US20060238702A1 - Ophthalmic lens combinations - Google Patents
Ophthalmic lens combinations Download PDFInfo
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- US20060238702A1 US20060238702A1 US11/456,521 US45652106A US2006238702A1 US 20060238702 A1 US20060238702 A1 US 20060238702A1 US 45652106 A US45652106 A US 45652106A US 2006238702 A1 US2006238702 A1 US 2006238702A1
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Classifications
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
Definitions
- the present invention relates generally to devices and methods for correcting vision and more particularly to ophthalmic device combinations for providing accommodative vision.
- the human eye includes an anterior chamber between the cornea and iris, a posterior chamber including a capsular bag containing a crystalline lens, a ciliary muscle, a vitreous chamber behind the lens containing the vitreous humor, and a retina at the rear of this chamber.
- the human eye has a natural accommodation ability. The contraction and relaxation of the ciliary muscle provides the eye with near, intermediate and distant vision. This ciliary muscle action shapes the natural crystalline lens to the appropriate optical configuration for focusing light rays entering the eye on the retina.
- a conventional, monofocal IOL can be placed in the postelior chamber.
- Such a conventional IOL has very limited, if any, accommodating ability.
- the wearer of such an IOL continues to require the ability to view both near and far (distant) objects.
- Corrective spectacles may be employed as a useful solution.
- Multifocal IOLs without accommodating movement have also been used to provide near/far vision correction.
- IOLs Inventions, One problem that exists with such IOLs is that they often cannot move sufficiently to obtain the desired accommodation. The degree of accommodation has been closely related to the lens prescription of the individual patient. In addition, the presence of such lenses can result in cell growth from the capsular bag onto the optics of such lenses. Such cell growth, often referred to as posterior capsule opacification (PCO), can interfere with the clarity of the optic to the detriment of the lens wearer's vision.
- PCO posterior capsule opacification
- Another problem that can occur is that of providing an intraocular lens that provides a predetermined amount of accommodative power for a wide variety of eyes and with a relatively low amount of aberrations for both near and distant vision. This problem may arise because mechanical stresses used to change the focal length of a lens generally give rise to optical aberrations that reduce visual acuity of the eye.
- a related problem is that of determining a precise prescription for the aphakic eye prior to the surgical procedure for replacing the natural lens with an accommodative intraocular lens. This may result in implantation of an intraocular lens that is either too strong or too weak for the patient, or that does not produce enough accommodation to provide both near and distant vision.
- a similar problem may occur when the correct prescription is initially provided, but the patient's prescription changes over time.
- IOLs adapted for accommodating movement and/or deformation, which can preferably achieve an acceptable amount of accommodation and/or a reduced risk of PCO. It would also be advantageous to provide accommodating intraocular lenses or systems of ophthalmic devices that accurately provide a patient's prescription for distant and/or near vision in a way that produces little or no optical aberrations.
- Embodiments of the present invention provide distance, near and/or intermediate vision by axially moving and/or deforming one or more optical elements, for example, by deforming at least one optical surface (e.g., changing a radius of curvature or conic constant of the surface) and/or changing the thickness of the optic.
- the present combinations may be used to enhance the degree of accommodation achieved in spite of the movement and space limitations within the eye and to produce near and/or distant vision that is relatively low in optical aberrations.
- One advantage of the present combinations is the ability to standardize the prescription or optical power of the accommodating lens or optic of the combination.
- the required amount of movement and/or deformation in the eye to achieve accommodation can be substantially the same for all patients or for a particular class or category of patients.
- improved inhibition of PCO is obtained.
- the present combinations may be designed to be relatively straightforward in construction, implanted or inserted into the eye using systems and procedures which are well known in the art, and be made to function effectively with little or no additional treatments or medications being required.
- combinations of ophthalmic devices according to the present invention may also include a corrector lens or optic that is used in combination with an accommodating lens, wherein the corrector lens or optic is configured to correct monochromatic and/or a chromatic aberrations of a primary intraocular lens and/or of at least a portion of the ocular imaging system.
- intraocular lens combinations comprise a first optic body, second optic body and a movement assembly.
- the first optic body has a negative or plano optical power and is adapted to be placed in a substantially fixed position in a mammalian eye. In those cases where the first optic body has a negative optical power, it is also called the compensating optic body.
- the second optic body also called the primary optic body, has a higher optical power than the first optic body.
- the movement assembly is coupled to the second optic body and is adapted to cooperate with the eye, for example, the zonules, ciliary muscle and capsular bag of the eye, to effect accommodating movement and/or accommodating deformation of the second optic body in the eye, for example, in response to one or more ocular forces or naturally occurring actions of the eye.
- the second optic body has a high plus optical power to reduce the amount of movement, for example, axial movement, in the eye needed to provide accommodation for intermediate and near vision.
- the negative or minus optical power of the first optic body compensates for the excess plus or positive optical power in the first optic body.
- the use of such a compensating lens, that is the first optic body having a negative optical power can allow for standardization of the optical power correction in the second optic body.
- the optical power of the second optic body, that is the primary or movable optic body can be approximately equal from optic body to optic body, while the optical power of the first optic body, that is the compensating or fixed optic body, is adjusted from optic body to optic body to meet the specific vision correction needs (prescription) of each individual patient. Consequently, the required amount of movement of the second optic body in the eye can be approximately the same for all patients.
- the present ILCs provide accommodation, preferably an acceptable degree of accommodation, in spite of movement and space limitations in the eye.
- the maximum theoretical amount of axial movement for a simple disc lens having an overall diameter of 11 millimeters (mm) and an optic diameter of 5 mm that undergoes 1 mm of compression in its diameter is about 1.65 mm.
- the amount of axial movement required for a plus 15 diopter optic to provide 2.5 diopters of additional power in the spectacle plane is about 2.6 mm.
- a plus 30 diopter optic requires only 1.2 mm of axial movement to provide 2.5 diopters of additional power in the spectacle plane.
- the first or fixed optic may have a minus power to compensate for the excess plus power in the second optic.
- the present ILCs may include first and second optics with optical powers which provide a net plus optical power.
- the first optic body is provided with a minus 15 diopter optical power and the second optic body with a plus 30 diopter optical power.
- the net optical power of this ILC is approximately the sum of minus 15 diopters and plus 30 diopters or plus 15 diopters, the desired prescription for the patient in question.
- the powers of the first and second optics are only approximately additive since the net power of the combination also depends on other factors including, but not limited to, the separation of the two optics, the magnitude of the power of each individual optic body and its location in the eye and the like factors.
- the net optical power of the ILC can be adjusted or controlled even though the optical power of the second optic body is standardized or remains the same, for example, at a plus 30 diopter optical power.
- the amount of movement in the eye required to obtain a given level of accommodation is substantially the same, and preferably well within the space limitations in the eye, from patient to patient.
- the movement assembly comprises a member including a proximal end region coupled to the second optic body and a distal end region extending away from the second optic body and adapted to contact a capsular bag of the eye.
- Such movement assembly may completely circumscribe the second optic body or may be such as to only partially circumscribe the second optic body.
- the second optic body preferably is adapted to be positioned in the capsular bag of the eye.
- the first optic body may be coupled to a fixation member, or a plurality of fixation members, adapted to assist in fixating the first optic body in the eye.
- Each fixation member may have a distal end portion extending away from the first optic body.
- the distal end portion of the fixation member is adapted to be located in the capsular bag of the eye.
- the distal end portion of the fixation member may be located in contact with a sulcus of the eye.
- the distal end portion of the fixation member may be adapted to be located in an anterior chamber of the eye.
- the first optic body may be located posterior in the eye relative to the second optic body or anterior in the eye relative to the second optic body.
- the first optic body is adapted to be positioned in contact with the posterior wall of the capsular bag of the eye. This positioning of the first optic body provides for effective compensation of the plus or positive vision correction power of the second optic body.
- PCO posterior capsule opacification
- fixation member or members and the movement assembly are secured together, preferably permanently secured together.
- a single combined structure can be inserted. This reduces the need to position the first and second optics relative to each other. Put another way, this feature allows the surgeon to very effectively and conveniently position the ILC in the eye with reduced surgical trauma to the patient.
- fixation member and movement assembly may be secured, for example, fused, together at the distal end portion of the fixation member and the distal end region of the movement assembly.
- the compensating lens and primary lens are completely separate from and independent of one another, enabling them to be implanted consecutively, rather than simultaneously. This allows the lenses to be inserted through a smaller incision than would be possible with a combined structure. In the case of separate lenses, however, special care must be taken to axially align the two lenses in order to avoid decentration issues.
- ILCs comprise a first optic body having a posterior surface adapted to be positioned in contact with a posterior wall of the capsular bag of the eye; a second optic body adapted to focus light toward a retina of the eye; and a movement assembly coupled to the second optic body and adapted to cooperate with the eye to effect accommodating movement of the second optic body in the eye.
- the first optic body has a substantially piano optical power or a negative optical power.
- the first optic body of these combinations preferably is adapted to be placed in a substantially fixed position in the eye.
- the posterior surface of the first optic body advantageously is configured to substantially conform to a major portion, that is, at least about 50%, of the posterior wall of the capsular bag of the eye in which the combination is placed. More preferably, the posterior surface of the first optic body is configured to substantially conform to substantially the entire posterior wall of the capsular bag.
- Such configuration of the first optic body is very useful in inhibiting cell growth from the eye onto the first and second optics and in inhibiting PCO.
- the first optic body which contacts the posterior wall of the capsular, has a substantially plano optical power and the second optic body has a far vision correction power.
- the first optic body has a negative optical power and the second optic body has a positive optical power, so that the optical powers of the first and second optics provide a net plus optical power in the eye in which the combination is placed.
- the second, or primary, optic body is preferably placed in the capsular bag, while the first, or compensating, optic body, may be placed in the bag, the sulcus or the anterior chamber, or attached to the iris.
- the first optic body includes an anterior surface and at least one projection extending anteriorly from this anterior surface, The at least one projection is positioned to limit the posterior movement of the second optic body in the eye.
- the movement of the second optic body is effectively controlled to substantially maintain the configuration of the combination and/or to substantially maintain an advantageous spacing between the first and second optics.
- the movement assembly may be structured and functions similarly to movement assembly of the previously described ILCS.
- the first optic body may have a fixation member or members coupled thereto.
- the fixation member or members are adapted to assist in fixating the first optic body in the eye, that is in contact with the posterior wall of the capsular bag of the eye.
- the first optic body itself is configured and/or structured so that no fixation member or members are needed to maintain the first optic body in contact with the posterior wall of the capsular bag of the eye.
- the first optic body and the movement assembly of these ILCs may be secured together.
- first and second optics of the present ILCs may be made of any suitable materials.
- the first and second optics may be made of polymeric materials and, along with the movement assembly and any fixation member(s), are deformable for insertion through a small incision in the eye.
- the present movement assemblies are sufficiently flexible to facilitate movement of the second optic body in the eye upon being acted upon by the eye.
- the movement assembly includes a hinge assembly that may be adapted and positioned to facilitate the accommodating movement of the second optic body.
- the second optic body preferably has a far vision correction power, more preferably such a power for infinity, in the unaccommodated state.
- methods for inserting an ILC in an eye comprise providing an ILC in accordance with the present invention, as described herein.
- the ILC is placed into the eye, for example, in the capsular bag of the eye or partly in the capsular bag of the eye, using equipment and techniques which are conventional and well known in the art.
- the ILC is placed in a rest position in the eye, for example, a position so that the eye, and in particular the ciliary muscle and zonules of the eye, effectively cooperate with the movement assembly to move the second optic body of the ILC anteriorly in the eye from the rest position to provide for positive accommodation.
- No treatments or medications, for example, to paralyze the ciliary muscle, to facilitate fibrosis or otherwise influence the position of the ILC in the eye, are required.
- the primary and compensating lenses are connected by the fixation member or members and the movement assembly, and are thus simultaneously implanted in the eye.
- the primary lens is implanted first and centered about the optical axis.
- the compensating lens is then inserted anteriorly of the primary lens and optically aligned with the primary lens.
- This latter embodiment may require a smaller incision than that required for the unitary combination of the former embodiment.
- this embodiment allows for refractive measurements to be made after the primary lens has been implanted, so that any new refractive errors that may have been introduced as a result of the surgery itself can be taken into account, and a more accurate prescription for the compensating lens can be obtained.
- the first and second optics and the movement assembly are deformed prior to being placed into the eye.
- the ILC in combination with the eye, provides the mammal or human wearing the ILC with effective accommodation, preferably with reduced risk of PCO.
- the ILC in the unaccommodated state, the ILC preferably provides the mammal or human wearing the ILC with far vision correction.
- an accommodating ophthalmic device comprises a primary optic and supplemental optic.
- the primary optic is configured for placement in an eye of a subject or patient having a basic prescription (e.g., a basic prescription for distant vision or near vision) and has a base optical power that is selected to at least partially provide the basic prescription.
- the base optical power is selected to be within 8 Diopters of the basic prescription, preferably within 4 Diopter of the basic prescription, and even more preferably within 2 Diopters of the basic prescription.
- the supplemental optic has an optical power that is selected to adjust or compensate for the base optical power and may be selected to have an optical power that is within a range of about ⁇ 4 Diopters to +4 Diopters.
- the supplemental optic and the primary optic preferably have a combined optical power that is capable of providing the basic prescription of the patient to within 2 Diopters of the basic prescription, even more preferably within 1 Diopter of the basic prescription.
- at least one surface of the primary optic is configured to deform in response to an ocular force (e.g., contraction or relaxation of the ciliary muscle) so as to modify the combined optical power of the ophthalmic device or eye by at least I Diopter.
- the ophthalmic device may further comprise a movement assembly operably coupled to the primary optic that is structured to cooperate with the eye to effect accommodating deformation of the primary optic in response to an ocular force produced by the eye.
- the movement assembly may additionally or alternatively be configured to provide accommodating axial movement of the primary optic.
- the primary optic of the accommodating ophthalmic device may be selected in accordance to the structure of the eye into which the primary optic is to be placed.
- the supplemental optic is selected to change or adjust the optical power provided by the primary optic.
- the supplemental optic is a corrector optic that is selected to correct the primary optic or a portion of the eye and that has either no optical power or an optical power that is within a range of about ⁇ 4 Diopters to +4 Diopters.
- the corrector optic may be configured to correct a monochromatic aberration and/or a chromatic aberration of the primary optic and/or at least a portion of the eye (e.g., the cornea of the eye).
- the corrector optic may be used to correct or compensate for an astigmatic aberration, a spherical aberration, and/or a comatic aberration.
- the supplemental optic may be implanted together with the primary optic or separately from the primary optic (e.g., during a subsequent surgery from that in which the primary optic is implanted).
- the primary optic is preferably implanted within the capsular bag of the eye, but alternatively may be implanted outside the capsular bag, for example in the vicinity of the sulcus.
- the supplemental optic may also be implanted in the capsular bag in front of the primary optic; however, may alternatively be implanted anywhere in the anterior or posterior chambers of the eye.
- the primary and supplemental optic may be configured to maintain a separation between one another upon implantation within the eye or may be configured to contact one another in the eye.
- the supplemental optic may be a corneal implant configured to be disposed within the cornea or a surface profile disposed on or within the cornea, the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure).
- the supplemental optic is designed to provide a predetermined refractive outcome in terms of optical performance or image quality.
- the supplemental optic may have an overall optical power that may be combined with the optical power of the primary optic to provide near vision, distant vision, or intermediate vision.
- the supplemental optic may have no or substantially no optical power.
- the supplemental optic is a corrector optic that is selected to correct an optical aberration, for example a spherical aberration of the eye and/or at least one surface of an optic of the ophthalmic device.
- the supplemental optic is configured to favorably modify the aberrations when the primary optic is in an accommodative and/or disaccommodative state.
- the supplemental optic is configured increase the depth of focus of the eye, for example, by changing the optical power or focal length of the supplemental optic as a function of distance from the optical axis thereof.
- the supplemental optic is configured to produce two or more simultaneous foci (e.g., a bifocal or multifocal lens).
- the primary optic, the supplemental optic, and/or the corrector optic are part of a system or set of intraocular lenses for insertion into an eye.
- the set of intraocular lenses may comprise a plurality of supplemental optics, each supplemental optic having a value of an optical characteristic that is different from the other supplemental optics of the plurality, at least one of the supplemental optics configured to provide, in combination with the primary optic, the basic prescription of the patient.
- the different optical characteristic may be a different optical power and/or a different amount of an optical aberration or some other optical characteristic (e.g., a different first order diffraction efficiency of a multifocal phase plate).
- FIG. 1 is a front plan view of an ILC in accordance with the present invention.
- FIG. 2 is a cross-sectional view taken generally along line 2 - 2 of FIG. 1 .
- FIG. 3 is a cross-sectional view of an additional ILC in accordance with the present invention.
- FIG. 4 is a fragmentary sectional view of an eye in which an alternate ILC in accordance with the present invention has been implanted.
- FIG. 5 is a fragmentary sectional view, similar to FIG. 4 , in which the compensating optic body of the ILC is implanted in the anterior chamber of the eye.
- FIG. 6 is a front plan view of an intraocular lens useful in an ILC in accordance with the present invention.
- FIG. 7 is a fragmentary sectional view, similar to FIGS. 4 and 5 , in which the compensating optic body of the ILC is implanted in the capsular bag of the eye.
- FIG. 8 is a front view of a primary lens according to another embodiment of invention having accommodative ability to provide both distant and near vision.
- FIG. 9 is a cross-sectional view taken generally along line 9 - 9 of FIG. 8 .
- FIG. 10 is a cross-sectional view of an ophthalmic device according to an embodiment of the invention in an disaccommodative state, the device including the primary lens of FIG. 9 and a supplemental or corrector optic disposed within the anterior chamber of the eye.
- FIG. 11 is a cross-sectional view of the ophthalmic device shown in FIG. 10 in an accommodative state.
- FIG. 12 is block diagram of a method of providing accommodative vision according to an embodiment of the invention.
- FIG. 13 is a cross-sectional view of an ophthalmic device according to an embodiment of the invention including a primary lens of FIG. 9 and a corrector optic support by the sulcus of the eye.
- an ILC includes a first optic or optic body 12 , a second optic or optic body 14 , a disc type fixation member 16 and a disc type movement assembly 18 .
- optic or “optic body” means an optical element that may be used alone or as part of an optical system to produce an image on the retina the eye of a subject.
- optical and “optic body” are used somewhat interchangeable, with the term “optic” emphasizing more the optical characteristics of an optical element and “optic body” referring more to the use an optical element as part of an intraocular lens that may also include, for example, a base element, a movement assembly, or one or more haptics, fixation members, and/or movement members.
- An optic or optic body may have an optic power to converge or diverge incident light using the principles of refraction, diffraction, and/or reflection of light.
- the optic or optic body may have substantially no optical power and/or be used to at least partially correct or compensate for an optical aberration, for example, by varying the optical characteristics of the optical element over the surface (e.g., as a function of radius from the center of the optical element).
- the optic or optic body may combine both optical power and aberration correction characteristics into a single optical element. Examples of aberration correction are found in U.S. Pat. Nos. 6,338,559 and 6,948,818, which are herein incorporated by reference.
- the first optic body 12 has substantially piano optical power and is adapted to be held in a fixed position, for example, at least partially by the fixation member 16 .
- the posterior surface 20 of first optic body 12 is in contact with the inner posterior wall of the capsular bag of the eye. This positioning of optic body 12 is very effective in reducing or inhibiting endothelial cell growth from the capsular bag onto the first optic body 12 . In effect, the positioning of the first optic body 12 against the posterior surface of the capsular bag inhibits or reduce the risk of PCO.
- the second optic body 14 includes a distance vision correction power.
- the movement assembly 18 extends radially outwardly from second optic body 14 and fully circumscribes the second optic body 14 .
- Movement assembly 18 has a proximal end region 22 which is coupled to the second optic body 14 at first optic body periphery 24 .
- Movement assembly 18 extends radially outwardly to a distal end region 26 including a peripheral zone 28 .
- Fixation member 16 includes a distal end portion 30 including a peripheral area 32 .
- the movement assembly 18 and fixation member 16 are fused together at the peripheral zone 28 and peripheral area 32 .
- the entire ILC 10 is a single unitary structure.
- the first optic body 12 and fixation member 16 can be manufactured separately from second optic body 14 and movement assembly 18 and, after such separate manufacture, the fixation member and movement assembly can be fused together. Alternately, the entire ILC 10 can be manufactured together. Also, if desired, the first optic body 12 and fixation member 16 can be inserted into the eye separately from the second optic body 14 and movement assembly 18 . Thus, ILC 10 can comprise a plurality of separate components.
- Movement assembly 18 extends outwardly from second optic body 14 sufficiently so that the distal end region 26 , and in particular the peripheral zone 28 of the distal end region 28 , is in contact with the inner peripheral wall of the posterior capsular bag when the ILC 10 is implanted in the eye.
- the second optic body 14 when ILC 10 is at rest, the second optic body 14 is positioned vaulted anteriorly relative to the distal end region 26 of movement assembly 18 .
- the anterior surface 34 of second optic body 14 is anterior of the anterior surface 36 of movement assembly 18 at distal end region 26 and/or the posterior surface 38 of the second optic body 14 is anterior of a posterior surface 39 of the movement assembly at the distal end region 26 .
- the first and second optics 12 and 14 may be constructed of rigid biocompatible materials, such as polymethyl methacrylate (PMMA), or flexible, deformable materials, such as silicone polymeric materials, acrylic polymeric materials, hydrogel polymeric materials, and the like, which enable the optics 12 and 14 to be rolled or folded for insertion through a small incision into the eye.
- PMMA polymethyl methacrylate
- deformable materials such as silicone polymeric materials, acrylic polymeric materials, hydrogel polymeric materials, and the like, which enable the optics 12 and 14 to be rolled or folded for insertion through a small incision into the eye.
- the present ILCs can include at least one diffractive lens body, and such embodiment is included within the scope of the present invention.
- first optic body 12 has a substantially piano or zero optical power.
- Second optic body 14 is prescribed for the wearer of ILC 10 with a baseline or far (distance) diopter power for infinity.
- the wearer of ILC 10 is provided with the vision correction power of second optic body 14 with little or no contribution from the first optic body 12 .
- fixation member 16 and movement assembly 18 are integral (unitary) with and circumscribe the first and second optics 12 and 14 , respectively.
- fixation member 16 and/or movement assembly 18 can be mechanically or otherwise physically coupled to first optic body 12 and second optic body 14 , respectively.
- the fixation member 16 and/or movement assembly 18 may only partially circumscribe first and second optics 12 and 14 , respectively, and such embodiments are included within the scope of the present invention.
- the fixation member 16 and movement assembly 18 may be constructed from the same or different biocompatible materials as first and second optics 12 and 14 , and preferably are made of polymeric materials, such as polypropylene silicone polymeric materials, acrylic polymeric materials, and the like. Movement assembly 18 has sufficient strength and rigidity to be effective to transfer the force from the ciliary muscle of the eye so that the second optic body 14 is movable axially in the eye to effect accommodation.
- Movement member 18 includes a region of reduced thickness 41 located at the proximal end region 22 . This area of reduced thickness, which completely circumscribes the second optic body 14 , acts as a hinge to provide additional flexibility to the movement member 18 to extenuate or amplify the accommodating movement of second optic body 14 in response to the action of the ciliary muscle and zonules.
- fixation member 16 and movement assembly 18 preferably are deformable, in much the same manner as first and second optics 12 and 14 are deformable, to facilitate passing ILC 10 through a small incision into the eye.
- the material or materials of construction from which fixation member 16 and movement assembly 18 are made are chosen to provide such members with the desired mechanical properties, e.g., strength and/or deformability, to meet the needs of the particular application involved.
- the ILC 10 can be inserted into the capsular bag of a mammalian eye using conventional equipment and techniques, for example, after the natural crystalline lens of the eye is removed, such as by using a phacoemulsification technique.
- the ILC 10 may be rolled or folded prior to insertion into the eye, and is inserted through a small incision into the eye and is located in the capsular bag of the eye.
- the ILC 10 in the eye is located in a position in the capsular bag so that the posterior surface 20 of first optic body 12 is maintained in contact with the inner posterior wall of the capsular bag.
- positioning the first optic body 12 in contact with the posterior wall of the capsular bag reduces the risk of or inhibits cell growth from the capsular bag onto the first optic body 12 which, in turn, reduces or inhibits PCO.
- the ciliary muscle and zonules of the eye provide force sufficient to move axially second optic body 14 sufficiently to provide accommodation to the wearer of ILC 10 .
- the ILC 10 should be sized to facilitate the movement of the second optic body 14 in response to the action of the ciliary muscle and zonules of the eye in which the ILC is placed.
- the first and second optics 12 and 14 preferably have diameters in the range of about 3.5 mm to about 7 mm, more preferably in the range of about 5 mm to about 6 mm.
- the ILC 10 preferably has an overall maximum diameter, with the movement assembly 18 in the unflexed or rest state, in the range of about 8 mm to about 11 mm or about 12 mm.
- the present ILC 10 has the ability, in cooperation with the eye, to move the second optic body 14 both posteriorly and anteriorly in the eye, to provide for both distance focus and near focus, respectively.
- This movement of ILC 10 advantageously occurs in response to action of the ciliary muscle and zonules, which action is substantially similar to that which effects accommodation in an eye having a natural crystalline lens.
- the ciliary muscle and zonules require little, if any, retraining to function in accordance with the present invention.
- the movement member 18 as described herein, preferably is effective to facilitate or even enhance or extenuate the axial movement of the second optic body 14 caused by the action of the ciliary muscle and zonules to provide increased degree of accommodation.
- FIG. 3 illustrates an additional ILC, shown generally at 110 , in accordance with the present invention. Except as expressly described herein, ILC 110 is structured and functions similar to ILC 10 . Components of ILC 110 which correspond to components of ILC 10 are indicated by the same reference numeral increased by 100 .
- Lens structure 40 includes a posterior face 42 which is configured to come in contact with and substantially conform to the inner posterior surface of the capsular bag of the eye in which the ILC 110 is to be placed.
- the surface 42 which extends around the peripheral area 44 and across the center region 46 of the lens structure 40 is adapted to come in contact with and substantially conform to the inner posterior wall of the capsular bag.
- the lens structure 40 is adapted to remain in contact with this inner posterior wall of the capsular bag and to be fixed in the eye. This configuration has been found to be very effective in inhibiting cell growth from the eye onto the ILC 110 .
- the anterior surface 48 of lens structure 40 is configured to provide the lens structure with a substantially plano or zero optical power.
- Second optic body 114 is prescribed for the wearer of ILC 110 with a baseline or distance or far (distance) dioptic power for infinity. Thus, the wearer of ILC 110 is provided with a vision correction power of second optic body 114 with little or no contribution from the lens structure 40 .
- second optic body 114 has a high plus power, for example, plus 30 diopters.
- the lens structure 40 and in particular the region of the lens structure, defined by the anterior surface 48 , which extends substantially across the entire field of vision of the wearer of ILC 110 , has a minus vision correction power which is controlled to provide the correction prescription for use in the eye in which the ILC 110 is placed. For example, if this eye requires a plus 15 diopter power, the lens structure 40 has a vision correction power of approximately minus 15 diopters so that the net vision correction power of the combination of lens structure 40 and second optic body 114 , is plus 15 diopters.
- the lens structure can be made from materials described previously with regard to first optic body 12 and fixation member 16 .
- lens structure 40 One additional feature of lens structure 40 relates to the anteriorly extending projections 50 which extend from the base element 52 of lens structure 40 .
- the number of these projections 50 can range from 2 to about 6 or more.
- a continuous annulus projecting anteriorly can be provided.
- the purpose of the projections 50 or the continuous annulus is to limit the posterior movement of the second optic body 114 and movement assembly 118 . This limitation in the movement provides an additional degree of control of the ILC 110 , and prevent a collapse of the ILC 110 and maintains an advantageous degree of separation between second optic body 114 and anterior surface 48 of lens structure 40 .
- FIG. 4 illustrates the use of an alternate ILC in accordance with the present invention.
- This ILC shown generally at 60 includes a compensating IOL 61 comprising a first, or compensating, optic body 62 , and a primary IOL 63 comprising a second, or primary, optic body 64 and a movement assembly 66 .
- the compensating optic body 62 is coupled to a fixation member 68 which includes a distal end portion 70 in contact with the periphery 72 of the sulcus 73 of eye 74 .
- Fixation member 68 is a disk fixation member which completely circumscribes the compensating optic body 62 .
- disc fixation member 68 can be replaced by two or more filament fixation members or plate fixation members or other types of fixation members, many of which are conventional and well known in the art.
- Movement assembly 66 is coupled to the primary optic body 64 and completely circumscribes the primary optic body.
- the primary optic body 64 is located in the capsular bag 76 of eye 74 and is vaulted anteriorly to some extent to enhance accommodating movement of the primary optic body.
- the primary optic body 64 has a plus power higher than the power required by the basic prescription of a presbyopic patient. For instance for a patient requiring plus 15 diopters of far vision correction, primary optic body 64 might have a corrective power of plus 30 diopters.
- the compensating optic body 62 is a negative or minus lens having a minus vision correction power which is controlled to provide the correct prescription for use in eye 74 .
- the compensating optic body 62 has a vision correction power of approximately minus 15 diopters so that the net vision correction power of the combination of compensating optic body 62 and primary optic body 64 equals the patient's basic prescription of plus 15 diopters.
- the compensating optic body 62 , fixation member 68 , primary optic body 64 and movement assembly 66 can be made from materials described previously with regard to the first optic body 12 , fixation member 16 , second optic body 14 and movement assembly 18 , respectively.
- the compensating optic body 62 is shown here as a meniscus style optic body; that is, the anterior surface of the optic body is convex and the posterior surface is concave.
- other negative diopter configurations could also be used, such as plano/concave or biconcave.
- one or both of the surfaces of the compensating optic body 62 could be multifocal or aspheric to allow for additional accommodation.
- the fixation member 68 is in contact with the periphery 72 of the sulcus 73 of the eye 74 .
- This is a relatively durable component of the eye and is effective to support the fixation member 68 in maintaining the compensating optic body 62 in a fixed position.
- the movement assembly 66 cooperates with the ciliary muscle 78 and zonules 80 of eye 74 to move the second optic body 64 axially along optical axis 82 of the eye.
- the amount of axial movement achieved will vary from patient to patient depending on such parameters as capsular bag dimensions.
- the movement is preferably at least about 0.5 mm, and more preferably at least about 0.75 mm.
- the accommodation assembly should allow about 1 mm to about 1.2 mm of movement. For example, with a primary optic body 64 having a corrective power of plus 30 diopters, this amount of movement will be amplified to create an additional add power, or diopter shift, of about 1.75 to about 2.5, or possibly as high as 3.5 diopters.
- the movement assembly 66 may be configured to provide accommodative movement by producing relative motion between the optic body 64 and at least portion of the movement assembly 66 .
- the movement assembly 66 may be configured to maintain a fixed or substantially fixed relationship between the optic body 64 and the movement assembly 66 . In such embodiments, accommodation may be provided when both the movement assembly 66 and the optic body 64 move together relative to the retina of the eye as the capsular bag moves and/or changes shape during accommodation.
- FIG. 5 illustrates another ILC, shown generally at 360 , in accordance with the present invention. Except as expressly described herein, ILC 360 is structured and functions similarly to ILC 60 . Components of ILC 360 which correspond to components of ILC 60 are identified by the same reference numeral increased by 300.
- ILC 360 and ILC 60 relate to the positioning of compensating optic body 362 .
- compensating IOL 361 is located in anterior chamber 90 of eye 374 .
- Fixation member 368 is coupled to the compensating optic body 362 and extends outwardly and comes in contact with the angle 92 of eye 374 .
- the arrangement of compensating optic body 362 and fixation member 368 is such that the compensating optic body is maintained in a substantially stationary position in the anterior chamber 90 of eye 374 .
- the primary optic body 364 is adapted to be moved axially along optical axis 382 of eye 374 by the ciliary muscle 378 and zonules 380 acting on the movement assembly 366 .
- FIG. 7 Still another embodiment of an ILC according to the present invention is shown in FIG. 7 , indicated generally at 560 . Except as expressly described herein, ILC 560 is structured and functions similarly to ILC 60 . Components of ILC 560 which correspond to components of ILC 60 are identified by the same reference numeral increased by 500.
- ILC 560 differs from ILC 60 primarily in the location of the compensating IOL 561 , which is located in the capsular bag 76 with the primary optic body 564 , rather than in the sulcus or anterior chamber.
- the compensating optic body 562 would not be truly stationary since the capsular bag 76 itself typically moves about 0.4 mm during accommodation.
- axial movement of the compensating optic body 562 relative the capsular bag 76 can be limited by appropriate design of the fixation member or members 568 .
- Controlling other factors such as material selection, length, width and angulation of the fixation member or members 58 relative the compensating optic body 562 can limit the overall axial movement of the compensating optic body 562 to less than 0.5 mm which, for the purposes of this invention, can be regarded as “substantially fixed.”
- FIGS. 5, 6 , and 7 A preferred method of implanting an ILC will now be discussed. The method is equally effective for the embodiments of FIGS. 5, 6 , and 7 , but for purposes of illustration will be discussed specifically with reference to FIG. 7 .
- the primary IOL 563 is inserted through an incision in the patient's cornea and positioned in the capsular bag 76 using conventional techniques.
- the incision is less than 4 mm in length.
- the primary optic body 564 and movement assembly 566 are unitary as illustrated, they are inserted simultaneously. However, it is also possible to implant an independent movement assembly 566 first, and then insert the primary optic body in the movement assembly 566 .
- a measurement is taken to determine the location of the primary optic body 564 relative to the optical axis 82 . If desired, refractive measurements may also be made at this time to accurately determine an appropriate prescription for the compensating IOL 561 .
- the compensating IOL 561 is inserted through the same incision using conventional techniques. If the incision has closed, a new one, preferably also measuring less than 4 mm, is made before insertion. A keratoscope or similar instrument is then used to guide the surgeon in positioning the fixation member or members 568 such that compensating optic body 562 and the primary optic body 564 are axially aligned with the optical axis 82 and one another. If necessary, the primary optic body 564 may also be repositioned at this time.
- Alignment of the two optic bodies 562 and 564 is a crucial aspect of this invention, since any decentration of images will be amplified by the high diopter power of the primary optic body 564 .
- Visual confirmation of alignment can be facilitated by providing the compensating optic body 562 with a diameter D CB equal to the diameter D PB of the primary optic body 564 .
- the ILC 560 can be made less sensitive to decentration by increasing the diameter of the optic zone, that is the portion of the optic body which has corrective power, in one or both of the IOLs 561 and 563 .
- the diameters of the optic zones D PZ and D CZ in IOLS 561 and 563 should be in the high end of that range or even higher, i.e. preferably from 5 mm to 8 mm. Even more preferably, at least one of the optic zone diameters D PZ or D CZ should be in the range of about 6.5 mm to about 8 mm.
- the diameters D PB and D CB of the optic bodies 562 and 564 are preferably equal, the diameters D PZ and D CZ of the optic zones need not be.
- fixation member or members 568 Another factor influencing centration is the flexibility of fixation member or members 568 .
- the member or members 568 are sufficiently flexible to allow the surgeon to reposition them as needed during the implantation process, but stiff enough to remain in a substantially fixed axial and radial position once implanted.
- FIG. 6 illustrates a still further embodiment of an intraocular lens in accordance with the present invention.
- This intraocular lens shown generally at 400 includes an optic body 401 and four (4) equally spaced apart movement members 403 .
- Each of the movement members 403 includes a distal region 405 and a proximal region 407 which is coupled to the optic body 401 .
- a hinge for example, a linear hinge, such as a reduced thickness area 409 , is located near the proximal end 407 of each of the movement members 403 ,
- a linear hinge is particularly advantageous to achieve enhanced, or even substantially maximum theoretical, axial movement.
- the IOL 400 can be used in place of the various second optic/movement assembly subcombinations noted above.
- One distinction between IOL 400 and these other subcombinations is the use of four (4) individual movement members 403 which do not totally circumscribe the optic body 401 relative to the movement assemblies noted previously which fully circumscribe the second optics.
- the movement assemblies of the present ILCs can have other configurations, for example, which are effective to facilitate or even enhance the movement of the second optics.
- FIGS. 8-11 illustrate another embodiment of the present invention in which an ophthalmic device 600 comprises a primary optic 602 and a supplemental optic 604 .
- the optics 602 , 604 are configured for placement in an eye 607 of a patient or subject having a basic prescription (e.g., a basic prescription for distant or near vision) and are generally disposed about an optical axis 608 .
- the primary optic 602 has a base optical power P base that may be selected to provide or approximately provide the basic prescription of the subject.
- the base optical power may be selected to be within ⁇ 4 Diopters of the basic prescription, preferably within ⁇ 2 Diopters of the basic prescription, even more preferably within ⁇ 1 Diopter of the basic prescription.
- the supplemental optic 604 comprises an anterior surface 605 and a posterior surface 606 that are configured to provide a supplemental optical power P supplemental .
- the supplemental optic 604 may be configured to provide, in combination with the primary optic 602 , a combined optical power P combined (e.g., P base +P supplemental ) that is capable of providing the basic prescription of the patient.
- the supplemental optical power is selected or configured to modify the vision correction provided by the primary optic 602 by an amount that allows the combination to provide or substantially provide the basic prescription for at least one configuration of the primary optic 602 .
- the supplemental optical power may be selected such that the combined optical power is within 1 Diopter of the basic prescription.
- the primary optic 602 is configured to provide vision correction that is nearly equal to the patient's basic prescription for distant vision and the supplemental optic 604 is used to modify the vision correction provided by the primary optic 602 so as to more precisely provide the patient's basic prescription.
- the supplemental optical power of the supplemental optic 604 is less than the primary optical power of the primary optic 602 .
- the primary optic 602 may have an optical power that is greater than 20 Diopters and the base optical power is greater than the supplemental optical power by at least 10 Diopters.
- the ophthalmic device 600 is configured to produce ocular accommodation, for example, by configuring at least one surface of the primary optic 602 to be a deformable surface 610 that is able to deform in response to an ocular force.
- the resulting deformation may produce a change in the radius of curvature or of a conic constant of at least one surface of the primary optic 602 .
- the thickness of the optic 602 is generally changed as it deforms. Deformation of the optic 602 generally results in a change in the optic properties of the optic 602 , for example, a change in the optical power or aberrations produced by the optic 602 .
- the primary optic 602 is generally configured to produce an add power that modifies the primary optical power and/or the combined optical power by at least about 1 Diopter, preferably by at least 2 Diopters, and more preferably by at least 3 Diopters.
- the add power is a change in optical power that allows the eye to focus on objects that are at distances from about 30 cm to about 2 meters in addition to distant objects located at distances that are greater than 2 meters.
- the accommodative capability or add power provided by deformation of the surface 610 may be supplemented by axial motion or travel of the primary optic 602 along the optical axis 608 in response to the ocular force, as discussed in greater detail above.
- the term “ocular force” means any force produced by the eye of a subject that stresses, moves, or changes the shape of the natural lens of the eye or of at least a portion of an optic or intraocular lens that is placed in the eye of a subject.
- the ocular force acting on a lens may be produced, for example, by the state or configuration of the ciliary body (e.g., contracted or retracted), changes in the shape of the capsular bag of the eye, stretching or contraction of one or more zonules, vitreous pressure changes, and/or movement of some part of the eye such as the ciliary body, zonules, or capsular bag, either alone or in combination.
- a “basic prescription” means an amount of optical power of a lens or an optic that is able to provide normal or functional vision to a subject when viewing objects located at a specified distances from the subject.
- a “basic prescription for distant vision” is an amount of optical power for a lens or an optic that will allow a subject to resolve distant objects with a predetermined amount of visual acuity (e.g., to resolve the letters on a Snellen eye chart disposed at a distance of 20 feet from the subject with a visual acuity of at least 20/20, 20/30, or 20/40, based on the standard Snellen test for visual acuity).
- a basic prescription e.g., for distant, intermediate, or near vision
- a lens or an optic that allows a subject to resolve objects at a specified distance with a predetermined degree of visual acuity (e.g., to resolve objects 20 feet from a subject with a visual acuity of at least about 20/40, more preferably of at least 20/30, and even more preferably of at least 20/20).
- the phrase “substantially provide a basic prescription” means to provide an ophthalmic device, intraocular lens, or other internal optic that may be combined with an external lens, such as a spectacle lens or a contact lens, to allow a subject to resolve objects with a predetermined amount of visual acuity.
- the external lens typically has an optical power that is within a range of ⁇ 4 Diopters, preferably within a range of ⁇ 3 Diopters, and more preferably within a range of ⁇ 1 Diopter.
- the primary optic 602 may be deformed by using a rigid optic 611 that is configured to deform the primary optic 602 in a predetermined manner, so as to produce accommodation or some other desired effect (e.g., changing the aberrations of the primary optic 602 and/or the wavefront that is directed to the retina of the eye 607 ).
- the optics 602 , 611 are configured so that the deformable surface 610 is deformed when the optics 602 , 611 are pressed together, as illustrated by comparing FIG. 10 with FIG. 11 .
- the movement assembly 620 is structured to cooperate with the eye to effect accommodating axial movement of the primary optic 602 and accommodating deformation of the primary optic 602 in response to an ocular force produced by the eye 607 .
- the rigid optic 611 may be configured as a meniscus lens having no or substantially no optical power.
- the rigid optic 611 may be a meniscus or some other type of lens having either a positive or negative optical power and/or may have other optical properties such as the ability to compensate for optical aberrations and/or form a multifocal image on the retina when the eye 607 in an accommodative or disaccommodative state.
- the rigid optic 611 has an optical power (and/or some other optical characteristic) and either replaces or supplements the supplemental optic 604 .
- the structure and function of the movement assemblies similar to that movement assembly 620 in the illustrated embodiment are described in greater detail in U.S. Pat. No. 6,443,985, and U.S. Patent Application Publication Numbers 2004/082994 and 2004/0111153, which are all herein incorporated by reference.
- One advantage of embodiments of the current invention is an increased ability to achieve a predetermined optical power or refractive outcome (e.g., the ability to resolve both distant objects and object at a reading distance of about 30 cm with a resolution of 20/30 or better).
- a predetermined optical power or refractive outcome e.g., the ability to resolve both distant objects and object at a reading distance of about 30 cm with a resolution of 20/30 or better.
- the basic prescription for an aphakic eye and/or amount of accommodative capability of the eye may not be precisely known, since the precise contribution of the natural lens alone may not be precisely determinate.
- the deformable primary optic 602 is implanted into the eye 607 to substantially provide the basic prescription for both distant and near vision (for example within ⁇ 2 Diopter).
- the patient may then be refracted in the usual manner to obtain a more accurately determination of the basic prescription for both distant and near vision.
- the optical power of the supplemental optic 604 may then be selected to provide the predetermined optical
- a primary optic 602 may be produced with a particular geometry and/or base optical power that has an optimized or predetermined optical performance over a range of add powers as compared to other geometries and/or base optical powers.
- This optimized primary optic 602 may be used in a variety of patients having different basic prescriptions to provide the same quality of accommodative performance for each.
- a different supplemental optic 604 with a different supplemental power for each the supplemental optic 604 being selected in each case to provide the correct total power when used in combination with the primary optic 602 .
- the supplemental optic 604 is a corrector optic that is selected to provide a predetermined refractive outcome in terms of optical performance or image quality of the eye and/or the ophthalmic device 600 .
- the supplemental optic 604 may have no or substantially no optical power or may have an optical power that is combined with the optical power of the primary optic 602 to provide near vision, distant vision, or intermediate vision.
- the supplemental optic 604 enhances optical performance or image quality by correcting or reducing an aberration such as a chromatic aberration or a monochromatic aberration of the eye and/or ophthalmic device 600 .
- one or both of the surfaces 605 , 606 of the supplemental 604 may be aspheric in form in order to reduce or compensate for a spherical aberration of the eye or ophthalmic device 600 .
- at least one the surfaces 605 , 606 be a monofocal or multifocal diffractive phase plate in order to reduce or compensate for a chormatic aberration of the eye or ophthalmic device 600 .
- the supplemental optic 604 may be configured to favorably modify the aberrations when the primary optic 602 is in an accommodative and/or disaccommodative state.
- the supplemental optic 604 is a corrector optic that is configured increase the depth of focus of the eye, for example, by changing the optical power or focal length of the supplemental optic 604 as a function of distance from the optical axis thereof.
- the supplemental optic 604 is configured to produce two or more simultaneous foci (e.g., a bifocal or multifocal lens).
- at least one of the surfaces 605 , 606 of the supplemental optic 604 may comprise a diffractive phase plate that produces two or more diffraction orders.
- at least one of the surfaces 605 , 606 may be configured to have an aspheric surface in which the radius of curvature varies with distance from the optical axis 608 .
- the primary optic 602 may be placed within a capsular bag 612 , as illustrated in FIGS. 10 and 11 , so that the ophthalmic device 600 is responsive to ocular forces produced by ciliary muscle 614 and/or zonules 618 .
- the primary optic 602 may be implanted elsewhere within the eye 607 .
- the anterior and posterior capsules of the capsular bag 612 may be allowed to attach to one another and the ophthalmic device 600 implanted within the sulcus of the eye 607 so that the primary optic 602 is disposed in front of the capsular bag 612 .
- the primary optic 602 has an optical power of at least about 10 Diopters, at least 20 Diopters, or at least 30 Diopters.
- the primary optic 602 has a negative optical power, for example less than ⁇ 5 Diopters, less than ⁇ 10 Diopters, or less than ⁇ 20 Diopters. In yet other embodiments, the primary optic 602 has an optical power within the range of ⁇ 30 to +40 Diopters, ⁇ 20 to +30 Diopters, or ⁇ 10 to +20 Diopters.
- a patient has a basic prescription for distant vision that is expressed in terms of an optical power P distant .
- the difference between the optical power P distant and the base optical power P base of the primary optic 602 may be calculated and based on the ability of a surgeon or other practitioner to estimate the required basic prescription for distant vision, the primary optic 602 alone may be sufficient to restore both the distant and/or near vision of a patient to a degree that allows normal vision to be provided at least by the use of an external lens.
- the surgeon or practitioner is able to select the base optical power P base to be within ⁇ 4 Diopters of the basic prescription (e.g., abs (P distant ⁇ P base ) ⁇ 4 Diopters), preferably within ⁇ 2 Diopter of the basic prescription, more preferably within +1 Diopter of the basic prescription.
- the base optical power P base is within a range of zero to ⁇ 4 Diopters of the basic prescription for distant vision, preferably within a range of zero to ⁇ 2 Diopters, more preferably within a range of zero to ⁇ 1 Diopters.
- the primary optic 602 is able to provide normal vision over at least some distances. For example, if (P distant ⁇ P base ) is equal to ⁇ 3 Diopters after implantation of the primary optic 602 , the patient would have blurred distant vision, but a high degree of visual acuity at normal reading distances without the need for additional internal lenses (e.g. the supplemental optic 604 ) and/or external lenses (e.g., spectacles or contact lenses).
- additional internal lenses e.g. the supplemental optic 604
- external lenses e.g., spectacles or contact lenses
- the optical power P supplemental of the supplemental optic 604 is selected so that the combined optical power P combined is equal to or approximately equal to the basic prescription for distant vision (e.g., so that (P distant ⁇ P combined ) is approximately equal to zero).
- the supplemental optic 604 may be configured to be implanted together with the primary optic 602 or separately therefrom. In some embodiments, the supplemental optic 604 is only optionally implanted into the eye 607 when the actual vision provided by the primary optic 602 differs by a predetermined amount from an expected refractive outcome and/or the prescription of the patient changes by predetermined amount over time after initial implantation of the primary optic 602 and/or supplemental optic 604 .
- the supplemental optic 604 may be disposed in front of the iris or in the anterior chamber of the eye 607 , as illustrated for example in FIGS. 10 and 11 .
- the supplemental optic 604 may be disposed within the vicinity of the sulcus of the eye 607 , together with the primary optic 602 within capsular bag 612 , or slightly protruding from the capsular bag 612 .
- the supplemental optic 604 may be disposed within a cornea 619 of the eye as a corneal implant.
- the supplemental optic 604 may be a corneal implant disposed configured to be disposed within the cornea 619 or a surface profile disposed on or within the cornea 619 , the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure).
- the primary and supplemental optics 602 , 604 may be configured and disposed within the eye 607 so as to maintain a separation therebetween that is greater than a predetermined minimum, for example 200 micrometer, 500 micrometers, or about 1 millimeter.
- the primary and supplemental optics 602 , 604 may be configured and disposed within the eye 607 so as to press against one another while the eye 607 is in an accommodative and/or disaccommodative state and/or between an accommodative and a disaccommodative state.
- At least one surface of the primary optic 602 is configured to deform in response to an ocular force so as to modify the optical power of at least one of (1) the primary optic 602 , (2) the combined optical power of the optics 602 , 604 , and/or (3) the total or effective optical power of the entire eye 607 .
- the deformation may be the result of change in the radius of curvature as the primary optic 602 changes from an accommodative state and disaccommodative state, which results in a change in the optical power or focal length of the primary optic 602 .
- At least one surface of the primary optic 602 may change from a spherical profile to an aspheric profile or from a more spherical profile to a less spherical profile as the primary optic 602 changes from an accommodative state and disaccommodative state, or visa versa, wherein the profile change produces a change in optical power or in some other optical characteristic of the primary optic 602 .
- the primary optic 602 may change from a monofocal lens to a multifocal lens (either refractive or diffractive) as the primary optic 602 changes from an accommodative state and disaccommodative state, or visa versa.
- the primary optic 602 may be a multifocal lens, wherein the optical power or some other optical characteristic of the zones changes as the primary optic 602 changes between accommodative state and disaccommodative states.
- the primary optic 602 has a center thickness t i along the optical axis 608 when in a substantially unstressed state and a center thickness t f in the response to or in the absence of an ocular force.
- the primary optic 602 may be adapted to change the center thickness by a factor of at least 1.1 (e.g., the quotient t f /t i is at least 1.1), typically when the ocular force is in the range of about 1 to 10 grams, preferably in the range of about 5 to 10 grams.
- the primary optic 602 is adapted to change the center thickness by a factor of at least 1.05 or at least 1.2 or more.
- the primary optic 602 is adapted to change the center thickness by a factor of at least 1.05, 1.1, or 1.2 when the ocular force is in the range of about 1 to 5 gram or about 1 to 3 grams.
- the primary optic 602 has a center thickness along the optical axis 608 when the primary optic 602 is in a substantially unstressed state, the deformable optic adapted to change the center thickness by at least about 50 micrometers, preferably at least 100 micrometers, when the ocular force is in the range of about 1 to 9 grams, in the range of about 6 to 9 grams, or in the range of about 1 to 3 grams.
- the modification in optical power as the primary optic 602 deforms is preferably at least 1 Diopter, more preferably at least 2 Diopters or 3 Diopters, and even more preferably at least 2 to 4 Diopters or 3 to 5 Diopters.
- the amount of change in optical power of primary optic 602 is generally an effective Diopter change in the optical power, for example, from a principal plane of the primary optic 602 (e.g., somewhere between the anterior and posterior surfaces of primary optic 602 ). In general, and as illustrated in FIGS.
- the Diopter change may be a positive change as the ciliary muscle 614 contracts and the zonules 618 relax; however, other directions and/or types of Diopter change are allowable (e.g., multifocal and/or aberration changes).
- the ophthalmic device 600 comprises a movement assembly 620 that is operably coupled to the primary optic 602 and a fixation member 622 that is operably coupled to the supplemental optic 604 .
- the supplemental optic 604 may be coupled to the movement assembly 620 or comprise its own, separate movement assembly.
- the movement assembly 620 comprises an anterior portion 624 that engages the anterior capsule of the capsular bag 612 and a posterior portion 628 that engages the posterior capsule of the capsular bag 612 .
- the anterior and posterior portions 624 , 628 together form an enclosure that fills or substantially fills the capsular bag 612 .
- the movement assembly 620 may further comprise a plurality of arms 630 that are configured to pivot, rotate, bend and/or otherwise deform in response to deformation of the movement assembly 620 , whereby the primary optic 602 may be moved and/or deformed to provide accommodation.
- the anterior and posterior portions 624 , 628 are generally made of a resilient material (e.g., a silicone or acrylic material) that deforms in response to an ocular force in such a way that the movement assembly 620 conforms and remains in contact with the capsular bag 612 during accommodative movement thereof.
- the primary optic 602 may be configured to have a posterior vault rather than the anterior vault illustrated in FIGS. 10 and 11 , in which case the deformable surface 610 is pressed against the posterior capsule of the capsular bag 612 when the ciliary muscle 614 contracts and the shape of the capsular bag 612 changes.
- the posteriorly vaulted primary IOL 563 is made of a material that is sufficiently soft to deform in response to ocular forces and the compensating IOL 561 is configured as a supplemental optic.
- Other examples of devices and means for producing a predetermined amount of accommodation in response to an ocular force may be found, for example, in U.S. patent application Ser. No. 11/241,586, which is herein incorporated by reference.
- a method 700 of providing accommodative vision comprises an operational block 702 , making a first estimate of a basic prescription of a subject.
- the method 700 also comprises an operational block 704 , inserting the primary optic 602 into the eye 607 of the subject.
- the method 700 further comprises an operational block 706 , which includes making a second estimate of the basic prescription of the subject based on the presence of the primary optic 602 .
- the method additionally comprises an operational block 708 , implanting the supplemental optic 604 into the eye 607 .
- the surgeon make a first estimate of the basic prescription of the patient by, for example, measuring physical characteristic of the eye such as the axial length (AL) and the anterior chamber depth (ACD). Other dimensional parameters may also be measured including, but are not limited to, the corneal radius (CR), the corneal power (K), and crystalline lens thickness (LT).
- the first estimate may also include other parameters of the eye such as the refractive indices and/or estimated refractive indices of the various portions of the eye.
- the estimate may additionally or alternatively include performing one or more interactive vision tests with the subject, for example using the standard Snellen test for visual acuity.
- the first estimate is determined while the natural lens or a previously implanted intraocular lens is still in the eye. In some embodiments, the first estimate may be made after removal of the natural lens and/or explanting a previously implanted intraocular lens.
- the estimates of the basic prescription are made using ophthalmic instruments designed to measure physical properties of the eye or wavefront aberrations produced by the eye, for example using biometry or keratometry.
- Corneal surface measurements according to well-known topographical measurement methods may be used that express surface irregularities of the cornea. Corneal measurements for this purpose can be performed by the ORBSCAN.RTM. videokeratograph available from Orbtech or by corneal topography methods, such as EyeSys.RTM available from Premier Laser Systems.
- the corneal measurements may also include the measurement of the corneal refractive power.
- wavefront sensors such as the Hartmann-Shack sensor (J. Opt. Soc. Am., 1994, Vol. 11(7), pp. 1949-57) may also be used to determine aberrations of the eye.
- the wavefront sensor may be used in combination with topographic sensors to determine other physical characteristics of the eye such as its length.
- the surgeon implants the primary optic 602 into the eye 607 .
- the primary optic 602 is selected to have a base optical power P base that substantially provides the basic prescription and is within at least ⁇ 4 Diopters of the basic prescription. Since the primary optic 602 substantially provides a basic prescription and in addition has the ability to provide accommodation, the primary optic 602 advantageously allows a surgeon to use a single implanted optic to provide a patient both distant and near vision. In some cases, satisfactory distant vision and near vision may be restored using only the primary optic 602 , without the need of implanting the supplemental optic 604 or using other external lenses.
- the basic prescription is provided only for certain distances or the vision provided is within an acceptable range to allow a more accurate estimate of a patient's prescription for both near and distant vision.
- both distant and near vision may be restored using a single prescription spectacle or contact lens, since the primary optic 602 provides accommodative ability.
- the supplemental optic 604 may be implanted to restore full vision of both distant and near objects.
- the primary optic 602 is able to substantially provides the basic prescription, a more accurate estimate of the aberrations of eye 607 may be made and subsequently corrected or compensated for using either an external optic and/or the supplemental optic 604 .
- the surgeon may make the second estimate of the basic prescription either at the time of the surgery or at a time shortly after the implantation of the primary ophthalmic device 600 .
- the second estimate may be made at a later time by the surgeon or by another practitioner, such as an optometrist, after the subject has more fully recovered from the surgical procedure.
- the time between the implantation of the primary optic 602 and the second estimate is an extended period of time in order to allow the eye to recover from the surgical procedure.
- the period of time may be one week, one month, or even several months (from at least about three months to at least about 6 months).
- the basic prescription may change some time after implantation of the primary optic 602 (perhaps for causes unrelated to the surgical procedure), thereby necessitating a second estimate and correction of the subject's vision.
- the supplemental optic 604 may be made relatively thin and is disposed in front of the primary optic 602 and nearer to the front of the eye 607 (e.g., in the anterior chamber in the illustrated embodiment).
- the primary optic 602 and/or the supplemental optic 604 belong to a system or set of intraocular lenses.
- the set of optics comprises a single primary optic 602 and a set or plurality S 1 of supplemental optics 604 .
- the single primary optic 602 may configured to provide an approximate correction for predetermined population, for example a population of patients with eyes having a particular range of axial lengths or type or shape of cornea, while the supplemental optic 604 is selected from the set S 1 of supplemental optics 604 to provide a more precise correction for a particular individual within the population.
- the primary optic 602 may have a base optical power selected to be at or near the average basic prescription for a particular population.
- the primary optic 602 may be configured to provide a predetermined optical quality over a range of expected amounts of a particular optical aberration for a particular population.
- Each of the supplemental optics 604 from the set S 1 of supplemental optics 604 may be configured to vary from one another in optical power by a predetermined amount.
- the supplemental optics 604 may be configured to vary by 1 ⁇ 2 Diopter, 1 ⁇ 4 Diopter, or less than 1 ⁇ 4 Diopters from one another.
- the primary optic 602 is implanted to provide and approximate correction of vision for the patient and a predetermined optical performance over range of accommodation add powers.
- the primary optic 602 is selected from plurality or set P 2 of primary optics 602 and the supplemental optic 604 is selected from a set or plurality S 2 of supplemental optics 604 . Since there is more one primary optic 602 for providing an approximate correction of the eyes in a given population, the number of optics in the set S 2 of supplemental optics 604 may be relatively small, for example as compared to the number of optics in the set S 1 previously discussed. Alternatively, the optics in the sets P 2 of primary optics 602 and in the set S 2 of supplemental optics 604 may be configured to provide visual correction for populations having variations in basic prescription that are too large to be covered using only a single primary optic 602 , as in the previous embodiment.
- the ophthalmic device 600 comprises a corrector optic 604 c configured to correct the optical power of the primary optic 602 , wherein the primary optic 602 may be configured to have a base optical power that is selected to provide a patient's basic prescription for at least one of distant vision, intermediate vision, or near vision.
- the corrector optic 604 c may be configured to correct a monochromatic aberration and/or a chromatic aberration of, for example, the primary optic 602 , the cornea 619 , and/or an overall aberration of the eye 607 .
- the corrector optic 604 c may have an overall positive or negative optical power, for example, within a range of about ⁇ 4 Diopters to +4 Diopters or in a range of ⁇ 2 Diopters to +2 Diopters. Also, the corrector optic 604 c may be a multifocal lens and/or provide cylinder correction. Alternatively, the corrector optic 604 c may have no or substantially no overall optical power and be used primary to correct an aberration of primary optic 602 or the eye 607 . When the corrector optic 604 c has no or substantially no optical power, the primary optic 602 generally has a base optical power that provides the patient's basic prescription. In some embodiments, the basic prescription will be the basic prescription for distant vision; however, the basic prescription may alternatively the basic prescription for intermediate or near vision.
- the corrector optic 604 c may be disposed in the sulcus, as illustrated in FIG. 11 .
- the corrector optic 604 c may be disposed in the anterior chamber, similar to the location of the supplemental optic 604 in FIGS. 9 and 10 .
- the corrector optic 604 c may be a corneal implant configured to be disposed within the cornea 619 or a surface profile disposed on or within the cornea 619 , the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure).
- the corrector optic 604 c is the rigid optic 611 configured to deform the primary optic 602 in a predetermined manner. In such embodiments, the optics 602 , 604 c are configured such that the deformable surface 610 of the primary optic 602 is deformed when the optics 602 , 604 c are pressed together.
- the corrector optic 604 c may be used to correct monochromatic and/or chromatic aberrations of the ophthalmic device 600 , the eye 607 of an individual, or a population of eyes.
- the corrector optic 604 c may be a purely refractive optical element or may additionally or alternatively comprise a diffractive element, for example, as discussed in U.S. Pat. Nos. 4,642,112, 4,881,805, and 5,144,483, which are herein incorporated by reference. Diffractive elements may be especially useful for correcting chromatic aberrations and may be configured to provide either monofocal or multifocal lens.
- the corrector optic 604 c When the corrector optic 604 c is purely refractive, it may be configured to correct a chromatic aberration by combining a plurality of optical elements that are each made of a different material having different optical characteristics (e.g., different refractive indices and/or Abbe numbers). Monochromatic aberrations that may be corrected by the corrector optic 604 c include, but are not limited to, astigmatic, spherical, and/or comatic. Correction of such aberrations is discussed in greater detail, for example, in U.S. Pat. Nos. 5,777,719, 6,609,793, and 6,830,332, which are herein incorporated by reference.
- the primary optic 602 is a corrector optic that may be used to correct or compensate for an optical aberration of the eye 607 and/or the supplemental optic 604 .
- the primary optic 602 and the supplemental optic 604 together correct or compensate for an optical aberration of at least a portion of the eye 607 .
- the primary optic 602 may be configured to correct astigmatism produced by the cornea 619 , while the supplemental optic 604 is selected to correct a spherical aberration of the cornea 619 .
- the primary optic 602 may be configured to correct a spherical aberration of the cornea 619 based on a preliminary estimate before the primary optic 602 is implanted into the eye 607 .
- the supplemental optic 604 may then be select to have a spherical aberration that compensates for any remaining spherical aberrations resulting from implantation of the primary optic 602 .
- the corrector optic 604 c is selected from a plurality or set S 3 of corrector optics 604 c, wherein each of the corrector optics 604 c from the set S 3 has a predetermined value of an optical characteristic that is different from the value of that optical characteristic for the other corrector optics 604 c within the set S 3 .
- At least one of the corrector optics 604 c in the set S 3 is configured to provide, in combination with the primary optic 602 , the basic prescription of the patient for at least one of distant vision, near vision, or intermediate vision.
Abstract
Description
- This application is a Continuation-in-Part Application of U.S. patent application Ser. No. 10/234,801, filed Sep. 4, 2002, which is a Continuation-in-Part Application of U.S. patent application Ser. No. 09/390,380, filed Sep. 3, 1999, which claims the benefit of U.S. Provisional Application No. 60/132,085 filed Apr. 30, 1999. The disclosures of both the provisional application and the non-provisional application are incorporated in their entirety by reference herein.
- 1. Field of the Invention
- The present invention relates generally to devices and methods for correcting vision and more particularly to ophthalmic device combinations for providing accommodative vision.
- 2. Description of the Related Art
- The human eye includes an anterior chamber between the cornea and iris, a posterior chamber including a capsular bag containing a crystalline lens, a ciliary muscle, a vitreous chamber behind the lens containing the vitreous humor, and a retina at the rear of this chamber. The human eye has a natural accommodation ability. The contraction and relaxation of the ciliary muscle provides the eye with near, intermediate and distant vision. This ciliary muscle action shapes the natural crystalline lens to the appropriate optical configuration for focusing light rays entering the eye on the retina.
- After the natural crystalline lens is removed, for example, because of cataract or other condition, a conventional, monofocal IOL can be placed in the postelior chamber. Such a conventional IOL has very limited, if any, accommodating ability. However, the wearer of such an IOL continues to require the ability to view both near and far (distant) objects. Corrective spectacles may be employed as a useful solution. Multifocal IOLs without accommodating movement have also been used to provide near/far vision correction.
- Attempts have been made to provide IOLs with accommodating movement along the optical axis of the eye as an alternative to shape changing. Examples of such attempts are set forth in Levy U.S. Pat. No. 4,409,691, U.S. Pat. Nos. 5,674,282 and 5,496,366 to Cumming, U.S. Pat. No. 6,176,878 to Gwon et al, U.S. Pat. No. 6,231,603 to Lang et al, and U.S. Pat. No. 6,406,494 to Laguette et al. The disclosure of each of these patents is incorporated herein by reference.
- One problem that exists with such IOLs is that they often cannot move sufficiently to obtain the desired accommodation. The degree of accommodation has been closely related to the lens prescription of the individual patient. In addition, the presence of such lenses can result in cell growth from the capsular bag onto the optics of such lenses. Such cell growth, often referred to as posterior capsule opacification (PCO), can interfere with the clarity of the optic to the detriment of the lens wearer's vision.
- Another problem that can occur is that of providing an intraocular lens that provides a predetermined amount of accommodative power for a wide variety of eyes and with a relatively low amount of aberrations for both near and distant vision. This problem may arise because mechanical stresses used to change the focal length of a lens generally give rise to optical aberrations that reduce visual acuity of the eye. A related problem is that of determining a precise prescription for the aphakic eye prior to the surgical procedure for replacing the natural lens with an accommodative intraocular lens. This may result in implantation of an intraocular lens that is either too strong or too weak for the patient, or that does not produce enough accommodation to provide both near and distant vision. A similar problem may occur when the correct prescription is initially provided, but the patient's prescription changes over time.
- It would be advantageous to provide IOLs adapted for accommodating movement and/or deformation, which can preferably achieve an acceptable amount of accommodation and/or a reduced risk of PCO. It would also be advantageous to provide accommodating intraocular lenses or systems of ophthalmic devices that accurately provide a patient's prescription for distant and/or near vision in a way that produces little or no optical aberrations.
- New combinations of ophthalmic devices such as intraocular lens combinations (ILCs) have been disclosed. Embodiments of the present invention provide distance, near and/or intermediate vision by axially moving and/or deforming one or more optical elements, for example, by deforming at least one optical surface (e.g., changing a radius of curvature or conic constant of the surface) and/or changing the thickness of the optic. The present combinations may be used to enhance the degree of accommodation achieved in spite of the movement and space limitations within the eye and to produce near and/or distant vision that is relatively low in optical aberrations. One advantage of the present combinations is the ability to standardize the prescription or optical power of the accommodating lens or optic of the combination. Thus, the required amount of movement and/or deformation in the eye to achieve accommodation can be substantially the same for all patients or for a particular class or category of patients. This greatly facilitates the design of the moving or deforming of the accommodating lens or optic. Further, with at least certain of the present combinations, improved inhibition of PCO is obtained. The present combinations may be designed to be relatively straightforward in construction, implanted or inserted into the eye using systems and procedures which are well known in the art, and be made to function effectively with little or no additional treatments or medications being required. In addition to changing the optical power of the eye, combinations of ophthalmic devices according to the present invention may also include a corrector lens or optic that is used in combination with an accommodating lens, wherein the corrector lens or optic is configured to correct monochromatic and/or a chromatic aberrations of a primary intraocular lens and/or of at least a portion of the ocular imaging system.
- In one broad aspect of the present invention, intraocular lens combinations (ILCs) comprise a first optic body, second optic body and a movement assembly. The first optic body has a negative or plano optical power and is adapted to be placed in a substantially fixed position in a mammalian eye. In those cases where the first optic body has a negative optical power, it is also called the compensating optic body. The second optic body, also called the primary optic body, has a higher optical power than the first optic body. The movement assembly is coupled to the second optic body and is adapted to cooperate with the eye, for example, the zonules, ciliary muscle and capsular bag of the eye, to effect accommodating movement and/or accommodating deformation of the second optic body in the eye, for example, in response to one or more ocular forces or naturally occurring actions of the eye.
- Advantageously, the second optic body has a high plus optical power to reduce the amount of movement, for example, axial movement, in the eye needed to provide accommodation for intermediate and near vision. The negative or minus optical power of the first optic body compensates for the excess plus or positive optical power in the first optic body. The use of such a compensating lens, that is the first optic body having a negative optical power, can allow for standardization of the optical power correction in the second optic body. In other words, the optical power of the second optic body, that is the primary or movable optic body, can be approximately equal from optic body to optic body, while the optical power of the first optic body, that is the compensating or fixed optic body, is adjusted from optic body to optic body to meet the specific vision correction needs (prescription) of each individual patient. Consequently, the required amount of movement of the second optic body in the eye can be approximately the same for all patients.
- The present ILCs provide accommodation, preferably an acceptable degree of accommodation, in spite of movement and space limitations in the eye. For example, the maximum theoretical amount of axial movement for a simple disc lens having an overall diameter of 11 millimeters (mm) and an optic diameter of 5 mm that undergoes 1 mm of compression in its diameter is about 1.65 mm. The amount of axial movement required for a plus 15 diopter optic to provide 2.5 diopters of additional power in the spectacle plane is about 2.6 mm. However, a plus 30 diopter optic requires only 1.2 mm of axial movement to provide 2.5 diopters of additional power in the spectacle plane. Thus, by increasing the plus power of the second optic, which is adapted for accommodating movement, a reduced amount of movement is needed to achieve higher or enhanced degrees of accommodation. The first or fixed optic may have a minus power to compensate for the excess plus power in the second optic.
- The present ILCs may include first and second optics with optical powers which provide a net plus optical power. To illustrate, assume that the patient requires a plus 15 diopter correction. The first optic body is provided with a minus 15 diopter optical power and the second optic body with a plus 30 diopter optical power. The net optical power of this ILC is approximately the sum of minus 15 diopters and plus 30 diopters or plus 15 diopters, the desired prescription for the patient in question. The powers of the first and second optics are only approximately additive since the net power of the combination also depends on other factors including, but not limited to, the separation of the two optics, the magnitude of the power of each individual optic body and its location in the eye and the like factors. Also, by adjusting the optical power of the first optic body, the net optical power of the ILC can be adjusted or controlled even though the optical power of the second optic body is standardized or remains the same, for example, at a plus 30 diopter optical power. By standardizing the optical power of the second optic body, the amount of movement in the eye required to obtain a given level of accommodation is substantially the same, and preferably well within the space limitations in the eye, from patient to patient.
- In one very useful embodiment, the movement assembly comprises a member including a proximal end region coupled to the second optic body and a distal end region extending away from the second optic body and adapted to contact a capsular bag of the eye. Such movement assembly may completely circumscribe the second optic body or may be such as to only partially circumscribe the second optic body.
- The second optic body preferably is adapted to be positioned in the capsular bag of the eye.
- The first optic body may be coupled to a fixation member, or a plurality of fixation members, adapted to assist in fixating the first optic body in the eye. Each fixation member may have a distal end portion extending away from the first optic body. In one embodiment, the distal end portion of the fixation member is adapted to be located in the capsular bag of the eye. Alternately, the distal end portion of the fixation member may be located in contact with a sulcus of the eye. As a further alternate, the distal end portion of the fixation member may be adapted to be located in an anterior chamber of the eye.
- The first optic body may be located posterior in the eye relative to the second optic body or anterior in the eye relative to the second optic body. In a useful embodiment, the first optic body is adapted to be positioned in contact with the posterior wall of the capsular bag of the eye. This positioning of the first optic body provides for effective compensation of the plus or positive vision correction power of the second optic body. In addition, by having the first optic body in contact with the posterior wall of the capsular bag, cell growth from the capsular bag onto the ILC, and in particular onto the first and second optics of the ILC, is reduced. This, in turn, reduces the risk of or inhibits posterior capsule opacification (PCO).
- In one embodiment, the fixation member or members and the movement assembly are secured together, preferably permanently secured together. Thus, when inserting the ILC into the eye, a single combined structure can be inserted. This reduces the need to position the first and second optics relative to each other. Put another way, this feature allows the surgeon to very effectively and conveniently position the ILC in the eye with reduced surgical trauma to the patient.
- The fixation member and movement assembly may be secured, for example, fused, together at the distal end portion of the fixation member and the distal end region of the movement assembly.
- In an alternate embodiment, there is no connection between the fixation member or members of the compensating lens and the movement assembly of the primary lens. That is, the compensating lens and primary lens are completely separate from and independent of one another, enabling them to be implanted consecutively, rather than simultaneously. This allows the lenses to be inserted through a smaller incision than would be possible with a combined structure. In the case of separate lenses, however, special care must be taken to axially align the two lenses in order to avoid decentration issues.
- In another broad aspect of the present invention, ILCs are provided which comprise a first optic body having a posterior surface adapted to be positioned in contact with a posterior wall of the capsular bag of the eye; a second optic body adapted to focus light toward a retina of the eye; and a movement assembly coupled to the second optic body and adapted to cooperate with the eye to effect accommodating movement of the second optic body in the eye. The first optic body has a substantially piano optical power or a negative optical power. These ILCs are particularly adapted to inhibit PCO.
- The first optic body of these combinations preferably is adapted to be placed in a substantially fixed position in the eye. The posterior surface of the first optic body advantageously is configured to substantially conform to a major portion, that is, at least about 50%, of the posterior wall of the capsular bag of the eye in which the combination is placed. More preferably, the posterior surface of the first optic body is configured to substantially conform to substantially the entire posterior wall of the capsular bag. Such configuration of the first optic body is very useful in inhibiting cell growth from the eye onto the first and second optics and in inhibiting PCO.
- In one embodiment, the first optic body, which contacts the posterior wall of the capsular, has a substantially plano optical power and the second optic body has a far vision correction power. In an alternate embodiment, the first optic body has a negative optical power and the second optic body has a positive optical power, so that the optical powers of the first and second optics provide a net plus optical power in the eye in which the combination is placed. In this latter embodiment, the second, or primary, optic body is preferably placed in the capsular bag, while the first, or compensating, optic body, may be placed in the bag, the sulcus or the anterior chamber, or attached to the iris.
- In a very useful embodiment, the first optic body includes an anterior surface and at least one projection extending anteriorly from this anterior surface, The at least one projection is positioned to limit the posterior movement of the second optic body in the eye. Thus, the movement of the second optic body is effectively controlled to substantially maintain the configuration of the combination and/or to substantially maintain an advantageous spacing between the first and second optics.
- The movement assembly may be structured and functions similarly to movement assembly of the previously described ILCS.
- The first optic body may have a fixation member or members coupled thereto. The fixation member or members are adapted to assist in fixating the first optic body in the eye, that is in contact with the posterior wall of the capsular bag of the eye. In one embodiment, the first optic body itself is configured and/or structured so that no fixation member or members are needed to maintain the first optic body in contact with the posterior wall of the capsular bag of the eye. The first optic body and the movement assembly of these ILCs may be secured together.
- In general, the first and second optics of the present ILCs may be made of any suitable materials. The first and second optics may be made of polymeric materials and, along with the movement assembly and any fixation member(s), are deformable for insertion through a small incision in the eye.
- The present movement assemblies are sufficiently flexible to facilitate movement of the second optic body in the eye upon being acted upon by the eye. In one very useful embodiment, the movement assembly includes a hinge assembly that may be adapted and positioned to facilitate the accommodating movement of the second optic body.
- In those embodiments in which the first optic body has a substantially piano optic body power, the second optic body preferably has a far vision correction power, more preferably such a power for infinity, in the unaccommodated state.
- In a further broad aspect of the present invention, methods for inserting an ILC in an eye are provided. Such methods comprise providing an ILC in accordance with the present invention, as described herein. The ILC is placed into the eye, for example, in the capsular bag of the eye or partly in the capsular bag of the eye, using equipment and techniques which are conventional and well known in the art. The ILC is placed in a rest position in the eye, for example, a position so that the eye, and in particular the ciliary muscle and zonules of the eye, effectively cooperate with the movement assembly to move the second optic body of the ILC anteriorly in the eye from the rest position to provide for positive accommodation. No treatments or medications, for example, to paralyze the ciliary muscle, to facilitate fibrosis or otherwise influence the position of the ILC in the eye, are required.
- In one embodiment, the primary and compensating lenses are connected by the fixation member or members and the movement assembly, and are thus simultaneously implanted in the eye. In another embodiment, the primary lens is implanted first and centered about the optical axis. The compensating lens is then inserted anteriorly of the primary lens and optically aligned with the primary lens. This latter embodiment may require a smaller incision than that required for the unitary combination of the former embodiment. In addition, this embodiment allows for refractive measurements to be made after the primary lens has been implanted, so that any new refractive errors that may have been introduced as a result of the surgery itself can be taken into account, and a more accurate prescription for the compensating lens can be obtained.
- Preferably, the first and second optics and the movement assembly are deformed prior to being placed into the eye. Once the ILC is placed in the eye, and after a normal period of recovery from the surgical procedure, the ILC, in combination with the eye, provides the mammal or human wearing the ILC with effective accommodation, preferably with reduced risk of PCO. In the unaccommodated state, the ILC preferably provides the mammal or human wearing the ILC with far vision correction.
- In certain embodiments, an accommodating ophthalmic device comprises a primary optic and supplemental optic. The primary optic is configured for placement in an eye of a subject or patient having a basic prescription (e.g., a basic prescription for distant vision or near vision) and has a base optical power that is selected to at least partially provide the basic prescription. In some embodiments, the base optical power is selected to be within 8 Diopters of the basic prescription, preferably within 4 Diopter of the basic prescription, and even more preferably within 2 Diopters of the basic prescription. The supplemental optic has an optical power that is selected to adjust or compensate for the base optical power and may be selected to have an optical power that is within a range of about −4 Diopters to +4 Diopters. The supplemental optic and the primary optic preferably have a combined optical power that is capable of providing the basic prescription of the patient to within 2 Diopters of the basic prescription, even more preferably within 1 Diopter of the basic prescription. In addition, at least one surface of the primary optic is configured to deform in response to an ocular force (e.g., contraction or relaxation of the ciliary muscle) so as to modify the combined optical power of the ophthalmic device or eye by at least I Diopter. The ophthalmic device may further comprise a movement assembly operably coupled to the primary optic that is structured to cooperate with the eye to effect accommodating deformation of the primary optic in response to an ocular force produced by the eye. The movement assembly may additionally or alternatively be configured to provide accommodating axial movement of the primary optic.
- The primary optic of the accommodating ophthalmic device may be selected in accordance to the structure of the eye into which the primary optic is to be placed. In some embodiments, the supplemental optic is selected to change or adjust the optical power provided by the primary optic. In other embodiments, the supplemental optic is a corrector optic that is selected to correct the primary optic or a portion of the eye and that has either no optical power or an optical power that is within a range of about −4 Diopters to +4 Diopters. The corrector optic may be configured to correct a monochromatic aberration and/or a chromatic aberration of the primary optic and/or at least a portion of the eye (e.g., the cornea of the eye). For example, the corrector optic may be used to correct or compensate for an astigmatic aberration, a spherical aberration, and/or a comatic aberration.
- The supplemental optic may be implanted together with the primary optic or separately from the primary optic (e.g., during a subsequent surgery from that in which the primary optic is implanted). The primary optic is preferably implanted within the capsular bag of the eye, but alternatively may be implanted outside the capsular bag, for example in the vicinity of the sulcus. The supplemental optic may also be implanted in the capsular bag in front of the primary optic; however, may alternatively be implanted anywhere in the anterior or posterior chambers of the eye. The primary and supplemental optic may be configured to maintain a separation between one another upon implantation within the eye or may be configured to contact one another in the eye. In some embodiments, the supplemental optic may be a corneal implant configured to be disposed within the cornea or a surface profile disposed on or within the cornea, the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure).
- In another aspect of the current invention, the supplemental optic is designed to provide a predetermined refractive outcome in terms of optical performance or image quality. In such embodiments, the supplemental optic may have an overall optical power that may be combined with the optical power of the primary optic to provide near vision, distant vision, or intermediate vision. Alternatively, the supplemental optic may have no or substantially no optical power. In either case, the supplemental optic is a corrector optic that is selected to correct an optical aberration, for example a spherical aberration of the eye and/or at least one surface of an optic of the ophthalmic device. In some embodiments, the supplemental optic is configured to favorably modify the aberrations when the primary optic is in an accommodative and/or disaccommodative state. In other embodiments, the supplemental optic is configured increase the depth of focus of the eye, for example, by changing the optical power or focal length of the supplemental optic as a function of distance from the optical axis thereof. In still other embodiments, the supplemental optic is configured to produce two or more simultaneous foci (e.g., a bifocal or multifocal lens).
- In certain embodiment, the primary optic, the supplemental optic, and/or the corrector optic are part of a system or set of intraocular lenses for insertion into an eye. For example, the set of intraocular lenses may comprise a plurality of supplemental optics, each supplemental optic having a value of an optical characteristic that is different from the other supplemental optics of the plurality, at least one of the supplemental optics configured to provide, in combination with the primary optic, the basic prescription of the patient. The different optical characteristic may be a different optical power and/or a different amount of an optical aberration or some other optical characteristic (e.g., a different first order diffraction efficiency of a multifocal phase plate).
- Any and all features described herein and combinations of such features are included within the scope of the present invention provided that the features of any such combination are not mutually inconsistent.
- Further aspects and advantages of the present invention are set forth in the following detailed description and claims, particularly when considered in conjunction with the accompanying drawings in which like parts bear like reference numerals.
- Embodiments of the present invention may be better understood from the following detailed description when read in conjunction with the accompanying drawings. Such embodiments, which are for illustrative purposes only, depict the novel and non-obvious aspects of the invention. The drawings include the following figures, with like numerals indicating like parts:
-
FIG. 1 is a front plan view of an ILC in accordance with the present invention. -
FIG. 2 is a cross-sectional view taken generally along line 2-2 ofFIG. 1 . -
FIG. 3 is a cross-sectional view of an additional ILC in accordance with the present invention. -
FIG. 4 is a fragmentary sectional view of an eye in which an alternate ILC in accordance with the present invention has been implanted. -
FIG. 5 is a fragmentary sectional view, similar toFIG. 4 , in which the compensating optic body of the ILC is implanted in the anterior chamber of the eye. -
FIG. 6 is a front plan view of an intraocular lens useful in an ILC in accordance with the present invention. -
FIG. 7 is a fragmentary sectional view, similar toFIGS. 4 and 5 , in which the compensating optic body of the ILC is implanted in the capsular bag of the eye. -
FIG. 8 is a front view of a primary lens according to another embodiment of invention having accommodative ability to provide both distant and near vision. -
FIG. 9 is a cross-sectional view taken generally along line 9-9 ofFIG. 8 . -
FIG. 10 is a cross-sectional view of an ophthalmic device according to an embodiment of the invention in an disaccommodative state, the device including the primary lens ofFIG. 9 and a supplemental or corrector optic disposed within the anterior chamber of the eye. -
FIG. 11 is a cross-sectional view of the ophthalmic device shown inFIG. 10 in an accommodative state. -
FIG. 12 is block diagram of a method of providing accommodative vision according to an embodiment of the invention. -
FIG. 13 is a cross-sectional view of an ophthalmic device according to an embodiment of the invention including a primary lens ofFIG. 9 and a corrector optic support by the sulcus of the eye. - Referring now to
FIGS. 1 and 2 , an ILC according to the present invention, shown generally at 10, includes a first optic oroptic body 12, a second optic oroptic body 14, a disctype fixation member 16 and a disctype movement assembly 18. As used herein, the term “optic” or “optic body” means an optical element that may be used alone or as part of an optical system to produce an image on the retina the eye of a subject. The terms “optic” and “optic body” are used somewhat interchangeable, with the term “optic” emphasizing more the optical characteristics of an optical element and “optic body” referring more to the use an optical element as part of an intraocular lens that may also include, for example, a base element, a movement assembly, or one or more haptics, fixation members, and/or movement members. An optic or optic body may have an optic power to converge or diverge incident light using the principles of refraction, diffraction, and/or reflection of light. Alternatively, the optic or optic body may have substantially no optical power and/or be used to at least partially correct or compensate for an optical aberration, for example, by varying the optical characteristics of the optical element over the surface (e.g., as a function of radius from the center of the optical element). In addition, the optic or optic body may combine both optical power and aberration correction characteristics into a single optical element. Examples of aberration correction are found in U.S. Pat. Nos. 6,338,559 and 6,948,818, which are herein incorporated by reference. - The first
optic body 12 has substantially piano optical power and is adapted to be held in a fixed position, for example, at least partially by thefixation member 16. When theILC 10 is positioned in a human eye, theposterior surface 20 of firstoptic body 12 is in contact with the inner posterior wall of the capsular bag of the eye. This positioning ofoptic body 12 is very effective in reducing or inhibiting endothelial cell growth from the capsular bag onto the firstoptic body 12. In effect, the positioning of the firstoptic body 12 against the posterior surface of the capsular bag inhibits or reduce the risk of PCO. - The second
optic body 14 includes a distance vision correction power. Themovement assembly 18 extends radially outwardly from secondoptic body 14 and fully circumscribes the secondoptic body 14.Movement assembly 18 has aproximal end region 22 which is coupled to the secondoptic body 14 at firstoptic body periphery 24.Movement assembly 18 extends radially outwardly to adistal end region 26 including aperipheral zone 28,Fixation member 16 includes adistal end portion 30 including aperipheral area 32. Themovement assembly 18 andfixation member 16 are fused together at theperipheral zone 28 andperipheral area 32. Thus, theentire ILC 10 is a single unitary structure. The firstoptic body 12 andfixation member 16 can be manufactured separately from secondoptic body 14 andmovement assembly 18 and, after such separate manufacture, the fixation member and movement assembly can be fused together. Alternately, theentire ILC 10 can be manufactured together. Also, if desired, the firstoptic body 12 andfixation member 16 can be inserted into the eye separately from the secondoptic body 14 andmovement assembly 18. Thus,ILC 10 can comprise a plurality of separate components. -
Movement assembly 18 extends outwardly from secondoptic body 14 sufficiently so that thedistal end region 26, and in particular theperipheral zone 28 of thedistal end region 28, is in contact with the inner peripheral wall of the posterior capsular bag when theILC 10 is implanted in the eye. - As best seen in
FIG. 2 , whenILC 10 is at rest, the secondoptic body 14 is positioned vaulted anteriorly relative to thedistal end region 26 ofmovement assembly 18. In other words, theanterior surface 34 of secondoptic body 14 is anterior of theanterior surface 36 ofmovement assembly 18 atdistal end region 26 and/or theposterior surface 38 of the secondoptic body 14 is anterior of a posterior surface 39 of the movement assembly at thedistal end region 26. - The first and
second optics optics second optics - As noted previously, first
optic body 12 has a substantially piano or zero optical power. Secondoptic body 14 is prescribed for the wearer ofILC 10 with a baseline or far (distance) diopter power for infinity. Thus, the wearer ofILC 10 is provided with the vision correction power of secondoptic body 14 with little or no contribution from the firstoptic body 12. - The
fixation member 16 andmovement assembly 18, as shown, are integral (unitary) with and circumscribe the first andsecond optics fixation member 16 and/ormovement assembly 18 can be mechanically or otherwise physically coupled to firstoptic body 12 and secondoptic body 14, respectively. Also, thefixation member 16 and/ormovement assembly 18 may only partially circumscribe first andsecond optics fixation member 16 andmovement assembly 18 may be constructed from the same or different biocompatible materials as first andsecond optics Movement assembly 18 has sufficient strength and rigidity to be effective to transfer the force from the ciliary muscle of the eye so that the secondoptic body 14 is movable axially in the eye to effect accommodation. -
Movement member 18 includes a region of reduced thickness 41 located at theproximal end region 22. This area of reduced thickness, which completely circumscribes the secondoptic body 14, acts as a hinge to provide additional flexibility to themovement member 18 to extenuate or amplify the accommodating movement of secondoptic body 14 in response to the action of the ciliary muscle and zonules. - The
fixation member 16 andmovement assembly 18 preferably are deformable, in much the same manner as first andsecond optics ILC 10 through a small incision into the eye. The material or materials of construction from whichfixation member 16 andmovement assembly 18 are made are chosen to provide such members with the desired mechanical properties, e.g., strength and/or deformability, to meet the needs of the particular application involved. - The
ILC 10 can be inserted into the capsular bag of a mammalian eye using conventional equipment and techniques, for example, after the natural crystalline lens of the eye is removed, such as by using a phacoemulsification technique. TheILC 10 may be rolled or folded prior to insertion into the eye, and is inserted through a small incision into the eye and is located in the capsular bag of the eye. - The
ILC 10 in the eye is located in a position in the capsular bag so that theposterior surface 20 of firstoptic body 12 is maintained in contact with the inner posterior wall of the capsular bag. As noted previously, positioning the firstoptic body 12 in contact with the posterior wall of the capsular bag reduces the risk of or inhibits cell growth from the capsular bag onto the firstoptic body 12 which, in turn, reduces or inhibits PCO. The ciliary muscle and zonules of the eye provide force sufficient to move axially secondoptic body 14 sufficiently to provide accommodation to the wearer ofILC 10. - The
ILC 10 should be sized to facilitate the movement of the secondoptic body 14 in response to the action of the ciliary muscle and zonules of the eye in which the ILC is placed. - If the
ILC 10 is too large, the ciliary muscle and zonules will be inhibited from effectively contracting/relaxing so that the amount of accommodating movement will be unduly restricted. Of course, if theILC 10 is too small, the secondoptic body 14 will be ineffective to focus light on the retina of the eye, may cause glare and/or the movement member may not cooperate with the eye to effect the desired amount of accommodating movement. If theILC 10 is to be included in an adult human eye, the first andsecond optics ILC 10 preferably has an overall maximum diameter, with themovement assembly 18 in the unflexed or rest state, in the range of about 8 mm to about 11 mm or about 12 mm. - The
present ILC 10 has the ability, in cooperation with the eye, to move the secondoptic body 14 both posteriorly and anteriorly in the eye, to provide for both distance focus and near focus, respectively. This movement ofILC 10 advantageously occurs in response to action of the ciliary muscle and zonules, which action is substantially similar to that which effects accommodation in an eye having a natural crystalline lens. Thus, the ciliary muscle and zonules require little, if any, retraining to function in accordance with the present invention. Themovement member 18, as described herein, preferably is effective to facilitate or even enhance or extenuate the axial movement of the secondoptic body 14 caused by the action of the ciliary muscle and zonules to provide increased degree of accommodation. -
FIG. 3 illustrates an additional ILC, shown generally at 110, in accordance with the present invention. Except as expressly described herein,ILC 110 is structured and functions similar toILC 10. Components ofILC 110 which correspond to components ofILC 10 are indicated by the same reference numeral increased by 100. - One primary difference between
ILC 110 andILC 10 relates to the substitution of aposterior lens structure 40 for the firstoptic body 12 andfixation member 16.Lens structure 40 includes aposterior face 42 which is configured to come in contact with and substantially conform to the inner posterior surface of the capsular bag of the eye in which theILC 110 is to be placed. Thus, thesurface 42 which extends around theperipheral area 44 and across thecenter region 46 of thelens structure 40 is adapted to come in contact with and substantially conform to the inner posterior wall of the capsular bag. Moreover, thelens structure 40 is adapted to remain in contact with this inner posterior wall of the capsular bag and to be fixed in the eye. This configuration has been found to be very effective in inhibiting cell growth from the eye onto theILC 110. Theanterior surface 48 oflens structure 40 is configured to provide the lens structure with a substantially plano or zero optical power. Secondoptic body 114 is prescribed for the wearer ofILC 110 with a baseline or distance or far (distance) dioptic power for infinity. Thus, the wearer ofILC 110 is provided with a vision correction power of secondoptic body 114 with little or no contribution from thelens structure 40. - Alternately, second
optic body 114 has a high plus power, for example, plus 30 diopters. Thelens structure 40, and in particular the region of the lens structure, defined by theanterior surface 48, which extends substantially across the entire field of vision of the wearer ofILC 110, has a minus vision correction power which is controlled to provide the correction prescription for use in the eye in which theILC 110 is placed. For example, if this eye requires a plus 15 diopter power, thelens structure 40 has a vision correction power of approximately minus 15 diopters so that the net vision correction power of the combination oflens structure 40 and secondoptic body 114, is plus 15 diopters. - The lens structure can be made from materials described previously with regard to first
optic body 12 andfixation member 16. - One additional feature of
lens structure 40 relates to theanteriorly extending projections 50 which extend from thebase element 52 oflens structure 40. The number of theseprojections 50 can range from 2 to about 6 or more. Alternately, a continuous annulus projecting anteriorly can be provided. The purpose of theprojections 50 or the continuous annulus is to limit the posterior movement of the secondoptic body 114 andmovement assembly 118. This limitation in the movement provides an additional degree of control of theILC 110, and prevent a collapse of theILC 110 and maintains an advantageous degree of separation between secondoptic body 114 andanterior surface 48 oflens structure 40. -
FIG. 4 illustrates the use of an alternate ILC in accordance with the present invention. This ILC, shown generally at 60 includes a compensating IOL 61 comprising a first, or compensating,optic body 62, and aprimary IOL 63 comprising a second, or primary,optic body 64 and a movement assembly 66. The compensatingoptic body 62 is coupled to afixation member 68 which includes adistal end portion 70 in contact with theperiphery 72 of thesulcus 73 ofeye 74.Fixation member 68 is a disk fixation member which completely circumscribes the compensatingoptic body 62. However, it should be noted that thedisc fixation member 68 can be replaced by two or more filament fixation members or plate fixation members or other types of fixation members, many of which are conventional and well known in the art. Movement assembly 66 is coupled to the primaryoptic body 64 and completely circumscribes the primary optic body. The primaryoptic body 64 is located in thecapsular bag 76 ofeye 74 and is vaulted anteriorly to some extent to enhance accommodating movement of the primary optic body. - The primary
optic body 64 has a plus power higher than the power required by the basic prescription of a presbyopic patient. For instance for a patient requiring plus 15 diopters of far vision correction, primaryoptic body 64 might have a corrective power of plus 30 diopters. The compensatingoptic body 62 is a negative or minus lens having a minus vision correction power which is controlled to provide the correct prescription for use ineye 74. For the patient described above, the compensatingoptic body 62 has a vision correction power of approximately minus 15 diopters so that the net vision correction power of the combination of compensatingoptic body 62 and primaryoptic body 64 equals the patient's basic prescription of plus 15 diopters. The compensatingoptic body 62,fixation member 68, primaryoptic body 64 and movement assembly 66 can be made from materials described previously with regard to the firstoptic body 12,fixation member 16, secondoptic body 14 andmovement assembly 18, respectively. - The compensating
optic body 62 is shown here as a meniscus style optic body; that is, the anterior surface of the optic body is convex and the posterior surface is concave. However, other negative diopter configurations could also be used, such as plano/concave or biconcave. In addition, one or both of the surfaces of the compensatingoptic body 62 could be multifocal or aspheric to allow for additional accommodation. - In the configuration shown in
FIG. 4 , thefixation member 68 is in contact with theperiphery 72 of thesulcus 73 of theeye 74. This is a relatively durable component of the eye and is effective to support thefixation member 68 in maintaining the compensatingoptic body 62 in a fixed position. - The movement assembly 66 cooperates with the
ciliary muscle 78 andzonules 80 ofeye 74 to move the secondoptic body 64 axially alongoptical axis 82 of the eye. The amount of axial movement achieved will vary from patient to patient depending on such parameters as capsular bag dimensions. The movement is preferably at least about 0.5 mm, and more preferably at least about 0.75 mm. In a very useful embodiment, the accommodation assembly should allow about 1 mm to about 1.2 mm of movement. For example, with a primaryoptic body 64 having a corrective power of plus 30 diopters, this amount of movement will be amplified to create an additional add power, or diopter shift, of about 1.75 to about 2.5, or possibly as high as 3.5 diopters. A diopter shift in this range is consistent with the near vision, or add, prescription of a “typical” presbyopic patient. The movement assembly 66 may be configured to provide accommodative movement by producing relative motion between theoptic body 64 and at least portion of the movement assembly 66. Alternatively, the movement assembly 66 may be configured to maintain a fixed or substantially fixed relationship between theoptic body 64 and the movement assembly 66. In such embodiments, accommodation may be provided when both the movement assembly 66 and theoptic body 64 move together relative to the retina of the eye as the capsular bag moves and/or changes shape during accommodation. -
FIG. 5 illustrates another ILC, shown generally at 360, in accordance with the present invention. Except as expressly described herein,ILC 360 is structured and functions similarly toILC 60. Components ofILC 360 which correspond to components ofILC 60 are identified by the same reference numeral increased by 300. - One primary difference between
ILC 360 andILC 60 relates to the positioning of compensatingoptic body 362. Specifically, compensatingIOL 361 is located inanterior chamber 90 ofeye 374.Fixation member 368 is coupled to the compensatingoptic body 362 and extends outwardly and comes in contact with theangle 92 ofeye 374. The arrangement of compensatingoptic body 362 andfixation member 368 is such that the compensating optic body is maintained in a substantially stationary position in theanterior chamber 90 ofeye 374. The primaryoptic body 364 is adapted to be moved axially alongoptical axis 382 ofeye 374 by theciliary muscle 378 andzonules 380 acting on themovement assembly 366. - Still another embodiment of an ILC according to the present invention is shown in
FIG. 7 , indicated generally at 560. Except as expressly described herein,ILC 560 is structured and functions similarly toILC 60. Components ofILC 560 which correspond to components ofILC 60 are identified by the same reference numeral increased by 500. - Again,
ILC 560 differs fromILC 60 primarily in the location of the compensatingIOL 561, which is located in thecapsular bag 76 with the primaryoptic body 564, rather than in the sulcus or anterior chamber. In this configuration, the compensatingoptic body 562 would not be truly stationary since thecapsular bag 76 itself typically moves about 0.4 mm during accommodation. However, axial movement of the compensatingoptic body 562 relative thecapsular bag 76 can be limited by appropriate design of the fixation member ormembers 568. Controlling other factors such as material selection, length, width and angulation of the fixation member or members 58 relative the compensatingoptic body 562 can limit the overall axial movement of the compensatingoptic body 562 to less than 0.5 mm which, for the purposes of this invention, can be regarded as “substantially fixed.” - A preferred method of implanting an ILC will now be discussed. The method is equally effective for the embodiments of
FIGS. 5, 6 , and 7, but for purposes of illustration will be discussed specifically with reference toFIG. 7 . - Initially, the
primary IOL 563 is inserted through an incision in the patient's cornea and positioned in thecapsular bag 76 using conventional techniques. Preferably, the incision is less than 4 mm in length. If the primaryoptic body 564 andmovement assembly 566 are unitary as illustrated, they are inserted simultaneously. However, it is also possible to implant anindependent movement assembly 566 first, and then insert the primary optic body in themovement assembly 566. - After the
primary IOL 563 is placed in thecapsular bag 76, a measurement is taken to determine the location of the primaryoptic body 564 relative to theoptical axis 82. If desired, refractive measurements may also be made at this time to accurately determine an appropriate prescription for the compensatingIOL 561. - If the original incision is still open, the compensating
IOL 561 is inserted through the same incision using conventional techniques. If the incision has closed, a new one, preferably also measuring less than 4 mm, is made before insertion. A keratoscope or similar instrument is then used to guide the surgeon in positioning the fixation member ormembers 568 such that compensatingoptic body 562 and the primaryoptic body 564 are axially aligned with theoptical axis 82 and one another. If necessary, the primaryoptic body 564 may also be repositioned at this time. - Alignment of the two
optic bodies optic body 564. Visual confirmation of alignment can be facilitated by providing the compensatingoptic body 562 with a diameter DCB equal to the diameter DPB of the primaryoptic body 564. - In addition, the
ILC 560 can be made less sensitive to decentration by increasing the diameter of the optic zone, that is the portion of the optic body which has corrective power, in one or both of theIOLs IOLS optic bodies - Another factor influencing centration is the flexibility of fixation member or
members 568, Preferably the member ormembers 568 are sufficiently flexible to allow the surgeon to reposition them as needed during the implantation process, but stiff enough to remain in a substantially fixed axial and radial position once implanted. -
FIG. 6 illustrates a still further embodiment of an intraocular lens in accordance with the present invention. This intraocular lens, shown generally at 400 includes anoptic body 401 and four (4) equally spaced apartmovement members 403. Each of themovement members 403 includes adistal region 405 and aproximal region 407 which is coupled to theoptic body 401. A hinge, for example, a linear hinge, such as a reducedthickness area 409, is located near theproximal end 407 of each of themovement members 403, A linear hinge is particularly advantageous to achieve enhanced, or even substantially maximum theoretical, axial movement. - The
IOL 400 can be used in place of the various second optic/movement assembly subcombinations noted above. One distinction betweenIOL 400 and these other subcombinations is the use of four (4)individual movement members 403 which do not totally circumscribe theoptic body 401 relative to the movement assemblies noted previously which fully circumscribe the second optics. It should be noted that the movement assemblies of the present ILCs can have other configurations, for example, which are effective to facilitate or even enhance the movement of the second optics. -
FIGS. 8-11 illustrate another embodiment of the present invention in which anophthalmic device 600 comprises aprimary optic 602 and asupplemental optic 604. Theoptics eye 607 of a patient or subject having a basic prescription (e.g., a basic prescription for distant or near vision) and are generally disposed about anoptical axis 608. Theprimary optic 602 has a base optical power Pbase that may be selected to provide or approximately provide the basic prescription of the subject. For example, the base optical power may be selected to be within ±4 Diopters of the basic prescription, preferably within ±2 Diopters of the basic prescription, even more preferably within ±1 Diopter of the basic prescription. - The
supplemental optic 604 comprises ananterior surface 605 and aposterior surface 606 that are configured to provide a supplemental optical power Psupplemental. In addition, thesupplemental optic 604 may be configured to provide, in combination with theprimary optic 602, a combined optical power Pcombined (e.g., Pbase+Psupplemental) that is capable of providing the basic prescription of the patient. In certain embodiments, the supplemental optical power is selected or configured to modify the vision correction provided by theprimary optic 602 by an amount that allows the combination to provide or substantially provide the basic prescription for at least one configuration of theprimary optic 602. For example, the supplemental optical power may be selected such that the combined optical power is within 1 Diopter of the basic prescription. Generally, theprimary optic 602 is configured to provide vision correction that is nearly equal to the patient's basic prescription for distant vision and thesupplemental optic 604 is used to modify the vision correction provided by theprimary optic 602 so as to more precisely provide the patient's basic prescription. In such cases, the supplemental optical power of thesupplemental optic 604 is less than the primary optical power of theprimary optic 602. For example, theprimary optic 602 may have an optical power that is greater than 20 Diopters and the base optical power is greater than the supplemental optical power by at least 10 Diopters. - The
ophthalmic device 600 is configured to produce ocular accommodation, for example, by configuring at least one surface of theprimary optic 602 to be adeformable surface 610 that is able to deform in response to an ocular force. The resulting deformation may produce a change in the radius of curvature or of a conic constant of at least one surface of theprimary optic 602. In addition, the thickness of the optic 602 is generally changed as it deforms. Deformation of the optic 602 generally results in a change in the optic properties of the optic 602, for example, a change in the optical power or aberrations produced by theoptic 602. - The
primary optic 602 is generally configured to produce an add power that modifies the primary optical power and/or the combined optical power by at least about 1 Diopter, preferably by at least 2 Diopters, and more preferably by at least 3 Diopters. The add power is a change in optical power that allows the eye to focus on objects that are at distances from about 30 cm to about 2 meters in addition to distant objects located at distances that are greater than 2 meters. The accommodative capability or add power provided by deformation of thesurface 610 may be supplemented by axial motion or travel of theprimary optic 602 along theoptical axis 608 in response to the ocular force, as discussed in greater detail above. - As used herein, the term “ocular force” means any force produced by the eye of a subject that stresses, moves, or changes the shape of the natural lens of the eye or of at least a portion of an optic or intraocular lens that is placed in the eye of a subject. The ocular force acting on a lens (either a natural lens or an intraocular lens) may be produced, for example, by the state or configuration of the ciliary body (e.g., contracted or retracted), changes in the shape of the capsular bag of the eye, stretching or contraction of one or more zonules, vitreous pressure changes, and/or movement of some part of the eye such as the ciliary body, zonules, or capsular bag, either alone or in combination.
- As used herein the terms “prescription” or “basic prescription” means an amount of optical power of a lens or an optic that is able to provide normal or functional vision to a subject when viewing objects located at a specified distances from the subject. For example, a “basic prescription for distant vision” is an amount of optical power for a lens or an optic that will allow a subject to resolve distant objects with a predetermined amount of visual acuity (e.g., to resolve the letters on a Snellen eye chart disposed at a distance of 20 feet from the subject with a visual acuity of at least 20/20, 20/30, or 20/40, based on the standard Snellen test for visual acuity).
- As used herein the phrase “provide a basic prescription” (e.g., for distant, intermediate, or near vision) means to provide a lens or an optic that allows a subject to resolve objects at a specified distance with a predetermined degree of visual acuity (e.g., to resolve
objects 20 feet from a subject with a visual acuity of at least about 20/40, more preferably of at least 20/30, and even more preferably of at least 20/20). As used herein, the phrase “substantially provide a basic prescription” (e.g., for distant vision or for near vision) means to provide an ophthalmic device, intraocular lens, or other internal optic that may be combined with an external lens, such as a spectacle lens or a contact lens, to allow a subject to resolve objects with a predetermined amount of visual acuity. The external lens typically has an optical power that is within a range of ±4 Diopters, preferably within a range of ±3 Diopters, and more preferably within a range of ±1 Diopter. - In certain embodiments, the
primary optic 602 may be deformed by using arigid optic 611 that is configured to deform theprimary optic 602 in a predetermined manner, so as to produce accommodation or some other desired effect (e.g., changing the aberrations of theprimary optic 602 and/or the wavefront that is directed to the retina of the eye 607). Theoptics deformable surface 610 is deformed when theoptics FIG. 10 withFIG. 11 . Thus, themovement assembly 620 is structured to cooperate with the eye to effect accommodating axial movement of theprimary optic 602 and accommodating deformation of theprimary optic 602 in response to an ocular force produced by theeye 607. - The
rigid optic 611 may be configured as a meniscus lens having no or substantially no optical power. Alternatively, therigid optic 611 may be a meniscus or some other type of lens having either a positive or negative optical power and/or may have other optical properties such as the ability to compensate for optical aberrations and/or form a multifocal image on the retina when theeye 607 in an accommodative or disaccommodative state. In some embodiments, therigid optic 611 has an optical power (and/or some other optical characteristic) and either replaces or supplements thesupplemental optic 604. The structure and function of the movement assemblies similar to thatmovement assembly 620 in the illustrated embodiment are described in greater detail in U.S. Pat. No. 6,443,985, and U.S. Patent Application Publication Numbers 2004/082994 and 2004/0111153, which are all herein incorporated by reference. - One advantage of embodiments of the current invention is an increased ability to achieve a predetermined optical power or refractive outcome (e.g., the ability to resolve both distant objects and object at a reading distance of about 30 cm with a resolution of 20/30 or better). It will be appreciated that prior to implantation of an intraocular lens, the basic prescription for an aphakic eye and/or amount of accommodative capability of the eye may not be precisely known, since the precise contribution of the natural lens alone may not be precisely determinate. In certain embodiments of the present invention, the deformable
primary optic 602 is implanted into theeye 607 to substantially provide the basic prescription for both distant and near vision (for example within ±2 Diopter). The patient may then be refracted in the usual manner to obtain a more accurately determination of the basic prescription for both distant and near vision. The optical power of thesupplemental optic 604 may then be selected to provide the predetermined optical power or refractive outcome. - Another advantage of embodiments of the current invention is that a predetermined performance of an accommodating intraocular lens may be achieved when used in a variety of different eyes requiring intraocular lenses with different amounts of optical power. The inventors have observed that the image quality or amount of aberrations produced by a deformable optic change as the optic is deformed from one shape to another. The inventors have further observed that the amount of change in the image quality and/or aberrations can be controlled by proper selection of design parameters such as the thickness of the optic, the base optical power in an unstressed state, the material, etc. A
primary optic 602 may be produced with a particular geometry and/or base optical power that has an optimized or predetermined optical performance over a range of add powers as compared to other geometries and/or base optical powers. This optimizedprimary optic 602 may be used in a variety of patients having different basic prescriptions to provide the same quality of accommodative performance for each. In order to provide each patient with their particular basic prescription, a differentsupplemental optic 604 with a different supplemental power for each, thesupplemental optic 604 being selected in each case to provide the correct total power when used in combination with theprimary optic 602. - Yet another advantage of embodiments of the current invention is that the
supplemental optic 604 is a corrector optic that is selected to provide a predetermined refractive outcome in terms of optical performance or image quality of the eye and/or theophthalmic device 600. In such embodiments, thesupplemental optic 604 may have no or substantially no optical power or may have an optical power that is combined with the optical power of theprimary optic 602 to provide near vision, distant vision, or intermediate vision. In some embodiments, thesupplemental optic 604 enhances optical performance or image quality by correcting or reducing an aberration such as a chromatic aberration or a monochromatic aberration of the eye and/orophthalmic device 600. For example, one or both of thesurfaces ophthalmic device 600. Alternatively or additionally, at least one thesurfaces ophthalmic device 600. Thesupplemental optic 604 may be configured to favorably modify the aberrations when theprimary optic 602 is in an accommodative and/or disaccommodative state. - In certain embodiments, the
supplemental optic 604 is a corrector optic that is configured increase the depth of focus of the eye, for example, by changing the optical power or focal length of thesupplemental optic 604 as a function of distance from the optical axis thereof. In other embodiments, thesupplemental optic 604 is configured to produce two or more simultaneous foci (e.g., a bifocal or multifocal lens). In such embodiments, at least one of thesurfaces supplemental optic 604 may comprise a diffractive phase plate that produces two or more diffraction orders. Alternatively, at least one of thesurfaces optical axis 608. - The
primary optic 602 may be placed within acapsular bag 612, as illustrated inFIGS. 10 and 11 , so that theophthalmic device 600 is responsive to ocular forces produced byciliary muscle 614 and/orzonules 618. Alternatively, theprimary optic 602 may be implanted elsewhere within theeye 607. For example, the anterior and posterior capsules of thecapsular bag 612 may be allowed to attach to one another and theophthalmic device 600 implanted within the sulcus of theeye 607 so that theprimary optic 602 is disposed in front of thecapsular bag 612. In certain embodiments, theprimary optic 602 has an optical power of at least about 10 Diopters, at least 20 Diopters, or at least 30 Diopters. In other embodiments, theprimary optic 602 has a negative optical power, for example less than −5 Diopters, less than −10 Diopters, or less than −20 Diopters. In yet other embodiments, theprimary optic 602 has an optical power within the range of −30 to +40 Diopters, −20 to +30 Diopters, or −10 to +20 Diopters. - In certain embodiments, a patient has a basic prescription for distant vision that is expressed in terms of an optical power Pdistant. The difference between the optical power Pdistant and the base optical power Pbase of the
primary optic 602 may be calculated and based on the ability of a surgeon or other practitioner to estimate the required basic prescription for distant vision, theprimary optic 602 alone may be sufficient to restore both the distant and/or near vision of a patient to a degree that allows normal vision to be provided at least by the use of an external lens. In certain embodiments, the surgeon or practitioner is able to select the base optical power Pbase to be within ±4 Diopters of the basic prescription (e.g., abs (Pdistant−Pbase)≦4 Diopters), preferably within ±2 Diopter of the basic prescription, more preferably within +1 Diopter of the basic prescription. In other embodiments, the base optical power Pbase is within a range of zero to −4 Diopters of the basic prescription for distant vision, preferably within a range of zero to −2 Diopters, more preferably within a range of zero to −1 Diopters. - By selecting the optical power Pbase of the
primary optic 602 to be within at least one of these ranges, theprimary optic 602 is able to provide normal vision over at least some distances. For example, if (Pdistant−Pbase) is equal to −3 Diopters after implantation of theprimary optic 602, the patient would have blurred distant vision, but a high degree of visual acuity at normal reading distances without the need for additional internal lenses (e.g. the supplemental optic 604) and/or external lenses (e.g., spectacles or contact lenses). In certain embodiments, the optical power Psupplemental of thesupplemental optic 604 is selected so that the combined optical power Pcombined is equal to or approximately equal to the basic prescription for distant vision (e.g., so that (Pdistant−Pcombined) is approximately equal to zero). - The
supplemental optic 604 may be configured to be implanted together with theprimary optic 602 or separately therefrom. In some embodiments, thesupplemental optic 604 is only optionally implanted into theeye 607 when the actual vision provided by theprimary optic 602 differs by a predetermined amount from an expected refractive outcome and/or the prescription of the patient changes by predetermined amount over time after initial implantation of theprimary optic 602 and/orsupplemental optic 604. Thesupplemental optic 604 may be disposed in front of the iris or in the anterior chamber of theeye 607, as illustrated for example inFIGS. 10 and 11 . Alternatively, thesupplemental optic 604 may be disposed within the vicinity of the sulcus of theeye 607, together with theprimary optic 602 withincapsular bag 612, or slightly protruding from thecapsular bag 612. In other embodiments, thesupplemental optic 604 may be disposed within acornea 619 of the eye as a corneal implant. In yet other embodiments, thesupplemental optic 604 may be a corneal implant disposed configured to be disposed within thecornea 619 or a surface profile disposed on or within thecornea 619, the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure). - The primary and
supplemental optics eye 607 so as to maintain a separation therebetween that is greater than a predetermined minimum, for example 200 micrometer, 500 micrometers, or about 1 millimeter. Alternatively, the primary andsupplemental optics eye 607 so as to press against one another while theeye 607 is in an accommodative and/or disaccommodative state and/or between an accommodative and a disaccommodative state. - At least one surface of the
primary optic 602, for example thedeformable surface 610, is configured to deform in response to an ocular force so as to modify the optical power of at least one of (1) theprimary optic 602, (2) the combined optical power of theoptics entire eye 607. The deformation may be the result of change in the radius of curvature as theprimary optic 602 changes from an accommodative state and disaccommodative state, which results in a change in the optical power or focal length of theprimary optic 602. Alternatively or additionally, at least one surface of theprimary optic 602 may change from a spherical profile to an aspheric profile or from a more spherical profile to a less spherical profile as theprimary optic 602 changes from an accommodative state and disaccommodative state, or visa versa, wherein the profile change produces a change in optical power or in some other optical characteristic of theprimary optic 602. In other embodiments, theprimary optic 602 may change from a monofocal lens to a multifocal lens (either refractive or diffractive) as theprimary optic 602 changes from an accommodative state and disaccommodative state, or visa versa. Alternatively, theprimary optic 602 may be a multifocal lens, wherein the optical power or some other optical characteristic of the zones changes as theprimary optic 602 changes between accommodative state and disaccommodative states. - In certain embodiments, the
primary optic 602 has a center thickness ti along theoptical axis 608 when in a substantially unstressed state and a center thickness tf in the response to or in the absence of an ocular force. In such embodiments, theprimary optic 602 may be adapted to change the center thickness by a factor of at least 1.1 (e.g., the quotient tf/ti is at least 1.1), typically when the ocular force is in the range of about 1 to 10 grams, preferably in the range of about 5 to 10 grams. In other embodiments, theprimary optic 602 is adapted to change the center thickness by a factor of at least 1.05 or at least 1.2 or more. In yet other embodiments, theprimary optic 602 is adapted to change the center thickness by a factor of at least 1.05, 1.1, or 1.2 when the ocular force is in the range of about 1 to 5 gram or about 1 to 3 grams. In still other embodiments, theprimary optic 602 has a center thickness along theoptical axis 608 when theprimary optic 602 is in a substantially unstressed state, the deformable optic adapted to change the center thickness by at least about 50 micrometers, preferably at least 100 micrometers, when the ocular force is in the range of about 1 to 9 grams, in the range of about 6 to 9 grams, or in the range of about 1 to 3 grams. Within the art, an understanding of the physiology of the eye is still developing. Thus, other ranges of ocular forces able to provide the above ranges of relative and/or absolute thickness change are anticipated as the physiology of the eye is better understood. Such ranges of ocular forces are also consistent with embodiments of the present invention as disclosed herein. - The modification in optical power as the
primary optic 602 deforms is preferably at least 1 Diopter, more preferably at least 2 Diopters or 3 Diopters, and even more preferably at least 2 to 4 Diopters or 3 to 5 Diopters. The amount of change in optical power ofprimary optic 602 is generally an effective Diopter change in the optical power, for example, from a principal plane of the primary optic 602 (e.g., somewhere between the anterior and posterior surfaces of primary optic 602). In general, and as illustrated inFIGS. 10 and 11 , the Diopter change may be a positive change as theciliary muscle 614 contracts and thezonules 618 relax; however, other directions and/or types of Diopter change are allowable (e.g., multifocal and/or aberration changes). - In the illustrated embodiment, the
ophthalmic device 600 comprises amovement assembly 620 that is operably coupled to theprimary optic 602 and afixation member 622 that is operably coupled to thesupplemental optic 604. Alternatively, thesupplemental optic 604 may be coupled to themovement assembly 620 or comprise its own, separate movement assembly. Themovement assembly 620 comprises ananterior portion 624 that engages the anterior capsule of thecapsular bag 612 and aposterior portion 628 that engages the posterior capsule of thecapsular bag 612. The anterior andposterior portions capsular bag 612. Themovement assembly 620 may further comprise a plurality ofarms 630 that are configured to pivot, rotate, bend and/or otherwise deform in response to deformation of themovement assembly 620, whereby theprimary optic 602 may be moved and/or deformed to provide accommodation. The anterior andposterior portions movement assembly 620 conforms and remains in contact with thecapsular bag 612 during accommodative movement thereof. - The embodiment illustrated in
FIGS. 8-11 of theprimary optic 602, thesupplemental optic 604, and structures connected to theoptics primary optic 602 may be configured to have a posterior vault rather than the anterior vault illustrated inFIGS. 10 and 11 , in which case thedeformable surface 610 is pressed against the posterior capsule of thecapsular bag 612 when theciliary muscle 614 contracts and the shape of thecapsular bag 612 changes. In certain embodiments, the ILC illustrated inFIG. 7 is used to provide such a configuration, wherein the posteriorly vaultedprimary IOL 563 is made of a material that is sufficiently soft to deform in response to ocular forces and the compensatingIOL 561 is configured as a supplemental optic. Other examples of devices and means for producing a predetermined amount of accommodation in response to an ocular force may be found, for example, in U.S. patent application Ser. No. 11/241,586, which is herein incorporated by reference. - The
ophthalmic device 600 may be used in a surgical procedure to restore both distant vision and accommodative ability for providing near vision. Referring toFIG. 12 , in some embodiments, amethod 700 of providing accommodative vision comprises anoperational block 702, making a first estimate of a basic prescription of a subject. Themethod 700 also comprises anoperational block 704, inserting theprimary optic 602 into theeye 607 of the subject. Themethod 700 further comprises anoperational block 706, which includes making a second estimate of the basic prescription of the subject based on the presence of theprimary optic 602. The method additionally comprises anoperational block 708, implanting thesupplemental optic 604 into theeye 607. - In the
operational block 702, the surgeon make a first estimate of the basic prescription of the patient by, for example, measuring physical characteristic of the eye such as the axial length (AL) and the anterior chamber depth (ACD). Other dimensional parameters may also be measured including, but are not limited to, the corneal radius (CR), the corneal power (K), and crystalline lens thickness (LT). The first estimate may also include other parameters of the eye such as the refractive indices and/or estimated refractive indices of the various portions of the eye. The estimate may additionally or alternatively include performing one or more interactive vision tests with the subject, for example using the standard Snellen test for visual acuity. Generally, the first estimate is determined while the natural lens or a previously implanted intraocular lens is still in the eye. In some embodiments, the first estimate may be made after removal of the natural lens and/or explanting a previously implanted intraocular lens. - In some embodiments, the estimates of the basic prescription are made using ophthalmic instruments designed to measure physical properties of the eye or wavefront aberrations produced by the eye, for example using biometry or keratometry. Corneal surface measurements according to well-known topographical measurement methods may be used that express surface irregularities of the cornea. Corneal measurements for this purpose can be performed by the ORBSCAN.RTM. videokeratograph available from Orbtech or by corneal topography methods, such as EyeSys.RTM available from Premier Laser Systems. The corneal measurements may also include the measurement of the corneal refractive power. In addition, wavefront sensors such as the Hartmann-Shack sensor (J. Opt. Soc. Am., 1994, Vol. 11(7), pp. 1949-57) may also be used to determine aberrations of the eye. The wavefront sensor may be used in combination with topographic sensors to determine other physical characteristics of the eye such as its length.
- In the
operational block 704, the surgeon implants theprimary optic 602 into theeye 607. In certain embodiments, theprimary optic 602 is selected to have a base optical power Pbase that substantially provides the basic prescription and is within at least ±4 Diopters of the basic prescription. Since theprimary optic 602 substantially provides a basic prescription and in addition has the ability to provide accommodation, theprimary optic 602 advantageously allows a surgeon to use a single implanted optic to provide a patient both distant and near vision. In some cases, satisfactory distant vision and near vision may be restored using only theprimary optic 602, without the need of implanting thesupplemental optic 604 or using other external lenses. In other cases, the basic prescription is provided only for certain distances or the vision provided is within an acceptable range to allow a more accurate estimate of a patient's prescription for both near and distant vision. In such cases, both distant and near vision may be restored using a single prescription spectacle or contact lens, since theprimary optic 602 provides accommodative ability. Alternatively, thesupplemental optic 604 may be implanted to restore full vision of both distant and near objects. In addition, because theprimary optic 602 is able to substantially provides the basic prescription, a more accurate estimate of the aberrations ofeye 607 may be made and subsequently corrected or compensated for using either an external optic and/or thesupplemental optic 604. - In
operational block 706, the surgeon may make the second estimate of the basic prescription either at the time of the surgery or at a time shortly after the implantation of the primaryophthalmic device 600. Alternatively, the second estimate may be made at a later time by the surgeon or by another practitioner, such as an optometrist, after the subject has more fully recovered from the surgical procedure. In some instances, the time between the implantation of theprimary optic 602 and the second estimate is an extended period of time in order to allow the eye to recover from the surgical procedure. The period of time may be one week, one month, or even several months (from at least about three months to at least about 6 months). Also, in some cases, the basic prescription may change some time after implantation of the primary optic 602 (perhaps for causes unrelated to the surgical procedure), thereby necessitating a second estimate and correction of the subject's vision. In cases where an implantedsupplemental optic 604 must be explanted in order to restore proper vision, the difficulty of explanting is advantageously reduced using theophthalmic device 600, since thesupplemental optic 604 may be made relatively thin and is disposed in front of theprimary optic 602 and nearer to the front of the eye 607 (e.g., in the anterior chamber in the illustrated embodiment). - In certain embodiments, the
primary optic 602 and/or thesupplemental optic 604 belong to a system or set of intraocular lenses. In some embodiments, the set of optics comprises a singleprimary optic 602 and a set or plurality S1 ofsupplemental optics 604. The singleprimary optic 602 may configured to provide an approximate correction for predetermined population, for example a population of patients with eyes having a particular range of axial lengths or type or shape of cornea, while thesupplemental optic 604 is selected from the set S1 ofsupplemental optics 604 to provide a more precise correction for a particular individual within the population. Theprimary optic 602 may have a base optical power selected to be at or near the average basic prescription for a particular population. Alternatively or additionally, theprimary optic 602 may be configured to provide a predetermined optical quality over a range of expected amounts of a particular optical aberration for a particular population. - Each of the
supplemental optics 604 from the set S1 ofsupplemental optics 604 may be configured to vary from one another in optical power by a predetermined amount. For example, thesupplemental optics 604 may be configured to vary by ½ Diopter, ¼ Diopter, or less than ¼ Diopters from one another. In this manner, theprimary optic 602 is implanted to provide and approximate correction of vision for the patient and a predetermined optical performance over range of accommodation add powers. - In other embodiments, the
primary optic 602 is selected from plurality or set P2 ofprimary optics 602 and thesupplemental optic 604 is selected from a set or plurality S2 ofsupplemental optics 604. Since there is more oneprimary optic 602 for providing an approximate correction of the eyes in a given population, the number of optics in the set S2 ofsupplemental optics 604 may be relatively small, for example as compared to the number of optics in the set S1 previously discussed. Alternatively, the optics in the sets P2 ofprimary optics 602 and in the set S2 ofsupplemental optics 604 may be configured to provide visual correction for populations having variations in basic prescription that are too large to be covered using only a singleprimary optic 602, as in the previous embodiment. - Referring to
FIG. 13 , in certain embodiments, theophthalmic device 600 comprises a corrector optic 604 c configured to correct the optical power of theprimary optic 602, wherein theprimary optic 602 may be configured to have a base optical power that is selected to provide a patient's basic prescription for at least one of distant vision, intermediate vision, or near vision. The corrector optic 604 c may be configured to correct a monochromatic aberration and/or a chromatic aberration of, for example, theprimary optic 602, thecornea 619, and/or an overall aberration of theeye 607. The corrector optic 604 c may have an overall positive or negative optical power, for example, within a range of about −4 Diopters to +4 Diopters or in a range of −2 Diopters to +2 Diopters. Also, the corrector optic 604 c may be a multifocal lens and/or provide cylinder correction. Alternatively, the corrector optic 604 c may have no or substantially no overall optical power and be used primary to correct an aberration ofprimary optic 602 or theeye 607. When the corrector optic 604 c has no or substantially no optical power, theprimary optic 602 generally has a base optical power that provides the patient's basic prescription. In some embodiments, the basic prescription will be the basic prescription for distant vision; however, the basic prescription may alternatively the basic prescription for intermediate or near vision. - The corrector optic 604 c may be disposed in the sulcus, as illustrated in
FIG. 11 . Alternatively, the corrector optic 604 c may be disposed in the anterior chamber, similar to the location of thesupplemental optic 604 inFIGS. 9 and 10 . In other embodiments, the corrector optic 604 c may be a corneal implant configured to be disposed within thecornea 619 or a surface profile disposed on or within thecornea 619, the profile being formed by a laser (e.g., using a LASIK, LASEK, or PRK procedure). In yet other embodiments, the corrector optic 604 c is therigid optic 611 configured to deform theprimary optic 602 in a predetermined manner. In such embodiments, theoptics 602, 604 c are configured such that thedeformable surface 610 of theprimary optic 602 is deformed when theoptics 602, 604 c are pressed together. - The corrector optic 604 c may be used to correct monochromatic and/or chromatic aberrations of the
ophthalmic device 600, theeye 607 of an individual, or a population of eyes. The corrector optic 604 c may be a purely refractive optical element or may additionally or alternatively comprise a diffractive element, for example, as discussed in U.S. Pat. Nos. 4,642,112, 4,881,805, and 5,144,483, which are herein incorporated by reference. Diffractive elements may be especially useful for correcting chromatic aberrations and may be configured to provide either monofocal or multifocal lens. When the corrector optic 604 c is purely refractive, it may be configured to correct a chromatic aberration by combining a plurality of optical elements that are each made of a different material having different optical characteristics (e.g., different refractive indices and/or Abbe numbers). Monochromatic aberrations that may be corrected by the corrector optic 604 c include, but are not limited to, astigmatic, spherical, and/or comatic. Correction of such aberrations is discussed in greater detail, for example, in U.S. Pat. Nos. 5,777,719, 6,609,793, and 6,830,332, which are herein incorporated by reference. - In some embodiments, the
primary optic 602 is a corrector optic that may be used to correct or compensate for an optical aberration of theeye 607 and/or thesupplemental optic 604. In other embodiments, theprimary optic 602 and thesupplemental optic 604 together correct or compensate for an optical aberration of at least a portion of theeye 607. For example, theprimary optic 602 may be configured to correct astigmatism produced by thecornea 619, while thesupplemental optic 604 is selected to correct a spherical aberration of thecornea 619. Alternatively or additionally, theprimary optic 602 may be configured to correct a spherical aberration of thecornea 619 based on a preliminary estimate before theprimary optic 602 is implanted into theeye 607. Thesupplemental optic 604 may then be select to have a spherical aberration that compensates for any remaining spherical aberrations resulting from implantation of theprimary optic 602. - In certain embodiments, the corrector optic 604 c is selected from a plurality or set S3 of corrector optics 604c, wherein each of the corrector optics 604 c from the set S3 has a predetermined value of an optical characteristic that is different from the value of that optical characteristic for the other corrector optics 604 c within the set S3. At least one of the corrector optics 604 c in the set S3 is configured to provide, in combination with the
primary optic 602, the basic prescription of the patient for at least one of distant vision, near vision, or intermediate vision. - While this invention has been described with respect to various specific examples and embodiments, it is to be understood that the invention is not limited thereto and that it can be variously practiced within the scope of the following claims.
Claims (32)
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US14/160,321 Expired - Fee Related US9814570B2 (en) | 1999-04-30 | 2014-01-21 | Ophthalmic lens combinations |
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US14/160,321 Expired - Fee Related US9814570B2 (en) | 1999-04-30 | 2014-01-21 | Ophthalmic lens combinations |
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EP (1) | EP2043558A2 (en) |
AU (1) | AU2007272697A1 (en) |
CA (1) | CA2661704A1 (en) |
WO (1) | WO2008008627A2 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040088050A1 (en) * | 2000-05-23 | 2004-05-06 | Sverker Norrby | Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations |
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US20090234448A1 (en) * | 2007-08-27 | 2009-09-17 | Advanced Medical Optics, Inc. | Intraocular lens having extended depth of focus |
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US20100097569A1 (en) * | 2008-10-20 | 2010-04-22 | Advanced Medical Optics, Inc. | Multifocal Intraocular Lens |
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US8579970B1 (en) | 2005-06-27 | 2013-11-12 | Visiogen, Inc. | Magnifying intraocular lens |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Citations (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US34988A (en) * | 1862-04-15 | Improvement in sewing-machines | ||
US1483509A (en) * | 1921-05-05 | 1924-02-12 | Franklin Optical Company | Process of making fused bifocal lenses |
US2274142A (en) * | 1940-01-15 | 1942-02-24 | Revalens Co | Multifocal ophthalmic lens |
US3227507A (en) * | 1961-08-16 | 1966-01-04 | Feinbloom William | Corneal contact lens having inner ellipsoidal surface |
US3420006A (en) * | 1964-01-27 | 1969-01-07 | Howard J Barnett | Apparatus for grinding multifocal lens |
US3431327A (en) * | 1964-08-31 | 1969-03-04 | George F Tsuetaki | Method of making a bifocal contact lens with an embedded metal weight |
US3711870A (en) * | 1971-12-07 | 1973-01-23 | R Deitrick | Artificial lens implant |
US3718870A (en) * | 1971-08-12 | 1973-02-27 | Itt | Driving circuit for electro-mechanical oscillators |
US3794414A (en) * | 1972-05-12 | 1974-02-26 | Jessen Inc Wesley | Multiple focal contact lens |
US3866249A (en) * | 1974-03-07 | 1975-02-18 | Leonard Flom | Posterior chamber artificial intraocular lens |
US3932148A (en) * | 1975-01-21 | 1976-01-13 | Criterion Manufacturing Company, Inc. | Method and apparatus for making complex aspheric optical surfaces |
US4010496A (en) * | 1975-10-01 | 1977-03-08 | Neefe Charles W | Bifocal lens which positions within the anterior chamber |
US4014049A (en) * | 1976-04-07 | 1977-03-29 | American Optical Corporation | Artificial intraocular lens and supporting system therefor |
US4073579A (en) * | 1976-06-09 | 1978-02-14 | American Optical Corporation | Ophthalmic lens with locally variable index of refraction and method of making same |
US4074368A (en) * | 1976-09-08 | 1978-02-21 | Said Chauncey F. Levy, Jr., By Said Richard J. Pegis | Intraocular lens with high magnification |
US4195919A (en) * | 1977-10-31 | 1980-04-01 | Shelton William A | Contact lens with reduced spherical aberration for aphakic eyes |
US4199231A (en) * | 1978-08-21 | 1980-04-22 | Evans Carl H | Hydrogel contact lens |
US4244060A (en) * | 1978-12-01 | 1981-01-13 | Hoffer Kenneth J | Intraocular lens |
US4244597A (en) * | 1979-05-29 | 1981-01-13 | Dandl John E | Side mounting assembly for tractor implement |
US4251887A (en) * | 1979-04-02 | 1981-02-24 | Anis Aziz Y | Posterior chamber capsular lens implant and method for implantation of the lens |
US4253199A (en) * | 1978-09-25 | 1981-03-03 | Surgical Design Corporation | Surgical method and apparatus for implants for the eye |
US4254509A (en) * | 1979-04-09 | 1981-03-10 | Tennant Jerald L | Accommodating intraocular implant |
US4261065A (en) * | 1979-07-27 | 1981-04-14 | Tennant Jerald L | Artificial intraocular lens with forward-positioned optics |
US4315673A (en) * | 1978-04-06 | 1982-02-16 | Optische Werke G. Rodenstock | Progressive power ophthalmic lens |
US4315336A (en) * | 1980-01-21 | 1982-02-16 | Stanley Poler | Intraocular lens |
US4316293A (en) * | 1979-08-27 | 1982-02-23 | Bayers Jon Herbert | Flexible intraocular lens |
US4370760A (en) * | 1981-03-25 | 1983-02-01 | Kelman Charles D | Anterior chamber intraocular lens |
US4373218A (en) * | 1980-11-17 | 1983-02-15 | Schachar Ronald A | Variable power intraocular lens and method of implanting into the posterior chamber |
US4377329A (en) * | 1980-02-26 | 1983-03-22 | Stanley Poler | Contact lens or the like |
US4377873A (en) * | 1980-10-30 | 1983-03-29 | Reichert Jr Henry L | Intraocular lens |
US4424597A (en) * | 1981-05-13 | 1984-01-10 | Inprohold Establishment | Posterior chamber implant lens |
US4442553A (en) * | 1981-09-17 | 1984-04-17 | Hessburg Philip C | Intraocular lens |
US4503953A (en) * | 1982-06-01 | 1985-03-12 | Rockwell International Corporation | Roller retainer for brake assembly |
US4504982A (en) * | 1982-08-05 | 1985-03-19 | Optical Radiation Corporation | Aspheric intraocular lens |
US4504981A (en) * | 1981-09-28 | 1985-03-19 | Walman Gerald B | Intraocular lens |
US4562600A (en) * | 1983-10-18 | 1986-01-07 | Stephen P. Ginsberg | Intraocular lens |
US4573998A (en) * | 1982-02-05 | 1986-03-04 | Staar Surgical Co. | Methods for implantation of deformable intraocular lenses |
US4573775A (en) * | 1982-08-19 | 1986-03-04 | Vistakon, Inc. | Bifocal contact lens |
US4575878A (en) * | 1981-01-30 | 1986-03-18 | Seymour Dubroff | Intraocular lenses |
US4636049A (en) * | 1983-09-20 | 1987-01-13 | University Optical Products Co. | Concentric bifocal contact lens |
US4636211A (en) * | 1984-03-13 | 1987-01-13 | Nielsen J Mchenry | Bifocal intra-ocular lens |
US4637697A (en) * | 1982-10-27 | 1987-01-20 | Pilkington P.E. Limited | Multifocal contact lenses utilizing diffraction and refraction |
US4641934A (en) * | 1982-09-29 | 1987-02-10 | Pilkington P.E. Limited | Ophthalmic lens with diffractive power |
US4720286A (en) * | 1984-07-20 | 1988-01-19 | Bailey Kelvin E | Multifocus intraocular lens |
US4725278A (en) * | 1985-01-22 | 1988-02-16 | Shearing Steven P | Intraocular lens |
US4731078A (en) * | 1985-08-21 | 1988-03-15 | Kingston Technologies Limited Partnership | Intraocular lens |
US4813955A (en) * | 1983-09-07 | 1989-03-21 | Manfred Achatz | Multifocal, especially bifocal, intraocular, artificial ophthalmic lens |
US4816031A (en) * | 1988-01-29 | 1989-03-28 | Pfoff David S | Intraocular lens system |
US4816032A (en) * | 1987-02-11 | 1989-03-28 | Hetland Jens G | Arrangement in an intraocular anterior chamber lens |
US4890913A (en) * | 1982-10-13 | 1990-01-02 | Carle John T De | Zoned multi-focal contact lens |
US4890912A (en) * | 1986-01-24 | 1990-01-02 | Rients Visser | Trifocal eye-contact lens |
US4892543A (en) * | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
US4898461A (en) * | 1987-06-01 | 1990-02-06 | Valdemar Portney | Multifocal ophthalmic lens |
US4906246A (en) * | 1987-08-24 | 1990-03-06 | Grendahl Dennis T | Cylindrically segmented zone of focus artificial hydrogel lens |
US4990159A (en) * | 1988-12-02 | 1991-02-05 | Kraff Manus C | Intraocular lens apparatus with haptics of varying cross-sectional areas |
US4994083A (en) * | 1986-07-22 | 1991-02-19 | Ceskoslovenska Akademie Ved | Soft intracameral lens |
US4994082A (en) * | 1988-09-09 | 1991-02-19 | Ophthalmic Ventures Limited Partnership | Accommodating intraocular lens |
US5000559A (en) * | 1988-02-29 | 1991-03-19 | Nikon Corporation | Ophthalmic lenses having progressively variable refracting power |
US5002382A (en) * | 1989-12-07 | 1991-03-26 | Leonard Seidner | Multifocal corneal contact lenses |
US5089024A (en) * | 1988-04-19 | 1992-02-18 | Storz Instrument Company | Multi-focal intraocular lens |
US5096285A (en) * | 1990-05-14 | 1992-03-17 | Iolab Corporation | Multifocal multizone diffractive ophthalmic lenses |
US5192318A (en) * | 1986-06-05 | 1993-03-09 | Schneider Richard T | One-piece bifocal intraocular lens construction |
US5192317A (en) * | 1988-07-26 | 1993-03-09 | Irvin Kalb | Multi focal intra-ocular lens |
US5275623A (en) * | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
US5480428A (en) * | 1993-04-22 | 1996-01-02 | Mezhotraslevoi Nauchno-Tekhnichesky Komplex "Mikrokhirurgia Glaza" | Corrective intraocular lens |
US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
US5496366A (en) * | 1990-04-27 | 1996-03-05 | Cumming; J. Stuart | Accommodating intraocular lens |
US5593436A (en) * | 1993-05-12 | 1997-01-14 | Langerman; David W. | Capsular bag implants with dual 360 ring structures for inhibiting posterior capsular opacification |
US5607472A (en) * | 1995-05-09 | 1997-03-04 | Emory University | Intraocular lens for restoring accommodation and allows adjustment of optical power |
US5876442A (en) * | 1998-01-15 | 1999-03-02 | Visioncare Ltd. | Intraocular lens implant with telescope support |
US6013101A (en) * | 1994-11-21 | 2000-01-11 | Acuity (Israel) Limited | Accommodating intraocular lens implant |
US6176878B1 (en) * | 1998-12-17 | 2001-01-23 | Allergan Sales, Inc. | Accommodating intraocular lens |
US6197058B1 (en) * | 1999-03-22 | 2001-03-06 | Valdemar Portney | Corrective intraocular lens system and intraocular lenses and lens handling device therefor |
US6197059B1 (en) * | 1990-04-27 | 2001-03-06 | Medevec Licensing, B.V. | Accomodating intraocular lens |
US6200342B1 (en) * | 1999-05-11 | 2001-03-13 | Marie-Jose B. Tassignon | Intraocular lens with accommodative properties |
US20030004569A1 (en) * | 2000-02-03 | 2003-01-02 | Haefliger Eduard Anton | Lens implant |
US6503276B2 (en) * | 1998-11-10 | 2003-01-07 | Advanced Medical Optics | Accommodating multifocal intraocular lens |
US6524340B2 (en) * | 2001-05-23 | 2003-02-25 | Henry M. Israel | Accommodating intraocular lens assembly |
US6533813B1 (en) * | 2001-09-07 | 2003-03-18 | Chwen Yih Lin | Intraocular lens that may accommodate automatically |
US20030060881A1 (en) * | 1999-04-30 | 2003-03-27 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US20030060878A1 (en) * | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US20040015236A1 (en) * | 1991-11-18 | 2004-01-22 | Sarfarazi Faezeh M. | Sarfarazi elliptical accommodative intraocular lens for small incision surgery |
US6695881B2 (en) * | 2002-04-29 | 2004-02-24 | Alcon, Inc. | Accommodative intraocular lens |
US20040039446A1 (en) * | 2002-08-26 | 2004-02-26 | Advanced Medical Optics, Inc. | Accommodating intraocular lens assembly with multi-functional capsular bag ring |
US6846326B2 (en) * | 2001-01-25 | 2005-01-25 | Visiogen, Inc. | Connection geometry for intraocular lens system |
US20050018504A1 (en) * | 2003-07-23 | 2005-01-27 | Filippo Marinelli | Array of non volatile split-gate memory cells for avoiding parasitic programming and programming method thereof |
US20050027354A1 (en) * | 2003-07-28 | 2005-02-03 | Advanced Medical Optics, Inc. | Primary and supplemental intraocular lens |
US6855164B2 (en) * | 2001-06-11 | 2005-02-15 | Vision Solutions Technologies, Llc | Multi-focal intraocular lens, and methods for making and using same |
US20050060032A1 (en) * | 2001-06-22 | 2005-03-17 | Peter Magnante | Accommodating intraocular lens |
US7018409B2 (en) * | 2002-09-13 | 2006-03-28 | Advanced Medical Optics, Inc. | Accommodating intraocular lens assembly with aspheric optic design |
US20070010882A1 (en) * | 2003-02-21 | 2007-01-11 | Barrett Graham D | Intraocular lens |
US20070021831A1 (en) * | 2005-07-19 | 2007-01-25 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
US7179292B2 (en) * | 2002-03-15 | 2007-02-20 | Ophtec B.V. | Intraocular lens for implantation in an eye and instrument and methods for insertion of such a lens |
US7503938B2 (en) * | 2002-03-05 | 2009-03-17 | Phillips Andrew F | Method of implanting an accommodating intraocular lens |
US7645300B2 (en) * | 2004-02-02 | 2010-01-12 | Visiogen, Inc. | Injector for intraocular lens system |
US7662180B2 (en) * | 2002-12-05 | 2010-02-16 | Abbott Medical Optics Inc. | Accommodating intraocular lens and method of manufacture thereof |
Family Cites Families (558)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE25286E (en) | 1962-11-13 | Bifocal corneal contact lens | ||
FR488835A (en) | 1915-03-31 | 1918-11-19 | Vickers Ltd | Improvements to warships and other vessels |
US2129305A (en) | 1936-08-21 | 1938-09-06 | Feinbloom William | Contact lens |
US2405989A (en) | 1941-08-12 | 1946-08-20 | Beach Lens Corp | Lens |
US2511517A (en) | 1947-01-31 | 1950-06-13 | Bell & Howell Co | Method of producing optical glass of varied refractive index |
US3004470A (en) | 1956-07-28 | 1961-10-17 | Zeiss Ikon A G Stuttgart | Multiple focal length lens |
US2834023A (en) | 1957-02-06 | 1958-05-13 | Titmus Optical Company Inc | Anterior chamber lenses for refractive correction of aphakia, high ametropia, and anisometropia |
US3031927A (en) | 1958-03-03 | 1962-05-01 | Plastic Contact Lens Company | Bifocal corneal contact lens |
US3222432A (en) | 1958-06-12 | 1965-12-07 | Lentilles Ophtalmiques Rationn | Methods of producing optical and ophthalmic lenses from thermosetting resin materials |
US3034403A (en) | 1959-04-03 | 1962-05-15 | Neefe Hamilton Res Company | Contact lens of apparent variable light absorption |
DE1158281B (en) | 1961-08-03 | 1963-11-28 | Wilhelm Peter Soehnges | Corneal contact lens |
US3339997A (en) | 1962-07-30 | 1967-09-05 | Plastic Contact Lens Company | Bifocal ophthalmic lens having different color distance and near vision zones |
US3210894A (en) | 1962-08-13 | 1965-10-12 | Kollmorgen Corp | Method of producing aspheric surfaces on mirrors or lenses |
US3415597A (en) | 1962-11-20 | 1968-12-10 | Willard J. Harman | Corneal contact lens with offset concave surface portions |
US3305294A (en) | 1964-12-03 | 1967-02-21 | Optical Res & Dev Corp | Two-element variable-power spherical lens |
US3482906A (en) | 1965-10-04 | 1969-12-09 | David Volk | Aspheric corneal contact lens series |
US3507565A (en) | 1967-02-21 | 1970-04-21 | Optical Res & Dev Corp | Variable-power lens and system |
US3542461A (en) | 1967-11-20 | 1970-11-24 | Du Pont | Contact lens having an index of refraction approximating that of human tears |
US3760045A (en) | 1967-12-12 | 1973-09-18 | H Thiele | Process of preparing shaped optical bodies useful as aids to vision |
US3583790A (en) | 1968-11-07 | 1971-06-08 | Polaroid Corp | Variable power, analytic function, optical component in the form of a pair of laterally adjustable plates having shaped surfaces, and optical systems including such components |
US3617116A (en) | 1969-01-29 | 1971-11-02 | American Optical Corp | Method for producing a unitary composite ophthalmic lens |
US3632696A (en) | 1969-03-28 | 1972-01-04 | American Optical Corp | Method for making integral ophthalmic lens |
US3673616A (en) | 1970-01-16 | 1972-07-04 | Svyatoslav Nikolaevich Fedorov | Artificial anterior chamber lens |
FR2097216A5 (en) | 1970-05-27 | 1972-03-03 | Anvar | |
US3673816A (en) | 1971-03-05 | 1972-07-04 | Jones & Laughlin Steel Corp | Coupling arrangement |
US3827798A (en) | 1971-04-05 | 1974-08-06 | Optical Res & Dev Corp | Optical element of reduced thickness |
US4055378A (en) | 1971-12-31 | 1977-10-25 | Agfa-Gevaert Aktiengesellschaft | Silicone contact lens with hydrophilic surface treatment |
US3751138A (en) | 1972-03-16 | 1973-08-07 | Humphrey Res Ass | Variable anamorphic lens and method for constructing lens |
CA1012392A (en) | 1973-08-16 | 1977-06-21 | American Optical Corporation | Progressive power ophthalmic lens |
US3906551A (en) | 1974-02-08 | 1975-09-23 | Klaas Otter | Artificial intra-ocular lens system |
US3922728A (en) | 1974-08-15 | 1975-12-02 | Krasnov Mikhail M | Artificial crystalline lens |
US3913148A (en) | 1974-12-26 | 1975-10-21 | Ernst W Potthast | Intraocular lens apparatus |
US3925825A (en) | 1975-01-24 | 1975-12-16 | American Optical Corp | Supporting system for artificial intraocular lens |
US4038088A (en) | 1975-03-10 | 1977-07-26 | The Goodyear Tire & Rubber Company | Mold release agent |
US3996626A (en) | 1975-08-20 | 1976-12-14 | American Optical Corporation | Artificial intraocular lens |
US4053953A (en) | 1976-01-14 | 1977-10-18 | Leonard Flom | Posterior chamber artificial intraocular lens with retaining means and instruments for use therewith adapted to provide extraocular confirmation of operative engagement |
DE2610203B2 (en) | 1976-03-11 | 1981-01-22 | Optische Werke G. Rodenstock, 8000 Muenchen | Progressive lens |
US4056855A (en) | 1976-04-07 | 1977-11-08 | Charles Kelman | Intraocular lens and method of implanting same |
US4073014A (en) | 1976-05-28 | 1978-02-14 | Stanley Poler | Intra-ocular lens |
US4041552A (en) | 1976-09-01 | 1977-08-16 | Fotios Ganias | Artificial lens |
US4102567A (en) | 1976-09-13 | 1978-07-25 | American Optical Corporation | Material for fabrication of artificial intraocular lenses and hard contact lenses |
DE2702117A1 (en) | 1977-01-20 | 1978-07-27 | Soehnges Optik | Loose-seat contact lens - has surface structures on securing surface against corneal surface formed by moulding |
US4087866A (en) | 1977-04-26 | 1978-05-09 | Coburn Optical Industries, Inc. | Intraocular lens |
US4110848A (en) | 1977-05-06 | 1978-09-05 | Ronald P. Jensen | Intraocular lens for implantation into the posterior chamber of a human eye |
US4159546A (en) | 1977-06-15 | 1979-07-03 | Shearing Steven P | Intraocular lens |
US4162122A (en) | 1977-09-14 | 1979-07-24 | Cohen Allen L | Zonal bifocal contact lens |
US4210391A (en) | 1977-09-14 | 1980-07-01 | Cohen Allen L | Multifocal zone plate |
US4338005A (en) | 1978-12-18 | 1982-07-06 | Cohen Allen L | Multifocal phase place |
US4340283A (en) | 1978-12-18 | 1982-07-20 | Cohen Allen L | Phase shift multifocal zone plate |
US4240163A (en) | 1979-01-31 | 1980-12-23 | Galin Miles A | Medicament coated intraocular lens |
US4285072A (en) | 1979-05-14 | 1981-08-25 | Harry H. Leveen | Anterior-posterior intraocular lens |
US4274717A (en) | 1979-05-18 | 1981-06-23 | Younger Manufacturing Company | Ophthalmic progressive power lens and method of making same |
JPS5942286B2 (en) | 1979-08-24 | 1984-10-13 | セイコーエプソン株式会社 | eyeglass lenses |
US4418991A (en) | 1979-09-24 | 1983-12-06 | Breger Joseph L | Presbyopic contact lens |
US4304012A (en) | 1979-10-05 | 1981-12-08 | Iolab Corporation | Intraocular lens assembly with improved mounting to the iris |
US4298994A (en) | 1979-10-26 | 1981-11-10 | Clayman Henry M | Posterior chamber intra-ocular transplant device |
US4307945A (en) | 1980-02-14 | 1981-12-29 | Itek Corporation | Progressively varying focal power opthalmic lens |
USRE32525F1 (en) | 1980-04-01 | 1989-05-09 | Universal intraocular lens and a method of measuring an eye chamber size | |
US4366582A (en) | 1980-12-01 | 1983-01-04 | Faulkner Gerald D | Posterior chamber intraocular lens |
US4340979A (en) | 1981-03-18 | 1982-07-27 | Kelman Charles D | Intraocular lens |
US4361913A (en) | 1981-04-03 | 1982-12-07 | Streck Donald A | Intraocular lens |
GB2101764B (en) | 1981-04-29 | 1984-08-30 | Pilkington Perkin Elmer Ltd | Improvements in or relating to artificial eye lenses |
US4402579A (en) | 1981-07-29 | 1983-09-06 | Lynell Medical Technology Inc. | Contact-lens construction |
US4363143A (en) | 1981-09-09 | 1982-12-14 | Callahan Wayne B | Intraocular lens |
US4409691A (en) | 1981-11-02 | 1983-10-18 | Levy Chauncey F | Focussable intraocular lens |
US4457592A (en) | 1981-12-03 | 1984-07-03 | Polaroid Corporation | Optical system utilizing a transversely movable plate for focusing |
US5776191A (en) | 1982-02-05 | 1998-07-07 | Staar Surgical Company | Fixation system for intraocular lens structures |
US4702244A (en) | 1982-02-05 | 1987-10-27 | Staar Surgical Company | Surgical device for implantation of a deformable intraocular lens |
US4404694A (en) | 1982-03-18 | 1983-09-20 | Kelman Charles D | Intraocular lens |
US4426741A (en) | 1982-04-08 | 1984-01-24 | Ioptex Inc. | Intraocular lens with rotatable appendage |
US4435856A (en) | 1982-04-14 | 1984-03-13 | Esperance Francis A L | Bifocal intraocular lens structure and spectacle actuation frame |
US4512040A (en) | 1982-06-09 | 1985-04-23 | Mcclure Hubert L | Bifocal intraocular lens |
DE3222099C2 (en) | 1982-06-11 | 1984-06-20 | Titmus Eurocon Kontaktlinsen Gmbh & Co Kg, 8750 Aschaffenburg | Bifocal contact lens of the bivisual type |
GB2124500B (en) | 1982-07-22 | 1986-04-30 | Mazzocco Thomas R | Improved fixation system for intraocularers structures |
US4888015A (en) | 1982-08-20 | 1989-12-19 | Domino Rudolph S | Method of replacing an eye lens |
US4476591A (en) | 1982-10-07 | 1984-10-16 | Arnott Eric J | Lens implants for insertion in the human eye |
GB2129155B (en) | 1982-10-13 | 1987-05-20 | Ng Trustees & Nominees Ltd | Bifocal contact lenses |
US4463458A (en) | 1982-11-08 | 1984-08-07 | Vision Laboratories Inc. | Intraocular lens and implantation method |
DE3246306A1 (en) | 1982-12-14 | 1984-06-14 | Titmus Eurocon Kontaktlinsen Gmbh & Co Kg, 8750 Aschaffenburg | Bifocal lens of bivisual type |
US4580882A (en) | 1983-04-21 | 1986-04-08 | Benjamin Nuchman | Continuously variable contact lens |
US4617023A (en) | 1983-05-02 | 1986-10-14 | Peyman Gholam A | Intraocular lenses with openable haptic loops |
EP0150174A4 (en) | 1983-05-13 | 1986-12-08 | Chauncey F Levy | Focussable intraocular lens. |
US4474751A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
US4474753A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Topical drug delivery system utilizing thermosetting gels |
US4474752A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
FR2546057A1 (en) | 1983-05-16 | 1984-11-23 | Aron Rosa Daniele | EYE IMPLANT |
US4478822A (en) | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
US4608050A (en) | 1983-07-21 | 1986-08-26 | Innovative Surgical Products, Inc. | Correction of defects in the eye and compositions therefor |
US4542542A (en) | 1983-07-21 | 1985-09-24 | Innovative Surgical Products, Inc. | Correction of defects in the eye and compositions therefor |
US4618229A (en) | 1983-07-22 | 1986-10-21 | Bausch & Lomb Incorporated | Bifocal contact lens |
US4575877A (en) | 1983-08-04 | 1986-03-18 | Herrick Robert S | Intraocular lens having loops defining a posterior capsule barrier |
US4551864A (en) | 1983-08-18 | 1985-11-12 | Iolab Corporation | Anterior chamber lens |
US4664666A (en) | 1983-08-30 | 1987-05-12 | Ezekiel Nominees Pty. Ltd. | Intraocular lens implants |
GB2146791B (en) | 1983-09-16 | 1987-01-28 | Suwa Seikosha Kk | Progressive multifocal ophthalmic lens |
US4560383A (en) | 1983-10-27 | 1985-12-24 | Leiske Larry G | Anterior chamber intraocular lens |
US4687484A (en) | 1983-12-12 | 1987-08-18 | Kaplan Linda J | Anterior chamber intraocular lens |
US4650292A (en) | 1983-12-28 | 1987-03-17 | Polaroid Corporation | Analytic function optical component |
US4615701A (en) | 1984-01-03 | 1986-10-07 | Woods Randall L | Intraocular lens and method of implantation thereof |
US4596578A (en) | 1984-01-30 | 1986-06-24 | Kelman Charles D | Intraocular lens with miniature optic |
EP0162573A3 (en) | 1984-04-17 | 1986-10-15 | Sanford D. Hecht | Eye implant |
US4601545A (en) | 1984-05-16 | 1986-07-22 | Kern Seymour P | Variable power lens system |
US4676793A (en) | 1984-05-17 | 1987-06-30 | Bechert Ii Charles H | Intraocular lens |
US4878911A (en) | 1984-06-25 | 1989-11-07 | Anis Aziz Y | Flexible one-piece posterior chamber lens |
US4629460A (en) | 1984-06-25 | 1986-12-16 | Dyer Robert L | Intraocular lens |
NL8500527A (en) | 1984-06-25 | 1986-01-16 | Aziz Yehia Anis | FLEXIBLE LENS FOR THE REAR EYE CHAMBER. |
US4576607A (en) | 1984-07-13 | 1986-03-18 | Kelman Charles D | Intraocular lenses |
US4693716A (en) | 1984-08-21 | 1987-09-15 | Mackool Richard J | Multipartite intraocular lens |
EP0176272B1 (en) | 1984-09-07 | 1989-10-25 | Nippon Steel Corporation | Shape memory alloy and method for producing the same |
US4976732A (en) | 1984-09-12 | 1990-12-11 | International Financial Associates Holdings, Inc. | Optical lens for the human eye |
US4624669A (en) | 1984-09-26 | 1986-11-25 | Surgidev Corporation | Corneal inlay with holes |
FI79619C (en) | 1984-12-31 | 1990-01-10 | Antti Vannas | Intraocular lens |
US4581033A (en) | 1985-01-08 | 1986-04-08 | Callahan Wayne B | Unitary intraocular lens providing four-point support |
US4759762A (en) | 1985-03-08 | 1988-07-26 | Grendahl Dennis T | Accommodating lens |
US4646720A (en) | 1985-03-12 | 1987-03-03 | Peyman Gholam A | Optical assembly permanently attached to the cornea |
US4693572A (en) | 1985-06-03 | 1987-09-15 | Fused Kontacts Of Chicago, Inc. | Monocentric bifocal corneal contact lens |
US4655770A (en) | 1985-06-06 | 1987-04-07 | Ioptex, Inc. | Surface passivated intraocular lens |
EP0227653A1 (en) | 1985-06-24 | 1987-07-08 | BRONSTEIN, Leonard | Contact lens |
US4661108A (en) | 1985-07-03 | 1987-04-28 | Surgidev Corporation | Intraocular lens |
US4787903A (en) | 1985-07-24 | 1988-11-29 | Grendahl Dennis T | Intraocular lens |
US4961746A (en) | 1985-08-23 | 1990-10-09 | American Cyanamid Company | Intraocular lens with colored legs and method of making |
US4666444A (en) | 1985-09-13 | 1987-05-19 | Pannu Jaswant S | Easily insertable intraocular lens |
US4737322A (en) | 1985-09-27 | 1988-04-12 | Staar Surgical Company | Intraocular lens structure with polyimide haptic portion and methods for fabrication |
US4666445A (en) | 1985-10-01 | 1987-05-19 | Tillay Michael J | Intraocular lens with shape memory alloy haptic/optic and method of use |
US4752123A (en) | 1985-11-19 | 1988-06-21 | University Optical Products Co. | Concentric bifocal contact lens with two distance power regions |
US4662882A (en) | 1985-11-21 | 1987-05-05 | Hoffer Kenneth J | Intraocular lens |
US4636210A (en) | 1985-12-09 | 1987-01-13 | Hoffer Kenneth J | Multi-part intraocular lens and method of implanting it in an eye |
US4808170A (en) | 1985-12-16 | 1989-02-28 | Alcon Laboratories, Inc. | Hypotraumatic injection needle useful in ophthalmic surgery |
US4648878A (en) | 1985-12-23 | 1987-03-10 | Kelman Charles D | Posterior chamber lens implant |
GB2192291B (en) | 1986-03-04 | 1990-08-22 | Gupta Anil K | Progressive power contact lens. |
GB8606821D0 (en) * | 1986-03-19 | 1986-04-23 | Pa Consulting Services | Corneal reprofiling |
US4840627A (en) | 1986-04-08 | 1989-06-20 | Michael Blumenthal | Artificial eye lens and method of transplanting same |
US4711638A (en) | 1986-05-12 | 1987-12-08 | Lindstrom Richard L | Intraocular lens |
US4725277A (en) | 1986-05-14 | 1988-02-16 | Precision-Cosmet Co., Inc. | Intraocular lens with tapered haptics |
EP0248489A3 (en) | 1986-06-02 | 1989-09-06 | Gregory N. Miller | Contact lens and method of making same |
WO1987007496A1 (en) | 1986-06-05 | 1987-12-17 | Precision-Cosmet Co., Inc. | One-piece bifocal intraocular lens construction |
US4710193A (en) | 1986-08-18 | 1987-12-01 | David Volk | Accommodating intraocular lens and lens series and method of lens selection |
US4676792A (en) | 1986-08-26 | 1987-06-30 | Donald Praeger | Method and artificial intraocular lens device for the phakic treatment of myopia |
US4710194A (en) | 1986-10-20 | 1987-12-01 | Kelman Charles D | Intraocular lens with optic of expandable hydrophilic material |
GB2197663B (en) | 1986-11-21 | 1990-07-11 | Manganese Bronze Ltd | High density sintered ferrous alloys |
US5236970A (en) | 1987-02-05 | 1993-08-17 | Allergan, Inc. | Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses |
US4885105A (en) | 1987-05-14 | 1989-12-05 | The Clorox Company | Films from PVA modified with nonhydrolyzable anionic comonomers |
US4883485A (en) | 1987-05-15 | 1989-11-28 | Patel Jayant K | Expandable lens replacement |
US4842601A (en) | 1987-05-18 | 1989-06-27 | Smith S Gregory | Accommodating intraocular lens and method of implanting and using same |
US5201762A (en) | 1987-05-20 | 1993-04-13 | Hauber Frederick A | Intraocular archromatic lens |
US4790847A (en) | 1987-05-26 | 1988-12-13 | Woods Randall L | Intraocular lens implant having eye focusing capabilities |
US5166711A (en) | 1987-06-01 | 1992-11-24 | Valdemar Portney | Multifocal ophthalmic lens |
US5166712A (en) | 1987-06-01 | 1992-11-24 | Valdemar Portney | Multifocal ophthalmic lens |
US5225858A (en) | 1987-06-01 | 1993-07-06 | Valdemar Portney | Multifocal ophthalmic lens |
US5270744A (en) | 1987-06-01 | 1993-12-14 | Valdemar Portney | Multifocal ophthalmic lens |
US4769035A (en) | 1987-06-02 | 1988-09-06 | Kelman Charles D | Artificial lens and the method for implanting such lens |
US5074877A (en) | 1987-07-02 | 1991-12-24 | Nordan Lee T | Intraocular multifocal lens |
US5019099A (en) | 1987-07-02 | 1991-05-28 | Nordan Lee T | Intraocular multifocal lens method for correcting the aphakic eye |
US4917681A (en) | 1987-08-24 | 1990-04-17 | Nordan Lee T | Intraocular multifocal lens |
US4769033A (en) | 1987-07-02 | 1988-09-06 | Nordan Lee T | Intraocular multifocal lens |
US5236452A (en) | 1987-07-02 | 1993-08-17 | Nordan Lee T | Intraocular multifocal lens |
US4932968A (en) | 1987-07-07 | 1990-06-12 | Caldwell Delmar R | Intraocular prostheses |
US4865601A (en) | 1987-07-07 | 1989-09-12 | Caldwell Delmar R | Intraocular prostheses |
US4816030A (en) | 1987-07-13 | 1989-03-28 | Robinson Paul J | Intraocular lens |
US4828558A (en) | 1987-07-28 | 1989-05-09 | Kelman Charles D | Laminate optic with interior Fresnel lens |
US4921496A (en) | 1987-08-24 | 1990-05-01 | Grendahl Dennis T | Radially segemented zone of focus artificial hydrogel lens |
US4919663A (en) | 1987-08-24 | 1990-04-24 | Grendahl Dennis T | Laminated zone of focus artificial hydrogel lens |
US5158572A (en) | 1987-09-10 | 1992-10-27 | Nielsen James Mchenry | Multifocal intraocular lens |
EP0308077A3 (en) | 1987-09-14 | 1990-05-30 | Nestle S.A. | Synthetic intracorneal lens |
US4834750A (en) | 1987-09-17 | 1989-05-30 | Ioptex Research, Inc. | Deformable-elastic intraocular lens |
US5047052A (en) | 1987-11-06 | 1991-09-10 | Seymour Dubroff | Anterior chamber intraocular lens with four point fixation |
US5056908A (en) | 1987-11-12 | 1991-10-15 | Cohen Allen L | Optic zone phase channels |
US4881804A (en) | 1987-11-12 | 1989-11-21 | Cohen Allen L | Multifocal phase plate with a pure refractive portion |
US5054905A (en) | 1987-11-12 | 1991-10-08 | Cohen Allen L | Progressive intensity phase bifocal |
US4881805A (en) | 1987-11-12 | 1989-11-21 | Cohen Allen L | Progressive intensity phase bifocal |
US4834749A (en) | 1987-12-24 | 1989-05-30 | Texceed Corporation | Haptic attachment method and assembly |
US4888012A (en) | 1988-01-14 | 1989-12-19 | Gerald Horn | Intraocular lens assemblies |
GB2215076A (en) | 1988-02-02 | 1989-09-13 | Dennis T Grendahl | Intraocular lens having a hard optic and a soft skirt |
EP0336877B1 (en) | 1988-02-08 | 1993-10-27 | Wesley K. Herman | Intraocular lens |
US4888016A (en) | 1988-02-10 | 1989-12-19 | Langerman David W | "Spare parts" for use in ophthalmic surgical procedures |
IT1215851B (en) | 1988-02-11 | 1990-02-22 | Renato Liffredo | INTRAOCULAR LENS WITH CHROMATIC CORRECTION AND ABSORPTION DIAGRAM. |
EP0328117B1 (en) | 1988-02-12 | 1994-12-28 | Menicon Co., Ltd. | Processes for production of a Baloon for an intraocular lens |
JPH027954A (en) | 1988-03-04 | 1990-01-11 | Alcon Surgical Inc | Manufacture of lens with colored periphery |
US4822360A (en) | 1988-03-16 | 1989-04-18 | University Of Utah | Inflatable, intraocular lens and method of implanting the lens in the capsule of an eye |
IL85860A (en) | 1988-03-24 | 1992-06-21 | Amir Cohen | Contact lens |
CA1316728C (en) | 1988-04-01 | 1993-04-27 | Michael J. Simpson | Multi-focal diffractive ophthalmic lenses |
US4929289A (en) | 1988-04-05 | 1990-05-29 | Nkk Corporation | Iron-based shape-memory alloy excellent in shape-memory property and corrosion resistance |
CS271606B1 (en) | 1988-04-11 | 1990-10-12 | Sulc Jiri | Intraocular optical system |
FR2631228B1 (en) | 1988-05-11 | 1990-08-10 | Domilens Laboratoires | INTRA-EYE IMPLANT OF PREVIOUS CHAMBER |
US4932970A (en) | 1988-05-17 | 1990-06-12 | Allergan, Inc. | Ophthalmic lens |
IT1217703B (en) | 1988-05-24 | 1990-03-30 | Mario Giovanzana | MULTIFOCAL CONTACT LENS WITH PROGRESSIVE ECCENTRICITY AND PROCEDURE FOR ITS MANUFACTURE |
WO1989011872A1 (en) | 1988-06-09 | 1989-12-14 | Alza Corporation | Permeation enhancer comprising ethanol and glycerol monooleate |
US4878910A (en) | 1988-06-13 | 1989-11-07 | Koziol Jeffrey E | Intraocular lens assembly |
US4898416A (en) | 1988-07-05 | 1990-02-06 | Hughes Aircraft Company | Pickup device |
US4923296A (en) | 1988-07-14 | 1990-05-08 | Erickson Paul M | Oriented simultaneous vision bifocal contact lenses or the like utilizing introaocular suppression of blur |
ES2081811T3 (en) | 1988-07-20 | 1996-03-16 | Allen L Dr Cohen | MULTIFOCAL DIFRACTIVE OPTICAL ELEMENT. |
US5139519A (en) | 1988-07-26 | 1992-08-18 | Kalb Irvin M | Multi-focal intra-ocular lens |
US4830481A (en) | 1988-08-12 | 1989-05-16 | Minnesota Mining And Manufacturing Company | Multifocal diffractive lens |
US4932966A (en) | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US4888014A (en) | 1988-09-13 | 1989-12-19 | Allergan, Inc. | Endocapsular intraocular lens |
JP2718961B2 (en) | 1988-11-04 | 1998-02-25 | 株式会社メニコン | Intraocular lens |
FR2642854B1 (en) | 1989-02-03 | 1991-05-03 | Essilor Int | OPTICAL LENS WITH SIMULTANEOUS VISION FOR PRESBYTIA CORRECTION |
US5002571A (en) | 1989-02-06 | 1991-03-26 | Donnell Jr Francis E O | Intraocular lens implant and method of locating and adhering within the posterior chamber |
US4902293A (en) | 1989-04-13 | 1990-02-20 | Feaster Fred T | Intraocular lens with inflatable haptic |
US4946469A (en) | 1989-04-20 | 1990-08-07 | Faezeh Sarfarazi | Intraocular lens |
US5358520A (en) | 1989-04-28 | 1994-10-25 | Nestle S.A. | Supplementary intraocular lens system |
US4997442A (en) | 1989-05-04 | 1991-03-05 | Alcon Laboratories, Inc. | Bicomposite intraocular lenses |
FR2647227B1 (en) | 1989-05-19 | 1991-08-23 | Essilor Int | OPTICAL COMPONENT, SUCH AS AN INTRAOCULAR IMPLANT OR CONTACT LENS, SUITABLE FOR CORRECTING THE VISION OF AN INDIVIDUAL |
US4932971A (en) | 1989-06-05 | 1990-06-12 | Kelman Charles D | Clip-on optic assembly |
US4923468A (en) | 1989-06-13 | 1990-05-08 | Wild Victor F | Intraocular lens with fluorescing support loops |
WO1991003361A1 (en) | 1989-08-31 | 1991-03-21 | American Industrial Machine Co., Inc. | Method and apparatus for cleaning used bricks |
US5171267A (en) | 1989-08-31 | 1992-12-15 | The Board Of Regents Of The University Of Washington | Surface-modified self-passivating intraocular lenses |
EP0420549A3 (en) | 1989-09-25 | 1991-06-12 | Kingston Technologies, Inc. | Corneal lens implant |
US4995880A (en) | 1989-09-26 | 1991-02-26 | Galib Samuel H | Intraocular lens and method of surgically implanting same in an eye |
US4955902A (en) | 1989-11-13 | 1990-09-11 | Kelman Charles D | Decentered intraocular lens |
AU6978991A (en) | 1989-12-07 | 1991-07-18 | Leonard Seidner | Corneal contact lenses |
US5152788A (en) | 1989-12-27 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lens and method of manufacture |
WO1995003783A1 (en) | 1990-03-06 | 1995-02-09 | Houston Biotechnology Incorporated | Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract |
US5133748A (en) | 1990-03-16 | 1992-07-28 | Feaster Fred T | Intraocular lens fixated to the capsular membrane or iris with adhesive |
US5078740A (en) | 1990-04-02 | 1992-01-07 | Walman Gerald B | Intraocular lens |
GB9008582D0 (en) | 1990-04-17 | 1990-06-13 | Pilkington Diffractive Lenses | Method and contact lenses for treating presbyobia |
GB9008577D0 (en) | 1990-04-17 | 1990-06-13 | Pilkington Diffractive Lenses | Rigid gas permeable lenses |
US5047051A (en) | 1990-04-27 | 1991-09-10 | Cumming J Stuart | Intraocular lens with haptic anchor plate |
US5026396A (en) | 1990-05-07 | 1991-06-25 | Darin John J | Two-piece intraocular lens |
US5074942A (en) | 1990-05-15 | 1991-12-24 | Texceed Corporation | Method for making intraocular lens with integral colored haptics |
JPH0431836A (en) | 1990-05-28 | 1992-02-04 | Sony Corp | Ocular cap for camera |
US5476445A (en) | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5147397A (en) | 1990-07-03 | 1992-09-15 | Allergan, Inc. | Intraocular lens and method for making same |
US5117306A (en) | 1990-07-17 | 1992-05-26 | Cohen Allen L | Diffraction bifocal with adjusted chromaticity |
US5229797A (en) | 1990-08-08 | 1993-07-20 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lenses |
US5203788A (en) | 1991-03-14 | 1993-04-20 | Wiley Robert G | Micromotor actuated adjustable focus lens |
US5171266A (en) | 1990-09-04 | 1992-12-15 | Wiley Robert G | Variable power intraocular lens with astigmatism correction |
US5108429A (en) | 1991-03-11 | 1992-04-28 | Wiley Robert G | Micromotor actuated adjustable focus lens |
FR2666504B1 (en) | 1990-09-11 | 1997-11-28 | Daniel Guerin | INTRAOCULAR ARTIFICIAL LENS. |
FR2666735A1 (en) | 1990-09-13 | 1992-03-20 | Klw | Intraocular implant with internal cavity |
DE4030899A1 (en) | 1990-09-29 | 1992-04-09 | Ipp Intellectual Property Prot | DEVICE FOR POSITIONING AN INTRAOCULAR LENS |
US5173723A (en) | 1990-10-02 | 1992-12-22 | Volk Donald A | Aspheric ophthalmic accommodating lens design for intraocular lens and contact lens |
US5066301A (en) | 1990-10-09 | 1991-11-19 | Wiley Robert G | Variable focus lens |
US5112351A (en) | 1990-10-12 | 1992-05-12 | Ioptex Research Inc. | Multifocal intraocular lenses |
US5260727A (en) | 1990-10-22 | 1993-11-09 | Oksman Henry C | Wide depth of focus intraocular and contact lenses |
FR2668362B1 (en) | 1990-10-31 | 1997-12-05 | Corneal Ind | MULTIFOCAL LENS AND IN PARTICULAR BIFOCAL INTRAOCULAR IMPLANT WITH ALTERNATED AND PRIVILEGED VISION CORRECTION AREAS. |
US5258025A (en) | 1990-11-21 | 1993-11-02 | Fedorov Svjatoslav N | Corrective intraocular lens |
DE4038088C2 (en) | 1990-11-29 | 1994-05-19 | Klaas Dieter | Artificial eye lens implant |
JP2540879Y2 (en) | 1990-11-30 | 1997-07-09 | 株式会社メニコン | Intraocular lens |
RU2014038C1 (en) | 1990-12-13 | 1994-06-15 | Виктор Викторович Курилов | Method of varying refraction of eye optic system with implanted artificial lens and artificial lens |
RU2014039C1 (en) | 1990-12-13 | 1994-06-15 | Виктор Викторович Курилов | Method of varying focal power of artificial lens and artificial lens |
JP3086263B2 (en) | 1990-12-25 | 2000-09-11 | 株式会社メニコン | Intraocular lens forming body |
US5217491A (en) | 1990-12-27 | 1993-06-08 | American Cyanamid Company | Composite intraocular lens |
CH681687A5 (en) | 1991-03-07 | 1993-05-14 | Helmut Dr Med Payer | Artificial lens for human eye - comprises elastically deformable lens body surrounded by elastically deformable force transmission part |
DE69220596T2 (en) | 1991-04-04 | 1998-02-05 | Menicon Co Ltd | Device for preventing secondary cataracts |
US5133749A (en) | 1991-05-13 | 1992-07-28 | Nordan Lee T | Centrating haptics |
US5152789A (en) | 1991-05-14 | 1992-10-06 | Allergan, Inc. | Fixation member for an intraocular lens |
US5766244A (en) | 1991-05-23 | 1998-06-16 | Binder; Helmut | Intraocular artificial lens and method for fabricating same |
US5180390A (en) | 1991-07-30 | 1993-01-19 | Drews Robert C | Intraocular lens with reinforcing element |
WO1993002639A1 (en) | 1991-08-06 | 1993-02-18 | Autogenesis Technologies, Inc. | Injectable collagen-based compositions for making intraocular lens |
US5326347A (en) | 1991-08-12 | 1994-07-05 | Cumming J Stuart | Intraocular implants |
SG81873A1 (en) | 1991-08-16 | 2001-07-24 | Miles A Galin | Medicament coated refractive anterior chamber ocular implant |
US5196026A (en) | 1991-09-16 | 1993-03-23 | Chiron Ophthalmics, Inc. | Method of implanting corneal inlay lenses smaller than the optic zone |
FR2681524B1 (en) | 1991-09-25 | 1997-04-04 | Mnao | CRYSTALLINE IMPLANT. |
US5786883A (en) | 1991-11-12 | 1998-07-28 | Pilkington Barnes Hind, Inc. | Annular mask contact lenses |
US5578081A (en) | 1991-11-12 | 1996-11-26 | Henry H. McDonald | Eye muscle responsive artificial lens unit |
US6423094B1 (en) | 1991-11-18 | 2002-07-23 | Faezeh M. Sarfarazi | Accommodative lens formed from sheet material |
US5141507A (en) | 1991-12-06 | 1992-08-25 | Iolab Corporation | Soft intraocular lens |
US5172723A (en) | 1991-12-31 | 1992-12-22 | Sturgis Malcolm B | Quick-connect coupling |
US5344448A (en) | 1992-02-11 | 1994-09-06 | Schneider Richard T | Multi-focal intra-ocular implant |
NL9200400A (en) | 1992-03-04 | 1993-10-01 | Jose Jorge Pavlotzky Handelend | BIFOCAL CONTACT LENS, AND METHOD FOR MANUFACTURING SUCH CONTACT LENSES |
US5197981A (en) | 1992-04-23 | 1993-03-30 | Alcon Surgical, Inc. | Intraocular lens having haptic of specific curvature and proportion |
US5354331A (en) | 1992-07-15 | 1994-10-11 | Schachar Ronald A | Treatment of presbyopia and other eye disorders |
US5443506A (en) | 1992-11-18 | 1995-08-22 | Garabet; Antoine L. | Lens with variable optical properties |
US5300115A (en) | 1992-11-19 | 1994-04-05 | Keratos, Inc. | Intraocular prosthesis |
US5448312A (en) | 1992-12-09 | 1995-09-05 | Johnson & Johnson Vision Products, Inc. | Pupil-tuned multifocal ophthalmic lens |
NZ250359A (en) | 1992-12-09 | 1996-07-26 | Johnson & Johnson Vision Prod | Multifocal ophthalmic lens pair |
US5760871A (en) | 1993-01-06 | 1998-06-02 | Holo-Or Ltd. | Diffractive multi-focal lens |
US5375611A (en) | 1993-01-26 | 1994-12-27 | Pharmacia Ab | Method for preventing secondary cataract |
US5354335A (en) | 1993-02-04 | 1994-10-11 | Isaac Lipshitz | Intraocular insert for implantation in the human eye |
US6322589B1 (en) | 1995-10-06 | 2001-11-27 | J. Stuart Cumming | Intraocular lenses with fixated haptics |
US6090141A (en) | 1993-03-05 | 2000-07-18 | Lindstrom; Richard L. | Small intracorneal lens |
IL109375A0 (en) | 1993-04-26 | 1994-07-31 | Ciba Geigy Ag | Multifocal contact lens |
US5895422A (en) | 1993-06-17 | 1999-04-20 | Hauber; Frederick A. | Mixed optics intraocular achromatic lens |
US5405386A (en) | 1993-07-09 | 1995-04-11 | Kabi Pharmacia Ophthalmics, Inc. | Intraocular lens with improved cylindrical haptic |
JP3379717B2 (en) | 1993-07-15 | 2003-02-24 | キヤノンスター株式会社 | Deformable intraocular lens |
ATE411785T1 (en) | 1993-08-27 | 2008-11-15 | Nice Trust A Trust Of The Isle | ACCOMMODATION INTRAOCULAR LENS |
US5489301A (en) | 1993-09-03 | 1996-02-06 | Barber; John C. | Corneal prosthesis |
US5423929A (en) | 1993-10-27 | 1995-06-13 | Allergan, Inc. | Intraocular lenses and methods for producing same |
DE4340205C1 (en) | 1993-11-25 | 1995-04-20 | Dieter W Klaas | Intraocular lens with accommodation device |
US5445637A (en) | 1993-12-06 | 1995-08-29 | American Cyanamid Company | Method and apparatus for preventing posterior capsular opacification |
DE4403326C1 (en) | 1994-02-03 | 1995-06-22 | Hans Reinhard Prof Dr Koch | Intraocular lens arrangement for astigmatism correction |
JP3474627B2 (en) | 1994-02-16 | 2003-12-08 | Hoya株式会社 | Intraocular lens |
EP0861056A2 (en) | 1994-04-19 | 1998-09-02 | Staar Surgical, AG | Artificial lens insertible between the iris and the natural lens of the eye |
JP3745394B2 (en) | 1994-07-04 | 2006-02-15 | 武敏 鈴木 | Intraocular lens |
FR2723691B1 (en) | 1994-08-22 | 1997-01-24 | Philippe Crozafon | INTRAOCULAR IMPLANT |
KR100809497B1 (en) | 1994-10-06 | 2008-11-21 | 스타 서지컬 컴퍼니 | Intraocular Contact Lens and Its Insertion Method |
IL111713A (en) | 1994-11-21 | 2002-02-10 | Israel Henry M | Intraocular lens assembly |
US5549760A (en) | 1994-12-01 | 1996-08-27 | White Consolidated Industries, Inc. | Mounting device for dishwasher insulation |
US6358280B1 (en) | 1994-12-08 | 2002-03-19 | Herrick Family Limited Partnership A California Limited Partnership | Artificial lens including a lens system having eccentric axes for use in an eye having an enlarged pupil |
US5574518A (en) | 1995-01-10 | 1996-11-12 | Les Laboratoires Opti-Centre Inc. | System incorporation two different sphero-non-spherical contact lenses for correcting presbytia |
DE19501444A1 (en) * | 1995-01-19 | 1996-07-25 | Morcher Gmbh | Intra ocular two lens system |
JP3662256B2 (en) | 1995-02-15 | 2005-06-22 | カミング,ジェイ・スチュワート | Perspective accommodation type intraocular lens having a T-shaped coupling portion |
US5695509A (en) | 1995-03-10 | 1997-12-09 | El Hage; Sami G. | Aspherical optical molds for continuous reshaping the cornea based on topographical analysis |
US5628795A (en) | 1995-03-15 | 1997-05-13 | Langerman David W | Spare parts for use in ophthalmic surgical procedures |
IL118064A0 (en) | 1995-05-04 | 1996-08-04 | Johnson & Johnson Vision Prod | Concentric annular ring lens designs for astigmatic presbyopes |
US5684560A (en) | 1995-05-04 | 1997-11-04 | Johnson & Johnson Vision Products, Inc. | Concentric ring single vision lens designs |
US5929969A (en) | 1995-05-04 | 1999-07-27 | Johnson & Johnson Vision Products, Inc. | Multifocal ophthalmic lens |
US5682223A (en) | 1995-05-04 | 1997-10-28 | Johnson & Johnson Vision Products, Inc. | Multifocal lens designs with intermediate optical powers |
US5652638A (en) | 1995-05-04 | 1997-07-29 | Johnson & Johnson Vision Products, Inc. | Concentric annular ring lens designs for astigmatism |
US5650837A (en) | 1995-05-04 | 1997-07-22 | Johnson & Johnson Vision Products, Inc. | Rotationally stable contact lens designs |
US5693094A (en) | 1995-05-09 | 1997-12-02 | Allergan | IOL for reducing secondary opacification |
US5774274A (en) | 1995-05-12 | 1998-06-30 | Schachar; Ronald A. | Variable focus lens by small changes of the equatorial lens diameter |
US6721104B2 (en) | 1995-05-12 | 2004-04-13 | Pc Lens Corp | System and method for focusing an elastically deformable lens |
RU2074673C1 (en) | 1995-06-01 | 1997-03-10 | Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Elastic artificial crystalline lens and method for manufacturing same |
FR2735680B1 (en) | 1995-06-22 | 1998-01-02 | W K Et Associes | INTRAOCULAR IMPLANT DEVICE FOR CORRECTING OCULAR ANISOTROPY |
US5608471A (en) | 1995-07-03 | 1997-03-04 | Westcon Contact Lens Co., Inc. | Soft, bifocal contact lens |
US5800530A (en) | 1995-08-18 | 1998-09-01 | Rizzo, Iii; Joseph | Intra-ocular lens system including microelectric components |
US5968094A (en) | 1995-09-18 | 1999-10-19 | Emmetropia, Inc. | Compound intraocular lens |
IL123857A0 (en) | 1995-09-29 | 1998-10-30 | Dunn Stephen A | Contact lens and process for fitting |
WO1997012564A1 (en) | 1995-10-06 | 1997-04-10 | Cumming J Stuart | Intraocular lenses with fixated haptics |
US5770125A (en) | 1995-11-27 | 1998-06-23 | Mentor Corporation | Haptic attachment system for intraocular lenses using diode laser |
US5716403A (en) | 1995-12-06 | 1998-02-10 | Alcon Laboratories, Inc. | Single piece foldable intraocular lens |
DE69526586T2 (en) | 1995-12-15 | 2002-11-14 | David W Langerman | Lens capsule spreader |
US5835192A (en) | 1995-12-21 | 1998-11-10 | Johnson & Johnson Vision Products, Inc. | Contact lenses and method of fitting contact lenses |
US5984962A (en) | 1996-01-22 | 1999-11-16 | Quantum Vision, Inc. | Adjustable intraocular lens |
US5728155A (en) | 1996-01-22 | 1998-03-17 | Quantum Solutions, Inc. | Adjustable intraocular lens |
US5702440A (en) | 1996-01-26 | 1997-12-30 | Allergan | Multifocal ophthalmic lens for dim-lighting conditions |
JP2000503867A (en) | 1996-01-26 | 2000-04-04 | ビジョン・ファーマシューティカルズ・リミテッド・パートナーシップ | Primary and auxiliary intraocular lens systems |
JP2001502605A (en) | 1996-01-30 | 2001-02-27 | メドトロニック,インコーポレーテッド | Articles and methods for making a stent |
IT1282072B1 (en) | 1996-02-02 | 1998-03-09 | Soleko S P A | INTRAOCULAR LENS |
FR2744908B1 (en) | 1996-02-20 | 1998-06-12 | W K Et Associes | MYOPIC INTRAOCULAR IMPLANT |
US5628797A (en) | 1996-02-23 | 1997-05-13 | Richer; Homer E. | Cosmetic anterior chamber, intraocular lens and implantation method |
FR2745711B1 (en) | 1996-03-05 | 1998-05-07 | Ioltechnologie Production | FLEXIBLE IMPLANT FORMING INTRAOCULAR LENS FOR POSTERIOR CHAMBER |
US5800533A (en) | 1996-03-18 | 1998-09-01 | Harry C. Eggleston | Adjustable intraocular lens implant with magnetic adjustment facilities |
JP2991655B2 (en) | 1996-03-19 | 1999-12-20 | ホーヤ株式会社 | Intraocular lens and manufacturing method thereof |
AU2710197A (en) | 1996-05-17 | 1997-12-09 | Helmut Payer | An ocular implant |
US5864378A (en) | 1996-05-21 | 1999-01-26 | Allergan | Enhanced monofocal IOL or contact lens |
JPH10211A (en) | 1996-06-18 | 1998-01-06 | Okifumi Nishi | Intraocular lens |
WO1998005273A1 (en) | 1996-08-06 | 1998-02-12 | Chiron Vision Corporation | Foldable intraocular lens |
FR2754444B1 (en) | 1996-10-10 | 1999-07-02 | W K Et Associes | INTRAOCULAR IMPLANT WITH FLEXIBLE OPTICS AND A SINGLE RIGID CIRCULAR HANDLE |
US6015435A (en) | 1996-10-24 | 2000-01-18 | International Vision, Inc. | Self-centering phakic intraocular lens |
US6251312B1 (en) | 1996-10-30 | 2001-06-26 | Allergan | Production methods for intraocular lenses with high pull strength fixation members |
US5812236A (en) | 1996-11-15 | 1998-09-22 | Permeable Technologies, Inc. | Multifocal corneal contact lens pair |
FR2758282B1 (en) | 1997-01-16 | 1999-04-09 | Usinor | CYLINDER FOR A ROLLING OR CONTINUOUS CASTING INSTALLATION OF METALS |
US5769890B1 (en) * | 1997-01-16 | 2000-09-05 | Surgical Concepts Inc | Placement of second artificial lens in eye to correct for optical defects of first artificial lens in eye |
US5898473A (en) | 1997-04-25 | 1999-04-27 | Permeable Technologies, Inc. | Multifocal corneal contact lens |
US6050970A (en) | 1997-05-08 | 2000-04-18 | Pharmacia & Upjohn Company | Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye |
US5928282A (en) | 1997-06-13 | 1999-07-27 | Bausch & Lomb Surgical, Inc. | Intraocular lens |
US5928283A (en) | 1997-06-26 | 1999-07-27 | Visioncare Ltd | Telescopic device for an intraocular lens |
IL121327A (en) | 1997-07-16 | 2003-12-10 | Henry M Israel | Intraocular lens assembly |
JP3850538B2 (en) | 1997-07-19 | 2006-11-29 | 敏之 永本 | Lens capsule adhesion prevention ring |
IL121417A0 (en) | 1997-07-28 | 1998-01-04 | Israel Henry M | Intraocular ring |
DE69808482T2 (en) | 1997-08-07 | 2003-07-17 | Alcon Lab Inc | INTRA-CORNEAL DIFFRAINT LENS |
US20010018612A1 (en) | 1997-08-07 | 2001-08-30 | Carson Daniel R. | Intracorneal lens |
US6800091B2 (en) | 1997-08-20 | 2004-10-05 | Thinoptx, Inc. | Method of using a small incision lens |
US5843188A (en) | 1997-10-20 | 1998-12-01 | Henry H. McDonald | Accommodative lens implantation |
WO1999020206A1 (en) | 1997-10-22 | 1999-04-29 | Societe Medicale De Precision S.M.P. S.A. | Intraocular implant device |
NL1007349C2 (en) | 1997-10-24 | 1999-04-27 | Suyker Wilhelmus Joseph Leonardus | System for the mechanical production of anastomoses between hollow structures; as well as device and applicator for use therewith. |
US6606286B1 (en) | 1998-01-05 | 2003-08-12 | Mitburri Electric Co., Ltd | Tln signal generating apparatus used in optical disc drive and optical disc drive equipped with the apparatus, and optical disc drive equipped with amplitude adjusting apparatus for tracking error signal |
US6428572B2 (en) | 1998-01-12 | 2002-08-06 | Menicon Co., Ltd. | Intraocular ring |
US20020011167A1 (en) | 1998-01-15 | 2002-01-31 | Murray Figov | Plateless printing system |
US5814103A (en) | 1998-01-15 | 1998-09-29 | Visioncare Ltd. | Intraocular lens and telescope with mating fasteners |
US6186148B1 (en) | 1998-02-04 | 2001-02-13 | Kiyoshi Okada | Prevention of posterior capsular opacification |
TW532488U (en) | 1998-02-11 | 2003-05-11 | Euro Lens Technology S P A | A progressive multifocal contact lens suitable for compensating presbyopia |
SE9800853D0 (en) | 1998-03-16 | 1998-03-16 | Pharmacia & Upjohn Bv | Intraocular lens |
FR2778093B1 (en) | 1998-05-04 | 2000-06-16 | Khalil Hanna | INTRAOCULAR IMPLANT |
SE9801573D0 (en) | 1998-05-05 | 1998-05-05 | Pharmacia & Upjohn Bv | New IOL |
US6083261A (en) | 1998-05-28 | 2000-07-04 | Callahan; Wayne B. | Crossed haptics for intraocular lenses |
US6517577B1 (en) | 1998-05-28 | 2003-02-11 | Thinoptx, Inc. | Crossed haptics for intraocular lenses |
US6162249A (en) | 1998-05-29 | 2000-12-19 | Allergan | IOI for inhibiting cell growth and reducing glare |
US6884262B2 (en) | 1998-05-29 | 2005-04-26 | Advanced Medical Optics, Inc. | Enhanced intraocular lens for reducing glare |
US6468306B1 (en) | 1998-05-29 | 2002-10-22 | Advanced Medical Optics, Inc | IOL for inhibiting cell growth and reducing glare |
EP1103014A4 (en) | 1998-08-06 | 2006-09-06 | John B W Lett | Multifocal aspheric lens |
US6238433B1 (en) | 1998-10-05 | 2001-05-29 | Allergan Sales, Inc. | Posterior/anterior chamber intraocular lenses and methods of implantation |
SE9803481D0 (en) | 1998-10-13 | 1998-10-13 | Pharmacia & Upjohn Ab | Photocurable siloxane polymers |
FR2784575B1 (en) | 1998-10-15 | 2000-12-22 | Megaoptic Gmbh | ACCOMMODATIVE INTRAOCULAR IMPLANT |
US6228115B1 (en) | 1998-11-05 | 2001-05-08 | Bausch & Lomb Surgical, Inc. | Intraocular lenses with improved axial stability |
US6152958A (en) | 1998-12-16 | 2000-11-28 | Nordan; Lee T. | Foldable thin intraocular membrane |
US6102946A (en) | 1998-12-23 | 2000-08-15 | Anamed, Inc. | Corneal implant and method of manufacture |
US6117171A (en) | 1998-12-23 | 2000-09-12 | Skottun; Bernt Christian | Encapsulated accommodating intraocular lens |
US6450642B1 (en) | 1999-01-12 | 2002-09-17 | California Institute Of Technology | Lenses capable of post-fabrication power modification |
US20050099597A1 (en) | 2002-12-24 | 2005-05-12 | Calhoun Vision | Light adjustable multifocal lenses |
US6210005B1 (en) | 1999-02-04 | 2001-04-03 | Valdemar Portney | Multifocal ophthalmic lens with reduced halo size |
US6106554A (en) | 1999-02-25 | 2000-08-22 | Bausch & Lomb Surgical, Inc. | Intraocular lens implants for the prevention of secondary cataracts |
CA2390357A1 (en) | 1999-04-01 | 2000-10-12 | Staar Surgical Ag | Deformable intraocular lens with anchored haptics |
US6942695B1 (en) | 1999-04-05 | 2005-09-13 | Wessley-Jessen Corporation | Biomedical devices with polyimide coating |
US7662179B2 (en) | 1999-04-09 | 2010-02-16 | Sarfarazi Faezeh M | Haptics for accommodative intraocular lens system |
US6488708B2 (en) | 1999-04-09 | 2002-12-03 | Faezeh Sarfarazi | Open chamber, elliptical, accommodative intraocular lens system |
US6224628B1 (en) | 1999-04-23 | 2001-05-01 | Thinoptx, Inc. | Haptics for an intraocular lens |
US6200344B1 (en) | 1999-04-29 | 2001-03-13 | Bausch & Lomb Surgical, Inc. | Inraocular lenses |
US6406494B1 (en) | 1999-04-30 | 2002-06-18 | Allergan Sales, Inc. | Moveable intraocular lens |
AU4501500A (en) | 1999-04-30 | 2000-11-17 | Allergan Sales, Inc. | Moveable intraocular lens |
US6616692B1 (en) | 1999-04-30 | 2003-09-09 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US6790232B1 (en) | 1999-04-30 | 2004-09-14 | Advanced Medical Optics, Inc. | Multifocal phakic intraocular lens |
US20060238702A1 (en) | 1999-04-30 | 2006-10-26 | Advanced Medical Optics, Inc. | Ophthalmic lens combinations |
US6536899B1 (en) | 1999-07-14 | 2003-03-25 | Bifocon Optics Gmbh | Multifocal lens exhibiting diffractive and refractive powers |
US6685741B2 (en) | 1999-07-29 | 2004-02-03 | Bausch & Lomb Incorporated | Intraocular lenses |
FR2796834B1 (en) | 1999-07-30 | 2001-12-14 | Ioltechnologie Production | IMPLANT FORMING MULTIFOCAL INTRAOCULAR LENS |
US6451056B1 (en) | 1999-08-09 | 2002-09-17 | J. Stuart Cumming | Lens for increased depth of focus |
US6261321B1 (en) | 1999-09-01 | 2001-07-17 | Robert E. Kellan | Phakic or aphakic intraocular lens assembly |
US6241777B1 (en) | 1999-09-01 | 2001-06-05 | Robert E. Kellan | Phakic intraocular lenses |
EP1212652B1 (en) | 1999-09-03 | 2007-07-25 | de Carle, John Trevor | Bifocal lenses |
US6299641B1 (en) | 1999-09-10 | 2001-10-09 | Randall Woods | Intraocular lens implant having eye accommodating capabilities |
US6217612B1 (en) | 1999-09-10 | 2001-04-17 | Randall Woods | Intraocular lens implant having eye accommodating capabilities |
US6277146B1 (en) | 1999-09-16 | 2001-08-21 | Gholam A. Peyman | Glare-free intraocular lens and method for using the same |
US6280471B1 (en) | 1999-09-16 | 2001-08-28 | Gholam A. Peyman | Glare-free intraocular lens and method for using the same |
US6599317B1 (en) | 1999-09-17 | 2003-07-29 | Advanced Medical Optics, Inc. | Intraocular lens with a translational zone |
US6645246B1 (en) | 1999-09-17 | 2003-11-11 | Advanced Medical Optics, Inc. | Intraocular lens with surrounded lens zone |
DE19951148A1 (en) | 1999-10-12 | 2001-04-19 | Technomed Ges Fuer Med Und Med | Eyeball clamping ring for use during cataract surgery has a curved and elastic element with the ends locked together to remain as an implant to support the fiber tissue |
WO2001028144A1 (en) | 1999-10-15 | 2001-04-19 | Fujitsu Limited | Synchronizing device and synchronizing system |
FR2799952B1 (en) | 1999-10-21 | 2001-12-14 | Humanoptics Ag | INTRAOCULAR IMPLANT |
US6767363B1 (en) | 1999-11-05 | 2004-07-27 | Bausch & Lomb Surgical, Inc. | Accommodating positive and negative intraocular lens system |
FR2800596B1 (en) | 1999-11-10 | 2002-03-22 | Ioltechnologie Production | PRECRYSTALLINE INTRAOCULAR IMPLANT |
EP1227771B1 (en) | 1999-11-11 | 2007-08-01 | Angiomed GmbH & Co. Medizintechnik KG | Implant delivery device |
ATE339933T1 (en) | 1999-12-14 | 2006-10-15 | Hans-Georg Dr Rer Nat Boehm | FOCUSING INTRAOCULAR LENS |
DE19961603A1 (en) | 1999-12-21 | 2001-06-28 | Bayer Ag | Production of 2-chlorocyclopropyl-1-chlorophenyl-triazolonyl-propanol derivative, useful as microbicide, from 2-chlorocyclopropyl-2-chlorobenzyl-oxirane |
US6342073B1 (en) | 1999-12-30 | 2002-01-29 | J. Stuart Cumming | Intraocular lens for posterior vaulting |
US6478821B1 (en) | 2000-01-12 | 2002-11-12 | Advanced Medical Optics, Inc. | Iris fixated intraocular lens and method of implantation |
US6475240B1 (en) * | 2000-02-02 | 2002-11-05 | Advanced Medical Optics, Inc. | Anterior chamber intraocular lens and methods for reducing pupil ovalling |
US6428573B2 (en) | 2000-02-03 | 2002-08-06 | Howard J. Barnett | Intraocular multifocal lens construction |
FR2804860B1 (en) | 2000-02-16 | 2002-04-12 | Humanoptics Ag | ACCOMODATIVE CRYSTALLINE IMPLANT |
US20050085907A1 (en) | 2000-02-16 | 2005-04-21 | Humanoptics Ag | Intraocular implant and an artificial lens device |
US6797004B1 (en) | 2000-03-02 | 2004-09-28 | Advanced Medical Optics, Inc. | Holders for intraocular lenses |
US6551354B1 (en) | 2000-03-09 | 2003-04-22 | Advanced Medical Optics, Inc. | Accommodating intraocular lens |
US6547822B1 (en) | 2000-05-03 | 2003-04-15 | Advanced Medical Optics, Inc. | Opthalmic lens systems |
US6554859B1 (en) | 2000-05-03 | 2003-04-29 | Advanced Medical Optics, Inc. | Accommodating, reduced ADD power multifocal intraocular lenses |
US6425917B1 (en) | 2000-05-12 | 2002-07-30 | Tekia | Phakic iol film frame |
US6679605B2 (en) | 2000-05-22 | 2004-01-20 | Medennium, Inc. | Crystalline polymeric compositions for ophthalmic devices |
US6598606B2 (en) | 2000-05-24 | 2003-07-29 | Pharmacia Groningen Bv | Methods of implanting an intraocular lens |
US6730123B1 (en) | 2000-06-22 | 2004-05-04 | Proteus Vision, Llc | Adjustable intraocular lens |
US6506212B2 (en) | 2000-07-07 | 2003-01-14 | Medennium, Inc. | Anatomically compatible posterior chamber phakic refractive lenses |
US6660035B1 (en) | 2000-08-02 | 2003-12-09 | Advanced Medical Optics, Inc. | Accommodating intraocular lens with suspension structure |
US20060116765A1 (en) | 2000-08-04 | 2006-06-01 | Blake Larry W | Refractive corrective lens (RCL) |
WO2002012523A2 (en) | 2000-08-10 | 2002-02-14 | Crucell Holland B.V. | Transduction of chondrocytes using adenoviral vectors |
US6454802B1 (en) | 2000-08-21 | 2002-09-24 | Bausch & Lomb Incorporated | Intraocular lens implant for the prevention of secondary cataracts |
AU2001288926A1 (en) | 2000-09-07 | 2002-03-22 | Allergan Sales, Inc. | Intraocular lens with a posterior lens portion |
US6474814B1 (en) | 2000-09-08 | 2002-11-05 | Florida Optical Engineering, Inc | Multifocal ophthalmic lens with induced aperture |
US6666887B1 (en) | 2000-10-20 | 2003-12-23 | Thinoptx, Inc. | Deformable intraocular multi-focus lens |
US6592621B1 (en) | 2000-11-10 | 2003-07-15 | Rudolph S. Domino | Flexible intra-ocular lens of variable focus |
SE0004393D0 (en) | 2000-11-29 | 2000-11-29 | Pharmacia Groningen Bv | A device for use in eye surgery |
DE10059482B4 (en) | 2000-11-30 | 2008-12-24 | *Acri.Tec AG Gesellschaft für ophthalmologische Produkte | Capsular |
US20010044657A1 (en) | 2000-11-30 | 2001-11-22 | Kellan Robert E. | Phakic or aphakic intraocular lens assembly |
US20020072796A1 (en) | 2000-12-11 | 2002-06-13 | Hoffmann Laurent G. | Iris fixated intraocular lenses |
US6558420B2 (en) | 2000-12-12 | 2003-05-06 | Bausch & Lomb Incorporated | Durable flexible attachment components for accommodating intraocular lens |
US6813643B2 (en) | 2001-01-05 | 2004-11-02 | Digeo, Inc. | Multimedia system with selectable protocol module including MPEG logic and docsis logic sharing a single tuner |
US6464725B2 (en) | 2001-01-23 | 2002-10-15 | Bernt Christian Skotton | Two-lens adjustable intraocular lens system |
US20030078657A1 (en) | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Materials for use in accommodating intraocular lens system |
US6884261B2 (en) | 2001-01-25 | 2005-04-26 | Visiogen, Inc. | Method of preparing an intraocular lens for implantation |
EP1723934B1 (en) | 2001-01-25 | 2009-06-03 | Visiogen, Inc. | Accomodating intraocular lens system |
US7198640B2 (en) | 2001-01-25 | 2007-04-03 | Visiogen, Inc. | Accommodating intraocular lens system with separation member |
US6818158B2 (en) | 2001-01-25 | 2004-11-16 | Visiogen, Inc. | Accommodating intraocular lens system and method of making same |
US7780729B2 (en) | 2004-04-16 | 2010-08-24 | Visiogen, Inc. | Intraocular lens |
US20060184244A1 (en) | 2005-02-14 | 2006-08-17 | Nguyen Tuan A | Biasing system for intraocular lens |
US8062361B2 (en) | 2001-01-25 | 2011-11-22 | Visiogen, Inc. | Accommodating intraocular lens system with aberration-enhanced performance |
US20030078658A1 (en) | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Single-piece accomodating intraocular lens system |
US6827738B2 (en) | 2001-01-30 | 2004-12-07 | Timothy R. Willis | Refractive intraocular implant lens and method |
AUPR276601A0 (en) | 2001-01-31 | 2001-02-22 | Newman, Steve | A contact lens for refractive correction and capable of engagement with an eye either inside out or right way out |
US20020173846A1 (en) | 2001-02-01 | 2002-11-21 | Larry Blake | Two part "L"- or "S"-shaped phakic IOL |
US20040148023A1 (en) | 2001-02-15 | 2004-07-29 | Shu Stephen K. | High gain wide range accommodating intraocular lens for implant into the capsular bag |
US6818017B1 (en) | 2001-02-15 | 2004-11-16 | Stephen Shu | High gain wide range accommodating intraocular lens for implant into the capsular bag |
US20020120329A1 (en) | 2001-02-28 | 2002-08-29 | Allergan Sales, Inc. | Moveable intraocular lenses and combinations of intraocular lenses |
US7107533B2 (en) | 2001-04-09 | 2006-09-12 | International Business Machines Corporation | Electronic book with multimode I/O |
US20020151973A1 (en) | 2001-04-11 | 2002-10-17 | Sakurai Seigi Co., Ltd. | Intraocular lens |
US6638305B2 (en) | 2001-05-15 | 2003-10-28 | Advanced Medical Optics, Inc. | Monofocal intraocular lens convertible to multifocal intraocular lens |
DE10125829A1 (en) | 2001-05-26 | 2002-11-28 | Gisbert Richard | Artificial lens, for implanting into the eyeball, has a thin, transparent and biologically compatible synthetic envelope, filled with a transparent material, and fitted with radial hooks for anchoring and react to the ciliary muscles |
DE20109306U1 (en) | 2001-06-02 | 2001-08-16 | Ruempler Lars | Lens or lens system for implantation in a human eye |
US20030105522A1 (en) | 2001-06-11 | 2003-06-05 | Glazier Alan N. | Multi-focal intraocular lens |
US7118597B2 (en) | 2001-06-22 | 2006-10-10 | David Miller | Accommodating intraocular lens |
US6884263B2 (en) | 2001-07-17 | 2005-04-26 | Medennium, Inc. | Accommodative intraocular lens |
ITMI20011623A1 (en) | 2001-07-26 | 2003-01-26 | St Microelectronics Srl | DRIVING DEVICE FOR ELECTRIC MOTORS |
ATE426330T1 (en) | 2001-08-10 | 2009-04-15 | Basf Plant Science Gmbh | SUGAR AND LIPID METABOLISM REGULATORS IN PLANTS III |
DE10139027A1 (en) | 2001-08-15 | 2003-02-27 | Humanoptics Ag | Intraocular implant |
US6537283B2 (en) | 2001-08-17 | 2003-03-25 | Alcon, Inc. | Intraocular lens shipping case and injection cartridge |
IL145015A0 (en) | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
US6443985B1 (en) | 2001-08-27 | 2002-09-03 | Randall Woods | Intraocular lens implant having eye accommodating capabilities |
GB0126234D0 (en) | 2001-11-01 | 2002-01-02 | Khoury Elie | Intraocular lens implant having accommodative capabilities |
US6598971B2 (en) | 2001-11-08 | 2003-07-29 | Lc Technologies, Inc. | Method and system for accommodating pupil non-concentricity in eyetracker systems |
US7097660B2 (en) | 2001-12-10 | 2006-08-29 | Valdemar Portney | Accommodating intraocular lens |
US7037338B2 (en) | 2001-12-14 | 2006-05-02 | Toshiyuki Nagamoto | Intraocular ring assembly and artificial lens kit |
AU2002357099A1 (en) | 2001-12-21 | 2003-07-24 | Bausch And Lomb Incorporated | In-vivo adjustable intraocular lens |
JP2003190193A (en) | 2001-12-26 | 2003-07-08 | Canon Star Kk | Intraocular lens |
AU2003210533A1 (en) | 2002-01-14 | 2003-07-30 | Advanced Medical Optics, Inc. | Accommodating intraocular lens with elongated suspension structure |
US7150759B2 (en) | 2002-01-14 | 2006-12-19 | Advanced Medical Optics, Inc. | Multi-mechanistic accommodating intraocular lenses |
WO2003059208A2 (en) | 2002-01-14 | 2003-07-24 | Advanced Medical Optics, Inc. | Accommodating intraocular lens with integral capsular bag ring |
FR2835424B1 (en) | 2002-02-01 | 2004-11-26 | Khalil Hanna | ACCOMODATIVE INTRACAPSULAR IMPLANT |
US20050021139A1 (en) | 2003-02-03 | 2005-01-27 | Shadduck John H. | Ophthalmic devices, methods of use and methods of fabrication |
US20070100445A1 (en) | 2003-02-03 | 2007-05-03 | Shadduck John H | Intraocular lenses and business methods |
US7261737B2 (en) | 2002-12-12 | 2007-08-28 | Powervision, Inc. | Accommodating intraocular lens system and method |
US8048155B2 (en) | 2002-02-02 | 2011-11-01 | Powervision, Inc. | Intraocular implant devices |
US20030187505A1 (en) | 2002-03-29 | 2003-10-02 | Xiugao Liao | Accommodating intraocular lens with textured haptics |
US20030187504A1 (en) | 2002-04-01 | 2003-10-02 | Weinschenk Joseph I. | Adjustable intraocular lens |
US20040158322A1 (en) | 2002-04-17 | 2004-08-12 | Shen Jin Hui | Intraocular lens system |
US20040014049A1 (en) | 2002-07-19 | 2004-01-22 | Isis Pharmaceuticals Inc. | Antisense modulation of protein kinase C-iota expression |
AU2003274345A1 (en) | 2002-06-05 | 2003-12-22 | Sap Aktiengesellschaft | Apparatus and method for integrating variable subsidiary information with main office information in an enterprise system |
US20040002757A1 (en) | 2002-06-27 | 2004-01-01 | Bausch & Lomb Incorporated | Intraocular lens |
EP2261301A1 (en) | 2002-08-27 | 2010-12-15 | Fujifilm Corporation | Organometallic complexes, organic electroluminescent devices and organic electroluminescent displays |
US20040082993A1 (en) | 2002-10-25 | 2004-04-29 | Randall Woods | Capsular intraocular lens implant having a refractive liquid therein |
US20040082995A1 (en) | 2002-10-25 | 2004-04-29 | Randall Woods | Telescopic intraocular lens implant for treating age-related macular degeneration |
US7125422B2 (en) | 2002-10-25 | 2006-10-24 | Quest Vision Technology, Inc. | Accommodating intraocular lens implant |
US7381221B2 (en) | 2002-11-08 | 2008-06-03 | Advanced Medical Optics, Inc. | Multi-zonal monofocal intraocular lens for correcting optical aberrations |
US7896916B2 (en) | 2002-11-29 | 2011-03-01 | Amo Groningen B.V. | Multifocal ophthalmic lens |
SE0203564D0 (en) | 2002-11-29 | 2002-11-29 | Pharmacia Groningen Bv | Multifocal opthalmic lens |
US7247168B2 (en) | 2002-12-12 | 2007-07-24 | Powervision, Inc. | Accommodating intraocular lens system and method |
US7637947B2 (en) | 2002-12-12 | 2009-12-29 | Powervision, Inc. | Accommodating intraocular lens system having spherical aberration compensation and method |
US7217288B2 (en) | 2002-12-12 | 2007-05-15 | Powervision, Inc. | Accommodating intraocular lens having peripherally actuated deflectable surface and method |
US20040117013A1 (en) | 2002-12-12 | 2004-06-17 | Ira Schachar | Device and method for treating macular degeneration |
EP2559405A3 (en) | 2002-12-12 | 2013-06-26 | PowerVision, Inc. | Accommodating intraocular lens system |
US6616691B1 (en) | 2003-01-10 | 2003-09-09 | Alcon, Inc. | Accommodative intraocular lens |
US7238201B2 (en) | 2003-02-13 | 2007-07-03 | Visiogen, Inc. | Accommodating intraocular lens system with enhanced range of motion |
US7615056B2 (en) | 2003-02-14 | 2009-11-10 | Visiogen, Inc. | Method and device for compacting an intraocular lens |
US20040167621A1 (en) * | 2003-02-26 | 2004-08-26 | Peyman Gholam A. | Teledioptic lens system and method for using the same |
EP1599748A4 (en) | 2003-03-06 | 2007-10-24 | John H Shadduck | Adaptive optic lens and method of making |
US7905917B2 (en) | 2003-03-31 | 2011-03-15 | Bausch & Lomb Incorporated | Aspheric lenses and lens family |
US7056409B2 (en) | 2003-04-17 | 2006-06-06 | Nanosys, Inc. | Structures, systems and methods for joining articles and materials and uses therefor |
US7803574B2 (en) | 2003-05-05 | 2010-09-28 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US6923539B2 (en) | 2003-05-12 | 2005-08-02 | Alcon, Inc. | Aspheric lenses |
US7029497B2 (en) | 2003-05-21 | 2006-04-18 | Alcon, Inc. | Accommodative intraocular lens |
US7223288B2 (en) | 2003-05-21 | 2007-05-29 | Alcon, Inc. | Accommodative intraocular lens |
US7186266B2 (en) | 2003-06-06 | 2007-03-06 | Teledioptic Lens System, Llc | Bifocal intraocular telescope for low vision correction |
US20050038510A1 (en) | 2003-08-13 | 2005-02-17 | Valdemar Portney | Multi-piece intraocular lens assembly and method of manufacturing same |
GB0319408D0 (en) * | 2003-08-19 | 2003-09-17 | Chawdhary Satish | Intraocular device |
US20050125058A1 (en) | 2003-12-03 | 2005-06-09 | Eyeonics, Inc. | Accommodating hybrid intraocular lens |
US7553327B2 (en) | 2003-12-04 | 2009-06-30 | The Nice Trust, A Trust Of The Isle Of Man | Accommodating 360 degree sharp edge optic plate haptic lens |
US20050137703A1 (en) | 2003-12-05 | 2005-06-23 | Vanderbilt University | Accommodative intraocular lens |
US7794498B2 (en) | 2003-12-05 | 2010-09-14 | Innolene Llc | Ocular lens |
JP4842835B2 (en) | 2003-12-09 | 2011-12-21 | アボット・メディカル・オプティクス・インコーポレイテッド | Foldable intraocular lens and manufacturing method thereof |
US20050131535A1 (en) | 2003-12-15 | 2005-06-16 | Randall Woods | Intraocular lens implant having posterior bendable optic |
NL1025622C2 (en) | 2004-03-03 | 2005-09-07 | Accolens Internat B V | Two optical elements with variable optical power together forming a lens for use as an intraocular lens. |
US7632864B2 (en) | 2004-03-17 | 2009-12-15 | Hikal Ltd. | Gabapentin analogues and process thereof |
IL161706A0 (en) | 2004-04-29 | 2004-09-27 | Nulens Ltd | Intraocular lens fixation device |
DE102004025305A1 (en) | 2004-05-19 | 2005-12-08 | Humanoptics Ag | Accommodatable intraocular lens |
WO2006025726A1 (en) | 2004-09-02 | 2006-03-09 | Vu Medisch Centrum | Artificial intraocular lens |
US20070135915A1 (en) | 2004-09-17 | 2007-06-14 | Klima William L | Implantable lens device |
US20060064162A1 (en) | 2004-09-17 | 2006-03-23 | Klima William L | 333Intraocular lens device |
US7815678B2 (en) | 2004-10-13 | 2010-10-19 | Nulens Ltd. | Accommodating intraocular lens (AIOL), and AIOL assemblies including same |
US7188949B2 (en) | 2004-10-25 | 2007-03-13 | Advanced Medical Optics, Inc. | Ophthalmic lens with multiple phase plates |
EP3480650A1 (en) | 2004-10-25 | 2019-05-08 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic lens with multiple phase plates |
US7922326B2 (en) | 2005-10-25 | 2011-04-12 | Abbott Medical Optics Inc. | Ophthalmic lens with multiple phase plates |
US7455691B2 (en) | 2004-11-03 | 2008-11-25 | Biovision, Ag | Intraocular and intracorneal refractive lenses |
US8377123B2 (en) | 2004-11-10 | 2013-02-19 | Visiogen, Inc. | Method of implanting an intraocular lens |
US20060116764A1 (en) | 2004-12-01 | 2006-06-01 | Simpson Michael J | Apodized aspheric diffractive lenses |
NL1029041C1 (en) | 2005-03-09 | 2006-09-12 | Akkolens Int Bv | Improved construction of an intraocular artificial lens |
US7372646B2 (en) | 2005-03-21 | 2008-05-13 | Brett Spivey | Adjustable focus lens system |
US7338159B2 (en) | 2005-03-21 | 2008-03-04 | Brett Spivey | Adjustable focus lenses |
CA2601351A1 (en) | 2005-03-30 | 2006-10-05 | Nulens Ltd | Accommodating intraocular lens (aiol) assemblies, and discrete components therfor |
US7073906B1 (en) | 2005-05-12 | 2006-07-11 | Valdemar Portney | Aspherical diffractive ophthalmic lens |
EP1924222A1 (en) | 2005-08-05 | 2008-05-28 | Visiogen, Inc. | Accommodating diffractive intraocular lens |
US8034107B2 (en) | 2005-09-01 | 2011-10-11 | Stenger Donald C | Accommodating intraocular lens |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
US20070088433A1 (en) | 2005-10-17 | 2007-04-19 | Powervision | Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use |
US8241355B2 (en) | 2005-10-28 | 2012-08-14 | Abbott Medical Optics Inc. | Haptic for accommodating intraocular lens |
DE102005053078A1 (en) | 2005-11-04 | 2007-05-10 | Dr. Schmidt Intraocularlinsen Gmbh | intraocular lens |
US20070129803A1 (en) | 2005-12-06 | 2007-06-07 | C&C Vision International Limited | Accommodative Intraocular Lens |
US20070260309A1 (en) | 2006-05-08 | 2007-11-08 | Richardson Gary A | Accommodating intraocular lens having a recessed anterior optic |
US20070258143A1 (en) | 2006-05-08 | 2007-11-08 | Valdemar Portney | Aspheric multifocal diffractive ophthalmic lens |
US8080593B2 (en) | 2006-11-29 | 2011-12-20 | University Of Southern California | Reversible thermoresponsive adhesives for implants |
US8403984B2 (en) | 2006-11-29 | 2013-03-26 | Visiogen, Inc. | Apparatus and methods for compacting an intraocular lens |
EP2124822B1 (en) | 2006-12-22 | 2019-02-20 | AMO Groningen B.V. | Accommodating intraocular lens, lens system and frame therefor |
WO2008079671A1 (en) | 2006-12-22 | 2008-07-03 | Bausch & Lomb Incorporated | Multi-element accommodative intraocular lens |
WO2008083283A2 (en) | 2006-12-29 | 2008-07-10 | Advanced Medical Optics, Inc. | Multifocal accommodating intraocular lens |
US7713299B2 (en) | 2006-12-29 | 2010-05-11 | Abbott Medical Optics Inc. | Haptic for accommodating intraocular lens |
US20080161914A1 (en) | 2006-12-29 | 2008-07-03 | Advanced Medical Optics, Inc. | Pre-stressed haptic for accommodating intraocular lens |
US8608799B2 (en) | 2007-01-24 | 2013-12-17 | Tekia, Inc. | Umbrella-shaped accommodating artificial ocular lens (AAOL) device |
KR100807940B1 (en) | 2007-03-08 | 2008-02-28 | 박경진 | Intraocular lens |
CA2852714C (en) | 2007-08-13 | 2016-10-04 | Garth T. Webb | Inflatable intra ocular lens/lens retainer |
US8740978B2 (en) | 2007-08-27 | 2014-06-03 | Amo Regional Holdings | Intraocular lens having extended depth of focus |
US8034108B2 (en) | 2008-03-28 | 2011-10-11 | Abbott Medical Optics Inc. | Intraocular lens having a haptic that includes a cap |
US8222360B2 (en) | 2009-02-13 | 2012-07-17 | Visiogen, Inc. | Copolymers for intraocular lens systems |
-
2006
- 2006-07-10 US US11/456,521 patent/US20060238702A1/en not_active Abandoned
-
2007
- 2007-06-27 WO PCT/US2007/072275 patent/WO2008008627A2/en active Application Filing
- 2007-06-27 AU AU2007272697A patent/AU2007272697A1/en not_active Abandoned
- 2007-06-27 CA CA002661704A patent/CA2661704A1/en not_active Abandoned
- 2007-06-27 EP EP07840301A patent/EP2043558A2/en not_active Withdrawn
-
2014
- 2014-01-21 US US14/160,321 patent/US9814570B2/en not_active Expired - Fee Related
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US34988A (en) * | 1862-04-15 | Improvement in sewing-machines | ||
US1483509A (en) * | 1921-05-05 | 1924-02-12 | Franklin Optical Company | Process of making fused bifocal lenses |
US2274142A (en) * | 1940-01-15 | 1942-02-24 | Revalens Co | Multifocal ophthalmic lens |
US3227507A (en) * | 1961-08-16 | 1966-01-04 | Feinbloom William | Corneal contact lens having inner ellipsoidal surface |
US3420006A (en) * | 1964-01-27 | 1969-01-07 | Howard J Barnett | Apparatus for grinding multifocal lens |
US3431327A (en) * | 1964-08-31 | 1969-03-04 | George F Tsuetaki | Method of making a bifocal contact lens with an embedded metal weight |
US3718870A (en) * | 1971-08-12 | 1973-02-27 | Itt | Driving circuit for electro-mechanical oscillators |
US3711870A (en) * | 1971-12-07 | 1973-01-23 | R Deitrick | Artificial lens implant |
US3794414A (en) * | 1972-05-12 | 1974-02-26 | Jessen Inc Wesley | Multiple focal contact lens |
US3866249A (en) * | 1974-03-07 | 1975-02-18 | Leonard Flom | Posterior chamber artificial intraocular lens |
US3932148A (en) * | 1975-01-21 | 1976-01-13 | Criterion Manufacturing Company, Inc. | Method and apparatus for making complex aspheric optical surfaces |
US4010496A (en) * | 1975-10-01 | 1977-03-08 | Neefe Charles W | Bifocal lens which positions within the anterior chamber |
US4014049A (en) * | 1976-04-07 | 1977-03-29 | American Optical Corporation | Artificial intraocular lens and supporting system therefor |
US4073579A (en) * | 1976-06-09 | 1978-02-14 | American Optical Corporation | Ophthalmic lens with locally variable index of refraction and method of making same |
US4074368A (en) * | 1976-09-08 | 1978-02-21 | Said Chauncey F. Levy, Jr., By Said Richard J. Pegis | Intraocular lens with high magnification |
US4195919A (en) * | 1977-10-31 | 1980-04-01 | Shelton William A | Contact lens with reduced spherical aberration for aphakic eyes |
US4315673A (en) * | 1978-04-06 | 1982-02-16 | Optische Werke G. Rodenstock | Progressive power ophthalmic lens |
US4199231A (en) * | 1978-08-21 | 1980-04-22 | Evans Carl H | Hydrogel contact lens |
US4253199A (en) * | 1978-09-25 | 1981-03-03 | Surgical Design Corporation | Surgical method and apparatus for implants for the eye |
US4244060A (en) * | 1978-12-01 | 1981-01-13 | Hoffer Kenneth J | Intraocular lens |
US4251887A (en) * | 1979-04-02 | 1981-02-24 | Anis Aziz Y | Posterior chamber capsular lens implant and method for implantation of the lens |
US4254509A (en) * | 1979-04-09 | 1981-03-10 | Tennant Jerald L | Accommodating intraocular implant |
US4244597A (en) * | 1979-05-29 | 1981-01-13 | Dandl John E | Side mounting assembly for tractor implement |
US4261065A (en) * | 1979-07-27 | 1981-04-14 | Tennant Jerald L | Artificial intraocular lens with forward-positioned optics |
US4316293A (en) * | 1979-08-27 | 1982-02-23 | Bayers Jon Herbert | Flexible intraocular lens |
US4315336A (en) * | 1980-01-21 | 1982-02-16 | Stanley Poler | Intraocular lens |
US4377329A (en) * | 1980-02-26 | 1983-03-22 | Stanley Poler | Contact lens or the like |
US4377873A (en) * | 1980-10-30 | 1983-03-29 | Reichert Jr Henry L | Intraocular lens |
US4373218A (en) * | 1980-11-17 | 1983-02-15 | Schachar Ronald A | Variable power intraocular lens and method of implanting into the posterior chamber |
US4575878A (en) * | 1981-01-30 | 1986-03-18 | Seymour Dubroff | Intraocular lenses |
US4370760A (en) * | 1981-03-25 | 1983-02-01 | Kelman Charles D | Anterior chamber intraocular lens |
US4424597A (en) * | 1981-05-13 | 1984-01-10 | Inprohold Establishment | Posterior chamber implant lens |
US4442553A (en) * | 1981-09-17 | 1984-04-17 | Hessburg Philip C | Intraocular lens |
US4504981A (en) * | 1981-09-28 | 1985-03-19 | Walman Gerald B | Intraocular lens |
US4573998A (en) * | 1982-02-05 | 1986-03-04 | Staar Surgical Co. | Methods for implantation of deformable intraocular lenses |
US4503953A (en) * | 1982-06-01 | 1985-03-12 | Rockwell International Corporation | Roller retainer for brake assembly |
US4504982A (en) * | 1982-08-05 | 1985-03-19 | Optical Radiation Corporation | Aspheric intraocular lens |
US4573775A (en) * | 1982-08-19 | 1986-03-04 | Vistakon, Inc. | Bifocal contact lens |
US4641934A (en) * | 1982-09-29 | 1987-02-10 | Pilkington P.E. Limited | Ophthalmic lens with diffractive power |
US4890913A (en) * | 1982-10-13 | 1990-01-02 | Carle John T De | Zoned multi-focal contact lens |
US4637697A (en) * | 1982-10-27 | 1987-01-20 | Pilkington P.E. Limited | Multifocal contact lenses utilizing diffraction and refraction |
US4813955A (en) * | 1983-09-07 | 1989-03-21 | Manfred Achatz | Multifocal, especially bifocal, intraocular, artificial ophthalmic lens |
US4636049A (en) * | 1983-09-20 | 1987-01-13 | University Optical Products Co. | Concentric bifocal contact lens |
US4562600A (en) * | 1983-10-18 | 1986-01-07 | Stephen P. Ginsberg | Intraocular lens |
US4636211A (en) * | 1984-03-13 | 1987-01-13 | Nielsen J Mchenry | Bifocal intra-ocular lens |
US4720286A (en) * | 1984-07-20 | 1988-01-19 | Bailey Kelvin E | Multifocus intraocular lens |
US4725278A (en) * | 1985-01-22 | 1988-02-16 | Shearing Steven P | Intraocular lens |
US4731078A (en) * | 1985-08-21 | 1988-03-15 | Kingston Technologies Limited Partnership | Intraocular lens |
US4890912A (en) * | 1986-01-24 | 1990-01-02 | Rients Visser | Trifocal eye-contact lens |
US5192318A (en) * | 1986-06-05 | 1993-03-09 | Schneider Richard T | One-piece bifocal intraocular lens construction |
US4994083A (en) * | 1986-07-22 | 1991-02-19 | Ceskoslovenska Akademie Ved | Soft intracameral lens |
US4816032A (en) * | 1987-02-11 | 1989-03-28 | Hetland Jens G | Arrangement in an intraocular anterior chamber lens |
US4898461A (en) * | 1987-06-01 | 1990-02-06 | Valdemar Portney | Multifocal ophthalmic lens |
US4906246A (en) * | 1987-08-24 | 1990-03-06 | Grendahl Dennis T | Cylindrically segmented zone of focus artificial hydrogel lens |
US4816031A (en) * | 1988-01-29 | 1989-03-28 | Pfoff David S | Intraocular lens system |
US5000559A (en) * | 1988-02-29 | 1991-03-19 | Nikon Corporation | Ophthalmic lenses having progressively variable refracting power |
US5089024A (en) * | 1988-04-19 | 1992-02-18 | Storz Instrument Company | Multi-focal intraocular lens |
US5192317A (en) * | 1988-07-26 | 1993-03-09 | Irvin Kalb | Multi focal intra-ocular lens |
US4994082A (en) * | 1988-09-09 | 1991-02-19 | Ophthalmic Ventures Limited Partnership | Accommodating intraocular lens |
US4990159A (en) * | 1988-12-02 | 1991-02-05 | Kraff Manus C | Intraocular lens apparatus with haptics of varying cross-sectional areas |
US4892543A (en) * | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
US5002382A (en) * | 1989-12-07 | 1991-03-26 | Leonard Seidner | Multifocal corneal contact lenses |
US6197059B1 (en) * | 1990-04-27 | 2001-03-06 | Medevec Licensing, B.V. | Accomodating intraocular lens |
US5496366A (en) * | 1990-04-27 | 1996-03-05 | Cumming; J. Stuart | Accommodating intraocular lens |
US5096285A (en) * | 1990-05-14 | 1992-03-17 | Iolab Corporation | Multifocal multizone diffractive ophthalmic lenses |
US5275623A (en) * | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
US20040015236A1 (en) * | 1991-11-18 | 2004-01-22 | Sarfarazi Faezeh M. | Sarfarazi elliptical accommodative intraocular lens for small incision surgery |
US5480428A (en) * | 1993-04-22 | 1996-01-02 | Mezhotraslevoi Nauchno-Tekhnichesky Komplex "Mikrokhirurgia Glaza" | Corrective intraocular lens |
US5593436A (en) * | 1993-05-12 | 1997-01-14 | Langerman; David W. | Capsular bag implants with dual 360 ring structures for inhibiting posterior capsular opacification |
US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
US6013101A (en) * | 1994-11-21 | 2000-01-11 | Acuity (Israel) Limited | Accommodating intraocular lens implant |
US5607472A (en) * | 1995-05-09 | 1997-03-04 | Emory University | Intraocular lens for restoring accommodation and allows adjustment of optical power |
US5876442A (en) * | 1998-01-15 | 1999-03-02 | Visioncare Ltd. | Intraocular lens implant with telescope support |
US6503276B2 (en) * | 1998-11-10 | 2003-01-07 | Advanced Medical Optics | Accommodating multifocal intraocular lens |
US6176878B1 (en) * | 1998-12-17 | 2001-01-23 | Allergan Sales, Inc. | Accommodating intraocular lens |
US6197058B1 (en) * | 1999-03-22 | 2001-03-06 | Valdemar Portney | Corrective intraocular lens system and intraocular lenses and lens handling device therefor |
US20100057203A1 (en) * | 1999-04-30 | 2010-03-04 | Abbott Medical Optics Inc. | Accommodating intraocular lenses |
US20030060881A1 (en) * | 1999-04-30 | 2003-03-27 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US6200342B1 (en) * | 1999-05-11 | 2001-03-13 | Marie-Jose B. Tassignon | Intraocular lens with accommodative properties |
US20030004569A1 (en) * | 2000-02-03 | 2003-01-02 | Haefliger Eduard Anton | Lens implant |
US20070050025A1 (en) * | 2001-01-25 | 2007-03-01 | Nguyen Tuan A | Hydraulic configuration for intraocular lens system |
US6858040B2 (en) * | 2001-01-25 | 2005-02-22 | Visiogen, Inc. | Hydraulic configuration for intraocular lens system |
US6846326B2 (en) * | 2001-01-25 | 2005-01-25 | Visiogen, Inc. | Connection geometry for intraocular lens system |
US6524340B2 (en) * | 2001-05-23 | 2003-02-25 | Henry M. Israel | Accommodating intraocular lens assembly |
US6855164B2 (en) * | 2001-06-11 | 2005-02-15 | Vision Solutions Technologies, Llc | Multi-focal intraocular lens, and methods for making and using same |
US20050060032A1 (en) * | 2001-06-22 | 2005-03-17 | Peter Magnante | Accommodating intraocular lens |
US20030060878A1 (en) * | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US6533813B1 (en) * | 2001-09-07 | 2003-03-18 | Chwen Yih Lin | Intraocular lens that may accommodate automatically |
US7503938B2 (en) * | 2002-03-05 | 2009-03-17 | Phillips Andrew F | Method of implanting an accommodating intraocular lens |
US7179292B2 (en) * | 2002-03-15 | 2007-02-20 | Ophtec B.V. | Intraocular lens for implantation in an eye and instrument and methods for insertion of such a lens |
US6695881B2 (en) * | 2002-04-29 | 2004-02-24 | Alcon, Inc. | Accommodative intraocular lens |
US20040039446A1 (en) * | 2002-08-26 | 2004-02-26 | Advanced Medical Optics, Inc. | Accommodating intraocular lens assembly with multi-functional capsular bag ring |
US7018409B2 (en) * | 2002-09-13 | 2006-03-28 | Advanced Medical Optics, Inc. | Accommodating intraocular lens assembly with aspheric optic design |
US7662180B2 (en) * | 2002-12-05 | 2010-02-16 | Abbott Medical Optics Inc. | Accommodating intraocular lens and method of manufacture thereof |
US20070010882A1 (en) * | 2003-02-21 | 2007-01-11 | Barrett Graham D | Intraocular lens |
US20050018504A1 (en) * | 2003-07-23 | 2005-01-27 | Filippo Marinelli | Array of non volatile split-gate memory cells for avoiding parasitic programming and programming method thereof |
US20050027354A1 (en) * | 2003-07-28 | 2005-02-03 | Advanced Medical Optics, Inc. | Primary and supplemental intraocular lens |
US7645300B2 (en) * | 2004-02-02 | 2010-01-12 | Visiogen, Inc. | Injector for intraocular lens system |
US20070021831A1 (en) * | 2005-07-19 | 2007-01-25 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
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US9814570B2 (en) | 1999-04-30 | 2017-11-14 | Abbott Medical Optics Inc. | Ophthalmic lens combinations |
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US8579970B1 (en) | 2005-06-27 | 2013-11-12 | Visiogen, Inc. | Magnifying intraocular lens |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
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US10052194B2 (en) | 2009-06-26 | 2018-08-21 | Johnson & Johnson Surgical Vision, Inc. | Accommodating intraocular lenses |
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US10772721B2 (en) | 2010-04-27 | 2020-09-15 | Lensgen, Inc. | Accommodating intraocular lens |
US8862447B2 (en) | 2010-04-30 | 2014-10-14 | Amo Groningen B.V. | Apparatus, system and method for predictive modeling to design, evaluate and optimize ophthalmic lenses |
US11506914B2 (en) | 2010-12-01 | 2022-11-22 | Amo Groningen B.V. | Multifocal lens having an optical add power progression, and a system and method of providing same |
US9931200B2 (en) | 2010-12-17 | 2018-04-03 | Amo Groningen B.V. | Ophthalmic devices, systems, and methods for optimizing peripheral vision |
US8894204B2 (en) | 2010-12-17 | 2014-11-25 | Abbott Medical Optics Inc. | Ophthalmic lens, systems and methods having at least one rotationally asymmetric diffractive structure |
JP2016203011A (en) * | 2011-02-04 | 2016-12-08 | フォーサイト・ビジョン6・インコーポレイテッドForsight Vision6, Inc. | Intraocular accommodating lens |
US11076947B2 (en) | 2011-02-04 | 2021-08-03 | Forsight Vision6, Inc. | Intraocular accommodating lens and methods of use |
US10639141B2 (en) | 2011-02-04 | 2020-05-05 | Forsight Vision6, Inc. | Intraocular accommodating lens and methods of use |
US11918458B2 (en) | 2011-02-04 | 2024-03-05 | Forsight Vision6, Inc. | Intraocular accommodating lens and methods of use |
RU2457812C1 (en) * | 2011-03-23 | 2012-08-10 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Artificial intraocular lens |
RU2457811C1 (en) * | 2011-03-23 | 2012-08-10 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Artificial intraocular lens |
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US11458011B2 (en) | 2011-10-14 | 2022-10-04 | Amo Groningen B.V. | Apparatus, system and method to account for spherical aberration at the iris plane in the design of an intraocular lens |
US9987125B2 (en) | 2012-05-02 | 2018-06-05 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
US9084674B2 (en) | 2012-05-02 | 2015-07-21 | Abbott Medical Optics Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
US8945215B2 (en) | 2012-05-10 | 2015-02-03 | Abbott Medical Optics Inc. | Accommodating intraocular lens with a compressible inner structure |
US11022815B2 (en) | 2012-08-31 | 2021-06-01 | Amo Groningen B.V. | Multi-ring lens, systems and methods for extended depth of focus |
US11389329B2 (en) | 2012-12-04 | 2022-07-19 | Amo Groningen B.V. | Lenses, systems and methods for providing binocular customized treatments to correct presbyopia |
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US10758340B2 (en) | 2013-03-11 | 2020-09-01 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens that matches an image surface to a retinal shape, and method of designing same |
US9561098B2 (en) | 2013-03-11 | 2017-02-07 | Abbott Medical Optics Inc. | Intraocular lens that matches an image surface to a retinal shape, and method of designing same |
US9861469B2 (en) | 2013-05-07 | 2018-01-09 | Akkolens International B.V. | Accommodating intraocular lens with haptics for sulcus fixation |
US11000364B2 (en) | 2013-11-01 | 2021-05-11 | Lensgen, Inc. | Two-part accommodating intraocular lens device |
US11471273B2 (en) | 2013-11-01 | 2022-10-18 | Lensgen, Inc. | Two-part accommodating intraocular lens device |
US11464624B2 (en) | 2013-11-01 | 2022-10-11 | Lensgen, Inc. | Two-part accommodating intraocular lens device |
US10842616B2 (en) | 2013-11-01 | 2020-11-24 | Lensgen, Inc. | Accommodating intraocular lens device |
US11464622B2 (en) | 2013-11-01 | 2022-10-11 | Lensgen, Inc. | Two-part accommodating intraocular lens device |
US10143548B2 (en) | 2014-03-10 | 2018-12-04 | Amo Groningen B.V. | Fresnel piggyback intraocular lens that improves overall vision where there is a local loss of retinal function |
US9636215B2 (en) | 2014-03-10 | 2017-05-02 | Amo Groningen B.V. | Enhanced toric lens that improves overall vision where there is a local loss of retinal function |
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US10016270B2 (en) | 2014-03-10 | 2018-07-10 | Amo Groningen B.V. | Dual-optic intraocular lens that improves overall vision where there is a local loss of retinal function |
US10136990B2 (en) | 2014-03-10 | 2018-11-27 | Amo Groningen B.V. | Piggyback intraocular lens that improves overall vision where there is a local loss of retinal function |
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US11331182B2 (en) | 2014-03-28 | 2022-05-17 | Forsight Vision6, Inc. | Accommodating intraocular lens |
US11660183B2 (en) | 2014-04-21 | 2023-05-30 | Amo Groningen B.V. | Ophthalmic devices, system and methods that improve peripheral vision |
US10010407B2 (en) | 2014-04-21 | 2018-07-03 | Amo Groningen B.V. | Ophthalmic devices that improve peripheral vision |
US10588739B2 (en) | 2014-04-21 | 2020-03-17 | Amo Groningen B.V. | Ophthalmic devices, system and methods that improve peripheral vision |
US11826246B2 (en) | 2014-07-31 | 2023-11-28 | Lensgen, Inc | Accommodating intraocular lens device |
US10485654B2 (en) | 2014-07-31 | 2019-11-26 | Lensgen, Inc. | Accommodating intraocular lens device |
US11464621B2 (en) | 2014-07-31 | 2022-10-11 | Lensgen, Inc. | Accommodating intraocular lens device |
US10647831B2 (en) | 2014-09-23 | 2020-05-12 | LensGens, Inc. | Polymeric material for accommodating intraocular lenses |
US20160334643A1 (en) * | 2015-05-15 | 2016-11-17 | Elwha Llc | Chromatic aberration correction lens systems and methods |
US11065107B2 (en) | 2015-12-01 | 2021-07-20 | Lensgen, Inc. | Accommodating intraocular lens device |
US11471270B2 (en) | 2015-12-01 | 2022-10-18 | Lensgen, Inc. | Accommodating intraocular lens device |
US10624735B2 (en) | 2016-02-09 | 2020-04-21 | Amo Groningen B.V. | Progressive power intraocular lens, and methods of use and manufacture |
US10709550B2 (en) | 2016-02-09 | 2020-07-14 | Amo Groningen B.V. | Progressive power intraocular lens, and methods of use and manufacture |
US11116624B2 (en) | 2016-02-09 | 2021-09-14 | Amo Groningen B.V. | Progressive power intraocular lens, and methods of use and manufacture |
US11793626B2 (en) | 2016-03-11 | 2023-10-24 | Amo Groningen B.V. | Intraocular lenses that improve peripheral vision |
US10588738B2 (en) | 2016-03-11 | 2020-03-17 | Amo Groningen B.V. | Intraocular lenses that improve peripheral vision |
US11160651B2 (en) | 2016-03-11 | 2021-11-02 | Amo Groningen B.V. | Intraocular lenses that improve peripheral vision |
US11249326B2 (en) | 2016-03-23 | 2022-02-15 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band |
US11291538B2 (en) | 2016-03-23 | 2022-04-05 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band |
US11123178B2 (en) | 2016-03-23 | 2021-09-21 | Johnson & Johnson Surgical Vision, Inc. | Power calculator for an ophthalmic apparatus with corrective meridians having extended tolerance or operation band |
US10670885B2 (en) | 2016-03-23 | 2020-06-02 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band with freeform refractive surfaces |
US10646329B2 (en) | 2016-03-23 | 2020-05-12 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band |
US10649234B2 (en) | 2016-03-23 | 2020-05-12 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band |
US11231600B2 (en) | 2016-03-23 | 2022-01-25 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band with freeform refractive surfaces |
US10712589B2 (en) | 2016-03-23 | 2020-07-14 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band by modifying refractive powers in uniform meridian distribution |
US11281025B2 (en) | 2016-03-23 | 2022-03-22 | Johnson & Johnson Surgical Vision, Inc. | Ophthalmic apparatus with corrective meridians having extended tolerance band by modifying refractive powers in uniform meridian distribution |
US11877924B2 (en) | 2016-04-19 | 2024-01-23 | Amo Groningen B.V. | Ophthalmic devices, system and methods that improve peripheral vision |
US11096778B2 (en) | 2016-04-19 | 2021-08-24 | Amo Groningen B.V. | Ophthalmic devices, system and methods that improve peripheral vision |
US10526353B2 (en) | 2016-05-27 | 2020-01-07 | Lensgen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
US11013594B2 (en) | 2016-10-25 | 2021-05-25 | Amo Groningen B.V. | Realistic eye models to design and evaluate intraocular lenses for a large field of view |
US11523898B2 (en) | 2016-10-28 | 2022-12-13 | Forsight Vision6, Inc. | Accommodating intraocular lens and methods of implantation |
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US10739227B2 (en) | 2017-03-23 | 2020-08-11 | Johnson & Johnson Surgical Vision, Inc. | Methods and systems for measuring image quality |
US11385126B2 (en) | 2017-03-23 | 2022-07-12 | Johnson & Johnson Surgical Vision, Inc. | Methods and systems for measuring image quality |
US11523897B2 (en) | 2017-06-23 | 2022-12-13 | Amo Groningen B.V. | Intraocular lenses for presbyopia treatment |
US11573433B2 (en) | 2017-06-28 | 2023-02-07 | Amo Groningen B.V. | Extended range and related intraocular lenses for presbyopia treatment |
US11914229B2 (en) | 2017-06-28 | 2024-02-27 | Amo Groningen B.V. | Diffractive lenses and related intraocular lenses for presbyopia treatment |
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US11583392B2 (en) | 2019-12-30 | 2023-02-21 | Amo Groningen B.V. | Achromatic lenses for vision treatment |
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US9814570B2 (en) | 2017-11-14 |
AU2007272697A1 (en) | 2008-01-17 |
WO2008008627A2 (en) | 2008-01-17 |
US20140135921A1 (en) | 2014-05-15 |
EP2043558A2 (en) | 2009-04-08 |
CA2661704A1 (en) | 2008-01-17 |
WO2008008627A3 (en) | 2008-12-04 |
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