US20070005030A1 - Aspiration control via flow or impedance - Google Patents

Aspiration control via flow or impedance Download PDF

Info

Publication number
US20070005030A1
US20070005030A1 US11/158,259 US15825905A US2007005030A1 US 20070005030 A1 US20070005030 A1 US 20070005030A1 US 15825905 A US15825905 A US 15825905A US 2007005030 A1 US2007005030 A1 US 2007005030A1
Authority
US
United States
Prior art keywords
flow rate
response
aspiration
aspiration chamber
suction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/158,259
Inventor
Mark Hopkins
John Huculak
Kirk Todd
Roger Thomas
Shawn Gao
Nader Nazarifar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Priority to US11/158,259 priority Critical patent/US20070005030A1/en
Priority to US11/158,238 priority patent/US7524299B2/en
Assigned to ALCON, INC. reassignment ALCON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HUCULAK, JOHN C., NAZARIFAR, NADER, GAO, SHAWN X., HOPKINS, MARK A., THOMAS, ROGER, TODD, KIRK W.
Priority to PCT/US2006/005957 priority patent/WO2007001503A2/en
Priority to AU2006262933A priority patent/AU2006262933B2/en
Priority to ES06720911T priority patent/ES2344921T3/en
Priority to SI200630583T priority patent/SI1893251T1/en
Priority to CA2608633A priority patent/CA2608633C/en
Priority to DE602006014967T priority patent/DE602006014967D1/en
Priority to EP06720912A priority patent/EP1893251B1/en
Priority to PL06720912T priority patent/PL1893251T3/en
Priority to JP2008518129A priority patent/JP5080460B2/en
Priority to CA2608591A priority patent/CA2608591C/en
Priority to PCT/US2006/005956 priority patent/WO2007001502A2/en
Priority to DE602006011613T priority patent/DE602006011613D1/en
Priority to ES06720912T priority patent/ES2338147T3/en
Priority to AT06720911T priority patent/ATE471172T1/en
Priority to PT06720912T priority patent/PT1893251E/en
Priority to JP2008518130A priority patent/JP5080461B2/en
Priority to AT06720912T priority patent/ATE454175T1/en
Priority to AU2006262932A priority patent/AU2006262932B2/en
Priority to DK06720912.2T priority patent/DK1893251T3/en
Priority to EP06720911A priority patent/EP1893250B1/en
Priority to ARP060101104A priority patent/AR056946A1/en
Priority to ARP060101105A priority patent/AR056947A1/en
Priority to US11/491,630 priority patent/US7594901B2/en
Publication of US20070005030A1 publication Critical patent/US20070005030A1/en
Priority to US12/545,392 priority patent/US8246580B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/72—Cassettes forming partially or totally the fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/73—Suction drainage systems comprising sensors or indicators for physical values
    • A61M1/732—Visual indicating means for vacuum pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/74—Suction control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/74—Suction control
    • A61M1/743—Suction control by changing the cross-section of the line, e.g. flow regulating valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/80—Suction pumps
    • A61M1/804—Suction pumps using Laval or Venturi jet pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates

Definitions

  • the present invention generally pertains to controlling aspiration in microsurgical systems and more particularly to controlling aspiration in ophthalmic microsurgical systems.
  • small probes are inserted into the operative site to cut, remove, or otherwise manipulate tissue.
  • fluid is typically infused into the eye, and the infusion fluid and tissue are aspirated from the surgical site. Varying surgical conditions and surgical objectives can lead to varying amounts of effort required to effectively and safely remove the tissue and fluid.
  • aspiration systems prior to the present invention, were generally characterized as either flow controlled or vacuum controlled, depending upon the type of pump used in the system. Each type of system has certain advantages.
  • Vacuum controlled aspiration systems are operated by setting a desired vacuum level, which the system seeks to maintain. Flow rate is dependent on intraocular pressure, vacuum level, and resistance to flow in the fluid path. Actual flow rate information is unavailable. Vacuum controlled aspiration systems typically use a venturi or diaphragm pump. Vacuum controlled aspiration systems offer the advantages of quick response times, control of decreasing vacuum levels, and good fluidic performance while aspirating air, such as during an air/fluid exchange procedure. Disadvantages of such systems are the lack of flow information resulting in transient high flows during phacoemulsification or fragmentation coupled with a lack of occlusion detection. Vacuum controlled systems are difficult to operate in a flow controlled mode because of the problems of non-invasively measuring flow in real time.
  • Flow controlled aspiration systems are operated by setting a desired aspiration flow rate for the system to maintain.
  • Flow controlled aspiration systems typically use a peristaltic, scroll, or vane pump.
  • Flow controlled aspiration systems offer the advantages of stable flow rates and automatically increasing vacuum levels under occlusion. Disadvantages of such systems are relatively slow response times, undesired occlusion break responses when large compliant components are used, and vacuum can not be linearly decreased during tip occlusion.
  • Flow controlled systems are difficult to operate in a vacuum controlled mode because time delays in measuring vacuum can cause instability in the control loop, reducing dynamic performance.
  • MILLENIUM system contains both a vacuum controlled aspiration system (using a venturi pump) and a separate flow controlled aspiration system (using a scroll pump).
  • the two pumps can not be used simultaneously, and each pump requires separate aspiration tubing and cassette.
  • ACCURUS® system contains both a venturi pump and a peristaltic pump that operate in series.
  • the venturi pump aspirates material from the surgical site to a small collection chamber.
  • the peristaltic pump pumps the aspirate from the small collection chamber to a larger collection bag.
  • the peristaltic pump does not provide aspiration vacuum to the surgical site.
  • the system operates as a vacuum controlled system.
  • the present invention is a method of controlling aspiration in a microsurgical system.
  • a desired suction flow rate is created in an aspiration chamber using a pressurized gas source, a vacuum generator, and a pump.
  • Fluid is aspirated from a surgical device into the aspiration chamber.
  • An actual level of the fluid is determined in the aspiration chamber.
  • a suction flow rate is calculated in response to the actual level of fluid.
  • a change in the suction flow rate is monitored to detect an occlusion.
  • a suction impedance is calculated in response to the suction flow rate.
  • a change in the suction impedance is monitored to detect an occlusion.
  • FIG. 1 is a schematic diagram illustrating aspiration control in a microsurgical system.
  • Microsurgical system 10 includes a pressurized gas source 12 , an isolation valve 14 , a vacuum proportional valve 16 , an optional second vacuum proportional valve 18 , a pressure proportional valve 20 , a vacuum generator 22 , a pressure transducer 24 , an aspiration chamber 26 , a fluid level sensor 28 , a pump 30 , a collection bag 32 , an aspiration port 34 , a surgical device 36 , a computer or microprocessor 38 , and a proportional control device 40 .
  • the various components of system 10 are fluidly coupled via fluid lines 44 , 46 , 48 , 50 , 52 , 54 , 56 , and 58 .
  • Valve 14 is preferably an “on/off” solenoid valve.
  • Valves 16 - 20 are preferably proportional solenoid valves.
  • Vacuum generator 22 may be any suitable device for generating vacuum but is preferably a vacuum chip or a venturi chip that generates vacuum when isolation valve 14 and vacuum proportional valves 16 and/or 18 are open and gas from pressurized gas source 12 is passed through vacuum generator 22 .
  • Pressure transducer 24 may be any suitable device for directly or indirectly measuring pressure and vacuum.
  • Fluid level sensor 28 may be any suitable device for measuring the level of a fluid 42 within aspiration chamber 26 but is preferably capable of measuring fluid levels in a continuous manner.
  • Pump 30 may be any suitable device for generating vacuum but is preferably a peristaltic pump, a scroll pump, or a vane pump.
  • Microprocessor 38 is capable of implementing feedback control, and preferably PID control.
  • Proportional controller 40 may be any suitable device for proportionally controlling system 10 and/or surgical device 36 but is preferably a foot controller.
  • System 10 preferably utilizes three distinct methods of controlling aspiration, vacuum control, suction control, and flow control.
  • microprocessor 38 activates isolation valve 14 via interface 66 and maintains pressure valve 20 in a closed state via interface 70 .
  • Proportional controller 40 and microprocessor 38 are used to proportionally open or close vacuum proportional valve 16 (and optionally vacuum proportional valve 18 , for higher levels of vacuum) via interfaces 60 , 64 , and 68 .
  • a surgeon inputs a maximum vacuum level into microprocessor 38 .
  • proportional controller 40 the surgeon may then proportionally vary the desired vacuum provided to surgical device 36 and aspiration chamber 26 via vacuum generator 22 between zero and the maximum value.
  • pressure transducer 24 measures the actual vacuum in aspiration chamber 26 and provides a corresponding signal to microprocessor 38 via interface 72 .
  • Microprocessor 38 in turn provides feedback signals to valves 16 and 18 via interfaces 64 and 68 to maintain the vacuum at the desired level indicated by proportional controller 40 .
  • microprocessor 38 activates valves 14 , 16 , 18 , and 20 .
  • System 10 is configured to provide a range of suction to surgical device 36 and aspiration chamber 26 from a small positive value of pressure to a larger negative value of pressure (or vacuum). This range is preferably from about +150 mm Hg to about ⁇ 650 mm Hg.
  • proportional controller 40 a surgeon may proportionally vary the desired suction provided to surgical device 36 and aspiration chamber 26 via pressurized gas source 12 and vacuum generator 22 in this range.
  • a signal corresponding to the desired suction is provided to microprocessor 38 via interface 60 .
  • Pressure transducer 24 provides a signal corresponding to the actual suction pressure in aspiration chamber 26 to microprocessor 38 via interface 72 .
  • Microprocessor 38 then provides feedback signals to any combination of valves 16 , 18 , and 20 via interfaces 64 , 68 , and 70 , respectively, to maintain the suction within aspiration chamber 26 and surgical device 36 at the desired level.
  • the suction control mode allows microprocessor 38 to close valves 16 and 18 and open valve 20 to create a pressure within aspiration chamber 26 equal to the intraocular pressure so as to prevent passive flow from the eye into surgical device 36 and aspiration chamber 26 .
  • microprocessor 38 activates valves 14 , 16 , 18 , and 20 .
  • System 10 is configured to provide a range of flow to surgical device 36 and aspiration chamber 26 from a value of zero flow to a maximum value of flow.
  • proportional controller 40 a surgeon may proportionally vary the desired suction flow rate for surgical device 36 and aspiration chamber 26 in this range.
  • Q suction Q pump ( N,P )+ A dz/dt
  • Q suction is the suction flow rate
  • Q pump is the flow rate of pump 30
  • N is the speed of pump 30
  • P is the suction pressure measured by pressure transducer 24
  • A is the cross-sectional area of aspiration chamber 26
  • Z is the level of fluid 42 in aspiration chamber 26 measured via fluid level sensor 28 .
  • a signal corresponding to the desired Q suction is provided to microprocessor 38 via interface 60 .
  • Microprocessor 38 provides a signal corresponding to pump speed N to pump 30 via interface 74 in response to the desired Q suction .
  • Fluid level sensor 28 provides a signal corresponding to the actual level of fluid within aspiration chamber 26 to microprocessor 38 via interface 76 .
  • Microprocessor 38 uses the suction control mode, as described above, to maintain Q suction at the desired level. More specifically, microprocessor 38 calculates Q suction in response to the actual level of fluid within aspiration chamber 26 and provides feedback signals to any combination of valves 16 , 18 , and 20 via interfaces 64 , 68 , and 70 , respectively, so as to maintain Q suction at the desired level.
  • pressure transducer 24 provides a signal corresponding to the actual suction pressure P in aspiration chamber 26 to microprocessor 38 via interface 72 .
  • I ( P suction ⁇ P reference )/ Q suction
  • I is the suction impedance
  • Q suction is the suction flow rate
  • P suction is the suction pressure P measured by pressure transducer 24
  • P reference is a reference pressure, such as intraocular pressure in an aspiration circuit of a microsurgical system, or infusion pressure, irrigation pressure, or atmospheric pressure in the infusion circuit of a microsurgical system.
  • traditional vacuum controlled aspiration systems are not capable of occlusion detection in the aspiration circuit, and traditional flow
  • monitoring change in Q suction or I is a more effective and safe way of detecting occlusion in an aspiration circuit of a microsurgical system. Detecting occlusion by monitoring change in Q suction or I gives a surgeon a better idea of the characteristics of the material that is causing the occlusion. Monitoring change in I is believed to be preferred over monitoring change in Q suction . Preferably, microprocessor 38 monitors such change in Q suction or I in real time.
  • microprocessor 38 may automatically adjust other surgical parameters in order to improve the speed and safety of the surgical procedure. For example, if surgical device 36 is a phacoemulsification probe, ultrasound energy, desired suction pressure, desired suction flow rate, and/or infusion pressure may be adjusted real-time as either Q suction or I changes. As another example, if surgical device 36 is a vitrectomy probe, cut rate, port open duty cycle, desired suction pressure, desired suction flow rate, and/or infusion pressure may be adjusted real time as either Q suction or I changes. In addition, microprocessor 38 may use changes in I to communicate fluid or tissue properties such as viscosity to the surgeon via an appropriate sense (e.g. audibly, visually, or tactilely).
  • fluid or tissue properties such as viscosity
  • the present invention is illustrated herein by example, and various modifications may be made by a person of ordinary skill in the art.
  • the present invention is described above relative to detecting occlusion in the aspiration circuit of a microsurgical system, it is also applicable to detecting occlusion in the infusion circuit of a microsurgical system.

Abstract

A microsurgical system capable of controlling aspiration and detecting an occlusion via monitoring a change in either suction flow rate or suction impedance.

Description

    FIELD OF THE INVENTION
  • The present invention generally pertains to controlling aspiration in microsurgical systems and more particularly to controlling aspiration in ophthalmic microsurgical systems.
    • DESCRIPTION OF THE RELATED ART
  • During small incision surgery, and particularly during ophthalmic surgery, small probes are inserted into the operative site to cut, remove, or otherwise manipulate tissue. During these surgical procedures, fluid is typically infused into the eye, and the infusion fluid and tissue are aspirated from the surgical site. Varying surgical conditions and surgical objectives can lead to varying amounts of effort required to effectively and safely remove the tissue and fluid.
  • The types of aspiration systems used, prior to the present invention, were generally characterized as either flow controlled or vacuum controlled, depending upon the type of pump used in the system. Each type of system has certain advantages.
  • Vacuum controlled aspiration systems are operated by setting a desired vacuum level, which the system seeks to maintain. Flow rate is dependent on intraocular pressure, vacuum level, and resistance to flow in the fluid path. Actual flow rate information is unavailable. Vacuum controlled aspiration systems typically use a venturi or diaphragm pump. Vacuum controlled aspiration systems offer the advantages of quick response times, control of decreasing vacuum levels, and good fluidic performance while aspirating air, such as during an air/fluid exchange procedure. Disadvantages of such systems are the lack of flow information resulting in transient high flows during phacoemulsification or fragmentation coupled with a lack of occlusion detection. Vacuum controlled systems are difficult to operate in a flow controlled mode because of the problems of non-invasively measuring flow in real time.
  • Flow controlled aspiration systems are operated by setting a desired aspiration flow rate for the system to maintain. Flow controlled aspiration systems typically use a peristaltic, scroll, or vane pump. Flow controlled aspiration systems offer the advantages of stable flow rates and automatically increasing vacuum levels under occlusion. Disadvantages of such systems are relatively slow response times, undesired occlusion break responses when large compliant components are used, and vacuum can not be linearly decreased during tip occlusion. Flow controlled systems are difficult to operate in a vacuum controlled mode because time delays in measuring vacuum can cause instability in the control loop, reducing dynamic performance.
  • One currently available ophthalmic surgical system, the MILLENIUM system from Storz Instrument Company, contains both a vacuum controlled aspiration system (using a venturi pump) and a separate flow controlled aspiration system (using a scroll pump). The two pumps can not be used simultaneously, and each pump requires separate aspiration tubing and cassette.
  • Another currently available ophthalmic surgical system, the ACCURUS® system from Alcon Laboratories, Inc., contains both a venturi pump and a peristaltic pump that operate in series. The venturi pump aspirates material from the surgical site to a small collection chamber. The peristaltic pump pumps the aspirate from the small collection chamber to a larger collection bag. The peristaltic pump does not provide aspiration vacuum to the surgical site. Thus, the system operates as a vacuum controlled system.
  • Accordingly, a need continues to exist for an improved method of effectively and safely removing aspirated tissue and fluid in a microsurgical system.
    • SUMMARY OF THE INVENTION
  • The present invention is a method of controlling aspiration in a microsurgical system. A desired suction flow rate is created in an aspiration chamber using a pressurized gas source, a vacuum generator, and a pump. Fluid is aspirated from a surgical device into the aspiration chamber. An actual level of the fluid is determined in the aspiration chamber.
  • In one aspect of the present invention, a suction flow rate is calculated in response to the actual level of fluid. A change in the suction flow rate is monitored to detect an occlusion.
  • In another aspect of the present invention, a suction impedance is calculated in response to the suction flow rate. A change in the suction impedance is monitored to detect an occlusion.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • For a more complete understanding of the present invention, and for further objects and advantages thereof, reference is made to the following description taken in conjunction with the accompanying drawing, in which FIG. 1 is a schematic diagram illustrating aspiration control in a microsurgical system.
    • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The preferred embodiment of the present invention and its advantages is best understood by referring to FIG. 1 of the drawings. Microsurgical system 10 includes a pressurized gas source 12, an isolation valve 14, a vacuum proportional valve 16, an optional second vacuum proportional valve 18, a pressure proportional valve 20, a vacuum generator 22, a pressure transducer 24, an aspiration chamber 26, a fluid level sensor 28, a pump 30, a collection bag 32, an aspiration port 34, a surgical device 36, a computer or microprocessor 38, and a proportional control device 40. The various components of system 10 are fluidly coupled via fluid lines 44, 46, 48, 50, 52, 54, 56, and 58. The various components of system 10 are electrically coupled via interfaces 60, 62, 64, 66, 68, 70, 72, 74, and 76. Valve 14 is preferably an “on/off” solenoid valve. Valves 16-20 are preferably proportional solenoid valves. Vacuum generator 22 may be any suitable device for generating vacuum but is preferably a vacuum chip or a venturi chip that generates vacuum when isolation valve 14 and vacuum proportional valves 16 and/or 18 are open and gas from pressurized gas source 12 is passed through vacuum generator 22. Pressure transducer 24 may be any suitable device for directly or indirectly measuring pressure and vacuum. Fluid level sensor 28 may be any suitable device for measuring the level of a fluid 42 within aspiration chamber 26 but is preferably capable of measuring fluid levels in a continuous manner. Pump 30 may be any suitable device for generating vacuum but is preferably a peristaltic pump, a scroll pump, or a vane pump. Microprocessor 38 is capable of implementing feedback control, and preferably PID control. Proportional controller 40 may be any suitable device for proportionally controlling system 10 and/or surgical device 36 but is preferably a foot controller.
  • System 10 preferably utilizes three distinct methods of controlling aspiration, vacuum control, suction control, and flow control. In vacuum control mode, microprocessor 38 activates isolation valve 14 via interface 66 and maintains pressure valve 20 in a closed state via interface 70. Proportional controller 40 and microprocessor 38 are used to proportionally open or close vacuum proportional valve 16 (and optionally vacuum proportional valve 18, for higher levels of vacuum) via interfaces 60, 64, and 68. A surgeon inputs a maximum vacuum level into microprocessor 38. Using proportional controller 40, the surgeon may then proportionally vary the desired vacuum provided to surgical device 36 and aspiration chamber 26 via vacuum generator 22 between zero and the maximum value. As aspiration chamber 26 fills with fluid 42 aspirated by surgical device 36, pressure transducer 24 measures the actual vacuum in aspiration chamber 26 and provides a corresponding signal to microprocessor 38 via interface 72. Microprocessor 38 in turn provides feedback signals to valves 16 and 18 via interfaces 64 and 68 to maintain the vacuum at the desired level indicated by proportional controller 40.
  • In the suction control mode, microprocessor 38 activates valves 14, 16, 18, and 20. System 10 is configured to provide a range of suction to surgical device 36 and aspiration chamber 26 from a small positive value of pressure to a larger negative value of pressure (or vacuum). This range is preferably from about +150 mm Hg to about −650 mm Hg. Using proportional controller 40, a surgeon may proportionally vary the desired suction provided to surgical device 36 and aspiration chamber 26 via pressurized gas source 12 and vacuum generator 22 in this range. A signal corresponding to the desired suction is provided to microprocessor 38 via interface 60. Pressure transducer 24 provides a signal corresponding to the actual suction pressure in aspiration chamber 26 to microprocessor 38 via interface 72. Microprocessor 38 then provides feedback signals to any combination of valves 16, 18, and 20 via interfaces 64, 68, and 70, respectively, to maintain the suction within aspiration chamber 26 and surgical device 36 at the desired level. As one skilled in the art will appreciate, the suction control mode allows microprocessor 38 to close valves 16 and 18 and open valve 20 to create a pressure within aspiration chamber 26 equal to the intraocular pressure so as to prevent passive flow from the eye into surgical device 36 and aspiration chamber 26.
  • In the flow control mode, microprocessor 38 activates valves 14, 16, 18, and 20. System 10 is configured to provide a range of flow to surgical device 36 and aspiration chamber 26 from a value of zero flow to a maximum value of flow. Using proportional controller 40, a surgeon may proportionally vary the desired suction flow rate for surgical device 36 and aspiration chamber 26 in this range. Flow rate is calculated using the following equation:
    Q suction =Q pump(N,P)+A dz/dt,
    where Qsuction is the suction flow rate, Qpump is the flow rate of pump 30, N is the speed of pump 30, P is the suction pressure measured by pressure transducer 24, A is the cross-sectional area of aspiration chamber 26, and Z is the level of fluid 42 in aspiration chamber 26 measured via fluid level sensor 28. A signal corresponding to the desired Qsuction is provided to microprocessor 38 via interface 60. Microprocessor 38 provides a signal corresponding to pump speed N to pump 30 via interface 74 in response to the desired Qsuction. Fluid level sensor 28 provides a signal corresponding to the actual level of fluid within aspiration chamber 26 to microprocessor 38 via interface 76. Microprocessor 38 uses the suction control mode, as described above, to maintain Qsuction at the desired level. More specifically, microprocessor 38 calculates Qsuction in response to the actual level of fluid within aspiration chamber 26 and provides feedback signals to any combination of valves 16, 18, and 20 via interfaces 64, 68, and 70, respectively, so as to maintain Qsuction at the desired level. As part of the suction control mode, pressure transducer 24 provides a signal corresponding to the actual suction pressure P in aspiration chamber 26 to microprocessor 38 via interface 72. As one skilled in the art will appreciate, the flow control mode allows microprocessor 38 to maintain a constant level of fluid 42 in aspiration chamber 26 (dz/dt=0) so as to maintain flow rate.
  • In the suction control mode, suction impedance can be defined as follows:
    I=(P suction −P reference)/Q suction,
    where I is the suction impedance, Qsuction is the suction flow rate, Psuction is the suction pressure P measured by pressure transducer 24, and Preference is a reference pressure, such as intraocular pressure in an aspiration circuit of a microsurgical system, or infusion pressure, irrigation pressure, or atmospheric pressure in the infusion circuit of a microsurgical system. As discussed hereinabove, traditional vacuum controlled aspiration systems are not capable of occlusion detection in the aspiration circuit, and traditional flow based aspiration systems detect occlusion in the aspiration circuit by monitoring change in measured vacuum. It has been discovered that monitoring change in Qsuction or I is a more effective and safe way of detecting occlusion in an aspiration circuit of a microsurgical system. Detecting occlusion by monitoring change in Qsuction or I gives a surgeon a better idea of the characteristics of the material that is causing the occlusion. Monitoring change in I is believed to be preferred over monitoring change in Qsuction. Preferably, microprocessor 38 monitors such change in Qsuction or I in real time.
  • Once an occlusion is detected by monitoring change in Qsuction or I, microprocessor 38 may automatically adjust other surgical parameters in order to improve the speed and safety of the surgical procedure. For example, if surgical device 36 is a phacoemulsification probe, ultrasound energy, desired suction pressure, desired suction flow rate, and/or infusion pressure may be adjusted real-time as either Qsuction or I changes. As another example, if surgical device 36 is a vitrectomy probe, cut rate, port open duty cycle, desired suction pressure, desired suction flow rate, and/or infusion pressure may be adjusted real time as either Qsuction or I changes. In addition, microprocessor 38 may use changes in I to communicate fluid or tissue properties such as viscosity to the surgeon via an appropriate sense (e.g. audibly, visually, or tactilely).
  • The present invention is illustrated herein by example, and various modifications may be made by a person of ordinary skill in the art. For example, while the present invention is described above relative to detecting occlusion in the aspiration circuit of a microsurgical system, it is also applicable to detecting occlusion in the infusion circuit of a microsurgical system.
  • It is believed that the operation and construction of the present invention will be apparent from the foregoing description. While the apparatus and methods shown or described above have been characterized as being preferred, various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined in the following claims.

Claims (26)

1. Apparatus for controlling aspiration in a microsurgical system, comprising:
a pressurized gas source;
a vacuum generator fluidly coupled to said pressurized gas source;
an aspiration chamber fluidly coupled to said pressurized gas source and said vacuum generator;
a fluid level sensor operatively coupled to said aspiration chamber;
a pump fluidly coupled to said aspiration chamber;
a proportional controller; and
a computer electrically coupled to said fluid level sensor, said pump, and said proportional controller;
whereby upon selection of a desired suction flow rate for said aspiration chamber via said proportional controller, said fluid level sensor determines an actual fluid level in said aspiration chamber and provides a signal corresponding to said determined fluid level to said computer, and said computer calculates a suction flow rate in response to said determined fluid level and monitors a change in said suction flow rate to detect an occlusion.
2. The apparatus of claim 1 wherein said computer adjusts a surgical parameter of said apparatus in response to said occlusion.
3. The apparatus of claim 2 wherein said surgical parameter is selected from the group consisting of ultrasound energy, desired suction flow rate, desired suction pressure, infusion pressure, cut rate, and port open duty cycle.
4. The apparatus of claim 1 further comprising a surgical device for aspirating tissue fluidly coupled to said aspiration chamber, and wherein said computer adjusts a surgical parameter of said device in response to said occlusion.
5. The apparatus of claim 1 wherein said vacuum generator is a vacuum chip.
6. The apparatus of claim 1 wherein said vacuum generator is a venturi chip.
7. The apparatus of claim 1 wherein said pump is a peristaltic pump.
8. The apparatus of claim 1 wherein said microsurgical system is an ophthalmic microsurgical system.
9. A method of controlling aspiration in a microsurgical system, comprising the steps of:
creating a desired suction flow rate in an aspiration chamber using a pressurized gas source, a vacuum generator, and a pump;
aspirating fluid from a surgical device into said aspiration chamber;
determining an actual level of said fluid in said aspiration chamber;
calculating a suction flow rate in response to said actual level of fluid; and
monitoring a change in said suction flow rate to detect an occlusion.
10. The method of claim 9 further comprising the step of adjusting a surgical parameter of said apparatus in response to said monitoring step.
11. The method of claim 10 wherein said surgical parameter is selected from the group consisting of ultrasound energy, desired suction flow rate, desired suction pressure, infusion pressure, cut rate, and port open duty cycle.
12. The method of claim 9 further comprising the step of adjusting a surgical parameter of said device in response to said monitoring step.
13. Apparatus for controlling aspiration in a microsurgical system, comprising:
a pressurized gas source;
a vacuum generator fluidly coupled to said pressurized gas source;
an aspiration chamber fluidly coupled to said pressurized gas source and said vacuum generator;
a fluid level sensor operatively coupled to said aspiration chamber;
a pump fluidly coupled to said aspiration chamber;
a proportional controller; and
a computer electrically coupled to said fluid level sensor, said pump, and said proportional controller;
whereby upon selection of a desired suction flow rate for said aspiration chamber via said proportional controller, said fluid level sensor determines an actual fluid level in said aspiration chamber and provides a signal corresponding to said determined fluid level to said computer, and said computer:
calculates a suction flow rate in response to said determined fluid level;
calculates a suction impedance in response to said suction flow rate; and
monitors a change in said suction impedance to detect an occlusion.
14. The apparatus of claim 13 wherein said computer adjusts a surgical parameter of said apparatus in response to said occlusion.
15. The apparatus of claim 14 wherein said surgical parameter is selected from the group consisting of ultrasound energy, desired suction flow rate, desired suction pressure, infusion pressure, cut rate, and port open duty cycle.
16. The apparatus of claim 13 further comprising a surgical device for aspirating tissue fluidly coupled to said aspiration chamber, and wherein said computer adjusts a surgical parameter of said device in response to said occlusion.
17. The apparatus of claim 13 wherein said vacuum generator is a vacuum chip.
18. The apparatus of claim 13 wherein said vacuum generator is a venturi chip.
19. The apparatus of claim 13 wherein said pump is a peristaltic pump.
20. The apparatus of claim 13 wherein said microsurgical system is an ophthalmic microsurgical system.
21. The apparatus of claim 16 wherein said computer communicates a tissue property to a surgeon in response to said suction impedance.
22. A method of controlling aspiration in a microsurgical system, comprising the steps of:
creating a desired suction flow rate in an aspiration chamber using a pressurized gas source, a vacuum generator, and a pump;
aspirating fluid from a surgical device into said aspiration chamber;
determining an actual level of said fluid in said aspiration chamber;
calculating a suction flow rate in response to said actual level of fluid;
calculating a suction impedance in response to said suction flow rate; and
monitoring a change in said suction impedance to detect an occlusion.
23. The method of claim 22 further comprising the step of adjusting a surgical parameter of said apparatus in response to said monitoring step.
24. The method of claim 23 wherein said surgical parameter is selected from the group consisting of ultrasound energy, desired suction flow rate, desired suction pressure, infusion pressure, cut rate, and port open duty cycle.
25. The method of claim 22 further comprising the step of adjusting a surgical parameter of said device in response to said monitoring step.
26. The method of claim 22 further comprising the step of communicating a fluid property to a surgeon in response to said suction impedance.
US11/158,259 2005-06-21 2005-06-21 Aspiration control via flow or impedance Abandoned US20070005030A1 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
US11/158,259 US20070005030A1 (en) 2005-06-21 2005-06-21 Aspiration control via flow or impedance
US11/158,238 US7524299B2 (en) 2005-06-21 2005-06-21 Aspiration control
EP06720911A EP1893250B1 (en) 2005-06-21 2006-02-21 Aspiration control via flow or impedance
PCT/US2006/005956 WO2007001502A2 (en) 2005-06-21 2006-02-21 Aspiration control via flow or impedance
AT06720911T ATE471172T1 (en) 2005-06-21 2006-02-21 ASPIRATION CONTROL VIA FLOW OR IMPEDANCE
ES06720911T ES2344921T3 (en) 2005-06-21 2006-02-21 ASPIRATION CONTROL BY FLOW OR IMPEDANCE.
SI200630583T SI1893251T1 (en) 2005-06-21 2006-02-21 Aspiration control
CA2608633A CA2608633C (en) 2005-06-21 2006-02-21 Aspiration control
DE602006014967T DE602006014967D1 (en) 2005-06-21 2006-02-21 ASPIRATION CONTROL VIA RIVER OR IMPEDANCE
EP06720912A EP1893251B1 (en) 2005-06-21 2006-02-21 Aspiration control
PL06720912T PL1893251T3 (en) 2005-06-21 2006-02-21 Aspiration control
JP2008518129A JP5080460B2 (en) 2005-06-21 2006-02-21 Suction control by flow monitoring
CA2608591A CA2608591C (en) 2005-06-21 2006-02-21 Aspiration control via flow or impedance
PCT/US2006/005957 WO2007001503A2 (en) 2005-06-21 2006-02-21 Aspiration control
DE602006011613T DE602006011613D1 (en) 2005-06-21 2006-02-21 Exhaust control
ES06720912T ES2338147T3 (en) 2005-06-21 2006-02-21 SUCTION CONTROL.
AU2006262933A AU2006262933B2 (en) 2005-06-21 2006-02-21 Aspiration control
PT06720912T PT1893251E (en) 2005-06-21 2006-02-21 Aspiration control
JP2008518130A JP5080461B2 (en) 2005-06-21 2006-02-21 Suction control
AT06720912T ATE454175T1 (en) 2005-06-21 2006-02-21 EXTRACTION CONTROL
AU2006262932A AU2006262932B2 (en) 2005-06-21 2006-02-21 Aspiration control via flow or impedance
DK06720912.2T DK1893251T3 (en) 2005-06-21 2006-02-21 Aspiration control
ARP060101105A AR056947A1 (en) 2005-06-21 2006-03-21 ASPIRATION CONTROL
ARP060101104A AR056946A1 (en) 2005-06-21 2006-03-21 ASPIRATION CONTROL BY FLOW OR IMPEDANCE
US11/491,630 US7594901B2 (en) 2005-06-21 2006-07-24 Surgical cassette with multi area fluid chamber
US12/545,392 US8246580B2 (en) 2005-06-21 2009-08-21 Aspiration control via flow or impedance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/158,259 US20070005030A1 (en) 2005-06-21 2005-06-21 Aspiration control via flow or impedance
US11/158,238 US7524299B2 (en) 2005-06-21 2005-06-21 Aspiration control

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/545,392 Division US8246580B2 (en) 2005-06-21 2009-08-21 Aspiration control via flow or impedance

Publications (1)

Publication Number Publication Date
US20070005030A1 true US20070005030A1 (en) 2007-01-04

Family

ID=38282442

Family Applications (3)

Application Number Title Priority Date Filing Date
US11/158,238 Active 2026-12-18 US7524299B2 (en) 2005-06-21 2005-06-21 Aspiration control
US11/158,259 Abandoned US20070005030A1 (en) 2005-06-21 2005-06-21 Aspiration control via flow or impedance
US12/545,392 Active 2025-12-08 US8246580B2 (en) 2005-06-21 2009-08-21 Aspiration control via flow or impedance

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11/158,238 Active 2026-12-18 US7524299B2 (en) 2005-06-21 2005-06-21 Aspiration control

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/545,392 Active 2025-12-08 US8246580B2 (en) 2005-06-21 2009-08-21 Aspiration control via flow or impedance

Country Status (14)

Country Link
US (3) US7524299B2 (en)
EP (2) EP1893250B1 (en)
JP (2) JP5080460B2 (en)
AR (2) AR056947A1 (en)
AT (1) ATE454175T1 (en)
AU (2) AU2006262933B2 (en)
CA (2) CA2608633C (en)
DE (1) DE602006011613D1 (en)
DK (1) DK1893251T3 (en)
ES (1) ES2338147T3 (en)
PL (1) PL1893251T3 (en)
PT (1) PT1893251E (en)
SI (1) SI1893251T1 (en)
WO (2) WO2007001503A2 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070107490A1 (en) * 2005-11-17 2007-05-17 Alcon, Inc. Surgical cassette
US20070172368A1 (en) * 2006-01-24 2007-07-26 Alcon, Inc. Surgical cassette
US20070207041A1 (en) * 2006-03-01 2007-09-06 Alcon, Inc. Method of operating a peristaltic pump
US20070219494A1 (en) * 2006-03-20 2007-09-20 Gao Shawn X Surgical cassette with bubble separating structure
US20070232990A1 (en) * 2006-03-29 2007-10-04 Alcon, Inc. Surgical system having a cassette with an acoustic coupling
US20070232991A1 (en) * 2006-03-29 2007-10-04 Alcon, Inc. Surgical system having a non-invasive flow sensor
US20070244427A1 (en) * 2006-03-29 2007-10-18 Nader Nazarifar Non-invasive flow measurement
US20080082077A1 (en) * 2006-09-29 2008-04-03 David Lloyd Williams System and method for flow rate control
US20080125697A1 (en) * 2006-09-14 2008-05-29 Alcon, Inc. Method of controlling an irrigation/aspiration system
US20080147023A1 (en) * 2006-12-18 2008-06-19 Mark Alan Hopkins System and method for controlling fluid flow in an aspiration chamber
US20090030372A1 (en) * 2007-07-25 2009-01-29 Filip Finodeyev Liquid/gas separator for surgical cassette
US20100156646A1 (en) * 2008-12-19 2010-06-24 Cull Laurence J System to identify viscosity of aspirated material during ophthalmic surgery
US20170034360A1 (en) * 2009-10-07 2017-02-02 Twilio, Inc. System and method for running a multi-module telephony application

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896833B1 (en) * 2006-01-30 2008-04-04 Coval Soc Par Actions Simplifi DEVICE FOR CONTROLLING A COMPRESSED GAS CONSUMER CIRCUIT AND VACUUM GENERATOR USING THE SAME
US7967777B2 (en) * 2006-11-09 2011-06-28 Abbott Medical Optics Inc. Eye treatment system with multiple pumps
CA2677343C (en) 2007-02-05 2016-06-21 Boston Scientific Limited Thrombectomy apparatus and method
US9510854B2 (en) 2008-10-13 2016-12-06 Boston Scientific Scimed, Inc. Thrombectomy catheter with control box having pressure/vacuum valve for synchronous aspiration and fluid irrigation
US8469050B2 (en) * 2008-11-07 2013-06-25 Abbott Medical Optics Inc. Capacitive fluid level sensing
US8439874B2 (en) * 2008-11-21 2013-05-14 Bausch & Lomb Incorporated Apparatus and method for controlling a vacuum source to establish fluid flow
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
EP2627277B1 (en) 2010-10-12 2019-11-20 Smith & Nephew, Inc. Medical device
IN2014CN04341A (en) 2011-12-08 2015-09-04 Alcon Res Ltd
US9132229B2 (en) * 2012-09-13 2015-09-15 Alcon Research, Ltd. System and method of priming a surgical cassette
JP2016517318A (en) 2013-03-14 2016-06-16 スミス アンド ネフュー インコーポレーテッド System and method for administering decompression therapy
US9737649B2 (en) 2013-03-14 2017-08-22 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
US9549850B2 (en) 2013-04-26 2017-01-24 Novartis Ag Partial venting system for occlusion surge mitigation
EP3033119B1 (en) 2013-08-13 2023-10-11 Smith & Nephew, Inc. Systems for applying reduced pressure therapy
US10137034B2 (en) 2013-11-26 2018-11-27 Novartis Ag Pressure-sensing vitrectomy surgical systems and methods
US10022268B2 (en) 2013-12-17 2018-07-17 Medical Instrument Development Laboratories, Inc. Diaphragm-position-controlled, multi-mode ocular fluid management system and method
US9757273B2 (en) 2013-12-20 2017-09-12 Novartis Ag Tissue-sensing vitrectomy surgical systems and methods
US9248221B2 (en) 2014-04-08 2016-02-02 Incuvate, Llc Aspiration monitoring system and method
US9433427B2 (en) 2014-04-08 2016-09-06 Incuvate, Llc Systems and methods for management of thrombosis
US9883877B2 (en) 2014-05-19 2018-02-06 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
EP3174569B1 (en) 2014-07-31 2020-01-15 Smith & Nephew, Inc Systems and methods for applying reduced pressure therapy
EP3017833B1 (en) * 2014-11-10 2018-05-02 VacSax Limited Suction control apparatus for use in laparoscopy
US10556045B2 (en) 2014-12-30 2020-02-11 Smith & Nephew, Inc. Synchronous pressure sampling and supply of negative pressure in negative pressure wound therapy
WO2016109048A1 (en) 2014-12-30 2016-07-07 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
US10463780B2 (en) * 2015-01-29 2019-11-05 Johnson & Johnson Surgical Vision, Inc. Fluid depletion warning system for phacoemulsification surgical applications
US10702292B2 (en) 2015-08-28 2020-07-07 Incuvate, Llc Aspiration monitoring system and method
US10561440B2 (en) 2015-09-03 2020-02-18 Vesatek, Llc Systems and methods for manipulating medical devices
US20170100142A1 (en) 2015-10-09 2017-04-13 Incuvate, Llc Systems and methods for management of thrombosis
US10226263B2 (en) 2015-12-23 2019-03-12 Incuvate, Llc Aspiration monitoring system and method
JP6719226B2 (en) * 2016-02-17 2020-07-08 泉工医科工業株式会社 Aspirator
US10492805B2 (en) 2016-04-06 2019-12-03 Walk Vascular, Llc Systems and methods for thrombolysis and delivery of an agent
US11051978B2 (en) 2016-05-10 2021-07-06 Alcon Inc. Automated aspiration throttling in vitreoretinal surgery
EP4059530A1 (en) 2016-05-13 2022-09-21 Smith & Nephew, Inc. Automatic wound coupling detection in negative pressure wound therapy systems
AU2017265457C1 (en) 2016-05-17 2022-09-15 Alcon Inc. Automated viscous fluid control in vitreoretinal surgery
US10702415B2 (en) 2016-08-18 2020-07-07 Alcon Inc. Surgical apparatus including aspiration device sensors
WO2018073727A1 (en) 2016-10-19 2018-04-26 Novartis Ag Apparatus for controlling vacuum during ocular surgery
US10184496B2 (en) * 2016-12-06 2019-01-22 Airgas, Inc. Automatic pressure and vacuum clearing skid method
US10478211B2 (en) * 2017-07-07 2019-11-19 Ethicon Llc Features to promote removal of debris from within ultrasonic surgical instrument
EP3691707B1 (en) 2017-10-04 2021-11-17 Johnson & Johnson Surgical Vision, Inc. A system to augment irrigation pressure and to maintain iop during post occlusion surge
US11071816B2 (en) 2017-10-04 2021-07-27 Johnson & Johnson Surgical Vision, Inc. System, apparatus and method for monitoring anterior chamber intraoperative intraocular pressure
EP3691585B1 (en) 2017-10-04 2023-09-27 Johnson & Johnson Surgical Vision, Inc. Systems for measuring fluid flow in a venturi based system
US11116878B2 (en) 2017-11-16 2021-09-14 Alcon Inc. Fluidics aspiration system
US11678905B2 (en) 2018-07-19 2023-06-20 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
US11934209B2 (en) 2020-09-14 2024-03-19 Alcon Inc. Methods and systems for providing control stability in a vacuum generation system using an override proportional-integral-derivative (PID) controller
JP2023543161A (en) * 2020-09-14 2023-10-13 アルコン インコーポレイティド Method and system for providing control stability to a vacuum generation system using a cascaded proportional-integral-derivative (PID) controller

Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670754A (en) * 1970-09-29 1972-06-20 Peter A Freeman Vacuum controlled fluidic regulator
US4041947A (en) * 1974-01-28 1977-08-16 Cavitron Corporation Flow control system
US4210029A (en) * 1979-05-04 1980-07-01 Lad Research Industries, Inc. Differential fiber optic differential pressure sensor
US4548205A (en) * 1982-10-27 1985-10-22 Armeniades C D Ophthalmic instrument for measuring intraocular fluid pressure
US4722350A (en) * 1984-09-21 1988-02-02 Armeniades C D Ophthalmic instrument for measuring intraocular fluid pressure
US4770187A (en) * 1987-06-29 1988-09-13 Md Engineering Surgical aspirator and monitor
US4823552A (en) * 1987-04-29 1989-04-25 Vickers, Incorporated Failsafe electrohydraulic control system for variable displacement pump
US4841984A (en) * 1985-09-16 1989-06-27 Armoor Ophthalmics, Inc. Fluid-carrying components of apparatus for automatic control of intraocular pressure
US4935005A (en) * 1985-06-05 1990-06-19 Nestle, S.A. Opthalmic fluid flow control system
US5098387A (en) * 1989-10-07 1992-03-24 Peter P. Wiest Device for irrigation of and aspiration from body cavities
US5141493A (en) * 1990-01-26 1992-08-25 Sarcos Group Peritoneal dialysis system
US5242404A (en) * 1992-02-12 1993-09-07 American Cyanamid Company Aspiration control system
US5322504A (en) * 1992-05-07 1994-06-21 United States Surgical Corporation Method and apparatus for tissue excision and removal by fluid jet
US5380280A (en) * 1993-11-12 1995-01-10 Peterson; Erik W. Aspiration system having pressure-controlled and flow-controlled modes
US5399166A (en) * 1992-11-23 1995-03-21 Laing; David H. Portable infusion device
US5403276A (en) * 1993-02-16 1995-04-04 Danek Medical, Inc. Apparatus for minimally invasive tissue removal
US5656027A (en) * 1995-06-06 1997-08-12 Cobe Laboratories, Inc. Surgical fluid suction accumulator and volume measurement device
US5674194A (en) * 1995-10-25 1997-10-07 Alcon Laboratories Inc. Process control system
US5676650A (en) * 1994-12-20 1997-10-14 Grieshaber & Co. Ag Schaffhausen Ophthalmologic aspiration and irrigation system, and method of operating same
US5697898A (en) * 1996-05-31 1997-12-16 Surgical Design Corporation Automated free flow mechanism for use in phacoemulsification, irrigation and aspiration of the eye
US5733256A (en) * 1996-09-26 1998-03-31 Micro Medical Devices Integrated phacoemulsification system
US5747824A (en) * 1995-12-01 1998-05-05 Alcon Laboratories, Inc. Apparatus and method for sensing fluid level
US6251113B1 (en) * 1996-08-29 2001-06-26 Bausch & Lomb Surgical, Inc. Ophthalmic microsurgical system employing surgical module employing flash EEPROM and reprogrammable modules
US20020019607A1 (en) * 1998-05-21 2002-02-14 Hai Bui Constant ocular pressure active infusion system
US6413022B1 (en) * 2000-09-18 2002-07-02 The Boeing Company Vacuum clamp device
US6743636B2 (en) * 2001-05-24 2004-06-01 Industrial Technology Research Institute Microfluid driving device
US6865764B2 (en) * 2001-11-08 2005-03-15 Nanya Technology Corporation Fixture for assembling a post-CMP cleaning brush
US20060224143A1 (en) * 2005-03-21 2006-10-05 Claus Michael J Application of vacuum as a method and mechanism for controlling eye chamber stability

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5020535A (en) * 1985-09-26 1991-06-04 Alcon Laboratories, Inc. Handpiece drive apparatus for powered surgical scissors
EP0232458A3 (en) * 1985-09-26 1988-12-14 Alcon Instrumentation, Inc. Multifunctional apparatus for driving powered surgical instruments
US4950016A (en) * 1989-04-24 1990-08-21 Teknocraft, Inc. Integrated pneumatic valve/sensor assembly for vacuum supply apparatus
US5417246A (en) * 1989-10-27 1995-05-23 American Cyanamid Company Pneumatic controls for ophthalmic surgical system
WO1993017729A1 (en) 1992-03-03 1993-09-16 Alcon Surgical, Inc. System and apparatus for controlling fluid flow from a surgical handpiece
AU3665193A (en) * 1992-03-20 1993-10-21 Alcon Surgical, Inc. Fluid flow and pressure control system
US5591127A (en) * 1994-01-28 1997-01-07 Barwick, Jr.; Billie J. Phacoemulsification method and apparatus
US5865764A (en) 1996-12-30 1999-02-02 Armoor Opthalmics, Inc. Device and method for noninvasive measurement of internal pressure within body cavities
US6224345B1 (en) * 1999-03-22 2001-05-01 Bijur Lubrication Corporation pressure/vacuum generator
JP4132897B2 (en) * 2002-03-19 2008-08-13 株式会社日本ピスコ Vacuum generator

Patent Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670754A (en) * 1970-09-29 1972-06-20 Peter A Freeman Vacuum controlled fluidic regulator
US4041947A (en) * 1974-01-28 1977-08-16 Cavitron Corporation Flow control system
US4210029A (en) * 1979-05-04 1980-07-01 Lad Research Industries, Inc. Differential fiber optic differential pressure sensor
US4548205A (en) * 1982-10-27 1985-10-22 Armeniades C D Ophthalmic instrument for measuring intraocular fluid pressure
US4722350A (en) * 1984-09-21 1988-02-02 Armeniades C D Ophthalmic instrument for measuring intraocular fluid pressure
US4935005A (en) * 1985-06-05 1990-06-19 Nestle, S.A. Opthalmic fluid flow control system
US4841984A (en) * 1985-09-16 1989-06-27 Armoor Ophthalmics, Inc. Fluid-carrying components of apparatus for automatic control of intraocular pressure
US4823552A (en) * 1987-04-29 1989-04-25 Vickers, Incorporated Failsafe electrohydraulic control system for variable displacement pump
US4770187A (en) * 1987-06-29 1988-09-13 Md Engineering Surgical aspirator and monitor
US5098387A (en) * 1989-10-07 1992-03-24 Peter P. Wiest Device for irrigation of and aspiration from body cavities
US5141493A (en) * 1990-01-26 1992-08-25 Sarcos Group Peritoneal dialysis system
US5242404A (en) * 1992-02-12 1993-09-07 American Cyanamid Company Aspiration control system
US5322504A (en) * 1992-05-07 1994-06-21 United States Surgical Corporation Method and apparatus for tissue excision and removal by fluid jet
US5399166A (en) * 1992-11-23 1995-03-21 Laing; David H. Portable infusion device
US5403276A (en) * 1993-02-16 1995-04-04 Danek Medical, Inc. Apparatus for minimally invasive tissue removal
US5380280A (en) * 1993-11-12 1995-01-10 Peterson; Erik W. Aspiration system having pressure-controlled and flow-controlled modes
US5676650A (en) * 1994-12-20 1997-10-14 Grieshaber & Co. Ag Schaffhausen Ophthalmologic aspiration and irrigation system, and method of operating same
US5656027A (en) * 1995-06-06 1997-08-12 Cobe Laboratories, Inc. Surgical fluid suction accumulator and volume measurement device
US5674194A (en) * 1995-10-25 1997-10-07 Alcon Laboratories Inc. Process control system
US5747824A (en) * 1995-12-01 1998-05-05 Alcon Laboratories, Inc. Apparatus and method for sensing fluid level
US5697898A (en) * 1996-05-31 1997-12-16 Surgical Design Corporation Automated free flow mechanism for use in phacoemulsification, irrigation and aspiration of the eye
US6251113B1 (en) * 1996-08-29 2001-06-26 Bausch & Lomb Surgical, Inc. Ophthalmic microsurgical system employing surgical module employing flash EEPROM and reprogrammable modules
US5733256A (en) * 1996-09-26 1998-03-31 Micro Medical Devices Integrated phacoemulsification system
US20020019607A1 (en) * 1998-05-21 2002-02-14 Hai Bui Constant ocular pressure active infusion system
US6413022B1 (en) * 2000-09-18 2002-07-02 The Boeing Company Vacuum clamp device
US6743636B2 (en) * 2001-05-24 2004-06-01 Industrial Technology Research Institute Microfluid driving device
US6865764B2 (en) * 2001-11-08 2005-03-15 Nanya Technology Corporation Fixture for assembling a post-CMP cleaning brush
US20060224143A1 (en) * 2005-03-21 2006-10-05 Claus Michael J Application of vacuum as a method and mechanism for controlling eye chamber stability

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8545198B2 (en) 2005-11-17 2013-10-01 Novartis Ag Surgical cassette
US20070107490A1 (en) * 2005-11-17 2007-05-17 Alcon, Inc. Surgical cassette
US20110232358A1 (en) * 2005-11-17 2011-09-29 Artsyukhovich Alexander N Surgical Cassette
US8011905B2 (en) 2005-11-17 2011-09-06 Novartis Ag Surgical cassette
US20070172368A1 (en) * 2006-01-24 2007-07-26 Alcon, Inc. Surgical cassette
US7775780B2 (en) 2006-01-24 2010-08-17 Alcon, Inc. Surgical cassette
US20070207041A1 (en) * 2006-03-01 2007-09-06 Alcon, Inc. Method of operating a peristaltic pump
US8079836B2 (en) 2006-03-01 2011-12-20 Novartis Ag Method of operating a peristaltic pump
US7604615B2 (en) * 2006-03-20 2009-10-20 Alcon, Inc. Surgical cassette with bubble separating structure
US20070219494A1 (en) * 2006-03-20 2007-09-20 Gao Shawn X Surgical cassette with bubble separating structure
US8251944B2 (en) 2006-03-29 2012-08-28 Novartis Ag Surgical system having a cassette with an acoustic coupling
US20070244427A1 (en) * 2006-03-29 2007-10-18 Nader Nazarifar Non-invasive flow measurement
US20070232990A1 (en) * 2006-03-29 2007-10-04 Alcon, Inc. Surgical system having a cassette with an acoustic coupling
US8343100B2 (en) 2006-03-29 2013-01-01 Novartis Ag Surgical system having a non-invasive flow sensor
US8006570B2 (en) 2006-03-29 2011-08-30 Alcon, Inc. Non-invasive flow measurement
US20070232991A1 (en) * 2006-03-29 2007-10-04 Alcon, Inc. Surgical system having a non-invasive flow sensor
US20080125697A1 (en) * 2006-09-14 2008-05-29 Alcon, Inc. Method of controlling an irrigation/aspiration system
US8465467B2 (en) * 2006-09-14 2013-06-18 Novartis Ag Method of controlling an irrigation/aspiration system
US20080082077A1 (en) * 2006-09-29 2008-04-03 David Lloyd Williams System and method for flow rate control
US20080147023A1 (en) * 2006-12-18 2008-06-19 Mark Alan Hopkins System and method for controlling fluid flow in an aspiration chamber
US20090030372A1 (en) * 2007-07-25 2009-01-29 Filip Finodeyev Liquid/gas separator for surgical cassette
US20100156646A1 (en) * 2008-12-19 2010-06-24 Cull Laurence J System to identify viscosity of aspirated material during ophthalmic surgery
US8854221B2 (en) * 2008-12-19 2014-10-07 Bausch & Lomb Incorporated System to identify viscosity of aspirated material during ophthalmic surgery
US20170034360A1 (en) * 2009-10-07 2017-02-02 Twilio, Inc. System and method for running a multi-module telephony application

Also Published As

Publication number Publication date
EP1893250A2 (en) 2008-03-05
WO2007001502A3 (en) 2007-09-27
ATE454175T1 (en) 2010-01-15
ES2338147T3 (en) 2010-05-04
JP2008543488A (en) 2008-12-04
US7524299B2 (en) 2009-04-28
JP2008543487A (en) 2008-12-04
DK1893251T3 (en) 2010-04-26
AU2006262933B2 (en) 2012-03-22
US20100030168A1 (en) 2010-02-04
EP1893251A4 (en) 2009-02-11
EP1893251A2 (en) 2008-03-05
CA2608591A1 (en) 2007-01-04
DE602006011613D1 (en) 2010-02-25
JP5080460B2 (en) 2012-11-21
SI1893251T1 (en) 2010-04-30
CA2608633A1 (en) 2007-01-04
AU2006262932A1 (en) 2007-01-04
AR056947A1 (en) 2007-11-07
EP1893250A4 (en) 2009-04-29
AU2006262932B2 (en) 2012-03-15
US20070005029A1 (en) 2007-01-04
WO2007001503A3 (en) 2007-10-25
CA2608633C (en) 2012-09-04
JP5080461B2 (en) 2012-11-21
WO2007001502A2 (en) 2007-01-04
US8246580B2 (en) 2012-08-21
AU2006262933A1 (en) 2007-01-04
PT1893251E (en) 2010-03-29
AR056946A1 (en) 2007-11-07
EP1893251B1 (en) 2010-01-06
CA2608591C (en) 2012-08-07
WO2007001503A2 (en) 2007-01-04
PL1893251T3 (en) 2010-06-30
EP1893250B1 (en) 2010-06-16

Similar Documents

Publication Publication Date Title
US8246580B2 (en) Aspiration control via flow or impedance
CA2641753C (en) Surgical cassette with multi area fluid chamber
EP2065020A1 (en) An irrigation/aspiration system
US20080125695A1 (en) Reflux control in microsurgical system
US20070135760A1 (en) Occlusion clearance in microsurgical system
US20070000301A1 (en) Reflux control in microsurgical system
ES2344921T3 (en) ASPIRATION CONTROL BY FLOW OR IMPEDANCE.

Legal Events

Date Code Title Description
AS Assignment

Owner name: ALCON, INC., SWITZERLAND

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HOPKINS, MARK A.;HUCULAK, JOHN C.;TODD, KIRK W.;AND OTHERS;REEL/FRAME:017362/0517;SIGNING DATES FROM 20050714 TO 20050725

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION