US20050065609A1 - Intervertebral disc prosthesis - Google Patents
Intervertebral disc prosthesis Download PDFInfo
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- US20050065609A1 US20050065609A1 US10/496,215 US49621504A US2005065609A1 US 20050065609 A1 US20050065609 A1 US 20050065609A1 US 49621504 A US49621504 A US 49621504A US 2005065609 A1 US2005065609 A1 US 2005065609A1
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- cover
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- introducer
- flexible prosthetic
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2002/445—Intervertebral disc tissue harvest sites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
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- Cardiology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
- The present invention relates to an intervertebral disc insert for containing filling material, hydrogel or a biological replacement of a nucleus pulposis, in the form of a prosthetic jacket or cover. Such a prosthesis may be used to perform interbody fusion or to replace damaged nucleus pulposis with hydrogel or cells and matrix as a biological replacement. Such devices are useful to replace damaged disc nuclei, whether in the lumbar or other region of the spine, for example using a percutaneous fusion technique.
- The normal intervertebral disc is a highly specialized joint between the intervertebral bodies from the second cervical vertebra to the first sacral vertebra in the human body. A disc is made up of a strong outer ring called the annulus, which is strongly attached to the intervertebral bodies above and below through collagen fibers, and a central nucleus. The nucleus comprises a mesh of collagen fibers to which is attached proteoglycan molecules which are hygroscopic. It can therefore be said to consist of a central portion and an intermediate zone. The central portion comprises 90% proteoglycan and 10% collagen, and the intermediate zone rather less proteoglycan and proportionately more collagen. The annulus comprises 90% collagen with about 10% proteoglycan, which proteoglycan acts to allow a sliding motion between adjacent layers during normal daily use.
- Like all other joints in the body, intervertebral discs, particularly lumbar intervertebral discs, are subject to various types of injury, degeneration and disease. Painful disc syndromes can develop due to the destruction of the intervertebral disc structure.
- It is often the case that back pain emanating from an intervertebral disc arises from a damaged annulus because the outermost third of the annulus itself is the only part of the disc structure which is innervated. In theory then, the insertion of a prosthesis which has itself a finite structure with inherent strength but at the same time is held in position by the annulus would permit the annulus itself to heal with the commensurate relief of pain.
- Such a prosthesis has been suggested by the present applicant in WO 99/02108. This provides an intervertebral disc nucleus prosthesis generally comprising a transudative or ion transport material extended over the inner face of a prosthetic woven or porous fabric chosen for its strength and immunological neutrality. With this design, tissue can grow over and incorporate the outer fabric, while water and very low molecular weight materials can pass through the prosthetic fabric and the transudative membrane, thus eliminating, or at least substantially alleviating, any immunological problems. This allows the anchoring of the replacement nucleus pulposis within a disc space while preventing the ingrowth of bony trabeculae, thereby providing a more satisfactory long term solution.
- An alternative arrangement generally comprises a three layer cover, wherein the outer and inner layer are formed of a strong material in a sandwich construction with a middle layer of a transudative material of a small pore size. Very high pressures are present in use within the normal disc nucleus. To counteract this it is often necessary to introduce a hydrogel or other suitable substance into the cover in a liquid or powdered state. Thus, the hydrogel would have a tendency to escape through the cover were it not so constructed as to combine strength with an ability to retain the hydrogel which might otherwise leak out through the pores in the cover. This alternative jacket construction addresses this concern. Furthermore, materials have been developed which have both strength and also function as a transducive membrane, e.g. Goretex.
- Another alternative arrangement is to have a cover of a relatively impermeable material, for example polyurethane, which is both strong and bio-compatible. In such arrangements, a hydrogel and water mixture can be added in a pre-defined amount and ratio, so as to produce a consistency which substantially replicates the properties of the natural nucleus.
- The various prosthetic arrangements described above remain in position due to the snug fit within the annulus, and by virtue of the prosthesis being considerably larger than the hole in the annulus through which it was originally inserted. Also, adhesions will develop between the prosthesis and the annulus over time.
- Orientation of the prosthesis is facilitated by introducing apparatus including a tubular external valve body which may be internally screw threaded. An introducer rod is passed through the body and may have an external screw thread for engagement therewith. The rod thus serves as a stiffening device for positioning the cover in the disc cavity. Where screw threads are provided, rotation of the rod extends or retracts the distal end of the rod further to facilitate orientation of the cover. The cover preferably has a strengthened portion opposite the valve in which the distal end of the rod may be seated.
- According to the present invention, there is provided a flexible prosthetic cover shaped to form a replacement nucleus pulposis for an intervertebral disc and comprising an aperture for the introduction of filling material therein, and an elongate introducer member configured to pass into the aperture, the cover having a strengthened portion substantially opposite the aperture for engaging the distal end of the member, the strengthened portion and the said distal end being arranged to interlock so as to prevent relative rotation there between, for facilitating orientation of the cover. The aperture preferably comprises an internal valve such as a flap valve. Thus the cover may be accurately seated within the disc space without the need for an external valve body.
- In one embodiment, the distal end of the introducer member or rod may be cruciate or flat, and the strengthened portion may be a seat having a correspondingly shaped slot or cross-shaped recess for receiving it. Thus, the surgeon may extend the prosthesis into the cavity between the adjacent vertebrae, using the introducer rod as a temporary stiffening device. With the introducer rod seated in the edge portion of the prosthesis, the cover is held in the required orientation, and precise alignment may be achieved by rotating the introducer rod.
- Preferably, the strengthened portion comprises a radio-opaque marker for indicating the position or orientation of the strengthened portion, and thus of the cover.
- The introducer member may have an internal channel and an aperture at or adjacent the distal end therefore communicating with the channel for allowing the injection of filling material into the cover. Thus no further equipment will be required for injecting the filling material. Alternatively, the aperture may be arranged to accept an introducer tube shaped to pass over the introducer member and to form a channel there between for allowing the injection of filling material into the cover, after removal of the introducer member.
- The introducer member may comprise a balloon, such that when the cover is inserted into a nuclear cavity in a rolled or folded state, the balloon may be inflated to cause the cover to unfold and fill the nuclear cavity. Such an arrangement may be important where the cover is designed for a percutaneous fusion procedure, for example as outlined below.
- The cover may include a deformable porous body shaped to fit within the cover, formed for example of a very fine mesh or very loose roll or sponge of material. This may for example be made up of very fine polypropylene or other material. The body is formed in such a way that it may be inserted into the cover through the aperture either before the cover is inserted into the disc nucleus cavity, or when the cover is in place. The body may be attached to the cover. Thus, once the filling material such as hydrogel is introduced its properties may effectively be altered such that it will not flow as a liquid, but will deform in a way more similar to the natural disc nucleus.
- Where the disc nucleus has degenerated to an extent beyond that in which a prosthetic disc nucleus (as discussed above) can usefully be inserted, then an alternative is to carry out a percutaneous fusion on the affected intervertebral segment.
- According to the present invention there is also provided a prosthetic cover for an intervertebral disc comprising an edge portion comprising a resiliently deformable annular sleeve, and a pair of opposed central portions each joining an edge of the sleeve, the edge portion including an aperture for the introduction of a filling material.
- Preferably, the central portions are arranged, when the cover is filled with a filling material, to allow the filling material to pass there through.
- For example, the central portions may be formed of a weaker material than that of the edge portion, which under pressure will give to allow the filling material to burst through pores or weakened layers in it. Advantageously the material of the central portion may be made of a material which is not only weakened but will reabsorb in time allowing replacement by bone or other material so introduced. Alternatively, it may be made of an open weave or such structure as will allows the filling material to easily pass there through and come into contact with the bone of the end plates. It may allow blood vessels from the adjacent end plate bone to pass through it, and grow into the bone graft or other material placed inside the cover, to allow vascularisation of bone graft and conversion to solid bone.
- Thus, the prosthetic cover may be inserted, in the form of a substantially kidney shaped balloon, into the disc cavity following removal of the nucleus in such a way that it fits the shape of the cavity. The annular sleeve, generally in the shape of a car tyre, fits within the disc annulus, with the thin central portions adjacent the end plates of the superior and inferior vertebral bodies. When a filling material is injected into the cover under pressure, the material breaks the weakened central portions, or bursts through the open weave, and pressurizes the annular sleeve against the annulus, thereby preventing its escape through any weaknesses or tears in the disc annulus that may be present.
- The end plates of the vertebral bodies are preferably prepared by creating holes in them. When the filling material, which may be cement or bone substitute material, bursts through the central portions, it may communicate directly with the prepared end plates of the vertebral bodies, and “key” into holes created in them.
- Seating of the cover may alternatively be achieved by insertion of a balloon catheter into the cover, which is inflated to fill the inside thereof. After ensuring correct seating, the balloon is deflated and an outer filling tube is passed over it into the cover. The balloon may then be removed and the material injected.
- The aperture may be provided as part of a valve structure, which is preferably formed of an imaging transparent material, for example titanium, carbon fibre or a durable biocompatible plastics material such as polypropylene. In one preferred embodiment, the valve structure includes a one way valve arrangement which may be a flap valve partially attached to an inside of the cover, such that the valve structure will be in a closed state when an internal pressure of the cover exceeds an exterior or injection pressure of the hydrogel material. Alternatively, the one way valve arrangement may be a conical nose with a narrower internal opening, again directing the valve structure to a closed state under similar circumstances. The conical configuration facilities insertion of the introducer rod.
- The valve structure may comprise a valve body with a longitudinal bore therein, and obturating means associated with the bore. The valve body is configured to be fluidly secured to the edge portion of the prosthetic device. For example, an exterior portion of the valve body may be attached to the edge portion of the cover such that the longitudinal bore is in fluid communication with an interior of the cover. The obturating means is configured to selectively allow passage of filling material, such as hydrogel through the longitudinal bore. The valve body may be generally symmetrical and the longitudinal bore may extend axially within the valve body.
- Any suitable filling material may be used, for example polyvinyl alcohol. The filling material may be hydrogel, for example a polyvinyl alcohol material, such as HYPAN®, developed into a fluid or liquid form which will easily pass through the valve structure and subsequently harden. Ideally, the swelling pressure of the resultant hydrogel is in a range similar to, or as close as possible to, a normal lumbar intervertebral disc. Ideally, a hydrogel is used which has similar Theological properties to the normal nucleus.
- The prosthesis of the present invention is preferably sized such that an internal surface area of a nuclear cavity is virtually the same as the prosthesis. This will ensure that load distribution within the resulting prosthesis is similar to that of a normal intervertebral disc. The technology of hydrogels at the present time means that the swelling pressure of hydrogel can only approximate to one quarter or one third of a normal disc. So to retain their ability to maintain disc height, it is preferable to form the hydrogel as a solid or semi-solid material, or that the hydrogel harden or cure following injection into the cover.
- Alternatively, introduction of a mesh or loose coil or sponge of a fine deformable material into the cover prior to injection of the hydrogel may be carried out. This will have the effect that when the hydrogel sets, the gel, mesh and cover will form an integral structure with similar Theological properties to the normal nucleus. In one alternative embodiment, a fine wire of a radiolucent material is incorporated within the prosthesis to demonstrate the position of a prosthesis in vivo.
- In use, one preferred method of insertion of a prosthesis in accordance with the present invention is as follows:—
- A small skin incision is made with the point of a knife adjacent a damaged intervertebral disc, including an annulus and a nucleus, which has previously been extensively imaged by a Computer Tomography or Magnetic Resonance Imaging. If necessary, confirmation that it is the disc which is painful may be reached by effecting provocative stress discography. This allows percutaneous disc surgery to be carried out by a lateral approach whereby an operating port and trochar is used to insert instruments laterally between adjacent vertebrae in the spine through the paraspinal musculature so entering the disc at the postlateral corner in the safe triangle, inferior to the exiting nerve root. The trochar creates a hole by spreading the fibres of the annulus and provides for access to the nucleus portion of the intervertebral disc.
- Chymopapain may be injected into the nucleus to digest the proteoglycan structure thereof. Mechanical action as by a brush with polypropylene bristles may be used to aid the breakdown of any remaining collagen structure to enhance the effect of chymopapain which may then be removed by suction. Subsequently an intervertebral disc nucleus prosthesis in accordance with the present invention is introduced through the disc annulus. The disc annulus comprises an outer ring of strong collagenous fibrous tissue. As previously described, the prosthesis preferably includes a cover having an edge portion shaped to fit within the annulus, and a valve structure. The valve structure, in one preferred embodiment, includes the one-way valve arrangement (or conical nose) and a body that may be knurled or fluted as appropriate. A strengthening portion may be incorporated into the edge portion immediately opposite the valve structure for receiving a distal end of an introducer rod. This allows the relatively atraumatic insertion of the prosthesis cover through the annulus into the space created by the removed nucleus.
- Prior to insertion, the external valve structure of the prosthesis is preferably attached to an external introducer tube, and the introducer rod is coaxially positioned within the external introducer tube, and passes through the external valve structure. The introducer rod serves as a temporary stiffening device, allowing a surgeon to apply a pushing force on the cover. Thus, with proper positioning of the introducer rod, engaged with the strengthened portion in the edge portion of the cover, the surgeon can extend the prosthesis cover into the cavity between adjacent vertebrae. The function of the strengthened portion is to protect the cover from damage by introducing the introducer rod. The external introducer may then be rotated to precisely align the strengthened portion of the cover within the annulus. The introducer rod may be movable along its longitudinal axis, or may be releasably attachable to the valve structure by a screw thread. In one preferred embodiment, both the internal and external introducers are attached to a prosthesis prior to insertion, and the prosthesis is folded in such a way as to ensure its ease of passage through the annulus into the nucleus. Such an arrangement may be formed and inserted inside a delivery tube, which would in turn be passed through the operating port to engage the hole in the annulus, and ease passage of the cover into the nuclear cavity.
- In a preferred embodiment, the cover preferably contains a collapsible sponge, a mesh, or a fine coil which fills the cover, and has a memory such that after insertion through the annulus into the disc space, the sponge, mesh or coil will return to its previous shape, i.e. the shape of the nucleus, and will expand within the cover to fill the disc space. Once the prosthesis is positioned within the disc space, the introducer rod is withdrawn. Hydrogel material is then introduced into the prosthesis cover via a syringe connected to the external introducer tube. In one preferred embodiment, a distal end of the syringe is directed through the external introducer tube and secured to the valve structure. With this approach, the syringe has an internal seal, to ensure that the hydrogel material passes through the valve structure into the cover, and a locking mechanism to ensure a tight seal with the valve structure. This may be achieved by an arrangement, similar to the tubular spanner, in which the external introducer tube is arranged to receive the syringe, and has grooves to form a bayonet type fitting with pins provided on the syringe.
- The syringe of this embodiment further includes a tubular piston rod and a piston that is selectively secured to a screw configured to immediately close the valve structure after injection of the hydrogel. In one embodiment, once a desired volume of hydrogel has been injected into the cover of the prosthesis, and the piston is at the bottom of the syringe, a screw driver may be passed down a center of the piston to insert and tighten the screw to the valve structure.
- Alternatively, the screw and the screw driver may be incorporated together into the piston, and the piston rod simply turned to secure the screw to the valve structure. Alternatively, the external introducer tube may be a cannula including two proximal ports to facilitate injection of the hydrogel material. With this configuration, a syringe is secured to one of the two proximal ports. Hydrogel material is forced from the syringe into the external introducer tube. The external introducer tube, in turn, directs the hydrogel material to the valve structure and then into the prosthetic cover. With the prosthesis filled adequately with hydrogel material to a desired internal pressure, a screw is then passed through the external introducer tube and secured to the valve structure so as to retain the contents of the prosthesis. In the event that the volume of hydrogel material needs to be subsequently altered, this can be performed in a substantially non-traumatic way by merely removing the screw and replacing the contents of the prosthesic cover as necessary.
- In an alternative embodiment, where an external valve structure is not used, the introducer rod passes through a conical valve and engages with the strengthened portion of the cover. In this embodiment, the cover can lock with the introducer rod by way of a cruciate flattened section at the distal end of the introducer rod. Once the prosthesis is in position, a cannula is passed over the introducer rod, which is then removed, leaving the cannula in position within the cover. As mentioned hereinbefore, a sponge, mesh or fine wire fill the cover, and may already be present within the cover, or may be inserted through the introducer tube into the cover. Once the cover is expanded in position, hydrogel is injected to fill the cover, encompassing the sponge, or mesh, or coil, before setting within the cover.
- One aspect of the present invention will now be described in detail by way of illustration only with reference to the accompanying drawings.
-
FIG. 1A is a side sectional view of an intervertebral disc nucleus prosthesis in accordance with the present invention; -
FIG. 1B is a top sectional view of the prosthesis ofFIG. 1A ; -
FIGS. 1C and 1D each show a side sectional view of the prosthesis ofFIG. 1B taken along the lines I-I, and a perspective view of the distal end of the corresponding introducer rod, used with the external valve structure is not used; -
FIG. 2A is an enlarged side sectional view of the prosthesis ofFIG. 1A , including an introducer rod and external introducer tube; -
FIG. 2B is an enlarged, top sectional view of the arrangement ofFIG. 2A ; -
FIG. 3 shows inFIG. 3A a vertical section through an intervertebral disc in the process of removal of a damaged nucleus pulposis; -
FIG. 3B shows the same view in transverse cross-section; -
FIG. 4 , shows inFIG. 4A a cross-section a prosthetic cover in accordance with the present invention being introduced between adjacent vertebrae, whereasFIG. 4B shows the same view of the cover in accordance with the present invention being introduced in transverse cross-section; -
FIG. 5 shows inFIG. 5A the insertion of a hydrogel into the prosthesis in accordance with the present invention in vertical cross-section, whereasFIG. 5B shows the same view in transverse section, andFIGS. 5C and 5D show cross-sectional views of a syringe for use with the prosthesis; -
FIG. 6 shows inFIG. 6A a vertical cross-section of the completed prosthesis, whileFIG. 6B shows the same view asFIG. 6A in transverse cross-section; and -
FIG. 7 shows inFIGS. 7A and 7B alternative embodiments of a further prosthesis and introducer rod according to the invention. - One embodiment of an intervertebral
disc nucleus prosthesis 10 is shown inFIGS. 1A and 1B . Theprosthesis 10 includes acover 12, afiller material 14 and an aperture in the cover comprising avalve structure 16. Thecover 12 encompasses thefiller material 14 and is sealed to a portion of thevalve structure 16. In this regard, thevalve structure 16 is fluidly connected to an interior of thecover 12. Notably, theprosthesis 10 is shownFIGS. 1A and 1B in an inflated state. - The
cover 12 is generally in the form of a kidney shaped balloon comprising an edge portion in the shape of anannular sleeve 13, having a shape generally similar to that of a car tyre, and two opposedcentral portions 15 joining each edge of thesleeve 13 to close thecover 12. Thesleeve 13 is formed of a resilient deformable material and is shaped to fit within the annulus of an intervertebral disc following removal of the disc nucleus, as described below. Thecentral portions 15 are formed of a flexible thin or weakened material, which allows the passage of thefiller material 14 there through under pressure. For example, the flexible material may break or allow thefiller material 14 to burst through pores or weakened layers in it under filling pressure. For example, the filler material may be a composite hydroxy apatite paste, configured to harden within thecover 12 between vertebral bodies. When injected under pressure, the filler material will key into holes in the vertebral bodies. The composite hydroxy apatite paste hardens to a cement composition which provides support for the spine, and ingrowth of blood vessels from the vertebral end plates. Eventually the structure will remodel into bone. The cover may alternatively be filled by packing small fragments of a porous hydroxyapetite, such as Apapore, into the cavity, which will absorb blood and bone marrow from the vertebral end plates into its pores. It thus forms a gelatinous semi-solid structure when the blood and bone marrow clots, which will vascularise as previously described and form into bone. - Alternatively, as described in WO 99/02108, the
filler material 14 may be a hydrogel material, which is flowable in a first state and relatively rigid in a second state. In one preferred embodiment, the hydrogel material is polyvinyl alcohol based configured to transition from a liquid form in a first state to a hardened or cured form in a second state. For example, thehydrogel material 14 may be HYPAN®, available from Hymedix International, Inc. Preferably, thehydrogel material 14 has a consistency and swelling pressure of a normal disc nucleus. Additionally, as referred to hereinabove, thehydrogel material 14, in an alternative embodiment, may be reinforced by introducing a sponge, mesh or fine wire inside thecover 12, either before introduction of thecover 12 into a disc space, or after via the introducer tube, and injecting thehydrogel material 14 in a liquid state into thecover 12 such that thehydrogel material 14 cures around the mesh. The resulting structure would be more able to resist stresses in a way similar to the normal disc nucleus. The mesh would be introduced into thecover 12 prior to implant, and may be a fine polypropylene thread. With this configuration, the mesh would easily deform to facilitate insertion of thecover 12 into the nucleus, after which the mesh would spring out once again to fill thecover 12. - The
valve structure 16 preferably includes a one-way valve 18, and anextension body 20. The one-way valve 18 is integrally formed with theextension body 20, the combination of which forms alongitudinal bore 24 through thevalve structure 16. The one-way valve 18 is shown inFIGS. 1A and 1B as being a conical nose. With this configuration, the conical nose restricts flow of thefiller material 14 from thecover 12 through thevalve structure 16. Alternatively, the one-way valve 18 may be a flap valve (described in greater detail below) to further inhibit back flow of thehydrogel material 14 out from thecover 12. - The
filler material 14 may be a soup or growth medium containing nuclear cells or cartilage cells which have been previously removed from the patient, and grown in an artificial medium until enough cells are present to fill the nuclear cavity, These cells may then be injected into the nuclear cavity space so as to substantially fill the cavity with this material, which will allow the body to replicate and rebuild a nuclear structure. In such embodiments, the cover may be made of a degradable plastics material, which, when degraded, will be replaced by a collagen structure which replicates the normal nucleus. - As shown in
FIGS. 1A and 1B , thesleeve 13 is secured about the one-way valve 18 portion of thevalve structure 16, and theextension body 20 extends from thesleeve 13. The cover includes a shaped strengthenedportion 26 positioned opposite thevalve structure 16 for providing a seat for the introducer rod. The shapedportion 26 is formed at an interior of thesleeve 13, and may assume a circular form, having a shape such as a slot to engage with a distal end of an introducer rod, as described below. Alternatively, the shapedportion 26 may have a cylindrical recess, into which the distal end of the introducer rod may be rotatably inserted. - The intervertebral
disc nucleus prosthesis 10 is shown in greater detail inFIGS. 2A and 2B . Notably, theprosthesis 10 is shown in a deflated state, with the filler material 14 (FIGS. 1A and 1B ) removed from thecover 12. Additionally, theprosthesis 10 is shown inFIGS. 2A and 28 as being attached to anintroducer rod 28 and anexternal introducer tube 40. Theextension body 20 of thevalve structure 16 includes aproximal portion 32 and adistal portion 34. In this regard, theproximal portion 32 is connected to the one-way valve 18. - Use of the
introducer rod 28 and theexternal introducer tube 40 is described in greater detail below. Generally speaking theexternal introducer tube 40 is an elongate tube having an internal passage. The internal passage of theexternal introducer tube 40 has a diameter approximating to an outer diameter of theextension body 20. Theintroducer rod 28 is a relatively stiff member having a diameter less than that of the internal passage of theexternal introducer tube 40. Thus, theintroducer rod 28 is coaxially received in theexternal introducer tube 40. Further, theintroducer rod 28 includes adistal end 42 which is shaped, for example cruciate, slotted, or cylindrical as required, to engage with the shapedportion 26 of the cover. Theintroducer rod 28 has a diameter approximating to that of thelongitudinal bore 24 of thevalve structure 16 but has a diameter slightly less than the longitudinal bore so as to be able to freely rotate therein. Alternatively, theintroducer rod 28 may be partially screw threaded to engage the inside of the valve structure. - The
distal end 42 of theintroducer rod 28 may, for example, be flattened and the shapedportion 26 of thecover 12 may have a corresponding elongate slot or groove 27 as shown inFIG. 1C . Alternatively, thedistal end 42 may have another shape such as a cruciate form, and the shapedportion 26 may have a corresponding recess or groove 29 as shown inFIG. 1D . - A preferred method of implanting the intervertebral
disc nucleus prosthesis 10 is substantially as follows. A patient is first extensively imaged by traditional means to obtain the level and condition of a damageddisc 50, in the present case a damaged lumbar disc, as shown inFIGS. 3A and 3B . Thedisc 50 is basically comprised of anannulus 52 and opposingend plates 54 surrounding anucleus 56. - Following imaging, the
nucleus 56 may be removed as is shown inFIGS. 3A ands 3B. A preferred lateral percutaneous approach to thedisc 50 is used. An incision is made in the skin at the appropriate point, and under imaging control a needle is passed to the posterolateral point of the annulus. The tissues are then dilated by a series of dilating tubes, and finally an operatingport 30 is passed down to the level of the annulus. The dilators are then removed, leaving an operating channel. Ahole 58 is imparted to access thenucleus 56, and a needle (not shown) of appropriate bore is used to enter thenucleus 56 via thehole 58 and chymopapain is injected to digest the proteoglycan of thenucleus 56. This may be done either prior to the creation of thehole 58 or through it. A polypropylene bristle brush (not shown) may then be inserted to help break down any remaining structure of thenucleus 56 and to aid the digestion of thenucleus 56, which may be removed by suction. Additionally or alternatively, the nucleus may be removed piecemeal by rongeurs. - Subsequently, the
external introducer tube 40, otherwise attached to theprosthesis 10 as previously described, is utilized. It should be recalled that at this stage, thecover 12 is deflated or empty. In this position, thelongitudinal bore 24 of thevalve structure 16 is aligned with the internal passage of theexternal introducer tube 40. Theintroducer rod 28 is then coaxially placed through the internal passage and thelongitudinal bore 24. Thedistal end 42 engages the shapedportion 26 of thecover 12, such that the flattened portion fits into thegroove 27. Thus, theintroducer rod 28 can be extended within thecover 12 to define a preferred diameter of the cover, approximately that of the disc 50 (FIG. 3A ), and to hold thecover 12 in the correct orientation. - The surgeon then directs the
external introducer tube 40 to insert thecover 12 within thedisc 50 as shown inFIGS. 4A and 4B . More particularly, thecover 12 is directed through thehole 58 in theannulus 52 to the area once occupied by thenucleus 56. Theintroducer rod 28 acts as a stiffener, allowing the surgeon to push or force thecover 12 through theannulus 52 and into the area occupied by thenucleus 56. Rotation of theintroducer rod 28 causes thesleeve 13 to rotate therewith. Thus the surgeon may control the orientation of the cover to align thesleeve 13 precisely within thedisc annulus 52. - Notably, the operating
port 30 is shown inFIGS. 4A and 4B as a cannula having twoproximal ports introducer rod 28 and theexternal introducer tube 40 are positioned to extend outwardly from the firstproximal port 74. - Once the
cover 12 has been properly positioned within the space previously occupied by thenucleus 56, theintroducer rod 28 is retracted from theexternal introducer tube 40. More particularly, theintroducer rod 28 is withdrawn both from thelongitudinal bore 24 of thevalve structure 16 and towards the firstproximal port 74. Theintroducer rod 28 may be fully withdrawn from the firstproximal port 74 so long as a cap (not shown) is used to prevent any back flow of thehydrogel material 14. - The filler material, which may be a composite ceramic paste, or
hydrogel material 14, is then injected into thecover 12, as shown inFIGS. 5A and 5B which depict theprosthetic cover 12 in a fully inflated state. This is achieved in two possible ways. Firstly, a measured amount of thefiller material 14 is introduced into a specially designed syringe as shown inFIGS. 5C and 5D . Thesyringe 80 is long and slender, having aseal 81 at the distal end thereof, and is introduced into theexternal introducer tube 40 and locks into it in such a way that it forms a seal with thevalve structure 16. This may be achieved by a locking mechanism, similar to the tubular spanner arrangement as described previously, wherein thesyringe 82 inserted into the introducer tube has two opposed lockinggrooves 84 for engagingopposed pins 86 provided on the outside of thesyringe 80, at the proximal end thereof, in the manner of a bayonet fitting. - The
filler material 14 is injected into theprosthesis cover 12 until apiston 88 of the syringe is adjacent thevalve structure 16. In a preferred embodiment, the piston of the syringe includes a lockingscrew 22 embedded in it which can be secured to theproximal portion 32 of the external valve structure. Thus the piston acts as a screw-driver such that after the hydrogel has been injected, the screw engages the hole in the external valve and the screw driver is turned to tighten it. The syringe may then be withdrawn by releasing thepins 86 from thegrooves 84. - The
filler material 14 may be introduced via the secondproximal port 76 and flows down theinternal passage 40 of theexternal introducer tube 40 through thebore 24 in thevalve structure 16 and into the deflatedprosthetic cover 12 so as to inflate the same to the position shown inFIG. 5A . The introduction of thefiller material 14 is continued until theprosthetic cover 12 is adequately filled with thehydrogel material 14. - With reference now to
FIG. 6 ,FIGS. 6A and 6B show sealing of thevalve structure 16. A screwdriver (not shown) having aset screw 22 is introduced through theexternal introducer tube 40 and pressed through any remaining thefiller material 14 until the screw thread on the sealing setscrew 22 comes into contact with the internal thread 38 in theextension body 20 of thevalve structure 16. Thescrew 22 is then rotated to close thebore 24. With thescrew 22 secured to thevalve structure 16, theeternal introducer tube 40 is disengaged from theprosthesis valve structure 16. - The screw driver can freely rotate with the tubular introducer, and engages with grooves in the valve so preventing rotation of the valve by retaining the tubular screw driver against rotation. The tubular introducer is then disengaged from the valve structure whereupon the screw driver is removed.
- In an alternative method of seating the cover, a balloon catheter (not shown) is provided. This is inserted into the cover and inflated to fill the inside and ensure correct positioning. The balloon may then be deflated and an outer filling tube passed over it into the cover. The balloon is then removed and the material injected into the cover. In this case, the external valve structure and introducer rod may not be required, and a simple flap may be provided over the aperture to act as a one-way valve.
- By means of the foregoing process, a replacement nucleus pulposis can be inserted between adjacent vertebrae successfully with the removal of pain and incapacity, and prevention of the development of secondary degenerative changes in the disc due to the replacement of damaged or degenerated intervertebral disc. Where the disc has degenerated beyond repair, a percutaneous fusion may be performed by injecting a hydroxy apatite cement into a cover with a strengthened annular sleeve and weakened central portions each joining an edge of the sleeve.
- The invention relates therefore to the improved prosthetic device, and to a method for its insertion.
- In an alternative form of the
prosthesis 10, thevalve structure 16 may allow passage of theintroducer rod 28 through theflap valve 18 to engage the strengthenedportion 26. In this latter case, theintroducer rod 28 consists of a cannula with an internal trochar having a shaped internal end which engages the strengthenedportion 26. Theprosthesis 10 is inserted by pushing it into the nuclear cavity whereupon the trochar is removed. A syringe, containing the hydrogel material or ahydroxy apatite paste 14 is then attached to the external end of the cannula and the hydrogel material orhydroxy apatite paste 14 injected. Since the internal pressure is greater than the injection pressure, theflap valve 18 will close on removal of the cannula. The hole (or operating port) 58 in theannulus 52 will tend to close as the fibres are stretched, so that theprosthesis 10 which by this time is far greater in size than the operatingport 58 is easily retained in position. - In another embodiment, as shown in
FIGS. 7A and 7B , the cover may be a simpleflexible jacket 60 having aflap valve 62 as previously described. In this case a radio-opaque marker is provided in the strengthenedportion 64 such that its position and orientation may be visualized radiologically. Where no external valve body is provided as in this example, the introducer rod not only introduces the cover into the center of the disc, but also acts as a means by which the filler material is injected into the cover. Therefore, referring toFIG. 7A up to the point where it is shaped at the distal end to engage the strengthened portion, theintroducer rod 66 is tubular. Filling material can be injected through the tube into the cover throughside openings 68 therein. - Alternatively, referring to
FIG. 7B , anouter tube 70 may be inserted over therod 72 into the aperture of thecover 60. Theintroducer rod 72 may or may not be removed, and the filling material can be injected through theouter tube 70. - Such a flexible cover preferably includes the mesh structure previously described.
Claims (17)
Priority Applications (2)
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US12/721,095 US8506630B2 (en) | 2001-11-19 | 2010-03-10 | Intervertebral disc prosthesis |
US13/939,672 US20130297025A1 (en) | 2001-11-19 | 2013-07-11 | Intervertebral disc prosthesis |
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GB0127697A GB2382028B (en) | 2001-11-19 | 2001-11-19 | Intervertebral disc prosthesis |
GB0127697.1 | 2001-11-19 | ||
PCT/GB2002/005210 WO2003043535A2 (en) | 2001-11-19 | 2002-11-19 | Intervertebral disc prosthesis |
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US12/721,095 Continuation US8506630B2 (en) | 2001-11-19 | 2010-03-10 | Intervertebral disc prosthesis |
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US12/721,095 Expired - Fee Related US8506630B2 (en) | 2001-11-19 | 2010-03-10 | Intervertebral disc prosthesis |
US13/939,672 Abandoned US20130297025A1 (en) | 2001-11-19 | 2013-07-11 | Intervertebral disc prosthesis |
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US13/939,672 Abandoned US20130297025A1 (en) | 2001-11-19 | 2013-07-11 | Intervertebral disc prosthesis |
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EP (2) | EP1448115B1 (en) |
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JP2005509487A (en) | 2005-04-14 |
AU2002366001A1 (en) | 2003-06-10 |
DE60229159D1 (en) | 2008-11-13 |
CA2466674C (en) | 2010-12-21 |
US20100168859A1 (en) | 2010-07-01 |
EP1985260B1 (en) | 2010-07-14 |
GB0127697D0 (en) | 2002-01-09 |
CA2466674A1 (en) | 2003-05-30 |
ATE473709T1 (en) | 2010-07-15 |
WO2003043535A3 (en) | 2003-08-21 |
US8506630B2 (en) | 2013-08-13 |
US20130297025A1 (en) | 2013-11-07 |
GB2382028A (en) | 2003-05-21 |
DE60237052D1 (en) | 2010-08-26 |
ES2312664T3 (en) | 2009-03-01 |
EP1985260A1 (en) | 2008-10-29 |
GB2382028B (en) | 2006-11-01 |
WO2003043535A2 (en) | 2003-05-30 |
EP1448115B1 (en) | 2008-10-01 |
EP1448115A2 (en) | 2004-08-25 |
ATE409443T1 (en) | 2008-10-15 |
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