a balloon, coil, or similar mechanical expansion means, drugs, fluids, etc. Such an improvement may aid where the obstruction expands part of the vessel wall thereby increasing the amount of force required for displacement. By distending the vessel wall as described above, the forces on the obstruction may be reduced allowing for ease of removal.FIG. 11A illustrates anobstruction 2 embedded within thevessel 6.FIGS. 11B to 11C illustrate variations where use of a coil (FIG. 11B ) or a non-distensible balloon 162 (FIG. 11C ) proximal to theobstruction 2 distends the vessel wall to loosen theobstruction 2 from the vessel. Accordingly, devices (whether described herein or other conventional devices) may then remove theobstruction 2. - In those variations with a mechanical expansion means, the expansion means may be located on the delivery catheter of the obstruction removal device, on a wire member of the device, and/or a separate catheter or wire used in combination with the first delivery catheter. However, variations of such configurations are within the scope of the invention.
- In addition, devices and methods described herein may also use balloons proximal to the obstruction to stop or slow blood flow thereby preventing the blood from dislodging part or all of the obstruction.
- Various changes may be made to the invention described and equivalents (whether recited herein or not included for the sake of some brevity) may be substituted without departing from the true spirit and scope of the invention. Also, any optional feature of the inventive variations may be set forth and claimed independently, or in combination with any one or more of the features described herein. Accordingly, the invention contemplates combinations of various aspects of the embodiments or combinations of the embodiments themselves, where possible. Reference to a singular item, includes the possibility that there are plural of the same items present. More specifically, as used herein and in the appended claims, the singular forms “a,” “and,” “said,” and “the” include plural references unless context clearly dictates otherwise.
Claims (28)
1. An intravascular apparatus for removing an obstruction from a vessel of a patient, the device comprising:
a microcatheter having a size and flexibility to navigate within a neurovascular region of the patient;
a near connector having a first expanded profile when unconstrained, such that on deployment in the vessel the near connector expands towards the first expanded profile;
a far connector being collapsible to fit within the microcatheter and having a second expanded profile when unconstrained, such that on deployment in the vessel the second connector expands towards the second expanded profile;
at least one lead filament coupling the near connector to the microcatheter; and
a plurality of traversing filaments extending between the near and far connectors, and spaced apart on each connector such that spacing the traversing filaments causes the filaments to move towards a wall of the vessel.
2. The intravascular apparatus of claim 1 , further comprising a blood permeable member affixed to the far connector, the blood permeable member being collapsible to fit within the microcatheter.
3. The intravascular apparatus of claim 2 , where the blood permeable member comprises a structure selected from the group consisting of a basket, a filter, a bag, a coil, a helical wire structure, a mesh, a corrugated sheet, a braided wires, a single wound wire, a plurality of crossing wires, a tube, a membrane, and a film.
4. The intravascular apparatus of claim 2 , further comprising a plurality of hook shaped members located on the blood permeable member.
5. The intravascular apparatus of claim 1 , further comprising a third connector located adjacent to the near connector, and a plurality of non-rotating filaments extending between the far connector and the third connector, where the first connector is rotatable relative to the far and third connectors to cause the plurality of traversing filaments to form a mesh pattern.
6. The intravascular apparatus of claim 1 , where the near and far connectors are rotatable relative to each other to cause at least a section of the plurality of filaments to cross one another.
7. The intravascular apparatus of claim 6 , where the near connector is stationary and the far connector is rotatable.
8. The intravascular apparatus of claim 6 , where the far connector is stationary and the near connector is rotatable.
9. The intravascular apparatus of claim 6 , where the far connector and the near connector are rotatable in opposite directions.
10. The intravascular apparatus of claim 1 , where the near connector comprises a shape selected from a circle, an arcuate shape, a partial circular shape, a loop, an oval, a square, a rectangle, a polygon, an overlapping loop, a pair of semi-circles, a flower shape, and a figure 8.
11. The intravascular apparatus of claim 1 , where the far connector comprises a shape selected from an arcuate shape, a partial circular shape, a loop, an oval, a square, a rectangle, a polygon, an overlapping loop, a pair of semi-circles, a flower shape, and a figure 8.
12. The intravascular apparatus of claim 1 , further comprising a plurality of hook shaped members located on at least one filament.
13. The intravascular apparatus of claim 1 , where the near connector is collapsible to fit within the microcatheter.
14. The intravascular apparatus of claim 1 , where the near connector is affixed to an exterior of the microcatheter.
15. The intravascular apparatus of claim 1 , where the near connector comprises a plurality of near connector portions.
16. The intravascular apparatus of claim 15 , where at least one of the near connector portions is axially spaced from another near connector portion.
17. The intravascular apparatus of claim 1 , where the far connector comprises a plurality of far connector portions.
18. The intravascular apparatus of claim 17 , where at least one of the far connector portions is axially spaced from another far connector portion.
19. The intravascular apparatus of claim 1 , further comprising at least one support ring within the filament.
20. The intravascular apparatus of claim 1 , where the near connector, the lead filament, and the plurality of traversing filaments, are collapsible to fit within the microcatheter and are self-expanding upon deployment from the microcatheter.
21. The intravascular apparatus of claim 1 , where the near connector, the lead filament, and the plurality of traversing filaments, are collapsible to fit within the microcatheter and are actuated to expand upon deployment from the microcatheter.
22. The intravascular apparatus of claim 1 , further comprising a balloon located on the microcatheter, where on expansion the balloon expands the vessel allowing for removal of the obstruction.
23. The intravascular apparatus of claim 1 , further comprising an expandable coil located on the microcatheter and having an expanded profile, where deployment of the coil causes expansion of the vessel allowing for removal of the obstruction.
24. The intravascular apparatus of claim 1 , where at least one of the traversing filaments is moveable relative to the near connector so that tension may be applied to the respective filament to spread the filaments.
25. The intravascular apparatus of claim 1 , where at least one of the traversing filaments is moveable relative to the far connector so that tension may be applied to the respective filament to spread the filaments.
26. The intravascular apparatus of claim 1 , where at least one of the traversing filaments is moveable relative to the near and far connectors so that tension may be applied to the respective filament to spread the filaments.
27. The intravascular apparatus of claim 1 , where the filaments are fixed relative to the near and far connectors such that axial movement of the lead wire causes axial movement of the near and far connectors and filaments.
28.-167. (canceled)
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Cited By (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070185501A1 (en) * | 2006-02-03 | 2007-08-09 | Martin Brian B | Devices for restoring blood flow within blocked vasculature |
WO2009086482A1 (en) * | 2007-12-26 | 2009-07-09 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
WO2010010545A1 (en) * | 2008-07-22 | 2010-01-28 | Neuravi Limited | Clot capture systems and associated methods |
US8298244B2 (en) | 2006-10-26 | 2012-10-30 | Tyco Healtcare Group Lp | Intracorporeal grasping device |
US20130110153A1 (en) * | 2011-10-26 | 2013-05-02 | Boston Scientific Scimed, Inc. | Extended protection embolic filter |
US20130144326A1 (en) * | 2008-07-22 | 2013-06-06 | Eamon Brady | Clot capture systems and associated methods |
US8512352B2 (en) | 2007-04-17 | 2013-08-20 | Lazarus Effect, Inc. | Complex wire formed devices |
US20130310803A1 (en) * | 2012-05-21 | 2013-11-21 | Noha, Llc | Clot Removal Device and Method of Using Same |
US8632584B2 (en) | 2002-07-19 | 2014-01-21 | Dendron Gmbh | Medical implant having a curlable matrix structure and method of use |
US8679142B2 (en) | 2008-02-22 | 2014-03-25 | Covidien Lp | Methods and apparatus for flow restoration |
US8679150B1 (en) | 2013-03-15 | 2014-03-25 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy methods |
US8690907B1 (en) | 2013-03-15 | 2014-04-08 | Insera Therapeutics, Inc. | Vascular treatment methods |
US8715316B1 (en) | 2013-07-29 | 2014-05-06 | Insera Therapeutics, Inc. | Offset vascular treatment devices |
US8795305B2 (en) | 2011-05-23 | 2014-08-05 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US8801748B2 (en) | 2010-01-22 | 2014-08-12 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US8852205B2 (en) | 2011-03-09 | 2014-10-07 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US9034007B2 (en) | 2007-09-21 | 2015-05-19 | Insera Therapeutics, Inc. | Distal embolic protection devices with a variable thickness microguidewire and methods for their use |
US9039749B2 (en) | 2010-10-01 | 2015-05-26 | Covidien Lp | Methods and apparatuses for flow restoration and implanting members in the human body |
US20150374479A1 (en) * | 2014-06-30 | 2015-12-31 | Neuravi Limited | System for removing a clot from a blood vessel |
US9254371B2 (en) | 2009-03-06 | 2016-02-09 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US9314324B2 (en) | 2013-03-15 | 2016-04-19 | Insera Therapeutics, Inc. | Vascular treatment devices and methods |
US9351749B2 (en) | 2010-10-22 | 2016-05-31 | Neuravi Limited | Clot engagement and removal system |
US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
US9445829B2 (en) | 2013-03-14 | 2016-09-20 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US9642635B2 (en) | 2013-03-13 | 2017-05-09 | Neuravi Limited | Clot removal device |
US9924958B2 (en) | 2010-07-15 | 2018-03-27 | Covidien Lp | Retrieval systems and methods for use thereof |
US10064635B2 (en) | 2007-04-17 | 2018-09-04 | Covidien Lp | Articulating retrieval devices |
US10076346B2 (en) | 2007-04-17 | 2018-09-18 | Covidien Lp | Complex wire formed devices |
US10076399B2 (en) | 2013-09-13 | 2018-09-18 | Covidien Lp | Endovascular device engagement |
US10201360B2 (en) | 2013-03-14 | 2019-02-12 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10285720B2 (en) | 2014-03-11 | 2019-05-14 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US10363054B2 (en) | 2014-11-26 | 2019-07-30 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US10390926B2 (en) | 2013-07-29 | 2019-08-27 | Insera Therapeutics, Inc. | Aspiration devices and methods |
US10413310B2 (en) | 2007-10-17 | 2019-09-17 | Covidien Lp | Restoring blood flow and clot removal during acute ischemic stroke |
US10441301B2 (en) | 2014-06-13 | 2019-10-15 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10456560B2 (en) | 2015-02-11 | 2019-10-29 | Covidien Lp | Expandable tip medical devices and methods |
US10478322B2 (en) | 2017-06-19 | 2019-11-19 | Covidien Lp | Retractor device for transforming a retrieval device from a deployed position to a delivery position |
US10575864B2 (en) | 2017-06-22 | 2020-03-03 | Covidien Lp | Securing element for resheathing an intravascular device and associated systems and methods |
US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
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Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094283A2 (en) | 2004-03-25 | 2005-10-13 | Hauser David L | Vascular filter device |
US9198687B2 (en) | 2007-10-17 | 2015-12-01 | Covidien Lp | Acute stroke revascularization/recanalization systems processes and products thereby |
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US20100174309A1 (en) * | 2008-05-19 | 2010-07-08 | Mindframe, Inc. | Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter |
LT5605B (en) * | 2007-11-28 | 2009-11-25 | Kauno technologijos universitetas, , | An ultrasound wave guide for cleaning of internal blood vessels |
US20150164630A1 (en) * | 2008-01-04 | 2015-06-18 | Eric Johnson | Filter support members |
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US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
WO2009126935A2 (en) | 2008-04-11 | 2009-10-15 | Mindframe, Inc. | Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby |
US8070694B2 (en) | 2008-07-14 | 2011-12-06 | Medtronic Vascular, Inc. | Fiber based medical devices and aspiration catheters |
US9005237B2 (en) * | 2008-08-29 | 2015-04-14 | Rapid Medical Ltd. | Device and method for clot capture |
US9034008B2 (en) | 2008-08-29 | 2015-05-19 | Rapid Medical Ltd. | Device and method involving stabilization during clot removal |
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US8758364B2 (en) | 2008-08-29 | 2014-06-24 | Rapid Medical Ltd. | Device and method for clot engagement and capture |
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EP4101399A1 (en) | 2011-08-05 | 2022-12-14 | Route 92 Medical, Inc. | System for treatment of acute ischemic stroke |
AU2012338476A1 (en) * | 2011-10-24 | 2014-05-08 | Rapid Medical Ltd. | Clot removal devices and methods |
EP3821830A1 (en) | 2012-09-24 | 2021-05-19 | Inari Medical, Inc. | Device for treating vascular occlusion |
US8784434B2 (en) | 2012-11-20 | 2014-07-22 | Inceptus Medical, Inc. | Methods and apparatus for treating embolism |
US9500038B2 (en) | 2013-02-01 | 2016-11-22 | Milwaukee Electric Tool Corporation | Auger bit with replaceable cutting bit |
US9259237B2 (en) | 2013-07-12 | 2016-02-16 | Inceptus Medical, Llc | Methods and apparatus for treating pulmonary embolism |
WO2015061365A1 (en) | 2013-10-21 | 2015-04-30 | Inceptus Medical, Llc | Methods and apparatus for treating embolism |
US9265512B2 (en) | 2013-12-23 | 2016-02-23 | Silk Road Medical, Inc. | Transcarotid neurovascular catheter |
WO2015123677A1 (en) | 2014-02-17 | 2015-08-20 | Clearflow, Inc. | Medical tube clearance device |
CN116920264A (en) | 2014-02-17 | 2023-10-24 | 科里福罗公司 | Medical tube cleaning |
US20150374391A1 (en) * | 2014-03-07 | 2015-12-31 | Inceptus Medical, Llc | Methods and apparatus for treating small vessel thromboembolisms |
US9526864B2 (en) | 2014-06-09 | 2016-12-27 | Inceptus Medical, Llc | Retraction and aspiration device for treating embolism and associated systems and methods |
US9801643B2 (en) * | 2014-09-02 | 2017-10-31 | Cook Medical Technologies Llc | Clot retrieval catheter |
JP6732769B2 (en) | 2015-02-04 | 2020-07-29 | ルート92メディカル・インコーポレイテッドRoute 92 Medical, Inc. | Rapid suction thrombectomy system and method |
US10426497B2 (en) | 2015-07-24 | 2019-10-01 | Route 92 Medical, Inc. | Anchoring delivery system and methods |
US11065019B1 (en) | 2015-02-04 | 2021-07-20 | Route 92 Medical, Inc. | Aspiration catheter systems and methods of use |
IL253851B2 (en) * | 2015-02-06 | 2023-10-01 | Rapid Medical Ltd | Systems and methods for intravascular obstruction removal |
WO2017062383A1 (en) * | 2015-10-07 | 2017-04-13 | Stryker Corporation | Multiple barrel clot removal devices |
US10342571B2 (en) | 2015-10-23 | 2019-07-09 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
CN113796927A (en) | 2015-10-23 | 2021-12-17 | 伊纳里医疗公司 | Intravascular treatment of vascular occlusions and related devices, systems, and methods |
US9700332B2 (en) | 2015-10-23 | 2017-07-11 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US10716915B2 (en) * | 2015-11-23 | 2020-07-21 | Mivi Neuroscience, Inc. | Catheter systems for applying effective suction in remote vessels and thrombectomy procedures facilitated by catheter systems |
CN109069790A (en) | 2015-12-18 | 2018-12-21 | 伊纳里医疗公司 | Catheter shaft and relevant apparatus, system and method |
US11039923B2 (en) | 2016-05-06 | 2021-06-22 | Transmural Systems Llc | Annuloplasty procedures, related devices and methods |
US11007059B2 (en) | 2016-05-06 | 2021-05-18 | Transmural Systems Llc | Annuloplasty procedures, related devices and methods |
CN113215721B (en) | 2016-10-14 | 2023-02-17 | 因赛普特斯医学有限责任公司 | Knitting machine and method of use |
WO2018080590A1 (en) | 2016-10-24 | 2018-05-03 | Inari Medical | Devices and methods for treating vascular occlusion |
EP3551107B1 (en) * | 2016-12-09 | 2023-01-18 | St. Jude Medical, Cardiology Division, Inc. | Pulmonary vein isolation balloon catheter |
EP4134120A1 (en) | 2017-01-10 | 2023-02-15 | Route 92 Medical, Inc. | Aspiration catheter systems |
JP7296317B2 (en) | 2017-02-24 | 2023-06-22 | インセプタス メディカル リミテッド ライアビリティ カンパニー | Vascular occlusion device and method |
US11234723B2 (en) | 2017-12-20 | 2022-02-01 | Mivi Neuroscience, Inc. | Suction catheter systems for applying effective aspiration in remote vessels, especially cerebral arteries |
US10478535B2 (en) * | 2017-05-24 | 2019-11-19 | Mivi Neuroscience, Inc. | Suction catheter systems for applying effective aspiration in remote vessels, especially cerebral arteries |
EP3672532B1 (en) | 2017-08-26 | 2022-08-03 | Transmural Systems LLC | Implantable cardiac pacing system |
AU2018328011B2 (en) | 2017-09-06 | 2022-09-15 | Inari Medical, Inc. | Hemostasis valves and methods of use |
WO2019075444A1 (en) | 2017-10-14 | 2019-04-18 | Inceptus Medical. Llc | Braiding machine and methods of use |
US20220104839A1 (en) | 2017-10-16 | 2022-04-07 | Retriever Medical, Inc. | Clot Removal Methods and Devices with Multiple Independently Controllable Elements |
US10258357B1 (en) | 2017-10-16 | 2019-04-16 | Michael Bruce Horowitz | Catheter based retrieval device with proximal body having axial freedom of movement |
WO2022082213A1 (en) | 2017-10-16 | 2022-04-21 | Retriever Medical, Inc. | Clot removal methods and devices with multiple independently controllable elements |
US11154314B2 (en) | 2018-01-26 | 2021-10-26 | Inari Medical, Inc. | Single insertion delivery system for treating embolism and associated systems and methods |
CN112423824B (en) | 2018-05-17 | 2023-02-21 | 92号医疗公司 | Aspiration catheter system and method of use |
AU2019321256B2 (en) | 2018-08-13 | 2023-06-22 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
CN109330661A (en) * | 2018-10-17 | 2019-02-15 | 深圳达芬奇创新科技有限公司 | A kind of blood vessel depths blood lipid rubbish medical treatment cleaning mechanism |
JP2022551992A (en) | 2019-10-16 | 2022-12-14 | イナリ メディカル, インコーポレイテッド | Systems, devices and methods for treating vascular occlusions |
US11617865B2 (en) | 2020-01-24 | 2023-04-04 | Mivi Neuroscience, Inc. | Suction catheter systems with designs allowing rapid clearing of clots |
WO2022060379A1 (en) * | 2020-09-21 | 2022-03-24 | Imcat, Inc. | Hybrid thrombectomy device and process |
CN116547031A (en) | 2020-11-17 | 2023-08-04 | 科里福罗公司 | Medical tube cleaning device |
Citations (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US2943626A (en) * | 1957-01-31 | 1960-07-05 | Dormia Enrico | Instruments for the extraction of foreign bodies |
US4807626A (en) * | 1985-02-14 | 1989-02-28 | Mcgirr Douglas B | Stone extractor and method |
US4832055A (en) * | 1988-07-08 | 1989-05-23 | Palestrant Aubrey M | Mechanically locking blood clot filter |
US5102415A (en) * | 1989-09-06 | 1992-04-07 | Guenther Rolf W | Apparatus for removing blood clots from arteries and veins |
US5192286A (en) * | 1991-07-26 | 1993-03-09 | Regents Of The University Of California | Method and device for retrieving materials from body lumens |
US5300086A (en) * | 1990-01-19 | 1994-04-05 | Pierre Gory | Device with a locating member for removably implanting a blood filter in a vein of the human body |
US5496330A (en) * | 1993-02-19 | 1996-03-05 | Boston Scientific Corporation | Surgical extractor with closely angularly spaced individual filaments |
US5509900A (en) * | 1992-03-02 | 1996-04-23 | Kirkman; Thomas R. | Apparatus and method for retaining a catheter in a blood vessel in a fixed position |
US5709704A (en) * | 1994-11-30 | 1998-01-20 | Boston Scientific Corporation | Blood clot filtering |
US5733302A (en) * | 1993-03-25 | 1998-03-31 | Hemodynamics, Inc. | Cardiovascular stent and retrieval apparatus |
US5741325A (en) * | 1993-10-01 | 1998-04-21 | Emory University | Self-expanding intraluminal composite prosthesis |
US5895398A (en) * | 1996-02-02 | 1999-04-20 | The Regents Of The University Of California | Method of using a clot capture coil |
US6033394A (en) * | 1997-12-05 | 2000-03-07 | Intratherapeutics, Inc. | Catheter support structure |
US6053932A (en) * | 1997-03-06 | 2000-04-25 | Scimed Life Systems, Inc. | Distal protection device |
US6066149A (en) * | 1997-09-30 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot treatment device with distal filter |
US6066158A (en) * | 1996-07-25 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot encasing and removal wire |
US6168603B1 (en) * | 1995-02-02 | 2001-01-02 | Boston Scientific Corporation | Surgical extractor |
US6174318B1 (en) * | 1998-04-23 | 2001-01-16 | Scimed Life Systems, Inc. | Basket with one or more moveable legs |
US6190394B1 (en) * | 1999-11-05 | 2001-02-20 | Annex Medical, Inc. | Medical retrieval basket |
US6221006B1 (en) * | 1998-02-10 | 2001-04-24 | Artemis Medical Inc. | Entrapping apparatus and method for use |
US6248113B1 (en) * | 1996-06-20 | 2001-06-19 | Ernesto Fina | Device for the electrolytic dissolution of urinary stones and related method of treatment of urinary calculosis |
US6264664B1 (en) * | 2000-03-10 | 2001-07-24 | General Science And Technology Corp. | Surgical basket devices |
US6348056B1 (en) * | 1999-08-06 | 2002-02-19 | Scimed Life Systems, Inc. | Medical retrieval device with releasable retrieval basket |
US6350266B1 (en) * | 1995-02-02 | 2002-02-26 | Scimed Life Systems, Inc. | Hybrid stone retrieval device |
US20020026211A1 (en) * | 1999-12-23 | 2002-02-28 | Farhad Khosravi | Vascular device having emboli and thrombus removal element and methods of use |
US6371971B1 (en) * | 1999-11-15 | 2002-04-16 | Scimed Life Systems, Inc. | Guidewire filter and methods of use |
US6383195B1 (en) * | 1998-04-13 | 2002-05-07 | Endoline, Inc. | Laparoscopic specimen removal apparatus |
US20020058904A1 (en) * | 2000-11-08 | 2002-05-16 | Robert Boock | Thrombus removal device |
US6402771B1 (en) * | 1999-12-23 | 2002-06-11 | Guidant Endovascular Solutions | Snare |
US6409750B1 (en) * | 1999-02-01 | 2002-06-25 | Board Of Regents, The University Of Texas System | Woven bifurcated and trifurcated stents and methods for making the same |
US6416505B1 (en) * | 1998-05-05 | 2002-07-09 | Scimed Life Systems, Inc. | Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and pressure application probe for use with same |
US6425909B1 (en) * | 1999-11-04 | 2002-07-30 | Concentric Medical, Inc. | Methods and devices for filtering fluid flow through a body structure |
US6506204B2 (en) * | 1996-01-24 | 2003-01-14 | Aga Medical Corporation | Method and apparatus for occluding aneurysms |
US20030023265A1 (en) * | 2001-07-13 | 2003-01-30 | Forber Simon John | Vascular protection system |
US6514273B1 (en) * | 2000-03-22 | 2003-02-04 | Endovascular Technologies, Inc. | Device for removal of thrombus through physiological adhesion |
US20030040771A1 (en) * | 1999-02-01 | 2003-02-27 | Hideki Hyodoh | Methods for creating woven devices |
US20030050663A1 (en) * | 2001-06-28 | 2003-03-13 | Stepan Khachin | Surgical device for retrieval of foreign objects from a body |
US20030060782A1 (en) * | 1998-06-04 | 2003-03-27 | Arani Bose | Endovascular thin film devices and methods for treating and preventing stroke |
US6540657B2 (en) * | 2000-12-28 | 2003-04-01 | Scimed Life Systems, Inc. | Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance |
US6551342B1 (en) * | 2001-08-24 | 2003-04-22 | Endovascular Technologies, Inc. | Embolic filter |
US20030093087A1 (en) * | 2001-11-15 | 2003-05-15 | Jones Donald K. | Embolic coil retrieval system |
US6575997B1 (en) * | 1999-12-23 | 2003-06-10 | Endovascular Technologies, Inc. | Embolic basket |
US20030144687A1 (en) * | 1999-05-07 | 2003-07-31 | Salviac Limited | Support frame for an embolic protection device |
US6679893B1 (en) * | 2000-11-16 | 2004-01-20 | Chestnut Medical Technologies, Inc. | Grasping device and method of use |
US6685738B2 (en) * | 2000-01-31 | 2004-02-03 | Scimed Life Systems, Inc. | Braided endoluminal device having tapered filaments |
US6702782B2 (en) * | 2001-06-26 | 2004-03-09 | Concentric Medical, Inc. | Large lumen balloon catheter |
US20040066288A1 (en) * | 2002-09-24 | 2004-04-08 | Ryozo Okumura | Tire air pressure monitoring system |
US20040073243A1 (en) * | 2000-06-29 | 2004-04-15 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20040079429A1 (en) * | 2001-06-26 | 2004-04-29 | Concentric Medical, Inc. | Balloon catherer |
US6730104B1 (en) * | 2000-06-29 | 2004-05-04 | Concentric Medical, Inc. | Methods and devices for removing an obstruction from a blood vessel |
US6745080B2 (en) * | 1999-11-22 | 2004-06-01 | Scimed Life Systems, Inc. | Helical and pre-oriented loop structures for supporting diagnostic and therapeutic elements in contact with body tissue |
US6746468B1 (en) * | 1999-06-02 | 2004-06-08 | Concentric Medical, Inc. | Devices and methods for treating vascular malformations |
US6749619B2 (en) * | 2001-11-20 | 2004-06-15 | The Cleveland Clinic Foundation | Apparatus and method for eliminating dislodged thrombus |
US6755813B2 (en) * | 2001-11-20 | 2004-06-29 | Cleveland Clinic Foundation | Apparatus and method for performing thrombolysis |
US20040133232A1 (en) * | 1998-05-01 | 2004-07-08 | Microvention, Inc. | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders |
US20040138692A1 (en) * | 2003-01-13 | 2004-07-15 | Scimed Life Systems, Inc. | Embolus extractor |
US20050004594A1 (en) * | 2003-07-02 | 2005-01-06 | Jeffrey Nool | Devices and methods for aspirating from filters |
US20050033348A1 (en) * | 2000-06-29 | 2005-02-10 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US20050038447A1 (en) * | 2003-08-12 | 2005-02-17 | Scimed Life Systems, Inc. | Laser-cut clot puller |
US20050043756A1 (en) * | 2003-07-31 | 2005-02-24 | Vance Products Incorporated D/B/A Cook Urological Incorporated | Ureteral backstop filter and retrieval device |
US20050049619A1 (en) * | 2000-06-29 | 2005-03-03 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US20050055047A1 (en) * | 2003-09-04 | 2005-03-10 | Secant Medical, Llc | Endovascular snare for capture and removal of arterial emboli |
US6872256B2 (en) * | 1999-12-17 | 2005-03-29 | Tokyo Electron Limited | Film forming unit |
US20050085847A1 (en) * | 2003-07-22 | 2005-04-21 | Galdonik Jason A. | Fiber based embolism protection device |
US20050090857A1 (en) * | 1999-03-08 | 2005-04-28 | Ev3 Inc. | Minimally invasive medical device deployment and retrieval system |
US20050090858A1 (en) * | 2001-01-25 | 2005-04-28 | Ev3 Inc. | Distal protection device with electrospun polymer fiber matrix |
US6893431B2 (en) * | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
US20050125024A1 (en) * | 2000-06-29 | 2005-06-09 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US6905503B2 (en) * | 2001-02-09 | 2005-06-14 | Concentric Medical, Inc. | Methods and devices for delivering occlusion elements |
US20050131450A1 (en) * | 2003-12-15 | 2005-06-16 | Medtronic Vascular, Inc. | Embolic containment system with asymmetric frictional control |
US20060004404A1 (en) * | 2001-06-28 | 2006-01-05 | Lithotech Medical Ltd. | Method for manufacturing a surgical device for extracting a foreign object |
US20060009784A1 (en) * | 2004-07-07 | 2006-01-12 | Percutaneous Systems, Inc. | Methods and apparatus for deploying conformed structures in body lumens |
US20060047286A1 (en) * | 2004-08-31 | 2006-03-02 | Stephen West | Clot retrieval device |
US7037320B2 (en) * | 2001-12-21 | 2006-05-02 | Salviac Limited | Support frame for an embolic protection device |
US20060095070A1 (en) * | 1997-11-07 | 2006-05-04 | Paul Gilson | Embolic portection device |
US7058456B2 (en) * | 2002-08-09 | 2006-06-06 | Concentric Medical, Inc. | Methods and devices for changing the shape of a medical device |
US20060129166A1 (en) * | 2004-12-15 | 2006-06-15 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Radiopaque manipulation devices |
US20060129180A1 (en) * | 1997-05-08 | 2006-06-15 | Tsugita Ross S | Methods of protecting a patient from embolization during surgery |
US7169165B2 (en) * | 2001-01-16 | 2007-01-30 | Boston Scientific Scimed, Inc. | Rapid exchange sheath for deployment of medical devices and methods of use |
US7179273B1 (en) * | 1999-06-21 | 2007-02-20 | Endovascular Technologies, Inc. | Filter/emboli extractor for use in variable sized blood vessels |
US7182771B1 (en) * | 2001-12-20 | 2007-02-27 | Russell A. Houser | Vascular couplers, techniques, methods, and accessories |
US7235061B2 (en) * | 1999-08-03 | 2007-06-26 | Boston Scientific Scimed, Inc. | Guided filter with support wire and methods of use |
US20090069828A1 (en) * | 2007-04-17 | 2009-03-12 | Lazarus Effect, Inc. | Articulating retrieval devices |
Family Cites Families (264)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2918919A (en) | 1957-04-19 | 1959-12-29 | American Cystoscope Makers Inc | Combined ureteral stone remover and drain |
US3996938A (en) | 1975-07-10 | 1976-12-14 | Clark Iii William T | Expanding mesh catheter |
IT1126526B (en) | 1979-12-07 | 1986-05-21 | Enrico Dormia | SURGICAL EXTRACTOR TO REMOVE FOREIGN BODIES THAT ARE FOUND IN THE NATURAL ROUTES OF THE HUMAN BODY, AS CALCULATIONS AND SIMILAR |
US4611594A (en) | 1984-04-11 | 1986-09-16 | Northwestern University | Medical instrument for containment and removal of calculi |
DE3415204A1 (en) | 1984-04-21 | 1985-10-31 | Poccino-Espresso Import- und Export GmbH, 4000 Düsseldorf | ESPRESSO COFFEE MAKER |
DE3501707A1 (en) | 1985-01-19 | 1986-07-24 | Georg 3008 Garbsen Pauldrach | Device for crushing concrements formed in hollow organs |
EP0200668A3 (en) | 1985-04-25 | 1988-03-09 | FOGARTY, Thomas J. | Apparatus and method for dislodging and removing occlusive objects from body passages |
US4699147A (en) * | 1985-09-25 | 1987-10-13 | Cordis Corporation | Intraventricular multielectrode cardial mapping probe and method for using same |
US4650466A (en) | 1985-11-01 | 1987-03-17 | Angiobrade Partners | Angioplasty device |
US4790812A (en) | 1985-11-15 | 1988-12-13 | Hawkins Jr Irvin F | Apparatus and method for removing a target object from a body passsageway |
JPH0538454Y2 (en) * | 1986-12-12 | 1993-09-29 | ||
US4873978A (en) | 1987-12-04 | 1989-10-17 | Robert Ginsburg | Device and method for emboli retrieval |
FR2624747A1 (en) | 1987-12-18 | 1989-06-23 | Delsanti Gerard | REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS |
JPH0255064A (en) * | 1988-08-03 | 1990-02-23 | Toa O | Skin removal for throm bus in blood vessel using catheter and throm bus removing system in blood vessel using catheter |
US5152777A (en) | 1989-01-25 | 1992-10-06 | Uresil Corporation | Device and method for providing protection from emboli and preventing occulsion of blood vessels |
US4969891A (en) | 1989-03-06 | 1990-11-13 | Gewertz Bruce L | Removable vascular filter |
US5147400A (en) * | 1989-05-10 | 1992-09-15 | United States Surgical Corporation | Connective tissue prosthesis |
US5034001A (en) | 1989-09-08 | 1991-07-23 | Advanced Cardiovascular Systems, Inc. | Method of repairing a damaged blood vessel with an expandable cage catheter |
CA2048307C (en) | 1990-08-14 | 1998-08-18 | Rolf Gunther | Method and apparatus for filtering blood in a blood vessel of a patient |
US5057114A (en) | 1990-09-18 | 1991-10-15 | Cook Incorporated | Medical retrieval basket |
US5449372A (en) | 1990-10-09 | 1995-09-12 | Scimed Lifesystems, Inc. | Temporary stent and methods for use and manufacture |
DE69328096T2 (en) * | 1992-06-26 | 2000-09-14 | Schneider Usa Inc | CATHETER WITH EXTENDABLE MACHINE WIRE TIP |
US5443478A (en) * | 1992-09-02 | 1995-08-22 | Board Of Regents, The University Of Texas System | Multi-element intravascular occlusion device |
US5336178A (en) | 1992-11-02 | 1994-08-09 | Localmed, Inc. | Intravascular catheter with infusion array |
US5490859A (en) | 1992-11-13 | 1996-02-13 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
US5458375A (en) * | 1994-04-25 | 1995-10-17 | The Anspach Effort, Inc. | Rotary connector for fluid conduits |
EP1695673A3 (en) * | 1994-07-08 | 2009-07-08 | ev3 Inc. | Intravascular filtering device |
WO2000053120A1 (en) | 1994-07-08 | 2000-09-14 | Microvena Corporation | Minimally invasive medical device deployment and retrieval system |
US5658296A (en) | 1994-11-21 | 1997-08-19 | Boston Scientific Corporation | Method for making surgical retrieval baskets |
US5549626A (en) | 1994-12-23 | 1996-08-27 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Vena caval filter |
FR2735967B1 (en) | 1995-06-27 | 1998-03-06 | Perouse Implant Lab | VASCULAR SURGERY TOOL AND ITS USE |
EP0879068A4 (en) | 1996-02-02 | 1999-04-21 | Transvascular Inc | Methods and apparatus for blocking flow through blood vessels |
US5846251A (en) | 1996-07-22 | 1998-12-08 | Hart; Charles C. | Access device with expandable containment member |
US5971938A (en) | 1996-04-02 | 1999-10-26 | Hart; Charles C. | Access device with expandable containment member |
US6096053A (en) | 1996-05-03 | 2000-08-01 | Scimed Life Systems, Inc. | Medical retrieval basket |
US6800080B1 (en) | 1996-05-03 | 2004-10-05 | Scimed Life Systems, Inc. | Medical retrieval device |
US5662671A (en) | 1996-07-17 | 1997-09-02 | Embol-X, Inc. | Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries |
US5972019A (en) * | 1996-07-25 | 1999-10-26 | Target Therapeutics, Inc. | Mechanical clot treatment device |
US6080170A (en) | 1996-07-26 | 2000-06-27 | Kensey Nash Corporation | System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels |
US6391044B1 (en) | 1997-02-03 | 2002-05-21 | Angioguard, Inc. | Vascular filter system |
US5882329A (en) | 1997-02-12 | 1999-03-16 | Prolifix Medical, Inc. | Apparatus and method for removing stenotic material from stents |
US5827324A (en) | 1997-03-06 | 1998-10-27 | Scimed Life Systems, Inc. | Distal protection device |
US6733515B1 (en) * | 1997-03-12 | 2004-05-11 | Neomend, Inc. | Universal introducer |
US5980554A (en) | 1997-05-05 | 1999-11-09 | Micro Therapeutics, Inc. | Wire frame partial flow obstruction for aneurysm treatment |
US5836966A (en) | 1997-05-22 | 1998-11-17 | Scimed Life Systems, Inc. | Variable expansion force stent |
US5947995A (en) | 1997-06-06 | 1999-09-07 | Samuels; Shaun Lawrence Wilkie | Method and apparatus for removing blood clots and other objects |
JP3527619B2 (en) | 1997-06-25 | 2004-05-17 | ペンタックス株式会社 | Endoscope stent |
US6245088B1 (en) | 1997-07-07 | 2001-06-12 | Samuel R. Lowery | Retrievable umbrella sieve and method of use |
US5984957A (en) | 1997-08-12 | 1999-11-16 | Schneider (Usa) Inc | Radially expanded prostheses with axial diameter control |
US5968090A (en) * | 1997-09-08 | 1999-10-19 | United States Surgical Corp. | Endovascular graft and method |
JP4149132B2 (en) | 1997-10-01 | 2008-09-10 | ボストン・サイエンティフィック・リミテッド | Basket with one or more movable legs |
DE69832998T2 (en) | 1997-10-01 | 2006-08-31 | Boston Scientific Ltd., St. Michael | CATCHES WITH ONE OR MORE MOBILE GRAPHIC ARMS |
US6099534A (en) | 1997-10-01 | 2000-08-08 | Scimed Life Systems, Inc. | Releasable basket |
US6443972B1 (en) * | 1997-11-19 | 2002-09-03 | Cordis Europa N.V. | Vascular filter |
US6168570B1 (en) | 1997-12-05 | 2001-01-02 | Micrus Corporation | Micro-strand cable with enhanced radiopacity |
US6602265B2 (en) | 1998-02-10 | 2003-08-05 | Artemis Medical, Inc. | Tissue separation medical device and method |
WO1999039649A1 (en) | 1998-02-10 | 1999-08-12 | Dubrul William R | Occlusion, anchoring, tensioning and flow direction apparatus and methods for use |
CA2330471A1 (en) | 1998-05-21 | 1999-11-25 | The Trustees Of The University Of Pennsylvania | Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots |
US6217609B1 (en) * | 1998-06-30 | 2001-04-17 | Schneider (Usa) Inc | Implantable endoprosthesis with patterned terminated ends and methods for making same |
US6656218B1 (en) | 1998-07-24 | 2003-12-02 | Micrus Corporation | Intravascular flow modifier and reinforcement device |
US7314477B1 (en) | 1998-09-25 | 2008-01-01 | C.R. Bard Inc. | Removable embolus blood clot filter and filter delivery unit |
US20020138094A1 (en) | 1999-02-12 | 2002-09-26 | Thomas Borillo | Vascular filter system |
US6159220A (en) * | 1999-03-11 | 2000-12-12 | Scimed Life Systems, Inc. | Medical retrieval device |
US20020169473A1 (en) | 1999-06-02 | 2002-11-14 | Concentric Medical, Inc. | Devices and methods for treating vascular malformations |
US6616679B1 (en) * | 1999-07-30 | 2003-09-09 | Incept, Llc | Rapid exchange vascular device for emboli and thrombus removal and methods of use |
US6168579B1 (en) | 1999-08-04 | 2001-01-02 | Scimed Life Systems, Inc. | Filter flush system and methods of use |
US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
US6454775B1 (en) * | 1999-12-06 | 2002-09-24 | Bacchus Vascular Inc. | Systems and methods for clot disruption and retrieval |
US6261820B1 (en) | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
US6364895B1 (en) * | 1999-10-07 | 2002-04-02 | Prodesco, Inc. | Intraluminal filter |
US6673042B1 (en) * | 1999-11-22 | 2004-01-06 | Wilfred J. Samson | Expandable venous cannula and method of use |
US6645199B1 (en) | 1999-11-22 | 2003-11-11 | Scimed Life Systems, Inc. | Loop structures for supporting diagnostic and therapeutic elements contact with body tissue and expandable push devices for use with same |
US7033776B2 (en) | 1999-12-17 | 2006-04-25 | Amgen Inc. | Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases |
US6660021B1 (en) * | 1999-12-23 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Intravascular device and system |
US6702834B1 (en) | 1999-12-30 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices |
DE10000137A1 (en) * | 2000-01-04 | 2001-07-12 | Pfm Prod Fuer Die Med Ag | Implantate for closing defect apertures in human or animal bodies, bearing structure of which can be reversed from secondary to primary form by elastic force |
US6540768B1 (en) | 2000-02-09 | 2003-04-01 | Cordis Corporation | Vascular filter system |
US6344044B1 (en) * | 2000-02-11 | 2002-02-05 | Edwards Lifesciences Corp. | Apparatus and methods for delivery of intraluminal prosthesis |
DE60102075T2 (en) | 2000-03-10 | 2004-09-16 | Radius Medical Technologies, Inc., Maynard | SURGICAL Sling |
ATE353604T1 (en) | 2000-03-10 | 2007-03-15 | Michael Anthony T Don | FILTER EXPANSION DEVICE FOR PREVENTING VASCULAR EMBOLY |
US20010031981A1 (en) * | 2000-03-31 | 2001-10-18 | Evans Michael A. | Method and device for locating guidewire and treating chronic total occlusions |
US6592616B1 (en) * | 2000-04-28 | 2003-07-15 | Advanced Cardiovascular Systems, Inc. | System and device for minimizing embolic risk during an interventional procedure |
US6602271B2 (en) * | 2000-05-24 | 2003-08-05 | Medtronic Ave, Inc. | Collapsible blood filter with optimal braid geometry |
US6939362B2 (en) | 2001-11-27 | 2005-09-06 | Advanced Cardiovascular Systems, Inc. | Offset proximal cage for embolic filtering devices |
US7727243B2 (en) * | 2000-06-29 | 2010-06-01 | Concentric Medical., Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US20050288686A1 (en) | 2000-06-29 | 2005-12-29 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US7727242B2 (en) | 2000-06-29 | 2010-06-01 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US6663650B2 (en) | 2000-06-29 | 2003-12-16 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US8298257B2 (en) * | 2000-06-29 | 2012-10-30 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US20070208371A1 (en) | 2000-06-29 | 2007-09-06 | Concentric Medical, Inc. | Devices and methods for removing obstructions from a patient and methods for making obstruction removing devices |
CA2411699A1 (en) | 2000-06-29 | 2002-01-10 | Ivan Sepetka | Systems, methods and devices for removing obstructions from a blood vessel |
FR2813518B1 (en) * | 2000-09-04 | 2002-10-31 | Claude Mialhe | VASCULAR OCCLUSION DEVICE, APPARATUS AND METHOD OF USE |
US6500185B1 (en) | 2000-09-29 | 2002-12-31 | Primus Medical, Inc. | Snare device |
CN101301218A (en) | 2001-01-09 | 2008-11-12 | 微温森公司 | Catheter for excising embolus and treatment method thereof |
EP1355693B1 (en) | 2001-01-10 | 2008-01-09 | Cordis Neurovascular, Inc. | Embolic coil introducer system |
US6936059B2 (en) | 2001-01-16 | 2005-08-30 | Scimed Life Systems, Inc. | Endovascular guidewire filter and methods of use |
US6610077B1 (en) * | 2001-01-23 | 2003-08-26 | Endovascular Technologies, Inc. | Expandable emboli filter and thrombectomy device |
US6585753B2 (en) * | 2001-03-28 | 2003-07-01 | Scimed Life Systems, Inc. | Expandable coil stent |
US6636758B2 (en) * | 2001-05-01 | 2003-10-21 | Concentric Medical, Inc. | Marker wire and process for using it |
EP1392175A2 (en) | 2001-05-04 | 2004-03-03 | Concentric Medical | Hydrogel filament vaso-occlusive device |
WO2002089863A1 (en) | 2001-05-04 | 2002-11-14 | Concentric Medical | Bioactive polymer vaso-occlusive device |
AU2002340749A1 (en) | 2001-05-04 | 2002-11-18 | Concentric Medical | Coated combination vaso-occlusive device |
EP1392182A1 (en) | 2001-05-04 | 2004-03-03 | Concentric Medical | Hydrogel vaso-occlusive device |
US20020188314A1 (en) | 2001-06-07 | 2002-12-12 | Microvena Corporation | Radiopaque distal embolic protection device |
US6793665B2 (en) | 2001-06-18 | 2004-09-21 | Rex Medical, L.P. | Multiple access vein filter |
IL144213A0 (en) | 2001-07-09 | 2002-05-23 | Mind Guard Ltd | Implantable filter |
US6638294B1 (en) | 2001-08-30 | 2003-10-28 | Advanced Cardiovascular Systems, Inc. | Self furling umbrella frame for carotid filter |
US7332330B2 (en) | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
US7052500B2 (en) * | 2001-10-19 | 2006-05-30 | Scimed Life Systems, Inc. | Embolus extractor |
WO2003037191A1 (en) | 2001-10-26 | 2003-05-08 | Concentric Medical | Device for vaso-occlusion |
US7286866B2 (en) | 2001-11-05 | 2007-10-23 | Ge Medical Systems Global Technology Company, Llc | Method, system and computer product for cardiac interventional procedure planning |
US7488313B2 (en) * | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
US20030176884A1 (en) | 2002-03-12 | 2003-09-18 | Marwane Berrada | Everted filter device |
US6953465B2 (en) * | 2002-03-25 | 2005-10-11 | Concentric Medical, Inc. | Containers and methods for delivering vaso-occluding filaments and particles |
DE10217757A1 (en) | 2002-04-20 | 2003-10-30 | Friedhelm Brassel | Medical retriever |
US20040172056A1 (en) * | 2002-07-12 | 2004-09-02 | Guterman Lee R. | Bifurcated aneurysm buttress arrangement |
DE10242444A1 (en) * | 2002-09-11 | 2004-04-01 | pfm Produkte für die Medizin AG | extractor |
US20040115164A1 (en) | 2002-12-17 | 2004-06-17 | Pierce Ryan K. | Soft filament occlusive device delivery system |
US7404821B2 (en) | 2003-01-30 | 2008-07-29 | Vascular Control Systems, Inc. | Treatment for post partum hemorrhage |
US7220271B2 (en) | 2003-01-30 | 2007-05-22 | Ev3 Inc. | Embolic filters having multiple layers and controlled pore size |
US20040153025A1 (en) * | 2003-02-03 | 2004-08-05 | Seifert Paul S. | Systems and methods of de-endothelialization |
US20040199201A1 (en) * | 2003-04-02 | 2004-10-07 | Scimed Life Systems, Inc. | Embolectomy devices |
US7122003B2 (en) * | 2003-04-16 | 2006-10-17 | Granit Medical Innovations, Llc | Endoscopic retractor instrument and associated method |
CL2004000985A1 (en) * | 2003-05-16 | 2005-01-14 | Wyeth Corp | COMPOUNDS DERIVED FROM PHENYLQUINOLINS; PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS; AND USE TO TREAT OSTEOPOROSIS, PAGET DISEASE, VASCULAR DANO, OSTEOARTRITIS, OSEO CANCER, OVARIC CANCER, PROSTATIC CANCER, HYPERCHOLESTEROLEMIA, ATEROSC |
KR100561713B1 (en) | 2003-05-23 | 2006-03-20 | (주) 태웅메디칼 | Flexible self-expandable stent and methods for making the stent |
US7051126B1 (en) | 2003-08-19 | 2006-05-23 | F5 Networks, Inc. | Hardware accelerated compression |
US7371248B2 (en) * | 2003-10-14 | 2008-05-13 | Medtronic Vascular, Inc. | Steerable distal protection guidewire and methods of use |
US20050085826A1 (en) | 2003-10-21 | 2005-04-21 | Scimed Life Systems, Inc. | Unfolding balloon catheter for proximal embolus protection |
US7344550B2 (en) | 2003-10-21 | 2008-03-18 | Boston Scientific Scimed, Inc. | Clot removal device |
WO2005052366A2 (en) | 2003-11-20 | 2005-06-09 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Portable hand pump for evacuation of fluids |
JP2005160648A (en) * | 2003-12-01 | 2005-06-23 | Terumo Corp | Wire and medical instrument for removing foreign body in blood vessel |
US7763011B2 (en) | 2003-12-22 | 2010-07-27 | Boston Scientific Scimed, Inc. | Variable density braid stent |
US7303758B2 (en) | 2004-01-20 | 2007-12-04 | Cordis Corporation | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury |
US7341569B2 (en) | 2004-01-30 | 2008-03-11 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
WO2005081949A2 (en) * | 2004-02-24 | 2005-09-09 | Board Of Regents, The University Of Texas System | Foreign body retrieval devices |
US20070118165A1 (en) | 2004-03-08 | 2007-05-24 | Demello Jonathan R | System and method for removal of material from a blood vessel using a small diameter catheter |
US8777974B2 (en) | 2004-03-19 | 2014-07-15 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects |
WO2005094283A2 (en) | 2004-03-25 | 2005-10-13 | Hauser David L | Vascular filter device |
US20050228417A1 (en) | 2004-03-26 | 2005-10-13 | Teitelbaum George P | Devices and methods for removing a matter from a body cavity of a patient |
US7294311B2 (en) | 2004-04-05 | 2007-11-13 | Bio/Data Corporation | Clot retainer |
US20050234501A1 (en) * | 2004-04-15 | 2005-10-20 | Barone David D | Braided intraluminal filter |
US20050277978A1 (en) | 2004-06-09 | 2005-12-15 | Secant Medical, Llc | Three-dimensional coils for treatment of vascular aneurysms |
IE20040399A1 (en) | 2004-06-14 | 2005-12-14 | Seamus Duffy | Parallel jaw locking snap ring pliers |
US20050283166A1 (en) | 2004-06-17 | 2005-12-22 | Secant Medical, Llc | Expandible snare |
US20050283182A1 (en) | 2004-06-21 | 2005-12-22 | Concentric Medical, Inc. | Systems and methods for intraluminal delivery of occlusive elements |
US7240516B2 (en) | 2004-08-03 | 2007-07-10 | Medtronic Vascular, Inc. | Flexible resheathable stent design |
US20060036280A1 (en) | 2004-08-11 | 2006-02-16 | Concentric Medical, Inc. | Systems and methods for severing occlusive elements from a delivery catheter |
DE102004040868A1 (en) | 2004-08-23 | 2006-03-09 | Miloslavski, Elina | Device for removing thrombi |
US9655633B2 (en) | 2004-09-10 | 2017-05-23 | Penumbra, Inc. | System and method for treating ischemic stroke |
WO2006026998A1 (en) | 2004-09-10 | 2006-03-16 | Pharmaorigin Aps | Methods for treating local tracheal, bronchial or alveolar bleeding or hemoptysis |
US8366735B2 (en) | 2004-09-10 | 2013-02-05 | Penumbra, Inc. | System and method for treating ischemic stroke |
US20060058837A1 (en) * | 2004-09-10 | 2006-03-16 | Arani Bose | System and method for treating ischemic stroke |
US7279000B2 (en) | 2004-09-29 | 2007-10-09 | Angiodynamics Inc | Permanent blood clot filter with capability of being retrieved |
WO2006084019A2 (en) | 2005-02-01 | 2006-08-10 | Primus Medical Group, Llc. | Snare with capture-area enhancement |
US20060190070A1 (en) * | 2005-02-23 | 2006-08-24 | Dieck Martin S | Rail stent and methods of use |
US20060229638A1 (en) | 2005-03-29 | 2006-10-12 | Abrams Robert M | Articulating retrieval device |
US20060276805A1 (en) | 2005-05-03 | 2006-12-07 | Yu Chun H | Vessel recanalizer |
US7645290B2 (en) | 2005-05-05 | 2010-01-12 | Lucas Paul R | Multi-functional thrombectomy device |
US7967747B2 (en) | 2005-05-10 | 2011-06-28 | Boston Scientific Scimed, Inc. | Filtering apparatus and methods of use |
WO2006135823A2 (en) | 2005-06-09 | 2006-12-21 | Baylor College Of Medicine | Segmented embolectomy catheter |
US20060287668A1 (en) | 2005-06-16 | 2006-12-21 | Fawzi Natalie V | Apparatus and methods for intravascular embolic protection |
WO2007026299A2 (en) | 2005-08-30 | 2007-03-08 | Koninklijke Philips Electronics, N.V. | Method of using a combination imaging and therapy transducer to dissolve blood clots |
US8252017B2 (en) * | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
DE102005059670A1 (en) | 2005-12-12 | 2007-06-14 | Phenox Gmbh | Device for removing thrombi from blood vessels |
US7837702B2 (en) | 2005-12-21 | 2010-11-23 | Nexeon Medsystems, Inc. | Interventional catheter for retrograde use having embolic protection capability and methods of use |
US20070149996A1 (en) | 2005-12-28 | 2007-06-28 | Medtronic Vascular, Inc. | Low profile filter |
BRPI0707681A2 (en) | 2006-02-01 | 2011-05-10 | Cleveland Clinic Foudation | Method and apparatus for increasing blood flow through a blocked artery |
WO2007092820A2 (en) * | 2006-02-03 | 2007-08-16 | Lazarus Effect, Inc. | Methods and devices for restoring blood flow within blocked vasculature |
US7993302B2 (en) | 2006-05-09 | 2011-08-09 | Stephen Hebert | Clot retrieval device |
US20070270905A1 (en) | 2006-05-18 | 2007-11-22 | Cook Incorporated | Patent foramen ovale closure device and method |
CA2655158A1 (en) | 2006-06-05 | 2007-12-13 | C.R. Bard Inc. | Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access |
EP1891998B1 (en) | 2006-08-24 | 2019-03-13 | Alka Kumar | Surgical aspiration system |
DE102006044831A1 (en) | 2006-09-20 | 2008-04-03 | Phenox Gmbh | Device for removing thrombi from blood vessels |
US20080097401A1 (en) | 2006-09-22 | 2008-04-24 | Trapp Benjamin M | Cerebral vasculature device |
US8623842B2 (en) | 2006-09-27 | 2014-01-07 | Hemostasis, Llc | Hemostatic agent and method |
WO2008127287A2 (en) | 2006-10-11 | 2008-10-23 | Biolife, L.L.C. | Materials and methods for wound treatment |
CN101578070A (en) | 2006-10-26 | 2009-11-11 | 切斯纳特医学技术公司 | Intracorporeal grasping device |
WO2008072243A2 (en) | 2006-12-15 | 2008-06-19 | Dan Nahoom | Methods and devices to remove blood clot and plaque deposit |
US7914549B2 (en) | 2007-01-05 | 2011-03-29 | Hesham Morsi | Mechanical embolectomy and suction catheter |
US9387062B2 (en) | 2007-01-31 | 2016-07-12 | Stanley Batiste | Intravenous deep vein thrombosis filter and method of filter placement |
WO2008097998A1 (en) | 2007-02-05 | 2008-08-14 | Javid Ahmad E | Ultrasound method and apparatus for tumor ablation, clot lysis, and imaging |
US20080312645A1 (en) | 2007-02-05 | 2008-12-18 | Boston Scientific Scimed, Inc. | Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation |
US20080206134A1 (en) | 2007-02-22 | 2008-08-28 | Denny Lo | Radio-opaque hemostatic agents and devices and methods for the delivery thereof |
WO2008113122A1 (en) | 2007-03-20 | 2008-09-25 | Ventrassist Pty Ltd | Heart assist device, cannula and filter therefor |
US8535334B2 (en) | 2007-04-17 | 2013-09-17 | Lazarus Effect, Inc. | Complex wire formed devices |
US20080269789A1 (en) | 2007-04-27 | 2008-10-30 | Uri Eli | Implantable device with miniature rotating portion for the treatment of atherosclerosis, especially vulnerable plaques |
US9198687B2 (en) | 2007-10-17 | 2015-12-01 | Covidien Lp | Acute stroke revascularization/recanalization systems processes and products thereby |
US9220522B2 (en) | 2007-10-17 | 2015-12-29 | Covidien Lp | Embolus removal systems with baskets |
US20100174309A1 (en) | 2008-05-19 | 2010-07-08 | Mindframe, Inc. | Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter |
US10123803B2 (en) | 2007-10-17 | 2018-11-13 | Covidien Lp | Methods of managing neurovascular obstructions |
US20100256600A1 (en) | 2009-04-04 | 2010-10-07 | Ferrera David A | Neurovascular otw pta balloon catheter and delivery system |
US8088140B2 (en) | 2008-05-19 | 2012-01-03 | Mindframe, Inc. | Blood flow restorative and embolus removal methods |
US8926680B2 (en) | 2007-11-12 | 2015-01-06 | Covidien Lp | Aneurysm neck bridging processes with revascularization systems methods and products thereby |
US8066757B2 (en) | 2007-10-17 | 2011-11-29 | Mindframe, Inc. | Blood flow restoration and thrombus management methods |
JP2009134439A (en) * | 2007-11-29 | 2009-06-18 | Nec Electronics Corp | Layout design method using soft macro, data structure for soft macro and creation method for soft macro library |
WO2009086482A1 (en) | 2007-12-26 | 2009-07-09 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US20090192518A1 (en) | 2008-01-24 | 2009-07-30 | Boston Scientific Scimed, Inc. | Apparatus and method for loading and delivering a stent having improved handles to control relative catheter component movement |
WO2009126935A2 (en) | 2008-04-11 | 2009-10-15 | Mindframe, Inc. | Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby |
WO2009132045A2 (en) | 2008-04-21 | 2009-10-29 | Nfocus Neuromedical, Inc. | Braid-ball embolic devices and delivery systems |
EP2346431A4 (en) | 2008-11-03 | 2012-10-03 | Univ Ben Gurion | Method and apparatus for thrombus dissolution/thrombectomy by an electrode catheter device |
WO2010102307A1 (en) | 2009-03-06 | 2010-09-10 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
WO2011053984A1 (en) | 2009-11-02 | 2011-05-05 | Pulse Therapeutics, Inc. | Magnetomotive stator system and methods for wireless control of magnetic rotors |
US8906057B2 (en) | 2010-01-04 | 2014-12-09 | Aneuclose Llc | Aneurysm embolization by rotational accumulation of mass |
WO2011091383A1 (en) | 2010-01-22 | 2011-07-28 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
WO2012009675A2 (en) | 2010-07-15 | 2012-01-19 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US8603014B2 (en) | 2010-10-05 | 2013-12-10 | Cerevast Therapeutics, Inc. | Hands-free operator-independent transcranial ultrasound apparatus and methods |
DE102010051740A1 (en) | 2010-11-19 | 2012-05-24 | Phenox Gmbh | thrombectomy |
DE102011101522A1 (en) | 2011-05-13 | 2012-11-15 | Phenox Gmbh | thrombectomy |
US11026708B2 (en) | 2011-07-26 | 2021-06-08 | Thrombx Medical, Inc. | Intravascular thromboembolectomy device and method using the same |
US10779855B2 (en) | 2011-08-05 | 2020-09-22 | Route 92 Medical, Inc. | Methods and systems for treatment of acute ischemic stroke |
US11311332B2 (en) | 2011-08-23 | 2022-04-26 | Magneto Thrombectomy Solutions Ltd. | Thrombectomy devices |
US8837800B1 (en) | 2011-10-28 | 2014-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | Automated detection of arterial input function and/or venous output function voxels in medical imaging |
GB2498349B (en) | 2012-01-10 | 2013-12-11 | Cook Medical Technologies Llc | Object capture device |
JP5907821B2 (en) | 2012-06-26 | 2016-04-26 | 浜松ホトニクス株式会社 | Thrombectomy device |
US9211132B2 (en) | 2012-06-27 | 2015-12-15 | MicoVention, Inc. | Obstruction removal system |
US9445828B2 (en) | 2012-07-05 | 2016-09-20 | Cognition Medical Corp. | Methods, devices, and systems for postconditioning with clot removal |
WO2014028528A1 (en) | 2012-08-13 | 2014-02-20 | Microvention, Inc. | Shaped removal device |
US9204887B2 (en) | 2012-08-14 | 2015-12-08 | W. L. Gore & Associates, Inc. | Devices and systems for thrombus treatment |
US9539022B2 (en) | 2012-11-28 | 2017-01-10 | Microvention, Inc. | Matter conveyance system |
US9585741B2 (en) | 2013-02-22 | 2017-03-07 | NeuroVasc Technologies, Inc | Embolus removal device with blood flow restriction and related methods |
US20140276074A1 (en) | 2013-03-13 | 2014-09-18 | W.L. Gore & Associates, Inc. | Flexible Driveshafts with Bi-Directionally Balanced Torsional Stiffness Properties |
US9642635B2 (en) | 2013-03-13 | 2017-05-09 | Neuravi Limited | Clot removal device |
CN109157304B (en) | 2013-03-14 | 2021-12-31 | 尼尔拉维有限公司 | A clot retrieval device for removing a clogged clot from a blood vessel |
SI2967611T1 (en) | 2013-03-14 | 2019-04-30 | Neuravi Limited | Devices for removal of acute blockages from blood vessels |
US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
EP3013421B8 (en) | 2013-06-28 | 2020-04-08 | Koninklijke Philips N.V. | Transducer placement and registration for image-guided sonothrombolysis |
US9265512B2 (en) | 2013-12-23 | 2016-02-23 | Silk Road Medical, Inc. | Transcarotid neurovascular catheter |
JP6495241B2 (en) | 2014-03-11 | 2019-04-03 | テルモ株式会社 | Method for manufacturing medical device and medical device |
WO2015141317A1 (en) | 2014-03-20 | 2015-09-24 | テルモ株式会社 | Foreign matter removal device |
US9241699B1 (en) | 2014-09-04 | 2016-01-26 | Silk Road Medical, Inc. | Methods and devices for transcarotid access |
US10792056B2 (en) | 2014-06-13 | 2020-10-06 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10441301B2 (en) | 2014-06-13 | 2019-10-15 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
WO2016010996A1 (en) | 2014-07-15 | 2016-01-21 | Stryker Corporation | Vascular access system and method of use |
US9801643B2 (en) | 2014-09-02 | 2017-10-31 | Cook Medical Technologies Llc | Clot retrieval catheter |
KR101530828B1 (en) | 2014-09-23 | 2015-06-24 | 윤성원 | endovascular device for thrombus removal and flow restoration |
WO2016089664A1 (en) | 2014-12-03 | 2016-06-09 | Stryker European Holdings I, Llc | Apparatus and methods for removing an obstruction form a bodily duct of a patient |
US10518066B2 (en) | 2015-01-09 | 2019-12-31 | Mivi Neuroscience, Inc. | Medical guidewires for tortuous vessels |
WO2016157072A1 (en) | 2015-03-30 | 2016-10-06 | Koninklijke Philips N.V. | Ultrasonic transducer array for sonothrombolysis treatment and monitoring |
CN112220980B (en) | 2015-04-10 | 2023-12-08 | 丝绸之路医药公司 | System for establishing retrograde carotid blood flow |
EP3282962B1 (en) | 2015-04-16 | 2019-10-16 | Stryker Corporation | Embolectomy devices |
EP3302309A4 (en) | 2015-06-06 | 2019-02-06 | The Hong Kong University of Science and Technology | Radio frequency electro-thrombectomy device |
WO2017053271A1 (en) | 2015-09-21 | 2017-03-30 | Stryker Corporation | Embolectomy devices |
CN108024821B (en) | 2015-09-21 | 2020-10-30 | 斯瑞克公司 | Embolectomy device |
WO2017062383A1 (en) | 2015-10-07 | 2017-04-13 | Stryker Corporation | Multiple barrel clot removal devices |
US10485564B2 (en) | 2015-12-14 | 2019-11-26 | Mg Stroke Analytics Inc. | Systems and methods to improve perfusion pressure during endovascular intervention |
KR20220098399A (en) | 2016-02-10 | 2022-07-12 | 마이크로벤션, 인코포레이티드 | Intravascular treatment site access |
US10252024B2 (en) | 2016-04-05 | 2019-04-09 | Stryker Corporation | Medical devices and methods of manufacturing same |
MA44884A (en) | 2016-05-06 | 2019-03-13 | Mayo Found Medical Education & Res | DEVICES AND METHODS FOR THROMBECTOMY OF THE INTERNAL CAROTID ARTERY |
WO2018019829A1 (en) | 2016-07-26 | 2018-02-01 | Neuravi Limited | A clot retrieval system for removing occlusive clot from a blood vessel |
WO2018033401A1 (en) | 2016-08-17 | 2018-02-22 | Neuravi Limited | A clot retrieval system for removing occlusive clot from a blood vessel |
CN109906058B (en) | 2016-09-06 | 2022-06-07 | 尼尔拉维有限公司 | Clot retrieval device for removing an occluded clot from a blood vessel |
US9993257B2 (en) | 2016-09-07 | 2018-06-12 | NeuroVarc Technologies Inc. | Clot retrieval device for ischemic stroke treatment |
JP6804916B2 (en) | 2016-09-27 | 2020-12-23 | 浜松ホトニクス株式会社 | Monitor device and how to operate the monitor device |
WO2018093574A1 (en) | 2016-11-16 | 2018-05-24 | Zaidat Osama O | System and device for engulfing thrombi |
US10709466B2 (en) | 2016-11-23 | 2020-07-14 | Microvention, Inc. | Obstruction removal system |
JP7169971B2 (en) | 2016-11-23 | 2022-11-11 | マイクロベンション インコーポレイテッド | Obstruction removal system |
US10932802B2 (en) | 2017-01-26 | 2021-03-02 | Mg Stroke Analytics Inc. | Thrombus retrieval stents and methods of using for treatment of ischemic stroke |
US20190209189A1 (en) | 2017-01-26 | 2019-07-11 | Mayank Goyal | Thrombus retrieval stents and methods of using for treatment of ischemic stroke |
CA3089759A1 (en) | 2017-02-09 | 2018-08-16 | Mg Stroke Analytics Inc. | Catheter systems for accessing the brain for treatment of ischemic stroke |
US11116529B2 (en) | 2017-02-24 | 2021-09-14 | Stryker Corporation | Embolectomy device having multiple semi-tubular clot engaging structures |
KR102024425B1 (en) | 2017-03-08 | 2019-11-14 | 대구가톨릭대학교산학협력단 | thrombus remove device by electromagnetic field make and control |
CN110402117B (en) | 2017-03-22 | 2022-08-05 | 磁疗血栓切除术解决方案有限公司 | Thrombectomy with electrostatic and suction forces |
KR102560026B1 (en) | 2017-04-07 | 2023-07-26 | 팔메라 메디컬, 아이엔씨. | treatment organ cooling |
JP6727245B2 (en) | 2018-04-25 | 2020-07-22 | 浜松ホトニクス株式会社 | Laser thrombolysis device |
-
2007
- 2007-02-05 WO PCT/US2007/061634 patent/WO2007092820A2/en active Application Filing
- 2007-02-05 US US11/671,450 patent/US20070225749A1/en not_active Abandoned
- 2007-02-05 EP EP07763224.8A patent/EP1986568B1/en active Active
- 2007-03-09 US US11/684,521 patent/US20070185500A1/en not_active Abandoned
- 2007-03-09 US US11/684,535 patent/US20070185501A1/en not_active Abandoned
- 2007-03-09 US US11/684,546 patent/US20070198029A1/en not_active Abandoned
- 2007-03-09 US US11/684,541 patent/US20070197103A1/en not_active Abandoned
- 2007-03-12 US US11/684,982 patent/US20070198030A1/en not_active Abandoned
-
2013
- 2013-09-26 US US14/038,461 patent/US9931128B2/en active Active
-
2018
- 2018-04-01 US US15/942,547 patent/US10806473B2/en active Active
-
2020
- 2020-09-15 US US17/021,440 patent/US11596426B2/en active Active
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US2943626A (en) * | 1957-01-31 | 1960-07-05 | Dormia Enrico | Instruments for the extraction of foreign bodies |
US4807626A (en) * | 1985-02-14 | 1989-02-28 | Mcgirr Douglas B | Stone extractor and method |
US4832055A (en) * | 1988-07-08 | 1989-05-23 | Palestrant Aubrey M | Mechanically locking blood clot filter |
US5102415A (en) * | 1989-09-06 | 1992-04-07 | Guenther Rolf W | Apparatus for removing blood clots from arteries and veins |
US5300086A (en) * | 1990-01-19 | 1994-04-05 | Pierre Gory | Device with a locating member for removably implanting a blood filter in a vein of the human body |
US5192286A (en) * | 1991-07-26 | 1993-03-09 | Regents Of The University Of California | Method and device for retrieving materials from body lumens |
US5509900A (en) * | 1992-03-02 | 1996-04-23 | Kirkman; Thomas R. | Apparatus and method for retaining a catheter in a blood vessel in a fixed position |
US5496330A (en) * | 1993-02-19 | 1996-03-05 | Boston Scientific Corporation | Surgical extractor with closely angularly spaced individual filaments |
US5733302A (en) * | 1993-03-25 | 1998-03-31 | Hemodynamics, Inc. | Cardiovascular stent and retrieval apparatus |
US5741325A (en) * | 1993-10-01 | 1998-04-21 | Emory University | Self-expanding intraluminal composite prosthesis |
US5709704A (en) * | 1994-11-30 | 1998-01-20 | Boston Scientific Corporation | Blood clot filtering |
US20050055033A1 (en) * | 1995-02-02 | 2005-03-10 | Boston Scientific Corporation. | Surgical extractor |
US6350266B1 (en) * | 1995-02-02 | 2002-02-26 | Scimed Life Systems, Inc. | Hybrid stone retrieval device |
US6872211B2 (en) * | 1995-02-02 | 2005-03-29 | Scimed Life Systems, Inc. | Hybrid stone retrieval device |
US6383196B1 (en) * | 1995-02-02 | 2002-05-07 | Scimed Life Systems, Inc. | Surgical extractor |
US6168603B1 (en) * | 1995-02-02 | 2001-01-02 | Boston Scientific Corporation | Surgical extractor |
US6506204B2 (en) * | 1996-01-24 | 2003-01-14 | Aga Medical Corporation | Method and apparatus for occluding aneurysms |
US6692509B2 (en) * | 1996-02-02 | 2004-02-17 | Regents Of The University Of California | Method of using a clot capture coil |
US6530935B2 (en) * | 1996-02-02 | 2003-03-11 | Regents Of The University Of California, The | Clot capture coil and method of using the same |
US5895398A (en) * | 1996-02-02 | 1999-04-20 | The Regents Of The University Of California | Method of using a clot capture coil |
US20030004542A1 (en) * | 1996-02-02 | 2003-01-02 | Wensel Jeffrey P. | Clot capture coil |
US6692508B2 (en) * | 1996-02-02 | 2004-02-17 | The Regents Of The University Of California | Method of using a clot capture coil |
US6248113B1 (en) * | 1996-06-20 | 2001-06-19 | Ernesto Fina | Device for the electrolytic dissolution of urinary stones and related method of treatment of urinary calculosis |
US6066158A (en) * | 1996-07-25 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot encasing and removal wire |
US6245089B1 (en) * | 1997-03-06 | 2001-06-12 | Scimed Life Systems, Inc. | Distal protection device and method |
US6053932A (en) * | 1997-03-06 | 2000-04-25 | Scimed Life Systems, Inc. | Distal protection device |
US20060129180A1 (en) * | 1997-05-08 | 2006-06-15 | Tsugita Ross S | Methods of protecting a patient from embolization during surgery |
US6066149A (en) * | 1997-09-30 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot treatment device with distal filter |
US20060095070A1 (en) * | 1997-11-07 | 2006-05-04 | Paul Gilson | Embolic portection device |
US6033394A (en) * | 1997-12-05 | 2000-03-07 | Intratherapeutics, Inc. | Catheter support structure |
US6695858B1 (en) * | 1998-02-10 | 2004-02-24 | Artemis Medical, Inc. | Medical device and methods for use |
US6221006B1 (en) * | 1998-02-10 | 2001-04-24 | Artemis Medical Inc. | Entrapping apparatus and method for use |
US6383195B1 (en) * | 1998-04-13 | 2002-05-07 | Endoline, Inc. | Laparoscopic specimen removal apparatus |
US6174318B1 (en) * | 1998-04-23 | 2001-01-16 | Scimed Life Systems, Inc. | Basket with one or more moveable legs |
US20040133232A1 (en) * | 1998-05-01 | 2004-07-08 | Microvention, Inc. | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders |
US6416505B1 (en) * | 1998-05-05 | 2002-07-09 | Scimed Life Systems, Inc. | Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and pressure application probe for use with same |
US20030060782A1 (en) * | 1998-06-04 | 2003-03-27 | Arani Bose | Endovascular thin film devices and methods for treating and preventing stroke |
US20030040771A1 (en) * | 1999-02-01 | 2003-02-27 | Hideki Hyodoh | Methods for creating woven devices |
US6409750B1 (en) * | 1999-02-01 | 2002-06-25 | Board Of Regents, The University Of Texas System | Woven bifurcated and trifurcated stents and methods for making the same |
US20050090857A1 (en) * | 1999-03-08 | 2005-04-28 | Ev3 Inc. | Minimally invasive medical device deployment and retrieval system |
US20030144687A1 (en) * | 1999-05-07 | 2003-07-31 | Salviac Limited | Support frame for an embolic protection device |
US6746468B1 (en) * | 1999-06-02 | 2004-06-08 | Concentric Medical, Inc. | Devices and methods for treating vascular malformations |
US7179273B1 (en) * | 1999-06-21 | 2007-02-20 | Endovascular Technologies, Inc. | Filter/emboli extractor for use in variable sized blood vessels |
US7235061B2 (en) * | 1999-08-03 | 2007-06-26 | Boston Scientific Scimed, Inc. | Guided filter with support wire and methods of use |
US6348056B1 (en) * | 1999-08-06 | 2002-02-19 | Scimed Life Systems, Inc. | Medical retrieval device with releasable retrieval basket |
US6425909B1 (en) * | 1999-11-04 | 2002-07-30 | Concentric Medical, Inc. | Methods and devices for filtering fluid flow through a body structure |
US6890341B2 (en) * | 1999-11-04 | 2005-05-10 | Concentric Medical, Inc. | Methods and devices for filtering fluid flow through a body structure |
US6190394B1 (en) * | 1999-11-05 | 2001-02-20 | Annex Medical, Inc. | Medical retrieval basket |
US6371971B1 (en) * | 1999-11-15 | 2002-04-16 | Scimed Life Systems, Inc. | Guidewire filter and methods of use |
US6745080B2 (en) * | 1999-11-22 | 2004-06-01 | Scimed Life Systems, Inc. | Helical and pre-oriented loop structures for supporting diagnostic and therapeutic elements in contact with body tissue |
US6872256B2 (en) * | 1999-12-17 | 2005-03-29 | Tokyo Electron Limited | Film forming unit |
US6592607B1 (en) * | 1999-12-23 | 2003-07-15 | Endovascular Technologies, Inc. | Snare |
US6575997B1 (en) * | 1999-12-23 | 2003-06-10 | Endovascular Technologies, Inc. | Embolic basket |
US20020026211A1 (en) * | 1999-12-23 | 2002-02-28 | Farhad Khosravi | Vascular device having emboli and thrombus removal element and methods of use |
US6402771B1 (en) * | 1999-12-23 | 2002-06-11 | Guidant Endovascular Solutions | Snare |
US7004956B2 (en) * | 1999-12-23 | 2006-02-28 | Endovascular Technologies, Inc. | Embolic basket |
US6685738B2 (en) * | 2000-01-31 | 2004-02-03 | Scimed Life Systems, Inc. | Braided endoluminal device having tapered filaments |
US6264664B1 (en) * | 2000-03-10 | 2001-07-24 | General Science And Technology Corp. | Surgical basket devices |
US6514273B1 (en) * | 2000-03-22 | 2003-02-04 | Endovascular Technologies, Inc. | Device for removal of thrombus through physiological adhesion |
US20050085849A1 (en) * | 2000-06-29 | 2005-04-21 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20050049619A1 (en) * | 2000-06-29 | 2005-03-03 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US6730104B1 (en) * | 2000-06-29 | 2004-05-04 | Concentric Medical, Inc. | Methods and devices for removing an obstruction from a blood vessel |
US20050059995A1 (en) * | 2000-06-29 | 2005-03-17 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20050125024A1 (en) * | 2000-06-29 | 2005-06-09 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20040073243A1 (en) * | 2000-06-29 | 2004-04-15 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20050033348A1 (en) * | 2000-06-29 | 2005-02-10 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US20020058904A1 (en) * | 2000-11-08 | 2002-05-16 | Robert Boock | Thrombus removal device |
US6679893B1 (en) * | 2000-11-16 | 2004-01-20 | Chestnut Medical Technologies, Inc. | Grasping device and method of use |
US6540657B2 (en) * | 2000-12-28 | 2003-04-01 | Scimed Life Systems, Inc. | Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance |
US7169165B2 (en) * | 2001-01-16 | 2007-01-30 | Boston Scientific Scimed, Inc. | Rapid exchange sheath for deployment of medical devices and methods of use |
US20050090858A1 (en) * | 2001-01-25 | 2005-04-28 | Ev3 Inc. | Distal protection device with electrospun polymer fiber matrix |
US6905503B2 (en) * | 2001-02-09 | 2005-06-14 | Concentric Medical, Inc. | Methods and devices for delivering occlusion elements |
US20040079429A1 (en) * | 2001-06-26 | 2004-04-29 | Concentric Medical, Inc. | Balloon catherer |
US6702782B2 (en) * | 2001-06-26 | 2004-03-09 | Concentric Medical, Inc. | Large lumen balloon catheter |
US20060004404A1 (en) * | 2001-06-28 | 2006-01-05 | Lithotech Medical Ltd. | Method for manufacturing a surgical device for extracting a foreign object |
US20030050663A1 (en) * | 2001-06-28 | 2003-03-13 | Stepan Khachin | Surgical device for retrieval of foreign objects from a body |
US20030023265A1 (en) * | 2001-07-13 | 2003-01-30 | Forber Simon John | Vascular protection system |
US6551342B1 (en) * | 2001-08-24 | 2003-04-22 | Endovascular Technologies, Inc. | Embolic filter |
US7004955B2 (en) * | 2001-08-24 | 2006-02-28 | Endovascular Technologies, Inc. | Embolic filter |
US6893431B2 (en) * | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
US20030093087A1 (en) * | 2001-11-15 | 2003-05-15 | Jones Donald K. | Embolic coil retrieval system |
US6755813B2 (en) * | 2001-11-20 | 2004-06-29 | Cleveland Clinic Foundation | Apparatus and method for performing thrombolysis |
US6749619B2 (en) * | 2001-11-20 | 2004-06-15 | The Cleveland Clinic Foundation | Apparatus and method for eliminating dislodged thrombus |
US7182771B1 (en) * | 2001-12-20 | 2007-02-27 | Russell A. Houser | Vascular couplers, techniques, methods, and accessories |
US7037320B2 (en) * | 2001-12-21 | 2006-05-02 | Salviac Limited | Support frame for an embolic protection device |
US7058456B2 (en) * | 2002-08-09 | 2006-06-06 | Concentric Medical, Inc. | Methods and devices for changing the shape of a medical device |
US20040066288A1 (en) * | 2002-09-24 | 2004-04-08 | Ryozo Okumura | Tire air pressure monitoring system |
US20040138692A1 (en) * | 2003-01-13 | 2004-07-15 | Scimed Life Systems, Inc. | Embolus extractor |
US20050004594A1 (en) * | 2003-07-02 | 2005-01-06 | Jeffrey Nool | Devices and methods for aspirating from filters |
US20050085847A1 (en) * | 2003-07-22 | 2005-04-21 | Galdonik Jason A. | Fiber based embolism protection device |
US20050043756A1 (en) * | 2003-07-31 | 2005-02-24 | Vance Products Incorporated D/B/A Cook Urological Incorporated | Ureteral backstop filter and retrieval device |
US20050038447A1 (en) * | 2003-08-12 | 2005-02-17 | Scimed Life Systems, Inc. | Laser-cut clot puller |
US20050055047A1 (en) * | 2003-09-04 | 2005-03-10 | Secant Medical, Llc | Endovascular snare for capture and removal of arterial emboli |
US20050131450A1 (en) * | 2003-12-15 | 2005-06-16 | Medtronic Vascular, Inc. | Embolic containment system with asymmetric frictional control |
US20060009784A1 (en) * | 2004-07-07 | 2006-01-12 | Percutaneous Systems, Inc. | Methods and apparatus for deploying conformed structures in body lumens |
US20060047286A1 (en) * | 2004-08-31 | 2006-03-02 | Stephen West | Clot retrieval device |
US20060129166A1 (en) * | 2004-12-15 | 2006-06-15 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Radiopaque manipulation devices |
US20090069828A1 (en) * | 2007-04-17 | 2009-03-12 | Lazarus Effect, Inc. | Articulating retrieval devices |
Cited By (203)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8632584B2 (en) | 2002-07-19 | 2014-01-21 | Dendron Gmbh | Medical implant having a curlable matrix structure and method of use |
US10342683B2 (en) | 2002-07-19 | 2019-07-09 | Ussc Medical Gmbh | Medical implant having a curlable matrix structure and method of use |
US11426293B2 (en) | 2002-07-19 | 2022-08-30 | Ussc Medical Gmbh | Medical implant |
US20070197103A1 (en) * | 2006-02-03 | 2007-08-23 | Martin Brian B | Devices for restoring blood flow within blocked vasculature |
US9931128B2 (en) | 2006-02-03 | 2018-04-03 | Covidien Lp | Methods for restoring blood flow within blocked vasculature |
US10806473B2 (en) | 2006-02-03 | 2020-10-20 | Covidien Lp | Methods for restoring blood flow within blocked vasculature |
US20070185501A1 (en) * | 2006-02-03 | 2007-08-09 | Martin Brian B | Devices for restoring blood flow within blocked vasculature |
US11596426B2 (en) | 2006-02-03 | 2023-03-07 | Covidien Lp | Methods for restoring blood flow within blocked vasculature |
US8298244B2 (en) | 2006-10-26 | 2012-10-30 | Tyco Healtcare Group Lp | Intracorporeal grasping device |
US10925625B2 (en) | 2007-04-17 | 2021-02-23 | Covidien Lp | Complex wire formed devices |
US11202646B2 (en) | 2007-04-17 | 2021-12-21 | Covidien Lp | Articulating retrieval devices |
US11617593B2 (en) | 2007-04-17 | 2023-04-04 | Covidien Lp | Complex wire formed devices |
US8535334B2 (en) | 2007-04-17 | 2013-09-17 | Lazarus Effect, Inc. | Complex wire formed devices |
US9271748B2 (en) | 2007-04-17 | 2016-03-01 | Lazarus Effect, Inc. | Complex wire formed devices |
US8512352B2 (en) | 2007-04-17 | 2013-08-20 | Lazarus Effect, Inc. | Complex wire formed devices |
US9271747B2 (en) | 2007-04-17 | 2016-03-01 | Lazarus Effect, Inc. | Complex wire formed devices |
US10064635B2 (en) | 2007-04-17 | 2018-09-04 | Covidien Lp | Articulating retrieval devices |
US10076346B2 (en) | 2007-04-17 | 2018-09-18 | Covidien Lp | Complex wire formed devices |
US9034007B2 (en) | 2007-09-21 | 2015-05-19 | Insera Therapeutics, Inc. | Distal embolic protection devices with a variable thickness microguidewire and methods for their use |
US11337714B2 (en) | 2007-10-17 | 2022-05-24 | Covidien Lp | Restoring blood flow and clot removal during acute ischemic stroke |
US10413310B2 (en) | 2007-10-17 | 2019-09-17 | Covidien Lp | Restoring blood flow and clot removal during acute ischemic stroke |
US11376027B2 (en) | 2007-12-26 | 2022-07-05 | Covidien Lp | Retrieval systems and methods for use thereof |
WO2009086482A1 (en) * | 2007-12-26 | 2009-07-09 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US8545526B2 (en) | 2007-12-26 | 2013-10-01 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US9717514B2 (en) | 2007-12-26 | 2017-08-01 | Covidien Lp | Retrieval systems and methods for use thereof |
CN102036611A (en) * | 2007-12-26 | 2011-04-27 | 拉撒路效应公司 | Retrieval systems and methods for use thereof |
US11529156B2 (en) | 2008-02-22 | 2022-12-20 | Covidien Lp | Methods and apparatus for flow restoration |
US8940003B2 (en) | 2008-02-22 | 2015-01-27 | Covidien Lp | Methods and apparatus for flow restoration |
US9161766B2 (en) | 2008-02-22 | 2015-10-20 | Covidien Lp | Methods and apparatus for flow restoration |
US10456151B2 (en) | 2008-02-22 | 2019-10-29 | Covidien Lp | Methods and apparatus for flow restoration |
US8679142B2 (en) | 2008-02-22 | 2014-03-25 | Covidien Lp | Methods and apparatus for flow restoration |
US20130144326A1 (en) * | 2008-07-22 | 2013-06-06 | Eamon Brady | Clot capture systems and associated methods |
WO2010010545A1 (en) * | 2008-07-22 | 2010-01-28 | Neuravi Limited | Clot capture systems and associated methods |
US8777976B2 (en) | 2008-07-22 | 2014-07-15 | Neuravi Limited | Clot capture systems and associated methods |
US9402707B2 (en) * | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
US10582939B2 (en) | 2008-07-22 | 2020-03-10 | Neuravi Limited | Clot capture systems and associated methods |
US20140379023A1 (en) * | 2008-07-22 | 2014-12-25 | Neuravi Limited | Clot capture systems and associated methods |
US11529157B2 (en) | 2008-07-22 | 2022-12-20 | Neuravi Limited | Clot capture systems and associated methods |
US10722255B2 (en) | 2008-12-23 | 2020-07-28 | Covidien Lp | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
US9254371B2 (en) | 2009-03-06 | 2016-02-09 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US10172633B2 (en) | 2009-03-06 | 2019-01-08 | Covidien Lp | Retrieval systems and methods for use thereof |
US8801748B2 (en) | 2010-01-22 | 2014-08-12 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US9924958B2 (en) | 2010-07-15 | 2018-03-27 | Covidien Lp | Retrieval systems and methods for use thereof |
US11051833B2 (en) | 2010-07-15 | 2021-07-06 | Covidien Lp | Retrieval systems and methods for use thereof |
US10426644B2 (en) | 2010-10-01 | 2019-10-01 | Covidien Lp | Methods and apparatuses for flow restoration and implanting members in the human body |
US9039749B2 (en) | 2010-10-01 | 2015-05-26 | Covidien Lp | Methods and apparatuses for flow restoration and implanting members in the human body |
US9351749B2 (en) | 2010-10-22 | 2016-05-31 | Neuravi Limited | Clot engagement and removal system |
US9463036B2 (en) | 2010-10-22 | 2016-10-11 | Neuravi Limited | Clot engagement and removal system |
US10292723B2 (en) | 2010-10-22 | 2019-05-21 | Neuravi Limited | Clot engagement and removal system |
US11246612B2 (en) | 2010-10-22 | 2022-02-15 | Neuravi Limited | Clot engagement and removal system |
US11871949B2 (en) | 2010-10-22 | 2024-01-16 | Neuravi Limited | Clot engagement and removal system |
US11259824B2 (en) | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US9301769B2 (en) | 2011-03-09 | 2016-04-05 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US9642639B2 (en) | 2011-03-09 | 2017-05-09 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US8852205B2 (en) | 2011-03-09 | 2014-10-07 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US10952760B2 (en) | 2011-03-09 | 2021-03-23 | Neuravi Limited | Clot retrieval device for removing a clot from a blood vessel |
US10034680B2 (en) | 2011-03-09 | 2018-07-31 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10292722B2 (en) | 2011-03-09 | 2019-05-21 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10743894B2 (en) | 2011-03-09 | 2020-08-18 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10299811B2 (en) | 2011-03-09 | 2019-05-28 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10588649B2 (en) | 2011-03-09 | 2020-03-17 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11213307B2 (en) | 2011-05-23 | 2022-01-04 | Covidien Lp | Retrieval systems and methods for use thereof |
US9943323B2 (en) | 2011-05-23 | 2018-04-17 | Covidien IP | Retrieval systems and methods for use thereof |
US9358094B2 (en) | 2011-05-23 | 2016-06-07 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US11529155B2 (en) | 2011-05-23 | 2022-12-20 | Covidien Lp | Retrieval systems and methods for use thereof |
US8932319B2 (en) | 2011-05-23 | 2015-01-13 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US8795305B2 (en) | 2011-05-23 | 2014-08-05 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
US20130110153A1 (en) * | 2011-10-26 | 2013-05-02 | Boston Scientific Scimed, Inc. | Extended protection embolic filter |
US8968354B2 (en) * | 2011-10-26 | 2015-03-03 | Boston Scientific Scimed, Inc. | Extended protection embolic filter |
US9358022B2 (en) * | 2012-05-21 | 2016-06-07 | Noha, Llc | Clot removal device and method of using same |
US10314600B2 (en) | 2012-05-21 | 2019-06-11 | Noha, Llc | Clot removal device and method of using same |
US20130310803A1 (en) * | 2012-05-21 | 2013-11-21 | Noha, Llc | Clot Removal Device and Method of Using Same |
US11246611B2 (en) | 2012-05-21 | 2022-02-15 | Hesham Morsi | Clot removal device and method of using same |
US9642635B2 (en) | 2013-03-13 | 2017-05-09 | Neuravi Limited | Clot removal device |
US10792055B2 (en) | 2013-03-13 | 2020-10-06 | Neuravi Limited | Clot removal device |
US10080575B2 (en) | 2013-03-13 | 2018-09-25 | Neuravi Limited | Clot removal device |
US10517622B2 (en) | 2013-03-13 | 2019-12-31 | Neuravi Limited | Clot removal device |
US10588648B2 (en) | 2013-03-14 | 2020-03-17 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10201360B2 (en) | 2013-03-14 | 2019-02-12 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US11103264B2 (en) | 2013-03-14 | 2021-08-31 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US9445829B2 (en) | 2013-03-14 | 2016-09-20 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
US10675045B2 (en) | 2013-03-14 | 2020-06-09 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10610246B2 (en) | 2013-03-14 | 2020-04-07 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11547427B2 (en) | 2013-03-14 | 2023-01-10 | Neuravi Limited | Clot retrieval devices |
US11839392B2 (en) | 2013-03-14 | 2023-12-12 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10420570B2 (en) | 2013-03-14 | 2019-09-24 | Neuravi Limited | Clot retrieval devices |
US10390850B2 (en) | 2013-03-14 | 2019-08-27 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10357265B2 (en) | 2013-03-14 | 2019-07-23 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US11937835B2 (en) | 2013-03-14 | 2024-03-26 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10278717B2 (en) | 2013-03-14 | 2019-05-07 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11871945B2 (en) | 2013-03-14 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US8789452B1 (en) | 2013-03-15 | 2014-07-29 | Insera Therapeutics, Inc. | Methods of manufacturing woven vascular treatment devices |
US8753371B1 (en) | 2013-03-15 | 2014-06-17 | Insera Therapeutics, Inc. | Woven vascular treatment systems |
US8904914B2 (en) | 2013-03-15 | 2014-12-09 | Insera Therapeutics, Inc. | Methods of using non-cylindrical mandrels |
US8910555B2 (en) | 2013-03-15 | 2014-12-16 | Insera Therapeutics, Inc. | Non-cylindrical mandrels |
US10251739B2 (en) | 2013-03-15 | 2019-04-09 | Insera Therapeutics, Inc. | Thrombus aspiration using an operator-selectable suction pattern |
US8721676B1 (en) | 2013-03-15 | 2014-05-13 | Insera Therapeutics, Inc. | Slotted vascular treatment devices |
US11298144B2 (en) | 2013-03-15 | 2022-04-12 | Insera Therapeutics, Inc. | Thrombus aspiration facilitation systems |
US9592068B2 (en) | 2013-03-15 | 2017-03-14 | Insera Therapeutics, Inc. | Free end vascular treatment systems |
US8715315B1 (en) | 2013-03-15 | 2014-05-06 | Insera Therapeutics, Inc. | Vascular treatment systems |
US8882797B2 (en) | 2013-03-15 | 2014-11-11 | Insera Therapeutics, Inc. | Methods of embolic filtering |
US9314324B2 (en) | 2013-03-15 | 2016-04-19 | Insera Therapeutics, Inc. | Vascular treatment devices and methods |
US9179995B2 (en) | 2013-03-15 | 2015-11-10 | Insera Therapeutics, Inc. | Methods of manufacturing slotted vascular treatment devices |
US10335260B2 (en) | 2013-03-15 | 2019-07-02 | Insera Therapeutics, Inc. | Methods of treating a thrombus in a vein using cyclical aspiration patterns |
US8715314B1 (en) | 2013-03-15 | 2014-05-06 | Insera Therapeutics, Inc. | Vascular treatment measurement methods |
US10342655B2 (en) | 2013-03-15 | 2019-07-09 | Insera Therapeutics, Inc. | Methods of treating a thrombus in an artery using cyclical aspiration patterns |
US8852227B1 (en) | 2013-03-15 | 2014-10-07 | Insera Therapeutics, Inc. | Woven radiopaque patterns |
US9179931B2 (en) | 2013-03-15 | 2015-11-10 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy systems |
US8733618B1 (en) | 2013-03-15 | 2014-05-27 | Insera Therapeutics, Inc. | Methods of coupling parts of vascular treatment systems |
US8747432B1 (en) | 2013-03-15 | 2014-06-10 | Insera Therapeutics, Inc. | Woven vascular treatment devices |
US8690907B1 (en) | 2013-03-15 | 2014-04-08 | Insera Therapeutics, Inc. | Vascular treatment methods |
US8895891B2 (en) | 2013-03-15 | 2014-11-25 | Insera Therapeutics, Inc. | Methods of cutting tubular devices |
US9750524B2 (en) | 2013-03-15 | 2017-09-05 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy systems |
US9901435B2 (en) | 2013-03-15 | 2018-02-27 | Insera Therapeutics, Inc. | Longitudinally variable vascular treatment devices |
US8721677B1 (en) | 2013-03-15 | 2014-05-13 | Insera Therapeutics, Inc. | Variably-shaped vascular devices |
US8783151B1 (en) | 2013-03-15 | 2014-07-22 | Insera Therapeutics, Inc. | Methods of manufacturing vascular treatment devices |
US10463468B2 (en) | 2013-03-15 | 2019-11-05 | Insera Therapeutics, Inc. | Thrombus aspiration with different intensity levels |
US8679150B1 (en) | 2013-03-15 | 2014-03-25 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy methods |
US9833251B2 (en) | 2013-03-15 | 2017-12-05 | Insera Therapeutics, Inc. | Variably bulbous vascular treatment devices |
US8795330B1 (en) | 2013-07-29 | 2014-08-05 | Insera Therapeutics, Inc. | Fistula flow disruptors |
US8784446B1 (en) | 2013-07-29 | 2014-07-22 | Insera Therapeutics, Inc. | Circumferentially offset variable porosity devices |
US8863631B1 (en) | 2013-07-29 | 2014-10-21 | Insera Therapeutics, Inc. | Methods of manufacturing flow diverting devices |
US8869670B1 (en) | 2013-07-29 | 2014-10-28 | Insera Therapeutics, Inc. | Methods of manufacturing variable porosity devices |
US8735777B1 (en) | 2013-07-29 | 2014-05-27 | Insera Therapeutics, Inc. | Heat treatment systems |
US8870901B1 (en) | 2013-07-29 | 2014-10-28 | Insera Therapeutics, Inc. | Two-way shape memory vascular treatment systems |
US8845678B1 (en) | 2013-07-29 | 2014-09-30 | Insera Therapeutics Inc. | Two-way shape memory vascular treatment methods |
US8828045B1 (en) | 2013-07-29 | 2014-09-09 | Insera Therapeutics, Inc. | Balloon catheters |
US8845679B1 (en) | 2013-07-29 | 2014-09-30 | Insera Therapeutics, Inc. | Variable porosity flow diverting devices |
US8715316B1 (en) | 2013-07-29 | 2014-05-06 | Insera Therapeutics, Inc. | Offset vascular treatment devices |
US10390926B2 (en) | 2013-07-29 | 2019-08-27 | Insera Therapeutics, Inc. | Aspiration devices and methods |
US8715317B1 (en) | 2013-07-29 | 2014-05-06 | Insera Therapeutics, Inc. | Flow diverting devices |
US10751159B2 (en) | 2013-07-29 | 2020-08-25 | Insera Therapeutics, Inc. | Systems for aspirating thrombus during neurosurgical procedures |
US8932321B1 (en) | 2013-07-29 | 2015-01-13 | Insera Therapeutics, Inc. | Aspiration systems |
US8872068B1 (en) | 2013-07-29 | 2014-10-28 | Insera Therapeutics, Inc. | Devices for modifying hypotubes |
US8859934B1 (en) | 2013-07-29 | 2014-10-14 | Insera Therapeutics, Inc. | Methods for slag removal |
US8932320B1 (en) | 2013-07-29 | 2015-01-13 | Insera Therapeutics, Inc. | Methods of aspirating thrombi |
US8813625B1 (en) | 2013-07-29 | 2014-08-26 | Insera Therapeutics, Inc. | Methods of manufacturing variable porosity flow diverting devices |
US8790365B1 (en) | 2013-07-29 | 2014-07-29 | Insera Therapeutics, Inc. | Fistula flow disruptor methods |
US8866049B1 (en) | 2013-07-29 | 2014-10-21 | Insera Therapeutics, Inc. | Methods of selectively heat treating tubular devices |
US8728116B1 (en) | 2013-07-29 | 2014-05-20 | Insera Therapeutics, Inc. | Slotted catheters |
US8870910B1 (en) | 2013-07-29 | 2014-10-28 | Insera Therapeutics, Inc. | Methods of decoupling joints |
US8728117B1 (en) | 2013-07-29 | 2014-05-20 | Insera Therapeutics, Inc. | Flow disrupting devices |
US8803030B1 (en) | 2013-07-29 | 2014-08-12 | Insera Therapeutics, Inc. | Devices for slag removal |
US8816247B1 (en) | 2013-07-29 | 2014-08-26 | Insera Therapeutics, Inc. | Methods for modifying hypotubes |
US11304712B2 (en) | 2013-09-13 | 2022-04-19 | Covidien Lp | Endovascular device engagement |
US10076399B2 (en) | 2013-09-13 | 2018-09-18 | Covidien Lp | Endovascular device engagement |
US10285720B2 (en) | 2014-03-11 | 2019-05-14 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11484328B2 (en) | 2014-03-11 | 2022-11-01 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US10682152B2 (en) | 2014-06-13 | 2020-06-16 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US11446045B2 (en) | 2014-06-13 | 2022-09-20 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10441301B2 (en) | 2014-06-13 | 2019-10-15 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10792056B2 (en) | 2014-06-13 | 2020-10-06 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US11076876B2 (en) | 2014-06-30 | 2021-08-03 | Neuravi Limited | System for removing a clot from a blood vessel |
US20150374479A1 (en) * | 2014-06-30 | 2015-12-31 | Neuravi Limited | System for removing a clot from a blood vessel |
US10265086B2 (en) * | 2014-06-30 | 2019-04-23 | Neuravi Limited | System for removing a clot from a blood vessel |
US11944333B2 (en) | 2014-06-30 | 2024-04-02 | Neuravi Limited | System for removing a clot from a blood vessel |
US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11857210B2 (en) | 2014-11-26 | 2024-01-02 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11712256B2 (en) | 2014-11-26 | 2023-08-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US10363054B2 (en) | 2014-11-26 | 2019-07-30 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US11253278B2 (en) | 2014-11-26 | 2022-02-22 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11497895B2 (en) | 2015-02-11 | 2022-11-15 | Covidien Lp | Expandable tip medical devices and methods |
US10456560B2 (en) | 2015-02-11 | 2019-10-29 | Covidien Lp | Expandable tip medical devices and methods |
US11395667B2 (en) | 2016-08-17 | 2022-07-26 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11147572B2 (en) | 2016-09-06 | 2021-10-19 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US11129630B2 (en) | 2017-05-12 | 2021-09-28 | Covidien Lp | Retrieval of material from vessel lumens |
US11684379B2 (en) | 2017-05-12 | 2023-06-27 | Covidien Lp | Retrieval of material from vessel lumens |
US11298145B2 (en) | 2017-05-12 | 2022-04-12 | Covidien Lp | Retrieval of material from vessel lumens |
US10722257B2 (en) | 2017-05-12 | 2020-07-28 | Covidien Lp | Retrieval of material from vessel lumens |
US11191555B2 (en) | 2017-05-12 | 2021-12-07 | Covidien Lp | Retrieval of material from vessel lumens |
US10709464B2 (en) | 2017-05-12 | 2020-07-14 | Covidien Lp | Retrieval of material from vessel lumens |
US11596427B2 (en) | 2017-06-12 | 2023-03-07 | Covidien Lp | Tools for sheathing treatment devices and associated systems and methods |
US10945746B2 (en) | 2017-06-12 | 2021-03-16 | Covidien Lp | Tools for sheathing treatment devices and associated systems and methods |
US11304834B2 (en) | 2017-06-19 | 2022-04-19 | Covidien Lp | Retractor device for transforming a retrieval device from a deployed position to a delivery position |
US10478322B2 (en) | 2017-06-19 | 2019-11-19 | Covidien Lp | Retractor device for transforming a retrieval device from a deployed position to a delivery position |
US10575864B2 (en) | 2017-06-22 | 2020-03-03 | Covidien Lp | Securing element for resheathing an intravascular device and associated systems and methods |
US11497513B2 (en) | 2017-06-22 | 2022-11-15 | Covidien Lp | Securing element for resheathing an intravascular device and associated systems and methods |
US10842498B2 (en) | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
US11963693B2 (en) | 2018-10-02 | 2024-04-23 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
US11311304B2 (en) | 2019-03-04 | 2022-04-26 | Neuravi Limited | Actuated clot retrieval catheter |
US11529495B2 (en) | 2019-09-11 | 2022-12-20 | Neuravi Limited | Expandable mouth catheter |
US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
US11779364B2 (en) | 2019-11-27 | 2023-10-10 | Neuravi Limited | Actuated expandable mouth thrombectomy catheter |
US11839725B2 (en) | 2019-11-27 | 2023-12-12 | Neuravi Limited | Clot retrieval device with outer sheath and inner catheter |
US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
US11944327B2 (en) | 2020-03-05 | 2024-04-02 | Neuravi Limited | Expandable mouth aspirating clot retrieval catheter |
US11633198B2 (en) | 2020-03-05 | 2023-04-25 | Neuravi Limited | Catheter proximal joint |
US11883043B2 (en) | 2020-03-31 | 2024-01-30 | DePuy Synthes Products, Inc. | Catheter funnel extension |
US11759217B2 (en) | 2020-04-07 | 2023-09-19 | Neuravi Limited | Catheter tubular support |
US11730501B2 (en) | 2020-04-17 | 2023-08-22 | Neuravi Limited | Floating clot retrieval device for removing clots from a blood vessel |
US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11717308B2 (en) | 2020-04-17 | 2023-08-08 | Neuravi Limited | Clot retrieval device for removing heterogeneous clots from a blood vessel |
US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
US11937836B2 (en) | 2020-06-22 | 2024-03-26 | Neuravi Limited | Clot retrieval system with expandable clot engaging framework |
US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11395669B2 (en) | 2020-06-23 | 2022-07-26 | Neuravi Limited | Clot retrieval device with flexible collapsible frame |
US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
US11937837B2 (en) | 2020-12-29 | 2024-03-26 | Neuravi Limited | Fibrin rich / soft clot mechanical thrombectomy device |
US11872354B2 (en) | 2021-02-24 | 2024-01-16 | Neuravi Limited | Flexible catheter shaft frame with seam |
US11937839B2 (en) | 2021-09-28 | 2024-03-26 | Neuravi Limited | Catheter with electrically actuated expandable mouth |
US11969180B2 (en) | 2022-04-14 | 2024-04-30 | Neuravi Limited | Actuated clot retrieval catheter |
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WO2007092820A2 (en) | 2007-08-16 |
US20180228504A1 (en) | 2018-08-16 |
EP1986568A2 (en) | 2008-11-05 |
WO2007092820A3 (en) | 2008-01-24 |
EP1986568B1 (en) | 2017-04-05 |
US20070185500A1 (en) | 2007-08-09 |
US20070185501A1 (en) | 2007-08-09 |
US9931128B2 (en) | 2018-04-03 |
US20070198029A1 (en) | 2007-08-23 |
US20070198030A1 (en) | 2007-08-23 |
US10806473B2 (en) | 2020-10-20 |
US11596426B2 (en) | 2023-03-07 |
US20200405336A1 (en) | 2020-12-31 |
US20140188143A1 (en) | 2014-07-03 |
EP1986568A4 (en) | 2012-12-05 |
US20070197103A1 (en) | 2007-08-23 |
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