US20060247571A1 - Dosage form cap for an applicator - Google Patents
Dosage form cap for an applicator Download PDFInfo
- Publication number
- US20060247571A1 US20060247571A1 US11/116,643 US11664305A US2006247571A1 US 20060247571 A1 US20060247571 A1 US 20060247571A1 US 11664305 A US11664305 A US 11664305A US 2006247571 A1 US2006247571 A1 US 2006247571A1
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- United States
- Prior art keywords
- cover
- assembly
- dosage form
- cap
- cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/26—Means for inserting tampons, i.e. applicators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/904—Tampons
Abstract
Description
- Delivery devices and methods of manufacturing delivery devices are used for the application of various therapeutic treatments or other non-medicinal preparations into the vaginal or other cavity.
- Many disease states and physiological conditions may occur in a woman, including symptoms associated with premenstrual syndrome, menstruation, and menopause. These symptoms may include dysmenorrhea (menstrual cramping), irritability, water retention, moodiness, depression, anxiety, skin changes, headaches, breast tenderness, tension, weight gain, cravings, fatigue, hot flashes, itching and other associated sensory maladies.
- Many of these symptoms are due to changes in hormonal levels throughout the menstrual cycle. One example that affects a large number of post-pubescent women is dysmenorrhea, which is the occurrence of painful uterine cramps during menstruation. Menstrual cramping is associated with increased levels of prostaglandin F2α, prostaglandin E2, and, in some cases, leukotrienes in the endometrium and menstrual fluid. These eicosinoids lead to restricted blood flow to the uterus and increased uterine contractions, causing pain.
- Various analgesics may be effective in limiting the pain from dysmenorrhea; however, some orally-delivered analgesics can cause nausea and vomiting or other untoward side effects. As a result, alternative routes of analgesic delivery are of interest.
- Attempts have been made to deliver analgesics in the vicinity of the cervix and the vaginal mucosa using various vaginally-inserted devices and methods. Because many of these symptoms typically occur in conjunction with menstruation, some have tried to combine an analgesic with a tampon by coating the tampon, dipping the tampon, or by combining the analgesic with the tampon materials.
- For example, in a method appropriate for a laboratory setting, a formulation of a fatty compound excipient and an analgesic are heated to a liquid state. Constant mixing of the heated formulation is required to produce a homogeneous formulation. The formulation is then poured onto the tip of a tampon held in a form to contain the liquid. As the formulation cools, the ingredients solidify into a solid waxy substance that has adhered to the absorbent material of the tampon and is thereby securely fastened to the tip of the tampon.
- Several problems are inherent in a process that attempts to introduce a formulation including a therapeutic agent into or onto a tampon by coating, dipping, solidifying, or the like. Processes such as these may work in a laboratory setting but may not be feasible within an automated tampon manufacturing process. Because of dosing requirements, the formulation including a therapeutic agent must be maintained in a solution that is both homogeneous and of the proper purity to ensure consistent concentration of the therapeutic agent. These requirements are difficult to accomplish during production operation of an automated tampon manufacturing process, and are significantly more difficult to maintain when the automated tampon manufacturing process stops. In addition, different styles and sizes of tampons may have different densities and will absorb an applied liquid formulation including a therapeutic agent differently, resulting in variability in the abilities of the tampons to release the therapeutic agent.
- Specifically, the need to provide constant agitation or mixing of the formulation including a therapeutic agent poses challenges as to how to keep a therapeutic agent homogeneously suspended in a solution when the automated tampon manufacturing process stops. The use of inline mixers and recirculation of the heated liquid formulation during machine stops may provide a method to keep the formulation moving and. mixed. However, because a machine could be stopped for several hours, the stability of some formulation mixtures may be compromised by long durations at elevated temperatures, or by mechanical shear forces due to the continuous pumping of the recirculating liquid.
- In addition, environmental conditions, especially during shipping and/or storage, may cause some formulations including a therapeutic agent to melt and absorb into the tampon and/or onto the packaging material prior to use, thus making the therapeutic agent less available for use.
- This disclosure solves these problems by coupling a cover assembly including a dosage form cap to an applicator to form a medicated applicator assembly. The dosage form cap including a therapeutic agent is solid or semi-solid at room temperature, and is sufficiently stable so that it may be manufactured separately in a controlled facility, whereby the therapeutic agent is easily controlled through controls on homogeneity, concentration, and purity.
- The advantages of using a pre-manufactured cover assembly over an in-line process where the medicated ingredients are applied to the tampon coincident with the tampon manufacturing process are numerous. The cover assembly including a dosage form cap may be produced at a pharmaceutical manufacturer whose manufacturing facility meets current regulatory and quality requirements for drugs and/or devices as appropriate. This could ensure that a therapeutic agent with the correct dose and purity is homogeneously dispersed within the dosage form cap. The use of a cover assembly including a dosage form cap simplifies the modifications to an existing tampon manufacturing process. The use of dosage form caps allows multiple types of therapeutic agents to be applied with the tampon. The chemical and physical stabilities of the dosage form cap are not compromised by the assembly process with the tampon. The manufacturing process is less dependent on the physical characteristics of the absorbent structure of the tampon because the dosage form cap is not required to bond with the tampon.
- This disclosure relates to cover assemblies for use with applicator assemblies that may be integral with or associated with feminine care products. The therapeutic agent delivery system including the therapeutic agent and excipients may include any therapeutic agent that will be absorbed into the body through the vaginal or other epithelium, or deposited topically on the vaginal or other epithelium, for the purposes of treating a physiological disease, state, or condition.
- Objects and advantages will become apparent to those skilled in the art in view of the following description and the accompanying drawings.
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FIG. 1 is an exploded perspective view of a medicated applicator assembly of the present invention. -
FIG. 2 is an exploded partially cutaway perspective view of a cover assembly with a barrier seal to be used in conjunction with the medicated applicator assembly ofFIG. 1 . -
FIG. 3 is an exploded perspective view of a medicated applicator assembly including a medicated tampon of the present invention. -
FIG. 4 is an exploded partially cutaway perspective view of a cover assembly with a barrier seal to be used in conjunction with the medicated applicator assembly ofFIG. 3 . -
FIG. 5 is an exploded perspective view of a cover assembly with a barrier to be used in conjunction with the medicated applicator assembly ofFIG. 3 . -
FIG. 6 is a partial perspective view of an engagement mechanism for the cover assembly and the applicator assembly ofFIG. 3 . -
FIG. 7 is a partial perspective view of another aspect of an engagement mechanism for the cover assembly and the applicator assembly ofFIG. 3 . - The embodiments as described herein will be described for exemplary purposes using a tampon as an example of a feminine care product. The embodiments, however, apply equally to other forms of products, including tampon-like devices and vaginally- and anally-inserted devices, and should not be limited to the example described herein. In addition, although the example described includes a tampon with absorbent material, a product without absorbent material, such as a tampon applicator or other similar applicator, is also contemplated within the invention. Also contemplated is the use in conjunction with non-catamenial feminine products such as incontinence products, including female incontinence inserts.
- The term “surface” and its plural generally refer herein to the outer or the topmost boundary of an object.
- The term “dosage form cap” is used herein as a generic term for a unit form of a formulation that includes a therapeutic agent. The dosage form cap includes a discrete and consistent quantity of the therapeutic agent to allow for consistent dosing of one receiving the dosage form cap. The dosage form cap may be any suitable shape dictated by the needs of the application of the dosage form cap. The dosage form cap may have convex, concave, planar, arcuate, or any other suitable surfaces as dictated by the needs of the application of the dosage form cap.
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FIG. 1 illustrates a delivery device in the form of a medicatedapplicator assembly 10, in this case including atampon assembly 40 and adosage form cap 45. Thetampon assembly 40 includes atampon applicator 12 and acatamenial tampon 20. Thetampon applicator 12 includes a first member orouter tube 14 and a second member orinner tube 18, where thetampon applicator 12 is designed to house thecatamenial tampon 20 and provide a comfortable means of inserting thetampon 20 into a woman's vagina. Thedosage form cap 45 is designed to couple to thefirst member 14, as is described in more detail below. In another aspect of the present invention, thetampon assembly 40 or thetampon applicator 12 may be referred to simply as an applicator, particularly if thetampon assembly 40 does not include atampon 20, or if thetampon applicator 12 is not associated with atampon 20 - The
first member 14 may be in the form of a spirally wound, convolutely wound or longitudinally seamed hollow tube which is formed from paper, paperboard, cardboard, plastic, other suitable material, or a combination of such materials. Any plastic in thefirst member 14 is preferably polyethylene, but may be polypropylene or other suitable plastic. Thefirst member 14, also commonly referred to as an outer tube, may be of any suitable dimensions necessary to house a particular size oftampon 20. Thefirst member 14 has an outside orexterior surface 24. - The
first member 14 is sized and configured to house theabsorbent tampon 20, should one be present, and should have a substantially smoothexterior surface 24 which will facilitate insertion of thefirst member 14 into a woman's vagina. When theexterior surface 24 is smooth and/or slippery, thefirst member 14 will easily slide into a woman's vagina without subjecting the internal tissues of the vagina to abrasion. Thefirst member 14 may be coated to give it a high slip characteristic. Wax, polyethylene, a combination of wax and polyethylene, cellophane, and clay are representative coatings that may be applied to thefirst member 14 to facilitate comfortable insertion. Thefirst member 14 itself may be formulated to give it a high slip characteristic, including the addition of additives to the resin from which the first member is made, or by an alteration in physical structure of theexterior surface 24, such as adding pebbling or other bumps, to decrease the amount of surface area in contact with the vaginal or other epithelium. - Referring to
FIG. 1 , thefirst member 14 has aninsertion end 26 and a receivingend 30. Theinsertion end 26 is shown without petals, such that it simply has an opening of a diameter approximately equal to the diameter of thefirst member 14. In other aspects of the present invention, the diameter of the opening at theinsertion end 26 may be larger or smaller than the diameter of thefirst member 14. - In another aspect of the present invention that is not shown, the
insertion end 26 may be configured to have a plurality of pleats or petals that may radially open such that theinsertion end 26 has a diameter approximately equal to the diameter of thefirst member 14. The petals may be either even or odd in number and may be equally spaced apart or non-uniformly arranged. - As stated above, the medicated
applicator assembly 10 includes asecond member 18, also commonly referred to as an inner tube. Thesecond member 18, like thefirst member 14, may be a spirally wound, a convolutely wound or a longitudinally seamed hollow tube constructed from paper, paperboard, cardboard, plastic, other suitable material, or a combination thereof. Thesecond member 18 may be constructed of the same material as thefirst member 14 or it may be made out of a different material. Thesecond member 18 may also be a solid stick or use some other unique shape. It is also possible to form afinger flange 32 on thefree end 31 of thesecond member 18 to provide an enlarged surface onto which the user's forefinger may rest. Thefinger flange 32 thereby functions as a seat for the forefinger and facilitates movement of thesecond member 18 into thefirst member 14. Thefirst member 14 may have afingergrip ring 28 located proximate the receivingend 30. Thefingergrip ring 28 provides an enlarged surface onto which one or more fingers of the user may rest. In use, the user may position one or more fingers on thefingergrip ring 28 and one or more fingers on thefinger flange 32. The user then holds thefingergrip ring 28 and pushes thefinger flange 32 to move thesecond member 18 toward and into thefirst member 14. - A
tampon 20, should one be present, is an absorbent member primarily designed to be worn by a woman during her menstrual period to absorb menses and other body fluids. Thetampon 20 includes atampon body 34 and a withdrawal string (not shown). Thetampon body 34 is normally compressed into the form of a cylinder and may have a blunt, rounded or shaped forward end. Thetampon body 34 has a forward ordistal end 38 that is closer to the cervix when thetampon 20 is in use. Thetampon body 34 also has aproximal end 39 that is closer to the vaginal opening when thetampon 20 is in use. Thetampon 20 commonly has a withdrawal string fastened to thetampon body 34 and extending from theproximal end 39. The withdrawal string serves as a means for withdrawing thetampon 20 from the woman's vagina. Catamenial tampons suitable for use in the present invention include any absorbent material as is known in the art. Thedistal end 38 of thetampon body 34 or thetampon body 34 itself may be formed into specific shapes such as various cup shapes to enhance the contact area with the cervix, anterior fornix, posterior fornix, lateral fornices, vaginal epithelium areas, or conformance to other anatomical areas within the vaginal or other cavity. - A medicated
applicator assembly 10, which may include thetampon 20, includes a therapeutic agent included in adosage form cap 45, which is typically located within acover assembly 50. Thecover assembly 50 includes adosage form cap 45 and acover 80 enclosing thedosage form cap 45. As shown inFIG. 2 , abarrier seal 110 may also be employed to seal thedosage form cap 45 within thecover 80. - Referring to
FIG. 2 , thedosage form cap 45 has acap attachment end 46 and a cap taperedend 47. Thedosage form cap 45 also includes a capouter surface 48 and, if thedosage form cap 45 is concave (shown inFIG. 5 ), a capinner surface 49, where the capinner surface 49 defines and at least partially encloses acap cavity 51. - The
cap attachment end 46 of thedosage form cap 45 includes aportion 54 of a cap engagement mechanism 52 (seeFIG. 1 ) that allows thedosage form cap 45 to be attached to the first member 14 (which includes another portion of the cap engagement mechanism 52) with minimal force. The attachment provided by thecap engagement mechanism 52 is preferably two-way or reversible in use. - The
cap engagement mechanism 52 between thedosage form cap 45 and thefirst member 14 is shown inFIG. 1 as having a snap-on engagement profile. Such a profile is convenient to manufacture and may be assembled with minimal force. Thecap engagement mechanism 52 may be any other suitable mechanism. - In another aspect of the present invention, the
cap engagement mechanism 52 may be a biologically-compatible adhesive or any other material suitable for at least temporarily adhering thedosage form cap 45 to thefirst member 14. In this case, the bio-adhesive may be applied to the capinner surface 49 only adjacent thecap attachment end 46, allowing thedosage form cap 45 to be affixed to thefirst member 14 by the bio-adhesive. - Referring to
FIG. 2 , thecover assembly 50 may also include acover 80 provided to enclose and protect thedosage form cap 45. Thecover 80 is shown as being generally cylindrical, but the shape is not essential to the invention described herein and any suitable shape may be used. In alternate aspects, thecover 80 may be generally triangular or square or have a flattened side to inhibit the medicatedapplicator assembly 10 from rolling on a hard surface such as a countertop. Thecover 80 includes a coveropen end 82, a coveropen end surface 84, and a coverinner surface 86 that defines and at least partially encloses acover cavity 88. Thecover cavity 88 projects inwardly from the coveropen end 82. Thecover 80 may be manufactured from polyethylene, rubber, or other similar materials that will not adversely interact with thedosage form cap 45 if contact is made therewith. - The
cover cavity 88 is sized and shaped such that thedosage form cap 45 fits entirely within thecover cavity 88, preferably with the coverinner surface 86 reflecting the shape of the capouter surface 48 of thedosage form cap 45 such that the capouter surface 48 of thedosage form cap 45 maintains general contact with the coverinner surface 86. Thecover 80 is removable and is necessarily removed prior to use of the medicatedapplicator assembly 10 by a consumer. - The
dosage form cap 45 may be formed directly within thecover cavity 88 by depositing a formulation including a therapeutic agent directly into thecover cavity 88. Alternatively, thedosage form cap 45 may also be pre-manufactured in the same or separate facility and then placed within thecover cavity 88 during manufacture of thecover assembly 50. Further detail concerning the manufacture of a dosage form, in this case adosage form cap 45, is disclosed in co-pending U.S. patent application Ser. No. ______ filed on and titled ______. - In one aspect of the present invention, the
dosage form cap 45 may be produced in any suitable form including, but not limited to, suppositories, gels, films, coatings, and other forms. In an alternate aspect of the present invention, thedosage form cap 45 may be produced in encapsulated form. - In another aspect of the present invention, the
dosage form cap 45 may be designed to melt at approximately body temperature, or to dissolve or otherwise disperse in the presence of a sufficient aqueous or other liquid trigger, or appropriate chemistry, such as a suitable pH. - In an additional aspect of the present invention, the
dosage form cap 45 may be formed in any shape to promote contact with anatomical structures such as the vaginal epithelium, the anterior fornix, the posterior fornix, the cervix, or other structures. - The
dosage form cap 45 may include any therapeutic agent, along with any excipients, compounds, or other ingredients that are desirable to introduce into the vaginal or other cavity to promote the functionality of that therapeutic agent. The excipients may assist the release of the therapeutic agent, or assist in the absorbency of the therapeutic agent into the vaginal or other epithelium. The use of excipients to facilitate the formulation, delivery, stability, and aesthetic properties of a therapeutic agent delivery system is well known to those familiar with the art. Examples of ingredients that may accompany the therapeutic agent in thedosage form cap 45 include excipients, biologically-compatible adhesives, surfactants, and penetration enhancers. An example of a suitable excipient is SUPPOCIRE suppository base, available from Gattefosse Corp. SUPPOCIRE suppository base is a semi-synthetic glyceride. An example of a suitable biologically-compatible adhesive is hydroxypropyl methylcellulose (HPMC), available as METHOCEL* K15M from The Dow Chemical Company. An example of a suitable surfactant ispolysorbate 80, available from Spectrum Chemical Manufacturing Corp. An example of a suitable penetration enhancer is LABRAFIL M 1944 C nonionic amphiphilic excipient, available from Gattefosse Corp. - For the purposes of this invention, any therapeutic agent that will treat the vaginal or other cavity, other mucosal tissue, or will be absorbed into a user's body through the vaginal or other epithelium for the purposes of treating diseases or conditions, promoting the growth of normal vaginal bacterial flora, or promoting vaginal health may be used. Examples of therapeutic agents include but are not limited to vitamins, minerals, hormones, moisturizers, antifungal agents, antibacterial agents, pro-biotics, botanicals, analgesics, prostaglandin inhibitors, prostaglandin synthetase inhibitors, leukotriene receptor antagonists, essential fatty acids, sterols, anti-inflammatory agents, vasodilators, chemotherapeutic agents, and agents to treat infertility.
- Some therapeutic agents for use in this invention are absorbable through the vaginal epithelium and travel to the uterus by a unique portal of veins and arteries that are known to exist between the vagina, the cervix, and the uterus. This anastomosis eliminates first-pass metabolism by the liver, effectively delivering higher concentrations of the therapeutic agent to the uterus than would otherwise be available via oral dosing. Those of skill in the art know the efficacy of various therapeutic agents when introduced at a particular anatomical location. For example, when the therapeutic agent is selected to treat dysmenorrhea, it preferably is selected from the following group: nonsteroidal anti-inflammatory drugs (NSAIDs), prostaglandin inhibitors, COX-2 inhibitors, local anesthetics, calcium channel blockers, potassium channel blockers, β-adrenergic agonists, leukotriene blocking agents, smooth muscle inhibitors, and drugs capable of inhibiting dyskinetic muscle contraction. Alternatively therapeutic agents modify the vaginal or other environment to enhance the wellness of this anatomical region. The benefits may be rather simple, for example increasing comfort by providing moisturization and/or lubricity. These benefits may also be more complex, for example modulating epithelial cell function to address vaginal atrophy. The beneficial therapeutic agents may reduce negative sensations such as stinging, burning, itching, etc, or introduce positive sensations to improve comfort.
- Referring to
FIG. 2 , thecover assembly 50 may also include aremovable insert 90. Theinsert 90 has aninsert surface 92 that is shaped to generally conform to the capinner surface 49 of thedosage form cap 45. Theinsert 90 may be formed from any suitable material that will not adversely interact with thedosage form cap 45. The primary purpose of theinsert 90 is to help maintain the shape of thedosage form cap 45 during shipping and handling. - The
cover assembly 50 may also include aremovable barrier seal 110 to seal thedosage form cap 45 within thecover cavity 88. Thebarrier seal 110 may be disposed at the coveropen end 82 of thecover 80 such that thebarrier seal 110 extends radially beyond thecover cavity 88 to contact the coveropen end surface 84. Thebarrier seal 110 may project into thecover cavity 88 to improve the seal between thebarrier seal 110 and thecover 80. Thebarrier seal 110 is affixed to thecover 80 at the coveropen end surface 84 using any suitable adhesive or affixing means, including the use of hot-melt, water-based, solvent-based, or pressure-sensitive adhesives, mucilage, a thermal seal, ultrasonic bonding, pressure, friction, electrostatics, cling-like poly wraps, or surface energy effects. Thebarrier seal 110 remains affixed during shipping and handling, but may be removed by a manufacturer or a consumer to reveal the contents of thecover 80. Thebarrier seal 110 may be formed from any suitable material, including foil, poly, film, film laminates, nonwovens, nonwoven laminates, protective materials such as TYVEK protective material, and any suitable elastomeric substance including rubber, or by a combination of these materials as long as the material of thebarrier seal 110 will not adversely interact with thedosage form cap 45 or any bio-adhesive that may be present on thedosage form cap 45. - In another aspect of the present invention shown in
FIGS. 3-5 , thecover assembly 50 includes atip 60 in addition to thedosage form cap 45, with thetip 60 positioned within thedosage form cap 45. As shown inFIG. 4 , abarrier seal 110 may also be employed to seal thedosage form cap 45 and thetip 60 within thecover 80. - Referring to
FIGS. 3-5 , thecover assembly 50 includes atip 60 with atip attachment end 62 and a tipsecond end 64. Thetip 60 has a plurality ofpetals 66 at the tipsecond end 64 that may radially open such that thetip 60 has a diameter approximately equal to or greater than the diameter of thefirst member 14. Thepetals 66 may be either even or odd in number and may be equally spaced apart or non-uniformly arranged. Between any twopetals 66 is agap 68 that provides additional flexibility to thepetals 66. In another aspect of the present invention that is not shown, thegaps 68 may be filled by a frangible portion such that the tipsecond end 64 is closed bypetals 66 and frangible portions until force applied by thedosage form 45, thetampon 20, or thesecond member 18 causes the frangible portions to break, allowing thepetals 66 to open. - The
tip 60 also includes a tipouter surface 70 and a tipinner surface 72, where the tipinner surface 72 defines and at least partially encloses atip cavity 74. Thetip 60 is preferably manufactured from material similar to that of thefirst member 14, but any suitable material that will not adversely interact with the dosage form may be used. - Within the
cover assembly 50, thetip 60 is positioned in thecap cavity 51. The tipouter surface 70 generally conforms in shape to the capinner surface 49. Thedosage form cap 45 is affixed to thetip 60 using an adhesive, a bio-adhesive, or by any other suitable means such that thedosage form cap 45 remains affixed to thetip 60 during handling and shipping, but detaches from thetip 60 inside the vaginal or other cavity upon insertion of thedosage form cap 45. - The
attachment end 62 of thetip 60 includes an engagement mechanism 76 (shown inFIG. 5 ) that allows thetip 60 to be attached to thefirst member 14 with minimal force. The attachment provided by theengagement mechanism 76 is preferably one-way or permanent. for the improved structural integrity of thetip 60 with thefirst member 14 in use. In most types of engagement mechanisms suitably applied in such an application, theengagement mechanism 76 typically includes afirst portion 77 and asecond portion 78, where thefirst portion 77 engages with thesecond portion 78 to complete theengagement mechanism 76. Thefirst portion 77 is positioned on one of thetip 60 or thefirst member 14, and thesecond member 78 is positioned on the other of thetip 60 or thefirst member 14. - In an example of a screw-type engagement mechanism 176 illustrated in
FIG. 6 , thetip 60 includes a first portion 177 including helically-positioned projections 179, and thefirst member 14 includes a second portion 178 including helically-positioned projection-receiving spaces 181. Thetip 60 is moved toward and twisted onto thefirst member 14 such that the helically-positioned projections 179 engage or interlock with the projection-receiving spaces 181. In another aspect of this example (not shown), the first portion 177 including helically-positioned projections 179 is positioned on thefirst member 14, and the second portion 178 including helically-positioned projection-receiving spaces 181 is positioned on thetip 60. - In an example of a quarter-turn-type engagement mechanism 276 illustrated in
FIG. 7 , thetip 60 includes a first portion 277 including a helically-positioned projection 279, and thefirst member 14 includes a second portion 278 including a helically-positioned projection-receiving space 281. Thetip 60 is moved toward and twisted onto thefirst member 14 such that the helically-positioned projection 279 engages or interlocks with the projection-receiving space 281. In another aspect of this example (not shown), the first portion 277 including a helically-positioned projection 279 is positioned on thefirst member 14, and the second portion 278 including a helically-positioned projection-receiving space 281 is positioned on thetip 60. - The
engagement mechanism 76 between thetip 60 and thefirst member 14 is shown inFIG. 5 as having a snap-on engagement profile. Such a profile is convenient to manufacture, may be assembled with minimal force, and creates the one-way attachment preferred for the structural integrity of this product. Theengagement mechanism 76 may be any other suitable mechanism, including, but not limited, to a snap ring, conventional screw threads, quarter-turn threads, a mechanical latch, and an escapement-type mechanism. - In the aspect shown in
FIGS. 3-5 , thecover assembly 50 may also include a removable insert (not shown). The insert has an insert surface that is shaped to generally conform to the tipinner surface 72 of thetip 60 with the primary purpose of sealing thegaps 68 to help maintain the shape of thedosage form cap 45 during shipping and handling. The insert may be formed from any suitable material that will not adversely interact with thedosage form cap 45. In another aspect, thebarrier seal 110 may be shaped to conform to the tipinner surface 72. - Returning to
FIG. 1 , thedosage form cap 45 and thetampon assembly 40 are combined to form the medicatedapplicator assembly 10. Acover assembly 50 including adosage form cap 45 is axially aligned with atampon assembly 40. Thecover assembly 50 and thetampon assembly 40 are moved toward each other using minimal force to cause the engagement mechanism of thedosage form cap 45 and thefirst member 14 to engage, resulting in thedosage form cap 45 becoming removably attached to thefirst member 14. The medicatedapplicator assembly 10 may then be packaged and shipped. Alternatively, thetampon assembly 40 and thecover assembly 50 withdosage form cap 45 may be packaged separately and shipped together or separately. These may later be combined by an assembler or a consumer. - Turning to
FIG. 3 , thedosage form cap 45, thetip 60, and thetampon assembly 40 are combined to form the medicatedapplicator assembly 10. Acover assembly 50 including adosage form cap 45 and atip 60 is axially aligned with atampon assembly 40. Thecover assembly 50 and thetampon assembly 40 are moved toward each other using minimal force to cause the engagement mechanism of thetip 60 and thefirst member 14 to engage, resulting in thetip 60 becoming removably attached to thefirst member 14. The medicatedapplicator assembly 10 may then be packaged and shipped. Alternatively, thetampon assembly 40 and thecover assembly 50 with thedosage form cap 45 and thetip 60 may be packaged separately and shipped together or separately. These may later be combined by an assembler or a consumer. - More specifically, the various components of the medicated
applicator assembly 10 may be manufactured and assembled in a variety of ways, but generally focus on three subassemblies: thetampon assembly 40, thecover assembly 50, and thedosage form cap 45. - The
dosage form cap 45 may be produced by the same manufacturer as the manufacturer of thetampon assembly 40. Thedosage form cap 45 may also be produced by a separate manufacturer and provided to the tampon manufacturer in any suitable manner. As an example, a dosage form manufacturer with a facility specifically designed for pharmaceutical manufacturing that meets current regulatory and quality requirements for drugs and/or devices, as appropriate, may produce the dosage form caps 45 under conditions such that homogeneity, concentration, and purity of thedosage form cap 45 are closely controlled, and such that production is in accordance with applicable regulations. Thedosage form cap 45 may then be sealed and shipped to the manufacturer of either thetampon assembly 40 or thecover assembly 50. In this manner, thedosage form cap 45 is produced by a manufacturer with appropriate experience, and the tampon manufacturer may be relieved of establishing a pharmaceutical-production facility. This process is described in more detail in co-pending U.S. patent application Ser. No. ______ filed on ______ and titled ______. - Likewise, the
cover assembly 50 including adosage form cap 45 may be produced by the same manufacturer as the manufacturer of thetampon assembly 40. Thecover assembly 50 including adosage form cap 45 may also be produced by a separate manufacturer and provided to the tampon manufacturer in any suitable manner. As an example, a pharmaceutical manufacturer with a facility specifically designed for pharmaceutical manufacturing that meets current regulatory and quality requirements for drugs and/or devices, as appropriate, may producecover assemblies 50 including dosage form caps 45 under conditions such that homogeneity, concentration, and purity of thedosage form cap 45 are closely controlled, and such that production is in accordance with applicable regulations. Thecover assembly 50 including thedosage form cap 45 may then be sealed and shipped to the tampon manufacturer. The tampon manufacturer may then apply thecover assembly 50 including adosage form cap 45 to atampon assembly 40 under appropriately-controlled conditions. In this manner, thecover assembly 50 with adosage form cap 45 is produced by a manufacturer with appropriate experience, and the tampon manufacturer is relieved of establishing a pharmaceutical-production facility. - In another aspect of the present invention, the
tampon assembly 40 may be produced by a manufacturer different from the manufacturer of thecover assembly 50 and both assemblies (40, 50) may be shipped to the manufacturer of thedosage form cap 45 for manufacture of the medicatedtampon assembly 10. In another aspect of the present invention, the medicatedtampon assembly 10 is produced by a manufacturer different from the manufacturer of thedosage form cap 45, the manufacturer of thetampon assembly 40, and the manufacturer of thecover assembly 50. - In any case, the
dosage form cap 45, thecover assembly 50, and thetampon assembly 40 are each manufactured. Thedosage form cap 45 and coverassembly 50 are combined and sealed if appropriate, and then the cover assembly 50 (with dosage form cap 45) is combined with atampon assembly 40, by either a manufacturer or by a consumer. - In another aspect of the present invention, the
dosage form cap 45 may be combined by a manufacturer with atampon assembly 40 without the use of acover assembly 50. Thedosage form cap 45 is attached to thefirst member 14, and the combination is sealed, packaged, and shipped. - In a different aspect of the present invention, the
tampon assembly 40 and thecover assembly 50 withdosage form cap 45 may be packaged separately. Both may then be provided to a consumer, either separately or in one package or kit. The consumer may also obtain thecover assembly 50 and thetampon assembly 40 from separate manufacturers. In either case, either assembly may include instructions for use of a medicatedapplicator assembly 10. Such instructions may include information regarding when a medicatedapplicator assembly 10 is appropriate to use, standard pharmaceutical information regarding thedosage form cap 45 and therapeutic agent(s) contained therein, and directions regarding the method for properly combining thedosage form cap 45 and thetampon assembly 40. The consumer will be instructed to remove both atampon assembly 40 and acover assembly 50 from their packaging. The consumer will then remove thebarrier seal 110 from thecover assembly 50. The consumer will also remove theinsert 90 if one is present. The consumer will then be instructed to attach thedosage form cap 45 or thetip 60, as appropriate, to thetampon assembly 40 by whatever method is appropriate for the type ofengagement mechanism 76 is present such that thedosage form cap 45 or thetip 60, as appropriate, becomes engaged with thetampon assembly 40. Finally, the consumer will be instructed to remove thecover 80 from the medicatedapplicator assembly 10 and use the medicatedapplicator assembly 10 as one would use a standard tampon. - In a different aspect of the present invention, a consumer may be provided with a
cover assembly 50 including adosage form cap 45, along with atampon assembly 40 that does not include atampon 20. The assembly and use in this case will be similar to that of the complete medicatedapplicator assembly 10, but the consumer will be using thedosage form cap 45 alone without thetampon 20. - In use, and referring to
FIG. 1 , the medicatedapplicator assembly 10 functions because thesecond member 18 is telescopically movable relative to thefirst member 14. As thesecond member 18 is pushed into thefirst member 14, thetampon 20 is forced forward against the first member petals if thefirst member 14 includes petals, or against thepetals 66 if thetip 60 is present. The contact by thetampon 20 causes thepetals 66 to radially open to a diameter that is sufficient to allow thetampon 20 to be expelled from thefirst member 14. As thetampon 20 passes through thepetals 66, thetampon 20 and/or thepetals 66 are forced against thedosage form cap 45, causing it to release from thefirst member 14. With thedosage form cap 45 and thetampon 20 properly positioned in the vaginal or other cavity, thetampon applicator 12 is withdrawn and properly discarded. - Once the
tampon 20 is properly positioned in the vaginal or other cavity, thetampon body 34 absorbs menses and other bodily fluids, and thedosage form cap 45 delivers the therapeutic agent to the vaginal or other epithelium. From there, the therapeutic agent may be transferred to the uterus by normal bodily functions to relieve the uterine condition to be treated. - For use in the situation in which the medicated
applicator assembly 10 does not include atampon 20, thesecond member 18 is pushed into thefirst member 14 and thesecond member 18 is forced forward against the first member petals if thefirst member 14 includes petals, or against thepetals 66 if thetip 60 is present. The contact by thesecond member 18 causes thepetals 66 to radially open to a diameter that is sufficient to allow thesecond member 18 to pass through thepetals 66. Thesecond member 18 and/or thepetals 66 are forced against thedosage form cap 45, causing it to release from thefirst member 14. With thedosage form cap 45 properly positioned in the vaginal or other cavity, thetampon applicator 12 is withdrawn and properly discarded. - Once the
dosage form cap 45 is properly positioned in the vaginal or other cavity, thedosage form cap 45 delivers the therapeutic agent to the vaginal or other epithelium. From there, the therapeutic agent may be transferred to the uterus by normal bodily functions to relieve the uterine condition to be treated. - The invention has been described with reference to various specific and illustrative aspects and techniques. However, it should be understood that many variations and modifications may be made while remaining within the spirit and scope of the invention.
- Accordingly, this invention is intended to embrace all such alternatives, modifications and variations that fall within the spirit and scope of the appended claims.
Claims (30)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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US11/116,643 US7708726B2 (en) | 2005-04-28 | 2005-04-28 | Dosage form cap for an applicator |
EP06749094A EP1890758B1 (en) | 2005-04-28 | 2006-03-30 | Dosage form cap for an applicator |
PCT/US2006/012122 WO2006115699A1 (en) | 2005-04-28 | 2006-03-30 | Dosage form cap for an applicator |
MX2007013448A MX2007013448A (en) | 2005-04-28 | 2006-03-30 | Dosage form cap for an applicator. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US11/116,643 US7708726B2 (en) | 2005-04-28 | 2005-04-28 | Dosage form cap for an applicator |
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US20060247571A1 true US20060247571A1 (en) | 2006-11-02 |
US7708726B2 US7708726B2 (en) | 2010-05-04 |
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US11/116,643 Expired - Fee Related US7708726B2 (en) | 2005-04-28 | 2005-04-28 | Dosage form cap for an applicator |
Country Status (4)
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US (1) | US7708726B2 (en) |
EP (1) | EP1890758B1 (en) |
MX (1) | MX2007013448A (en) |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050215939A1 (en) * | 2002-02-22 | 2005-09-29 | Playtex Products, Inc. | Multiple-component tampon applicator |
US20070128254A1 (en) * | 2005-12-07 | 2007-06-07 | Heuer Daniel J | Methods of attaching a dosage form to a medicated tampon assembly |
US20100036308A1 (en) * | 2008-08-07 | 2010-02-11 | Ottuso Patrick | Wound penetrating hemostatic device impregnated with coagulant, antibiotic and/or anesthetic |
US7666160B2 (en) * | 2006-12-29 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery device |
US20140155810A1 (en) * | 2012-06-25 | 2014-06-05 | Playtex Products, Llc | Package assembly for or with a tampon applicator |
AU2017265175B2 (en) * | 2013-12-16 | 2020-02-06 | Esther GALLANT | Device and method for inserting lubricating capsule |
US20210220184A1 (en) * | 2018-08-03 | 2021-07-22 | Anne's Day Ltd | Absorbent tampon for treatment of menstrual symptoms |
US20210322740A1 (en) * | 2020-04-15 | 2021-10-21 | The Procter & Gamble Company | Methods and applicators for treating vaginal conditions |
US11565096B2 (en) | 2021-01-14 | 2023-01-31 | Herphoric, Inc. | Delivery system for a pharmaceutical, holistic or medicinal component |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7919453B2 (en) * | 2005-03-25 | 2011-04-05 | Kimberly-Clark Worldwide, Inc. | Dosage cap assembly for an applicator |
US7993667B2 (en) | 2005-03-25 | 2011-08-09 | Kimberly-Clark Worldwide, Inc. | Methods of manufacturing a medicated tampon assembly |
US8747346B2 (en) * | 2007-06-01 | 2014-06-10 | Martin Hochberg | Hemostatic agent applicator for survical procedures |
US7963934B2 (en) * | 2007-10-25 | 2011-06-21 | Morrow Jacqueline M | Tampon applicator assembly |
US20130038063A1 (en) * | 2011-08-12 | 2013-02-14 | Jack Joseph Tawil | Apparatus and method for inhibiting the formation of tropical cyclones |
US20150090732A1 (en) * | 2013-10-02 | 2015-04-02 | The Plasticsam Limited | Object storage device and method |
US20230301843A1 (en) * | 2022-03-25 | 2023-09-28 | Monique Rini | Tampon/suppository hybrid |
Citations (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US706778A (en) * | 1901-12-03 | 1902-08-12 | Edmund Morse Pond | Medicated tampon. |
US749220A (en) * | 1904-01-12 | Medicated tampon | ||
US812769A (en) * | 1904-07-19 | 1906-02-13 | Edmund M Pond | Medicated tampon. |
US812770A (en) * | 1904-09-12 | 1906-02-13 | Edmund Morse Pond | Medicated tampon. |
US812768A (en) * | 1903-07-24 | 1906-02-13 | Edmund M Pond | Medicated tampon. |
US1234383A (en) * | 1916-11-17 | 1917-07-24 | Edmund Morse Pond | Medicated tampon. |
US2473368A (en) * | 1944-02-25 | 1949-06-14 | Flintermann Gerhard | Suppository |
US2739593A (en) * | 1954-02-25 | 1956-03-27 | Zonite Products Corp | Medicated vaginal tampons |
US2922423A (en) * | 1956-05-10 | 1960-01-26 | Kimberly Clark Co | Tampon ejector |
US3086527A (en) * | 1959-03-18 | 1963-04-23 | David C Forrest | Medical applicator |
US3515138A (en) * | 1967-07-05 | 1970-06-02 | Josef Hochstrasser | Process and apparatus for treating elongated deformable articles |
US3521637A (en) * | 1967-11-28 | 1970-07-28 | Nelson J Waterbury | Tampon or similar sanitary napkin containing vitamin a |
US3760808A (en) * | 1969-12-01 | 1973-09-25 | K Bleuer | Tampon applicator assembly |
US3796219A (en) * | 1971-03-24 | 1974-03-12 | Kimberly Clark Co | Coated tampon |
US3815600A (en) * | 1972-07-24 | 1974-06-11 | H Groves | Vaginal medicator |
US3818911A (en) * | 1972-05-11 | 1974-06-25 | E Fournier | Medicament and swab type applicators |
US3830237A (en) * | 1973-03-27 | 1974-08-20 | Kimberly Clark Co | Method for scenting tampons and product obtained thereby |
US3831605A (en) * | 1973-01-26 | 1974-08-27 | E Fournier | Multipurpose applicators |
US3884233A (en) * | 1973-09-04 | 1975-05-20 | Betty Louise Summey | Tampon and suppository combination |
US3885564A (en) * | 1972-07-24 | 1975-05-27 | Harvey H Groves | Vaginal medicator |
US3902493A (en) * | 1974-05-13 | 1975-09-02 | Procter & Gamble | Medicated catamenial tampon |
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3949752A (en) * | 1973-08-31 | 1976-04-13 | Beverly Van Stee | Menstrual device for an animal |
US4016270A (en) * | 1975-10-31 | 1977-04-05 | Alza Corporation | Method for treating dysmenorrhea with a uterine therapeutic system |
US4077409A (en) * | 1974-01-24 | 1978-03-07 | Murray Jerome L | Encapsulated catamenial device |
US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4159719A (en) * | 1977-05-09 | 1979-07-03 | Xomed, Inc. | Moisture-expandable ear wick |
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4186742A (en) * | 1978-06-09 | 1980-02-05 | Donald Enterprises, Inc. | Contraceptive-antivenereal disease tampon |
US4260570A (en) * | 1979-05-11 | 1981-04-07 | Block Drug Company Inc. | Method and apparatus for making a vaginal cleaning device |
US4271835A (en) * | 1978-05-17 | 1981-06-09 | Kcdp Corporation | Fluid-expansible contraceptive tampon and applicator |
US4286596A (en) * | 1978-02-27 | 1981-09-01 | Herbert Rubinstein | Tampon containing a liquid medicant |
US4308867A (en) * | 1979-03-23 | 1982-01-05 | Roseman Theodore J | Two-member medicated device for rate-controlled administration of lipophilic pharmaceuticals |
US4309997A (en) * | 1978-06-09 | 1982-01-12 | Donald Jack W | Contraceptive and/or antivenereal disease tampon |
US4312348A (en) * | 1979-07-13 | 1982-01-26 | Dr. Carl Hahn, G.M.B.H. | Tampon pack with a lubricant depot in the packaging |
US4317447A (en) * | 1979-07-19 | 1982-03-02 | Ortho Pharmaceutical Corporation | Drug delivery system |
US4318405A (en) * | 1980-07-24 | 1982-03-09 | Sneider Vincent R | Tampon and drug delivery device |
US4328804A (en) * | 1978-11-16 | 1982-05-11 | Kazuo Shimatani | Hygienic tampon and tampon applicator |
US4340055A (en) * | 1980-10-01 | 1982-07-20 | Sneider Vincent R | Impregnated tampon and method of fabricating same |
US4341211A (en) * | 1981-09-08 | 1982-07-27 | Kline Larry H | Lubricating object applicator |
US4341215A (en) * | 1980-09-04 | 1982-07-27 | Tampax Incorporated | Absorbent device |
US4373631A (en) * | 1979-04-24 | 1983-02-15 | Dr. Carl Hahn G.M.B.H. | Tampon pack especially for a coated tampon containing medicaments |
US4383993A (en) * | 1980-05-30 | 1983-05-17 | University Of Kentucky Research Foundation | Nasal dosage forms containing natural female sex hormones |
US4393871A (en) * | 1977-06-27 | 1983-07-19 | Vli Corporation | Vaginal device |
US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
US4405323A (en) * | 1981-09-08 | 1983-09-20 | Sidney Auerbach | Sanitary napkin |
US4439194A (en) * | 1981-09-08 | 1984-03-27 | Merck & Co., Inc. | Water and drug delivery system for suppository use |
US4582717A (en) * | 1982-02-06 | 1986-04-15 | Bayer Aktiengesellschaft | Process for production of vaginal tampons containing pharmaceutical active compound |
US4601714A (en) * | 1983-07-07 | 1986-07-22 | Burnhill Michael S | Vaginal device |
US4610659A (en) * | 1983-01-28 | 1986-09-09 | Johnson & Johnson G.M.B.H. | Tampon pack |
US4649075A (en) * | 1984-08-09 | 1987-03-10 | Leonora Jost | Transdermal and transmucosal vortexed foam devices and the method of making |
US4795422A (en) * | 1987-08-03 | 1989-01-03 | Henry Dreyfuss Associates | System for containment and digital insertion of suppositories and other objects |
US4923440A (en) * | 1987-09-30 | 1990-05-08 | Henry Dreyfuss Associates | Device for containment and insertion of tampons and other objects |
US4922928A (en) * | 1988-08-17 | 1990-05-08 | Michael Burnhill | Vaginal device |
US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
US5041080A (en) * | 1988-04-12 | 1991-08-20 | Sumie Shimatani | Tampon applicator |
US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
US5201326A (en) * | 1989-08-30 | 1993-04-13 | Vp-Schickedanz | Tampon for medical or hygienic purposes and method of making the same |
US5213566A (en) * | 1991-07-02 | 1993-05-25 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
US5295984A (en) * | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
US5299581A (en) * | 1990-07-05 | 1994-04-05 | Donnell John T | Intravaginal device |
US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5330427A (en) * | 1991-07-02 | 1994-07-19 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
US5383891A (en) * | 1991-04-08 | 1995-01-24 | Walker; Marshall D. | Nose bleed kid |
US5393528A (en) * | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
US5417224A (en) * | 1993-05-19 | 1995-05-23 | Advanced Medical Instruments, Inc. | Tampon and method for manufacturing the same |
US5527534A (en) * | 1992-10-21 | 1996-06-18 | Gynetech Laboratories, Ltd. | Vaginal sponge delivery system |
US5542914A (en) * | 1993-02-12 | 1996-08-06 | Kimberly-Clark Corporation | Encapsulated tampon with an applicator |
US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
US5646206A (en) * | 1993-04-23 | 1997-07-08 | The United States Of America As Represented By The Secretary Of Agriculture | Films fabricated from mixtures of pectin and poly(vinyl alchohol) |
US5769813A (en) * | 1995-06-07 | 1998-06-23 | Peiler; Frances K. | Indicator tampon applicator |
US5788980A (en) * | 1995-11-01 | 1998-08-04 | Roussel Uclaf | Intravaginal drug delivery device |
US5912006A (en) * | 1996-08-28 | 1999-06-15 | Eboc, Inc. | Compositions and methods for alleviating discomforting menstrual pain |
US6036666A (en) * | 1996-10-09 | 2000-03-14 | Peiler; Frances K. | Tampon applicator |
US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
US6086909A (en) * | 1997-06-11 | 2000-07-11 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
US6096332A (en) * | 1998-06-30 | 2000-08-01 | Mcneil-Ppc, Inc. | Adding pharmaceutically active compounds to substrates |
US6200288B1 (en) * | 1997-08-26 | 2001-03-13 | Queen's University At Kingston | Everting toroid device for insertion into a body cavity |
US6203514B1 (en) * | 1999-02-19 | 2001-03-20 | Charles K. Clifford | Tampon containing a medicinal liquid imparted from a tampon irrigation syringe |
US6264972B1 (en) * | 1999-11-10 | 2001-07-24 | Tolland Development Company, Llc | Tampon |
US6264638B1 (en) * | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
US6416779B1 (en) * | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US6524269B2 (en) * | 2000-08-02 | 2003-02-25 | Mcnamara Sean P. | Lubricated tampon |
US6526980B1 (en) * | 1999-08-26 | 2003-03-04 | West Virginia University | Cervical drug delivery system |
US6558362B1 (en) * | 1999-02-03 | 2003-05-06 | Bernard Chaffringeon | Disposable device for transferring an active liquid into a body cavity |
US6582389B2 (en) * | 2000-12-20 | 2003-06-24 | Mcneil-Ppc, Inc. | Applicator for delivering bulky devices |
US6592540B2 (en) * | 2001-03-12 | 2003-07-15 | Decarlo Tracy | Tampon applicator with lubricated tip |
US20030139709A1 (en) * | 2002-01-10 | 2003-07-24 | Gehling Steven Craig | Medicated tampon |
US20030144639A1 (en) * | 1997-06-11 | 2003-07-31 | Gehling Steven Craig | Medicated tampon |
US20040043061A1 (en) * | 2000-09-15 | 2004-03-04 | Leon Daniel S. | Dissolvable films comprising suspended, non-soluble pharmaceutically active ingredients, apparatus and methods for their manufacture and use |
US6888043B2 (en) * | 2001-12-21 | 2005-05-03 | Kimberly-Clark Worldwide, Inc. | Feminine care products for the delivery of therapeutic substances |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US639864A (en) | 1899-08-03 | 1899-12-26 | Minnie Von Raitz | Medical tampon. |
US1395295A (en) | 1918-01-24 | 1921-11-01 | Pond Edmund Morse | Medicated tampon |
US1538678A (en) | 1923-02-24 | 1925-05-19 | Joseph S Blinn | Suppository injector |
US1887526A (en) | 1931-11-02 | 1932-11-15 | Joseph M Spielberg | Medical tampon |
US2696456A (en) | 1950-04-24 | 1954-12-07 | Lambert Company | Dual element suppository |
US2854978A (en) | 1956-07-24 | 1958-10-07 | Ortho Pharma Corp | Applicator |
US3916898A (en) | 1964-05-20 | 1975-11-04 | Searle & Co | Administration of medicaments and the like |
US3415249A (en) | 1966-01-07 | 1968-12-10 | Stanley Drug Products Inc | Suppository |
US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
DE2024930A1 (en) | 1970-05-22 | 1971-12-09 | Roland Arzneimittel GmbH, 4300 Essen | Medicated tampons - for internal treatment |
DE2146092A1 (en) | 1971-05-05 | 1973-03-22 | Ruppert & Gutmann Ohg | IMPROVED INTESTINAL SUCTION DEVICE |
US3762414A (en) | 1971-11-17 | 1973-10-02 | M Burnhill | Vaginal sponge |
US3791385A (en) | 1972-10-16 | 1974-02-12 | A Davis | Catamenial device and applicator thereof |
US3921636A (en) | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
DE2309575A1 (en) | 1973-02-26 | 1974-09-05 | J Matthias Dr Wenderlein | Impregnated vaginal tampons - for protection against infection by acidity control |
US3995636A (en) | 1974-01-24 | 1976-12-07 | Murray Jerome L | Constrained catamenial device employing adhesive coating |
US3918452A (en) | 1974-08-01 | 1975-11-11 | Edward Cornfeld | Tampons impregnated with contraceptive compositions |
US3995634A (en) | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal cavity dispensing means and method |
US3995633A (en) | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
US3991760A (en) | 1975-12-02 | 1976-11-16 | The Procter & Gamble Company | Vaginal medicament dispensing means |
GB1605082A (en) | 1977-06-27 | 1981-12-16 | Vorhauer Lab | Sponge-like structure |
US4424054A (en) | 1978-05-17 | 1984-01-03 | Kcdp Corporation | Fluid-expansible contraceptive tampon and applicator |
US4553965A (en) | 1978-05-17 | 1985-11-19 | Shepard Conn | Fluid-expansible contraceptive tampon and applicator |
US4237888A (en) | 1979-03-23 | 1980-12-09 | The Upjohn Company | Two-membrane medicated device for rate-controlled administration of prostaglandins |
EP0071599A1 (en) | 1981-01-23 | 1983-02-16 | Kcdp Corporation | Fluid expansible contraceptive tampon and applicator |
US4421504A (en) | 1981-09-08 | 1983-12-20 | Kline Larry H | Lubricating object injector utilizing a single plunger |
JPS58134019A (en) | 1982-02-05 | 1983-08-10 | Ono Pharmaceut Co Ltd | Slow-releasing triple-layered film pharmaceutical containing prostaglandin and its preparation |
US4551148A (en) | 1982-09-07 | 1985-11-05 | Kv Pharmaceutical Company | Vaginal delivery systems and their methods of preparation and use |
FR2536988A1 (en) | 1982-12-02 | 1984-06-08 | Pasquini Michel | ANTISEPTIC PERIODIC PAD |
DE3248152A1 (en) | 1982-12-27 | 1984-06-28 | Henkel KGaA, 4000 Düsseldorf | Applicator tampon |
US4560549A (en) | 1983-08-24 | 1985-12-24 | Lever Brothers Company | Method of relieving pain and inflammatory conditions employing substituted salicylamides |
US4693705A (en) | 1984-04-09 | 1987-09-15 | Gero Ilona B | Vaginal contraceptive system |
US4979947A (en) | 1985-10-10 | 1990-12-25 | Berman Irwin R | Encapsulated expandible continence device |
US4690671A (en) | 1985-10-15 | 1987-09-01 | Coleman Mary T | Lubricated tampon inserter |
DE3584523D1 (en) | 1985-10-31 | 1991-11-28 | Kv Pharm Co | SYSTEM FOR RELEASING SUBSTANCES IN THE VAGINA. |
US4871542A (en) | 1987-04-30 | 1989-10-03 | Ferring Service Center, N.V. | Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract |
US5070889A (en) | 1988-10-13 | 1991-12-10 | Leveen Harry H | Contraceptive sponge and tampon |
FR2665357B1 (en) | 1990-07-31 | 1995-03-31 | Aiache Jean Marc | PROCESS FOR THE PREPARATION OF A BIO-ADHESIVE GALENIC FORM AND GALENIC FORM THUS PREPARED. |
US5273521A (en) | 1992-08-26 | 1993-12-28 | Peiler Frances K | Tampon applicator for delivery of a medicament |
US6328991B1 (en) | 1992-10-21 | 2001-12-11 | John Myhling | Composition and method for prevention of sexually transmitted diseases, including aids |
GB2277447A (en) | 1993-04-13 | 1994-11-02 | Beeson & Sons Ltd | Tampon applicator |
UA39965C2 (en) | 1993-12-03 | 2001-07-16 | Лайфор Леборетріз Лтд | VIRUSIC, BACTERICIDAL AND DESTRUCTIVE SPERMATOSES VAGINAL PRODUCT AND VAGINAL SUPPOSITORY (OPTIONS) |
FR2726992B1 (en) | 1994-11-21 | 1997-06-27 | Sgro Jean Claude | DEVICE FOR THE SAMPLING AND ANALYSIS OF BIOLOGICAL LIQUIDS |
US5683358A (en) | 1994-12-29 | 1997-11-04 | Kimberly-Clark Worldwide, Inc. | Applicator for holding and dispensing a substance |
US5656283A (en) | 1995-06-08 | 1997-08-12 | Ortho Pharmaceutical Corporation | In-situ lyophilization of vaginal suppository in unit dose applicator and resultant product |
EP0749741B1 (en) | 1995-06-22 | 1999-09-08 | Medivice Limited Company | Tampon applicator |
US5741525A (en) | 1995-10-24 | 1998-04-21 | Marshall University Research Corporation | Vaginal pharmaceutical hydrogen peroxide composition |
WO1997019680A1 (en) | 1995-11-28 | 1997-06-05 | Christophe Boyer | Therapeutical use of beta-mimetic agents for the transmucosal treatment of dysmenorrhoea |
AU2459497A (en) | 1996-05-31 | 1998-01-05 | Research And Development Institute, Inc. | Urinary medical devices |
FR2753630A1 (en) | 1996-09-20 | 1998-03-27 | Montmarin Jean Luc De | Use of feminine sanitary protection products |
US5993856A (en) | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
US6572874B1 (en) | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
DE69819748T2 (en) | 1997-09-12 | 2004-09-30 | Columbia Laboratories (Bermuda) Ltd. | MEDICINES FOR TREATING DYSMENORRHEA AND PREVIOUS BLIES |
US5988386A (en) | 1998-03-20 | 1999-11-23 | Morrow; Jacqueline M. | Feminine hygiene storage unit |
WO1999048453A1 (en) | 1998-03-20 | 1999-09-30 | Morrow Jacqueline M | Feminine hygiene storage unit |
ES2151397B1 (en) | 1998-06-03 | 2001-07-01 | Martinez Moreno Julio Fernando | APPLICATION UNIT OF A DOSE OF CHEMICAL AND SIMILAR PRODUCTS. |
GB2369063B (en) | 1999-04-29 | 2003-07-16 | Peter James Brian Lamb | Device for depositing a non-flowable object or a non-flowable medicament in a body cavity |
EP1250113B1 (en) | 2000-01-18 | 2004-04-21 | Hugo Cimber | Tampon applicator |
GB0009914D0 (en) | 2000-04-20 | 2000-06-07 | Metris Therapeutics Limited | Device |
US20040112769A1 (en) | 2000-12-23 | 2004-06-17 | Lisa Jayne Perry | Packaging system |
US6946501B2 (en) | 2001-01-31 | 2005-09-20 | The Procter & Gamble Company | Rapidly dissolvable polymer films and articles made therefrom |
WO2003007862A2 (en) | 2001-07-19 | 2003-01-30 | Peter James Brian Lamb | A tampon |
US6610025B2 (en) | 2001-08-06 | 2003-08-26 | The Procter & Gamble Company | Tampon applicator arrangement |
US6899700B2 (en) | 2001-08-29 | 2005-05-31 | Kimberly-Clark Worldwide, Inc. | Therapeutic agent delivery tampon |
US20030114394A1 (en) | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
US7306812B2 (en) | 2003-05-09 | 2007-12-11 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US7744556B2 (en) | 2005-03-25 | 2010-06-29 | Kimberly-Clark Worldwide, Inc. | Delivery tube assembly for an applicator |
US7527614B2 (en) | 2005-03-25 | 2009-05-05 | Kimberly-Clark Worldwide, Inc. | Protective tube for a medicated tampon |
US7919453B2 (en) | 2005-03-25 | 2011-04-05 | Kimberly-Clark Worldwide, Inc. | Dosage cap assembly for an applicator |
US7993667B2 (en) | 2005-03-25 | 2011-08-09 | Kimberly-Clark Worldwide, Inc. | Methods of manufacturing a medicated tampon assembly |
-
2005
- 2005-04-28 US US11/116,643 patent/US7708726B2/en not_active Expired - Fee Related
-
2006
- 2006-03-30 EP EP06749094A patent/EP1890758B1/en not_active Expired - Fee Related
- 2006-03-30 WO PCT/US2006/012122 patent/WO2006115699A1/en active Application Filing
- 2006-03-30 MX MX2007013448A patent/MX2007013448A/en active IP Right Grant
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US749220A (en) * | 1904-01-12 | Medicated tampon | ||
US706778A (en) * | 1901-12-03 | 1902-08-12 | Edmund Morse Pond | Medicated tampon. |
US812768A (en) * | 1903-07-24 | 1906-02-13 | Edmund M Pond | Medicated tampon. |
US812769A (en) * | 1904-07-19 | 1906-02-13 | Edmund M Pond | Medicated tampon. |
US812770A (en) * | 1904-09-12 | 1906-02-13 | Edmund Morse Pond | Medicated tampon. |
US1234383A (en) * | 1916-11-17 | 1917-07-24 | Edmund Morse Pond | Medicated tampon. |
US2473368A (en) * | 1944-02-25 | 1949-06-14 | Flintermann Gerhard | Suppository |
US2739593A (en) * | 1954-02-25 | 1956-03-27 | Zonite Products Corp | Medicated vaginal tampons |
US2922423A (en) * | 1956-05-10 | 1960-01-26 | Kimberly Clark Co | Tampon ejector |
US3086527A (en) * | 1959-03-18 | 1963-04-23 | David C Forrest | Medical applicator |
US3515138A (en) * | 1967-07-05 | 1970-06-02 | Josef Hochstrasser | Process and apparatus for treating elongated deformable articles |
US3521637A (en) * | 1967-11-28 | 1970-07-28 | Nelson J Waterbury | Tampon or similar sanitary napkin containing vitamin a |
US3760808A (en) * | 1969-12-01 | 1973-09-25 | K Bleuer | Tampon applicator assembly |
US3796219A (en) * | 1971-03-24 | 1974-03-12 | Kimberly Clark Co | Coated tampon |
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3818911A (en) * | 1972-05-11 | 1974-06-25 | E Fournier | Medicament and swab type applicators |
US3815600A (en) * | 1972-07-24 | 1974-06-11 | H Groves | Vaginal medicator |
US3885564A (en) * | 1972-07-24 | 1975-05-27 | Harvey H Groves | Vaginal medicator |
US3831605A (en) * | 1973-01-26 | 1974-08-27 | E Fournier | Multipurpose applicators |
US3830237A (en) * | 1973-03-27 | 1974-08-20 | Kimberly Clark Co | Method for scenting tampons and product obtained thereby |
US3949752A (en) * | 1973-08-31 | 1976-04-13 | Beverly Van Stee | Menstrual device for an animal |
US3884233A (en) * | 1973-09-04 | 1975-05-20 | Betty Louise Summey | Tampon and suppository combination |
US4077409A (en) * | 1974-01-24 | 1978-03-07 | Murray Jerome L | Encapsulated catamenial device |
US4077408A (en) * | 1974-01-24 | 1978-03-07 | Murray Jerome L | Catamenial device employing polymeric constraining means |
US3902493A (en) * | 1974-05-13 | 1975-09-02 | Procter & Gamble | Medicated catamenial tampon |
US4016270A (en) * | 1975-10-31 | 1977-04-05 | Alza Corporation | Method for treating dysmenorrhea with a uterine therapeutic system |
US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4160020A (en) * | 1975-11-24 | 1979-07-03 | Alza Corporation | Therapeutic device for osmotically dosing at controlled rate |
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4159719A (en) * | 1977-05-09 | 1979-07-03 | Xomed, Inc. | Moisture-expandable ear wick |
US4393871A (en) * | 1977-06-27 | 1983-07-19 | Vli Corporation | Vaginal device |
US4286596A (en) * | 1978-02-27 | 1981-09-01 | Herbert Rubinstein | Tampon containing a liquid medicant |
US4271835A (en) * | 1978-05-17 | 1981-06-09 | Kcdp Corporation | Fluid-expansible contraceptive tampon and applicator |
US4186742A (en) * | 1978-06-09 | 1980-02-05 | Donald Enterprises, Inc. | Contraceptive-antivenereal disease tampon |
US4309997A (en) * | 1978-06-09 | 1982-01-12 | Donald Jack W | Contraceptive and/or antivenereal disease tampon |
US4328804A (en) * | 1978-11-16 | 1982-05-11 | Kazuo Shimatani | Hygienic tampon and tampon applicator |
US4308867A (en) * | 1979-03-23 | 1982-01-05 | Roseman Theodore J | Two-member medicated device for rate-controlled administration of lipophilic pharmaceuticals |
US4373631A (en) * | 1979-04-24 | 1983-02-15 | Dr. Carl Hahn G.M.B.H. | Tampon pack especially for a coated tampon containing medicaments |
US4260570A (en) * | 1979-05-11 | 1981-04-07 | Block Drug Company Inc. | Method and apparatus for making a vaginal cleaning device |
US4312348A (en) * | 1979-07-13 | 1982-01-26 | Dr. Carl Hahn, G.M.B.H. | Tampon pack with a lubricant depot in the packaging |
US4317447A (en) * | 1979-07-19 | 1982-03-02 | Ortho Pharmaceutical Corporation | Drug delivery system |
US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
US4383993A (en) * | 1980-05-30 | 1983-05-17 | University Of Kentucky Research Foundation | Nasal dosage forms containing natural female sex hormones |
US4318405A (en) * | 1980-07-24 | 1982-03-09 | Sneider Vincent R | Tampon and drug delivery device |
US4341215A (en) * | 1980-09-04 | 1982-07-27 | Tampax Incorporated | Absorbent device |
US4340055A (en) * | 1980-10-01 | 1982-07-20 | Sneider Vincent R | Impregnated tampon and method of fabricating same |
US4439194A (en) * | 1981-09-08 | 1984-03-27 | Merck & Co., Inc. | Water and drug delivery system for suppository use |
US4341211A (en) * | 1981-09-08 | 1982-07-27 | Kline Larry H | Lubricating object applicator |
US4405323A (en) * | 1981-09-08 | 1983-09-20 | Sidney Auerbach | Sanitary napkin |
US4582717A (en) * | 1982-02-06 | 1986-04-15 | Bayer Aktiengesellschaft | Process for production of vaginal tampons containing pharmaceutical active compound |
US4610659A (en) * | 1983-01-28 | 1986-09-09 | Johnson & Johnson G.M.B.H. | Tampon pack |
US4601714A (en) * | 1983-07-07 | 1986-07-22 | Burnhill Michael S | Vaginal device |
US4649075A (en) * | 1984-08-09 | 1987-03-10 | Leonora Jost | Transdermal and transmucosal vortexed foam devices and the method of making |
US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
US4795422A (en) * | 1987-08-03 | 1989-01-03 | Henry Dreyfuss Associates | System for containment and digital insertion of suppositories and other objects |
US4923440A (en) * | 1987-09-30 | 1990-05-08 | Henry Dreyfuss Associates | Device for containment and insertion of tampons and other objects |
US5041080A (en) * | 1988-04-12 | 1991-08-20 | Sumie Shimatani | Tampon applicator |
US4922928A (en) * | 1988-08-17 | 1990-05-08 | Michael Burnhill | Vaginal device |
US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
US5201326A (en) * | 1989-08-30 | 1993-04-13 | Vp-Schickedanz | Tampon for medical or hygienic purposes and method of making the same |
US5295984A (en) * | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
US6264638B1 (en) * | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
US5299581A (en) * | 1990-07-05 | 1994-04-05 | Donnell John T | Intravaginal device |
US5383891A (en) * | 1991-04-08 | 1995-01-24 | Walker; Marshall D. | Nose bleed kid |
US5213566A (en) * | 1991-07-02 | 1993-05-25 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
US5330427A (en) * | 1991-07-02 | 1994-07-19 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
US5393528A (en) * | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
US5529782A (en) * | 1992-05-07 | 1996-06-25 | Staab; Robert | Dissolvable device for contraception or delivery of medication |
US5527534A (en) * | 1992-10-21 | 1996-06-18 | Gynetech Laboratories, Ltd. | Vaginal sponge delivery system |
US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5542914A (en) * | 1993-02-12 | 1996-08-06 | Kimberly-Clark Corporation | Encapsulated tampon with an applicator |
US5646206A (en) * | 1993-04-23 | 1997-07-08 | The United States Of America As Represented By The Secretary Of Agriculture | Films fabricated from mixtures of pectin and poly(vinyl alchohol) |
US5417224A (en) * | 1993-05-19 | 1995-05-23 | Advanced Medical Instruments, Inc. | Tampon and method for manufacturing the same |
US5769813A (en) * | 1995-06-07 | 1998-06-23 | Peiler; Frances K. | Indicator tampon applicator |
US5788980A (en) * | 1995-11-01 | 1998-08-04 | Roussel Uclaf | Intravaginal drug delivery device |
US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
US5912006A (en) * | 1996-08-28 | 1999-06-15 | Eboc, Inc. | Compositions and methods for alleviating discomforting menstrual pain |
US6036666A (en) * | 1996-10-09 | 2000-03-14 | Peiler; Frances K. | Tampon applicator |
US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
US6086909A (en) * | 1997-06-11 | 2000-07-11 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
US20030144639A1 (en) * | 1997-06-11 | 2003-07-31 | Gehling Steven Craig | Medicated tampon |
US6416779B1 (en) * | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US6103256A (en) * | 1997-06-24 | 2000-08-15 | Hoechst Marion Roussel | Intravaginal drug delivery device |
US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
US6200288B1 (en) * | 1997-08-26 | 2001-03-13 | Queen's University At Kingston | Everting toroid device for insertion into a body cavity |
US6096332A (en) * | 1998-06-30 | 2000-08-01 | Mcneil-Ppc, Inc. | Adding pharmaceutically active compounds to substrates |
US6558362B1 (en) * | 1999-02-03 | 2003-05-06 | Bernard Chaffringeon | Disposable device for transferring an active liquid into a body cavity |
US6203514B1 (en) * | 1999-02-19 | 2001-03-20 | Charles K. Clifford | Tampon containing a medicinal liquid imparted from a tampon irrigation syringe |
US6526980B1 (en) * | 1999-08-26 | 2003-03-04 | West Virginia University | Cervical drug delivery system |
US6264972B1 (en) * | 1999-11-10 | 2001-07-24 | Tolland Development Company, Llc | Tampon |
US6524269B2 (en) * | 2000-08-02 | 2003-02-25 | Mcnamara Sean P. | Lubricated tampon |
US20040043061A1 (en) * | 2000-09-15 | 2004-03-04 | Leon Daniel S. | Dissolvable films comprising suspended, non-soluble pharmaceutically active ingredients, apparatus and methods for their manufacture and use |
US6582389B2 (en) * | 2000-12-20 | 2003-06-24 | Mcneil-Ppc, Inc. | Applicator for delivering bulky devices |
US6592540B2 (en) * | 2001-03-12 | 2003-07-15 | Decarlo Tracy | Tampon applicator with lubricated tip |
US6888043B2 (en) * | 2001-12-21 | 2005-05-03 | Kimberly-Clark Worldwide, Inc. | Feminine care products for the delivery of therapeutic substances |
US20030139709A1 (en) * | 2002-01-10 | 2003-07-24 | Gehling Steven Craig | Medicated tampon |
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US7862533B2 (en) | 2002-02-22 | 2011-01-04 | Playtex Products, Inc. | Multiple-component tampon applicator |
US7727210B2 (en) * | 2002-02-22 | 2010-06-01 | Playtex Products, Inc. | Multiple-component tampon applicator |
US20050215939A1 (en) * | 2002-02-22 | 2005-09-29 | Playtex Products, Inc. | Multiple-component tampon applicator |
US20080004563A1 (en) * | 2002-02-22 | 2008-01-03 | Playtex Products, Inc. | Multiple-component tampon applicator |
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US20050215940A1 (en) * | 2002-02-22 | 2005-09-29 | Playtex Products, Inc. | Multiple-component tampon applicator |
US8556845B2 (en) | 2002-02-22 | 2013-10-15 | Playtex Products, Llc | Multiple-component tampon applicator |
US20070128254A1 (en) * | 2005-12-07 | 2007-06-07 | Heuer Daniel J | Methods of attaching a dosage form to a medicated tampon assembly |
US7666160B2 (en) * | 2006-12-29 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery device |
US8088093B2 (en) * | 2008-08-07 | 2012-01-03 | Ottuso Patrick | Wound penetrating hemostatic device impregnated with coagulant, antibiotic and/or anesthetic |
US20100036308A1 (en) * | 2008-08-07 | 2010-02-11 | Ottuso Patrick | Wound penetrating hemostatic device impregnated with coagulant, antibiotic and/or anesthetic |
US11135106B2 (en) | 2012-06-25 | 2021-10-05 | Edgewell Personal Care Brands, Llc | Package assembly for or with a tampon applicator |
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US10575999B2 (en) | 2012-06-25 | 2020-03-03 | Edgewell Personal Care Brands, Llc. | Package assembly for or with a tampon applicator |
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US20210220184A1 (en) * | 2018-08-03 | 2021-07-22 | Anne's Day Ltd | Absorbent tampon for treatment of menstrual symptoms |
US20210322740A1 (en) * | 2020-04-15 | 2021-10-21 | The Procter & Gamble Company | Methods and applicators for treating vaginal conditions |
US11565096B2 (en) | 2021-01-14 | 2023-01-31 | Herphoric, Inc. | Delivery system for a pharmaceutical, holistic or medicinal component |
Also Published As
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MX2007013448A (en) | 2008-01-21 |
US7708726B2 (en) | 2010-05-04 |
EP1890758A1 (en) | 2008-02-27 |
EP1890758B1 (en) | 2012-06-06 |
WO2006115699A1 (en) | 2006-11-02 |
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