US20040127401A1 - CA125 gene and its use for diagnostic and therapeutic interventions - Google Patents

CA125 gene and its use for diagnostic and therapeutic interventions Download PDF

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US20040127401A1
US20040127401A1 US10/715,066 US71506603A US2004127401A1 US 20040127401 A1 US20040127401 A1 US 20040127401A1 US 71506603 A US71506603 A US 71506603A US 2004127401 A1 US2004127401 A1 US 2004127401A1
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Timothy O'Brien
John Beard
Lowell Underwood
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University of Arkansas
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Publication of US20040127401A1 publication Critical patent/US20040127401A1/en
Assigned to BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE reassignment BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEARD, JOHN B., O'BRIEN, TIMOTHY J., UNDERWOOD, LOWELL J.
Priority to US12/455,366 priority patent/US9556245B2/en
Priority to US15/420,068 priority patent/US20170305980A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Definitions

  • the present invention relates generally to the cloning, identification, and expression of the CA125 gene's glycosylated amino terminal domain, the multiple repeat domain, and the carboxy terminal domain in vitro and, more specifically, to the use of recombinant CA125 with epitope binding sites for diagnostic and therapeutic purposes. Additionally, the genomic DNA, a molecule encoding a 5′ upstream region of CA125 and a genomic DNA sequence for the amino terminal, extra cellular repeats and carboxy terminal of CA125 has been determined.
  • CA125 is an antigenic determinant located on the surface of ovarian carcinoma cells with essentially no expression in normal adult ovarian tissue. Elevated in the sera of patients with ovarian adenocarcinoma, CA125 has played a critical role for more than 15 years in the management of these patients relative to their response to therapy and also as an indicator of recurrent disease.
  • CA125 is not uniquely expressed in ovarian carcinoma, but is also found in both normal secretory tissues and other carcinomas (i.e., pancreas, liver, colon) [Hardardottir H et al., Distribution of CA125 in embryonic tissue and adult derivatives of the fetal periderm, Am J Obstet. Gynecol. 163;6(1):1925-1931 (1990); Zurawski V R et al., Tissue distribution and characteristics of the CA125 antigen, Cancer Rev. 11-12:102-108 (1988); and O'Brien T J et al., CA125 antigen in human amniotic fluid and fetal membranes, Am J Obstet Gynecol.
  • CA125 correlates directly with the disease status of affected patients (i.e., progression, regression, and no change), and has become the “gold standard” for monitoring patients with ovarian carcinoma [Bast R C et al., A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer, N Engl J Med.
  • CA125 is especially useful in post-menopausal patients where endometrial tissue has become atrophic and, as a result, is not a major source of normal circulating CA125.
  • M11 a monoclonal antibody to CA125.
  • M11 binds to a dominant epitope on the repeat structure of the CA125 molecule [O'Brien T J et al., New monoclonal antibodies identify the glycoprotein carrying the CA125 epitope, Am J Obstet Gynecol 165:1857-64 (1991)].
  • CA125 molecule is a high molecular weight glycoprotein with a predominance of O-linked sugar side chains.
  • the native molecule exists as a very large complex ( ⁇ 2-5 million daltons).
  • the complex appears to be composed of an epitope containing CA125 molecule and binding proteins which carry no CA125 epitopes.
  • the CA125 molecule is heterogenous in both size and charge, most likely due to continuous deglycosylation of the side chains during its life-span in bodily fluids.
  • the core CA125 subunit is in excess of 200,000 daltons, and retains the capacity to bind both OC125 and M11 class antibodies.
  • a recombinant CA125 cDNA molecule which can be introduced into animals or human cells to achieve transcription or expression of the cDNA.
  • the utility of knowing the DNA sequence of a specific gene is that a recombinant protein can be produced which can be used as an easily renewable source of that gene or a portion of the gene. Producing and purifying recombinant protein is easier and can produce greater quantities of protein than purifying native protein from patients.
  • the recombinant protein can then be used to produce antibodies to the gene, both polyclonal and monoclonal.
  • the recombinant protein can also be used as a positive control in test kits and experiments.
  • the genomic sequence for CA125 and a 5′ upstream region has been determined.
  • a DNA sequence showing the 5′ upstream region and the amino terminal portion of the CA125 molecule is set out in Table 1 and SEQ ID NO: 1.
  • the extracellular amino terminal domain is made of exons: Exon 1 from 2205-11679; Exon 2 from 13464-13570; Exon 3 from 16177-34419; Exon 4 from 34575-38024; Exon 5 from 38689-38800; Exon 6 from 40578-45257; Exon 7 from 47360-47395; Exon 8 from 52407-52442; Exon 9 from 52686-52744 as set out in SEQ ID NO: 1.
  • a DNA sequence showing the extracellular repeat portion of the CA125 molecule is set out in Table 2 and SEQ ID NO: 2.
  • the genomic repeats are made of exons: Exon R1 from 1-130; Exon R2 from 442-510; Exon R3 from 5479-5652; Exon R4 from 6301-6334; Exon R5 from 6593-6657; Exon R1 from 7558-7683; Exon R from 8216-8284; Exon R3 from 8877-9050; Exon R4 from 9380-9413; Exon R5 from 9675-9739; Exon R1 from 10201-10291; Exon R2 from 10524-10592; Exon R3 from 11200-11373; Exon R4 from 11722-11755; Exon R5 from 12016-12036; Exon R1 from 12169-12295; Exon R2 from 12532-12600; Exon R3 from 13219-13392; Exon R4 from 13723-13756; Exon R5 from
  • a DNA sequence showing the carboxy terminal domain of the CA125 molecule is set out in Table 3 and SEQ ID NO: 3.
  • the carboxy terminal portion is made of exons: Exon Cl from 1-66; Exon C2 from 1802-1947; Exon C3 from 4198-4350; Exon C4 from 4679-4747; Exon C5 from 6811-6978; Exon C6 from 11232-11270; Exon C7 from 11594-11677; Exon C8 from 14095-14187 as set out in SEQ ID NO: 3.
  • a full length cDNA molecule for CA125 is set out in Table 4 and SEQ ID NO: 4.
  • a CA125 protein is set out in Table 5 and SEQ ID NO: 5.
  • DNA sequence which encodes CA125 has been discovered known synthetic methods can be employed to prepare DNA molecules containing portions of the sequence.
  • Conventional cloning vehicles such as plasmids, viruses, or bacteria phages can be modified using known methods so as to produce novel cloning vehicles which contain cDNA encoding, CA125, analogs or mutants thereof.
  • such cloning vehicles can be modified or engineered so that they contain DNA molecules from Table 4 and SEQ ID NO: 4 or segments substantially similar thereto.
  • the DNA molecule inserted may be made by various methods including enzymatic or chemical synthesis.
  • CA125 The CA125 gene has been cloned and multiple repeat sequences as well as the glycosylated amino terminal and the carboxy terminus have been identified.
  • CA125 requires a transcript of more than 35,000 bases and occupies approximately 150,000 bp on chromosome 19p 13.2.
  • the CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain.
  • the amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon.
  • This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. Analysis of the amino terminal extension revealed that its amino acid composition is consistent with the amino acid composition of the amino terminal domain.
  • the multiple repeat domains of CA125 or other domains could also be used for the development of a potential vaccine for patients with ovarian cancer.
  • murine antibodies specific for CA125 were utilized in anticipation of patient production of anti-ideotypic antibodies, thus indirectly allowing the induction of an immune response to the CA125 molecule.
  • the recombinant CA125 of the present invention may also be used to develop therapeutic targets.
  • Molecules like CA125 which are expressed on the surface of tumor cells, provide potential targets for immune stimulation, drug delivery, biological modifier delivery or any agent which can be specifically delivered to ultimately kill the tumor cells.
  • Humanized or human antibodies to CA125 epitopes could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells.
  • Natural ligands having a natural binding affinity for domains on the CA125 molecule could also be utilized to deliver therapeutic agents to tumor cells.
  • CA125 expression may further provide a survival or metastatic advantage to ovarian tumor cells.
  • Antisense oligonucleotides derived from the CA125 repeat sequences could be used to down-regulate the expression of CA125. Further, antisense therapy could be used in association with a tumor cell delivery system of the type described above.
  • Recombinant domains of the CA125 molecule also have the potential to identify small molecules, which bind to individual domains of the CA125 molecule. These small molecules could also be used as delivery agents or as biological modifiers.
  • an isolated nucleic acid of the CA125 gene which comprises a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequences set forth in SEQ ID NOS: 1, 2, 3 and 4; (b) a nucleotide sequence having at least 70% sequence identity to any one of the sequences in (a); (c) a degenerate variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c).
  • an isolated nucleic acid of the CA125 gene comprising a sequence that encodes a polypeptide with the amino acid sequence selected from the group consisting of: (a) the amino acid sequences set forth in SEQ ID NO: 5; (b) an amino acid sequence having at least 50% sequence identity to any one of the sequences in (a); (c) a conservative variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c).
  • the vector may be a cloning vector, a shuttle vector, or an expression vector.
  • a cultured cell comprising the vector is also contemplated.
  • this invention relates to a purified antibody that selectively binds to an epitope in the CA125 protein of SEQ ID NO: 5.
  • the purified antibody selectively binds to an amino acid sequence having at least 50% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 60% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 70% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 80% sequence identity to said sequence; and the purified antibody selectively binds to an amino acid sequence having at least 90% sequence identity to said sequence.
  • purified antibody can be a conservative variant of the amino acid sequence set forth in SEQ ID NO: 5 or a fragment thereof.
  • a “vector” is a replicon, such as plasmid, phage or cosmid, to which another DNA segment may be attached so as to bring about the replication of the attached segment.
  • a “DNA molecule” refers to the polymeric form of deoxyribonucleotides (adenine, guanine, thymine, or cytosine) in either single stranded form, or a double-stranded helix. This term refers only to the primary and secondary structure of the molecule, and does not limit it to any particular tertiary forms. Thus, this term includes double-stranded DNA found, inter alia, in linear DNA molecules (e.g., restriction fragments), viruses, plasmids, and chromosomes.
  • linear DNA molecules e.g., restriction fragments
  • viruses e.g., plasmids, and chromosomes.
  • the term “gene” shall mean a region of DNA encoding a polypeptide chain.
  • RNA or “mRNA” shall mean an RNA molecule that encodes for one or more polypeptides.
  • DNA polymerase shall mean an enzyme which catalyzes the polymerization of deoxyribonucleotide triphosphates to make DNA chains using a DNA template.
  • Reverse transcriptase shall mean an enzyme which catalyzes the polymerization of deoxy- or ribonucleotide triphosphates to make DNA or RNA chains using an RNA or DNA template.
  • Complementary DNA or “cDNA” shall mean the DNA molecule synthesized by polymerization of deoxyribonucleotides by an enzyme with reverse transcriptase activity.
  • An “isolated nucleic acid” is a nucleic acid the structure of which is not identical to that of any naturally occurring nucleic acid or to that of any fragment of a naturally occurring genomic nucleic acid spanning more than three separate genes.
  • the term therefore covers, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule but is not flanked by both of the coding sequences that flank that part of the molecule in the genome of the organism in which it naturally occurs; (b) a nucleic acid incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e
  • Oligonucleotide as used herein in referring to the probes or primers of the present invention, is defined as a molecule comprised of two or more deoxy- or ribonucleotides, preferably more than ten. Its exact size will depend upon many factors which, in turn, depend upon the ultimate function and use of the oligonucleotide.
  • DNA fragment includes polynucleotides and/or oligonucleotides and refers to a plurality of joined nucleotide units formed from naturally-occurring bases and cyclofuranosyl groups joined by native phosphodiester bonds. This term effectively refers to naturally-occurring species or synthetic species formed from naturally-occurring subunits. “DNA fragment” also refers to purine and pyrimidine groups and moieties which function similarly but which have non naturally-occurring portions. Thus, DNA fragments may have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species. They may also contain altered base units or other modifications, provided that biological activity is retained.
  • DNA fragments may also include species which include at least some modified base forms.
  • purines and pyrimidines other than those normally found in nature may be so employed.
  • modifications on the cyclofuranose portions of the nucleotide subunits may also occur as long as biological function is not eliminated by such modifications.
  • Primer shall refer to an oligonucleotide, whether occurring naturally or produced synthetically, which is capable of acting as a point of initiation of synthesis when placed under conditions in which synthesis of a primer extension product, which is complementary to a nucleic acid strand, is induced, i.e., in the presence of nucleotides and an inducing agent such as a DNA polymerase and at a suitable temperature and pH.
  • the primer may be either single-stranded or double-stranded and must be sufficiently long to prime the synthesis of the desired extension product in the presence of the inducing agent. The exact length of the primer will depend upon many factors, including temperature, the source of primer and the method used. For example, for diagnostic applications, depending on the complexity of the target sequence, the oligonucleotide primer typically contains 10-25 or more nucleotides, although it may contain fewer nucleotides.
  • the primers herein are selected to be “substantially” complementary to different strands of a particular target DNA sequence. This means that the primers must be sufficiently complementary to hybridize with their respective strands. Therefore, the primer sequence need not reflect the exact sequence of the template. For example, a non-complementary nucleotide fragment may be attached to the 5′ end of the primer, with the remainder of the primer sequence being complementary to the strand. Alternatively, non-complementary bases or longer sequences can be interspersed into the primer, provided that the primer sequence has sufficient complementarity with the sequence or hybridize therewith and thereby form the template for the synthesis of the extension product.
  • hybridization refers generally to a technique wherein denatured RNA or DNA is combined with complementary nucleic acid sequence which is either free in solution or bound to a solid phase. As recognized by one skilled in the art, complete complementarity between the two nucleic acid sequences is not a pre-requisite for hybridization to occur. The technique is ubiquitous in molecular genetics and its use centers around the identification of particular DNA or RNA sequences within complex mixtures of nucleic acids.
  • restriction endonucleases and “restriction enzymes” shall refer to bacterial enzymes which cut double-stranded DNA at or near a specific nucleotide sequence.
  • Polypeptide refers to any peptide generated from CA125 either by proteolytic cleavage or chemical cleavage.
  • “Degenerate variant” refers to any amino acid variation in the repeat sequence, which fulfills the homology exon structure and conserved sequences and is recognized by the M11, OC125 and ISOBM series of antibodies.
  • “Fragment” refers to any part of the CA125 molecule identified in a purification scheme.
  • Constant variant antibody shall mean any antibody that fulfills the criteria of M11, OC125 or any of the ISOBM antibody series.
  • “Homology” refers to similarity based on identical base matches in alignment. When two sequences are identical there is a 100% homology, as base matches differ in alignment the homology between two sequences is reduced.
  • the CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified.
  • the genomic DNA for the CA125 gene is set out in SEQ ID NO: 4.
  • the CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain.
  • the amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues.
  • an amino terminal extension is present, which comprises four genomic exons.
  • the amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain.
  • the molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure.
  • the repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding.
  • the repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli.
  • the CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail.
  • the carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule.
  • Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen.
  • the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.
  • the DNA sequences of the present invention can also be characterized as encoding the amino acid sequence equivalents of the amino acid sequence, equivalents, as used in this context, include peptides of substantially similar length and amino acid identity to those disclosed, but having conservative amino acid substitution at a non-critical residue position.
  • a conservative amino acid substitution is a substitution in which an amino acid residue is replaced with an amino acid residue of differing identity, but whose R group can be characterized by chemically similar.
  • Four common categories include: polor but uncharged R groups; positively charged R groups; negatively charged R groups; and, hydrophobic R groups.
  • a preferred conservative substitution involves the substitution of a second hydrophobic residue for a fir hydrophobic residue, the first and second hydrophobic residues differing primarily in the size of the R group.
  • the hydrophobic residue would be predicted to be located internally in the folded pepetide structure and the mild pertubatim caused only by a change in the size of an R group at an internally located which would not alter the antigenecity of R protein.
  • two nucleic acid molecules are substantially equivalent if they have at least about 70% homology.
  • the isolated cDNA sequences (Table 4 and SEQ ID NO: 4) of the present invention can be inserted into an expression vector.
  • Such vectors contain all necessary regulatory signals to promote the expression of a DNA sequence of interest.
  • Expression vectors are typically either prokaryote or eukaryote specific. Expression vectors can be introduced into either prokaryote or eukaryote cells to produce CA125 proteins or portions thereof.
  • the isolated cDNA sequence as shown in Table 4 was expressed to provide the CA125 molecule set out in Table 5 and SEQ ID NO: 5.
  • the expressed CA125 is a polypeptide with the amino acid sequence set forth in SEQ ID NO: 5; an amino acid sequence having at least 50% sequence identity to the sequence, a conservative for variant or a fragment of any of the above. Two polypeptide sequences are substantially equivalent if there is at least 50% sequence homology and substantial similar physical characteristics. However, in practice, a portion of an isolated nucleic acid molecule set out in SEQ ID NO: 4 is expressed to obtain a fragment of the CA125 molecule. This fragment is then purified to obtain an isolated CA125 fragment.
  • purified refers to a polypeptide composition which has been subjected to fractionation to remove various nonprotein components such as other cellular components.
  • Various techniques suitable for use in protein purification are known to those skilled in the relevant art. These techniques include, for example, precipitation with ammonium sulphate, PEG, antibodies and the like or by heat denaturation, followed by centrifugation; chromatography steps such as ion exchange, gel filtration, reverse phase, hydroxylapatite and affinity chromatography; isoelectric focusing; gel electrophoresis; and combination of such techniques.
  • a “purification scheme” is a technique or system to remove various nonprotein components such as other cellular components from the expressed protein.
  • cDNA is expressed with the use of an expression vector.
  • An expression vector is a carrying vector that has an inducer for expression built into the vector. Different vectors use different inducers.
  • the cDNA is ligased into the expression vector using restriction digest sites designed in the vector. The cDNA must be ligased in the sense direction and in the correct reading frame for expression to occur. Once the cDNA is ligased into the expression vector, the construct is transformed into a cell.
  • E-Coli bacteria we use E-Coli bacteria, but the transformation can be done with yeast, mammalian cells, plants cells, etc.
  • the transformed cells are then grown in culture and protein production is induced with the an inducing agent for the expression vector.
  • some expression vectors add tags to the recombinant protein to aid in purification. For example, pQE-30 adds a His—Tag which binds to nickel to aid in purification. Once cells have been successfully transformed, a small aliquot can be frozen and stored for future use.
  • a cDNA sequence one skilled in the art has an easily renewable source of purified CA125. Portions of this cDNA sequence can be expressed to make CA125 polypeptides and these polypeptides can be used to make monoclonal antibodies. These monoclonal antibodies can be made by one skilled in the art to portions of the protein which heretofore do not have any monoclonal antibodies, such as the amino terminal sequence.
  • the purified antibodies are made by the following process: the recombinant protein is injected into an animal (usually a mouse, but other animals can be used).
  • the animal's B-lymphocytes produce antibodies to the protein.
  • Each activated B lymphocyte forms a clone of cells in spleen or lymph nodes, with each cell of the clone producing identical antibody.
  • These spleen cells are then harvested and fused with myeloma cells to produce hybridomas.
  • These hybridomas are immortal and produce only one type of antibody.
  • the hybridomas are selected from cells that did not fuse by selective media.
  • the hybidomas can then be grown in large quantities to produce large quantities of monoclonal antibodies.
  • CA1 25 offers such potential as a target: 1) Antibodies to CA1 25 epitopes or newly described potential epitopes: Most especially humanized or human antibodies to CA125 which could directly activate the patients' immune system to attack and kill tumor cells. Antibodies could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells. 2) Natural ligands: Under normal circumstances, molecules are bound to the CA125 molecule e.g. a 50 k dalton protein which does not contain CA125 epitopes co-purifies with CA125. Such a molecule, which might have a natural binding affinity for domains on the CA125 molecule, could also be utilized to deliver therapeutic agents to tumor cells.
  • CA125 expression may provide a survival or metastatic advantage to ovarian tumor cells as such antisense oligonucleotide derived from the CA125 sequence could be used to down-regulate the expression of CA125.
  • Antisense therapy could be used in association with a tumor cell delivery system such as described above.
  • Small Molecules Recombinant domains of CA125 also offer the potential to identify small molecules which bind to individual domains of the molecule. Small molecules either from combinatorial chemical libraries or small peptides can also be used as delivery agents or as biological modifiers.
  • CA125 and genomic DNA can be used to develop transgenic animal models and can be used under low stringency conditions, to clone CA125 cDNAs and genomic DNAs of other animal species.
  • the CA125 cDNA can be used to prepare stable transformants.
  • the bacterial cells could be transformed with CA125 cDNA to include these genes.
  • PCR was performed in a reaction mixture consisting of ovarian tumor cDNA derived from 50 ng of mRNA, 5 pmol each of sense and antisense primers for the CA125 repeat, 0.2 mmol of dNTPs, and 0.625 U of Taq polymerase in 1 ⁇ buffer in a final volume of 25 ⁇ l. This mixture was subjected to 1 minute of denaturation at 95° C. followed by 30 cycles of PCR consisting of the following: denaturation for 30 seconds at 95° C., 30 seconds of annealing at 62° C., and 1 minute of extension at 72° C. with an additional 7 minutes of extension on the last cycle.
  • the product was electrophoresed through a 2% agarose gel for separation, the PCR product was purified and digested with the restriction enzymes BamHI and HindIII.
  • This digested PCR product was ligated into the expression vector pQE-30, which had also been digested with BamHI and HindIII.
  • the ligation reaction consisted of 1 ⁇ l of 10 ⁇ ligation buffer, 1 ⁇ l of 10 ⁇ bovine serum albumin (BSA), 1 ⁇ l of T4 ligase enzyme, and 7 ⁇ l of digested PCR product. The reaction went overnight at 15° C. This clone would allow for expression of recombinant amino-terminal 6 ⁇ His-tagged CA125 repeat. The construct was then transformed into JM109 E.
  • the transformation reaction consisted of 5 ⁇ l of ligation reaction and 50 ⁇ l of cells. The reaction was mixed gently and then incubated on ice for 30 minutes. The reaction was then heat shocked at 42° C. for 45 seconds in a water bath before being returned to ice for 2 minutes. 500 ⁇ l of LB broth media were added and the mixture was incubated at 37° C. for 1 hour. At the end of 1 hour the cells were spun down in a microfuge at 4,000 ⁇ g for 5 minutes and approximately 450 ⁇ l of media was removed. The cells were resuspended in the remaining 100 ⁇ l of media, transferred to a LAIX plate, and incubated overnight at 37° C.
  • E. coli were grown in 1L cultures to an OD 600 of 1.5-2.0 at 37° C. and were induced with IPTG (0.1 mM) for 4-6 hours at 25° C. to produce recombinant protein.
  • Whole E. coli lysate was electrophoresed through a denaturing 12% polyacrylamide gel and Coomassie stained to detect highly expressed proteins. His-tagged proteins were purified under denaturing conditions using Ni-NTA agarose metal chelating affinity chromatography available from Qiagen according to the manufacturer's instructions. Cells are spun down to remove liquid LB broth media.
  • the cells are then resuspended in 40 ml of 8M Urea lysis buffer (pH 8.0) and incubated with agitation overnight at room temperature. The mixture is then spun down and the lysate is removed. The lysate is then incubated with Ni-NTA agarose beads with agitation overnight at room temperature. The beads are pelleted and the supernatant is removed. The beads are then washed twice in lysis buffer pH 8.0 plus Triton X, three times with lysis buffer pH 6.3 plus Triton X, and four times with lysis buffer pH 6.3 without Triton X. The protein is then eluted from the beads with lysis buffer pH4.2 plus 25 mM EDTA incubated overnight with agitation at room temperature.
  • 8M Urea lysis buffer pH 8.0
  • the beads are pelleted and the supernatant containing the recombinant protein is removed.
  • the supernatant is then dialyzed twice in 0.2 ⁇ PBS to remove the urea and freeze dried for storage. 1L of culture produced 2.4 mg of recombinant protein.

Abstract

The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.

Description

    BACKGROUND OF THE INVENTION
  • This application is a continuation-in-part of U.S. Provisional Application Serial No. 60/284,175 filed Apr. 17, 2001, U.S. Provisional Application Serial No. 60/299,380 filed Jun. 19, 2001, U.S. Non-Provisional Application No. 09/965,738 filed Sep. 27, 2001, and U.S. Provisional Application Serial No. 60/345,180. This application is a continuation-in-part of provisional application 60/427,045 (filed Nov. 15, 2002), all of which are hereby specifically incorporated by reference. Applicants hereby specifically claims the benefit of these prior filed applications under 35 U.S.C. § 119(e), and 120. [0001]
  • The present invention relates generally to the cloning, identification, and expression of the CA125 gene's glycosylated amino terminal domain, the multiple repeat domain, and the carboxy terminal domain in vitro and, more specifically, to the use of recombinant CA125 with epitope binding sites for diagnostic and therapeutic purposes. Additionally, the genomic DNA, a molecule encoding a 5′ upstream region of CA125 and a genomic DNA sequence for the amino terminal, extra cellular repeats and carboxy terminal of CA125 has been determined. [0002]
  • CA125 is an antigenic determinant located on the surface of ovarian carcinoma cells with essentially no expression in normal adult ovarian tissue. Elevated in the sera of patients with ovarian adenocarcinoma, CA125 has played a critical role for more than 15 years in the management of these patients relative to their response to therapy and also as an indicator of recurrent disease. [0003]
  • It is well established that CA125 is not uniquely expressed in ovarian carcinoma, but is also found in both normal secretory tissues and other carcinomas (i.e., pancreas, liver, colon) [Hardardottir H et al., Distribution of CA125 in embryonic tissue and adult derivatives of the fetal periderm, [0004] Am J Obstet. Gynecol. 163;6(1):1925-1931 (1990); Zurawski V R et al., Tissue distribution and characteristics of the CA125 antigen, Cancer Rev. 11-12:102-108 (1988); and O'Brien T J et al., CA125 antigen in human amniotic fluid and fetal membranes, Am J Obstet Gynecol. 155:50-55, (1986); Nap M et al., Immunohistochemical characterization of 22 monoclonal antibodies against the CA125 antigen: 2nd report from the ISOBM TD-1 workshop, Tumor Biology 17:325-332 (1996)]. Notwithstanding, CA125 correlates directly with the disease status of affected patients (i.e., progression, regression, and no change), and has become the “gold standard” for monitoring patients with ovarian carcinoma [Bast R C et al., A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer, N Engl J Med. 309:883-887 (1983); and Bon G C et al., Serum tumor marker immunoassays in gynecologic oncology: Establishment of reference values, Am J Obstet. Gynecol. 174:107-114 (1996)]. CA125 is especially useful in post-menopausal patients where endometrial tissue has become atrophic and, as a result, is not a major source of normal circulating CA125.
  • During the mid 1980's, the inventor of the present invention and others developed M11, a monoclonal antibody to CA125. M11 binds to a dominant epitope on the repeat structure of the CA125 molecule [O'Brien T J et al., New monoclonal antibodies identify the glycoprotein carrying the CA125 epitope, [0005] Am J Obstet Gynecol 165:1857-64 (1991)]. More recently, the inventor and others developed a purification and stabilization scheme for CA125, which allows for the accumulation of highly purified high molecular weight CA125 [O'Brien T J et al., More than 15 years of CA125: What is known about the antigen, its structure and its function, Int J Biological Markers 13(4):188-195 (1998)].
  • Considerable progress has been made over the years to further characterize the CA125 molecule, its structure and its function. The CA125 molecule is a high molecular weight glycoprotein with a predominance of O-linked sugar side chains. The native molecule exists as a very large complex (˜2-5 million daltons). The complex appears to be composed of an epitope containing CA125 molecule and binding proteins which carry no CA125 epitopes. The CA125 molecule is heterogenous in both size and charge, most likely due to continuous deglycosylation of the side chains during its life-span in bodily fluids. The core CA125 subunit is in excess of 200,000 daltons, and retains the capacity to bind both OC125 and M11 class antibodies. [0006]
  • Despite the advances in detection and quantitation of serum tumor markers like CA125, the majority of ovarian cancer patients are still diagnosed at an advanced stage of the disease—Stage III or IV. Further, the management of patients' responses to treatment and the detection of disease recurrence remain major problems. There, thus, remains a need to significantly improve and standardize current CA125 assay systems. Further, the development of an early indicator of risk of ovarian cancer will provide a useful tool for early diagnosis and improved prognosis. [0007]
    • SUMMARY OF THE INVENTION
  • Thus, it is an object of the present invention to provide a recombinant CA125 cDNA molecule which can be introduced into animals or human cells to achieve transcription or expression of the cDNA. The utility of knowing the DNA sequence of a specific gene is that a recombinant protein can be produced which can be used as an easily renewable source of that gene or a portion of the gene. Producing and purifying recombinant protein is easier and can produce greater quantities of protein than purifying native protein from patients. The recombinant protein can then be used to produce antibodies to the gene, both polyclonal and monoclonal. The recombinant protein can also be used as a positive control in test kits and experiments. [0008]
  • The genomic sequence for CA125 and a 5′ upstream region has been determined. A DNA sequence showing the 5′ upstream region and the amino terminal portion of the CA125 molecule is set out in Table 1 and SEQ ID NO: 1. The extracellular amino terminal domain is made of exons: Exon 1 from 2205-11679; Exon 2 from 13464-13570; Exon 3 from 16177-34419; Exon 4 from 34575-38024; Exon 5 from 38689-38800; Exon 6 from 40578-45257; Exon 7 from 47360-47395; Exon 8 from 52407-52442; Exon 9 from 52686-52744 as set out in SEQ ID NO: 1. A DNA sequence showing the extracellular repeat portion of the CA125 molecule is set out in Table 2 and SEQ ID NO: 2. The genomic repeats are made of exons: Exon R1 from 1-130; Exon R2 from 442-510; Exon R3 from 5479-5652; Exon R4 from 6301-6334; Exon R5 from 6593-6657; Exon R1 from 7558-7683; Exon R from 8216-8284; Exon R3 from 8877-9050; Exon R4 from 9380-9413; Exon R5 from 9675-9739; Exon R1 from 10201-10291; Exon R2 from 10524-10592; Exon R3 from 11200-11373; Exon R4 from 11722-11755; Exon R5 from 12016-12036; Exon R1 from 12169-12295; Exon R2 from 12532-12600; Exon R3 from 13219-13392; Exon R4 from 13723-13756; Exon R5 from 14016-14077; Exon R1 from 15001-15126; Exon R2 from 15367-15435; Exon R1 from 15648-15773; Exon R2 from 16002-16070; Exon R3 from 16653-16826; Exon R4 from 17158-17191; Exon R5 from 17453-17517; Exon R1 from 18532-18657; Exon R2 from 18888-18956; Exon R3 from 19633-19806; Exon R4 from 20141-20176; Exon R5 from 20387-20449; Exon R1 from 21609-21731; Exon R2 from 21940-22008; Exon R3 from 22605-22778; Exon R4 from 23109-23142; Exon R1 from 29046-29168; Exon R2 from 29266-29334; Exon R3 from 33917-34090; Exon R4 from 36702-36734; Exon R5 from 38270-38320;Exon R1 from 39104-39224; Exon R2 from 39315-39383; Exon R3 from 39532-39705; Exon R4 from 41862-41992. A DNA sequence showing the carboxy terminal domain of the CA125 molecule is set out in Table 3 and SEQ ID NO: 3. The carboxy terminal portion is made of exons: Exon Cl from 1-66; Exon C2 from 1802-1947; Exon C3 from 4198-4350; Exon C4 from 4679-4747; Exon C5 from 6811-6978; Exon C6 from 11232-11270; Exon C7 from 11594-11677; Exon C8 from 14095-14187 as set out in SEQ ID NO: 3. A full length cDNA molecule for CA125 is set out in Table 4 and SEQ ID NO: 4. A CA125 protein is set out in Table 5 and SEQ ID NO: 5. [0009]
  • Now that the DNA sequence which encodes CA125 has been discovered known synthetic methods can be employed to prepare DNA molecules containing portions of the sequence. Conventional cloning vehicles, such as plasmids, viruses, or bacteria phages can be modified using known methods so as to produce novel cloning vehicles which contain cDNA encoding, CA125, analogs or mutants thereof. Similarly, such cloning vehicles can be modified or engineered so that they contain DNA molecules from Table 4 and SEQ ID NO: 4 or segments substantially similar thereto. The DNA molecule inserted may be made by various methods including enzymatic or chemical synthesis. [0010]
  • The CA125 gene has been cloned and multiple repeat sequences as well as the glycosylated amino terminal and the carboxy terminus have been identified. CA125 requires a transcript of more than 35,000 bases and occupies approximately 150,000 bp on chromosome 19p 13.2. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. Analysis of the amino terminal extension revealed that its amino acid composition is consistent with the amino acid composition of the amino terminal domain. [0011]
  • Perhaps even more significantly, the multiple repeat domains of CA125 or other domains could also be used for the development of a potential vaccine for patients with ovarian cancer. In order to induce cellular and humoral immunity in humans to CA125, murine antibodies specific for CA125 were utilized in anticipation of patient production of anti-ideotypic antibodies, thus indirectly allowing the induction of an immune response to the CA125 molecule. With the availability of recombinant CA125, especially domains which encompass epitope binding sites for known murine antibodies, it will be feasible to more directly stimulate patients' immune systems to CA125 and, as a result, extend the life of ovarian carcinoma patients. [0012]
  • The recombinant CA125 of the present invention may also be used to develop therapeutic targets. Molecules like CA125, which are expressed on the surface of tumor cells, provide potential targets for immune stimulation, drug delivery, biological modifier delivery or any agent which can be specifically delivered to ultimately kill the tumor cells. Humanized or human antibodies to CA125 epitopes could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells. Natural ligands having a natural binding affinity for domains on the CA125 molecule could also be utilized to deliver therapeutic agents to tumor cells. [0013]
  • CA125 expression may further provide a survival or metastatic advantage to ovarian tumor cells. Antisense oligonucleotides derived from the CA125 repeat sequences could be used to down-regulate the expression of CA125. Further, antisense therapy could be used in association with a tumor cell delivery system of the type described above. [0014]
  • Recombinant domains of the CA125 molecule also have the potential to identify small molecules, which bind to individual domains of the CA125 molecule. These small molecules could also be used as delivery agents or as biological modifiers. [0015]
  • In another aspect of the present invention, an isolated nucleic acid of the CA125 gene is disclosed, which comprises a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequences set forth in SEQ ID NOS: 1, 2, 3 and 4; (b) a nucleotide sequence having at least 70% sequence identity to any one of the sequences in (a); (c) a degenerate variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c). [0016]
  • In another aspect of the present invention, an isolated nucleic acid of the CA125 gene, comprising a sequence that encodes a polypeptide with the amino acid sequence selected from the group consisting of: (a) the amino acid sequences set forth in SEQ ID NO: 5; (b) an amino acid sequence having at least 50% sequence identity to any one of the sequences in (a); (c) a conservative variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c). [0017]
  • The vector may be a cloning vector, a shuttle vector, or an expression vector. A cultured cell comprising the vector is also contemplated. [0018]
  • More specifically, this invention relates to a purified antibody that selectively binds to an epitope in the CA125 protein of SEQ ID NO: 5. Similarly, the purified antibody selectively binds to an amino acid sequence having at least 50% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 60% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 70% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 80% sequence identity to said sequence; and the purified antibody selectively binds to an amino acid sequence having at least 90% sequence identity to said sequence. Additionally, purified antibody can be a conservative variant of the amino acid sequence set forth in SEQ ID NO: 5 or a fragment thereof. [0019]
    • DETAILED DESCRIPTION OF THE INVENTION
  • In accordance with the present invention, conventional molecular biology, microbiology, and recombinant DNA techniques may be used that will be apparent to those skilled in the relevant art. Such techniques are explained fully in the literature (see, e.g., Maniatis, Fritsch & Sambrook, “Molecular Cloning: A Laboratory Manual (1982); “DNA Cloning: A Practical Approach,” Volumes I and II (D. N. Glover ed. 1985); “Oligonucleotide Synthesis” (M. J. Gait ed. 1984); “Nucleic Acid Hybridization” (B. D. Hames & S. J. Higgins eds. (1985)); “Transcription and Translation” (B. D. Hames & S. J. Higgins eds. (1984)); “Animal Cell Culture” (R. I. Freshney, ed. (1986)); “Immobilized Cells And Enzymes” (IRL Press, (1986)); and B. Perbal, “A Practical Guide To Molecular Cloning” (1984)). [0020]
  • Therefore, if appearing herein, the following terms shall have the definitions set out below. [0021]
  • A “vector” is a replicon, such as plasmid, phage or cosmid, to which another DNA segment may be attached so as to bring about the replication of the attached segment. [0022]
  • A “DNA molecule” refers to the polymeric form of deoxyribonucleotides (adenine, guanine, thymine, or cytosine) in either single stranded form, or a double-stranded helix. This term refers only to the primary and secondary structure of the molecule, and does not limit it to any particular tertiary forms. Thus, this term includes double-stranded DNA found, inter alia, in linear DNA molecules (e.g., restriction fragments), viruses, plasmids, and chromosomes. [0023]
  • As used herein, the term “gene” shall mean a region of DNA encoding a polypeptide chain. [0024]
  • “Messenger RNA” or “mRNA” shall mean an RNA molecule that encodes for one or more polypeptides. [0025]
  • “DNA polymerase” shall mean an enzyme which catalyzes the polymerization of deoxyribonucleotide triphosphates to make DNA chains using a DNA template. [0026]
  • “Reverse transcriptase” shall mean an enzyme which catalyzes the polymerization of deoxy- or ribonucleotide triphosphates to make DNA or RNA chains using an RNA or DNA template. [0027]
  • “Complementary DNA” or “cDNA” shall mean the DNA molecule synthesized by polymerization of deoxyribonucleotides by an enzyme with reverse transcriptase activity. [0028]
  • An “isolated nucleic acid” is a nucleic acid the structure of which is not identical to that of any naturally occurring nucleic acid or to that of any fragment of a naturally occurring genomic nucleic acid spanning more than three separate genes. The term therefore covers, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule but is not flanked by both of the coding sequences that flank that part of the molecule in the genome of the organism in which it naturally occurs; (b) a nucleic acid incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion protein. [0029]
  • “Oligonucleotide”, as used herein in referring to the probes or primers of the present invention, is defined as a molecule comprised of two or more deoxy- or ribonucleotides, preferably more than ten. Its exact size will depend upon many factors which, in turn, depend upon the ultimate function and use of the oligonucleotide. [0030]
  • “DNA fragment” includes polynucleotides and/or oligonucleotides and refers to a plurality of joined nucleotide units formed from naturally-occurring bases and cyclofuranosyl groups joined by native phosphodiester bonds. This term effectively refers to naturally-occurring species or synthetic species formed from naturally-occurring subunits. “DNA fragment” also refers to purine and pyrimidine groups and moieties which function similarly but which have non naturally-occurring portions. Thus, DNA fragments may have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species. They may also contain altered base units or other modifications, provided that biological activity is retained. DNA fragments may also include species which include at least some modified base forms. Thus, purines and pyrimidines other than those normally found in nature may be so employed. Similarly, modifications on the cyclofuranose portions of the nucleotide subunits may also occur as long as biological function is not eliminated by such modifications. [0031]
  • “Primer” shall refer to an oligonucleotide, whether occurring naturally or produced synthetically, which is capable of acting as a point of initiation of synthesis when placed under conditions in which synthesis of a primer extension product, which is complementary to a nucleic acid strand, is induced, i.e., in the presence of nucleotides and an inducing agent such as a DNA polymerase and at a suitable temperature and pH. The primer may be either single-stranded or double-stranded and must be sufficiently long to prime the synthesis of the desired extension product in the presence of the inducing agent. The exact length of the primer will depend upon many factors, including temperature, the source of primer and the method used. For example, for diagnostic applications, depending on the complexity of the target sequence, the oligonucleotide primer typically contains 10-25 or more nucleotides, although it may contain fewer nucleotides. [0032]
  • The primers herein are selected to be “substantially” complementary to different strands of a particular target DNA sequence. This means that the primers must be sufficiently complementary to hybridize with their respective strands. Therefore, the primer sequence need not reflect the exact sequence of the template. For example, a non-complementary nucleotide fragment may be attached to the 5′ end of the primer, with the remainder of the primer sequence being complementary to the strand. Alternatively, non-complementary bases or longer sequences can be interspersed into the primer, provided that the primer sequence has sufficient complementarity with the sequence or hybridize therewith and thereby form the template for the synthesis of the extension product. [0033]
  • As used herein, the term “hybridization” refers generally to a technique wherein denatured RNA or DNA is combined with complementary nucleic acid sequence which is either free in solution or bound to a solid phase. As recognized by one skilled in the art, complete complementarity between the two nucleic acid sequences is not a pre-requisite for hybridization to occur. The technique is ubiquitous in molecular genetics and its use centers around the identification of particular DNA or RNA sequences within complex mixtures of nucleic acids. [0034]
  • As used herein, “restriction endonucleases” and “restriction enzymes” shall refer to bacterial enzymes which cut double-stranded DNA at or near a specific nucleotide sequence. [0035]
  • “Purified polypeptide” refers to any peptide generated from CA125 either by proteolytic cleavage or chemical cleavage. [0036]
  • “Degenerate variant” refers to any amino acid variation in the repeat sequence, which fulfills the homology exon structure and conserved sequences and is recognized by the M11, OC125 and ISOBM series of antibodies. [0037]
  • “Fragment” refers to any part of the CA125 molecule identified in a purification scheme. [0038]
  • “Conservative variant antibody” shall mean any antibody that fulfills the criteria of M11, OC125 or any of the ISOBM antibody series. [0039]
  • “Homology” refers to similarity based on identical base matches in alignment. When two sequences are identical there is a 100% homology, as base matches differ in alignment the homology between two sequences is reduced. [0040]
  • The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The genomic DNA for the CA125 gene is set out in SEQ ID NO: 4. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in [0041] E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.
  • The DNA sequences of the present invention can also be characterized as encoding the amino acid sequence equivalents of the amino acid sequence, equivalents, as used in this context, include peptides of substantially similar length and amino acid identity to those disclosed, but having conservative amino acid substitution at a non-critical residue position. A conservative amino acid substitution is a substitution in which an amino acid residue is replaced with an amino acid residue of differing identity, but whose R group can be characterized by chemically similar. Four common categories include: polor but uncharged R groups; positively charged R groups; negatively charged R groups; and, hydrophobic R groups. A preferred conservative substitution involves the substitution of a second hydrophobic residue for a fir hydrophobic residue, the first and second hydrophobic residues differing primarily in the size of the R group. The hydrophobic residue would be predicted to be located internally in the folded pepetide structure and the mild pertubatim caused only by a change in the size of an R group at an internally located which would not alter the antigenecity of R protein. More specifically, two nucleic acid molecules are substantially equivalent if they have at least about 70% homology. [0042]
  • The isolated cDNA sequences (Table 4 and SEQ ID NO: 4) of the present invention can be inserted into an expression vector. Such vectors contain all necessary regulatory signals to promote the expression of a DNA sequence of interest. Expression vectors are typically either prokaryote or eukaryote specific. Expression vectors can be introduced into either prokaryote or eukaryote cells to produce CA125 proteins or portions thereof. The isolated cDNA sequence as shown in Table 4 was expressed to provide the CA125 molecule set out in Table 5 and SEQ ID NO: 5. The expressed CA125 is a polypeptide with the amino acid sequence set forth in SEQ ID NO: 5; an amino acid sequence having at least 50% sequence identity to the sequence, a conservative for variant or a fragment of any of the above. Two polypeptide sequences are substantially equivalent if there is at least 50% sequence homology and substantial similar physical characteristics. However, in practice, a portion of an isolated nucleic acid molecule set out in SEQ ID NO: 4 is expressed to obtain a fragment of the CA125 molecule. This fragment is then purified to obtain an isolated CA125 fragment. [0043]
  • In certain embodiments, “purified” refers to a polypeptide composition which has been subjected to fractionation to remove various nonprotein components such as other cellular components. Various techniques suitable for use in protein purification are known to those skilled in the relevant art. These techniques include, for example, precipitation with ammonium sulphate, PEG, antibodies and the like or by heat denaturation, followed by centrifugation; chromatography steps such as ion exchange, gel filtration, reverse phase, hydroxylapatite and affinity chromatography; isoelectric focusing; gel electrophoresis; and combination of such techniques. Similarly, a “purification scheme” is a technique or system to remove various nonprotein components such as other cellular components from the expressed protein. Various techniques suitable for use in protein purification are known to those skilled in the relevant art. These techniques include, for example, precipitation with ammonium sulphate, PEG, antibodies and the like or by heat denaturation, followed by centrifugation; chromatography steps such as ion exchange, gel filtration, reverse phase, hydroxylapatite and affinity chromatography; isoelectric focusing; gel electrophoresis; and combination of such techniques. [0044]
  • The genomic DNA and a full-length cDNA sequence of human CA125 has been determined. Additionally, a nucleic acid molecule encoding a 5′ upstream region of the CA125 gene has been determined. cDNA is expressed with the use of an expression vector. An expression vector is a carrying vector that has an inducer for expression built into the vector. Different vectors use different inducers. The cDNA is ligased into the expression vector using restriction digest sites designed in the vector. The cDNA must be ligased in the sense direction and in the correct reading frame for expression to occur. Once the cDNA is ligased into the expression vector, the construct is transformed into a cell. In the preferred embodiment, we use [0045] E-Coli bacteria, but the transformation can be done with yeast, mammalian cells, plants cells, etc. The transformed cells are then grown in culture and protein production is induced with the an inducing agent for the expression vector. In the preferred embodiment, we use the pQE-30 expression vector and induce with IPTG. Once induction has occurred, the cells are harvested and the protein is purified. It should be noted that some expression vectors add tags to the recombinant protein to aid in purification. For example, pQE-30 adds a His—Tag which binds to nickel to aid in purification. Once cells have been successfully transformed, a small aliquot can be frozen and stored for future use.
  • With a cDNA sequence, one skilled in the art has an easily renewable source of purified CA125. Portions of this cDNA sequence can be expressed to make CA125 polypeptides and these polypeptides can be used to make monoclonal antibodies. These monoclonal antibodies can be made by one skilled in the art to portions of the protein which heretofore do not have any monoclonal antibodies, such as the amino terminal sequence. [0046]
  • More specifically, the purified antibodies are made by the following process: the recombinant protein is injected into an animal (usually a mouse, but other animals can be used). The animal's B-lymphocytes produce antibodies to the protein. Each activated B lymphocyte forms a clone of cells in spleen or lymph nodes, with each cell of the clone producing identical antibody. These spleen cells are then harvested and fused with myeloma cells to produce hybridomas. These hybridomas are immortal and produce only one type of antibody. The hybridomas are selected from cells that did not fuse by selective media. The hybidomas can then be grown in large quantities to produce large quantities of monoclonal antibodies. [0047]
  • Therapeutic Targets: Molecules, which are expressed on the surface of tumor cells as CA125 is, offer potential targets for immune stimulation, drug delivery, biological modifier delivery or any agent which can be specifically delivered to ultimately kill the tumor cells. CA1 25 offers such potential as a target: 1) Antibodies to CA1 25 epitopes or newly described potential epitopes: Most especially humanized or human antibodies to CA125 which could directly activate the patients' immune system to attack and kill tumor cells. Antibodies could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells. 2) Natural ligands: Under normal circumstances, molecules are bound to the CA125 molecule e.g. a 50 k dalton protein which does not contain CA125 epitopes co-purifies with CA125. Such a molecule, which might have a natural binding affinity for domains on the CA125 molecule, could also be utilized to deliver therapeutic agents to tumor cells. [0048]
  • Anti-sense therapy: CA125 expression may provide a survival or metastatic advantage to ovarian tumor cells as such antisense oligonucleotide derived from the CA125 sequence could be used to down-regulate the expression of CA125. Antisense therapy could be used in association with a tumor cell delivery system such as described above. [0049]
  • Small Molecules: Recombinant domains of CA125 also offer the potential to identify small molecules which bind to individual domains of the molecule. Small molecules either from combinatorial chemical libraries or small peptides can also be used as delivery agents or as biological modifiers. [0050]
  • Transgenic Animals/Transformed: CA125 and genomic DNA can be used to develop transgenic animal models and can be used under low stringency conditions, to clone CA125 cDNAs and genomic DNAs of other animal species. The CA125 cDNA can be used to prepare stable transformants. The bacterial cells could be transformed with CA125 cDNA to include these genes.[0051]
    • EXAMPLE 1
  • Expression of 6×His-tagged CA125 repeat in [0052] E. coli: The open reading frame of the CA125 repeat was amplified by PCR with the 5′ sense primer 1 (5′-ACCGGATCCATGGGCCACACAGAGCCTGGCCC-3′) (SEQ ID NO: 6) and the 3′ antisense primer 2 (5′-TGTAAGCTTAGGCAGGGAGGATGGAGTCC-3′) (SEQ ID NO: 7). The open reading frame of the CA125 repeat constitutes a portion of the isolated nucleic acid molecule set out in SEQ ID NO: 4. PCR was performed in a reaction mixture consisting of ovarian tumor cDNA derived from 50 ng of mRNA, 5 pmol each of sense and antisense primers for the CA125 repeat, 0.2 mmol of dNTPs, and 0.625 U of Taq polymerase in 1× buffer in a final volume of 25 μl. This mixture was subjected to 1 minute of denaturation at 95° C. followed by 30 cycles of PCR consisting of the following: denaturation for 30 seconds at 95° C., 30 seconds of annealing at 62° C., and 1 minute of extension at 72° C. with an additional 7 minutes of extension on the last cycle. The product was electrophoresed through a 2% agarose gel for separation, the PCR product was purified and digested with the restriction enzymes BamHI and HindIII. This digested PCR product was ligated into the expression vector pQE-30, which had also been digested with BamHI and HindIII. The ligation reaction consisted of 1 μl of 10× ligation buffer, 1 μl of 10× bovine serum albumin (BSA), 1 μl of T4 ligase enzyme, and 7 μl of digested PCR product. The reaction went overnight at 15° C. This clone would allow for expression of recombinant amino-terminal 6×His-tagged CA125 repeat. The construct was then transformed into JM109 E. coli cells. The transformation reaction consisted of 5 μl of ligation reaction and 50 μl of cells. The reaction was mixed gently and then incubated on ice for 30 minutes. The reaction was then heat shocked at 42° C. for 45 seconds in a water bath before being returned to ice for 2 minutes. 500 μl of LB broth media were added and the mixture was incubated at 37° C. for 1 hour. At the end of 1 hour the cells were spun down in a microfuge at 4,000×g for 5 minutes and approximately 450 μl of media was removed. The cells were resuspended in the remaining 100 μl of media, transferred to a LAIX plate, and incubated overnight at 37° C. White colonies were picked from the plate and cultured in 5 ml LB broth media to determine if the transformation was successful. Transformed E. coli were grown in 1L cultures to an OD600 of 1.5-2.0 at 37° C. and were induced with IPTG (0.1 mM) for 4-6 hours at 25° C. to produce recombinant protein. Whole E. coli lysate was electrophoresed through a denaturing 12% polyacrylamide gel and Coomassie stained to detect highly expressed proteins. His-tagged proteins were purified under denaturing conditions using Ni-NTA agarose metal chelating affinity chromatography available from Qiagen according to the manufacturer's instructions. Cells are spun down to remove liquid LB broth media. The cells are then resuspended in 40 ml of 8M Urea lysis buffer (pH 8.0) and incubated with agitation overnight at room temperature. The mixture is then spun down and the lysate is removed. The lysate is then incubated with Ni-NTA agarose beads with agitation overnight at room temperature. The beads are pelleted and the supernatant is removed. The beads are then washed twice in lysis buffer pH 8.0 plus Triton X, three times with lysis buffer pH 6.3 plus Triton X, and four times with lysis buffer pH 6.3 without Triton X. The protein is then eluted from the beads with lysis buffer pH4.2 plus 25 mM EDTA incubated overnight with agitation at room temperature. The beads are pelleted and the supernatant containing the recombinant protein is removed. The supernatant is then dialyzed twice in 0.2× PBS to remove the urea and freeze dried for storage. 1L of culture produced 2.4 mg of recombinant protein.
  • It should be understood that various changes and modifications to the presently preferred embodiments described herein will be apparent to those skilled in the art. Such changes and modifications can be made without departing from the spirit and scope of the present invention and without diminishing its attendant advantages. [0053]
    TABLE 1
    Genomic CA125 Amino Terminal Sequence
    (SEQ ID NO: 1)
      1 GGTGCGCACC ACTATGTCTG GCTAATTTTT GTATTTTTTT GTAGAGACAT
      51 GGTTTCACCA TGTTGGCCAG GCTGGTCTCG AATTCCTGAC TTCAAGTAAT
     101 CCACCCACCT CAGCCTCCCA AAGTGCTGGG ATTACAAGCA TGAGCCACCA
     151 TGCATGGCCT AAAGCTTCTT TTAAAGCCAC CAAGTCCCTT CCCATGTTAG
     201 CCCACTAATC CATGGGTTAG TCATGAATGG ATTAATCTAT TCATACGGAC
     251 AGAGCCCTCA TCACCCAATC ACCTCTTAAA GGCCCCACCT CTCAATACTG
     301 CCACACTGGG GATTAAGTTT CAACAGAGTT TTGGAGGGGA CATTCAAATC
     351 ATAGTAATGC CCAAAGTGAA AAATCTTCCC TGCACTTTTC CCTCAACAAA
     401 AACAGCCAGA GATAGTGAGC TGCCAGGAAA TTCTTTTTTT TTTCCTCTTC
     451 TGTCCTAAAT CAGCATCGCT AGACCTTTAC ATGATTCAAC CTCATCTTCT
     501 TCACCCTCTG GGTCATGAAA TTTTATTTAT TTATTTATTA TTTTCTTGGG
     551 ACAGACTCTG GCTCTGTCGC CCAGGCTGAA GTGCAGTGGT GTGATCTTGG
     601 CTCACTGCAA CCTCCGCCTC CCGGGTTCAA GCGATTCTCC TGCCTCAGCC
     651 TCCTGAGTAG CTGGGATTAC AGGTGGGCGC CACCACACCC AGCTAATTTT
     701 TTGTATTTTT AGTAGAGATG GGGTTTCACC ATATTAGCCA GGATGGTCTC
     751 CATCTCTTGA CCTCGTGATC TGCCCACCTC AGCCTCCCAA AATGCTGGGA
     801 TTACAGGCAT GAGACACCAC GCCCAGCAGG CCAGGGTCAT GAGATTTTAA
     851 TCAAGAGCAA CTTCCACTGA TTCCTGAGAG TGCATCTGTG GGCCCCTGCT
     901 CTGATCTGAA CAGAAGTGCC GTGTCTTCTC TGACCTCCAC TTCTCAATTC
     951 AAGAGCCTTA GTATCTGCCA GTATCACACA CTGAGCATTA GCTCCATCTC
     1001 ATGGGGGTGT AGGTAGGGGC TCTATCTGCA TCTTTCTTTC TTTTTTTCTT
     1051 TCTTTCCCTT CCTCCCTTCC TCACTCCCTC GGTCCTCTCT TTCTTTCCTT
     1101 TTCTTTCTTC CTTCCTCCCT TCCTCCCTCC CTCCCTCTCT CTTTCTCTCT
     1151 TTCTTTCTTT CCTTCTTTCT TTCTTTCTCT CTTCCTTCCC TCCCTCCCTC
     1201 CTTCCTTCCT TTCTCTTTCT TTCTCTTTCT TTCTTTTTTT CCTTCCTTCC
     1251 TTCCTTCTTT CTCTTTCTCT CCCTCCCTTC CTTCCTTCCT TCCTTCCTTC
     1301 CTTCCTTTCT TTCTTTCTTT CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT
     1351 TTCTTTCTTC CTTCCTTCCT TCCTTCCTTC CTTCCTTCCT TCCTTCCTTT
     1401 CTTTTCTTTC TTTCTCTTTC TTTTTGAGAC AGAGCTCTTA TTACCCATGC
     1451 TGGAGTGCAG TGGTGTGACC TTGGCTTACT GCAACATCTG CCTCCTAGGG
     1501 TCAAGTGATT CTCCTGCCTC AGCCTCCTAA GTAGCTGGGA TTACAGACAC
     1551 ATGCCACCAC ACCCAATATT TATTTTTATT AAAATTTTTT TTAAAATTAT
     1601 TTTTAAAAAA TTAAAAATAA TTTTGTATTT TTAGTAGAGA CGGGGTTTCT
     1651 CCATGTTGGT CAGGCTGATC TCAAACTCCC AACCTCAGGT GATCCTCCCA
     1701 CCTCACCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CGTGCCCAGC
     1751 CTGGTTCCTG GTTTCTAAGA CATCACACAC ACACACACAC ACACACACAC
     1801 ACACTCACAC ACTCAGAGAG AGAGAGAGAG AGAGGATCAT TAAGACATGA
     1851 TACACTAAGA AATTCTATTC TGCAGACACT GAGAATCCGT TAAAAAGTTT
     1901 GAAGGGAAGA ATTGAGATCA TCAGGTGTTT ATTTGAGGAA ATTGTCTGTG
     1951 GTTGAACTAT CCTTTCCTTT CTCTCCCTGA GATTTGGTCT TCTCAATTAG
     2001 AAGCGTTGCA CAATTCCCCC AACCTCCATA CATACGGCAG CTCTTCTAGA
     2051 CACAGGTTTT CCCAGGTCAA ATGCGGGGAC CCCAGCCATA TCTCCCACCC
     2101 TGAGAAATTT TGGAGTTTCA GGGAGCTCAG AAGCTCTGCA GAGGCCACCC
     2151 TCTCTGAGGG GATTCTTCTT AGACCTCCAT CCAGAGGCAA ATGTTGACCT
    Exon 1
     2201 GTCC ATGCTG AAACCCTCAG GCCTTCCTGG GTCATCTTCT CCCACCCGCT
     2251 CCTTGATGAC AGGGAGCAGG AGCACTAAAG CCACACCAGA AATGGATTCA
     2301 GGACTGACAG GAGCCACCTT GTCACCTAAG ACATCTACAG GTGCAATCGT
     2351 GGTGACAGAA CATACTCTGC CCTTTACTTC CCCAGATAAG ACCTTGGCCA
     2401 GTCCTACATC TTCGGTTGTG GGAAGAACCA CCCAGTCTTT GGGGGTGATG
     2451 TCCTCTGCTC TCCCTGAGTC AACCTCTAGA GGAATGACAC ACTCCGAGCA
     2501 AAGAACCAGC CCATCGCTGA GTCCCCAGGT CAATGGAACT CCCTCTAGGA
     2551 ACTACCCTGC TACAAGCATG GTTTCAGGAT TGAGTTCCCC AAGGACCAGG
     2601 ACCAGTTCCA CAGAAGGAAA TTTTACCAAA GAAGCATCTA CATACACACT
     2651 CACTGTAGAG ACCACAAGTG GCCCAGTCAC TGAGAAGTAC ACAGTCCCCA
     2701 CTGAGACCTC AACAACTGAA GGTGACAGCA CAGAGACCCC CTGGGACACA
     2751 AGATATATTC CTGTAAAAAT CACATCTCCA ATGAAAACAT TTGCAGATTC
     2801 AACTGCATCC AAGGAAAATG CCCCAGTGTC TATGACTCCA GCTGAGACCA
     2851 CAGTTACTGA CTCACATACT CCAGGAAGGA CAAACCCATC ATTTGGGACA
     2901 CTTTATTCTT CCTTCCTTGA CCTATCACCT AAAGGGACCC CAAATTCCAG
     2951 AGGTGAAACA AGCCTGGAAC TGATTCTATC AACCACTGGA TATCCCTTCT
     3001 CCTCTCCTGA ACCTGGCTCT GCAGGACACA GCAGAATAAG TACCAGTGCG
     3051 CCTTTGTCAT CATCTGCTTC AGTTCTCGAT AATAAAATAT CAGAGACCAG
     3101 CATATTCTCA GGCCAGAGTC TCACCTCCCC TCTGTCTCCT GGGGTGCCCG
     3151 AGGCCAGAGC CAGCACAATG CCCAACTCAG CTATCCCTTT TTCCATGACA
     3201 CTAAGCAATG CAGAAACAAG TGCCGAAAGG GTCAGAAGCA CAATTTCCTC
     3251 TCTGGGGACT CCATCAATAT CCACAAAGCA GACAGCAGAG ACTATCCTTA
     3301 CCTTCCATGC CTTCGCTGAG ACCATGGATA TACCCAGCAC CCACATAGCC
     3351 AAGACTTTGG CTTCAGAATG GTTGGGAAGT CCAGGTACCC TTGGTGGCAC
     3401 CAGCACTTCA GCGCTGACAA CCACATCTCC ATCTACCACT TTAGTCTCAG
     3451 AGGAGACCAA CACCCATCAC TCCACGAGTG GAAAGGAAAC AGAAGGAACT
     3501 TTGAATACAT CTATGACTCC ACTTGAGACC TCTGCTCCTG GAGAAGAGTC
     3551 CGAAATGACT GCCACCTTGG TCCCCACTCT AGGTTTTACA ACTCTTGACA
     3601 GCAAGATCAG AAGTCCATCT CAGGTCTCTT CATCCCACCC AACAAGAGAG
     3651 CTCAGAACCA CAGGCAGCAC CTCTGGGAGG CAGAGTTCCA GCACAGCTGC
     3701 CCACGGGAGC TCTGACATCC TGAGGGCAAC CACTTCCAGC ACCTCAAAAG
     3751 CATCATCATG GACCAGTGAA AGCACAGCTC AGCAATTTAG TGAACCCCAG
     3801 CACACACAGT GGGTGGAGAC AAGTCCTAGC ATGAAAACAG AGAGACCCCC
     3851 AGCATCAACC AGTGTGGCAG CCCCTATCAC CACTTCTGTT CCCTCAGTGG
     3901 TCTCTGGCTT CACCACCCTG AAGACCAGCT CCACAAAAGG GATTTGGCTT
     3951 GAAGAAACAT CTGCAGACAC ACTCATCGGA GAATCCACAG CTGGCCCAAC
     4001 CACCCATCAG TTTGCTGTTC CCACTGGGAT TTCAATGACA GGAGGCAGCA
     4051 GCACCAGGGG AAGCCAGGGC ACAACCCACC TACTCACCAG AGCCACAGCA
     4101 TCATCTGAGA CATCCGCAGA TTTGACTCTG GCCACGAACG GTGTCCCAGT
     4151 CTCCGTGTCT CCAGCAGTGA GCAAGACGGC TGCTGGCTCA AGTCCTCCAG
     4201 GAGGGACAAA GCCATCATAT ACAATGGTTT CTTCTGTCAT CCCTGAGACA
     4251 TCATCTCTAC AGTCCTCAGC TTTCAGGGAA GGAACCAGCC TGGGACTGAC
     4301 TCCATTAAAC ACTAGACATC CCTTCTCTTC CCCTGAACCA GACTCTGCAG
     4351 GACACACCAA GATAAGCACC AGCATTCCTC TGTTGTCATC TGCTTCAGTT
     4401 CTTGAGGATA AAGTGTCAGC GACCAGCACA TTCTCACACC ACAAAGCCAC
     4451 CTCATCTATT ACCACAGGGA CTCCTGAAAT CTCAACAAAG ACAAAGCCCA
     4501 GCTCAGCCGT TCTTTCCTCC ATGACCCTAA GCAATGCAGC AACAAGTCCT
     4551 GAAAGAGTCA GAAATGCAAC TTCCCCTCTG ACTCATCCAT CTCCATCAGG
     4601 GGAAGAGACA GCAGGGAGTG TCCTCACTCT CAGCACCTCT GCTGAGACTA
     4651 CAGACTCACC TAACATCCAC CCAACTGGGA CACTGACTTC AGAATCGTCA
     4701 GAGAGTCCTA GCACTCTCAG CCTCCCAAGT GTCTCTGGAG TCAAAACCAC
     4751 ATTTTCTTCA TCTACTCCTT CCACTCATCT ATTTACTAGT GGAGAAGAAA
     4801 CAGAGGAAAC TTCGAATCCA TCTGTGTCTC AACCTGAGAC TTCTGTTTCC
     4851 AGAGTAAGGA CCACCTTGGC CAGCACCTCT GTCCCTACCC CAGTATTCCC
     4901 CACCATGGAC ACCTGGCCTA CACGTTCAGC TCAGTTCTCT TCATCCCACC
     4951 TAGTGAGTGA GCTCAGAGCT ACGAGCAGTA CCTCAGTTAC AAACTCAACT
     5001 GGTTCAGCTC TTCCTAAAAT ATCTCACCTC ACTGGGACGG CAACAATGTC
     5051 ACAGACCAAT AGAGACACGT TTAATGACTC TGCTGCACCC CAAAGCACAA
     5101 CTTGGCCAGA GACTAGTCCC AGATTCAAGA CAGGGTTACC TTCAGCAACA
     5151 ACCACTGTTT CAACCTCTGC CACTTCTCTC TCTGCTACTG TAATGGTCTC
     5201 TAAATTCACT TCTCCAGCAA CTAGTTCCAT GGAAGCAACT TCTATCAGGG
     5251 AACCATCAAC AACCATCCTC ACAACAGAGA CCACGAATGG CCCAGGCTCT
     5301 ATGGCTGTGG CTTCTACCAA CATCCCAATT GGAAAGGGCT ACATTACTGA
     5351 AGGAAGATTG GACACAAGCC ATCTGCCCAT TGGAACCACA GCTTCCTCTG
     5401 AGACATCTAT GGATTTTACC ATGGCCAAAG AAAGTGTCTC AATGTCAGTA
     5451 TCTCCATCTC AGTCCATGGA TGCTGCTGGC TCAAGCACTC CAGGAAGGAC
     5501 AAGCCAATTC GTTGACACAT TTTCTGATGA TGTCTATCAT TTAACATCCA
     5551 GAGAAATTAC AATACCTAGA GATGGAACAA GCTCAGCTCT GACTCCACAA
     5601 ATGACTGCAA CTCACCCTCC ATCTCCTGAT CCTGGCTCTG CTAGAAGCAC
     5651 CTGGCTTGGC ATCTTGTCCT CATCTCCTTC TTCTCCTACT CCCAAAGTCA
     5701 CAATGAGCTC CACATTTTCA ACTCAGAGAG TCACCACAAG CATGATAATG
     5751 GACACAGTTG AAACTAGTCG GTGGAACATG CCCAACTTAC CTTCCACGAC
     5801 TTCCTTGACA CCAAGTAATA TTCCAACAAG TGGTGCCATA GGAAAAAGCA
     5851 CCCTGGTTCC CTTGGACACT CCATCTCCAG CCACATCATT GGAGGCATCA
     5901 GAAGGGGGAC TTCCAACCCT CAGCACCTAC CCTGAATCAA CAAACACACC
     5951 CAGCATCCAC CTCGGAGCAC ACGCTAGTTC AGAAAGTCCA AGCACCATCA
     6001 AACTTACCAT GGCTTCAGTA GTAAAACCTG GCTCTTACAC ACCTCTCACC
     6051 TTCCCCTCAA TAGAGACCCA CATTCATGTA TCAACAGCCA GAATGGCTTA
     6101 CTCTTCTGGG TCTTCACCTG AGATGACAGC TCCTGGAGAG ACTAACACTG
     6151 GTAGTACCTG GGACCCCACC ACCTACATCA CCACTACGGA TCCTAAGGAT
     6201 ACAAGTTCAG CTCAGGTCTC TACACCCCAC TCAGTGAGGA CACTCAGAAC
     6251 CACAGAAAAC CATCCAAAGA CAGAGTCCGC CACCCCAGCT GCTTACTCTG
     6301 GAAGTCCTAA AATCTCAAGT TCACCCAATC TCACCAGTCC GGCCACAAAA
     6351 GCATGGACCA TCACAGACAC AACTGAACAC TCCACTCAAT TACATTACAC
     6401 AAAATTGGCA GAAAAATCAT CTGGATTTGA GACACAGTCA GCTCCAGGAC
     6451 CTGTCTCTGT AGTAATCCCT ACCTCCCCTA CCATTGGAAG CAGCACATTG
     6501 GAACTAACTT CTGATGTCCC AGGGGAACCC CTGGTCCTTG CTCCCAGTGA
     6551 GCAGACCACA ATCACTCTCC CCATGGCAAC ATGGCTGAGT ACCAGTTTGA
     6601 CAGAGGAAAT GGCTTCAACA GACCTTGATA TTTCAAGTCC AAGTTCACCC
     6651 ATGAGTACAT TTGCTATTTT TCCACCTATG TCCACACCTT CTCATGAACT
     6701 TTCAAAGTCA GAGGCAGATA CCAGTGCCAT TAGAAATACA GATTCAACAA
     6751 CGTTGGATCA GCACCTAGGA ATCAGGAGTT TGGGCAGAAC TGGGGACTTA
     6801 ACAACTGTTC CTATCACCCC ACTGACAACC ACGTGGACCA GTGTGATTGA
     6851 ACACTCAACA CAAGCACAGG ACACCCTTTC TGCAACGATG AGTCCTACTC
     6901 ACGTGACACA GTCACTCAAA GATCAAACAT CTATACCAGC CTCAGCATCC
     6951 CCTTCCCATC TTACTGAAGT CTACCCTGAG CTCGGGACAC AAGGGAGAAG
     7001 CTCCTCTGAG GCAACCACTT TTTGGAAACC ATCTACAGAC ACACTGTCCA
     7051 GAGAGATTGA GACTGGCCCA ACAAACATTC AATCCACTCC ACCCATGGAC
     7101 AACACAACAA CAGGGAGCAG TAGTAGTGGA GTCACCCTGG GCATAGCCCA
     7151 CCTTCCCATA GGAACATCCT CCCCAGCTGA GACATCCACA AACATGGCAC
     7201 TGGAAAGAAG AAGTTCTACA GCCACTGTCT CTATGGCTGG GACAATGGGA
     7251 CTCCTTGTTA CTAGTGCTCC AGGAAGAAGC ATCAGCCAGT CATTAGGAAG
     7301 AGTTTCCTCT GTCCTTTCTG AGTCAACTAC TGAAGGAGTC ACAGATTCTA
     7351 GTAAGGGAAG CAGCCCAAGG CTGAACACAC AGGGAAATAC AGCTCTCTCC
     7401 TCCTCTCTTG AACCCAGCTA TGCTGAAGGA AGCCAGATGA GCACAAGCAT
     7451 CCCTCTAACC TCATCTCCTA CAACTCCTGA TGTGGAATTC ATAGGGGGCA
     7501 GCACATTTTG GACCAAGGAG GTCACCACAG TTATGACCTC AGACATCTCC
     7551 AAGTCTTCAG CAAGGACAGA GTCCAGCTCA GCTACCCTTA TGTCCACAGC
     7601 TTTGGGAAGC ACTGAAAATA CAGGAAAAGA AAAACTCAGA ACTGCCTCTA
     7651 TGGATCTTCC ATCTCCAACT CCATCAATGG AGGTGACACC ATGGATTTCT
     7701 CTCACTCTCA GTAATGCCCC CAATACCACA GATTCACTTG ACCTCAGCCA
     7751 TGGGGTGCAC ACCAGCTCTG CAGGGACTTT GGCCACTGAC AGGTCATTGA
     7801 ATACTGGTGT CACTAGAGCC TCCAGATTGG AAAACGGCTC TGATACCTCT
     7851 TCTAAGTCCC TGTCTATGGG AAACAGCACT CACACTTCCA TGACTTACAC
     7901 AGAGAAGAGT GAAGTGTCTT CTTCAATCCA TCCCCGACCT GAGACCTCAG
     7951 CTCCTGGAGC AGAGACCACT TTGACTTCCA CTCCTGGAAA CAGGGCCATA
     8001 AGCTTAACAT TGCCTTTTTC ATCCATTCCA GTGGAAGAAG TCATTTCTAC
     8051 AGGCATAACC TCAGGACCAG ACATCAACTC AGCACCCATG ACACATTCTC
     8101 CCATCACCCC ACCAACAATT GTATGGACCA GTACAGGCAC AATTGAACAG
     8151 TCCACTCAAC CACTACATGC AGTTTCTTCA GAAAAAGTTT CTGTGCAGAC
     8201 ACAGTCAACT CCATATGTCA ACTCTGTGGC AGTGTCTGCT TCCCCTACCC
     8251 ATGAGAATTC AGTCTCTTCT GGAAGCAGCA CATCCTCTCC ATATTCCTCA
     8301 GCCTCACTTG AATCCTTGGA TTCCACAATC AGTAGGAGGA ATGCAATCAC
     8351 TTCCTGGCTA TGGGACCTCA CTACATCTCT CCCCACTACA ACTTGGCCAA
     8401 GTACTAGTTT ATCTGAGGCA CTGTCCTCAG GCCATTCTGG GGTTTCAAAC
     8451 CCAAGTTCAA CTACGACTGA ATTTCCACTC TTTTCAGCTG CATCCACATC
     8501 TGCTGCTAAG CAAAGAAATC CAGAAACAGA GACCCATGGT CCCCAGAATA
     8551 CAGCCGCGAG TACTTTGAAC ACTGATGCAT CCTCGGTCAC AGGTCTTTCT
     8601 GAGACTCCTG TGGGGGCAAG TATCAGCTCT GAAGTCCCTC TTCCAATGGC
     8651 CATAACTTCT AGATCAGATG TTTCTGGCCT TACATCTGAG AGTACTGCTA
     8701 ACCCGAGTTT AGGCACAGCC TCTTCAGCAG GGACCAAATT AACTAGGACA
     8751 ATATCCCTGC CCACTTCAGA GTCTTTGGTT TCCTTTAGAA TGAACAAGGA
     8801 TCCATGGACA GTGTCAATCC CTTTGGGGTC CCATCCAACT ACTAATACAG
     8851 AAACAAGCAT CCCAGTAAAC AGCGCAGGTC CACCTGGCTT GTCCACAGTA
     8901 GCATCAGATG TAATTGACAC ACCTTCAGAT GGGGCTGAGA GTATTCCCAC
     8951 TGTCTCCTTT TCCCCCTCCC CTGATACTGA AGTGACAACT ATCTCACATT
     9001 TCCCAGAAAA GACAACTCAT TCATTTAGAA CCATTTCATC TCTCACTCAT
     9051 GAGTTGACTT CAAGAGTGAC ACCTATTCCT GGGGATTGGA TGAGTTCAGC
     9101 TATGTCTACA AAGCCCACAG GAGCCAGTCC CTCCATTACA CTGGGAGAGA
     9151 GAAGGACAAT CACCTCTGCT GCTCCAACCA CTTCCCCCAT AGTTCTCACT
     9201 GCTAGTTTCA CAGAGACCAG CACAGTTTCA CTGGATAATG AAACTACAGT
     9251 AAAAACCTCA GATATCCTTG ACGCACGGAA AACAAATGAG CTCCCCTCAG
     9301 ATAGCAGTTC TTCTTCTGAT CTGATCAACA CCTCCATAGC TTCTTCAACT
     9351 ATGGATGTCA CTAAAACAGC CTCCATCAGT CCCACTAGCA TCTCAGGAAT
     9401 GACAGCAAGT TCCTCCCCAT CTCTCTTCTC TTCAGATAGA CCCCAGGTTC
     9451 CCACATCTAC AACAGAGACA AATACAGCCA CCTCTCCATC TGTTTCCAGT
     9501 AACACCTATT CTCTTGATGG GGGCTCCAAT GTGGGTGGCA CTCCATCCAC
     9551 TTTACCACCC TTTACAATCA CCCACCCTGT CGAGACAAGC TCGGCCCTAT
     9601 TAGCCTGGTC TAGACCAGTA AGAACTTTCA GCACCATGGT CAGCACTGAC
     9651 ACTGCCTCCG GAGAAAATCC TACCTCTAGC AATTCTGTGG TGACTTCTGT
     9701 TCCAGCACCA GGTACATGGA CCAGTGTAGG CAGTACTACT GACTTACCTG
     9751 CCATGGGCTT TCTCAAGACA AGTCCTGCAG GAGAGGCACA CTCACTTCTA
     9801 GCATCAACTA TTGAACCAGC CACTGCCTTC ACTCCCCATC TCTCAGCAGC
     9851 AGTGGTCACT GGATCCAGTG CTACATCAGA AGCCAGTCTT CTCACTACGA
     9901 GTGAAAGCAA AGCCATTCAT TCTTCACCAC AGACCCCAAC TACACCCACC
     9951 TCTGGAGCAA ACTGGGAAAC TTCAGCTACT CCTGAGAGCC TTTTGGTAGT
    10001 CACTGAGACT TCAGACACAA CACTTACCTC AAAGATTTTG GTCACAGATA
    10051 CCATCTTGTT TTCAACTGTG TCCACGCCAC CTTCTAAATT TCCAAGTACG
    10101 GGGACTCTGT CTGGAGCTTC CTTCCCTACT TTACTCCCGG ACACTCCAGC
    10151 CATCCCTCTC ACTGCCACTG AGCCAACAAG TTCATTAGCT ACATCCTTTG
    10201 ATTCCACCCC ACTGGTGACT ATAGCTTCGG ATAGTCTTGG CACAGTCCCA
    10251 GAGACTACCC TGACCATGTC AGAGACCTCA AATGGTGATG CACTGGTTCT
    10301 TAAGACAGTA AGTAACCCAG ATAGGAGCAT CCCTGGAATC ACTATCCAAG
    10351 GAGTAACAGA AAGTCCACTC CATCCTTCTT CCACTTCCCC CTCTAAGATT
    10401 GTTGCTCCAC GGAATACAAC CTATGAAGGT TCGATCACAG TGGCACTTTC
    10451 TACTTTGCCT GCGGGAACTA CTGGTTCCCT TGTATTCAGT CAGAGTTCTG
    10501 AAAACTCAGA GACAACGGCT TTGGTAGACT CATCAGCTGG GCTTGAGAGG
    10551 GCATCTGTGA TGCCACTAAC CACAGGAAGC CAGGGTATGG CTAGCTCTGG
    10601 AGGAATCAGA AGTGGGTCCA CTCACTCAAC TGGAACCAAA ACATTTTCTT
    10651 CTCTCCCTCT GACCATGAAC CCAGGTGAGG TTACAGCCAT GTCTGAAATC
    10701 ACCACGAACA GACTGACAGC TACTCAATCA ACAGCACCCA AAGGGATACC
    10751 TGTGAAGCCC ACCAGTGCTG AGTCAGGCCT CCTAACACCT GTCTCTGCCT
    10801 CCTCAAGCCC ATCAAAGGCC TTTGCCTCAC TGACTACAGC TCCCCCAACT
    10851 TGGGGGATCC CACAGTCTAC CTTGACATTT GAGTTTTCTG AGGTCCCAAG
    10901 TTTGGATACT AAGTCCGCTT CTTTACCAAC TCCTGGACAG TCCCTGAACA
    10951 CCATTCCAGA CTCAGATGCA AGCACAGCAT CTTCCTCACT GTCCAAGTCT
    11001 CCAGAAAAAA ACCCAAGGGC AAGGATGATG ACTTCCACAA AGGCCATAAG
    11051 TGCAAGCTCA TTTCAATCAA CAGGTTTTAC TGAAACCCCT GAGGGATCTG
    11101 CCTCCCCTTC TATGGCAGGG CATGAACCCA GAGTCCCCAC TTCAGGAACA
    11151 GGGGACCCTA GATATGCCTC AGAGAGCATG TCTTATCCAG ACCCAAGCAA
    11201 GGCATCATCA GCTATGACAT CGACCTCTCT TGCATCAAAA CTCACAACTC
    11251 TCTTCAGCAC AGGTCAAGCA GCAAGGTCTG GTTCTAGTTC CTCTCCCATA
    11301 AGCCTATCCA CTGAGAAAGA AACAAGCTTC CTTTCCCCCA CTGCATCCAC
    11351 CTCCAGAPAG ACTTCACTAT TTCTTGGGCC TTCCATGGCA AGGCAGCCCA
    11401 ACATATTGGT GCATCTTCAG ACTTCAGCTC TGACACTTTC TCCAACATCC
    11451 ACTCTAAATA TGTCCCAGGA GGAGCCTCCT GAGTTAACCT CAAGCCAGAC
    11501 CATTGCAGAA GAAGAGGGAA CAACAGCTGA AACACAGACG TTAACCTTCA
    11551 CACCATCTGA GACCCCAACA TCCTTGTTAC CTGTCTCTTC TCCCACAGAA
    11601 CCCACAGCCA GAAGAAAGAG TTCTCCAGAA ACATGGGCAA GCTCTATTTC
    11651 AGTTCCTGCC AAGACCTCCT TGGTTGAAAG TAAGAATGCC CTGCTCCTTC
    11701 CCCAAGTGTG CTGGGGATGA ATCTGGAAAT AAACTACATC TTTTTTATTT
    11751 TTTAAACTTT TATATTTGAA AATATAAATA TTTTAGGTTC AGGGAACATG
    11801 TGCAGGTTTG TTATATAGGT AAATTGCATG TCATGGGGGC TTGGGGTACA
    11851 GATTACATCA TCAGCCAGGT AATAAGCCTA GTACCTGATC AGTAGATTTT
    11901 TTTTAATCCT CTCCCTCCTC CCAGCCTCCA CCCTCAATTC ACATGTCTCC
    11951 ATGTGTACTC AAGGTTTAAT TCCCACTTAT GAGTGAGAAC ATGCGGTATT
    12001 TGTAAACTAC ATCTTTATTT TTGCTAACCT CGAACTGAAA TTTAGCATTT
    12051 GTTTTATTGA TGAATAGAGG TAACAAAACA AACCACATTA ATCCTAGCAG
    12101 TGCCTGTGCC TTTGCCAACA ACAGAAATTC CGGACACTTT CATATCCTAT
    12151 GACAATTGTT GCAAGCACTT TTAAAAATCA TGTACGACTT TATTCATAAT
    12201 TATAGTGGTT ATTAGGCTTT TCAATAGATC TTATTTAATG AGTTAGTAAA
    12251 ATAAGTGCCT GTATTATTGT ATTACATTTG TTTATTAAGA TCTTGATAAC
    12301 AACATTTCAA TATAATCATT TCCTTTGTTT TTTAAATTTT AGATTCAGGG
    12351 GTATATGTGC AGGTTTGTTA CGTGGATATA CTGCATAATG ATGAGGTTTG
    12401 GCTTCTAGTG AACCCATCAG CCAAATAGTG AATGTTGTGC CCAATAAGTA
    12451 GTTTTTCAAT CCTCACTTCA CTCCCAGCCT CCTCTATTTT GGAGTCCCAG
    12501 TGTCTATTAT TTCTATCTTT ATGTCCACAT GTACCCATTG GTTAGCTCCC
    12551 ACTTATAAGT GAGAATGTGC AGTATTTAAT TTTCTGTTTT TGAGTTATTT
    12601 TGCTTAGGTT GATGGCCTTC AGCTCCAGCC ACGTTGCTTT AAAGAACATG
    12651 ATTTCATTCT TTTTTATGGC TGCATAGTAC TCCGAGGTGT ATGTGTACCA
    12701 GATTTTCTTT ATCCACAATG ATTTCCTTTG TAATCTAATA TTTTATATTG
    12751 TTATTTTATG TTTTATTCTA TATTTTTATT TTAATTTATA AAGGAATTCA
    12801 TATGGTTCAC AAGCCTGTCA AAGGGACCTA TAATAAAAAG AGGTTAAGAA
    12851 TCCATGCTCT AAACAGAATA TTACTCCATT TTATTTCATT TATTTTTAAA
    12901 GAGACAGTCT CACTCTGTCA TCCAGGCTGG AGTACAGTGG AGTGATCATA
    12951 GCTCATTGCA ACCCTGAACT CTTGGGCACA AGCAATTCTC CTGCTTCATC
    13001 CTCCAGAGGA GCTGGGACTA CAGGTGCACA TCACCATGCC CAGCTAGTTT
    13051 TAAAAATTAT TTTGTAGAGA TGGTGTCTCA CTATCCTACC CAGGCTGGTC
    13101 TCAAACTCCT GGGCTCAGGC AATCCTCCCA CTTTGACCTC CCAAAGTGTT
    13151 GAGATTACAG GGGCAAGCCA CTGTGCCTGG CCACTTGTCA CATTTTAATT
    13201 TGTGATTACT TATAAAATGA ACCCCTTCCC ATCTGAGATC TGTCAGTCTT
    13251 TCTGGTGACG GTGCCTGGTG TCTGCTTTCT ACCATGTCCT GTTAGACTAG
    13301 TGTTTGATGG GAGGTCACCT GGGCAGCTGT CCAGCTCACT CACTGGGCTC
    13351 TAGAGCCTCT GAGTTGAAGC AAAATAGAAA GATCAGTCAA TGTAAAGAAA
    13401 GCTCAAAAAC TGACATTCTG AAGTAATGGA TAGCTAAACC TTCCTATTGC
    Exon 2
    13451 CCTTTTCTTT CAGCAACTGA TGGAACGCTA GTGACCACCA TAAAGATGTC
    13501 AAGCCAGGCA GCACAAGGAA ATTCCACGTG GCCTGCCCCA GCAGAGGAGA
    13551 CGGGGACCAG TCCAGCAGGT AAATATAGAC CTTGTTTCCA TTTCTGCTCT
    13601 GCTAATGCCA CCCAAGCCTT TCTTTTCTTT TCTTTTCTTT TCTTTTCTTT
    13651 TCTTTTCTTT TCTTTTCTTT CTCTCCCTTT CTTTCTTTCT TTCTTTCTTT
    13701 CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT CTTTCTTTCT TTCTTTCTTT
    13751 CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT CTTTCTTTCT TCTTTCTCTC
    13801 TCTCTCTTTC TTTCTTTCTC TTGTTCTTTT TAAATTTTTT ATTTTTTTAC
    13851 TTAATTTTTT TCACCCAAGC CTTAAGGCCA GTTTGGACCA GATAGTGAGA
    13901 CCCCACCTCT ATAAAAAAAA TTTTTAAAAA AAAAATAAGT TGGGCATCGT
    13951 GCAGGCCTGT AGTCCCTGCT ACTCGAGAGG CCAAGGTGGG AGGACAGCTT
    14001 GCTGCTGACT AAAAGTGCTG CTTATTGATT CTGGGAAGAA AAAATATACA
    14051 AGGCTTCAGT TTCATTATTT TATAAGTAAA TGCTAGCAAC TTTTCCTTTC
    14101 TTTCTCTCTT TCTCTCTTCC TCTCTTTCTC TCCTCTCCTT CTCTTCTCTC
    14151 TCTCTCTCTC TCTCTCTCTC TTTCTCTCTC CTCTCCTTCT CTTCTCTTCT
    14201 TTCTCTCTCT CTCTCTTTCA TTTATTTTTG AGACATGGTC TCATTCTGTC
    14251 ACCCAGGCTG GAGTACAGTG GTGTATATTT ACTGCAGTAC TCACTGTACT
    14301 CACTGCAGCC TCAAATTCCT GGGCTCAAGC TATCCTCTCA CCTCAGCCTC
    14351 CTGAGTAGCT GGGCAGCAGT CCAGCTCACT CACTGGGCTC TAGAGCCTCT
    14401 GTGCTATGCC CAGCTTATTG TTGTTGTTTT TTTAAATTTT TTTTTTTGTA
    14451 CAGATGGGGT CTCACTATGT GGCCCAAGGT GGTCTTAAAC TCCTGGCTCC
    14501 AAGAGATCCT CCCACCTCAG CCTCCCAAAG TGCAGGGATT ACAGGTGTGA
    14551 GCCACTGTGC CCAGCCTAGA CAGCATTTTT TTTTTTTGAA ACAGGGTCTC
    14601 CCTCTGTTGC CCAGGCTGGA GTGCAATGGC GTGTTCATGG TTCACTGCAG
    14651 CCTCAGCCTC CTCAGTCTCA AGCAATCCTC CAACTTCAGC CTCCCCCAAC
    14701 AGCTAGAACT GCAGGTGATC ATCACCAATT AGCCTGGTTA ATTGTGTGTG
    14751 TATTTCTTAA ATTTTTTGTA GAGATAGTTC TCACTATATT GCTTGGGCTG
    14801 GTCTCAAACT CCTGGACTCA AGTGATTCAC CTACCTCGGC CTCCCTAAGC
    14851 ACTGGGATTA CAGGCTTGAG CCACCACACC CGGCAAGGAC TAGGTTTTAA
    14901 AATAGGTTCC TAGGCTGGGT GTGGTGGCTT ACGCCCGTAA TCCCAGCACT
    14951 TTGGGAGGCT GAGGTGGGCG GATCACGAGG TCAGGAGTTT GAGACCAGCC
    15001 TGGCCAACAT AGTGAAACCC TGTCTCTACT AAAAATACAA AAAATTAGCT
    15051 GGGCATAGTG GCACACACCT GTAATCCCAG CTACTCGGGA GGCTGAGGAA
    15101 GGAGAATCAC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCAT
    15151 GCCATTGCTC TCCAGCCTGG GTGACAGAGC AAGACTCCAT CTAAAAAAAA
    15201 AAAAAAAAGT TCCTTTGACT TCTTGACACT CTTCTCTGAG GATATTGATC
    15251 ATTTTTCCCC AATAGATGTT ACTAATTGAA CACTTCTGTT GCTTCAACTT
    15301 ACTAATTTAC ATGATCAATA GCCAATTAAT TCAGCAGGAG AGAATGCTAC
    15351 AGAGTCGATT CTTTCTGTAC TTTCTTCTGC TCCAGAGTGA AGGATCTTTC
    15401 TAAATCAGAG ACCATCACTG TGTTCACAGG GAGGGCCTAG GTGAACCTGA
    15451 GATGGCAAAT GTTGCGTTTG TTCTACGGAA GAAGGGATTA TGGGTTGAAG
    15501 TCCTTGGCAG TGCCAAATTG CTTAGAAAAA TGTGAAATAT GGTCCCTAGG
    15551 AGTGCTCTTG GGATGTCACA TTTTTCTCAC TCCTTTGACA GGTAGATGTT
    15601 ATTTTCCTGA AGGCCAGGGA AAGGATTCAG AGGGAGGAAT GAATTTGAAA
    15651 GAAAATGAAG GTGACGAGAA AGAATGAGCT CATCTCCCTT ATCCTCTTTC
    15701 TTCTCAAATC CTTAAGTAGC TTTGCAGTGA ACTAAGATTT GGGGGAACCT
    15751 AGAGGAGGCT GAAAGTTGGA AGCTGAAATT GGCTTAGCAA GGGCAAGCTC
    15801 CAAAGACAAA AGTGGAAATA GTTTGGGGGT AGCCTTTTGC ATGGGTGAAA
    15851 TCCTGGTTCA TCACATCCTC CCTTATGCAA AGAGCCCTTT TATATGGGGC
    15901 ATGGGGAAAA ACTGAGCTAA AGGTGATAAT TTCTCCTGAG CAAGCCAGAT
    15951 GGTCAAAGCT CTAACTTCAC CATCTCCCTT GGAATGTTTA ATGTGTTCCC
    16001 TGGTGTCCAG AGGCTTAACG TGTGAGAATT AAAAGCTCAA CATTTTCTTT
    16051 CCCAGGGAAG GAGGAAATAG TTTTAATTGA AATCCCGGGA GGAAATGAAT
    16101 GATAGTGTCA AACCAAAAAA CTTCATCTTC TGTACCACTT GCATATACTC
    Exon 3
    16151 CACTGACTTA CTTTCTAATC ACAGGCACAT CCCCAGGAAG CCCAGAAATG
    16201 TCTACCACTC TCAAAATCAT GAGCTCCAAG GAACCCGGCA TCAGCCCAGA
    16251 GATCAGGTCC ACTGTGAGAA ATTCTCCTTG GAAGACTCCA GAAACAACTG
    16301 TTCCCATGGA GACCACAGTG GAACCAGTCA CCCTTCAGTC CACAGCCCTA
    16351 GGAAGTGGCA GCACCAGCAT CTCTCACCTG CCCACAGGAA CCACATCACC
    16401 AACCAAGTCA CCAACAGAAA ATATGTTGGC TACAGAAAGG GTCTCCCTCT
    16451 CCCCATCCCC ACCTGAGGCT TGGACCAACC TTTATTCTGG AACTCCAGGA
    16501 GGGACCAGGC AGTCACTGGC CACAATGTCC TCTGTCTCCC TAGAGTCACC
    16551 AACTGCTAGA AGCATCACAG GGACTGGTCA GCAAAGCAGT CCAGAACTGG
    16601 TTTTAAAGAC AACTGGAATG GAATTCTCTA TGTGGCATGG CTCTACTGGA
    16651 GGGACCACAG GGGACACACA TGTCTCTCTG AGCACATCTT CCAATATCCT
    16701 TGAAGACCCT GTAACCAGCC CAAACTCTGT GAGCTCATTG ACAGATAAAT
    16751 CCAAACATAA AACCGAGACA TGGGTCAGCA CCACAGCCAT TCCCTCCACT
    16801 GTCCTGAATA ATAAGATAAT GGCAGCTGAA CAACAGACAA GTCGATCTGT
    16851 GGATGAGGCT TATTCATCAA CTAGTTCTTG GTCAGATCAG ACATCTGGGA
    16901 GTGACATCAC CCTTGGTGCA TCTCCTGATG TCACAAACAC ATTATACATC
    16951 ACCTCCACAG CACAAACCAC CTCACTAGTA TCTCTGCCCT CTGGAGACCA
    17001 AGGCATTACA AGCCTCACCA ATCCCTCAGG AGGAAAAACA AGCTCTGCAT
    17051 CATCTGTCAC ATCTCCTTCA ATAGGGCTTG AGACTCTGAT GGCCAATGTA
    17101 AGTGCAGTGA CAAGTGACAT TGCCCCTACT GCTGGGCATC TATCTCAGAC
    17151 TTCATCTCCT GCGGAAGTGA GCATCCTGGA CATAACCACA GCTCCTACTC
    17201 CAGGTATCTC CACCACCATC ACCACCATGG GAACCAACTC AATCTCAACT
    17251 ACCACACCCA ACCCAGAAGT GGGTATGAGT ACCATGGACA GCACCCCGGC
    17301 CACAGAGAGG CACACAACTT CTACAGAACA CCCTTCCACC TGGTCTTCCA
    17351 CAGCTGCATC AGATTCCTGG ACTGTCACAG ACATGACTTC AAACTTGAAA
    17401 GTTGCAAGAT CTCCTGGAAC AATTTCCACA ATGCATACAA CTTCATTCTT
    17451 AGCCTCAAGC ACTGAATTAG ACTCCATGTC TACTCCCCAT GGCCGTATAA
    17501 CTGTCATTGG AACCAGCCTG GTCACTCCAT CCTCTGATGC TTCAGCTGTA
    17551 AAGACAGAGA CCAGTACAAG TGAAAGAACA TTGAGTCCTT CAGACACAAC
    17601 TGCATCTACT CCCATCTCAA CTTTTTCTCG TGTCCAGAGG ATGAGCATCT
    17651 CAGTTCCTGA CATTTTAAGT ACAAGTTGGA CTCCCAGTAG TACAGAAGCA
    17701 GAAGATGTGC CTGTTTCAAT GGTTTCTACA GATCATGCTA GTACAAAGAC
    17751 TGACCCAAAT ATGCCCCTGT CCACTTTTCT GTTTGATTCT CTGTCCACTC
    17801 TTGACTGGGA CACTGGGAGA TCTCTGTCAT CAGCCACAGC CACTACCTCA
    17851 GCTCCTCAGG GGGCCACAAC TCCCCAAGAA CTCACTTTGG AAACCATGAT
    17901 CAGCCCAGCT ACCTCACAGT TGCCCTTCTC TATAGGGCAC ATTACAAGTG
    17951 CAGTCATACC AGCTGCAATG GCAAGGAGCT CTGGAGTTAC TTTTTCAAGA
    18001 CCAGATCCCA CAAGCAAAAA GGCAGAGCAG ACTTCCACTC AGCTTCCCAC
    18051 CACCACTTCT GCACATCCAG AGCAGGTGCC CAGATCAGCA GCAACAACTC
    18101 TGGATGTGAT CCCACACACA GCAAAAACTC CAGATGCAAC TTTTCAGAGA
    18151 CAAGGGCAGA CAGCTCTTAC AACAGAGGCA AGAGCTACAT CTGACTCCTG
    18201 GAATGAGAAA GAAAAATCAA CCCCAAGTGC ACCTTGGATC ACTGAGATGA
    18251 TGAATTCTGT CTCAGAAGAT ACCATCAAGG AGGTTACCAG CTCCTCCAGT
    18301 GTGTTAAGGA CCCTGAATAC GCTGGACATA AACTTGGAAT CTGGGACGAC
    18351 TTCATCCCCA AGTTGGAAAA GCAGCCCATA TGAGAGAATT GCCCCTTCTG
    18401 AGTCTACCAC AGACAAAGAG GCAATTCACC CTTCTACAAA CACAGTAGAG
    18451 ACCACTGGCT GGGTCACAAG TTCCGAACAT GCTTCTCATT CCACTATCCC
    18501 AGCCCACTCA GCGTCATCCA AACTCACATC TCCAGTGGTT ACAACCTCCA
    18551 CCAGGGAACA AGCAATAGTT TCTATGTCAA CAACCACATG GCCAGAGTCT
    18601 ACAAGGGCTA GAACAGAGCC TAATTCCTTC TTGACTATTG AACTGAGGGA
    18651 CGTCAGCCCT TACATGGACA CCAGCTCAAC CACACAAACA AGTTTTATCT
    18701 CTTCCCCAGG TTCCACTGCG ATCACCAAGG GGCCTAGAAC AGAAATTACC
    18751 TCCTCTAAGA GAATATCCAG CTCATTCCTT GCCCAGTCTA TGAGGTCGTC
    18801 AGACAGCCCC TCAGAAGCCA TCTCCAGGCT GTCTAACTTT CCTGCCATGA
    18851 CAGAATCTGG AGGAATGATC CTTGCTATGC AAACAAGTCC ACCTGGCGCT
    18901 ACATCACTAA GTGCACCTAC TTTGGATACA TCAGCCACAG CCTCCTGGAC
    18951 AGGGACTCCA CTGGCTACGA CTCAGAGATT TACATACTCA GAGAAGACCA
    19001 CTCTCTTTAG CAAAGGTCCT GAGGATACAT CACAGCCAAG CCCTCCCTCT
    19051 GTGGAAGAAA CCAGCTCTTC CTCTTCCCTG GTACCTATCA ATGCTACAAC
    19101 CTCGCCTTCC AATATTTTGT TGACATCACA AGGGCACAGT CCCTCCTCTA
    19151 CTCCACCTGT GACCTCAGTT TTCTTGTCTG AGACCTCTGG CCTGGGGAAG
    19201 ACCACAGACA TGTCGAGGAT AAGCTTGGAA CCTGGCACAA GTTTACCTCC
    19251 CAATTTGAGC AGTACAGCAG GTGAGGCGTT ATCCACTTAT GAAGCCTCCA
    19301 GAGATACAAA GGCAATTCAT CATTCTGCAG ACACAGCAGT GACGAATATG
    19351 GAGGCAACCA GTTCTGAATA TTCTCCTATC CCAGGCCATA CAAAGCCATC
    19401 CAAAGCCACA TCTCCATTGG TTACCTCCCA CATCATGGGG GACATCACTT
    19451 CTTCCACATC AGTATTTGGC TCCTCCGAGA CCACAGAGAT TGAGACAGTG
    19501 TCCTCTGTGA ACCAGGGACT TCAGGAGAGA AGCACATCCC AGGTGGCCAG
    19551 CTCTGCTACA GAGACAAGCA CTGTCATTAC CCATGTGTCT AGTGGTGATG
    19601 CTACTACTCA TGTCACCAAG ACACAAGCCA CTTTCTCTAG CGGAACATCC
    19651 ATCTCAAGCC CTCATCAGTT TATAACTTCT ACCAACACAT TTACAGATGT
    19701 GAGCACCAAC CCCTCCACCT CTCTGATAAT GACAGAATCT TCAGGAGTGA
    19751 CCATCACCAC CCAAACAGGT CCTACTGGAG CTGCAACACA GGGTCCATAT
    19801 CTCTTGGACA CATCAACCAT GCCTTACTTG ACAGAGACTC CATTAGCTGT
    19851 GACTCCAGAT TTTATGCAAT CAGAGAAGAC CACTCTCATA AGCAAAGGTC
    19901 CCAAGGATGT GTCCTGGACA AGCCCTCCCT CTGTGGCAGA AACCAGCTAT
    19951 CCCTCTTCCC TGACACCTTT CTTGGTCACA ACCATACCTC CTGCCACTTC
    20001 CACGTTACAA GGGCAACATA CATCCTCTCC TGTTTCTGCG ACTTCAGTTC
    20051 TTACCTCTGG ACTGGTGAAG ACCACAGATA TGTTGAACAC AAGCATGGAA
    20101 CCTGTGACCA ATTCACCTCA AAATTTGAAC AATCCATCAA ATGAGATACT
    20151 GGCCACTTTG GCAGCCACCA CAGATATAGA GACTATTCAT CCTTCCATAA
    20201 ACAAAGCAGT GACCAATATG GGGACTGCCA GTTCAGCACA TGTACTGCAT
    20251 TCCACTCTCC CAGTCAGCTC AGAACCATCT ACAGCCACAT CTCCAATGGT
    20301 TCCTGCCTCC AGCATGGGGG ACGCTCTTGC TTCTATATCA ATACCTGGTT
    20351 CTGAGACCAC AGACATTGAG GGAGAGCCAA CATCCTCCCT GACTGCTGGA
    20401 CGAAAAGAGA ACAGCACCCT CCAGGAGATG AACTCAACTA CAGAGTCAAA
    20451 CATCATCCTC TCCAATGTGT CTGTGGGGGC TATTACTGAA GCCACAAAAA
    20501 TGGAAGTCCC CTCTTTTGAT GCAACATTCA TACCAACTCC TGCTCAGTCA
    20551 ACAAAGTTCC CAGATATTTT CTCAGTAGCC AGCAGTAGAC TTTCAAACTC
    20601 TCCTCCCATG ACAATATCTA CCCACATGAC CACCACCCAG ACAGGGTCTT
    20651 CTGGAGCTAC ATCAAAGATT CCACTTGCCT TAGACACATC AACCTTGGAA
    20701 ACCTCAGCAG GGACTCCATC AGTGGTGACT GAGGGGTTTG CCCACTCAAA
    20751 AATAACCACT GCAATGAACA ATGATGTCAA GGACGTGTCA CAGACAAACC
    20801 CTCCCTTTCA GGATGAAGCC AGCTCTCCCT CTTCTCAAGC ACCTGTCCTT
    20851 GTCACAACCT TACCTTCTTC TGTTGCTTTC ACACCGCAAT GGCACAGTAC
    20901 CTCCTCTCCT GTTTCTATGT CCTCAGTTCT TACTTCTTCA CTGGTAAAGA
    20951 CCGCAGGCAA GGTGGATACA AGCTTAGAAA CAGTGACCAG TTCACCTCAA
    21051 AGATATAGAG ACAACGCATC CTTCCATAAA CACAGTAGTT ACCAATGTGG
    21101 GGACCACCGG TTCAGCATTT GAATCACATT CTACTGTCTC AGCTTACCCA
    21151 GAGCCATCTA AAGTCACATC TCCAAATGTT ACCACCTCCA CCATGGAAGA
    21201 CACCACAATT TCCAGATCAA TACCTAAATC CTCTAAGACT ACAAGAACTG
    21251 AGACTGAGAC AACTTCCTCC CTGACTCCTA AACTGAGGGA GACCAGCGTC
    21301 TCCCAGGAGA TCACCTCGTC CACAGAGACA AGCACTGTTC CTTACAAAGA
    21351 GCTCACTGGT GCCACTACCG AGGTATCCAG GACAGATGTC ACTTCCTCTA
    21401 GCAGTACATC CTTCCCTGGC CCTGATCAGT CCACAGTGTC ACTAGACATC
    21451 TCCACAGAAA CCAACACCAG GCTGTCTACC TCCCCAATAA TGACAGAATC
    21501 TGCAGAAATA ACCATCACCA CCCAAACAGG TCCTCATGGG GCTACATCAC
    21551 AGGATACTTT TACCATGGAC CCATCAAATA CAACCCCCCA GGCAGGGATC
    21601 CACTCAGCTA TGACTCATGG ATTTTCACAA TTGGATGTGA CCACTCTTAT
    21651 GAGCAGAATT CCACAGGATG TATCATGGAC AAGTCCTCCC TCTGTGGATA
    21701 AAACCAGCTC CCCCTCTTCC TTTCTGCCCT CACCTGCAAT GACCACACCT
    21751 TCCCTGATTT CTTCTACCTT ACCAGAGGAT AAGCTCTCCT CTCCTATGAC
    21801 TTCACTTCTC ACCTCTGGCC TAGTGAAGAT TACAGACATA TTACGTACAC
    21851 GCTTGGAACC TGTGACCAGC TCACTTCCAA ATTTCAGCAG CACCTCAGAT
    21901 AAGATACTGG CCACTTCTAA AGACAGTAAA GACACAAAGG AAATTTTTCC
    21951 TTCTATAAAC ACAGAAGAGA CCAATGTGAA AGCCAACAAC TCTGGACATG
    22001 AATCCCATTC CCCTGCACTG GCTGACTCAG AGACACCCAA AGCCACAACT
    22051 CAAATGGTTA TCACCACCAC TGTGGGAGAT CCAGCTCCTT CCACATCAAT
    22101 GCCAGTGCAT GGTTCCTCTG AGACTACAAA CATTAAGAGA GAGCCAACAT
    22151 ATTTCTTGAC TCCTAGACTG AGAGAGACCA GTACCTCTCA GGAGTCCAGC
    22201 TTTCCCACGG ACACAAGTTT TCTACTTTCC AAAGTCCCCA CTGGTACTAT
    22251 TACTGAGGTC TCCAGTACAG GGGTCATCTC TTCTAGCAAA ATTTCCACCC
    22301 CAGACCATGA TAAGTCCACA GTGCCACCTG ACACCTTCAC AGGAGAGATC
    22351 CCCAGGGTCT TCACCTCCTC TATTAAGACA AAATCTGCAG AAATGACGAT
    22401 CACCACCCAA GCAAGTCCTC CTGAGTCTGC ATCGCACAGT ACCCTTCCCT
    22451 TGGACACATC AACCACACTT TCCCAGGGAG GGACTCATTC AACTGTGACT
    22501 CAGGGATTCC CATACTCAGA GGTGACCACT CTCATGGGCA TGGGTCCTGG
    22551 GAATGTGTCA TGGATGACAA CTCCCCCTGT GGAAGAAACC AGCTCTGTGT
    22601 CTTCCCTGAT GTCTTCACCT GCCATGACAT CCCCTTCTCC TGTTTCCTCC
    22651 ACATCACCAC AGAGCATCCC CTCCTCTCCT CTTCCTGTGA CTGCACTTCC
    22701 TACTTCTGTT CTGGTGACAA CCACAGATGT GTTGGGCACA ACAAGCCCAG
    22751 AGTCTGTAAC CAGTTCACCT CCAAATTTGA GCAGCATCAC TCATGAGAGA
    22801 CCGGCCACTT ACAAAGACAC TGCACACACA GAAGCCGCCA TGCATCATTC
    22851 CACAAACACC GCAGTGACCA ATGTAGGGAC TTCCGGGTCT GGACATAAAT
    22901 CACAATCCTC TGTCCTAGCT GACTCAGAGA CATCGAAAGC CACACCTCTG
    22951 ATGAGTACCA CCTCCACCCT GGGGGACACA AGTGTTTCCA CATCAACTCC
    23001 TAATATCTCT CAGACTAACC AAATTCAAAC AGAGCCAACA GCATCCCTGA
    23051 GCCCTAGACT GAGGGAGAGC AGCACGTCTG AGAAGACCAG CTCAACAACA
    23101 GAGACAAATA CTGCCTTTTC TTATGTGCCC ACAGGTGCTA TTACTCAGGC
    23151 CTCCAGAACA GAAATCTCCT CTAGCAGAAC ATCCATCTCA GACCTTGATC
    23201 GGTCCACAAT AGCACCCGAC ATCTCCACAG GAATGATCAC CAGGCTCTTC
    23251 ACCTCCCCCA TCATGACAAA ATCTGCAGAA ATGACCGTCA CCACTCAAAC
    23301 AACTACTCCT GGGGCTACAT CACAGGGTAT CCTTCCCTGG GACACATCAA
    23351 CCACACTTTT CCAGGGAGGG ACTCATTCAA CCGTGTCTCA GGGATTCCCA
    23401 CACTCAGAGA TAACCACTCT TCGGAGCAGA ACCCCTGGAG ATGTGTCATG
    23451 GATGACAACT CCCCCTGTGG AAGAAACCAG CTCTGGGTTT TCCCTGATGT
    23501 CACCTTCCAT GACATCCCCT TCTCCTGTTT CCTCCACATC ACCAGAGAGC
    23551 ATCCCCTCCT CTCCTCTCCC TGTGACTGCA CTTCTTACTT CTGTTCTGGT
    23601 GACAACCACA AATGTATTGG GCACAACAAG CCCAGAGCCC GTAACGAGTT
    23651 CACCTCCAAA TTTAAGCAGC CCCACACAGG AGAGACTGAC CACTTACAAA
    23701 GACACTGCGC ACACAGAAGC CATGCATGCT TCCATGCATA CAAACACTGC
    23751 AGTGGCCAAC GTGGGGACCT CCATTTCTGG ACATGAATCA CAATCTTCTG
    23801 TCCCAGCTGA TTCAGACACA TCCAAAGCCA CATCTCCAAT GGGTACCACC
    23851 TTCGCCATGG GGGATACAAG TGTTTCTACA TCAACTCCTG CCTTCTTTGA
    23901 GACTAGAATT CAGACTGAAT CAACATCCTC TTTGATTCCT GGATTAAGGG
    23951 ACACCAGGAC GTCTGAGGAG ATCAACACTG TGACAGAGAC CAGCACTGTC
    24001 CTTTCAGAAG TGCCCACTAC TACTACTACT GAGGTCTCCA GGACAGAAGT
    24051 TATCACTTCC AGCAGAACAA CCATCTCAGG GCCTGATCAT TCCAAAATGT
    24101 CACCCTACAT CTCCACAGAA ACCATCACCA GGCTCTCCAC TTTTCCTTTT
    24151 GTAACAGGAT CCACAGAAAT GGCCATCACC AACCAAACAG GTCCTATAGG
    24201 GACTATCTCA CAGGCTACCC TTACCCTGGA CACATCAAGC ACAGCTTCCT
    24251 GGGAAGGGAC TCACTCACCT GTGACTCAGA GATTTCCACA CTCAGAGGAG
    24301 ACCACTACTA TGAGCAGAAG TACTAAGGGC GTGTCATGGC AAAGCCCTCC
    24351 CTCTGTGGAA GAAACCAGTT CTCCTTCTTC CCCAGTGCCT TTACCTGCAA
    24401 TAACCTCACA TTCATCTCTT TATTCCGCAG TATCAGGAAG TAGCCCCACT
    24451 TCTGCTCTCC CTGTGACTTC CCTTCTCACC TCTGGCAGGA GGAAGACCAT
    24501 AGACATGTTG GACACACACT CAGAACTTGT GACCAGCTCC TTACCAAGTG
    24551 CAAGTAGCTT CTCAGGTGAG ATACTCACTT CTGAAGCCTC CACAAATACA
    24601 GAGACAATTC ACTTTTCAGA GAACACAGCA GAAACCAATA TGGGGACCAC
    24651 CAATTCTATG CATAAACTAC ATTCCTCTGT CTCAATCCAC TCCCAGCCAT
    24701 CCGGACACAC ACCTCCAAAG GTTACTGGAT CTATGATGGA GGACGCTATT
    24751 GTTTCCACAT CAACACCTGG TTCTCCTGAG ACTAAAAATG TTGACAGAGA
    24801 CTCAACATCC CCTCTGACTC CTGAACTGAA AGAGGACAGC ACCGCCCTGG
    24851 TGATGAACTC AACTACAGAG TCAAACACTG TTTTCTCCAG TGTGTCCCTG
    24901 GATGCTGCTA CTGAGGTCTC CAGGGCAGAA GTCACCTACT ATGATCCTAC
    24951 ATTCATGCCA GCTTCTGCTC AGTCAACAAA GTCCCCAGAC ATTTCACCTG
    25001 AAGCCAGCAG CAGTCATTCT AACTCTCCTC CCTTGACAAT ATCTACACAC
    25051 AAGACCATCG CCACACAAAC AGGTCCTTCT GGGGTGACAT CTCTTGGCCA
    25101 ACTGACCCTG GACACATCAA CCATAGCCAC CTCAGCAGGA ACTCCATCAG
    25151 CCAGAACTCA GGATTTTGTA GATTCAGAAA CAACCAGTGT CATGAACAAT
    25201 GATCTCAATG ATGTGTTGAA GACAAGCCCT TTCTCTGCAG AAGAAGCCAA
    25251 CTCTCTCTCT TCTCAGGCAC CTCTCCTTGT GACAACCTCA CCTTCTCCTG
    25301 TAACTTCCAC ATTGCAAGAG CACAGTACCT CCTCTCTTGT TTCTGTGACC
    25351 TCAGTACCCA CCCCTACACT GGCGAAGATC ACAGACATGG ACACAAACTT
    25401 AGAACCTGTG ACTCGTTCAC CTCAAAATTT AAGGAACACC TTGGCCACTT
    25451 CAGAAGCCAC CACAGATACA CACACAATGC ATCCTTCTAT AAACACAGCA
    25501 GTGGCCAATG TGGGGACCAC CAGTTCACCA AATGAATTCT ATTTTACTGT
    25551 CTCACCTGAC TCAGACCCAT ATAAAGCCAC ATCCGCAGTA GTTATCACTT
    25601 CCACCTCGGG GGACTCAATA GTTTCCACAT CAATGCCTAG ATCCTCTGCG
    25651 ATGAAAAAGA TTGAGTCTGA GACAACTTTC TCCCTGATAT TTAGACTGAG
    25701 GGAGACTAGC ACCTCCCAGA AAATTGGCTC ATCCTCAGAC ACAAGCACGG
    25751 TCTTTGACAA AGCATTCACT GCTGCTACTA CTGAGGTCTC CAGAACAGAA
    25801 CTCACCTCCT CTAGCAGAAC ATCCATCCAA GGCACTGAAA AGCCCACAAT
    25851 GTCACCGGAC ACCTCCACAA GATCTGTCAC CATGCTTTCT ACTTTTGCTG
    25901 GCCTGACAAA ATCCGAAGAA AGGACCATTG CCACCCAAAC AGGTCCTCAT
    25951 AGGGCGACAT CACAGGGTAC CCTTACCTGG GACACATCAA TCACAACCTC
    26001 ACAGGCAGGG ACCCACTCAG CTATGACTCA TGGATTTTCA CAATTAGATT
    26051 TGTCCACTCT TACGAGTAGA GTTCCTGAGT ACATATCAGG GACAAGCCCA
    26101 CCCTCTGTGG AAAAAACCAG CTCTTCCTCT TCCCTTCTGT CTTTACCAGC
    26151 AATAACCTCA CCGTCCCCTG TACCTACTAC ATTACCAGAA AGTAGGCCGT
    26201 CTTCTCCTGT TCATCTGACT TCACTCCCCA CCTCTGGCCT AGTGAAGACC
    26251 ACAGATATGC TGGCATCTGT GGCCAGTTTA CCTCCAAACT TGGGCAGCAC
    26301 CTCACATAAG ATACCGACTA CTTCAGAAGA CATTAAAGAT ACAGAGAAAA
    26351 TGTATCCTTC CACAAACATA GCAGTAACCA ATGTGGGGAC CACCACTTCT
    26401 GAAAAGGAAT CTTATTCGTC TGTCCCAGCC TACTCAGAAC CACCCAAAGT
    26451 CACCTCTCCA ATGGTTACCT CTTTCAACAT AAGGGACACC ATTGTTTCCA
    26501 CATCCATGCC TGGCTCCTCT GAGATTACAA GGATTGAGAT GGAGTCAACA
    26551 TTCTCCCTGG CTCATGGGCT GAAGGGAACC AGCACCTCCC AGGACCCCAT
    26601 CGTATCCACA GAGAAAAGTG CTGTCCTTCA CAAGTTGACC ACTGGTGCTA
    26651 CTGAGACCTC TAGGACAGAA GTTGCCTCTT CTAGAAGAAC ATCCATTCCA
    26701 GGCCCTGATC ATTCCACAGA GTCACCAGAC ATCTCCACTG AAGTGATCCC
    26751 CAGCCTGCCT ATCTCCCTTG GCATTACAGA ATCTTCAAAT ATGACCATCA
    26801 TCACTCGAAC AGGTCCTCCT CTTGGCTCTA CATCACAGGG CACATTTACC
    26851 TTGGACACAC CAACTACATC CTCCAGGGCA GGAACACACT CGATGGCGAC
    26901 TCAGGAATTT CCACACTCAG AAATGACCAC TGTCATGAAC AAGGACCCTG
    26951 AGATTCTATC ATGGACAATC CCTCCTTCTA TAGAGAAAAC CAGCTTCTCC
    27001 TCTTCCCTGA TGCCTTCACC AGCCATGACT TCACCTCCTG TTTCCTCAAC
    27051 ATTACCAAAG ACCATTCACA CCACTCCTTC TCCTATGACC TCACTGCTCA
    27101 CCCCTAGCCT AGTGATGACC ACAGACACAT TGGGCACAAG CCCAGAACCT
    27151 ACAACCAGTT CACCTCCAAA TTTGAGCAGT ACCTCACATG AGATACTGAC
    27201 AACAGATGAA GACACCACAG CTATAGAAGC CATGCATCCT TCCACAAGCA
    27251 CAGCAGCGAC TAATGTGGAA ACCACCAGTT CTGGACATGG GTCACAATCC
    27301 TCTGTCCTAG CTGACTCAGA AAAAACCAAG GCCACAGCTC CAATGGATAC
    27351 CACCTCCACC ATGGGGCATA CAACTGTTTC CACATCAATG TCTGTTTCCT
    27401 CTGAGACTAC AAAAATTAAG AGAGAGTCAA CATATTCCTT GACTCCTGGA
    27451 CTGAGAGAGA CCAGCATTTC CCAAAATGCC AGCTTTTCCA CTGACACAAG
    27501 TATTGTTCTT TCAGAAGTCC CCACTGGTAC TACTGCTGAG GTCTCCAGGA
    27551 CAGAAGTCAC CTCCTCTGGT AGAACATCCA TCCCTGGCCC TTCTCAGTCC
    27601 ACAGTTTTGC CAGAAATATC CACAAGAACA ATGACAAGGC TCTTTGCCTC
    27651 GCCCACCATG ACAGAATCAG CAGAAATGAC CATCCCCACT CAAACAGGTC
    27701 CTTCTGGGTC TACCTCACAG GATACCCTTA CCTTGGACAC ATCCACCACA
    27751 AAGTCCCAGG CAAAGACTCA TTCAACTTTG ACTCAGAGAT TTCCACACTC
    27801 AGAGATGACC ACTCTCATGA GCAGAGGTCC TGGAGATATG TCATGGCAAA
    27851 GCTCTCCCTC TCTGGAAAAT CCCAGCTCTC TCCCTTCCCT GCTGTCTTTA
    27901 CCTGCCACAA CCTCACCTCC TCCCATTTCC TCCACATTAC CAGTGACTAT
    27951 CTCCTCCTCT CCTCTTCCTG TGACTTCACT TCTCACCTCT AGCCCGGTAA
    28001 CGACCACAGA CATGTTACAC ACAAGCCCAG AACTTGTAAC CAGTTCACCT
    28051 CCAAAGCTGA GCCACACTTC AGATGAGAGA CTGACCACTG GCAAGGACAC
    28101 CACAAATACA GAAGCTGTGC ATCCTTCCAC AAACACAGCA GCGTCCAATG
    28151 TGGAGATTCC CAGCTCTGGA CATGAATCCC CTTCCTCTGC CTTAGCTGAC
    28201 TCAGAGACAT CCAAAGCCAC ATCACCAATG TTTATTACCT CCACCCAGGA
    28251 GGATACAACT GTTGCCATAT CAACCCCTCA CTTCTTGGAG ACTAGCAGAA
    28301 TTCAGAAAGA GTCAATTTCC TCCCTGAGCC CTAAATTGAG GGAGACAGGC
    28351 AGTTCTGTGG AGACAAGCTC AGCCATAGAG ACAAGTGCTG TCCTTTCTGA
    28401 AGTGTCCGTT GGTGCTACTA CTGAGATCTC CAGGACAGAA GTCACCTCCT
    28451 CTAGCAGAAC ATCCATCTCT GGTTCTGCTG AGTCCACAAT GTTGCCAGAA
    28501 ATATCCACCA CAAGAAAAAT CATTAAGTTC CCTACTTCCC CCATCCTGGC
    28551 AGAATCATCA GAAATGACCA TCAAGACCCA AACAAGTCCT CCTGGGTCTA
    28601 CATCAGAGAG TACCTTTACA TTAGACACAT CAACCACTCC CTCCTTGGTA
    28651 ATAACCCATT CGACTATGAC TCAGAGATTG CCACACTCAG AGATAACCAC
    28701 TCTTGTGAGT AGAGGTGCTG GGGATGTGCC ACGGCCCAGC TCTCTCCCTG
    28751 TGGAAGAAAC AAGCCCTCCA TCTTCCCAGC TGTCTTTATC TGCCATGATC
    28801 TCACCTTCTC CTGTTTCTTC CACATTACCA GCAAGTAGCC ACTCCTCTTC
    28851 TGCTTCTGTG ACTTCACTTC TCACACCAGG CCAAGTGAAG ACTACTGAGG
    28901 TGTTGGACGC AAGTGCAGAA CCTGAAACCA GTTCACCTCC AAGTTTGAGC
    28951 AGCACCTCAG TTGAAATACT GGCCACCTCT GAAGTCACCA CAGATACGGA
    29001 GAAAATTCAT CCTTTCTCAA ACACGGCAGT AACCAAAGTT GGAACTTCCA
    29051 GTTCTGGACA TGAATCCCCT TCCTCTGTCC TACCTGACTC AGAGACAACC
    29101 AAAGCCACAT CGGCAATGGG TACCATCTCC ATTATGGGGG ATACAAGTGT
    29151 TTCTACATTA ACTCCTGCCT TATCTAACAC TAGGAAAATT CAGTCAGAGC
    29201 CAGCTTCCTC ACTGACCACC AGATTGAGGG AGACCAGCAC CTCTGAAGAG
    29251 ACCAGCTTAG CCACAGAAGC AAACACTGTT CTTTCTAAAG TGTCCACTGG
    29301 TGCTACTACT GAGGTCTCCA GGACAGAAGC CATCTCCTTT AGCAGAACAT
    29351 CCATGTCAGG CCCTGAGCAG TCCACAATGT CACAAGACAT CTCCATAGGA
    29401 ACCATCCCCA GGATTTCTGC CTCCTCTGTC CTGACAGAAT CTGCAAAAAT
    29451 GACCATCACA ACCCAAACAG GTCCTTCGGA GTCTACACTA GAAAGTACCC
    29501 TTAATTTGAA CACAGCAACC ACACCCTCTT GGGTGGAAAC CCACTCTATA
    29551 GTAATTCAGG GATTTCCACA CCCAGAGATG ACCACTTCCA TGGGCAGAGG
    29601 TCCTGGAGGT GTGTCATGGC CTAGCCCTCC CTTTGTGAAA GAAACCAGCC
    29651 CTCCATCCTC CCCGCTGTCT TTACCTGCCG TGACCTCACC TCATCCTGTT
    29701 TCCACCACAT TCCTAGCACA TATCCCCCCC TCTCCCCTTC CTGTGACTTC
    29751 ACTTCTCACC TCTGGCCCGG CGACAACCAC AGATATCTTG GGTACAAGCA
    29801 CAGAACCTGG AACCAGTTCA TCTTCAAGTT TGAGCACCAC CTCCCATGAG
    29851 AGACTGACCA CTTACAAAGA CACTGCACAT ACAGAAGCCG TGCATCCTTC
    29901 CACAAACACA GGAGGGACCA ATGTGGCAAC CACCAGCTCT GGATATAAAT
    29951 CACAGTCCTC TGTCCTAGCT GACTCATCTC CAATGTGTAC CACCTCCACC
    30001 ATGGGGGATA CAAGTGTTCT CACATCAACT CCTGCCTTCC TTGAGACTAG
    30051 GAGGATTCAG ACAGAGCTAG CTTCCTCCCT GACCCCTGGA TTGAGGGAGT
    30101 CCAGTGGCTC TGAAGGGACC AGCTCAGGCA CCAAGATGAG CACTGTCCTC
    30151 TCTAAAGTGC CCACTGGTGC TACTACTGAG ATCTCCAAGG AAGACGTCAC
    30201 CTCCATCCCA GGTCCCGCTC AATCCACAAT ATCACCAGAC ATCTCCACAA
    30251 GAACCGTCAG CTGGTTCTCT ACATCCCCTG TCATGACAGA ATCAGCAGAA
    30301 ATAACCATGA ACACCCATAC AAGTCCTTTA GGGGCCACAA CACAAGGCAC
    30351 CAGTACTTTG GCCACGTCAA GCACAACCTC TTTGACAATG ACACACTCAA
    30401 CTATATCTCA AGGATTTTCA CACTCACAGA TGAGCACTCT TATGAGGAGG
    30451 GGTCCTGAGG ATGTATCATG GATGAGCCCT CCCCTTCTGG AAAAAACTAG
    30501 ACCTTCCTTT TCTCTGATGT CTTCACCAGC CACAACTTCA CCTTCTCCTG
    30551 TTTCCTCCAC ATTACCAGAG AGCATCTCTT CCTCTCCTCT TCCTGTGACT
    30601 TCACTCCTCA CGTCTGGCTT GGCAAAAACT ACAGATATGT TGCACAAAAG
    30651 CTCAGAACCT GTAACCAACT CACCTGCAAA TTTGAGCAGC ACCTCAGTTG
    30701 AAATACTGGC CACCTCTGAA GTCACCACAG ATACAGAGAA AACTCATCCT
    30751 TCTTCAAACA GAACAGTGAC CGATGTGGGG ACCTCCAGTT CTGGACATGA
    30801 ATCCACTTCC TTTGTCCTAG CTGACTCACA GACATCCAAA GTCACATCTC
    30851 CAATGGTTAT TACCTCCACC ATGGAGGATA CGAGTGTCTC CACATCAACT
    30901 CCTGGCTTTT TTGAGACTAG CAGAATTCAG ACAGAACCAA CATCCTCCCT
    30951 GACCCTTGGA CTGAGAAAGA CCAGCAGCTC TGAGGGGACC AGCTTAGCCA
    31001 CAGAGATGAG CACTGTCCTT TCTGGAGTGC CCACTGGTGC CACTGCTGAA
    31051 GTCTCCAGGA CAGAAGTCAC CTCCTCTAGC AGAACATCCA TCTCAGGCTT
    31101 TGCTCAGCTC ACAGTGTCAC CAGAGACTTC CACAGAAACC ATCACCAGAC
    31151 TCCCTACCTC CAGCATAATG ACAGAATCAG CAGAAATGAT GATCAAGACA
    31201 CAAACAGATC CTCCTGGGTC TACACCAGAG AGTACTCATA CTGTGGACAT
    31251 ATCAACAACA CCCAACTGGG TAGAAACCCA CTCGACTGTG ACTCAGAGAT
    31301 TTTCACACTC AGAGATGACC ACTCTTGTGA GCAGAAGCCC TGGTGATATG
    31351 TTATGGCCTA GTCAATCCTC TGTGGAAGAA ACCAGCTCTG CCTCTTCCCT
    31401 GCTGTCTCTG CCTGCCACGA CCTCACCTTC TCCTGTTTCC TCTACATTAG
    31451 TAGAGGATTT CCCTTCCGCT TCTCTTCCTG TGACTTCTCT TCTCACCCCT
    31501 GGCCTGGTGA TAACCACAGA CAGGATGGGC ATAAGCAGAG AACCTGGAAC
    31551 CAGTTCCACT TCAAATTTGA GCAGCACCTC CCATGAGAGA CTGACCACTT
    31601 TGGAAGACAC TGTAGATACA GAAGACATGC AGCCTTCCAC ACACACAGCA
    31651 GTGACCAACG TGAGGACCTC CATTTCTGGA CATGAATCAC AATCTTCTGT
    31701 CCTATCTGAC TCAGAGACAC CCAAAGCCAC ATCTCCAATG GGTACCACCT
    31751 ACACCATGGG GGAAACGAGT GTTTCCATAT CCACTTCTGA CTTCTTTGAG
    31801 ACCAGCAGAA TTCAGATAGA ACCAACATCC TCCCTGACTT CTGGATTGAG
    31851 GGAGACCAGC AGCTCTGAGA GGATCAGCTC AGCCACAGAG GGAAGCACTG
    31901 TCCTTTCTGA AGTGCCCAGT GGTGCTACCA CTGAGGTCTC CAGGACAGAA
    31951 GTGATATCCT CTAGGGGAAC ATCCATGTCA GGGCCTGATC AGTTCACCAT
    32001 ATCACCAGAC ATCTCTACTG AAGCGATCAC CAGGCTTTCT ACTTCCCCCA
    32051 TTATGACAGA ATCAGCAGAA AGTGCCATCA CTATTGAGAC AGGTTCTCCT
    32101 GGGGCTACAT CAGAGGGTAC CCTCACCTTG GACACCTCAA CAACAACCTT
    32151 TTGGTCAGGG ACCCACTCAA CTGCATCTCC AGGATTTTCA CACTCAGAGA
    32201 TGACCACTCT TATGAGTAGA ACTCCTGGAG ATGTGCCATG GCCGAGCCTT
    32251 CCCTCTGTGG AAGAAGCCAG CTCTGTCTCT TCCTCACTGT CTTCACCTGC
    32301 CATGACCTCA ACTTCTTTTT TCTCCACATT ACCAGAGAGC ATCTCCTCCT
    32351 CTCCTCATCC TGTGACTGCA CTTCTCACCC TTGGCCCAGT GAAGACCACA
    32401 GACATGTTGC GCACAAGCTC AGAACCTGAA ACCAGTTCAC CTCCAAATTT
    32451 GAGCAGCACC TCAGCTGAAA TATTAGCCAC GTCTGAAGTC ACCAAAGATA
    32501 GAGAGAAAAT TCATCCCTCC TCAAACACAC CTGTAGTCAA TGTAGGGACT
    32551 GTGATTTATA AACATCTATC CCCTTCCTCT GTTTTGGCTG ACTTAGTGAC
    32601 AACAAAACCC ACATCTCCAA TGGCTACCAC CTCCACTCTG GGGAATACAA
    32651 GTGTTTCCAC ATCAACTCCT GCCTTCCCAG AAACTATGAT GACACAGCCA
    32701 ACTTCCTCCC TGACTTCTGG ATTAAGGGAG ATCAGTACCT CTCAAGAGAC
    32751 CAGCTCAGCA ACAGAGAGAA GTGCTTCTCT TTCTGGAATG CCCACTGGTG
    32801 CTACTACTAA GGTCTCCAGA ACAGAAGCCC TCTCCTTAGG CAGAACATCC
    32851 ACCCCAGGTC CTGCTCAATC CACAATATCA CCAGAAATCT CCACGGAAAC
    32901 CATCACTAGA ATTTCTACTC CCCTCACCAC GACAGGATCA GCAGAAATGA
    32951 CCATCACCCC CAAAACAGGT CATTCTGGGG CATCCTCACA AGGTACCTTT
    33001 ACCTTGGACA CATCAAGCAG AGCCTCCTGG CCAGGAACTC ACTCAGCTGC
    33051 ATCTCACAGA TCTCCACACT CAGGGATGAC CACTCCTATG AGCAGAGGTC
    33101 CTGAGGATGT GTCATGGCCA AGCCGCCCAT CAGTGGAAAA AACTAGCCCT
    33151 CCATCTTCCC TGGTGTCTTT ATCTGCAGTA ACCTCACCTT CGCCACTTTA
    33201 TTCCACACCA TCTGAGAGTA GCCACTCATC TCCTCTCCGG GTGACTTCTC
    33251 TTTTCACCCC TGTCATGATG AAGACCACAG ACATGTTGGA CACAAGCTTG
    33301 GAACCTGTGA CCACTTCACC TCCCAGTATG AATATCACCT CAGATGAGAG
    33351 TCTGGCCACT TCTAAAGCCA CCATGGAGAC AGAGGCAATT CAGCTTTCAG
    33401 AAAACACAGC TGTGACTCAG ATGGGCACCA TCAGCGCTAG ACAAGAATTC
    33451 TATTCCTCTT ATCCAGGCCT CCCAGAGCCA TCCAAAGTGA CATCTCCAGT
    33501 GGTCACCTCT TCCACCATAA AAGACATTGT TTCTACAACC ATACCTGCTT
    33551 CCTCTGAGAT AACAAGAATT GAGATGGAGT CAACATCCAC CCTGACCCCC
    33601 ACACCAAGGG AGACCAGCAC CTCCCAGGAG ATCCACTCAG CCACAAAGCC
    33651 AAGCACTGTT CCTTACAAGG CACTCACTAG TGCCACGATT GAGGACTCCA
    33701 TGACACAAGT CATGTCCTCT AGCAGAGGAC CTAGCCCTGA TCAGTCCACA
    33751 ATGTCACAAG ACATATCCAG TGAAGTGATC ACCAGGCTCT CTACCTCCCC
    33801 CATCAAGGCA GAATCTACAG AAATGACCAT TACCACCCAA ACAGGTTCTC
    33851 CTGGGGCTAC ATCAAGGGGT ACCCTTACCT TGGACACTTC AACAACTTTT
    33901 ATGTCAGGGA CCCACTCAAC TGCATCTCAA GGATTTTCAC ACTCACAGAT
    33951 GACCGCTCTT ATGAGTAGAA CTCCTGGAGA TGTGCCATGG CTAAGCCATC
    34001 CCTCTGTGGA AGAAGCCAGC TCTGCCTCTT TCTCACTGTC TTCACCTGTC
    34051 ATGACCTCAT CTTCTCCCGT TTCTTCCACA TTACCAGACA GCATCCACTC
    34101 TTCTTCGCTT CCTGTGACAT CACTTCTCAC CTCAGGGCTG GTGAAGACCA
    34151 CAGAGCTGTT GGGCACAAGC TCAGAACCTG AAACCAGTTC ACCCCCAAAT
    34201 TTGAGCAGCA CCTCAGCTGA AATACTGGCC ACCACTGAAG TCACTACAGA
    34251 TACAGAGAAA CTGGAGATGA CCAATGTGGT AACCTCAGGT TATACACATG
    34301 AATCTCCTTC CTCTGTCCTA GCTGACTCAG TGACAACAAA GGCCACATCT
    34351 TCAATGGGTA TCACCTACCC CACAGGAGAT ACAAATGTTC TCACATCAAC
    34401 CCCTGCCTTC TCTGACACCN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    34451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    34501 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNCGGAAA CCAAGTTTCT
    Exon 4
    34551 AACCAACCCC TCCTTTTTGA CCCCAGTAGG ATTCAAACAA AGTCAAAGCT
    34601 CTCACTGACT CCTGGGTTGA TGGAGACCAG CATCTCTGAA GAGACCAGCT
    34651 CTGCCACAGA AAAAAGCACT GTCCTTTCTA GTGTGCCCAC TGGTGCTACT
    34701 ACTGAGGTCT CCAGGACAGA AGCCATCTCT TCTAGCAGAA CATCCATCCC
    34751 AGGCCCTGCT CAATCCACAA TGTCATCAGA CACCTCCATG GAAACCATCA
    34801 CTAGAATTTC TACCCCCCTC ACAAGGAAAG AATCAACAGA CATGGCCATC
    34851 ACCCCCAAAA CAGGTCCTTC TGGGGCTACC TCGCAGGGTA CCTTTACCTT
    34901 GGACTCATCA AGCACAGCCT CCTGGCCAGG AACTCACTCA GCTACAACTC
    34951 AGAGATTTCC ACAGTCAGTG GTGACAACTC CTATGAGCAG AGGTCCTGAG
    35001 GATGTGTCAT GGCCAAGCCC GCTGTCTGTG GAAAAAAACA GCCCTCCATC
    35051 TTCCCTGGTA TCTTCATCTT CAGTAACCTC ACCTTCGCCA CTTTATTCCA
    35101 CACCATCTGG GAGTAGCCAC TCCTCTCCTG TCCCTGTCAC TTCTCTTTTC
    35151 ACCTCTATCA TGATGAAGGC CACAGACATG TTGGATGCAA GTTTGGAACC
    35201 TGAGACCACT TCAGCTCCCA ATATGAATAT CACCTCAGAT GAGAGTCTGG
    35251 CCACTTCTAA AGCCACCACG GAGACAGAGG CAATTCACGT TTTTGAAAAT
    35301 ACAGCAGCGT CCCATGTGGA AACCACCAGT GCTACAGAGG AACTCTATTC
    35351 CTCTTCCCCA GGCTTCTCAG AGCCAACAAA AGTGATATCT CCAGTGGTCA
    35401 CCTCTTCCTC TATAAGAGAC AACATGGTTT CCACAACAAT GCCTGGCTCC
    35451 TCTGGCATTA CAAGGATTGA GATAGAGTCA ATGTCATCTC TGACCCCTGG
    35501 ACTGAGGGAG ACCAGAACCT CCCAGGACAT CACCTCATCC ACAGAGACAA
    35551 GCACTGTCCT TTACAAGATG TCCTCTGGTG CCACTCCTGA GGTCTCCAGG
    35601 ACAGAAGTTA TGCCCTCTAG CAGAACATCC ATTCCTGGCC CTGCTCAGTC
    35651 CACAATGTCA CTAGACATCT CCGATGAAGT TGTCACCAGG CTGTCTACCT
    35701 CTCCCATCAT GACAGAATCT GCAGAAATAA CCATCACCAC CCAAACAGGT
    35751 TATTCTCTGG CTACATCCCA GGTTACCCTT CCCTTGGGCA CCTCAATGAC
    35801 CTTTTTGTCA GGGACCCACT CAACTATGTC TCAAGGACTT TCACACTCAG
    35851 AGATGACCAA TCTTATGAGC AGGGGTCCTG AAAGTCTGTC ATGGACGAGC
    35901 CCTCGCTTTG TGGAAACAAC TAGATCTTCC TCTTCTCTGA CATCATTACC
    35951 TCTCACGACC TCACTTTCTC CTGTGTCCTC CACATTACTA GACAGTAGCC
    36001 CCTCCTCTCC TCTTCCTGTG ACTTCACTTA TCCTCCCAGG CCTGGTGAAG
    36051 ACTACAGAAG TGTTGGATAC AAGCTCAGAG CCTAAAACCA GTTCATCTCC
    36101 AAATTTGAGC AGCACCTCAG TTGAAATACC GGCCACCTCT GAAATCATGA
    36151 CAGATACAGA GAAAATTCAT CCTTCCTCAA ACACAGCGGT GGCCAAAGTG
    36201 AGGACCTCCA GTTCTGTTCA TGAATCTCAT TCCTCTGTCC TAGCTGACTC
    36251 AGAAACAACC ATAACCATAC CTTCAATGGG TATCACCTCC GCTGTGGACG
    36301 ATACCACTGT TTTCACATCA AATCCTGCCT TCTCTGAGAC TAGGAGGATT
    36351 CCGACAGAGC CAACATTCTC ATTGACTCCT GGATTCAGGG AGACTAGCAC
    36401 CTCTGAAGAG ACCACCTCAA TCACAGAAAC AAGTGCAGTC CTTTATGGAG
    36451 TGCCCACTAG TGCTACTACT GAAGTCTCCA TGACAGAAAT CATGTCCTCT
    36501 AATAGAACAC ACATCCCTGA CTCTGATCAG TCCACGATGT CTCCAGACAT
    36551 CATCACTGAA GTGATCACCA GGCTCTCTTC CTCATCCATG ATGTCAGAAT
    36601 CAACACAAAT GACCATCACC ACCCAAAAAA GTTCTCCTGG GGCTACAGCA
    36651 CAGAGTACTC TTACCTTGGC CACAACAACA GCCCCCTTGG CAAGGACCCA
    36701 CTCAACTGTT CCTCCTAGAT TTTTACACTC AGAGATGACA ACTCTTATGA
    36751 GTAGGAGTCC TGAAAATCCA TCATGGAAGA GCTCTCCCTT TGTGGAAAAA
    36801 ACTAGCTCTT CATCTTCTCT GTTGTCCTTA CCTGTCACGA CCTCACCTTC
    36851 TGTTTCTTCC ACATTACCGC AGAGTATCCC TTCCTCCTCT TTTTCTGTGA
    36901 CTTCACTCCT CACCCCAGGC ATGGTGAAGA CTACAGACAC AAGCACAGAA
    36951 CCTGGAACCA GTTTATCTCC AAATCTGAGT GGCACCTCAG TTGAAATACT
    37001 GGCTGCCTCT GAAGTCACCA CAGATACAGA GAAAATTCAT CCTTCTTCAA
    37051 GCATGGCAGT GACCAATGTG GGAACCACCA GTTCTGGACA TGAACTATAT
    37101 TCCTCTGTTT CAATCCACTC GGAGCCATCC AAGGCTACAT ACCCAGTGGG
    37151 TACTCCCTCT TCCATGGCTG AAACCTCTAT TTCCACATCA ATGCCTGCTA
    37201 ATTTTGAGAC CACAGGATTT GAGGCTGAGC CATTTTCTCA TTTGACTTCT
    37251 GGATTTAGGA AGACAAACAT GTCCCTGGAC ACCAGCTCAG TCACACCAAC
    37301 AAATACACCT TCTTCTCCTG GGTCCACTCA CCTTTTACAG AGTTCCAAGA
    37351 CTGATTTCAC CTCTTCTGCA AAAACATCAT CCCCAGACTG GCCTCCAGCC
    37401 TCACAGTATA CTGAAATTCC AGTGGACATA ATCACCCCCT TTAATGCTTC
    37451 TCCATCTATT ACGGAGTCCA CTGGGATAAC CTCCTTCCCA GAATCCAGGT
    37501 TTACTATGTC TGTAACAGAA AGTACTCATC ATCTGAGTAC AGATTTGCTG
    37551 CCTTCAGCTG AGACTATTTC CACTGGCACA GTGATGCCTT CTCTATCAGA
    37601 GGCCATGACT TCATTTGCCA CCACTGGAGT TCCACGAGCC ATCTCAGGTT
    37651 CAGGTAGTCC ATTCTCTAGG ACAGAGTCAG GCCCTGGGGA TGCTACTCTG
    37701 TCCACCATTG CAGAGAGCCT GCCTTCATCC ACTCCTGTGC CATTCTCCTC
    37751 TTCAACCTTC ACTACCACTG ATTCTTCAAC CATCCCAGCC CTCCATGAGA
    37801 TAACTTCCTC TTCAGCTACC CCATATAGAG TGGACACCAG TCTTGGGACA
    37851 GAGAGCAGCA CTACTGAAGG ACGCTTGGTT ATGGTCAGTA CTTTGGACAC
    37901 TTCAAGCCAA CCAGGCAGGA CATCTTCAAC ACCCATTTTG GATACCAGAA
    37951 TGACAGAGAG CGTTGAGCTG GGAACAGTGA CAAGTGCTTA TCAAGTTCCT
    38001 TCACTCTCAA CACGGTTGAC AAGAGAATGC GCATGGCGAG AAGGGAGAAG
    38051 TGTAGTTGGA TGGATAAAAG GAAGAATGGA GAGAAGAGTG AATGGAAGGA
    38101 AGCAAAGATG AAGCGGAGGA AGGATAGATG CACAGAAGGA AGGATGAAAA
    38151 GAAAGAAAGA TGATGGAAGA CAGGATTGAA GGGGATATAG ATTGAAGGAA
    38201 AGAAAGGTAG AAGGATGAAA TGAAGTAAAG ATTGAAGAAA AGATGGATGG
    38251 AAAGAAGAAA GGAGGGTGCA CAAAAAATCT CACACTTCAC CACATATGAT
    38301 TCATCCATAT AAGAAAAAAC CACTTGTACC CTCAAAGCTA TTGAAATACA
    38351 AACTTTTAAA TTAAAATTTT PAAAAGCAAG AGAAAGGAAA GAAGGGAGGA
    38401 AAGACAAAAG GAAGAATGGG TGATAGAAGG AAAGAATAAA AGGAAGAAAA
    38451 AATGGAAGAA TAGATGATCA GATCTAGGGA TGAATGAAAG GAAGGATGGA
    38501 CAAATCTATA GGTAGGTGGA TGGATCTATG GACAGGTGTG GCCACTTATG
    38551 GCACATAGTC CCAGCTCCAG TTCATACTGA TGGACTTGAG GAGTGTTTGT
    38601 GGCCATTGAA GTGGATCCAT TTAGACAGTG CTCTTCTTCT GAATGAGATG
    Exon 5
    38651 AGTTACCCCA GTTTTTCTCC CCACCTTCAT CTTCAGGAAC TGATGGCATT
    38701 ATGGAACACA TCACAAAAAT ACCCAATGAA GCAGCACACA GAGGTACCAT
    38751 AAGACCAGTC AAAGGCCCTC AGACATCCAC TTCGCCTGCC AGTCCTAAAG
    38801 GTAGGTTTAA CTTTGCTTAC CTCCCAGTAA TGCCACTCGT GACCATATTT
    38851 CCTCCTCCAG AGAGACAAAA TGTTTGTATT CTTTAGAGAG AGAATTGTGT
    38901 GTGGTTGTCA TAGGTTTCCC TGTCTGAACT GAGTCTTTAT CTAATGGTTA
    38951 CCAGGCAGAT GTTACCACTG TCTCTTTCTC CTCATGGCAT GCTGAGTGAG
    39001 TTTTGTCCAA CATCAAATAT TCACAAATTT GTCCATATTA ACCAAATTTT
    39051 AAAAATGCTC ATTAAAAACT TACTATGAGC TGGGCGCAGT GGCTCATGCC
    39101 TGTAATCCCA ATACTTTGGG AGGCTGAGCT GGGTGGATCA CCAGAGGTCA
    39151 AAAATTCGAG ACCAGTCTGA CCAAAATGGT GAAACTCCAT CTCTACTGAA
    39201 AATATAAAAA TTAGCCGGGC ATGGTGGCAC ACACCGTAAT CACAGCTACT
    39251 CAGGAGGCTG AGGCAAGAGA GTCACTTGAA CCACAGGAGG TAGAGGCTGC
    39301 AGTGAGCTGA GCATTGTGCC AATGCACTCC AGCCTGGGTG GCAGAGCAAG
    39351 ACTCCAGCTC AGAAATAAAT AATATATTAT ATATATATAT ATATGTTTTA
    39401 TTTAGATGGA ATATACTATA TATATATGTA TATATATATG TATGTATATA
    39451 TATATATGTA TGTATATATA TATATATATA TATATATATA TATATAGAGA
    39501 GAGAGAGAGA GAGAGAGAGA GAGAGAGACA GAGTATGTCT GAGAATGCAT
    39551 CCCGATAGTT CTAGCAAGGT AGGAAAAGGA AGTATCATAA CAGCCTTGAA
    39601 GTAGCCTGTT GAAACAGACA GACTCTCTTG TAAGAGAACT CACAAAATCT
    39651 AGGATTATAT CTCCCATGAT GAAAAATTTG GAACTGTACA TTTTTGTTTA
    39701 ACTGTCACTT AAATNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    39751 NNNNNNNNNN NNNNNNNNNN NCCAGGAGGC ACTGTGCTTG GCGCCTTTTT
    39801 ACCAACACTT TGAGATGGCC ATTGTACTTA TCCCCACTTT ATAGACGGGA
    39851 AAATGGAGGT CCAGCAATAT TTTTTAACTT AAAGAGCCAC CCATCTCTTT
    39901 AGAGAAAGAG CCAGAATCCC AGGCAGGGGC TATCTTATTC CAGAGCCCAA
    39951 GCTCTCAAAC ACATGATACA CAATACTTAA TCTCTCTCAA GTCAGAGGAG
    40001 ATCCACTTAA GTATACATCC ATCCACATAT TCATTCATTC AATCATTCAA
    40051 CAAATATTAG TTGAGCACTT ACCGTATGCC AAACAGTCAA ACGTGAATAG
    40101 CTGTTACAAA TGAGACTGTG AAGGATGGTA CAACGCAGAT TCAGACAGTG
    40151 TGATAAGGAA ATATTGAGAA GCAAAGATGA GTTCTGGAGT GAATTTGTAA
    40201 AGGTGGATGT GGGCTTGGAT TTCAATAATG GCAGAACTTA AGGAATCTGA
    40251 TGAGAAGTGG GCACTTCAGG CAGAGAGAAG AGCTTGAACA AGGCTCAGAG
    40301 GCTGACAGTG CAGGAAACAC ATGGGAAGAG GGAATAGAGT AGCGGTCAAG
    40351 AATTCACAGA GGAGTTATAG GTGAAGATGC AACCAAGTTA CAGACCAAGG
    40401 TAAGATAGGG GAATACCAAT CACAATCTCT TTTCCCATTC CAGAAGCATC
    40451 CCAGACACAT CCTAGTAACC GAGAGACATT TCTCTCCCTT TCCTCCTGTG
    40501 GAGAATAAAT AAGCTATTGC AAGTCCAGTA AGTGTAATCA TTTTGTTCAA
    Exon 6
    40551 ATTGTGTGCC CATTCCCCAA TTTACAGGAC TACACACAGG AGGGACAAAA
    40601 AGAATGGAGA CCACAACCAC AGCTCTGAAG ACCACCACCA CAGCTCTGAA
    40651 GACCACTTCC AGAGCCACCT TGACCACCAG TGTCTATACT CCCACTTTGG
    40701 GAACACTGAC TCCCCTCAAT GCATCAATGC AAATGGCCAG CACAATCCCC
    40751 ACAGAAATGA TGATCACAAC CCCATATGTT TTCCCTGATG TTCCAGAAAC
    40801 GACATCCTCA TTGGCTACCA GCCTGGGAGC AGAAACCAGC ACAGCTCTTC
    40851 CCAGGACAAC CCCATCTGTT TTCAATAGAG AATCAGAGAC CACAGCCTCA
    40901 CTGGTCTCTC GTTCTGGGGC AGAGAGAAGT CCGGTTATTC AAACTCTAGA
    40951 TGTTTCTTCT AGTGAGCCAG ATACAACAGC TTCATGGGTT ATCCATCCTG
    41001 CAGAGACCAT CCCAACTGTT TCCAAGACAA CCCCCAATTT TTTCCACAGT
    41051 GAATTAGACA CTGTATCTTC CACAGCCACC AGTCATGGGG CAGACGTCAG
    41101 CTCAGCCATT CCAACAAATA TCTCACCTAG TGAACTAGAT GCACTGACCC
    41151 CACTGGTCAC TATTTCGGGG ACAGATACTA GTACAACATT CCCAACACTG
    41201 ACTAAGTCCC CACATGAAAC AGAGACAAGA ACCACATGGC TCACTCATCC
    41251 TGCAGAGACC AGCTCAACTA TTCCCAGAAC AATCCCCAAT TTTTCTCATC
    41301 ATGAATCAGA TGCCACACCT TCAATAGCCA CCAGTCCTGG GGCAGAAACC
    41351 AGTTCAGCTA TTCCAATTAT GACTGTCTCA CCTGGTGCAG AAGATCTGGT
    41401 GACCTCACAG GTCACTAGTT CTGGGACAGA CAGAAATATG ACTATTCCAA
    41451 CTTTGACTCT TTCTCCTGGT GAACCAAAGA CGATAGCCTC ATTAGTCACC
    41501 CATCCTGAAG CACAGACAAG TTCGGCCATT CCAACTTCAA CTATCTCGCC
    41551 TGCTGTATCA CGGTTGGTGA CCTCAATGGT CACCAGTTTG GCGGCAAAGA
    41601 CAAGTACAAC TAATCGAGCT CTGACAAACT CCCCTGGTGA ACCAGCTACA
    41651 ACAGTTTCAT TGGTCACGCA TCCTGCACAG ACCAGCCCAA CAGTTCCCTG
    41701 GACAACTTCC ATTTTTTTCC ATAGTAAATC AGACACCACA CCTTCAATGA
    41751 CCACCAGTCA TGGGGCAGAA TCCAGTTCAG CTGTTCCAAC TCCAACTGTT
    41801 TCAACTGAGG TACCAGGAGT AGTGACCCCT TTGGTCACCA GTTCTAGGGC
    41851 AGTGATCAGT ACAACTATTC CAATTCTGAC TCTTTCTCCT GGTGAACCAG
    41901 AGACCACACC TTCAATGGCC ACCAGTCATG GGGAAGAAGC CAGTTCTGCT
    41951 ATTCCAACTC CAACTGTTTC ACCTGGGGTA CCAGGAGTGG TGACCTCTCT
    42001 GGTCACTAGT TCTAGGGCAG TGACTAGTAC AACTATTCCA ATTCTGACTT
    42051 TTTCTCTTGG TGAACCAGAG ACCACACCTT CAATGGCCAC CAGTCATGGG
    42101 ACAGAAGCTG GCTCAGCTGT TCCAACTGTT TTACCTGAGG TACCAGGAAT
    42151 GGTGACCTCT CTGGTTGCTA GTTCTAGGGC AGTAACCAGT ACAACTCTTC
    42201 CAACTCTGAC TCTTTCTCCT GGTGAACCAG AGACCACACC TTCAATGGCC
    42251 ACCAGTCATG GGGCAGAAGC CAGCTCAACT GTTCCAACTG TTTCACCTGA
    42301 GGTACCAGGA GTGGTGACCT CTCTGGTCAC TAGTTCTAGT GGAGTAAACA
    42351 GTACAAGTAT TCCAACTCTG ATTCTTTCTC CTGGTGAACT AGAAACCACA
    42401 CCTTCAATGG CCACCAGTCA TGGGGCAGAA GCCAGCTCAG CTGTTCCAAC
    42451 TCCAACTGTT TCACCTGGGG TATCAGGAGT GGTGACCCCT CTGGTCACTA
    42501 GTTCCAGGGC AGTGACCAGT ACAACTATTC CAATTCTAAC TCTTTCTTCT
    42551 AGTGAGCCAG AGACCACACC TTCAATGGCC ACCAGTCATG GGGTAGAAGC
    42601 CAGCTCAGCT GTTCTAACTG TTTCACCTGA GGTACCAGGA ATGGTGACCT
    42651 CTCTGGTCAC TAGTTCTAGA GCAGTAACCA GTACAACTAT TCCAACTCTG
    42701 ACTATTTCTT CTGATGAACC AGAGACCACA ACTTCATTGG TCACCCATTC
    42751 TGAGGCAAAG ATGATTTCAG CCATTCCAAC TTTAGCTGTC TCCCCTACTG
    42801 TACAAGGGCT GGTGACTTCA CTGGTCACTA GTTCTGGGTC AGAGACCAGT
    42851 GCGTTTTCAA ATCTAACTGT TGCCTCAAGT CAACCAGAGA CCATAGACTC
    42901 ATGGGTCGCT CATCCTGGGA CAGAAGCAAG TTCTGTTGTT CCAACTTTGA
    42951 CTGTCTCCAC TGGTGAGCCG TTTACAAATA TCTCATTGGT CACCCATCCT
    43001 GCAGAGAGTA GCTCAACTCT TCCCAGGACA ACCTCAAGGT TTTCCCACAG
    43051 TGAATTAGAC ACTATGCCTT CTACAGTCAC CAGTCCTGAG GCAGAATCCA
    43101 GCTCAGCCAT TTCAACAACT ATTTCACCTG GTATACCAGG TGTGCTGACA
    43151 TCACTGGTCA CTAGCTCTGG GAGAGACATC AGTGCAACTT TTCCAACAGT
    43201 GCCTGAGTCC CCACATGAAT CAGAGGCAAC AGCCTCATGG GTTACTCATC
    43251 CTGCAGTCAC CAGCACAACA GTTCCCAGGA CAACCCCTAA TTATTCTCAT
    43301 AGTGAACCAG ACACCACACC ATCAATAGCC ACCAGTCCTG GGGCAGAAGC
    43351 CACTTCAGAT TTTCCAACAA TAACTGTCTC ACCTGATGTA CCAGATATGG
    43401 TAACCTCACA GGTCACTAGT TCTGGGACAG ACACCAGTAT AACTATTCCA
    43451 ACTCTGACTC TTTCTTCTGG TGAGCCAGAG ACCACAACCT CATTTATCAC
    43501 CTATTCTGAG ACACACACAA GTTCAGCCAT TCCAACTCTC CCTGTCTCCC
    43551 CTGGTGCATC AAAGATGCTG ACCTCACTGG TCATCAGTTC TGGGACAGAC
    43601 AGCACTACAA CTTTCCCAAC ACTGACGGAG ACCCCATATG AACCAGAGAC
    43651 AACAGCCATA CAGCTCATTC ATCCTGCAGA GACCAACACA ATGGTTCCCA
    43701 GGACAACTCC CAAGTTTTCC CATAGTAAGT CAGACACCAC ACTCCCAGTA
    43751 GCCATCACCA GTCCTGGGCC AGAAGCCAGT TCAGCTGTTT CAACGACAAC
    43801 TATCTCACCT GATATGTCAG ATCTGGTGAC CTCACTGGTC CCTAGTTCTG
    43851 GGACAGACAC CAGTACAACC TTCCCAACAT TGAGTGAGAC CCCATATGAA
    43901 CCAGAGACTA CAGCCACGTG GCTCACTCAT CCTGCAGAAA CCAGCACAAC
    43951 GGTTTCTGGG ACAATTCCCA ACTTTTCCCA TAGGGGATCA GACACTGCAC
    44001 CCTCAATGGT CACCAGTCCT GGAGTAGACA CGAGGTCAGG TGTTCCAACT
    44051 ACAACCATCC CACCCAGTAT ACCAGGGGTA GTGACCTCAC AGGTCACTAG
    44101 TTCTGCAACA GACACTAGTA CAGCTATTCC AACTTTGACT CCTTCTCCTG
    44151 GTGAACCAGA GACCACAGCC TCATCAGCTA CCCATCCTGG GACACAGACT
    44201 GGCTTCACTG TTCCAATTCG GACTGTTCCC TCTAGTGAGC CAGATACAAT
    44251 GGCTTCCTGG GTCACTCATC CTCCACAGAC CAGCACACCT GTTTCCAGAA
    44301 CAACCTCCAG TTTTTCCCAT AGTAGTCCAG ATGCCACACC TGTAATGGCC
    44351 ACCAGTCCTA GGACAGAAGC CAGTTCAGCT GTACTGACAA CAATCTCACC
    44401 TGGTGCACCA GAGATGGTGA CTTCACAGAT CACTAGTTCT GGGGCAGCAA
    44451 CCAGTACAAC TGTTCCAACT TTGACTCATT CTCCTGGTAT GCCAGAGACC
    44501 ACAGCCTTAT TGAGCACCCA TCCCAGAACA GAGACAAGTA AAACATTTCC
    44551 TGCTTCAACT GTGTTTCCTC AAGTATCAGA GACCACAGCC TCACTCACCA
    44601 TTAGACCTGG TGCAGAGACT AGCACAGCTC TCCCAACTCA GACAACATCC
    44651 TCTCTCTTCA CCCTACTTGT AACTGGAACC AGCAGAGTTG ATCTAAGTCC
    44701 AACTGCTTCA CCTGGTGTTT CTGCAAAAAC AGCCCCACTT TCCACCCATC
    44751 CAGGGACAGA AACCAGCACA ATGATTCCAA CTTCAACTCT TTCCCTTGGT
    44801 TTACTAGAGA CTACAGGCTT ACTGGCCACC AGCTCTTCAG CAGAGACCAG
    44851 CACGAGTACT CTAACTCTGA CTGTTTCCCC TGCTGTCTCT GGGCTTTCCA
    44901 GTGCCTCTAT AACAACTGAT AAGCCCCAAA CTGTGACCTC CTGGAACACA
    44951 GAAACCTCAC CATCTGTAAC TTCAGTTGGA CCCCCAGAAT TTTCCAGGAC
    45001 TGTCACAGGC ACCACTATGA CCTTGATACC ATCAGAGATG CCAACACCAC
    45051 CTAAAACCAG TCATGGAGAA GGAGTGAGTC CAACCACTAT CTTGAGAACT
    45101 ACAATGGTTG AAGCCACTAA TTTAGCTACC ACAGGTTCCA GTCCCACTGT
    45151 GGCCAAGACA ACAACCACCT TCAATACACT GGCTGGAAGC CTCTTTACTC
    45201 CTCTGACCAC ACCTGGGATG TCCACCTTGG CCTCTGAGAG TGTGACCTCA
    45251 AGAACAAGTA AGAATAACTT TTTTATTGTG GTAAAATATA AATACTATAA
    45301 AAATTGCCAT TCTAAACATT TTAATTGTAC AACTCAGCAG TACTAATACA
    45351 TTCACATTGT TGTGCAACCC TCACCACTAT CTGTTTTCAA AACTTTTTTT
    45401 ATCACCCCAA ACAGGACTGA AGGAATAATT TCCCATTCCC CATTCTCCCT
    45451 AGTGCAGTGG TGCAATCTCG GCTCACCACA ACCTCTGAAC CTCTGTCTCC
    45501 TGGGTTCAAG CAATTCTCCT GCATCAGCCT CCTGAGTAGT TGGGACTACA
    45551 GGTGCACGCC ACCGTGCCTG GCTAATTTTT GTATTTTTAG TACAGACAGG
    45601 GTTTTACCAT GTTGGTCAGG CTGGTCTCAA ACTCCTGACC TCAGGTGGTC
    45651 CACACGCCTT GGCCTCCCAA AGTGCTGGGA TTACAAGTGT GAGACACTGT
    45701 GCCCGGCCAT ATCTGTTAGA TCTTACTAAT CCTGTCAAGA GGATTCAGTG
    45751 TCCTTTTTTT TTTTTCTTTC TTTTTTTTGA TAGAGTCTCC CTCTGGCACC
    45801 CAGGCTGGAG TGCAGTGGTA CGGTCTTGGC TCACTGCAGC CTCCACCTCC
    45851 CAGACTGAAG CGATTCTCCT GCCTCAGCCT CCCGAATAGC TGGGACTACA
    45901 GGCGCGTGCC ACCACGCCCA GCTAATTTTT GCATTTTTAG TAGAGATGGG
    45951 ATTTCACTAT GTTGGCCAGG CTGGTCTCAA ACTCCTGATC TCAAGTGATC
    46001 CGCCCAAGGG CCTCCCAAAG TACTGGGATT ACAGGTAGGA GCCACCTCAC
    46051 CTGGCCCTAT TTTCGGAATG GATTTTTTTT TAATGTTTAA AATGTCACCT
    46101 AAGATTATTG TGAAGATCAA ATAAGATAAA ATCCTAATAA CCCAAGTAAA
    46151 CCACAGGGCT CCACTTGGAC CAGTCTCAGA AGTTTCAAGA AAATCAGTCA
    46201 GACCATCAAA TGTAAAATAA GTCTAAATTT TCTTTGCACT ATTCACAGAG
    46251 TGCCAAAGAG GATCTAATTC ATGTTTCAGA ACATACCCTA CTTACTAAAA
    46301 TCCCCTTTTC CTCATTTCTT CTCATTCTGC AACTTTATCA TCTCCTGCGG
    46351 ACCCCCTAGC CTCTCCCCTC CCCATAGTCA GTCTCTCTCT CTCTCTTTCC
    46401 CTCCCCTCTT ATTATCTCAA TTTCACACGA AAGAATTCCA GAAACTATAC
    46451 TGCCAAAAGT CTTTCCTGTC TTTGAAAAGT TGGGAAAGAG GAGAAACTCA
    46501 GACAGCAATG ACAAAATTAT ACGTAATGGA TGAAGGAAAC ACAAATAAGG
    46551 CTGGAAACAG AAAATTTTGT CCCCATCATT TATTTAATGA AGGTGGCAGT
    46601 ATTCCAGCCA CATAGTGAAC CCCCACAATA AGAAGGGGCC TCTGGCGATT
    46651 GATTATTGTC ATTGTTGTTA ATGATAATGA GGGTGAGGAT ATCATGAGCA
    46701 TCAGTGTAGG AGGCAGTTAA CTAATAAGAC CAAGCTGTTG GCTGGGCGTG
    46751 CTGGTTCACA CCTGCAGTCC CAGCACTTTG GGAGGCCAAA GTGGGTGGAT
    46801 CACTTGAGGT CAGGAGTTCA AGACTAGCCT GGCCAACATG GTGAAACCTG
    46851 GTCTCTACCA AAAATACAAA AATTAGTCAG GTGTGGTGGC GTGTGCCTGT
    46901 AATGACAACT ACTTGGGAGG CTGAGGCAGG AGAATCACTT GAACCTGGGA
    46951 GGCGGAGGCT GCAGTGAGAT GAGCTTGAAC CACTGCACTC CAGCCCGGGC
    47001 AACAGAGAGA GACTCTTGTC TCAAAAAACA AAACAAACAA ACAAAAACTA
    47051 AACCAAACAA AAPAAGACTA GCTGTTATTC ATTTATTTAT TTATTTATTT
    47101 AGAGACGGAG TCTCGCTCTG TCACCCAGGC TGGAGTGCAG CGGCACAATC
    47151 TTGGCTCACT GCAACCTCTG CCTCCCAGGT TCATGTGATT CTCCCGCCTC
    47201 AGCCTCCCCA GCTGTTGTTA TTCATGAATG AACCTCAGAG AAAGCACACA
    47251 GGAGGGTTGG TGCACCTGTG TTTTGAGTTC TACCCCTCCT TCCTCTCTTA
    47301 ACTTCCTCCT GTCTTCTCAC TCTGATTCGT TCTTCCTTCC TCTCCCTCTC
    Exon 7
    47351 TCTCTGCAGG TTATAACCAT CGGTCCTGGA TCTCCACCAC CAGCAGTGAG
    47401 TAAACATGGC CCTGAAGTCC CTATGCCCTG GGAATTCTTC CTCCCTAAGC
    47451 CTGCCTTCCA GGAGGAAAGT ATCCCCCATT CCCTAGGTTC TCATCCCCAC
    47501 AGAAACTCCA GAATAGCAAA AGTCTCAGGC TGAGCCAAGG CACAGATGCC
    47551 AGTGCTCACC AAGAGTCCTA TTCTCCCCTC GCTAAATGAT AGGACCCAAC
    47601 AAACCCGATT CACGCTGCGT TTTCTTTCAG CTCCGATGAC CTCCATGTTC
    47651 TCTCCAAGGC CTCTCGTATC TGTGAGCCCC ACCCCCAGCG CTACAGGTAG
    47701 GAATCTGGCT TCCAGCTCCC ATGAAACGTC GGCTGCCATT CAGTGGCTGA
    47751 TTAATTGCTG TGTGGTCTGA GTCCTGATGC CCACCAAGTC TCAGCGTGTT
    47801 CCCCTCTGTC CAATCTCATC CAACAATTTA AGCTAATGCT TGTTTAATGA
    47851 TGTCCTCACT ATACCACCTT GGACACTTTC TTTTTGCCTG GATTTAAAGC
    47901 TTCCATTTCT TTCCTTCCTT CCTTCTTTTC TTCCTTCCTT CCTTCCTTCC
    47951 TTCCTTCCTT CCTTCCTTCC TTCCTTCCTT CCTTCCTTCC TCCTTCCTTC
    48001 CTTCCTTTCT TCCTTTCTTC CTGTCTTTTT CTTTCTTTCC TTCTTTTGGC
    48051 AGAGTCTCAC TCTGTCGCCC AGGCTGGAGT GCAATGGTGC AATCTCGGTT
    48101 CACTGCAACC TCTGCCTCCC AGGTTCAAGC GATTCTCATG CCACATGCCA
    48151 CTATGCCTGG CTAATTTTTG TTTTTTTGTT TTTTGGGGGG TTTTTTGAGA
    48201 CAGAGTCTCA GTCTGTTGCC CAAGCTGGAG TGCAGTGGCA TGATCTCGGG
    48251 TCACTGCAAC CTCCTTCTCC CAGGTTCAAG CGATTTTCCT GCCTCAGCCT
    48301 CCTGAGTAGC TGGAACTACA GGCACGCACC ATCACACCGG CTAATTTTTT
    48351 GTGTTTTTAG TAGAGACGAC GGTTTTGCAA TGTGGGCCAG GCTTGTCTCG
    48401 AACTCCTGAC CTCAAGTGAT CCTCCAGCCT CGGCCTCTCA AAGTGCTGGG
    48451 ATTACAAGTG TGAGCCACTG CACCAGGCCA AAAACTTGTA TTTCAATAGT
    48501 CATTGAGGCT GGGTGCAGTG GCTCACGCCT GTAATCCCAG CACTTTGGGA
    48551 GGCTGAGGCC AGTGGATCAT GAGGTCAGGA GATCAAGACC ACCCTGGCTA
    48601 ACACAGTGAA ACCCCATCTC TACTAAAAAT ACACACAAAA ATTAGCCGGG
    48651 CATGGTGGCA AGATGCCTGT AGTCCCAGCT ACTCAGGAGG CTGAGGCAGG
    48701 AGAATGGCGT GAACCTGGGA GGCAGAGCTT GCAGTGAGCG GAGATCGCAC
    48751 CGCTGCACTC CAGCCTGGGC AACAGAGAGC GACTCTGTCT CAAAAAAAAA
    48801 AATATATATA TATATATATA TATATTCATT GAGACCGACT CTGACTTAAA
    48851 AGCAGTAATG AATGGTGTAG GTTTTGGTAA ATTACAGGTC TTGCTTTAAG
    48901 TCCTGGTCCT CTCTTTTGCT CACTGTGTGG CCCCGGAAGA GCCATGTAAC
    48951 CTCTCCAGGC TTCAGTGTCC ATTTTTAGAA CGGAGTAAGT GAATAAGCTG
    49001 TGTCCAATCA TCTCTGGCCA TATCAGCTTC ATTTTTTTTT TCCTCCAGGG
    49051 TCCAAACATC CCTCCACCCT CAGAGTCTTT GCACCTGGTG TTCTTGTCCT
    49101 TCAAATCTCA GCTTGGATCA CCCTTTATAA AGTAGCATTT CCCCCGTATA
    49151 CGCATCTTGC ACACAGCCAA TCTCTATTCT ACCTCTATGC TCACTTCCTT
    49201 CCTGGCAATT ATTACTACAG CTGGGCCCTT GAACAGCATG AGGGTTCAGG
    49251 GTGCTGACCC CTATGCATTC AAAAATCCAC ATATAACTTT TTTTTTTTTG
    49301 AGATGGAGTT TCACACTTGT TGCCCAGGCT GGAGTGCAGT GGCGCCATCT
    49351 TGGCTCACTG CAAACTCTGC CTCCTGGGTT CAAGTGATTC TCCTGCCTCA
    49401 GCCTCCTGAG TAGCTGGGAT TACAGGCATG TGCCACCATG CCCAGCTAAT
    49451 TTTGTATTTT TAGTAGAGAT GAGGTTTCTC CATGTTCGCC AGGCTGCTCT
    49501 TGAACTCCTG ACTTCAGGTG ATCCGCCTGC CTTGGCCTCC CAAAGTGCTG
    49551 GGATTACAGG CATGAGCCAT GATGCCCGGC CATTTGCTAA TGGCATCTAG
    49601 TAAGTAGAGG CCAGAGATGT TGCAAAACAT CCAACAATGC ACAAAGCAGC
    49651 CTCCTATCAA AACACATTAT CCAGACCAAA ATGTCAATAG GGCTGAGGTT
    49701 GAGCATCTGC TGTACACAGA TTCCAAGTTC TGGTACAAAT CTCGTAGTTC
    49751 TCTGAGGGCT CATCTTTCAA TGCCTAGCAC ATCAAAGGAG GCCAATTTCC
    49801 TCTTCCCTTT CACCTCCTGG TATGAAATGT TTCCTCCTCC ACCTTGATCC
    49851 TGTAAGAGCC CAGCTGGAGT TTGCAGACGA CGGGGAAAGA AATGGGTGAG
    49901 GGAGGGTCCT ATGGTTGAGT CTCCOCAGTG GGCCCTGGGT GCCCAGTTCA
    49951 CCCTCCTCCC CTTCATTTTC TCCATCATGA CAACTCAAGG CAAATTCTCA
    50001 GTTTCCATGG GCCAGTGGAA TCCACTGACT TCATGAAATA ACCCCACCCT
    50051 GAGCAAATAC CCCTCAAATA ATAACTGTTT ACACAACATC AGTGGCAACA
    50101 ATGACCCAAG CAGCAATGCC ACCACCAGAA TAGCAACCAT AACAGCAGCT
    50151 CATTTTCATC AAAAGGAAAC TGTAGGGCCA GGCACAGTGG CTCACACCTA
    50201 TATTCCCAGC ATTTTGGGAG GCTGAGGCAG GCAGATCACC TGAGGTCAGG
    50251 AGTTCAAGAC CAGCCCAGCC AACATGGTGA AACCCCATCT CTACTAAAAA
    50301 TACAAAAACT AGCCAGGCTT GGTGGCATGT GCCTGTAATC CTAGCTACTC
    50351 GGGAGGCTGA GGCAGGAGAA TTGCTTGAAC CTGGGAGGCA GAGGTTGCAG
    50401 TGAGCTGAGA TTGTGCCACT GCACTCCAGC CTGGGCGACA GAGCAAGACT
    50451 CCGTCTGAAA AAAAAAAAAA AAGGAATTGT GCCAGGAATT GTGATGAGAA
    50501 CTTTATATGC ATTATCTCCT ATTAATATTA CCCAAACCTC CGTGAGTTAG
    50551 TATACTCATT TCTACAGAGA GCATTTATGC ATCCAGGGAG GAAGTAATTA
    50601 GCCCAGAATT ACTCAGTTAT GACACAGGAC AGTATGAAAA CTCCAACCGA
    50651 AGATTGGAGA CTCATGAAAA CTCCAGGCTC CTAACTACAA GACATCACTG
    50701 TGGATCGTCC AAATAGAGCA AGCCCCAATC TCAGGACAGG AATGAGGCAT
    50751 GAATGGCCTC TATGCTAATG ATCTAACCTA ATGCTGAATT TGTTACTTCC
    50801 CTTCTGAATC CACTTGGAGA TTTCCTTTAT ATCTGACTTG AAATAGAGGA
    50851 TATATACTCC TCTATCCTTG ACATAGGAGA TAATACACAG AAAGTATTTC
    50901 ATTGTAGTAT CAAGTACACA TCCTGTTCTG TGTCCATAGG ATTATGACTA
    50951 ATTTAGGGCA TGGCTTAACA GTGTGGTACT ATTGAATGAC AGACAGATGT
    51001 CTGTTTTGTT GGATGCAGGA CAAGCCATGT AACCTCCCCA GACTTTAGTG
    51051 TCCCCTCTGT GGAATGGAAT AAAAATACTA CGTGGGATTG TTCTGATAAT
    51101 CAAATGAGAT AATTCAGGAA CAACCCAGAT AAATAACAGG GCTGCCCTGG
    51151 GTTCTGTCTT TCCTTGTATC TCTCACAGAG CCTCAAAGGA GATGCAATCC
    51201 ATGACCTAGA GAAACACTCA GGACAAATTC TCTTTTCCCC AGTTCCTTTC
    51251 TTGCTCCAAT GGCAACACCA CCCCTCTCAT CCTGAAGTCT CTTGTTTTTA
    51301 CCACCACACC TATTTTGCCA AATTTTCTCC AATATTCCAA ACCATATGAA
    51351 ACCTTTCTTT CTTTCTTTTC TTTCCTTCCT TTCCTTCTTT CTTTCTTTTT
    51401 TCTCTTCTTT TCTTTTCTTT TTGAGACATG GTCTCACTCT GTTGCACAGG
    51451 CTGGAGTGCA ATGGCACGAT CTTTGCTCAC TGCAACCTCC GCCTCCCAGG
    51501 TTCAAGAGAT TCTCTTGCCT CAGCCTCCTG AGTAGCTGGG ATTACAGGCG
    51551 CCCACCGCCA CGCCACGCTA ATTTTTGTGT TCTTAGTGGA GACGGGGTTT
    51601 CGCCATGTTG GCCAGGCTGG TCTTGAACTC CTGACCTCAA GTGATTTGCC
    51651 CATCTCGGTC TCCCAAAGTG CTAGGATTAC AGGCGTGAGC CACCAAGCCC
    51701 GGCCCCATAT GAACCGTTTC TATCCCTCAT TTCTCTGTAC TTTTACCTAA
    51751 AAACACCACT CCCTTCACCC ATCACATTTT TGTCAATTCT ACATCACACA
    51801 CACACACACA CACACACACA CACACACAGA GAAAGTAAGT TGGAAAAAAA
    51851 TTATACTATC ATGAAATTTT GTGAAAGGAG GTAAGCTGAG AGAGTAAGAA
    51901 TCAAACTAAA TTATCTTTAT GGGTAGAAAG CACACTCATC CATACATGTG
    51951 TCTTTCCACC CTTGTAATGT ATTTATTATT ATTGTTTGTA TATACTAGAT
    52001 TCCCAATAAA TAGGGACAGC TATTATGGTA TTTTTATTTC AGGAATAATA
    52051 ATAGTGATGA TTTCCACCAT TATTGTCAAA GGACAAAGCA CAAAATATGT
    52101 ACCAAATAAA ATATAGCCAT TATCCTTTAT TCACAAAAGA TCTTGGCCCC
    52151 ACCTCTTCTC AATGAAATGT CCATGACTTG TTCAACTTTG GCCACTCTGG
    52201 GCTGAGAGAT GGAGGTTCCC TTGCGAGCTG AAGTCACACA TCGAAGGTGG
    52251 AAGCCCCTCC CCTCCCTCTG GCTGGCTGAG GGATAGCCCA GATGGGCTCA
    52301 TCATGAAAGT TTCCCATTAT TTCCATTTCT GGATCTACCA TCTTCCCCTC
    52351 CCCTACCTCT CACCCATCAT AATTGTCCTT CTTTACTCTT TCCTCCCTAT
    Exon 8
    52401 CTGCAGGTTA TAACCGTCGG TACTGGACCC CTGCCACCAG CAGTGAGTAT
    52451 TCAAACCTGT GATATTCCAA TGCCCTTGGG ACCCTTCCTC CCCAAGGTGC
    52501 ATTCCTCAGA AGAGAAACTG ATCATTCTCC CTCCCTACGT GCCCAGCCAC
    52551 AGCCTCAGAG CAGCCCCTAA CCCGTCAAGG TCTTGGTGTG AGTCAAGATA
    52601 GAAGTCCAAA TTCCAATGAG CAGTTCCTGT CCCATATTCC TTTAGGAAGA
    Exon 9
    52651 CACCCAATCA TTTCTCCATG TTCTTTTTTT CTCAGCTCCA GTGACTTCTA
    52701 CATTCTCCCC AGGGATTTCC ACATCCTCCA TCCCCAGCTC CACAGGTAGG
    52751 AAGCTCCTCT CTGGCATCTA TGAAATTTAA CACTGCATGG TCTGTTCCCT
    52801 GCTGACCACC CAGACTCAGC CTGTTCCACT CGCCCTCTCA CTCTCTCTCT
    52851 CTCTCTTTTT TTTTTTTTTT TTTTTTTTTT TTTACGGAGT CTTGCTCTGT
    52901 CACCCAGGCT GGAGTGGAAT GGTGTGATCT CGGCTCACTG CAACCTTCGC
    52951 CTCCCAGGTT CACGTGATTC TCCTGCCTCA GCCTCCGGAG TAGCTGGGAT
    53001 TACAGGTGCA CACCACCATG CCTGGCTAAT TTTTTGTATT TTTAGTAGAG
    53051 ACGGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTCC TGACCTCAAG
    53101 TGATCTACCC ACCTTGGCCT CCCAAAGTGC TGGGATTATA GGCATGAGCC
    53151 ACCACGCCAG GCCCACTCTC TAAATTTTGA CCACCCTGCC TTGAGTGGTC
    53201 TTCTAGCACC CTAACCTCTG TCTAACCTCG AGAGCTTTGC ACTAGCGATT
    53251 CCTGGGGACC AGCTATGGTT GGTATCTTCT CAACTTTCTA ATTTTTTTAA
    53301 AATTATTATT ATTATTATTA TTATTTTAAA TGGAGTCTCG CTCTGTCACC
    53351 CAGGCTGGAG TGCAGTGGCA CCATCTCGGC TCATTGCAAC CTCTACCTCC
    53401 CGGGTTCATG CAATTTTCCT GCCTCAGCCA GAAATTTTCT CAGTGGTCGA
    53451 GATTGTGCCA CTGCACTCCA GCCTGGGCAA TGGAGCTAGG CTCCATCTCA
    53501 AAAAAAAAAA AAAAAAGACG GAGGTCGGGC ATTCCTAACC CTTAACCCTG
    53551 CCTTGTGATT CTGGAGTTAT GAGATAGAAC CTGGTGTCCC GTAATTAAAA
    53601 TTCCGCCTTC AGGCCTTATG TTTTGTGAGT CACAACACTG CAAACTTTTT
    53651 ACATGCTGTA GACAGGATGT TCACTCTCCA CTTCCTCACT GCTCTGCTCT
    53701 AATCAATTCA ACCATTTATG TGACATGCCT AACCCCTCTG GGCTTGTACG
    53751 TATGTAACAT GTATTACAAA GCAAGTCATT CCATGATCAA TGCTGTCACT
    53801 TTTTCTAGGT GCTTTCAAAA TTTGTTCTTC ATCATTGATT TTCAGTAGTT
    53851 TGATTACGAT GTGTCTGGGC ATGGTTTTCT TTGAGTTTAT CCTGCTTAAA
    53901 GTGTTCTCAG CTTCTTGAGT CTCAAAGTGT TTATTTTCTG CTCTGATTCT
    53951 TTCTCCCCTT CGGACCTCCA ATGPAATGAT GTTGCCCGAA GAGACCCTGA
    54001 GGTTCTGTTC ATTTTGTTAT TTATCAATCT TTTTTCCTCT CCGAATTTCA
    54051 GGTTTAATAA TTTTTTTTTT TTTTTTGAGA CGGAGTCTCG CTCTGTCGCC
    54101 CAGGCTGGAG TGCAGTGGCG CGATCTCGGC TCACCGCAAG CTCCGCCCCC
    54151 TGGGTTCACG CCATTCTCCT GCCTCAGCCT CCGGAGTAGC TGGGATTACA
    54201 GGCACCCGCC ACCATGCCCG GCTAATTTTT TGTATTTTTT AGTAGAGACG
    54251 GGGTTTCACC GTATTAGCCA GGATGGTCTC AATCTCCTGA CCTCGTGATC
    54301 CGCCCGCCTC AGCCTCCTAA AGAGCTGGGA TTACAGGCGT GAGCCACTGC
    54351 GCCCGGCCCA GGTTTAATAA TTTTTATAGA ATATTTTCAC AATCACCAAG
    54401 CCTTTTCTCT ACCAGCTCCA TTCTGCCCAT CCATTGAATT CTTTTTATCT
    54451 CAGTTACTTT ATGTTTCAGT TCGAAAGTTT CTACTTGGTT AGATAGATAG
    54501 ATGTTATATC ATATATTATA TGTTATATAA AAATATATTT ATGGTTATAC
    54551 ATATAACATA TATGTTATAT ATAGTTATTT ATATAGCCAT AACTATATAT
    54601 AGCCATATAT ATAGTTATAT ATAACCATAT ATATAGTTAC CATATAGTAA
    54651 CCACATATAT AAAACATATA TATATAGTGT CTCTCTATAT ATAGTTATAT
    54701 ATATAGTTTC TATATCTGTA ACTATATATA GTTATATATG TATGTTTCTC
    54751 TGTATATAAA TATATATATT TCTATATATA TAGTTATACA CATTATATAT
    54801 ATAACTGGGA GATGTTGGTA AAGGATGGCG TGAGGAAACC TGGAGCAGTC
    54851 ATGGTAATCC TCGCTCTGCT CCGAACTCCT CAAGAGCAGG AGAAGGGTCC
    54901 TCCTCATTCT CCAGCCATGT TGACTTTGAG CAATTTACTC ATCCTCTCAG
    54951 TACCTCAGTT TCCTCACCTG CCAATTGAGG ATAATAATAT TTCATAAATT
    55001 GTTTGCAAAT GTTATATGCA ACTCTACGTA AGAACACCTA GCACAGGGGC
    55051 TACCAGGGAA TTTGGTTTAA CAAATATTTA TCAGGCACCT ATTCTGGGCT
    55101 GGGCAGGGGG GATAAGATGT TGACTAAGTC AAATGCAGTC CCTCCCCTCA
    55151 CCAAGTTTAC AGTGTATTGG GCAAGACTGA AATGGAACAA GCAATTACAA
    55201 TTGACAATAA AAGACAACCA AGTTATTGAG CACTTACTAT ATGGCATGCC
    55251 ATATGCTATG TATTTTTTTT ATTTTTAACT TTTCATTTTG AAATAAATAA
    55301 TAAATATAAA GTAAATAATA ATATAAATAA ATAATAAATA ACTTTTCATT
    55351 TTGAAATAAA TAATAAATAA ATTCAGGAGA TGTTGCGAAA ATAGTGTAGC
    55401 ATTCCCCTGT ATCCTTCACC CAGTTTCTCC CCAATGGCTA CATCTTACAT
    55451 AACTCTAATA CAATATCAAA AGCAGGAAAC TGACATTGTT AAAATCCATT
    55501 TTACTGGTTT TACACGCGTG TGTGCATATG TGAGCTTGTG TATGTGCGTG
    55551 TGTGTGCAGG CATGTGTGTG CATGCACGCC TGTGTGTGCA TATGTGCATG
    55601 TGTGCATGCG TGTGTGCATG TGTGCATGTG TGTGTGCATG CGTGCGTGCG
    55651 TGCGTGCATC TGTGTGCATG TATGCACATG TGTGTGTGTC TGTGCACGTG
    55701 TGTGCATGCA TGTGTGTGTG CGTGTGTGTT GGTAGCCCTA TGCAATTTTT
    55751 ATCACATGGG CATAGCCCTA TAATCACCAC CACCATCAAG ATTCAGAACT
    55801 GTTCCATTCC CCCAAAGATT CCCCTCATGC TAGCCTTCGT AATCATGCCC
    55851 ACTGAGCCCA ACACTATTGC ATAGAATAGC TATTCTACTC TCCATCTCCA
    55901 TCTCTGTCTC TACAATTTTC TTTTGAAGAT GTTATATAAA TGGAAATGTA
    55951 CAACATGTCA CCTTTGAAAT TGGCTTCTTT TCCACTCAGT GTAATGCCCT
    56001 GGAGATGTGC TCTTTTTAAC AGTCATGTAA CCTTCCTAAT TTCCCTCCAA
    56051 AATATCATTA TGCCCCTCGC CGCCTTTTTT TTTTTTTTTT TTTTTTGAGA
    56101 CAGAGTCTCG CTCTGTTGCC CAGGCTGGAG TGCAGTGGTA TAATCTCAGC
    56151 TCACTGCAGC CTCCGTCTCC CGGGTTCAAG GGATTCCCCT GCCTCAGCCT
    56201 CCCAAGTAGC CAGGATTACA AGTGCATGCC ACCACGCCTG GCTAATTTTT
    56251 GTATTTTTAG TCGAGACGGG GTTTCATTGT GTTGGCCAGG CTGGTCTCGA
    56301 ATTCCTGACC TCAAGTGATC TGCCCGCCTT GGCCTCCCAA AGTGCTGGGA
    56351 TTACAGGTGT GAGCCACCGC GCCCGACCCA TATTGCCCAT TGTATTACAG
    56401 CGGAAGAAAC TGAGGTATGG ACAGGTAACA TGTCCATGGT CACTTGGCTG
    56451 GTGAGGGGCA GAGAGGAGAT TTGAAACCAA ATCTGACTCA CTAGTGTGGC
    56501 CGTAACCATG GTAACTATGT CTCTCTACCA TGTGGTCTCC TCTTTATTAA
    56551 AGGAAGGGCA AGTTCTGGGA GTTTTGGGAG TTTTGGGCTT GAGTGGGGAA
    56601 GGGTAGCCAA GTAAAGCAGG TGAGAGAAGG TCTGCTTTAA GGACTGCTGT
    56651 TTGATTTTTA TTGTTGTTGT TCAGTGTTCA ATGGGATTGA GTTGACTCTT
    56701 TTTTCCCTTC TTGTTCCCCA AAGCATGAGA CTGTTCCGGT CCTTTTCCCT
    56751 TTTAACTTCT CAGCTAGAGT TTGTTAGGGC GGGTATGGGC ACCTGGCAGA
    56801 GTCTGAGACC TCAGCTTCCA GTAGGCACAC GTTCTGACCC AATACACCTA
    56851 CCCTGGTCCC CTAACCTGCT TCTGGTCCCC TAACCTGCTT CTGGGCCCAG
    56901 GTAATGCATT TTAGGAACAT CCCACTTTTC TCCTTACCTG GCTTTCCATT
    56951 ATCCGTCCAA ACTAAAGCAC CCACCTGTCT GCTTCAGACT CTTGCTTCAA
    57001 GCACTCCGTC TGGGTCCTCA GAAATTGACT TACAGTCAGT TCAGATCTGA
    57051 CTCAGGCGTG GCCTTCTTTT CTCCTTCCTT GC
  • [0054]
    TABLE 2
    Genomic Repeats
    (SEQ ID NO: 2)
    Exon R1
      1 AGCAGCCACA GTCCCATTCA TGGTGCCATT CACCCTCAAC TTCACCATCA
      51 CCAACCTGCA GTACGAGGAG GACATGCGGC ACCCTGGTTC CAGGAAGTTC
     101 AACGCCACAG AGAGAGAACT GCAGGGTCTG GTGAGAGCCC CGCCCACCGT
     151 ACTCCTCCCT CGCCCACTTA GACAAACCAG CCCACCTCAC ACTGCCTCGC
     201 CCACTGATGC CAGCCACGCC CACCTCATCC AACCCCAGAC ACCTTTCCCT
     251 GCCCCACCCA CTGATTTTAG CCAAGCCCAC CTCACCCCAC CCAGCCTACT
     301 GATGCCAGCC ACGCCCACCT TTCCCTGCCC CGCCCACTGA TTTCAGCCAC
     351 GCCCACCTCA CCCTGGTCCA CCCCTCCAAT GCCCCACTCT TCCTGGCTTC
    Exon R2
     401 CCGCAGCTGT TGTTTCTCAC CTCCCCTCTC CTTCCTTGCA GCTCAAACCC
     451 TTGTTCAGGA ATAGCAGTCT GGAATACCTC TATTCAGGCT GCAGACTAGC
     501 CTCACTCAGG TGAGACGCTC CTTAAGAAAA ACACAGCCCA ACAGGTGAAT
     551 ATGACCCTAG TCTCTGGGCT CCCTGACTCT GTTCATACTT GGAACAACTA
     601 TTGCCCATGG ATACTAAGCA TCACCACCAG CAGCAGCAGA TAACTATTCC
     651 TAAGACCCAA GGCACTGCAT TATGTACTTT ATATTTAATG CCTCATCAGT
     701 GCTTGCAACA GCCTCATGAA GCAGGAGCAG AAGGGGAAAC TGAGGCCCAG
     751 ATTAAGTGGC TTGTGCCAGG ACACACAAAG CAACTGCAGC ACTTCAGGTT
     801 CTATATCCAA ACTCCTATCC CTTAGGTGGC ACTTCCTCCT CTGCCCCCAT
     851 TATGAACTTG CAGCATGTGG AAAACCCCAA TCTGACTTCC CTCTAAGGGA
     901 ACTTGCCCAG AGAATCTAAG AGGGGAGGAA AGGAAGGCGT TCAGCCCTTA
     951 CAGGCAGGAG GTCAGCTCCT GAGTGGCTCA GATGCAGCCA CAGAGGGCCT
     1001 GGCCGGTCTG AGGGTGACTG AGAGGCACCG AGGGCACTGT CCCTGAGTGC
     1051 TGGAAAGGGC AGGTCTTTTA GGGTAGACAG CGGTTGATAT CATTTCCTGC
     1101 CTGGCATTCT CACCTTCCAC ACCTCTCTCA CAGAATCTCC AAGTGTGGCT
     1151 CTCCCAAGAG AGAGTGTCAG TCATCTACCT CCAGCTTCCT TTCCTTCCCA
     1201 GGGGGAAGAG GGGACAGGGG GGCCCTAGTG GCTAAGAGCA TTGGTGAACT
     1251 CAGGCAGACC TCAGTTCTGA ACCAACCCAG CTCTGCCATT TACTATCTGT
     1301 GACTCTGAGC AAGTGCCTGA AGCCTTCTGT GCCCTATTTC CTGACATATT
     1351 ATATATATAA AATACATATA TTATATATAG ACATATTTTA TATACATATT
     1401 GAGGCATATT TTATAAACAT GTTTATAGAC ACATTTTTAT ATGCATATGT
     1451 TATATACGTA TATAACATAT GTTATATATA ATGTATATAT TATACATATT
     1501 GTTATATTGT ATACATGTTA TATATGTTAT AGCATATATA GTACAAGTTA
     1551 TATATAACAC ATACATTATG TTACATATAA TGTATATGTT ATATATGATA
     1601 TATTATATAT AATTATATAT TATATAAAAC TGTTATATAT AATTATATAT
     1651 AATATATAGT TGTTATATAT AATTATATAA TTGTTATATA TTATATACAA
     1701 CATATAACAT ACATTATATA TTGTTATATA TAATATAATA TATACATATA
     1751 TAACATATGT ATAACTTTTA TGTTATACAT AATGTATATA ACATATATGT
     1801 GTATGTGTGA TGTACATAAC ATATCTGACA TTAACATATA ACATATGATA
     1851 TAACAATATT ATATGTTATA ACATAATATA TGTTATAATA TAACAATATT
     1901 ATATGTTATA ACTTATACTG TCATATGTAA CATATACATA ATATTTTATA
     1951 AATCAGTTTA ATATACATTA TGTTACATAT AATGTATGTT ATATATGATA
     2001 TATTATATAT AATTATATTA TACATAATTG TTATATATAA TGCATACATT
     2051 GTATTTGTTA CGTATTATAT GCAACATATG GGGATCCTCT AGAGTCGGAC
     2101 CAGCGGCAGC AGCTGCCTGC CTTTTNNNNN NNNNNNNNNN NNNNNNNNNN
     2151 NNNNNNNNNN NNNNNMNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     2201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     2251 ATATACATAC ATAACATATG TATAACTTAT ATGTTATATA TAAGTATATA
     2301 ACATATATGT GTATGTGATG TATATAACAT ATCTGACATT AACATATAAC
     2351 ATATGTTATA ATATGACATA TTATATATAT TACATATAAC GTATATCATG
     2401 TATAATATAA TGTGTATATA TAATATATTA AAGTATATAA GTATAAATAC
     2451 ATGTAATATT TAAATATATA TTATATATAG TATACATGTG GATACATACA
     2501 ACTTCTACAT ATACCTAGTA TATATTCTAT ATATAAACAG TCCATGAATT
     2551 ACAATGATTC AACTTATGAT TTTTCAAACT TTGTGATAAT GCCATAGCAA
     2601 TATGCATTCA GTAGAAAGCA TACCTTCAAC ACCCATGCAA CCATTCTGTC
     2651 ATTCACTTTC AGTACAATAT TCAATAAATT ATATGAGATA TTCAACAGTT
     2701 TATTATAAAA TAGGCTTTGT GTTAGGTGAT TTTGCCCACA TGTAGGCTAA
     2751 TGTAAGGGTT CAGAGCATGT TTAAGGTAGG ATAGGCTAAC CTATCATGTT
     2801 CTGTAGGTTA GGTATAGTCG ATTTTTATTT TTATTTTTAT TTTTGAGACA
     2851 GAGTCTTGCT CTGTCACCCA GACTGGAATG CACTGGTGCG ATCATAGCTC
     2901 ACTGCAGCCT TGAACTCCTG GGCTCAAGTG ATCCTCCTAC CTCAGCCTCC
     2951 TGAGTAGCTG GGACTACAGG TGTGTGCCAC CACACCTGGC TATTTTTTTT
     3001 TTAATTTTTT TTTTTTTGTG GAGAGGAGGG TCTTGCCATG TTGCCCAGGT
     3051 GGCCTTGAAC TCCTGGGCTC AAGGAATCCT CCCACCTTGG CCTCCCAAAA
     3101 TCCTGGGATT ACAGGTGTGA GCCATCACGC CCGGCTACAG GGCATTTTTG
     3151 ACTTATGACA TTTTCAGTTC ACAATGGATT TGTCAGGGCT GGGCATGATG
     3201 GCTCACACCT GTCATCCCAG CACTTTGGGA GGCTGAGGCA GGTGGATCAC
     3251 TTGAGGCCAG GAGTTTGAGA CCAGGCTGTC CAAATGGCAA AATCTTGTCT
     3301 CTACTAAAAA TACAAAAATT AGCCAGGCGT GGTGTGACAA CTGTAGTTCC
     3351 AGCTACTCGG GAGACTGAAG CGTGAGAATC ACTTGAACTT AGGAGATGGA
     3401 AGTTACAGTG AGTCAAGATC ACACCACCGC ACTCCAGCCT GGATGACAGA
     3451 GCAAGACTCT TGTCTCCAAA AAACAAAAAA CAGGCTGGGT GCATGGCTCA
     3501 TGCCTGTAAT CCCAGCAGTT TGGGAAGCTG AGGCAGGTTT ATCACCTGAG
     3551 GTCAGTAGTT CACGATCAGC TTGGCAAACA TGGAGAAAAC CCATCTCTAC
     3601 TAAAAATACA AAAATTAGCT GGATGTGGTG GTGGGTACCT GTAGTCCCAG
     3651 CTACTCGGGA GGCTGAGGCA GGAGAATGGA TTGAACCTGG GAGGCAGAGG
     3701 TTGCAGTGAG CCAAGATCAC ACCATTGAAC TCCAGCCTGG GCAACAGAGT
     3751 GAGACTCCAT CTCCAAAAAC AAAAGAAAGC AAAAACAAAA AAATAAAATA
     3801 AAAAACCTGT GTTTATCAGG ACATAATACC ATCATGAGTC AAGAAGCATC
     3851 TAAATGTACA TGGTAGTTAT ATAAAAATAG TTATATAGTT ATATACAATA
     3901 GTTATATATA AACCAGTTTA ATATATGTTA AGTAGAGGTA TATGGTAGTT
     3951 ATATAAAAAA TAGTTATATA ATAGTTATAG AGTTATATAA TTATATAAAA
     4001 TAGTTATATA TAAACCAGTT TAATATATGT TAGGTAGAGG TATAATAATA
     4051 TATATTGTAT ATACTATATA ATATAGTAAT GTATAAAATG CAAAACGATA
     4101 TCATATATTT CTATATTAAG TTTATATTTA CAGATCTACA TTTTATATAT
     4151 TTTATGTTAT ATACAATTGT GTTATACATA ATATAATTAG TATAGTACTG
     4201 ACTTGGGGAA TTGAGCAGTA CCAACCCATA GGGATGTTTG AGGATGAAAA
     4251 TATGTGATTA TGAATACAAA ATGCTGGGCC TGCTGCATAG GAAGTATTTA
     4301 ATAAATGGTA GTTGTTACTA TAAAGTCGTT CCTACTATAG AGCTACTCAC
     4351 AACCTGGGAC ATAGGGAAAG AGCCCGTTTC CCTCTAATCA CTCAATAGTG
     4401 GGTGGCTAGG TAGGTGAGTC CACATCCTGT GGCCGGGAAC AGGTGCTGAG
     4451 ACATGAAGAC CTTCTGACTG CATGTTGGAC CAGCCACAGT TTCAGACGGA
     4501 CCAGCCAAAA AGGGCATTTT CCCCAAGCCA TTTAGCTCCC TTGAGTCTCA
     4551 TAACAAATCT CCTAGACCCT GCTGGTCCAT AGGATCTAGA GAGGATGACT
     4601 TGAACCTTCT GATCCCACCA TTTGAAAACG CCATGCCATG GGCACCAGTA
     4651 GGAGGGCCAC TGCTACGTGC ACCAGTACAA GGGCCACTGC CATGGATTAC
     4701 AGATTAACCC TAAGTATAGC TGTCGCACAC CTAGTACTTC AGGAGGCTTA
     4751 TTCGGGGCCA TGCAGATCCC TGGCATTATT ATCCTAGGAT CCTACACCAA
     4801 GCAAAGCAGG AGCTGCCCCT CCTCATAAAC CCATAAGCCC TCCTCTTGAG
     4851 CAAAGCAGCT GGGAAGGCCA GAAGTTATTC AAGCTCCCCT CTGCCCCGGT
     4901 TCCAAAGACA GACAGCTCAA GCCTACATGC AGCAAACCCT ATAAAAGTGT
     4951 CACCTCTTGG CATTTCTGCC ATGGTAATGC TTTCTGCTTC CACTAATAAT
     5001 CCTAGTAATT TGTTTATGGT GGGCATCTCT CTGATGAGAA CCACATTCTT
     5051 TTTTTTTTTT TTTTTTTTTT TTGAGATAGA GTCTCACTCT GTTGCCCAGA
     5101 CTGGAGTGCA GTGGCGCGAT CTCGGCTCAC TGTAACCTTT GGCTCCTAGG
     5151 TTCAAGCAAT TCTCCTGCCT CAGCCTCCCA AGTAGCTGGG ACTGCAGGCA
     5201 CGTACCACCA TGCCCAGCTA ATTTTTGTAT TTTTAGTTGA GACGGGGTTT
     5251 CACCATGTTA GCCAGGATGG TCTCAATCTC TTGACCTCAT GATCCACCTG
     5301 CCTTGGCCTC CCAAAGTGTT GGGATTACAG GCATGAGCCA CCATGCCTAG
     5351 CCTGAGAGCC ACATTCTTGT TAACCACAAT TTTCTCAGAG TCTGCATTAG
     5401 GGGTTGACAA AGAGTGGAAA GGAAGGACAA AAGGATGGAG AGGTGGATGG
    Exon R3
     5451 ACTAAGCATA TGTAGGTTCT TACCCAGGCC AGAGAAGGAT AGCTCAGCCA
     5501 CGGCAGTGGA TGCCATCTGC ACACATCGCC CTGACCCTGA AGACCTCGGA
     5551 CTGGACAGAG AGCGACTGTA CTGGGAGCTG AGCAATCTGA CAAATGGCAT
     5601 CCAGGAGCTG GGCCCCTACA CCCTGGACCG GAACAGTCTC TATGTCAATG
     5651 GTGAGCAGCT GTGATGTGGT TGGAGGCTCT TCCTCCTTGC TGAGCAGCCT
     5701 GTAATCACTG GCTTGAGGTC ACACTCACTG TCAGGCAATT GAAAATTTGG
     5751 TCCTGTGCTC TACATGGGAT GACTAATTTC CGGACTTCAT GGTATCTTTT
     5801 TTTTTTTTTT TTTTTTTTTG AGATGGAGTC TCGCTCTGTC ACCAGGCTGA
     5851 GGTGCAGTGG CATGATCTCA GCTCACTGCA ACCTCCGCCT CCCGGATTCA
     5901 AGCAATTCTC CTGCCTCAGC CTCCTGAGTA GCTGGGACTA CAGGTGCATG
     5951 CCACCACACC CAGCTAATTT TTGTATTTTT AGTAGAGACA GGGTTTCACC
     6001 ATGTTGGTCA GGATGGTCTC AATCTCTTGA CCTTCTACTC CACCTTGCCT
     6051 TGGCCTCCCA AAGTACTGGG ATTACAGGCT TGAGCCACCA CACCTGGCCA
     6101 GGACTTCATG GTTTCTTCAT CATCATGGAA TGAATTCCAT CAGGGCATTC
     6151 TTCCCTGATG TGAGGGCACT GATAGGAAAT CTTTAATGGT CCCTGCTGCA
     6201 TGAAACTGCT TCCATTGCAC CAGGGTAGCC CTGACCCCTA TTTGGTCCCC
     6251 CACATCTCCT TGTAACTTAC CCACACTCCT CCCTCCTTCT CTGTGCAGGT
    Exon R4
     6301 TTCACCCATC GAAGCTCTAT GCCCACCACC AGCAGTGAGT ATTCAACTCA
     6351 TGTCCACATG CCCATGATCC TACACCAAGC AAAGCAGGAG CTGCCCCTCC
     6401 TCATAAACCC ATAAGTCCTC CTCTTGAGCA AAGTAGCTGG GAAGGCAGAA
     6451 GTTATTCAAG CTCCCCTCTG CCCCAGTTTC AAAGACAGAC TCAGCTCAAG
     6501 CCCACATGCA GCAAACCCTA TAAAAGTCTC ACCTCTTGGC ATTTCTGCCA
     6551 TGGTAATGCT TTCTGCTCTC ACTAATGAGG ACTTCTCCTC AGCTCCTGGG
    Exon R5
     6601 ACCTCCACAG TGGATGTGGG AACCTCAGGG ACTCCATCCT CCAGCCCCAG
     6651 CCCCACGAGT AAGTACCAGT CAATGGCATC TCTATTAGAG CATGCTATCT
     6701 CTGTCATTTT TACTCAGATG AAGATGGAAA ATCATAGCAA ATCTACTGAT
     6751 AGTGAGTGGA CCAACGAAAT TTGTTGGCCA CCTAGTGTGT ACCAGATCCT
     6801 AGAGATACAG GAGGGAAAAC AAAACCAATA CAAAATTTCT GCTCTCAGTG
     6851 AGCTTGTATT CTTGTCATGA TGATGATGTT GGTGGTGGTG CTGTTGATGA
     6901 CGATGATGAT GATGATGATG ATGATGATGC TGGTGATACT GTTGATGGTG
     6951 ATAGTGATGT TGATGACAAT GATGATGATG ATGATGTTGA AGAAAATGAT
     7001 GCTGGTGATG GTGGTGGGGG TTATTATGGT AATAATGATA TGTTGAGTGT
     7051 GACGATGATG GTGGTGGTGT TGATGATGAT GATGATTATT ATGCTAGTGA
     7101 CATTGATGAT GGTAATGGTG ATATCAACGA CAGTGACAAT GATGGTGATG
     7151 AGGATGATGT CGGTGATGGT GGTGGGGTTA TGATGGTAAT GATATGTTGA
     7201 ATGTGATGAT GGTGATGATG ATATTTGTGG TTCATGATGG GGATTGTCAT
     7251 GGTGGTGCTG GTGGTACTTG TGATGACAAT AATGATAATA ATGATGACAA
     7301 TGATAGTGAT GATGGTGATG GTGATAATAA AGATAACAGA TATCACCTTA
     7351 CAATATTGAG CACTAAATAT GTACCAAGAG CTATGCTCAG TATCTAACTA
     7401 CTATTATATA ATCTACTTTA GAAAATGAAT TGTATCATAG ATAAGAAAGG
     7451 CGTGGAAAAT ATTTATTATG TCACTCAATT TAATTGCTGC ATATGGTTAT
     7501 TACAAAGTGC TATTCTCTCT ACTTTGAACA TAATGTTTAT TTCACACTCC
    Exon R1
     7551 CACTATAGCT GCTGGCCCTC TCCTGATGCC GTTCACCCTC AACTTCACCA
     7601 TCACCAACCT GCAGTACGAG GAGGACATGC GTCGCACTGG CTCCAGGAAG
     7651 TTCAACACCA TGGAGAGTGT CCTGCAGGGT CTGGTTAGTG TCCTGCCCTC
     7701 CACACTCTGC CCTGCTCATG ATACCCAGTC CCTCTTACAT CATCCATGCC
     7751 AGGGCAATGG AAGAATATCA AACCCAACTC ACTTTTGCCC CAAGAGATGC
     7801 AAGCCTCAGC CAGGAGCGGT GGCTCACGCC TGTAATACCA GCATTTGGGA
     7851 GGCCAAGGCG GGTGGATCAC CTGAGGTCAG GAGTTTGTGA CCAGCCTGGC
     7901 CAACATAGTG AAACCTCATC CCTACTAAAA TACAAAAATT AGCCAAGCAT
     7951 GGTGGTGCAT GCCTGTAATC CCAGCTACTT GGGAGGGTGA GGCAAGAGAA
     8001 TCACTTGAAT CAAGGAGGCA GAGGTTGCAG TGAGTCAAGA TCATGCCACT
     8051 TTACTCCAGC CTAGGCAAAA AAGCGAAACT CCATCTCACA AAAAAAAGAA
     8101 AAAAAGAGAG AGATGCAAGC CTCCCCCACC AAGGCCAGCC CTGCCCACCT
     8151 CACTTCTGCC TGGCTCTTAC ATAAAACTTA GCCCTCCTAC TCACTGCCCT
    Exon R2
     8201 CTCCCTCCTC CACAGCTCAA GCCCTTGTTC AAGAACACCA GTGTTGGCCC
     8251 TCTGTACTCT GGCTGCAGAT TGACCTTGCT CAGGTGAGAA CTTAGAATTT
     8301 CCAGCCTGGC TGCCCCACTT GTACTCACTC CAAAAGACTT TGCACTGCTT
     8351 CCTTGCTGCA CTTCCTAGGG ATATCCTCAC CAAAGGTGGA ATTCAGGAGT
     8401 CACAGGCTTC AGGATCAGTG TGTTTCCTGA CAGTAACACC CCTACACTCC
     8451 ACCTCAACAG AGAGAATCTG CATGGCCCAT CATCAGGATT GAGCCTCTCC
     8501 CTTTATCATC CCTCTGAATT CCCTCCATTC CCTGTGCCTC CCTTTCCTTT
     8551 ACATGTTAAA TTCTGTCCCC AGGATTTCTT TCAGGACAAT CATGCCTTAT
     8601 CCACGTGATT TCATCCTCAT TTCGAGCTCT TCACTGGGCT CAAGTCCGGC
     8651 TCCCCGTCCC GTCCATGAAA GTGTCAGTTT CATCTTGTCA CTGTATCCGT
     8701 GACTCCACTC ACAGTCCTCA GCAAGCCAAT AGTCCATGCA CTAAGAGTCG
     8751 ATGTGGCTTC TCACCTCTTT CCCAGGTTTC TCATTTCTCT GGTCCTTGCT
     8801 GTCCTTCCCT CAGCAATCGC AAGACCCTTC CTAGATAAAC TTTTCATTGT
    Exon R3
     8851 GATTTTTCCC ACTGACCCTC CCCAGGCCCG AGAAAGATGG GGCAGCCACT
     8901 GGAGTGGATG CCATCTGCAC CCACCGCCTT GACCCCAAAA GCCCTGGACT
     8951 CAACAGGGAG CAGCTGTACT GGGAGCTAAG CAAACTGACC AATGACATTG
     9001 AAGAGCTGGG CCCCTACACC CTGGACAGGA ACAGTCTCTA TGTCAATGGT
     9051 GAGTGGCTGT GATGTGGTTG AAATCTCTTC CCCCTTGCTG GGCAGCCTCT
     9101 AATCTCTAAC TAGAGATCAC ACTCCCTGCC TGGCCTTTGA AAATTCTGTC
     9151 ATGTGCTCTA CATGGGATGA CTAAGGTCTG GACTTCATGG TTTCCTTACC
     9201 ATCATGGACT GTGTTCCCTC AGGGCATTCT TTCCTGATGT GAGGATGCTG
     9251 ATAGAAAATC TTCAATTGTC CCTGTACCAT GAAACTCGGT TCATTGCACC
     9301 AGGGTAGCAT TGACCTCCAT TTGGTCCCCC ACCTCTCCTT GTCTCTTACC
    Exon R4
     9351 CACTCTCCTC CCTCCTTCTC TATGCAGGTT TCACCCATCA GAGCTCTGTG
     9401 TCCACCACCA GCAGTGAGTA TTCAACTCAT ATCCACATGC CTCGGTTCCT
     9451 ACACCAAGAG GAGCAGGAGC TGGCCCCTCC TCATAAACCC ATTAAGTCCT
     9501 CTTCATAAGC AAAGGATTTA GGAGGGCAGA AGTTATTTAA GTGTCCCTCT
     9551 GCCCAGCTCA AGAGACCGAC CCAGCTCAAG CTACACATGC AACAAACCCC
     9601 ATAAATAGTC TCCCCTCTTG CCATTTCTGC CAAGAGAGTG CTTTATGCTT
    Exon R5
     9651 TCACTGATGA GAACTTTTCC TCAGCTCCTG GGACCTCCAC AGTGGATCTC
     9701 AGAACCTCAG GGACTCCATC CTCCCTCTCC AGCCCCACAA GTAAGTATCA
     9751 GTCAATGACA TCTCTATGAG AGCATACCTG ATTAGTGTAA ACATCTCTGT
     9801 CATTTTCACT CAAATAAAGA TGGAAAATCA TAGTAAATCT AGTGATACTG
     9851 AGTGGACAAA TTTGTTTGTT TGTTTTTTCT CATCCTTTTC ACTTTTTTTA
     9901 TTATACTTTA AGTTTTAGGG TACATGTGCA CAATGTGCAG TTTAGTTACA
     9951 CATGTATACA TGTGCCATGC TGGTGTGCTG CACCCATTTG CTCGTCATTT
    10001 AGCATTAAGT ATATGTCCTA TGCGATCCAA GCCCACGCGC CGCACCACGT
    10051 GCAACAGTTT CACAGATTGG ATGGTCCGAT ANNNNNNNNN NNNNNNNNNN
    10101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    10151 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R1
    10201 CTTCACCATC ACCAACCTGC AGTATGAGGA GGACATGCAT CGCCCTGGAT
    10251 CTAGGAAGTT CAACACCACA GAGAGGGTCC TGCAGGGTCT GGTTAGCACC
    10301 CTGCCCTCTT CACTCTCCCC CGCCCTGGAT GCCGAGCCCC TCATACAACA
    10351 TTCATGCCAG GGCAATGGAA GAATATCGCA CCAACCTTGC CCTCATCCCC
    10401 AGAGATGCAA GCCTCACCCA CTGAGGCCAG CCACTCTCAT GGGTGTCTGC
    10451 CCCACCCACC TCACTTTTGT CCCCACACAG GGACCTTAGC CCTCCTACTT
    Exon R2
    10501 ACCTCTCTCT CCCTCCCCCA CAGCTTAGTC CCATATTCAA GAACACCAGT
    10551 GTTGGCCCTC TGTACTCTGG CTGCAGACTG ACCTCTCTCA GGTGAGACCT
    10601 TAGAAGATCC AGCCTGGCTG CCCCAGTTGT TCCCACTCCA GTAGATTTTG
    10651 CTCTGCTTCC TTGCTGCACC TCCTAGGGAT ATCCTCACCA AAAGGGGAAT
    10701 TCAGGAGTCA CTGGCTTCTG GACCAATGTG TTTCCTGATA GTAACACTCC
    10751 CACACCTCAC CTCAACAGGG AGAATCTGCA TGGTCCATCA TCAGGATTGA
    10801 GCCTCTATCC TGATCATCCC TCAGAATTCC CTGCCCCTCC CTTTCATTTA
    10851 GGTGTTAAAT TCTGTCCCCA GAATTTCTCT CAAGACAATC ATGCCTCATC
    10901 CAAGTGCTTT CATCCCTGTT TCTAGCTCTT CACTGGTCTC AAGTCTGGGC
    10951 TCTCCTGTCC CCATGCTATG AGAATGCAGG TTTCACCTTG CACTTTTATA
    11001 AGCATGGTTG TATCTGTGAC TCTGTGCACA GTCCCAAGCA AGCCAGTAGT
    11051 CCATGCACTC AGAGAATCTA AGTGTAGCTT CTCACCTCTT TCCCAGGTTT
    11101 CTCATTTCCT CTGGTTCTTT ACTGTCTTTC CATCAGCAGT CTCAGGACAC
    Exon R3
    11151 AACCTAAGTA ATCTTTTCAT AGTCATTCTC CCCACCTACC TTCCCCAGGT
    11201 CTGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CATCCATCAT
    11251 CTTGACCCCA AAAGCCCTGG ACTCAACAGA GAGCGGCTGT ACTGGGAGCT
    11301 GAGCCGACTG ACCAATGGCA TCAAAGAGCT GGGCCCCTAC ACCCTGGACA
    11351 GGAACAGTCT CTATGTCAAT GGTGAGCAGC TGTGATGTGG TTGGAGTCTT
    11401 TTCCTTCTAG AGTCTGGAAA GAATCTAATC TGTGGCTTGA AGTCACACTC
    11451 CCTGCCTGGC CATTGAATAT TCTGTCATGT GGTGTAGATG GGATGACAAA
    11501 GTTCTGGACT TCACAGTTTC TTCATTGTCG TGAACTGTGT TCCCTCAGGG
    11551 CACTCTTCCC TGTTGTGAGG ATACTGATAG GAATTCTTTA ATGGCCCCAG
    11601 TCCCATGAAA CTCATTGTCC CATGAAACTC ATTTAATTGC ATTGGGATTG
    11651 CCATGACCTT ATTGTGTCCC TCGTATCTCC TTAACGCTTA CCAAGTCTCC
    Exon R4
    11701 TCCCTCCTTC TCTATGCAGG TTTCACCCAT CGGACCTCTG TGCCCACCAC
    11751 CAGCAGTGAG TATTCAACTC ATGTCCACAT GCCCCTGATC CTACATTAAG
    11801 TGGAGCAGGA GCTGGCCCCT CCTCTTAAAC CCATAAGTCC TCCTCTTGAG
    11851 CAAAGGAGCT GGGAAGGCAG AAGTTATTGA AGCTCCCTTC CACCTAGCTC
    11901 CAAAGACAGG CCCAGCTCAT GCCCGTATGC AGCAGACCTC ATAATAGTCT
    11951 ACCTTCTTGC CATTTCTGCC ATGAGATTAT TTTCTGCTTT CACTGATGAG
    Exon R5
    12001 CACTTTTTCT CAGCTCCTGG GACCTCCACA GTGGACNNNN NNNNNNNNNN
    12051 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    12101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R1
    12151 ATTTTCAATT CCCACTACAG CTGCTGGCCC TCTCCTGGTG CTGTTCACCC
    12201 TCAACTTCAC CATCACCAAC CTGAAGTATG AGGAGGACAT GCATCGCCCT
    12251 GGCTCCAGGA AGTTCAACAC CACTGAGAGG GTCCTGCAGA CTCTGGTTAG
    12301 TGCCCTTCCC TCCTCACTCT GCCCAGCCCC AGATATCCAG TCCCTTCTAC
    12351 ATCATCCATG CCAGGGTGAT GAAAGAAGAT AGCAACAACT TCCCCCCTTC
    12401 CCCCCAAGAG ATGCAAGCCC CACCCACAGA GACCAGTCCT GCTTATTGGT
    12451 GCCTGCTCCA CCCACCTCAC ATCTGCCCCG ACACACACAC ACCTTAGCCC
    Exon R2
    12501 CACTACTCAC CTCCCTCTCC CTCCTCTACA GCTTGGTCCT ATGTTCAAGA
    12551 ACACCAGTGT TGGCCTTCTG TACTCTGGCT GCAGACTGAC CTTGCTCAGG
    12601 TGAGACTTTA GAAGAGCCAG CCTGGGTGCC CAAACTTGTT CCCACTCTAA
    12651 AAGACTTTGC ACTGCTTCCT TGCTGCACTT CCTAGGTATA TCTTCACCAC
    12701 AAGGGGAATT CAGGAGTCAT TGGCTTGAGA ACCAGTTGTT TCCTGATAGT
    12751 AACACCCCCA TGCCCCAACT CAACATGCAA AATCTTCATG GTTCATCATC
    12801 AGGATTGAGA CACTACCCTG ATTACCCATC TGAATTCCCT CCTTTCCCTG
    12851 ACCCCTCCCT TTCATTTAGG TGTTAAATTC TGTCCCCAGG ATTTCTCTCA
    12901 AGATAACCAT GCCTCATCCA CATACATGCA TCCGCCTTTC AAGCTCATCA
    12951 CTAGTCTGAA GCTCTGGGTT CTCCTGTTCC CATGCCATGA GAATGCAGGT
    13001 TTCACCTTGC ACTTTTATAA AAATTATTAT ATCCATGACT CTGCTTGCAG
    13051 TCCCAGACCA AGATAGTGGT CTATGTACTC AGATAATCTA AGTGCAGATT
    13101 CTCACCTCTT TCCCAGATTT CTCATTTCCT CTGGTTCCTT GATATGTTTC
    13151 CCTCAGCAAT CTCAAGACAA GTCCTAGGCA ATCTTTTCAT TGTCATTCCC
    Exon R3
    13201 CCTCCTACCT TCCTCAGGTC CGAGAAGGAT GGAGCAGCCA CTGGAGTGGA
    13251 TGCCATCTGC ACCCACCGTC TTGACCCCAA AAGCCCTGGA GTGGACAGGG
    13301 AGCAGCTATA CTGGGAGCTG AGCCAGCTGA CCAATGGCAT CAAAGAGCTG
    13351 GGCCCCTACA CCCTGGACAG GAACAGTCTC TATGTCAATG GTGAGCAGCT
    13401 GTGATATGGT AGGGGTCTCT TCCTCCTGGC TGTGCAACCA TCTAATCTCT
    13451 GGCTTGGGGG CACACTCCCT GCCTGGCCAT TGAAAATTCT GTCACGTGCT
    13501 CTACATGGGA TGACTAAGTT CTGGACTTCA TGGTTTCTTT GTTATCATGA
    13551 GAGGCATTCC CTCTGGGCAC TCTTCCCTGT TGTGAGGATG CTGATAGGAA
    13601 ATCTTTAATG ACCCCTGTCC CATGAAACTC ATTTAATTGC ACCAGGGTAG
    13651 TCCTGAACTC TATCGCGTCC CCCACATCTC CTTAACCCTT ACCCAGTCTC
    Exon R4
    13701 CTCCCTCCTT CTCTATGCAG GTTTCACCCA TTGGATCCCT GTGCCCACCA
    13751 GCAGCAGTGA GTATTCAACT CATGTCCATG ATGCCCCTGA TCCTACATCA
    13801 AGTGGAGCAA GAGCTGGCCC CTCCTCTTTA ACCCATAAGT CCTCCTCTTG
    13851 AGCAAATGAG CTGGGAAGGC AGAAGTTACT CAAGCTCCCC TCTGCCCCAG
    13901 CTCCAAAGAC AGACCCAGCT CAAGCCCACA TGCAGCAGAC CTCATAATAG
    13951 TCTATCTTCT TGCCATTTCT GCCATGAGAG TGCTTTCTGC TTTCACTGAT
    Exon R5
    14001 GAGGACTTTT TTCAGCTCCT GGGACCTCCA CAGTGGACCT TGGGTCAGGG
    14051 ACTCCATCCT CCCTCCCCAG CCCCACAAGT AAGTACCAGC CAATGGTATC
    14101 TGTATTAGAT CATGCCTGAT GAATGCAAAC ATCTGTGCCA TTTTCAGTCA
    14151 AATGAAAATG GAAAATCATA ATAAATCTAG TGATACTGAG TGAACCAAAA
    14201 AAAATGTATT GGCCACCTAC AGTGTACCAG ACCCTAGGGA TATAGCAAGG
    14251 AAAATAGAAC CAATAAAAAC ATCTCTGCCC TCAGTGAGCT TGTGTTCATG
    14301 TGATGATATG ATGGTGGTGG TGGTGGTAAT AGTAATAATG ACATATTCAG
    14351 TTTGATGATA ATTTATGATT ATGGTGTTGC TGTTGATGAT GGTGGTGGTG
    14401 ATGTTACTGA CAATGATGGT GACGGATCTT TGAGGATATT GTCCGTGATG
    14451 GTCGTGAAGA TTATGATGAT AATGATGATG TGTTAAGTGT GATGATGATG
    14501 ATGATCTGTG GTGATGCTGT TTAGGATGCT GTTCCGTGGT ACCGATGATA
    14551 TTGATGTTGG TCGTGGTTAT GTTGTATGAC AATGACAATG ATGGTGATGA
    14601 GGATAATCGC CAGTGATGGT GTGGGTTTAT GATGATGATG ATGTGTTGAA
    14651 TGTGGTGATG ATAATGTTCG TGGTGGTCGT GATGGGCATT ACTATGGCAG
    14701 TGATGGTCAT AATAATGATG GTGATGGTGA CAATGATAGC AAGGATGATG
    14751 ATGGCAATAA AGATAGTACA TAACATCAGA CAATATTGAG CTCTGAATAT
    14801 GCACCACGAG GAGTGCTCAG CATCTAAATA CTATTATATA ATATATTTTT
    14851 GTAAAAATAA ATTGTATTGT TTTAGGCAAG GGAAGCATGG TAAATATTTT
    14901 GTCACTCAAT TTAAATTCTG CATATGTTTA AAGATAAGTC TATTGCAAAC
    14951 TCCTATTTTC TCTACTTTGG ACATAGTGTT TGTTTCCCAC CTCCACTACA
    Exon R1
    15001 GCTGCTGGCC CTCTCCTGGT GCCATTCACC CTCAACTTCA CCATCACCAA
    15051 CCTGCAGTAC GAGGAGGACA TGCATCACCC AGGCTCCAGG AAGTTCAACA
    15101 CCACGGAGCG GGTCCTGCAG GGTCTGGTTA GTGCTCCACC CTCCTCACTC
    15151 CGCCCCACCC CAGAGAGTCA GTACCTCCTA CATCATCCAT GCCAGGTGAT
    15201 GGAACAAGAT CATACCCACC TCACCCTTGC CCCAAGAGAT GCAAGCCATG
    15251 CCCATTGAAA CCAGCCCCAC TCACTGATGC CTGTTACTGC CCCACCTGAC
    15301 TTCTGCCCTA CACACCCACA CACGCAACTT AGCCCTCCTA CTCATCTCCT
    Exon R2
    15351 TCTCCCTCCT CCACAGCTTG GTCCCATGTT CAAGAACACC AGTGTCGGCC
    15401 TTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGGTGAGA CCTTAGAAGA
    15451 TCAAGCTTGG CTGCCCCACT TGTTNNNNNN NNNNNNNNNN NNNNNNNNNN
    15501 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    15551 NNNNNNNNNN NNNNNMNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R1
    15601 NGTGTTAGTC TACTTTTGAA CACTGTTTAT TTCCCATCTT CACTATAGCC
    15651 GCCAGCCCTC TCCTGGTGCT ATTCACAATT AACTTCACCA TCACTAACCT
    15701 GCGGTATGAG GAGAACATGC ATCAGCCTGG CTCTAGAAAG TTTAACACCA
    15751 CGGAGAGAGT CCTTCAGGGT CTGGTAAGAG CCCCACATAC CTCATTCTAC
    15801 CGCCACTCAC CATGTTTAGT CCTGCCCACC TCACCTATTG CAGAGCATGG
    15851 AAGATCTCAT CTACCTCATC TTGCCCCCAG ATATGCATAC CCCAACCACT
    15901 GATGCCAGCC CCACCAACTG TTGCCAGCCC TGCCCACCTC CCTTCTACCA
    15951 CACCCCTATG ACTTCAGTCC TCCCACTCAC CTCCCTCTCC CTCCTCCACA
    Exon R2
    16001 GCTCAGGCCT GTGTTCAAGA ACACCAGTGT TGGCCCTCTG TACTCTGGCT
    16051 GCAGACTGAC CTTGCTCAGG TGAGAACTGA GAACAGCCAG TCTGACTGAT
    16101 CTGAGCAGTT TGACCTGCTT CCCTTCTGCA CTCCCTGGAG ATGTCCGCAG
    16151 CCAGGTGGAA TCCAGGAGGC AGTGGCTCTA AGACCAATGT GCTTCCTGTT
    16201 CCCACCACCT CCCACCTCAA CTGAGAGATG CAGAGCCCAT CAGCAGGACT
    16251 GAGCTTCTAC CTTGGTCATC CCTCTGAATT CCCTCCTTTC CCCTACCTGC
    16301 CTTTCCACAA GTGGTTCAAT TCTGTTCCCA GGATTTCTCC CAAGAAAAAC
    16351 ATGCCTCGTC CACTTGCTTT CATCCCCAAA CCTAGCTCTT CACCTGTCTC
    16401 AAGTATGAGT TCTCCTTACC CCATGCTACA AGAATGCAGT TTCCACTTTG
    16451 CAATTTTATA AAAATCCTTG CATCCATGAT TCTGCTCATA GTTGCTAAGA
    16501 GTCAGTGCAC TCAGAGAATG GAAGTATGGC TTCTCACTTC TCTACCAGGC
    16551 TTCTCATTTC CTCTGGCCCC CTCCTGTCCT GCCCTGTGGG ATCTCAGAAC
    16601 CCCTCCCTAG GCAATCCGTG TATTGTCTTT CCCCAATCTT GCCCTCCCCA
    Exon R3
    16651 GGCCCAAGAA GGATGGGGCA GCCACCAAAG TGGATGCCAT CTGCACTTAC
    16701 CGCCCTGATC CCAAAAGCCC TGGACTGGAC AGAGAGCAGC TATACTGGGA
    16751 GCTGAGCCAG CTGACCCACA GCATCACTGA GCTGGGCCCC TACACACTGG
    16801 ACAGGGACAG TCTCTATGTC AATGGTGAGT AGTTGTGATG TGGTTGGAGT
    16851 CTCTTCCTCC TTGCTGGGCA GCCTCTACTC TCTGCCTTGA GGTCACGCTC
    16901 CCTGCCTGGC TATTGAATGC TCATCCATGT TGTCTGTATG TGATGGCTGA
    16951 GGTTGGAACT TCATGGTTTC TATTTCATCT TGGACTGAGT TCATCCTCAG
    17001 GATCTGCTTT CTGGATCTGA GGGTGCTGAT AGAGAATCTT CAATGGTTCG
    17051 TGTTCTGGGA AATTCCTTCC ATTGCACCAG GGTACCCTGA CCCCTATATA
    17101 GTTCCCCACC ACTCCCTTAA CCCTTACCCA CCCTCTTCCC TCCCTCTCTA
    Exon R4
    17151 TGCAGGTTTC ACACAGCGGA GCTCTGTGCC CACCACTAGC AGTGAGTATC
    17201 CACTGATTTC CAGTGCTCCT GATCCTACAT CATGCAGGGC AAGAACTGAC
    17251 CCCTCCTCAC ATGCCCCTAT GTCCTCTATG AGCAAAGGAG CTGGGACAGC
    17301 ACAAGTTACT CCCTTTCCCT TCTGGCCCAA GTCTCTTCAG AGAGAGACCC
    17351 AGCTCAAGCC CCACATGCAG CAAGGTCCAT AAATACTCCT ACCTGCTGGC
    17401 ATTTCTGCCA TGAGAGGGTT CAACACTTTC ACTAATGAGG CCTTCTCCTC
    Exon R5
    17451 AGTTCCTGGG ACCCCCACAG TGGACCTGGG AACATCTGGG ACTCCAGTTT
    17501 CTAAACCTGG TCCCTCGGGT AAGTACAAAT CAATCGCATC TCTGTTAGAG
    17551 CATGCCTGAT GACTGTCAAC ATCTCTGCCA TTTTCACTTA AATAAAGATA
    17601 AAAAATCCTA GTGAATCTAC GGATGAGGAG TCATCCAGCA AACTTAATTG
    17651 AGTGCCTAGT TTCTGCAGGG CTCTAGGGAT AAGAAAGGGG ACACAAAACA
    17701 GTTAAAAATA TCTGCTGCAA GAAAGCTTAT TTTATTGTGA GGGTGATGGG
    17751 AGTTGGTGGT GGTGAAGTTA CTGGAGATGA TGACAATAAG AATGGTGATG
    17801 CTAGTGATGA TGATGGTGAT AAGGATGATA ATTATGAAGA TGGTGGTGGT
    17851 GATGATGATG ATGGTNNNNN NNNNNNNNNN NNNNNNNNHN NNNNNNNNNN
    17901 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    17951 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18001 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN nNNNNNNNNN NNNNNNNNNN
    18051 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18151 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18251 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18301 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18351 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R1
    18501 MNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NGCTGCCAGC CCTCTCCTGG
    18551 TGCTATTCAC TCTCAACTTC ACCATCACCA ACCTGCGGTA TGAGGAGAAC
    18601 ATGCAGCACC CTGGCTCCAG GAAGTTCAAC ACCACGGAGA GGGTCCTTCA
    18651 GGGCCTGNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18701 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18751 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    18801 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R2
    18851 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNCTC AGGTCCCTGT
    18901 TCAAGAGCAC CAGTGTTGGC CCTCTGTACT CTGGCTGCAG ACTGACTTTG
    18951 CTCAGGNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNAGAAT
    19001 TCAGTCGACC TACCGGCTTT GATGATTGCT CAGTTGAACT TAGAAATGCA
    19051 CTGTCTGCCC AATGGTCCAG TCTCATGAGT GTGACTCTTT TCTGCCTCTC
    19101 TTGGGTATCT GATCAAGATG GACTCAGGAA AAGTGCTCCA GATATCTGTC
    19151 TCCAATATAA CACTGCCCCT GCCATCACAC CCAAATGACT GGAAGTTTCA
    19201 CAGGGTCATC AGCAGGGATT GGACTTCCAC CCCGGCCATC CCTCTGAATT
    19251 TTCCCTCTTT TCTCCCCACC TCCCTTGCCC TTAGGTGTTA AAATTCTCTA
    19301 ACTAAGATTT CTCTCAAGAC AAATGTGCCT CATTCACTTG TTTAATTCCC
    19351 AATTCCAGCT TGTCACCTGT CTCAAGTCTA GGCTGTCCTG TCCCCATGCC
    19401 ATGAGAATGC AAGAACCACA CTGAAATGTT AGAAAAATTC TTTTATCCAC
    19451 AAGTATGCTC ACCGTCCCAA GCTGGACAGT AGTCAGTGCA CTCAGAGAAT
    19501 CTAAGTGTGG CTTCTCATCT GTGTACCAGG CTTCTCATTT CCTGTGGGCC
    19551 CTTCTTGTCC TTCCCTCCGC AATCTTGGGA CTCCTCCCTA GACAAAACTT
    Exon R3
    19601 TATTATTATT CCCCTCACCT GCCCTCTCCA GGCCTGAAAA GGATGGGACA
    19651 GCCACTGGAG TGGATGCCAT CTGCACCCAC CACCCTGACC CCAAAAGCCC
    19701 TAGGCTGGAC AGAGAGCAGC TGTATTGGGA GCTGAGCCAG CTGACCCACA
    19751 ATATCACTGA GCTGGGCCCC TATGCCCTGG ACAACGACAG CCTCTTTGTC
    19801 AATGGTGAGC AATTGTGATG TGGTTGGAGT TTCTTCTTCC TTGCTGAGCA
    19851 GGCCTCTACT CTCTGTCTTG AGGTCACTCT CCCTGCCTGG CCACTGGTCT
    19901 TGGCCATGTT GTCTGTATTT GATGATTGAT ATGAACTTCA CCGTTTCTTC
    19951 TTCATCTTGT ACTGGAGACC TTCATCCTCA GGACCTTCTT CCCTGATCTG
    20001 AGTGTACTTG TATAGAATCC TCAAAGCCCA TGTTCCCTGA AACTCCTTCA
    20051 ATTGCACCAT GGTAGCACTG ACCCCTTTTG GTCCCCCACC TTNNNNNNNN
    Exon R4
    20101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN TTCACTCATC
    20151 GGAGCTCTGT GTCCACCACC AGCACTNNNN NNNNNNNNNN NNNNNNNNNN
    20201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    20251 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    20301 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    Exon R5
    20351 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNCCTG GGACCCCCAC
    20401 AGTGTATCTG GGAGCATCTA AGACTCCAGC CTCGATATTT GGCCCTTCAN
    20451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNGACTCCA GCCTCGATAT
    20501 TTGGCCCTTC AGGTAAGTAC CAGTCAATGG CACCTCTATT AGAGTATGCA
    20551 TGATGAGTGT CAACATCTCT GTCCTTTTCA CTCAAATAAG ATTAAAAATC
    20601 ATAGCAAATT GTACGTGATG ATGAGTCACC CAACAAACTT CTTTGAGTAC
    20651 CCACTCTCTG CCAGGCCCTA GAGATAAGGC AGGGAACACA AAAGAGGTAA
    20701 AAATCTCTGC CCTCAGAGAG CTTCTTTTAT TTTGAGGATG ATGTGGGATA
    20751 GTGGTGATGA TGATGTTGCT GGAGATGATT ACAATAATGA TGGTGATGCT
    20801 TATGACCATG ATGTGATGAT GATGGTGATT ATGAAGATGA TGATGATGAT
    20851 ATTGATGATG GTAGTGGTTT TGACAGTAAT GATGATGTGA TGATGATGAT
    20901 GATAGTGGTG GTGGTGATTA TGGGAAGGAT GACAGTGGTG GTGGTGATGG
    20951 TGGTGGTTGT GGTGGTGATT GACAATGTGG TGGTGATATT GACAATGAGG
    21001 ATGATGATGA TAGTGGTGGT GGTTATGATG GTTAAGGATG ATGTGATGAT
    21051 GGTGTTGGTG ATCACGGTAC TAGTGGTGGT GATGTGGACC GTCATGGTTG
    21101 TGGTTGTGGT GGTGATGGTG GTGATCATGA TGATAATGAG GATGATGGTG
    21151 GTGATTGTCA TGATGGTAAG GATGAAACAG TGATGGTGTT GGTGACCATG
    21201 TTCCTGGTGG TGATGGTGCA GGTGATGATG TGGATGATGA TGGTGATGGT
    21251 GGTGGAGATG ATAGGGATTA TGAATATGGT TCGGGTCTCT GACTGGTGGT
    21301 GGTGATGACA ATAATGAAAA TGATGGTCAC AGTGTTGGTG ATGATGATGG
    21351 TGGTGATAAC AAAGGTAATA GATAGTGTCT AGTATTATGG AACACAGAAC
    21401 ATCACCAAAG GTTATGCTCA GCATCTAACT ATTATTATTT AGCATGCTCT
    21451 ATGAAAAACT TTGATCGTTA TAGTCAAGGG AGGCATGAAA ACCTTCTATT
    21501 TTATCACTCT CTTTAAATCT GGTTGCATAT GTTTAGAAAT AAATCTATTA
    21551 CAAACTCTTA AATGTTCTCT ACTTTTGAAC ATAGTGTTTA TTTCCCACCT
    Exon R1
    21601 CCACTACAGC TGCCAGCCAT CTCCTGATAC TATTCACCCT CAACTTCACC
    21651 ATCACTAACC TGCGGTATGA GGAGAACATG TGGCCTGGCT CCAGGAAGTT
    21701 CAACACTACA GAGAGGGTCC TTCAGGGCCT GGTGAGAGCC CTGCCCACCT
    21751 CACTCTGCCC TGCCCACCTT GTCTTGTTCC ACCTACGTCA CCCATTCCAA
    21801 GGCATGGAAG AAGATCTCAC CCACCTCCCC TCACCTGAGA GATAGCCCCG
    21851 CCCCCTGATT ACAGCCCCTT CCACCTTACA TCTTCCTCAC TTCTATGTCC
    Exon R2
    21901 TCAGCCATCT TACTCACCTC CCTCTTCCTC CTCCACAGGC TAAGGCCCTT
    21951 GTTCAAGAAC ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC AGGCTGACCT
    22001 TGCTCAGGTG AGAACTGAGA ATAACCAGTC TGGCTACCCC AAGTGTTCCC
    22051 AGGCCCAAGG AGTTTCATCA GCTTTCTTCC TTCCCTCCCT ATGGAAGTCC
    22101 TCAGCACAAG TGGAATTCAG GCGTTGGTGG CTCCAGGATG AACATATCTG
    22151 CTGATCCTAC CACCTCCCCC ATCAATCGAG AGAATTTGCA GGGCCCATCA
    22201 GCCAGATCAG GCTTCTACTT TGGTCATCCT TCTGAATTTC TTACTTCTCC
    22251 CTACCTCCCT CTCCTTCAGG TGTTAAATTC TCTTCCAAGG TTTCTCTCAA
    22301 GATAAACATC CCCCATCCAC TTGCTTTCAT CCCCAATTCC AGCTCTTAAT
    22351 ATTTCTCAAG TCTGGGCTCT CCTGTCCCCA TACCATGAGA ATGCAATTTT
    22401 ATAAAATTCT TGTATTCCTG ACTCTACTCA CATTCCCAGG CTGCCTGGAA
    22451 GTTGGTGCAT TCAGAGAATC TTAGTATGGC TTCTCACCTG TCTACCAGGA
    22501 TTCTCATTTC CTCTGTCCCC TTCCTGTCCT GCCCCCAGGA ATCTCAGGAT
    22551 GCCTCCCCAT AGGCAATCTA TTTAATGTCA TCCCCCTTAT CTGCCCTCCC
    Exon R3
    22601 TAGGCCAGAG AAAGATGGGG AAGCCACCGG AGTGGATGCC ATCTGCACCC
    22651 ACCGCCCTGA CCCCACAGGC CCTGGGCTGG ACAGAGAGCA GCTGTATTTG
    22701 GAGCTGAGCC AGCTGACCCA CAGCATCACT GAGCTGGGCC CCTACACACT
    22751 GGACAGGGAC AGTCTCTATG TCAATGGTGA GCGGCTGTGA TGTGGTTGGA
    22801 GATTCTTCCT CTTTGCTGGA CAGCTTCTTA CTCTCTGACT TGAGGTCACA
    22851 CTCCCTGACT GGCCATTGAC GTCTTGGCTA TGTTGTCTGT ATGTGATGAC
    22901 TGATGTCTGA ACTTCATAGT TTCTTCATCT TGGACTGAGT TCATCCTCAG
    22951 TACCTTCTTC CCTGATCTGA GGGTACTGAT AGAGAATCTT CAAAGGCCCC
    23001 TGTTCCTTGA AACTTCTTCC ATTCCACTAG GGTATCTGTG ACCCCTATTT
    23051 GATTCCCCAC CTCTCCCTTA ACCCTTACCC ACTCTCCTCC CTCCTTCTCT
    Exon R4
    23101 GTGCAGGTTT CACCCATCGG AGCTCTGTAC CCACCACCAG CAGTGAGTAT
    23151 TCAACCGATG CTCCAGTAGC CCCAATTATA CACCAAGCAG GGCAGGAGCT
    23201 GTCCTGTCTT CCTATGCCCC TATGTCCTCT TCATAAAGGA AGGGGCTGGG
    23251 AGGGCACAAG TTATTCCCTT TCCCTTCTGG CCAGCTCCAG AGAGAGACCC
    23301 AGCTCAGGCC CGATATGCAG CAAGGCCTGT AAATAGTTTT ATTTGCTGAC
    23351 CTTTCTGCCA TGAGAGGCTT GGATGCTTCC CCTGAAGAGG GTTTCTCTGT
    23401 AGCTCTTGGG ACTACCACAG TGGACCTGGG AAACTCTGGG GATCCACCCC
    23451 TTCTACTGGT CCCTTGAATA AGTACCAGCC AATGGCACCT CTGTTAGAGC
    23501 ATGGCTGATG AGTGTAAACA TCTCTTCCAT TATTCAGTCA AATAAAGATG
    23551 GAAATTCTTT ATAAATCTAG TGATGATGAG CCAACCAACA AACTTTATTG
    23601 AGCATTGTGA CAAGCCCTGG GGCTCTGCCA AATCCTGGGG ATATGGCATG
    23651 GATCATGAAA CAATTAATAA TCTCTCCTCT CAGAGAGCTA TTTTTATGAT
    23701 GATACTGATG GTGGCAATGA TGATGATGTT GATGGTGATT ATGACCATGA
    23751 TGACAATGGT GATGGTGGTG GTGATGATGG TAATGATGAT GATGGTGATG
    23801 TTGGTAATGA TGGTGGTGAT TATGACAATA ATGATGGTGA TGGTGACAGG
    23851 GATGGTGATG ATTATGATGG TGGTGGTGAT AACAAAGTTA ATGGATAATA
    23901 TATGAACTTA TTGGCTACTG AATATGCACC AAAGTGCTAT GCTCAGTGTT
    23951 TAACTAGTAC TATTTAATAT GATTTCTAAA AAAAATCTTG AATTATTATA
    24001 GGCAGAAGAA TCATGGGAAC CTTTTATTTT GTCACTCACT TTAAGTCCTA
    24051 TTGCATATTT TTTAAGTCAA TTGCAAACAC AGTTTCTCTG CTTTGAACAT
    24101 TGTGTTTATA TCCAGTCACC CCAATAGTGC ATAAACCTGC TGATTGGAGC
    24151 AACTGTGTCT TACTCCCTTG TGCTTCCCTA GTATCTGCTT CAGGACCTTG
    24201 TACATGGTAG ATCGACAGAT TTAGATCTAC AGGAAAATAT GGATTTTCCC
    24251 AGGGAAGGAA GGAATGAAGT ATGCTTTCTT ATAATGTATG GAAACTTTCC
    24301 TCTTCTGCCT TGGTTCAACT TTAGTGTCTG CCAGAGTTTA CACTGGAAAA
    24351 CTATATGGCA TCTGCTCCAC TCCCTCATCC ATGACAGACA TCATTAATTG
    24401 ATTGCAGCAT TCATGGCAGA CATCACCAAT TGATAATAGC ATTCATTTTC
    24451 TCTCAGTTCA AAACAGCTTC AGAATGGTTA CCAAAAAAAA AAAATTCAGT
    24501 CGCTACCAAT TCAATTGGAG CTGACTCAGG ATTATGGGAC AGAATTCAAG
    24551 AGAGTTAGGT TCCTTGATGA TGTGTAGTGG CTATTTGTTT TCCGGTCCAG
    24601 GCTAATNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    24651 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    24701 CTTTGTGCGG CAAAGTTCAG GGGCCCCAAA AATTTCTGTG CCCCAATCAT
    24751 GGCGGACCTA GGTTTAGGCA CAAATTCCAG GGATTAAGTC CCTGGAGATG
    24801 TTATGGCTTT TGGTTTTCCT AGAAAGGCTC AGCTCAGGCT CAGCTTGGTC
    24851 ATGCTGATAT CCTTTCTTCC ACTTGGTCGA TTTGGCTGTT GATACTTATG
    24901 TATGCTTCAC GAAGTTTTTG TGCTGTGTTT TTCAGCTCCA TCGGTTGGTT
    24951 TATGTTCCTC TCTAAACTGG TTATTCTAGT TAGCAATTCC TTTAACCTTT
    25001 CATCAAGGTG CTTAGCTTTG CATTGCATTA GAACATGCTC CTTTAGCTCA
    25051 TCGTACTTTT TTATTGCCCA TCTTCTGAAG CCTACTTCTG TCAATTCATC
    25101 CATCTGATCC TCCATCCAGT TCTGCACCCT TAATGGAGAG ATGTTGCGGT
    25151 CATTTGGAGG APAAGAGGCA CTCTGGCCTT TTGGGTTTTC AGCATTTTTT
    25201 TGTTGATTAT TTCCCATCTT CAGGAGTTTT AGTTTCAGGC TTTGAGGCTG
    25251 CTGATCCTTG GATGGGGTTT TTATGGGGGT CTTTTGGTTG TTGTTGTTGA
    25301 TGATGATGAT GTTATTGTCA CTTTCTGCTT GTTTTTCTTT CAATAGTCAG
    25351 GTCCCTCTTC TGTAGGGCTG CTGCAGTTTG CTAGGGGTTC ACTTCAGGCC
    25401 CTATTCATCT GATTCGCTCC CATGTCTGGA GGTGTCACTC AAGGAGGCTT
    25451 GGAGAGCAGC GAACATAGGT GCCTGCTTCT TCTGGGACCT CTGACCTCGA
    25501 GGGACACCAA CCTGATGCCA GTAGGATCGC TCCTGTGTAG GGTGTCTGAC
    25551 AACTATTGTT GGAGGGTTTC GCCCAGTTGA CTGGCATGGA GAGCAGGACC
    25601 CATTTAATGA AGCACTTTGT CCCCTGGTGG AGAGGGGGTT CTTCACTGGG
    25651 GGGAAACCAC ATGTCTGGGC TGCTTGGATT CCTCAGAACT ACCAGAGGAG
    25701 AGGCTAAGTC TGCTGGTCCA CAGAGACTAC AGCCATCCCT CCCACTAGGG
    25751 GCCCAAGCCC AGGGAGTCCA AATTCTGTCT CTGAGCCTCT GGCTGGAGTC
    25801 TTTGGAGATC CTGCAAGGAA GCTCTGCCCA CTGAGGAAGG ATGGGTCAGG
    25851 GTTAGCCCTG AAGAGGCACT CTGGCTGCAG ACTGCCACAG CCGGTGTGTT
    25901 GGGCTGTGGG GACAAGTCTT GGGACCAAGC CGTCCAGCCT ACCCGGCTCT
    25951 AGCAGGGGAA AAGTACAGCC TGGAGCTATT GAAAGGGGTG CCGCCCTTCC
    26001 CCCGCCCAGG GAGCTTAGCG TGTTAGGCAG TTGTGAGTCC AGTGCTGGCT
    26051 GTCGCCCCTT CCCCAAGGAA CAAAAAAGAC TTAGCAGGCA GCCGCAGCCA
    26101 GTGCTGGTCG CCCCTCCCCC GGGGAGTTCC GTAGGCTTAG GCAGATTCCA
    26151 GCTGTAAGAA TCTGCGTGTT CTGGGGTTGG GACACTAGGT CCCAGTGGCA
    26201 TGGGTTCGCG AGTGAGATCT TCCAATCTGT GAGTTGCACA GTTCCGTGGA
    26251 AAAAGCACAG TTTCCCCCTC TTGGGTAGCC CGCTCACTCA CCACCTCCCT
    26301 TGGCTGGAAG GAGGGGGTTC CCCTTCCCCG TGTGTCTCTC AGGTGGGCCA
    26351 CCACACCACA CTGCTCTTCC TTCTCTCTGT GGGTCACTGC CAGCCTTCTA
    26401 GTCAATTTTG ATGAGGGAAC CTGGACATTT TGGTTGCCAG GAAGGATCAC
    26451 ACACTTATTA CAGTTTTTTT CAATGTGAGC CTCTGAGCGC TGCTGCTTAT
    26501 AGTCGACCAT CTTGGCCCCC AGAGTCACAC ATCTGTTATT TTTTGATGTT
    26551 TTGATTGTGG CAATTCTTGC AGAAGTAAGG TGGTATCACC TTATGGTTTT
    26601 GATTTCCCTG GTCATTAGTG ATGTTGAACA TTTTTTTCAT ATGTTCATTA
    26651 GCCATTTGTA TATATTCTTT CAACAACTGT CTATTTATGT CCTTAGCCCA
    26701 CTTTTTGATG GGATTGTTTT TTTCTTGCCA ATTTGTTTGA GTTCGTTGTA
    26751 GATTCTAGAT ATTAGTCCTT TGTTGGATAT ATAGATTGTG AAGATTTTCT
    26801 CCCACTCTGT GGGTTGTCTG TTTACTCTAC TGACTGTGAA GGAAAAGTCA
    26851 ATTTCTTATA CGAATTTGTC TCACTCCTAC TTCCAAATGA GATCCTGGGG
    26901 TTTTTTTTTT CTGTTAATCC TTCACAATAC TTCTCCCACT TTTTTGAACT
    26951 CATTTGTTTA TATTCTGTTG TCTGCTTCTC TTTTATAGGA ATGTGACTTC
    27001 TTATGGGCTT TCTCTATTAT ACCACATATG GGTTTTTGTT TTGTTTTGTT
    27051 TTGTTTTGTT TTGTTTTTGT CCTCGGATCC ATTCTCCAAC CTCCTCCAGC
    27101 CTTCCCGTGC TCTGTGGGAT AGACGTCTGA CTCATGAAAA CTACATTTCC
    27151 CAGGCTCCCA TGCTAACTAG CTTCCTGTTA GGTTCAGCCA ATAGGAGGCA
    27201 TTGGTGGGAC AATGGTGGGC GGGGCTATGG AAGGGCCAGA GTATTTCTGT
    27251 ACCCCGCCCC CCTGCTCCCC TTCCAATGTT CCTGGAGCGG TGTAGGACCA
    27301 ATACTGTATA TATGGAAGGA AGGCAAGGTG GATAGATTGG AAGGAAGAAG
    27351 TGACAGATGG AAAGAAGAAG TGATAAATGG CAAGCGAGGC AAGGGAGCAG
    27401 AGGATGGATG AGTGGATTGC AAGAAAGAAA AAAATGGATG AAATATAAAA
    27451 GGAGCAGGAC AGATGGATAA GTAGATGGAA GTAAGAAAAG ACTGGTGTAA
    27501 GAAAGGAACG ATTGATGATG GATGATGAAT GGATCAGTGG TGATTGGGTG
    27551 AAGGGATGAA TGGATGGATG GACAGATGGA TGAACAGATG GGTGGGTGGA
    27601 TAGATGGATG GATGGATAAA ATGGGTAGGT GGATGGATGG ATGGATGGAC
    27651 AGATGGGTGG GTAGGTGGAT GGATGGATAG ATGGATGGAT AAGTGAATGG
    27701 ATGGATGGAT GGATGGATGG ATAAATGGAT GGATGGGTGA AAGGAAGGAA
    27751 AGAAGTGAGA GAAGGAAGAG GAAGGATAGA CAGATGTTAG AAGGTACAAA
    27801 TGAAAGGAAG GAAGCCAGCA AGAAAGAAAG GATGCATTAA TAGAATGAAA
    27851 GATGGAAGGG AAGAAGAAAG GATGGAAAGA GAGAAGGAAG AATGAACAGA
    27901 AGGAAGTTCA AGAGTGGTGA AAAGAAGAAA GGCAGGGAGA GAAGGAGAAG
    27951 TAAACTTTTC TTCTAGAGAT TTGTCTTAAA CCTTAGCTTG GCTGGACACT
    28001 GTGGTTCACG CCTGTAATCC CAGCACTTTG GGAGGCCGAG GCGGGTGGAT
    28051 CATGAGGTCA GGAGATCAAG ACCATCCTGG CTAACACGGT GAAACCCTGT
    28101 CTCTACTAAA AATACAAAAA AAATTTAGTC AGGTGTGGTG GTGCATGCCT
    28151 GTGGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATAAAACCTG
    28201 GGAGGCAGAG CTTGCAGTGA GCCAAGATCA CACCACTGCA CTCTAGCCTG
    28251 GGCGACAAAG TGAGACTCTG TCTCAAACAA AAACAAAACA AAAAAACAAA
    28301 AACAAAAAAC AAAACCAAAC CAAAACAAAA AAAAAAACCT TAACTCATAC
    28351 TTTCATAAAG TTCCACACAC AGGGAGTGAT TAGAAAGCAT TTGCTGATAT
    28401 ATTTTATATA ATAAACATGT ACACCATATT GACCTGTGTG CCCAGCAGTG
    28451 CTTACATGAT TTACAATGAT TAACTTGTTT AAGCTTCATA ACAACGGTTG
    28501 AGGCAGGAAA CATCATTGTG AACCATTGTC ATCTCATTTT ACAGATGAGT
    28551 AAACTGAAGT GCTGAGAGGT TGGTTATGGC TGCAAAGATT GTTGGCCATG
    28601 TTAACCAATG CATAGAAGAT TAGCATACCT GGTTGTGAGT GCAGGAGAGA
    28651 GAGAGAAATG GGAGAAAGGC AGAGAAGGAT CGATGGGGAG AGAGGAAGAG
    28701 AGAGAGAGAG AATAAATTTT TTAAAAATGT CTAGAGTCAT GACTTCCGCA
    28751 TCAGTGTGGT AATATGCAGC CTTTACCCTG GGAAAGATCA GAACCATTGG
    28801 TACTTTTTAC AGAATCTTCC CTTCCTGCAT TTGGGTAGAA GGACCCCATC
    28851 TGGACATCCC AAATCATTAA GCACACCCTT ACTGGCTGCT GGAGTTGTCT
    28901 CCATTAAAAG TCACCGTTGG GTTTATTAAG AGGCGGACAC AGGGTCCTTA
    28951 GAACACACTG CCCCCACCTG TCCCACACCA CCCCCCACCC ACCCATCATC
    Exon R1
    29001 CTCCCCAAGA GCTTCATCTC TCTCTCTCTT CCCCCTGCCC TAGCCGGGGT
    29051 GGTCAGCGAG GAGCCATTCA CACTGAACTT CACCATCAAC AACCTGCGCT
    29101 ACATGGCGGA CATGGGCCAA CCCGGCTCCC TCAAGTTCAA CATCACAGAC
    29151 AACGTCATGC AGCACCTGGT GAGAGGCCTG CCTCCCGCTG CAGCCCTGCC
    29201 ATGCCCATCC TAGGGCTGTT GCCTGCCTGC CTCTGACCAA CCCAAGCTCC
    Exon R2
    29251 CTTCTCCCTC TGCAGCTCAG TCCTTTGTTC CAGAGGAGCA GCCTGGGTGC
    29301 ACGGTACACA GGCTGCAGGG TCATCGCACT AAGGTGAGAA ACTCCCCCAC
    29351 CCACAGCGCA CCACCAAGAA CTTAGAGTTC TGACTGGGAG GTCCCTCTTG
    29401 GGTTGGGGTG GGCTACATAT TTTTTTAAAT CTTTTTATCT TTCCTTTTTT
    29451 TTTTTTTGAG ATGAAGTTTC GCTCTCGTTG CCCAGGCTAG AGTGCAATGG
    29501 CACGATCTTG GCTCACTGCA ACCTCTGCCT CCCGGGTTCA AGTGATTATC
    29551 CTGCCTCAGC CTCCCCAGTA GCTGGGATTA CAGGCAGGCA CCACCATGCC
    29601 TGGCTAATTG TTTTGTATTT TTAGTAGAGA TGGGGTGTCT CCATGTTGAT
    29651 CAGGCTGGTC TTGAACTCCT GACTTCAGGT GATCCACCCT CCTCAGCCTC
    29701 CCAAAGTGCT GGGATTACAG GCGTGAGCCA CCATATCTGG CCCCATTCTT
    29751 TTTTTTTAAA TGAATTTAAG GAGTGCAAAT GCAGTTTTTG TTACATGCAT
    29801 ATATTCCATA GTGAAGTCTG CAGACAGTAG ACTTCCAGAC AGTAGCTTCT
    29851 GGTGTATCAC CCGAATAGTG TACATTGTAC TTATTAAGTG AGGTTCCCCA
    29901 CCCTTCTCCC ACTCTCCCAC CTTTCTGAGT ATCCAGTGTC TATTATTCCA
    29951 CACTCCAGGT CCATGCTCTC ACGTATAAGT GAGAACGTAT GGTATTCCAC
    30001 CATGAGCTAA TGGACATGGA GTCCATTGGC TCCCACTTAT AAGTGAGAGC
    30051 ATGCGGTATT TGACTATTTC TGAGTTTCAC TTAAGATAAT GGACTCCCAT
    30101 TCCATCCATG TTGCTGCAAA ATACATGATT TCACTCTTTT TATGGCTGAA
    30151 TAGTATTTCG TGGTATATAT ATATACCACA TTTTCTTTAT CCAGTCTTCT
    30201 ACTGATGGAC ACTTAGGTTG GGTCCATACC TTTGCTGTTG AAATAGTGCT
    30251 GCAATAAACA TACACGTGCA GGTGTCTTTC TTATATAAAT GATTTCTTTT
    30301 TTTCTTTCCT TTTTTTTGAT ATAACGAATT TCTTTTATTT GGGTTAAATC
    30351 CCCCAATAGT GGGATTGNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    30401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    30451 TGACCTGTCC GTATTGATAT ATAAAATGCT GCATTTAAAG TGTACAACTT
    30501 GATATTTTGG TATACATTGT TAAATCATGG CCACATTTCA GCTAATTAAT
    30551 ATATCTATTA TCTCTACATA GTTATCATGT TTGTACCCTT TGACCAGCAT
    30601 CACCCCATTT GCTCCTCCTC CCAGCCCCTG GCAACCACCA TCCTACTCTC
    30651 TGCTTCTATG AGTCTGACAA TTTTAGATTC CACCTATAAG TTAGATTATG
    30701 CGGTATTTGT CTTTCTGTGC CTGGCTTATT TCACTTAGCC TAATGTCCTC
    30751 CAGCTCCATC TATGTTATCC CAAGTGGCAG GATTTTCATC TTTCTTATAT
    30801 ATTTCATTGT ATATGTGTAT GCCACATTTT CTTTACCCAT TCATCCATTG
    30851 AAGGTCATTT AGCTTGTTTC CATATCTTGG CTATTTTGAA TAGTGCTGCA
    30901 ATGAACATAG GAGTGCAGAT ATCTCTTTAA GATACTGGTT TCATTTCTTT
    30951 CTTTCTTCTC TTTTTTTTTT TTCTGAGACA GAGTCTGACT CTGTCGCTCA
    31001 AGCTGGAGTA CAGTGGTGCA ATCTTGGCTC ACTGCAAACT CTGCCTCCTG
    31051 AGTTCAAGCG ATTCTCGTGC CTCAACCTCC CAGGGAGTTT TGCTCTTGCT
    31101 GCCCAGGCTG AAGTGCAGTG GTGCAATCTT CACTCACCAC AACCTGTGCC
    31151 TCCCGGGTTC AAGCGATTCT CGTGCCTCAG CCTCCCAGGT AGCAAGGATT
    31201 ACAGGCGCCC AACACCACAC CAGGCTAAAT TTTTTTGCAT TTTTAGTAGA
    31251 GACGGGGTTT TGCCATGTTG GCCAGGCTGG TCTCAAATTC CTGGCCTCAA
    31301 GTGATCCACC TGCCTCAGCC TCCTGAAGTG CTGGGATTTT ACAGGCATGA
    31351 ACCACCACAC ATGGCCTCAT TTCTTTTAGA TATATATGGG TTGAGCTATT
    31401 CTCAGAGGGT CCTTTTCTGC ATCTATTTAA GATCACATTT TTTTTATATT
    31451 GTGGCAAAAA TACATGTAAC ATAAAATCTG CCATTTTAAC CATTTTTAAA
    31501 TGTACAATTC AGTGACATTG ATTATATTCA CAATGTCATA CAGCCATCAC
    31551 CACTATTTAT TTCTAATACT TTTCCATTGG GTAGATCCCC AACAGTGGGA
    31601 TTGCTGGGTC AAATGGTAGT TCTGATTTTT TTTTTTTGTT TTTTGAGAAA
    31651 TCTCCATACT GTTTTTCATT TGAGGTTGTA CTAATTTACA TTCCCACCAA
    31701 CAGTGTATAA GAGTTTCCTA GGCCGGGCAT GGTGGCTTAT GCCTGTAATC
    31751 CCAGCACTTT GCGAGGCCCA GGTGGGTGGA TCATGAGGTC AGGAGATCGA
    31801 GACCACCCTG GCTAACATGG TGAAACCCCG TCTCTACTAA AAATGCAAAA
    31851 AATTAGCCGG GCGTGGTGGC GGGTGCCTGT AGTCCCAGCT ACTGGAGAGG
    31901 CTGAGGCAGG AGAATGGCAT GAACCCTGAA GGCGGGGCTT GCAGTGAGCT
    31951 GAGATCGCAC CACTGCACAC TTCAACCTAG GCGACAGAGC GAGACTCCAT
    32001 CTCAAAAAAA AAAAAAAAAA AAAAGGTTTC CTTTCAGTGC ATCCTTGCCA
    32051 ACTTGAGTTT TCTGGGTTGG TTTGCACTCT CATGGTATTT ACTAGATACT
    32101 TCTCCATTTA TATTTTTACT CAACCCATGC CCATAACACC ACTCCTCTAC
    32151 CATTCCCACC AACCATGTAT AAGAGTTCCT TTTCTTGCAT CCTTGCCAAC
    32201 TTGACTTCTT TGGGTCAGTT TGCACTCTCT TGGTATTTAC TATTTACTTC
    32251 TCCATTTATA TTTTTAGTCA ACTGATGCCC ATGGCACCGC TCCTCTGAGG
    32301 CAGGTGCTGG GTACTAGAGT GATAAGACAG ATGCTGTCCC TGCCCTCACC
    32351 CAGTGGAGAA GAACAGATGC TAAACAGGAA CATAAATATC TAAGTAAAAT
    32401 GGCTTCAAAT GGAGTAAAGT GATATGAAAC ATAAATAAAT AGCAAGTGAT
    32451 GGGTAGAGCA ACTTTACCCA GGATGAATCT TGGGCTGTGT CCCAAATGGC
    32501 CATGAAAACT GTTCCAGGCA GGGAGAACAG CATGAGAAAA GGTCTTGAGG
    32551 TGCAAATGAG CTTGGCATGT TCTATGAACA GCAAAGAGGC CAGTGTGGCT
    32601 GGAGCAGAGA GAGAGCAAGA AGAAAAGAGA GAAAGGATGA GACTCAAGAC
    32651 ATCAGCAAGT TTGAAGGGCC TTGGAGGACT TGGATTTTTT TTTTTAAGAC
    32701 AGCTTTGTTC TTGTTGCCCA GGCATGATCT CGGCTCACCA CAACCTCCGC
    32751 CTCCTGGGTT CAAACGATTC CTCTGCCTCA GCCTCCCGAG TAGCTGGGGG
    32801 TAACAGGCAT GTGCCCACCA CACCTGGCTA ATTTTGTATT TTTAGTAGAA
    32851 ATGGGGCTTC TCCATGGTTG GTCAGGCTGG TCTCGAACTC CCGACCTCAG
    32901 GTGATCCGAC CGCCTCGGCC TCCCAAAGTG CTGGGATTAT AGGTGTGAGC
    32951 CACTGCACCT GGCTTGGATT TTTTTTGTTC TATATTGTGG TAACATACAC
    33001 ATCACATTAA ATTGATCATT TTAGCTATAT TTCCCGTTCA GTGGCATCAA
    33051 GCACATTCAC ATTATTGTGC AACCATCACC ACTATCATCC ATCTCCAGAA
    33101 CTTTCTCATC TTCCCAAACT GAAACTCCAT CCCCATGAAA CACTCATTCC
    33151 TCATCCCCCT CCTCAAGCCT CTGGCACCCA CCATTCTACT TTCTGTCTCT
    33201 GTGAATCTGA TGATTCTGAG GACCTCCTAT GAATGGAGGA ATCATATGGT
    33251 ATATGTCCTG GTTTATACTG TATGGCTGGC TTATTTCACC AAGCATAATG
    33301 TCCTCAAAGT TCATCCATGT TGTAGCATGT GTCAGAATTC CCTTCCTTTT
    33351 CCACTTGTAT GTAAATGCTG TATTGTGTTT CTCCATTCAT TAGGACTTTG
    33401 ATTTTTGCAG GGAGTTGTCA AGGGGTGCTG GGTTCTGGGG CTTCAATATA
    33451 ATAAGAGTAA GCTAAACTGG TTCATTTCCT CCTTCGTGGA GACCATGTTC
    33501 TGGTAGGAAC AGGAACAAAT AATTTATGAT TACATAGAGG GTGACCAGGG
    33551 CAGTGACAGG GGAAGAGTGG AGGATTGTGG GACCCAGAGG AGGCTCCTGA
    33601 CCTTGCCTAG GAAGATAGGA GGAGGAAGAG GAGGAGGAAG AGGAGGAGGA
    33651 AGAGGAGGAG GAGGAGGAGG AGGGAGTCCT CTAAGCTGAG ACCTGGAGGA
    33701 TGACCAGGAA GTTATCCAGG TAAGGAGAAA TGGGGAGAAG CTTCCAGACA
    33751 AAAGTAACAG CAATTGCAAA GATCCTGAGA TGATAGATAA GGTCAGGTGG
    33801 AGAAAGTGCA AACTGTCAAT GAGACCAAAA TATGGACTGT GAGTTGTGCA
    33851 GTGACCACAA GTGGAGAGGT GCTAGGTGGC CTTCATCCCC CAAAGCTGCA
    Exon R3
    33901 CCTCTCCCTC CTCAGGTCTG TGAAGAACGG TGCTGAGACA CGGGTGGACC
    33951 TCCTCTGCAC CTACCTGCAG CCCCTCAGCG GCCCAGGTCT GCCTATCAAG
    34001 CAGGTGTTCC ATGAGCTGAG CCAGCAGACC CATGGCATCA CCCGGCTGGG
    34051 CCCCTACTCT CTGGACAAAG ACAGCCTCTA CCTTAACGGT GAGCAGCTAT
    34101 CAGCCCCATC TCCCTGCCCC ACCCCCCAGC CCCCACTGCA GTCCAGGAGG
    34151 GTGTCTGTTT GCCGGTTCTC TAGGGAAAGA CTTGGGGTTC AAGTCTTGGC
    34201 ATTACCACTG GCCCTCCCAT AACCACAATG CAAGGTTGGA CTTTGATTAA
    34251 TCCCATTTTA CAGATGAAGA AACTGAGGCT TAGACAGGCT AAGCAATTTA
    34301 CCTTGACAGT GGTGGAACCA GGATATGAAC TCCACTTGTC AGCATTCGGT
    34351 GCTATGATCC ACTCCACATG TTTAACTCAC AGAAGAGTCT TCCTGGTGGG
    34401 GGCACTTGGG GGACAAAAAA CACATTTCCG GCTGTGAGCA GTGGCTCACA
    34451 CCTGTAATCC CAGCACTTTG GGAGCCCAAG GCGGGCGGAT CACAAGGTCA
    34501 AGAGATTGAG ACCACCCTGG ACAACATAGT GAAACCCTGT CTCTACTAAA
    34551 AATACAAAAA TTAGCTGGGT GTGGTGGCGC ACGCCTGTAG TCCCACCTAC
    34601 TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACTCGGGAGG CAGAGGTTGC
    34651 AGTGAGCCAA GATTGCGCCA TTGCACTCCA GTCTGGGTGA CAAGAGTGAA
    34701 ACTCTGTCTC AAAAAAAAAA AAAACAATTT CCCCTCCCTG CTTTCTTCTC
    34751 ACCATTGACG AGGGATGGGC TTCTCTCCTA CCTGAGGCCC CCTATACCAG
    34801 GAAGATCTAT GGGATCTAAT CTTCAGCGCA CACTGGGCCT CAGCATTGGT
    34851 CTAGAACTCA GGATAAGATA GCATTTAAGA AGGCATCCCC TAAATGGGGT
    34901 TCTGAGAGGC AAAGCATGAC CGTGGAGAAT TGACAAAATA GCTCGCCTTT
    34951 CATCCCCTCC ACCGCCAACC CAAGAACAGT GCTTATCATC ATGACCCCAT
    35001 GAGGTGGGCA CCCCATATCA CTTATATGAG GTACCTTTAG GTAGGTACCG
    35051 GGATGTGGAG AGACATCCTG GGCTTTCATT ACTCTTATTT TAGCAAAGAG
    35101 GGAATCTGAG GCACAGAGAA GGGAAGGGAC TTGCCCATGC CCACAGCGAG
    35151 TTTTTGGCTA GTATGGGTCT TGATGTTCTT TCTGGGTCCG TNNNNNNNNN
    35201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    35251 NNNNNNNNNT TCCTGCGTGG GAGATGTGTG GATTTGATTT GTATCTGGAA
    35301 AGATGATTTT TTATTGGTGA CAAAGCAGTT AAAGTTAATC TTCACAGTTG
    35351 TGCGGAGAGT GACCACGCGA GTTAGTCTTA TCCTTATTTT TTTGATCATC
    35401 CCGCTACACA AGACAAAGCG AACCGCACAG GCAACATCAG CAGGCCCCAT
    35451 TGGTGTGTTC CCCTCTATGG GTCCATGTGT TCTCATCATT AGCTCCCACG
    35501 TATAAAGTGA GAAGATGGCA GTATTGGTTT TCTGTTCCTG CATTAGTTTG
    35551 GTAAGGATAA TGACCTCCAG CTCCAACCAT GTTCCTGCAA CGGACATGAT
    35601 CTCATTCTTT TTTATAGCTG CATAGTATTC CATGGTGTAT ATGTTCCTCA
    35651 TGTTCTTTAT CCAGTCTATC CTTGATGGGC ATTTAAGTAG ATTCCATGTC
    35701 TTTGCTATTG TGAATAGTGC TTCAGTGAAC AGGTGTCTTT ATGATAGAAA
    35751 AATTTATATG CCTTTGGGCA TATATGCAGT GATGAGATTG CTGGGTCAGA
    35801 CGGTAGTTCT GTTTTTAGCT CTTTGAGGAA TCATCCTGCT GCTTTCTACA
    35851 GTGGATGAAC TAATTTACAC TCCCACCAAC AGTGTATAAA CACTCCTTTT
    35901 TATCTGCAAC CTCAGCAGCA TGGTTTTATT TCTCTTTATG GCTGAATAGT
    35951 GTTCCATTGT GCATATATAC CACACTTTCT TTATGGATTC ATCTGCTGAT
    36001 GGACATATAG GTTGATTCCA CATCTCTGCT ATTGTGAATA GTGCTGTGAT
    36051 AAACACACAG GTGCGGGTTG GGTCTTGATG ATCTCAGTTA ACATCCAGTC
    36101 CCTTCAACTT GGCTATTGCA GGGAGCTGTT CCCCCTTGTA AACTGCACAG
    36151 CTTATGTGCT TCATTTTGTT CCTTCATTTA GATTTACCAA GCAGCTACTA
    36201 TTAACCAGGC CACAATGTGC CTCGCCCCCA GGAACAGAGA TAGGTTACAT
    36251 GTGCATCCTG TCCTAATGTA ATCTCCAGGG GGGCGGAGAC TGTTTTGTTC
    36301 TACCCTATAT TCCCCAAATG TAAAGGGAGC CTTGCACATA CTAAGCCCTT
    36351 AATAAACATT CATTGGGTGG AGGAATAGAT TGGAGGAGGC CTGGAAGGGG
    36401 AGGCGGGGGT TATGGATGGA TAGGAGGATA GACTTGTGAA CACAAAGGTA
    36451 GTGAGAGCCT CTCATTGGAG GCATGCTGGA GACGTGAGTA GGGAAGGGTC
    36501 AGTGCTAATT GAAATATCAG GAAATTCTTT CTAGTGGTGA ACACATTTAA
    36551 GTCAAATATT AGATGATACA TAAATGTATC CATAATCTCT AGATACACAA
    36601 AGGGAAAGGC ATCCAGGCAG GGGCCCCATA TGGACAAAGG CATGGAGTAT
    36651 CTGGGACGGT TCCACCACCT CCTCTTACGT GTGACTTCTT TGTTTCAAGG
    Exon R4
    36701 TTACAATGAA CCTGGTCTAG ATGAGCCTCC TACAAGTACG TGTCTTTGAA
    36751 TCTAGTGCCC ATTTCAATCT CCATGGGTCT TGGTTCAAGC TTTTCTCCTC
    36801 ATTCATGAAG GAAGGTTGCC CCAAATTCGG GCTGGTCCCC TAGGTGGTGA
    36851 GGGGCATTGT CTCAGTGGGA GGAAGAATGC TGAGTCCTTG GCCCTGTTTT
    36901 TAGACCTGCA GCCATAGTCT TGGCTTTGTG AATTTTCCAT GTCCCTCTGG
    36951 GTTGGAGGAA GAAGTTTGAA CAAGCATTCC CTACACGGGA TAGAGGTTGA
    37001 GGTCAGATGA TGACCTCTGT TAGTCTGTAC CCTCCTTGAT AAGAAAATCT
    37051 CCTCCAAGTG CCCCAGCAGA GGCTTCATGG TCAAGCTGCA GACTCTGCTG
    37101 GCTACTGGTT TTGGCTAAAT TTGCCCATTG CCTCATCCAG TGATCCACTC
    37151 GTCTATCTTT CCAGCCATCC ATTTTTCTAT CCTTCCAGTC ATCTCTCAGA
    37201 CACCACCTGT CCTTCCATCC ATCCATCCGT CCATCCATTT ACCCATCCAT
    37251 CCATCCACCC CATTTTCCTG ACCATTTACC TCCTCGTCCT TCCTTCCATC
    37301 TGTCCTTTTA TCCATCTATT CATCCATCAC CCATCCTCCT GCCCATTCAC
    37351 CTGCTTGTCC CTCCTTTCTT CTGTCCTTCT ATACATCCAT CCATCCATCC
    37401 ATCCATCCAT CCACCCATCC ACTCATCCAC CACCCACCCA TCCTTCTGCC
    37451 CACTCACTCG CTAGCCCCTC CTTCCTTCTG TCCTTCCATC CATCCATCCA
    37501 CCCATCTTCC TGCCCATTCA CCTGCTTGTC CTTCCTTCTA TCTGTCTTTT
    37551 ATCCATCTCT CCATCCATTC TCACCATCCA TCCATCCATC CTTCTCCCTA
    37601 TTCACTGGTT TGTCTTTCCT TCTGTCCTTC CAACCATCCA CCCATCTCTC
    37651 CATTCATTCT CCTCTTCATT CACCATGTTT CCTTATTTCT GTCTCTTCCA
    37701 TCCATCCATC TATCCAGACA GACATCTCCT CCCCCCATTC TCCTCCCCAT
    37751 TCACTCAATT GTCCTTCCTT CCATCTGTCC TTTTATCCAT CCATCCACCC
    37801 ATCCATCCAT CCATCTATCC TTCTCCCCAT TCACCTGTTT GTCCTTCTTT
    37851 CTGTCCTTCC AACCATCCAT CCATCCATCA TCCATCCATC TATCCTTTTC
    37901 CCCATTCACC TGTTTTGTCC TTCCTTCTGT CCTTCCAACA TCCCTCCATC
    37951 TCTCCATCCA TCCTCCTGCC TATTCATCTG CTTGTCTTTC CTTCCTTCTG
    38001 TCCTTCCATC CATTCATCCA TCTGCCCATC CACCCACTCA TCCTCTTGCC
    38051 CATTCACCTG CTTGTCCTTC CTTCCACCTG TCCTTTTATC CATCCATCCA
    38101 TCCATCCATC TTGCTCACTC CTCCACTCAC ACAATCACTC CTTCCCTCAG
    38151 TCTCATTTAT GGCCCACCTG TGAATGGTTG TCCTGGCTTG GACCACTGAT
    38201 GAAGCCCAGG GGAGCTTCTC CCACTAGTGG TGGGCTTTTG TCCTCTCTGA
    Exon R5
    38251 TGGACTGTTC CTTCCACAGC TCCCAAGCCA GCCACCACAT TCCTGCCTCC
    38301 TCTGTCAGAA GCCACAACAG GTATTTGGGG CCATTTTTCC TCCTCGAAGA
    38351 TTAGAATAGC ATTTCAATCA GACACCTGCC CTCGTGGAGT CCCAGATTTT
    38401 ATGAAATAAA TAGACCATCA TAATGTCAGA TGTTTTGGGG TGAGATACCT
    38451 GGCATAGTTG GGAAGGAGGA GGGCTTTCTG GAGAAAGTTT CACCTGAACT
    38501 GAGTCTTTAA GGATGACTAA GAGTGATTCA GGCAAATAGG GCATGAATAG
    38551 TATAACTGAA AGAGGGGAAT CTGTGAGCAA AGCCTCAGTG GCCAGAAACA
    38601 GCATAGAGTA TAGGGAGAAG TGAGAGAAAT TTGGTTTGCA TGAAACATAA
    38651 AGCTTAACCC AGAGTGGATG GATAAGTGAG ACTGAAAGGT CAGCAGGAGC
    38701 CAGATTGGGA AGGGCCTTGA ATGCCAAGTC AAGAAATTTG AACTTAACAC
    38751 TGAAGGCCAT AGGGAGCTGT GGATGGTACT AGAGCAGGGG CAGCCATAGT
    38801 GAGATTGTCA TTTCAGAAAG ATTCTTCTTG TGTTCAGTAT AGAGAATGTC
    38851 CTTTAGACAG GGCATCCAGT GAGTCTGCCA GGTGCTAATC AGGGTGAGAG
    38901 AAAATAAGAC CTGAACTGGG ATAGGGGGAG GAGAGAGAGG ATATATGTGA
    38951 TGAATATTCA GTAAAGAGAA TTGGTGTTAC TTGGAGGGGA GAAGACACAT
    39001 AGCTTCTGAC TTGCGATGGC CACACTCAGT TTAATAATGA GCGCAGTCTG
    39051 ATCTAGTCTC AGACCAGCCC TCAGTTGCAG ACGTCTCTCC TCCCCTCCTG
    Exon R1
    39101 CAGCATGGGG TACCACCTGA AGACCCTCAC ACTCAACTTC ACCATCTCCA
    39151 ATCTCCAGTA TTCACCAGAT ATGGGCAAGG GCTCAGCTAC ATTCAACTCC
    39201 ACCGAGGGGG TCCTTCAGCA CCTGGTGAGA CCCTGGTCCC AGCAGCTCCT
    39251 GGTGGGATAA ATCCTACCCC CAACCTCTGT TCCTCGGCTT ACCCTCTTCC
    Exon R2
    39301 TCCTTCCTCT CAAGCTCAGA CCCTTGTTCC AGAAGAGCAG CATGGGCCCC
    39351 TTCTACTTGG GTTGCCAACT GATCTCCCTC AGGTGAGACC ACTTCCTGGC
    39401 CATTTGCCAG TAACAACCAC CCCTTTTGTG ACCACCCCTT CCTCAGCTTT
    39451 CCCCTGCTCC TCCCTCCACT GCTCTTTACC TGCAGAGGTC TCGGGACCTC
    Exon R3
    39501 TCTAGAGTCC TCAAATGCCT CTCTCCCCAG GCCTGAGAAG GATGGGGCAG
    39551 CCACTGGTGT GGACACCACC TGCACCTACC ACCCTGACCC TGTGGGCCCC
    39601 GGGCTGGACA TACAGCAGCT TTACTGGGAG CTGAGTCAGC TGACCCATGG
    39651 TGTCACCCAA CTGGGCTTCT ATGTCCTGGA CAGGGATAGC CTCTTCATCA
    39701 ATGGTGAGTG TCAGGCTGAA CTTGGATTTA CAGTGACTTT TGGGGAGTTG
    39751 GTTTCTTTGT TTTTGAGATG GAGTCTCACT CTATCACCCA GGCTGGAGTG
    39801 CAATGGTGCA ATCTTGGCTC TGCAACAGTG ATTCTCCTGC CTCAGCCTCC
    39851 CAAGTAGCTG GGATTTACAG GTGCATGCCA CCACGCTCAG CTAATTTTTG
    39901 TATTTTTAGT AGAGATGGGG TTTCACCATG TTGCCCAGGC TGGTCTCGAA
    39951 CTCCTGACCT CAGGTGATCC ACCTGCCTTG GCCTCCCAAA GTGCCAGGAT
    40001 TACAGGCATG AGCCACCATG CCCGGCCCAC CATGACTATT ATTTGTCCCT
    40051 GTTGTATGCC CTTTCCTCTC TAAAAAAAAT AGCCCAAGGC CTGGCTGGGG
    40101 GACACCCTTC CCCAAACCAC CAAGGGGAGG GTCTTTCCCA TTATTTTGAG
    40151 TAAATAGCAT GAAATTCTTT GACCAAATTA ATGTCATAAA TTGTTTGTCT
    40201 CTTTCTCCTT CACTTTTGTT TCCAACTTGG TTGCGGTATA ACTATCAAAT
    40251 ACAATTGTAT GTATTTAAGA TGTATAATGC AGTGATTTAA TATATGTGTA
    40301 GCTTATGAAA TGATTACCAT GATCAAATTA GTTAACACTG CTTTCATGTC
    40351 ACATAGTTAC CGTGTGTCTG TGTGCGTCTG TGTGAGTTAG AGAGAAAGAG
    40401 AACATTTAAG GTCTACCCTC ATAGAAAATT TCAGGTTTAC AATACAGTAT
    40451 TATTAACTAT AATCATCAAG CTTTATACTC GATCCCCAGA ACTTATTCAT
    40501 CTTGTAACTA AAAGTTTGTA TTTTGTGACC AACATCTCCC CATTTTCTCT
    40551 ATCACCACCC CCATGCCCCC AGCCCCTGAT AACCATCATG CTACTCTCTG
    40601 CTTCTGTAAG TTTGACTTCT GATCCCACAT ATAAGTGAGA TCATGCAGTA
    40651 TTTGTTTCTC TCTATCTGGT ATATTTCACT TAGCATAATG AACCCCCCCC
    40701 AGGTACATCC ATAATGAATT TCAATTCAAA ACCCAAGTGG CTGAGTCGTG
    40751 GCATCCTTTG GGACAGGATA GCAGGTCCCT TCTATATAAG GATCCTCTGT
    40801 GTCAGTGGTT ATTACCAGGG GACAATTCTG CACTTCTGCC CCACCCCACC
    40851 CCCCAACTGG GAGACTCTAG GCAATATCCG AAATCATTTT TGGGTATCAC
    40901 AACTCAGGGA GGGAAGGAGG GTGCAACTGG CACCTAGTGG GTCGGTAGCC
    40951 CATTTTCCAG TGCACAGGAG ACAACCACCC CAGGGAATGA TCCAGCCCCA
    41001 AATGCCAATA ATTTCAAGGG TGAGAAATCC TGTTGTACAT GGTCTCAAAG
    41051 TTCTTAGGTG GGCACAAGGC TGACATTTAT CACACTTTAC TGTAATTACT
    41101 TGTTAAATTT ATCTGATTCC CCCTTACCCT GTGAACTCAA CAAAATTACG
    41151 GTCTATTATG AGTGCCACTG TACCCTCGGT TCGCAGTACA TCAGCACATC
    41201 ATAGTATGGA AAGAATCATT GAATGAGTGA GCAAATTAAA GATTTGTGTC
    41251 TCTGCTGTAA CTCACATTCA TTAATTCATT CATTCAGCAA ACATATATGG
    41301 GTGGCTGTTC TGCCCCAAGC CTTGTACTGG GTCTGGAGAT AGAAGACACA
    41351 TTTTTCTGTC TCTGAAAAAC TCATACTCAA GTTAACAACA AATTACGGGC
    41401 ACAACAAAGA CCCCACTGCT GTTATTAACA GGGTACTATG GGAGCTGAGA
    41451 GGAGGAGTAA ATTAAGGAGG GCTTCCTGGA GGAGGGTGTT ATATACCCGG
    41501 CCCTGTGCCG GGACACATAA TGATAAGACA GACTTGGGCC TCTGCTGTCC
    41551 TGGAGCTCCC TCTCACTGGG CTCTTGAAGC GTGAGCAGGA GTTTTGCAGG
    41601 AAATGAAAAG GATGCATTCC TAGAAGTGGG AACTGCATAG CACATGCAGG
    41651 AAAGCTCAGC TCAGAAGAAT CTGTGTAATA TTCCATTTTT CCCTCTCTTT
    41701 GGGGCAACTT TCTGTCTAAG AGCTCCTGCA ATGCCCAGCG TGTGGACCTG
    41751 AAATTGATTC TGACAGTAGG CAGGGGACTG CTGGGCAACT TTGGCTCTGC
    41801 ATTTTGTGAT CAACATTTCC CCACCATATG TTGCCTTTTC TTCTTCTCTG
    Exon R4
    41851 TGGCTCCAGG CTATGCACCC CAGAATTTAT CAATCCGGGG CGAGTACCAG
    41901 ATAAATTTCC ACATTGTCAA CTGGAACCTC AGTAATCCAG ACCCCACATC
    41951 CTCAGAGTAC ATCACCCTGC TGAGGGACAT CCAGGACAAG GTGGGGCATC
    42001 TCTCACCCCT CCCGTCTTCT CTGTCCTGTG TGCTTCTCTC CCTCTTCTAC
    42051 CTGATTTCTC TGTTAAGTGA TCACTTTAAA TGCTTCACTT CACTATGTAT
    42101 TCTGGGTTCT CTCTCAGTTT CCAAAAGTAC TCTCTTGACT ACCATTCCCA
    42151 TTTCACAGAT GGGCAAACTG AGGCTCAGAA AGGGGCGTGG TGTGCCTAGG
    42201 GTCATACAGT GCTTTAGGAA CAGAGTTAGG ATTTGAACTC TGGTCCCCTT
    42251 TGCTCCAAGT CCTGTGTTTT TTTCCACTGG CATCAGCGGC CCCTCCACCC
    42301 CCAAGAGGCC TCCATCTCAC CCACTCTCCC TACCCATCTT TCTAGGTC
  • [0055]
    Table 3
    Genomic Carboxy Terminal
    (SEQ ID NO:3)
    Exon C1
    1 ACCACACTCT ACAAAGGCAG TCAACTACAT GACACATTCC GCTTCTGCCT
    51 GGTCACCAAC TTGACG TAAG TTCTGAAGGT CATAAGCAGT GACCAAGCTT
    101 GTGGCTGTGT CTCTGAGCAC CCTTGAGCTA GACGTCCCCA GTGGGGTACC
    151 CATTCTCCCC TACATCCCTG TCTAGCTAAT CCTACCATCT CCTCCCATAA
    201 ATCCTCAAGG TAGGGAGTGA GGATTAACCT CATGGGGCCA CCAACTCCCA
    251 GCATACACCT TCTTTTTTTT CTGGACACTT GGGAPAATAT AACTTTTTGA
    301 TGTAGAACTC AAAATATTAG CCCAATAATA ATATTTAACA TCAACCAGCC
    351 TCCTCTCATT TAATTCTCAC AACAGAATCT ATGAGTTGAG TGCAAAAATC
    401 ATCCCTATTG TGCAGATGGG AAAACTGAGG GTCAGAAAAG TGAACTTCCC
    451 AAGAACTGTC AAAGTTGGGA TTTGAACCCA GGTCTCTGAT GACTGGATGA
    501 AGGAATGAAG ATACCTATAC TTGGGAATGA GGAGGGTCGA CAGGACACGA
    551 GGGCTGACTT TGTATATTTC TAAACTTCAA AGATTTTCTG TATTTCAGCT
    601 GGGAATATGG TAGAAGGTTA ATTGGAACAA AAAAATGCAA AGCAATGAAT
    651 AAGACCTCAG TATTTGCTAT GCACAACAGG GTGACTGTAG TCCCACAAAT
    701 AACTTCACTG TACATTGTTA AAATATAACT AAAGGTGTAT GCTTGGATTG
    751 TTTGCAACAC AAAGGATATA TGCTTGAGGG GATGGATACC CCATTTACCC
    801 TGATGATTAT TATGCATTAC ATGCTTGTAT CAAAACATCT CATATACCCC
    851 ATAAATATAA AAACACCTAC TATGTACCCC AAAAAATTAA AAACAAATAA
    1051 AGGCATGGTG GCACACACCT GTAGTCCCAG CCACTCAGGA AGCTGAGGTG
    1101 GGAGGATCGC CTGAGCCTAG GAGGCTGTAC TCCAGCCTGG GTGACAGAGC
    1151 GAGACTCTAT CTCAAAAAAT AAAATAAAAT AATAAAAAGT AGAAATCAAG
    1201 AGGGAAAATG TGGGAGAAAT TGGGATAATT TTAACAATAC CTTCCACCAG
    1251 AGTGATGATG AAGAATGCAT AAGTCACTTC TTAGTGGTCT TGATCTATAA
    1301 AAAGTGTTCA ATAAATATCG ATTATTGTTA CTGTTATTGC TTCTAGACGT
    1351 AATTCCTGGA AGCATTTTTT TTTTTTTTTT TTTTGAGATG GAGTCATGCT
    1401 CTGTTGCTCA GGCTGGAGTG CAGTGGTATG ATCTCGGCTC ACTACAACTG
    1451 CCTCCTGGGT TCAAGCAATT CTCCTGCCTC AGCCCCCCAT GTAGCAGGGA
    1501 CTACAGGCAT GCGCCACCAC ACCCGGTGAA GTTTTGTATT TTTATTAGAG
    1551 ACAGGGTTTT GCCATGTTGG TCAGGCTGGT CTCGAACTCC TGACCTCAGG
    1601 CAATTTGCCT GCCTCGGCCT CCCAAAGTGC TGAGATTACA GGCTTGGGCC
    1651 ACTGCATCCA GCCGAAGGCC TCCCATTTTG ATCAGAACCC TTCTCTAGAC
    1701 TGAGGGTGGG TGCCTCTAGA TCTTTTGCTC TTTAAAGACA GCAACCGATG
    1751 ACCCTGCTGA TGCTGAGTAC TGGCTGAATT CCTGTGGTCT CTGTCCCTAG
    Exon C2
    1801 GATGGACTCC GTGTTGGTCA CTGTCAAGGC ATTGTTCTCC TCCAATTTGG
    1851 ACCCCAGCCT GGTGGAGCAA GTCTTTCTAG ATAAGACCCT GAATGCCTCA
    1901 TTCCATTGGC TGGGCTCCAC CTACCAGTTG GTGGACATCC ATGTGACAGG
    1951 TACAAGGTGG GGTGGCTGGT TTCCTAACTG GAAGAGGTGG GGTTATGAGG
    2001 AAAGATGGGG CTTCTCGGTA CCAGTGGAAT TGGTGGAGGC TCTAGAGAGG
    2051 GAAAGGGAGG CTTTCTGGAG ACCCATGTAG GTGACCTCTG GCAGTAGATC
    2101 ATCCAACGAG GCAGGAACAG AACACCAGCC ATTGCATCTA AGAGAATAGC
    2151 TATTTTTACA TGTAAAAAGA ATTGTGTTGA ATGAATGAAT CAATAGATCA
    2201 TTTATTTTGA ATCAATTTAT TGATTCATTC ATTTAATTAA TGAATAATAA
    2251 ATGATTCAGT ACATAATTGA TTAATTGATG TAATTGAGAA TTGATTTAAT
    2301 TGATTAATTG ATCAATTAAA ATGATCAATT AAATGAATGA ATCAGTAAAT
    2351 GAATAATTCA TTCATTCAAT AAACAATGGA AGTAGGCCGG GCATGGTGGC
    2401 TCACGCCTGT AATACCAGTA CTTTGGGAGG CCCAGGCAGG CAGATCACGA
    2451 GGTCAGGAGA TTGAGACCAT CCTGGCTAAC ACGGTGAAAC CCTGTCTCTA
    2501 CTAAAAATAC AAAAAAAATT AGCCAGGCAT GGTGGTGGCC ACCTGTAGTC
    2551 GCAGCTACTC GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGCA
    2601 GAGCTTGCAG TGAGCCGAGA TCGCGCCACT GCACTCCAGC CTGGGCGACA
    2651 GATGGAGACT CTGTCTCAAA AATAAATAAA TAAATAAAAA TAAAAAATAA
    2701 ATAAACAATG GAAGTAAACA CGTACTGATA ACACAGTGTG ATCATTGCTA
    2751 TGATAAGGGA ATTTCAGGGG CCTGTGGGAG CCCCAAGGAG GAACACACAA
    2801 CCTTGTCTTG GAAAGTTTTA TGTAGGAAGG GGTGAAGAAG CTGAGATCTG
    2851 ACAGAGAATG GGACCTAGCC AGGGGTAATA GATGGAGAAT TGTGCTCCAT
    2901 GCATCTATAA CCTAGAAGAT AGAAAGAATA TGGCATCTGG CCGGGTGCGG
    2951 TGGCTCACGC CTGTAGTCCC AGCACTTTCA GAGGCTGAGA TGGGTGGATC
    3001 ACCTGAGGTC AGGAGTTCAA GACCAGCCTG ACCAATATGA TGAAACCCCA
    3051 TCTCTGCTAA AAATACAAAA ATTAGCCAGG CATGGTGGTG CGTGCCTGTA
    3101 ATCCCAGCCA CTTGGGAGGC TGAGAGAGGA GAACTGCTTG AACTCGGGAG
    3151 GCGGAGGTTG CAGTGAGCCG AGATTGTGCC ATTGCACTCA AGCCTGGGCA
    3201 AAAAGAGCAA AACTGCATTT CAAAAAAAAA AAAAGTGGCA TTTTGGGGCA
    3251 AGTTTAAGAA GATTGGTGTA GCTGGAGCAT CCACTTTGAT ACTGGAGAGG
    3301 TGACAGTTGA AGCCAAAGAT GTGGGCAGAG ACTTTGTTGG GCACTGGAAT
    3351 GGCTTGGGGA GGAACATGAC ACACTCATGA GTTCTGCTTT AGAAAGAAAA
    3401 TGAAATGAAT TCTGCTCATC CTCTGGGTGC TGTGTGCAGA ATGGAGGGTG
    3451 GGGGGAGAGA AGAGCAAAGG CAAGAAGACC CTTTAGGAAC AATGATCATT
    3501 AGTTAGAAGA CTCTGGGTTT CTCAGCACCT GCAATTGCTG ACTACACCCC
    3551 CAGAGAAACC CAGTCTCTTT TCCCCCATGT TGTAGAGAAT TCTTACAATG
    3601 CTTGGTAGAA AGAGAATTGA ACAGGTAGAT GGGTGGATGG ATACAAGCTG
    3651 GACAGATGGA TGGAGGAAGA TCCTCCATCC AATATAGAGC TGTTACCTAA
    3701 AACCCTCCAT CCCACCTTTA AAATCCTAGC TCAGCCAGGC GCGGTGGCTC
    3751 ACACCTGTAA TCCCAGCACT TTGGGAGGCC AAGGCGGGTG GATCACTTGA
    3801 GGTCGGGGGT TCGAGACCAG TCTGACCAAC ATGGTGAAAC CCCCTTCTCC
    3851 ACTAAAAATA CAAAAAAAAA AAAAAGTTAG CCAGGCAGGG TGGCGCATGC
    3901 CTGTAATCCC GCTACTCGGG AGGCTGAGGC AGGAGAATGG CTTGCACCCA
    3951 GGAGGTGGAG GTTGTGGTGA GCCAAGATCA CGCCATTACA CTCCAGCCTG
    4001 GGCAAAGAGA GTGAAACTGT CTCAAAAAAC AAAACAAATG ACCCCCCTGC
    4051 CAAAAAAAAA AAAAAAAAAA AAGAAAAGAA AAAAAGAAAA GCCTAGCTCA
    4101 GCTCACACTG TCAGGAATAA GTAAGCTAGC TGGAATCATC TCTTTCTTAA
    Exon C3
    4151 AACCCTGCCT TGATAGTGGA TTTTTACATA CTTTTTTTTT AATTCTAGAA
    4201 ATGGAGTCAT CAGTTTATCA ACCAACAAGC AGCTCCAGCA CCCAGCACTT
    4251 CTACCTGAAT TTCACCATCA CCAACCTACC ATATTCCCAG GACAAAGCCC
    4301 AGCCAGGCAC CACCAATTAC CAGAGGAACA AAAGGAATAT TGAGGATGCG
    4351 GTGAGAAGGG GGTGGTATGT CCACTCTGTT GCCATGCAGA AACTGACTTA
    4401 TGCATACTGG GTAGCCACAG GGTGACTTTT TATAACAATC CACAAAGACA
    4451 GGTTCTTATT CCCATTTAAT ACACAAGCAC AGAGAGGTTC AGTAGCTGAC
    4501 CCAAGGTCAC ACAGCTAAGT CATACCCTAG AAGAGCATGT CCTTTGATAT
    4551 ACATACCTGG GCAAGTGGTT GTCATGACAA GAAGCAAAAT AGACGGAGAA
    4601 GTGTGCTCAG TGGCTGAAAA TTCTCTGATG CTACTGGGGC CAGGATTCTG
    Exon C4
    4651 ACCTAAGAAA CATCGCCCTG TCTTTCAGCT CAACCAACTC TTCCGAAACA
    4701 GCAGCATCAA GAGTTATTTT TCTGACTGTC AAGTTTCAAC ATTCAGGTAA
    4751 GTTCTAACTC AGGACCTAAT GACTCTAGGA ACTTCTGCTG TCCTTTAAAT
    4801 AGAAGTGTCC CCAAGCCATA GCTTTGATGG AAGAGAGCCC TAGAAATAGA
    4851 GAGCTGTTAA CTAAAAACTA GCTTTTTCCT AAAGCTGGAG CCCAACTGGC
    4901 TTCAACACTC AAGAGAGCTG GTGTAAATCT CAGCAGACAT AAAGGTACCT
    4951 GGTGCTGAGG CCATGGAGTC TAGAGTGTAG AATCTACTAC ATTAAGACAT
    5001 CAGCTACTGA AATCAGGACC CATGGAAGAC GGGGGAAGGA GGGGACTAAA
    5051 ACCAGATTAC TTAGAATCTA GCAGCCTAAC TGTGCTTTTC AATGAGAGGT
    5101 ATCATTTCCA ATGGTGGGGG GTACCAATGA TTTTTTTTTT TTGACAACTG
    5151 CCTTGAGAAC AGGCTTTCCT CACTAAACAA ATTCTGAATC AGAACAAATA
    5201 AAGATAAGCC CTGAGAATAG GGCTTTTTCA AGGAGCTGCC AAACAGATCA
    5251 AATAGTGACT ATGTTCTGCA GATTGATGTC TGGAGAACTC TACAGCTATT
    5301 TTGACTGCTA GGCAGCTGGT TTTCACAGAT ATCATGATTC TGAGGCTGCC
    5351 AGTTTTCAAA GTTACCGAGG ATCTTGCTGG ATGCAGTGGC TTGCGACTGT
    5401 AATCCCAGCC CTTTGGGAGG CCAAGGTGGG TAGATCGCTT GAGCTCAGGA
    5451 GTTTGAGACC AGCCTGGGCA ATATGGTGAA AACCCATCTC TACAAAAAAT
    5501 ACAAAAATCA GCTGAGCATA GTGGCATGTG CTGTAGTCCC AGTTACTTAG
    5551 GAGGCTGAGG TGGGAGGATG GCTTGAGCCC AGGAGGCAGA GGTTGCAGTG
    5601 AGCTGACATT GTGCCATGCA CTCTAGCCTG GGCAACAGAG CCAAAGCCTG
    5651 TCTCAAAAAA AAAAAAACAA ATAATAATAA TAATAAAATA CTGAGGATCT
    5701 TGAAAGAGCA CTGTGGAAAT AATGCAAGTT AAAATGCCAC AAAGCTTGCT
    5751 CTTTTTACTG AGATTTAACA CTTTCCTTAA CTAAACACCC CTCGAATTTT
    5801 TGCAAGCCTT TGGTTCACTT CTAGACTTCT GGPAAAATTG ATTTGGACTA
    5851 TTTTGGCCAA TGTTCTCATT GATTTTATGG GTATTCAGAA GTTGTTACCC
    5901 CAACATTCCA GAAATGTTCT CCCTGTGGCT ATTACTTTAT TTATTTATTT
    5951 ATTTATTTAT TTATTTATTT ATTTGAGACG GAGTCTCCCT CTGTTGCCCA
    6001 GGCTGGAGTG CAGTGGCGCA ATCTCAGCTC ACTGCAACCT CCGCTTCCCA
    6051 GGTTCAAGCG ATTCTCCTGC CTCAGCCTCC CAAGTAGCTG GGATTATGGA
    6101 TGTGCACCAC CACACCGGCT AATTTTTGTG TTTTTAGTAG AGATGGGGTT
    6151 TCACTGTGTT GGCCAGGCTG GTCTCGAACT CCTGATCTCA AGTGATCCAC
    6201 CCGCCTTGGC CTCCCAAAGT GCTGGGATAA CAGGCATGAG CCACTGTGCC
    6251 TGACCTCCCT GTGGCTATTT TTAAATGAAT TAAGTGGAAT AAAATTAGAA
    6301 ATTCAGTTCT TCTCCCACGC TAGCTGCATT TTAAGCATTT AATAACAACA
    6351 TGAAGCTACT AATGGCTGCA TTGTGTAGTG CAGATGTAGA ATTTTTTTTT
    6401 TGTTTTTTGT TTTGTTTTTG AGATGGAGTC TCGCTCTGTC ACCAGGCTAG
    6451 AGTGCAGTGG CGTGATCTCG TCTCACTGCA ATCTCTACTC CCCGATTCAA
    6501 GTGATTCTCC TGCCTCAGCC TCCCAAGTAG CTGGGATTAC AGGCACGTGC
    6551 CACCACACCC AGCTAATATT TGTATGGATG GTCTCAATCT CCTGACCTCG
    6601 TGATTTGTAT GGATGGTCTC GATCTGACCT CATGATCCGC CTGCCTGGGC
    6651 CTCCCAAAGT GCTGGGATTA CAGGCGTGAG CCACTGTGCC CGGCCGACAT
    6701 AGAATGTTTA CATCATTGCA GAAAGTTTCT GCAGGAAGAG CCTAGAAGGA
    6751 GAAAGCCTAG AATCATGATA AAATTGCAGA TATCTTTGCT TATCCCTGTC
    Exon C5
    6801 CCCTTCCAGG TCTGTCCCCA ACAGGCACCA CACCGGGGTG GACTCCCTGT
    6851 GTAACTTCTC GCCACTGGCT CGGAGAGTAG ACAGAGTTGC CATCTATGAG
    6901 GAATTTCTGC GGATGACCCG GAATGGTACC CAGCTGCAGA ACTTCACCCT
    6951 GGACAGGAGC AGTGTCCTTG TGGATGGTAA AGCTCCCTGG GTCATTGGGA
    7001 CTGAGGTGGA AGCTCCCACT TCCTCACCTG GGTCCTTCCC TGGGAATCTG
    7051 AAGGCTTGGG GTTGATTCGT CATCGAGCTT TCTCAGACTG GGAGAAAGTG
    7101 GCTTAGTTCT CCTAAGCTTT ACCCATCATT GAAGGAAAGA AAAGGACGCC
    7151 CGAGGGATAT GGGAGGCATT TGCCCTCTTC TGGCCAGCTC TGTGACCTCA
    7201 GGCTAGTCAC ATCTCCTTTC TGGACTTCTT ATCTCTCTGT ACTTAGCAAG
    7251 CCACTTGGTT TTTGGTTCCC ATCTTGCCTG CCCTAGATGG TATTGCTCCT
    7301 CCACCCCCAG GCAGCTGCAG TGTTAAACAA TTACCCTGAT TAGTTATTGT
    7351 TGTTGTGTTG TTTGTTTGTT TTTGAGACAG GGTCTCACTC TGTCACCTAG
    7401 GCTGGAGTGC AGTGACATGA TCTCAGCTCA CTGCAACCTC AACCCCTGGA
    7451 CTCAAGCAAT CCACCCACTT CAGCCTCCCA AGTAACTGGG ACTACAGCCA
    7501 TGCGCCACCA CACCCGGATA ATTTTTGTAT TTTTTCTAGA GATGGGGTTT
    7551 TGCAACATTG CCCAGGCTGG TCTTGAACTC CTGAGCTCAA GCATGCCACC
    7601 TGCTTCAGCC TCCCAAAGTG CTGGGATTAC AGGCAGGCAG GCACCACTGC
    7651 AGCTGGTTCT GGTTTTTTGT GTTTGTTTTT TTCTTTTAGA GGCAGGGTCT
    7701 CGCTCTGTTA ACCAGAATGG AGTACAGTGG TGCAATCATA GCTCACTGCA
    7751 GTCTTGAACT CCTGGGCTCA AGCGATCCTC CCACCTCAGC CTCCTGAGTA
    7801 CCTGGAACTA CAGGCACGTG TCACCACGCC TTGCTAATTT CTAAATTTTT
    7851 TGTAGAGACA GGGTCTCACT ATGTTGCCCA GACTGGTCTC TAATTCCTGG
    7901 CCACAAGTGA TCCTCCTGCC TCAGCAGGTC AATGAGGGCT TCCAGTTTCA
    7951 AGTTGTATGT GATTCATCCT CAACAAATGT GGTAGGATGG ACCTATTTTC
    8001 CAACTCCAGA GATGGCTTCA AGGTGGCTCA ACTTTGCATA TCCAATTTTA
    8051 CCCATTCAAA GAATAGTTAT ATACATTGTA CCATGTATCA GGAATATAAC
    8101 AGAGAGTAAC TGTTTGCTCT TTCACCACTA TATTCCAAGA ACCCCATATT
    8151 CTGCCTGGCA CATAATAAAC ACTCAAGTCA TATTTGCAGA AGGAATAACT
    8201 AGATTTCATA CAAGGTTCTT TTCAAGTCAA ATGCGAATAA CGTTTTAGAC
    8251 GGGACCTTCC AATGCCTGTG TGCACTGTCC TTGATTCCGA ATTATTGTTG
    8301 TGCAAGAGAG CACTGTTGAT CCTTCAGAAT CAACAAGCCT TTCACATGCC
    8351 TGTCACAGGT TTTTCTTTTT CTTGTTTTAC CAATTTTGTT TGTTGTTTGT
    8401 TTGTTGTTAT TGTTTTGTTT TGTTTTTGTT TTTTATTTGT TTTTATTTTT
    8451 TCTTTTTTTT TGAGACAGAG TCTCGCTCTG TCACCCAGGC TGGAGTGCAG
    8501 TGGCACGATC TCCGCCCACT GCAAGCTCCG CCTCCTGGGT TCATGCCATT
    8551 TTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTACAGGCGC CTGCCACCAT
    8601 GTCTGGCTAA TTTTTTTTGT ATTTTTAGTA GAAACAGGGT TTCACCATGT
    8651 TGACCAGGAT GGTCTCGATC TCCTGACCTC GTGATCTGCC CACCTGGGCC
    8701 TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCACACCC AGCCCCAATT
    8751 TTTTTTTTAA TTAAAATTGT TGTCAGCTCA CAAGCTTTCT AAAAACAGGC
    8801 CATGGACCCA GCATCGCTGT AGTTTGCCAA ACCCTTGCCT TGAATCAGTA
    8851 CCATCCAATA GAACTTTCTG CAGTGATAGA AAATGTTTCT ATCTGTGCTA
    8901 TTCAGCACAA AGCCATGTGT GATTACTAAG CTTGAAGTGT GGTTAATGTA
    8951 ACTGAGATAC CGAAGTTTTA ATTTTATTTA ATTTTAATTT AAAAAGCCAC
    9001 TTGTGGCTGC TCCATATTGC ACACTACTTT TTAAAATTAT TATTTGTATA
    9051 TATTTAAGGG GCACAAGTAC AATTTTGTTG CATGGATTTA TAGCCCAGTG
    9101 GGGAAGTCTG GGCTTTTAGG GTATCTATTA CCTGAATAAT GTACATTGTA
    9151 CCCATTGAGT AATTTCTCAT CATCCACTCT CCTCCACTCC CCAACCCTTC
    9201 CAAGTTTCCA CTGTCTATTA TTCCACTCTC TATGTCCATG CCTATGCATT
    9251 ATTTAGCATT GACATGTCTA TGCATTATTT AGTCAAATAC ATGTGCTATT
    9301 TGACTTCCTG TATCTGAGTT GTTTGACTTA AGATAATGAC CTTCACTTGC
    9351 ATCCATGTTG CTGCAAAAGA CATGATTTCA TTCTTTTTTA TGCCTGGGTG
    9401 GTATTGCATT GTGTGTGTGT GTGTGTGTGT GTGTGTAGAG AGAGAGAGAG
    9451 ATCACATTTT CTTTATACAG TCCTCCATTG ATGGGCACTT AGGTTGATTC
    9501 CATATCTTTG CTATTGTGAA TAGTTTTGTG ATAAACACAC AGGTTCAGGT
    9551 GTCTTTTTGA CAAAATTATT TATTTTCCTT TGTGTAGATA CCCAGTCGTG
    9601 GGATTCCTGG ATCAAATGGT AGTTTCATTT TTAGTTATTT GAGAAATCTC
    9651 CACGTTTTTC ATAGAGATTA TACTAAATTA CATTCCCACC AACAGTGTGT
    9701 AACGGTTCAC TTTTCTTGCA TCCTTTTTAA CATCTGTTAT TTTTGTCTTT
    9751 TTAGTAACAG CCATTCTGAC TGGCGTAAGG TGGTATCTCA TCATGGTTTT
    9801 AATCTGTATT TCTCTGATTA TTAGTAATGT CGAGCATTTT TTCATATGCT
    9851 TGTTAGCCAT TGGTATGTCT TCTACATCTT TAAGAAGCTG GCTATGGGCT
    9901 GGGCGCAGTG GCTCACACCT GTAATCCCAG CACTTTGGGA GGCCGAGGCA
    9951 GGCGGATCAC GAGGTCAGGA GTTAAAAACC AGCCTGGCCA ACATGGTAAA
    10001 ACCCTGCCTC TACTAAAAAT ACAAAAAATT ACCCAGGCAT GGTGGTGCGC
    10051 CTGTAATCCC AGCTACTCAG GAAGCTGAGG CAGGAGAATC ACTTGAACCC
    10101 AGGAGGCGGA GGTTGCAGTG AGACGAGATC ACATCATTGC ACTCCAGCCT
    10151 GGGTGACAGA GTGAGACTCT ATCTTGAGAA AAAAAAAAAG TTGGCTATAA
    10201 CAGGGTTGTA GAAGTAGAGG AACCAGTAAC CCTTCTCGCC ATGCCTGATG
    10251 ATGGCTTTAC ATCCCTGTCT TCATGGAGTT TATGCTGTCG TGAGGAATAA
    10301 CAAGAACAGG CAGTTGTCAA TTATAAATTA TTTGATGTGA ACCTATTCAT
    10351 ACATGGGTGT GGTCATCAGG GAAGGCTTCC TGGAGGAAAT GACATTGAAG
    10401 GTGAATTCTA AAAGATGACG ATAAACCACC AAGTGAAGGA GAGCTTAAAT
    10451 GTGTTTTTAG GCAGAAGAAA AACCTTTTGG GTGAAAATTT TAAAACTTAG
    10501 AGAGGTCCCA TCAGTTTCCA ACTGCGATGA TCCATTCTCT CCACCACTGC
    10551 CCTTGGGCCC AGCCCAATTT AGGTCCACCA TGCCCAGAGG CATGAATTTA
    10601 ACTTATGACA CTCTTGTGGT GGAATAATGG CTTTGGGCTT ATGTAGCCAT
    10651 GTGTCATTTT TTTAGAGATA CAAATTGAAA TATTTGGGGT GAGATGTCAT
    10701 GGTGTCTACT GGCCTCTAAA ACTTCAGTGA AAACATTTAC TTTCACTGAA
    10751 ATGTCAATAA ATCATAAATT GGATGTATAT GTTTTAGTTG GAGGAAATAT
    10801 AAACCACTAA ATCTAGGTGA TGCATATTTA TTATACTCTT CTCTCTGCTT
    10851 TTTTGTACGC TTGTAAAATT GTATTTAAAA GAATAAGACA CACTTGGCCG
    10901 GGCGCGGTGG CTCACGCCTG TAATCCCAGC ACTTTGGGAG ACCGAGGTGG
    10951 GTGGATCATG AGGTCAGGAG TTCAAGACCA GCCTGGCCAA CATGGTAAAA
    11001 CTCCATCACT ACATACAAAA ATTAGCCAGG CATTTTGGCG GGCACCTGTA
    11051 ATCTCAGCTA CTTGGGAGGC TGAAGCAGGA GAATTGCTTG AACCCGGGAA
    11101 GCAGAGGTTG CAGTGAGCCA AGATCACGCC ACTGCACTCT AGCCTGGGCA
    11151 ACAGAGCAAG ACTCCATCTC CAGAPAAAAA AAAAAAAAAA GACACACTCA
    Exon C6
    11201 CATGCACCCT CCATTTCTTT CATTTCTAGG GTATTCTCCC AACAGAAATG
    11251 AGCCCTTAAC TGGGAATTCT GGTAAGTCTC AAAGAAGCCC CAGCCCAGGG
    11301 TAGGGAGGGG GTAGCCTGAT GGTGCTTTGC CTTGTCCAAG AGCACCAGGC
    11351 ACACAGAGTC TTGGATGAGG ATCAAAATTG CCAACCCATG GCAAAGACTA
    11401 TTGAGGCATA GTAAAGGGAT AGCAGGGATC CTGGCTTTCT GGGGGCCCAG
    11451 TTTTTGGGGG CATCAGAGGC ATGAGGTGTT GAGCCACTAA GCTCTCTTCC
    11501 CCAGGGGCTG TGCCCATCCT CAGGCCACAT AGGGTCCAAG AAGGAGCCCT
    Exon C7
    11551 GGGACGTGGC AGGAGGTGGC TCACCCCAGC CCTTGTCTCC CCAGACCTTC
    11601 CCTTCTGGGC TGTCATCCTC ATCGGCTTGG CAGGACTCCT GGGAGTCATC
    11651 ACATGCCTGA TCTGCGGTGT CCTGGTGAGC AAGGAAGGGT TGCTTGTCTT
    11701 CTTAACAATT GGGTTGTAAG AGTTCTTAAT ATATTATAAA ACCATACTAT
    11751 ACTATACACA AGTCCTTTGC TGGATATATG TTTTGCAAAT ATTTTCTCCC
    11801 AGTTCACGGA GTGGCTTTCC TATTTTCTTT TTATAATTTT ATTTTTAATT
    11851 AATTGACAAA TAATGAATGC ATATATTTAG GGGATACAAT GTGATGCTTT
    11901 GGTATATGTA CAATTATGGA ATGACTCAAT CAAGCTAATT AATATGTCCC
    11951 TCACCTCTCA TACTTATTAT TTCTTTGTGG TGTGAACATT GGCAACCTAT
    12001 ACTCTTAGCA ATTTTGAAAT CTACATTATT ATTAACTATA GTTACTATGT
    12051 TATGCAGATC TCAAAAACTT CACAACCTAT ATGCTGATTA CAAGATATTG
    12101 AGAGAAAAAG TGATTGCAAA GAGTGTAAAT AAAATAATGT AAGAGGGAAA
    12151 AATGTAACAA AATTAGTCGT TAGGGAAATG TACACGGAAG TCACAATGAG
    12201 AGGCCACTTT TCACAAGAAT GGATAAAATT GAAAAGATTG ACTATAACAA
    12251 GTGTTGGTGA AAATGTGACA GAACTGGAAC TCTCATAAAG TGAAAGTGGA
    12301 AAATAGCTTG GCCATTTCTT TGAAAATTAC ACACACCTAC CGTAAGACCT
    12351 ACCATCCCAC TACTAGTAAT TTATCTAAGA GAAATAAAAA CATATGTCTA
    12401 TATGAAGACT TGTACACAAG TAAATGTTCA TAACAGCTTT GTTTGTAATA
    12451 GCCAAACTCT GAAAACAAGC CCCTAATGTC CATTAACAAA TATATCCTGA
    12501 CAATGGAATA TTATTCAGCA ACAAAAAGGA ATTATTAATA CATTAATAAA
    12551 TTATACAGCA ACATGTATAA ATTGCAAAAT AGTTATGCCT AGTGAAAGAA
    12601 TCCAGATGAA GAAAAGAGTA CATGCCATAT GATTCCCTTA ATAGACAAAT
    12651 TCTAGAAAAT ACAAACTAAT CTGTAAGGAC AGGAATCAGA TCAGCGGTTG
    12701 CCTGGGAATG AAAATGTGTT TGCAGTGGCA GGGAAAAAGG AATTGTAAAA
    12751 GAGCAGGAAG AAAGTTTTTT TGTTGTTTTT TTTTTGTTTT TTCTTGAGAC
    12801 AGAGTCTTAG TCTATCGCCC AAGCTGGAGT GCAATGGCAC GATCTCAGCT
    12851 CATTGCAACC TCTGCCTCTC GGGTTCAAGC GTTTTTCCTG CCCCAGCCTC
    12901 CCAAGTAGCT GGGATTACAC ATGCGCACCA CCACACTCAG CTAATTTTTG
    12951 TATTTTTAGT AGAGACGGGG TTTTACCATG TTGGCCAGGC TGGTCTCGAA
    13001 CTCCTGACCT CAGGTGATCC ACCCGCCTTG GCCTCCCAAA GTGCTGGGAT
    13051 TACAGGAGTG AGCCACCATG CCTGGCCAGG ACGAAAGTTT TGGGGATGAT
    13101 GGATGGATGT TCCTTATGTT GATTGTGGTG ACGATTCAAT AAGTTATGAT
    13151 CAGAACTTAT CAAAACATTC ACTTTAAATG TGTGCAGTTT ATTTTATGTC
    13201 AGTTATGCCT CAGTTAAGCT GGACAGATGT AGAGGAGGAA GGGAGGGAGA
    13251 GAGGGGGCTG AGATCAGGAC CAAAAGCCAG AGAGAAAGAG ACTGAGAATG
    13301 AGATGAGAGA GAAATGGTAT TTAGACAGAA GACAGGCGAT AGATGATTGA
    13351 TAGTTGACAG ATGATTGGTG GATANNNNNN NNNNNNNNNN NNNNNNNNNN
    13401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    13451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
    13501 AGGAGGTTTA AACAAAACGC AATTATGTTG AAATGACAAT GATTGTGGAT
    13551 ATAAAGGTAG ATAGAAATAG ATATTTGTGA AGATAATGGT TAGATAAAAA
    13601 TGATAGGTAA CAGATATTGA TAGATCTTGA TAAGTAGATG ATAAATACAT
    13651 GATTGATGGA TGACAGGTGA TTGATAGATG ATTTGATGGA TTATAAATAG
    13701 GAGATGATTG AGAGGTGAGA GATAATTGAT GGTTATTTGA TTGGTAGATA
    13751 ATTGATTGAC AGGTTGATAA ATATTGATAG CTAGATGATA GATAAATAGA
    13801 TCATTGGTAG ATATGTGATA TATTGATAAA GAAATTCAGA GGCAAAAGGA
    13851 GAGAGAAATG AAGGGGATAT CGGAGGGGGA AAAATTTTTT TAAACCGAGA
    13901 GTGAAACAAG GAGACAGAAG AAAAGAAAGT GGTGAAAAGA GGAAAAGAAC
    13951 TGAGGGAGAA ATTAAATGAA ACAATGAAGG GAGACAGAGG AAGCATAAGG
    Exon C8
    14001 CCTCTGGCTT TGGCCATATT CTCACCCCTG TGGTCTCCTC TCCCTGGACG
    14051 GCTGACCAGT CCATTCTCAC GCCTCCTCCT CACCCTCATA GGTGACCACC
    14101 CGCCGGCGGA AGAAGGAAGG AGAATACAAC GTCCAGCAAC AGTGCCCAGG
    14151 CTACTACCAG TCACACCTAG ACCTGGAGGA TCTGCAATGA CTGGAACTTG
    14201 CCGGTGCCTG GGGTGCCTTT CCCCCAGCCA GGGTCCAAAG AAGCTTGGCT
    14251 GGGGCAGAAA TAAACCATAT TGGTCGG
  • [0056]
    TABLE 4
    Human cDNA of CA125
    (SEQ ID NO:4)
    1 AAGCGTTGCA CAATTCCCCC AACCTCCATA CATACGGCAG CTCTTCTAGA
    51 CACAGGTTTT CCCAGGTCAA ATGCGGGGAC CCCAGCCATA TCTCCCACCC
    101 TGAGAAATTT TGGAGTTTCA GGGAGCTCAG AAGCTCTGCA GAGGCCACCC
    151 TCTCTGAGGG GATTCTTCTT AGACCTCCAT CCAGAGGCAA ATGTTGACCT
    201 GTCCATGCTG AAACCCTCAG GCCTTCCTGG GTCATCTTCT CCCACCCGCT
    251 CCTTGATGAC AGGGAGCAGG AGCACTAAAG CCACACCAGA AATGGATTCA
    301 GGACTGACAG GAGCCACCTT GTCACCTAAG ACATCTACAG GTGCAATCGT
    351 GGTGACAGAA CATACTCTGC CCTTTACTTC CCCAGATAAG ACCTTGGCCA
    401 GTCCTACATC TTCGGTTGTG GGAAGAACCA CCCAGTCTTT GGGGGTGATG
    451 TCCTCTGCTC TCCCTGAGTC AACCTCTAGA GGAATGACAC ACTCCGAGCA
    501 AAGAACCAGC CCATCGCTGA GTCCCCAGGT CAATGGAACT CCCTCTAGGA
    551 ACTACCCTGC TACAAGCATG GTTTCAGGAT TGAGTTCCCC AAGGACCAGG
    601 ACCAGTTCCA CAGAAGGAAA TTTTACCAAA GAAGCATCTA CATACACACT
    651 CACTGTAGAG ACCACAAGTG GCCCAGTCAC TGAGAAGTAC ACAGTCCCCA
    701 CTGAGACCTC AACAACTGAA GGTGACAGCA CAGAGACCCC CTGGGACACA
    751 AGATATATTC CTGTAAAAAT CACATCTCCA ATGAAAACAT TTGCAGATTC
    801 AACTGCATCC AAGGAAAATG CCCCAGTGTC TATGACTCCA GCTGAGACCA
    851 CAGTTACTGA CTCACATACT CCAGGAAGGA CAAACCCATC ATTTGGGACA
    901 CTTTATTCTT CCTTCCTTGA CCTATCACCT AAAGGGACCC CAAATTCCAG
    951 AGGTGAAACA AGCCTGGAAC TGATTCTATC AACCACTGGA TATCCCTTCT
    1001 CCTCTCCTGA ACCTGGCTCT GCAGGACACA GCAGAATAAG TACCAGTGCG
    1051 CCTTTGTCAT CATCTGCTTC AGTTCTCGAT AATAAAATAT CAGAGACCAG
    1101 CATATTCTCA GGCCAGAGTC TCACCTCCCC TCTGTCTCCT GGGGTGCCCG
    1151 AGGCCAGAGC CAGCACAATG CCCAACTCAG CTATCCCTTT TTCCATGACA
    1201 CTAAGCAATG CAGAAACAAG TGCCGAAAGG GTCAGAAGCA CAATTTCCTC
    1251 TCTGGGGACT CCATCAATAT CCACAAAGCA GACAGCAGAG ACTATCCTTA
    1301 CCTTCCATGC CTTCGCTGAG ACCATGGATA TACCCAGCAC CCACATAGCC
    1351 AAGACTTTGG CTTCAGAATG GTTGGGAAGT CCAGGTACCC TTGGTGGCAC
    1401 CAGCACTTCA GCGCTGACAA CCACATCTCC ATCTACCACT TTAGTCTCAG
    1451 AGGAGACCAA CACCCATCAC TCCACGAGTG GAAAGGAAAC AGAAGGAACT
    1501 TTGAATACAT CTATGACTCC ACTTGAGACC TCTGCTCCTG GAGAAGAGTC
    1551 CGAAATGACT GCCACCTTGG TCCCCACTCT AGGTTTTACA ACTCTTGACA
    1601 GCAAGATCAG AAGTCCATCT CAGGTCTCTT CATCCCACCC AACAAGAGAG
    1651 CTCAGAACCA CAGGCAGCAC CTCTGGGAGG CAGAGTTCCA GCACAGCTGC
    1701 CCACGGGAGC TCTGACATCC TGAGGGCAAC CACTTCCAGC ACCTCAAAAG
    1751 CATCATCATG GACCAGTGAA AGCACAGCTC AGCAATTTAG TGAACCCCAG
    1801 CACACACAGT GGGTGGAGAC AAGTCCTAGC ATGAAAACAG AGAGACCCCC
    1851 AGCATCAACC AGTGTGGCAG CCCCTATCAC CACTTCTGTT CCCTCAGTGG
    1901 TCTCTGGCTT CACCACCCTG AAGACCAGCT CCACAAAAGG GATTTGGCTT
    1951 GAAGAAACAT CTGCAGACAC ACTCATCGGA GAATCCACAG CTGGCCCAAC
    2001 CACCCATCAG TTTGCTGTTC CCACTGGGAT TTCAATGACA GGAGGCAGCA
    2051 GCACCAGGGG AAGCCAGGGC ACAACCCACC TACTCACCAG AGCCACAGCA
    2101 TCATCTGAGA CATCCGCAGA TTTGACTCTG GCCACGAACG GTGTCCCAGT
    2151 CTCCGTGTCT CCAGCAGTGA GCAAGACGGC TGCTGGCTCA AGTCCTCCAG
    2201 GAGGGACAAA GCCATCATAT ACAATGGTTT CTTCTGTCAT CCCTGAGACA
    2251 TCATCTCTAC AGTCCTCAGC TTTCAGGGAA GGAACCAGCC TGGGACTGAC
    2301 TCCATTAAAC ACTAGACATC CCTTCTCTTC CCCTGAACCA GACTCTGCAG
    2351 GACACACCAA GATAAGCACC AGCATTCCTC TGTTGTCATC TGCTTCAGTT
    2401 CTTGAGGATA AAGTGTCAGC GACCAGCACA TTCTCACACC ACAAAGCCAC
    2451 CTCATCTATT ACCACAGGGA CTCCTGAAAT CTCAACAAAG ACAAAGCCCA
    2501 GCTCAGCCGT TCTTTCCTCC ATGACCCTAA GCAATGCAGC AACAAGTCCT
    2551 GAAAGAGTCA GAAATGCAAC TTCCCCTCTG ACTCATCCAT CTCCATCAGG
    2601 GGAAGAGACA GCAGGGAGTG TCCTCACTCT CAGCACCTCT GCTGAGACTA
    2651 CAGACTCACC TAACATCCAC CCAACTGGGA CACTGACTTC AGAATCGTCA
    2701 GAGAGTCCTA GCACTCTCAG CCTCCCAAGT GTCTCTGGAG TCAAAACCAC
    2751 ATTTTCTTCA TCTACTCCTT CCACTCATCT ATTTACTAGT GGAGAAGAAA
    2801 CAGAGGAAAC TTCGAATCCA TCTGTGTCTC AACCTGAGAC TTCTGTTTCC
    2851 AGAGTAAGGA CCACCTTGGC CAGCACCTCT GTCCCTACCC CAGTATTCCC
    2901 CACCATGGAC ACCTGGCCTA CACGTTCAGC TCAGTTCTCT TCATCCCACC
    2951 TAGTGAGTGA GCTCAGAGCT ACGAGCAGTA CCTCAGTTAC AAACTCAACT
    3001 GGTTCAGCTC TTCCTAAAAT ATCTCACCTC ACTGGGACGG CAACAATGTC
    3051 ACAGACCAAT AGAGACACGT TTAATGACTC TGCTGCACCC CAAAGCACAA
    3101 CTTGGCCAGA GACTAGTCCC AGATTCAAGA CAGGGTTACC TTCAGCAACA
    3151 ACCACTGTTT CAACCTCTGC CACTTCTCTC TCTGCTACTG TAATGGTCTC
    3201 TAAATTCACT TCTCCAGCAA CTAGTTCCAT GGAAGCAACT TCTATCAGGG
    3251 AACCATCAAC AACCATCCTC ACAACAGAGA CCACGAATGG CCCAGGCTCT
    3301 ATGGCTGTGG CTTCTACCAA CATCCCAATT GGAAAGGGCT ACATTACTGA
    3351 AGGAAGATTG GACACAAGCC ATCTGCCCAT TGGAACCACA GCTTCCTCTG
    3401 AGACATCTAT GGATTTTACC ATGGCCAAAG AAAGTGTCTC AATGTCAGTA
    3451 TCTCCATCTC AGTCCATGGA TGCTGCTGGC TCAAGCACTC CAGGAAGGAC
    3501 AAGCCAATTC GTTGACACAT TTTCTGATGA TGTCTATCAT TTAACATCCA
    3551 GAGAAATTAC AATACCTAGA GATGGAACAA GCTCAGCTCT GACTCCACAA
    3601 ATGACTGCAA CTCACCCTCC ATCTCCTGAT CCTGGCTCTG CTAGAAGCAC
    3651 CTGGCTTGGC ATCTTGTCCT CATCTCCTTC TTCTCCTACT CCCAAAGTCA
    3701 CAATGAGCTC CACATTTTCA ACTCAGAGAG TCACCACAAG CATGATAATG
    3751 GACACAGTTG AAACTAGTCG GTGGAACATG CCCAACTTAC CTTCCACGAC
    3801 TTCCCTGACA CCAAGTAATA TTCCAACAAG TGGTGCCATA GGAAAAAGCA
    3851 CCCTGGTTCC CTTGGACACT CCATCTCCAG CCACATCATT GGAGGCATCA
    3901 GAAGGGGGAC TTCCAACCCT CAGCACCTAC CCTGAATCAA CAAACACACC
    3951 CAGCATCCAC CTCGGAGCAC ACGCTAGTTC AGAAAGTCCA AGCACCATCA
    4001 AACTTACCAT GGCTTCAGTA GTAAAACCTG GCTCTTACAC ACCTCTCACC
    4051 TTCCCCTCAA TAGAGACCCA CATTCATGTA TCAACAGCCA GAATGGCTTA
    4101 CTCTTCTGGG TCTTCACCTG AGATGACAGC TCCTGGAGAG ACTAACACTG
    4151 GTAGTACCTG GGACCCCACC ACCTACATCA CCACTACGGA TCCTAAGGAT
    4201 ACAAGTTCAG CTCAGGTCTC TACACCCCAC TCAGTGAGGA CACTCAGAAC
    4251 CACAGAAAAC CATCCAAAGA CAGAGTCCGC CACCCCAGCT GCTTACTCTG
    4301 GAAGTCCTAA AATCTCAAGT TCACCCAATC TCACCAGTCC GGCCACAAAA
    4351 GCATGGACCA TCACAGACAC AACTGAACAC TCCACTCAAT TACATTACAC
    4401 AAAATTGGCA GAAAAATCAT CTGGATTTGA GACACAGTCA GCTCCAGGAC
    4451 CTGTCTCTGT AGTAATCCCT ACCTCCCCTA CCATTGGAAG CAGCACATTG
    4501 GAACTAACTT CTGATGTCCC AGGGGAACCC CTGGTCCTTG CTCCCAGTGA
    4551 GCAGACCACA ATCACTCTCC CCATGGCAAC ATGGCTGAGT ACCAGTTTGA
    4601 CAGAGGAAAT GGCTTCAACA GACCTTGATA TTTCAAGTCC AAGTTCACCC
    4651 ATGAGTACAT TTGCTATTTT TCCACCTATG TCCACACCTT CTCATGAACT
    4701 TTCAAAGTCA GAGGCAGATA CCAGTGCCAT TAGAAATACA GATTCAACAA
    4751 CGTTGGATCA GCACCTAGGA ATCAGGAGTT TGGGCAGAAC TGGGGACTTA
    4801 ACAACTGTTC CTATCACCCC ACTGACAACC ACGTGGACCA GTGTGATTGA
    4851 ACACTCAACA CAAGCACAGG ACACCCTTTC TGCAACGATG AGTCCTACTC
    4901 ACGTGACACA GTCACTCAAA GATCAAACAT CTATACCAGC CTCAGCATCC
    4951 CCTTCCCATC TTACTGAAGT CTACCCTGAG CTCGGGACAC AAGGGAGAAG
    5001 CTCCTCTGAG GCAACCACTT TTTGGAAACC ATCTACAGAC ACACTGTCCA
    5051 GAGAGATTGA GACTGGCCCA ACAAACATTC AATCCACTCC ACCCATGGAC
    5101 AACACAACAA CAGGGAGCAG TAGTAGTGGA GTCACCCTGG GCATAGCCCA
    5151 CCTTCCCATA GGAACATCCT CCCCAGCTGA GACATCCACA AACATGGCAC
    5201 TGGAAAGAAG AAGTTCTACA GCCACTGTCT CTATGGCTGG GACAATGGGA
    5251 CTCCTTGTTA CTAGTGCTCC AGGAAGAAGC ATCAGCCAGT CATTAGGAAG
    5301 AGTTTCCTCT GTCCTTTCTG AGTCAACTAC TGAAGGAGTC ACAGATTCTA
    5351 GTAAGGGAAG CAGCCCAAGG CTGAACACAC AGGGAAATAC AGCTCTCTCC
    5401 TCCTCTCTTG AACCCAGCTA TGCTGAAGGA AGCCAGATGA GCACAAGCAT
    5451 CCCTCTAACC TCATCTCCTA CAACTCCTGA TGTGGAATTC ATAGGGGGCA
    5501 GCACATTTTG GACCAAGGAG GTCACCACAG TTATGACCTC AGACATCTCC
    5551 AAGTCTTCAG CAAGGACAGA GTCCAGCTCA GCTACCCTTA TGTCCACAGC
    5601 TTTGGGAAGC ACTGAAAATA CAGGAAAAGA AAAACTCAGA ACTGCCTCTA
    5651 TGGATCTTCC ATCTCCAACT CCATCAATGG AGGTGACACC ATGGATTTCT
    5701 CTCACTCTCA GTAATGCCCC CAATACCACA GATTCACTTG ACCTCAGCCA
    5751 TGGGGTGCAC ACCAGCTCTG CAGGGACTTT GGCCACTGAC AGGTCATTGA
    5801 ATACTGGTGT CACTAGAGCC TCCAGATTGG AAAACGGCTC TGATACCTCT
    5851 TCTAAGTCCC TGTCTATGGG AAACAGCACT CACACTTCCA TGACTGACAC
    5901 AGAGAAGAGT GAAGTGTCTT CTTCAATCCA TCCCCGACCT GAGACCTCAG
    5951 CTCCTGGAGC AGAGACCACT TTGACTTCCA CTCCTGGAAA CAGGGCCATA
    6001 AGCTTAACAT TGCCTTTTTC ATCCATTCCA GTGGAAGAAG TCATTTCTAC
    6051 AGGCATAACC TCAGGACCAG ACATCAACTC AGCACCCATG ACACATTCTC
    6101 CCATCACCCC ACCAACAATT GTATGGACCA GTACAGGCAC AATTGAACAG
    6151 TCCACTCAAC CACTACATGC AGTTTCTTCA GAAAAAGTTT CTGTGCAGAC
    6201 ACAGTCAACT CCATATGTCA ACTCTGTGGC AGTGTCTGCT TCCCCTACCC
    6251 ATGAGAATTC AGTCTCTTCT GGAAGCAGCA CATCCTCTCC ATATTCCTCA
    6301 GCCTCACTTG AATCCTTGGA TTCCACAATC AGTAGGAGGA ATGCAATCAC
    6351 TTCCTGGCTA TGGGACCTCA CTACATCTCT CCCCACTACA ACTTGGCCAA
    6401 GTACTAGTTT ATCTGAGGCA CTGTCCTCAG GCCATTCTGG GGTTTCAAAC
    6451 CCAAGTTCAA CTACGACTGA ATTTCCACTC TTTTCAGCTG CATCCACATC
    6501 TGCTGCTAAG CAAAGAAATC CAGAAACAGA GACCCATGGT CCCCAGAATA
    6551 CAGCCGCGAG TACTTTGAAC ACTGATGCAT CCTCGGTCAC AGGTCTTTCT
    6601 GAGACTCCTG TGGGGGCAAG TATCAGCTCT GAAGTCCCTC TTCCAATGGC
    6651 CATAACTTCT AGATCAGATG TTTCTGGCCT TACATCTGAG AGTACTGCTA
    6701 ACCCGAGTTT AGGCACAGCC TCTTCAGCAG GGACCAAATT AACTAGGACA
    6751 ATATCCCTGC CCACTTCAGA GTCTTTGGTT TCCTTTAGAA TGAACAAGGA
    6801 TCCATGGACA GTGTCAATCC CTTTGGGGTC CCATCCAACT ACTAATACAG
    6851 AAACAAGCAT CCCAGTAAAC AGCGCAGGTC CACCTGGCTT GTCCACAGTA
    6901 GCATCAGATG TAATTGACAC ACCTTCAGAT GGGGCTGAGA GTATTCCCAC
    6951 TGTCTCCTTT TCCCCCTCCC CTGATACTGA AGTGACAACT ATCTCACATT
    7001 TCCCAGAAAA GACAACTCAT TCATTTAGAA CCATTTCATC TCTCACTCAT
    7051 GAGTTGACTT CAAGAGTGAC ACCTATTCCT GGGGATTGGA TGAGTTCAGC
    7101 TATGTCTACA AAGCCCACAG GAGCCAGTCC CTCCATTACA CTGGGAGAGA
    7151 GAAGGACAAT CACCTCTGCT GCTCCAACCA CTTCCCCCAT AGTTCTCACT
    7201 GCTAGTTTCA CAGAGACCAG CACAGTTTCA CTGGATAATG AAACTACAGT
    7251 AAAAACCTCA GATATCCTTG ACGCACGGAA AACAAATGAG CTCCCCTCAG
    7301 ATAGCAGTTC TTCTTCTGAT CTGATCAACA CCTCCATAGC TTCTTCAACT
    7351 ATGGATGTCA CTAAAACAGC CTCCATCAGT CCCACTAGCA TCTCAGGAAT
    7401 GACAGCAAGT TCCTCCCCAT CTCTCTTCTC TTCAGATAGA CCCCAGGTTC
    7451 CCACATCTAC AACAGAGACA AATACAGCCA CCTCTCCATC TGTTTCCAGT
    7501 AACACCTATT CTCTTGATGG GGGCTCCAAT GTGGGTGGCA CTCCATCCAC
    7551 TTTACCACCC TTTACAATCA CCCACCCTGT CGAGACAAGC TCGGCCCTAT
    7601 TAGCCTGGTC TAGACCAGTA AGAACTTTCA GCACCATGGT CAGCACTGAC
    7651 ACTGCCTCCG GAGAAAATCC TACCTCTAGC AATTCTGTGG TGACTTCTGT
    7701 TCCAGCACCA GGTACATGGG CCAGTGTAGG CAGTACTACT GACTTACCTG
    7751 CCATGGGCTT TCTCAAGACA AGTCCTGCAG GAGAGGCACA CTCACTTCTA
    7801 GCATCAACTA TTGAACCAGC CACTGCCTTC ACTCCCCATC TCTCAGCAGC
    7851 AGTGGTCACT GGATCCAGTG CTACATCAGA AGCCAGTCTT CTCACTACGA
    7901 GTGAAAGCAA AGCCATTCAT TCTTCACCAC AGACCCCAAC TACACCCACC
    7951 TCTGGAGCAA ACTGGGAAAC TTCAGCTACT CCTGAGAGCC TTTTGGTAGT
    8001 CACTGAGACT TCAGACACAA CACTTACCTC AAAGATTTTG GTCACAGATA
    8051 CCATCTTGTT TTCAACTGTG TCCACGCCAC CTTCTAAATT TCCAAGTACG
    8101 GGGACTCTGT CTGGAGCTTC CTTCCCTACT TTACTCCCGG ACACTCCAGC
    8151 CATCCCTCTC ACTGCCACTG AGCCAACAAG TTCATTAGCT ACATCCTTTG
    8201 ATTCCACCCC ACTGGTGACT ATAGCTTCGG ATAGTCTTGG CACAGTCCCA
    8251 GAGACTACCC TGACCATGTC AGAGACCTCA AATGGTGATG CACTGGTTCT
    8301 TAAGACAGTA AGTAACCCAG ATAGGAGCAT CCCTGGAATC ACTATCCAAG
    8351 GAGTAACAGA AAGTCCACTC CATCCTTCTT CCACTTCCCC CTCTAAGATT
    8401 GTTGCTCCAC GGAATACAAC CTATGAAGGT TCGATCACAG TGGCACTTTC
    8451 TACTTTGCCT GCGGGAACTA CTGGTTCCCT TGTATTCAGT CAGAGTTCTG
    8501 AAAACTCAGA GACAACGGCT TTGGTAGACT CATCAGCTGG GCTTGAGAGG
    8551 GCATCTGTGA TGCCACTAAC CACAGGAAGC CAGGGTATGG CTAGCTCTGG
    8601 AGGAATCAGA AGTGGGTCCA CTCACTCAAC TGGAACCAAA ACATTTTCTT
    8651 CTCTCCCTCT GACCATGAAC CCAGGTGAGG TTACAGCCAT GTCTGAAATC
    8701 ACCACGAACA GACTGACAGC TACTCAATCA ACAGCACCCA AAGGGATACC
    8751 TGTGAAGCCC ACCAGTGCTG AGTCAGGCCT CCTAACACCT GTCTCTGCCT
    8801 CCTCAAGCCC ATCAAAGGCC TTTGCCTCAC TGACTACAGC TCCCCCATCA
    8851 ACTTGGGGGA TCCCACAGTC TACCTTGACA TTTGAGTTTT CTGAGGTCCC
    8901 AAGTTTGGAT ACTAAGTCCG CTTCTTTACC AACTCCTGGA CAGTCCCTGA
    8951 ACACCATTCC AGACTCAGAT GCAAGCACAG CATCTTCCTC ACTGTCCAAG
    9001 TCTCCAGAAA AAAACCCAAG GGCAAGGATG ATGACTTCCA CAAAGGCCAT
    9051 AAGTGCAAGC TCATTTCAAT CAACAGGTTT TACTGAAACC CCTGAGGGAT
    9101 CTGCCTCCCC TTCTATGGCA GGGCATGAAC CCAGAGTCCC CACTTCAGGA
    9151 ACAGGGGACC CTAGATATGC CTCAGAGAGC ATGTCTTATC CAGACCCAAG
    9201 CAAGGCATCA TCAGCTATGA CATCGACCTC TCTTGCATCA AAACTCACAA
    9251 CTCTCTTCAG CACAGGTCAA GCAGCAAGGT CTGGTTCTAG TTCCTCTCCC
    9301 ATAAGCCTAT CCACTGAGAA AGAAACAAGC TTCCTTTCCC CCACTGCATC
    9351 CACCTCCAGA AAGACTTCAC TATTTCTTGG GCCTTCCATG GCAAGGCAGC
    9401 CCAACATATT GGTGCATCTT CAGACTTCAG CTCTGACACT TTCTCCAACA
    9451 TCCACTCTAA ATATGTCCCA GGAGGAGCCT CCTGAGTTAA CCTCAAGCCA
    9501 GACCATTGCA GAAGAAGAGG GAACAACAGC TGAAACACAG ACGTTAACCT
    9551 TCACACCATC TGAGACCCCA ACATCCTTGT TACCTGTCTC TTCTCCCACA
    9601 GAACCCACAG CCAGAAGAAA GAGTTCTCCA GAAACATGGG CAAGCTCTAT
    9651 TTCAGTTCCT GCCAAGACCT CCTTGGTTGA AACAACTGAT GGAACGCTAG
    9701 TGACCACCAT AAAGATGTCA AGCCAGGCAG CACAAGGAAA TTCCACGTGG
    9751 CCTGCCCCAG CAGAGGAGAC GGGGACCAGT CCAGCAGGCA CATCCCCAGG
    9801 AAGCCCAGAA GTGTCTACCA CTCTCAAAAT CATGAGCTCC AAGGAACCCA
    9851 GCATCAGCCC AGAGATCAGG TCCACTGTGC GAAATTCTCC TTGGAAGACT
    9901 CCAGAAACAA CTGTTCCCAT GGAGACCACA GTGGAACCAG TCACCCTTCA
    9951 GTCCACAGCC CTAGGAAGTG GCAGCACCAG CATCTCTCAC CTGCCCACAG
    10001 GAACCACATC ACCAACCAAG TCACCAACAG AAAATATGTT GGCTACAGAA
    10051 AGGGTCTCCC TCTCCCCATC CCCACCTGAG GCTTGGACCA ACCTTTATTC
    10101 TGGAACTCCA GGAGGGACCA GGCAGTCACT GGCCACAATG TCCTCTGTCT
    10151 CCCTAGAGTC ACCAACTGCT AGAAGCATCA CAGGGACTGG TCAGCAAAGC
    10201 AGTCCAGAAC TGGTTTCAAA GACAACTGGA ATGGAATTCT CTATGTGGCA
    10251 TGGCTCTACT GGAGGGACCA CAGGGGACAC ACATGTCTCT CTGAGCACAT
    10301 CTTCCAATAT CCTTGAAGAC CCTGTAACCA GCCCAAACTC TGTGAGCTCA
    10351 TTGACAGATA AATCCAAACA TAAAACCGAG ACATGGGTAA GCACCACAGC
    10401 CATTCCCTCC ACTGTCCTGA ATAATAAGAT AATGGCAGCT GAACAACAGA
    10451 CAAGTCGATC TGTGGATGAG GCTTATTCAT CAACTAGTTC TTGGTCAGAT
    10501 CAGACATCTG GGAGTGACAT CACCCTTGGT GCATCTCCTG ATGTCACAAA
    10551 CACATTATAC ATCACCTCCA CAGCACAAAC CACCTCACTA GTGTCTCTGC
    10601 CCTCTGGAGA CCAAGGCATT ACAAGCCTCA CCAATCCCTC AGGAGGAAAA
    10651 ACAAGCTCTG CGTCATCTGT CACATCTCCT TCAATAGGGC TTGAGACTCT
    10701 GAGGGCCAAT GTAAGTGCAG TGAAAAGTGA CATTGCCCCT ACTGCTGGGC
    10751 ATCTATCTCA GACTTCATCT CCTGCGGAAG TGAGCATCCT GGACGTAACC
    10801 ACAGCTCCTA CTCCAGGTAT CTCCACCACC ATCACCACCA TGGGAACCAA
    10851 CTCAATCTCA ACTACCACAC CCAACCCAGA AGTGGGTATG AGTACCATGG
    10901 ACAGCACCCC GGCCACAGAG AGGCGCACAA CTTCTACAGA ACACCCTTCC
    10951 ACCTGGTCTT CCACAGCTGC ATCAGATTCC TGGACTGTCA CAGACATGAC
    11001 TTCAAACTTG AAAGTTGCAA GATCTCCTGG AACAATTTCC ACAATGCATA
    11051 CAACTTCATT CTTAGCCTCA AGCACTGAAT TAGACTCCAT GTCTACTCCC
    11101 CATGGCCGTA TAACTGTCAT TGGAACCAGC CTGGTCACTC CATCCTCTGA
    11151 TGCTTCAGCT GTAAAGACAG AGACCAGTAC AAGTGAAAGA ACATTGAGTC
    11201 CTTCAGACAC AACTGCATCT ACTCCCATCT CAACTTTTTC TCGTGTCCAG
    11251 AGGATGAGCA TCTCAGTTCC TGACATTTTA AGTACAAGTT GGACTCCCAG
    11301 TAGTACAGAA GCAGAAGATG TGCCTGTTTC AATGGTTTCT ACAGATCATG
    11351 CTAGTACAAA GACTGACCCA AATACGCCCC TGTCCACTTT TCTGTTTGAT
    11401 TCTCTGTCCA CTCTTGACTG GGACACTGGG AGATCTCTGT CATCAGCCAC
    11451 AGCCACTACC TCAGCTCCTC AGGGGGCCAC AACTCCCCAG GAACTCACTT
    11501 TGGAAACCAT GATCAGCCCA GCTACCTCAC AGTTGCCCTT CTCTATAGGG
    11551 CACATTACAA GTGCAGTCAC ACCAGCTGCA ATGGCAAGGA GCTCTGGAGT
    11601 TACTTTTTCA AGACCAGATC CCACAAGCAA AAAGGCAGAG CAGACTTCCA
    11651 CTCAGCTTCC CACCACCACT TCTGCACATC CAGGGCAGGT GCCCAGATCA
    11701 GCAGCAACAA CTCTGGATGT GATCCCACAC ACAGCAAAAA CTCCAGATGC
    11751 AACTTTTCAG AGACAAGGGC AGACAGCTCT TACAACAGAG GCAAGAGCTA
    11801 CATCTGACTC CTGGAATGAG AAAGAAAAAT CAACCCCAAG TGCACCTTGG
    11851 ATCACTGAGA TGATGAATTC TGTCTCAGAA GATACCATCA AGGAGGTTAC
    11901 CAGCTCCTCC AGTGTATTAA AGGACCCTGA ATACGCTGGA CATAAACTTG
    11951 GAATCTGGGA CGACTTCATC CCCAAGTTTG GAAAAGCAGC CCATATGAGA
    12001 GAGTTGCCCC TTCTGAGTCC ACCACAGGAC AAAGAGGCAA TTCACCCTTC
    12051 TACAAACACA GTAGAGACCA CAGGCTGGGT CACAAGTTCC GAACATGCTT
    12101 CTCATTCCAC TATCCCAGCC CACTCAGCGT CATCCAAACT CACATCTCCA
    12151 GTGGTTACAA CCTCCACCAG GGAACAAGCA ATAGTTTCTA TGTCAACAAC
    12201 CACATGGCCA GAGTCTACAA GGGCTAGAAC AGAGCCTAAT TCCTTCTTGA
    12251 CTATTGAACT GAGGGACGTC AGCCCTTACA TGGACACCAG CTCAACCACA
    12301 CAAACAAGTA TTATCTCTTC CCCAGGTTCC ACTGCGATCA CCAAGGGGCC
    12351 TAGAACAGAA ATTACCTCCT CTAAGAGAAT ATCCAGCTCA TTCCTTGCCC
    12401 AGTCTATGAG GTCGTCAGAC AGCCCCTCAG AAGCCATCAC CAGGCTGTCT
    12451 AACTTTCCTG CCATGACAGA ATCTGGAGGA ATGATCCTTG CTATGCAAAC
    12501 AAGTCCACCT GGCGCTACAT CACTAAGTGC ACCTACTTTG GATACATCAG
    12551 CCACAGCCTC CTGGACAGGG ACTCCACTGG CTACGACTCA GAGATTTACA
    12601 TACTCAGAGA AGACCACTCT CTTTAGCAAA GGTCCTGAGG ATACATCACA
    12651 GCCAAGCCCT CCCTCTGTGG AAGAAACCAG CTCTTCCTCT TCCCTGGTAC
    12701 CTATCCATGC TACAACCTCG CCTTCCAATA TTTTGTTGAC ATCACAAGGG
    12751 CACAGTCCCT CCTCTACTCC ACCTGTGACC TCAGTTTTCT TGTCTGAGAC
    12801 CTCTGGCCTG GGGAAGACCA CAGACATGTC GAGGATAAGC TTGGAACCTG
    12851 GCACAAGTTT ACCTCCCAAT TTGAGCAGTA CAGCAGGTGA GGCGTTATCC
    12901 ACTTATGAAG CCTCCAGAGA TACAAAGGCA ATTCATCATT CTGCAGACAC
    12951 AGCAGTGACG AATATGGAGG CAACCAGTTC TGAATATTCT CCTATCCCAG
    13001 GCCATACAAA GCCATCCAAA GCCACATCTC CATTGGTTAC CTCCCACATC
    13051 ATGGGGGACA TCACTTCTTC CACATCAGTA TTTGGCTCCT CCGAGACCAC
    13101 AGAGATTGAG ACAGTGTCCT CTGTGAACCA GGGACTTCAG GAGAGAAGCA
    13151 CATCCCAGGT GGCCAGCTCT GCTACAGAGA CAAGCACTGT CATTACCCAT
    13201 GTGTCTAGTG GTGATGCTAC TACTCATGTC ACCAAGACAC AAGCCACTTT
    13251 CTCTAGCGGA ACATCCATCT CAAGCCCTCA TCAGTTTATA ACTTCTACCA
    13301 ACACATTTAC AGATGTGAGC ACCAACCCCT CCACCTCTCT GATAATGACA
    13351 GAATCTTCAG GAGTGACCAT CACCACCCAA ACAGGTCCTA CTGGAGCTGC
    13401 AACACAGGGT CCATATCTCT TGGACACATC AACCATGCCT TACTTGACAG
    13451 AGACTCCATT AGCTGTGACT CCAGATTTTA TGCAATCAGA GAAGACCACT
    13501 CTCATAAGCA AAGGTCCCAA GGATGTGACC TGGACAAGCC CTCCCTCTGT
    13551 GGCAGAAACC AGCTATCCCT CTTCCCTGAC ACCTTTCTTG GTCACAACCA
    13601 TACCTCCTGC CACTTCCACG TTACAAGGGC AACATACATC CTCTCCTGTT
    13651 TCTGCGACTT CAGTTCTTAC CTCTGGACTG GTGAAGACCA CAGATATGTT
    13701 GAACACAAGC ATGGAACCTG TGACCAATTC ACCTCAAAAT TTGAACAATC
    13751 CATCAAATGA GATACTGGCC ACTTTGGCAG CCACCACAGA TATAGAGACT
    13801 ATTCATCCTT CCATAAACAA AGCAGTGACC AATATGGGGA CTGCCAGTTC
    13851 AGCACATGTA CTGCATTCCA CTCTCCCAGT CAGCTCAGAA CCATCTACAG
    13901 CCACATCTCC AATGGTTCCT GCCTCCAGCA TGGGGGACGC TCTTGCTTCT
    13951 ATATCAATAC CTGGTTCTGA GACCACAGAC ATTGAGGGAG AGCCAACATC
    14001 CTCCCTGACT GCTGGACGAA AAGAGAACAG CACCCTCCAG GAGATGAACT
    14051 CAACTACAGA GTCAAACATC ATCCTCTCCA ATGTGTCTGT GGGGGCTATT
    14101 ACTGAAGCCA CAAAAATGGA AGTCCCCTCT TTTGATGCAA CATTCATACC
    14151 AACTCCTGCT CAGTCAACAA AGTTCCCAGA TATTTTCTCA GTAGCCAGCA
    14201 GTAGACTTTC AAACTCTCCT CCCATGACAA TATCTACCCA CATGACCACC
    14251 ACCCAGACAG GGTCTTCTGG AGCTACATCA AAGATTCCAC TTGCCTTAGA
    14301 CACATCAACC TTGGAAACCT CAGCAGGGAC TCCATCAGTG GTGACTGAGG
    14351 GGTTTGCCCA CTCAAAAATA ACCACTGCAA TGAACAATGA TGTCAAGGAC
    14401 GTGTCACAGA CAAACCCTCC CTTTCAGGAT GAAGCCAGCT CTCCCTCTTC
    14451 TCAAGCACCT GTCCTTGTCA CAACCTTACC TTCTTCTGTT GCTTTCACAC
    14501 CGCAATGGCA CAGTACCTCC TCTCCTGTTT CTATGTCCTC AGTTCTTACT
    14551 TCTTCACTGG TAAAGACCGC AGGCAAGGTG GATACAAGCT TAGAAACAGT
    14601 GACCAGTTCA CCTCAAAGTA TGAGCAACAC TTTGGATGAC ATATCGGTCA
    14651 CTTCAGCAGC CACCACAGAT ATAGAGACAA CGCATCCTTC CATAAACACA
    14701 GTAGTTACCA ATGTGGGGAC CACCGGTTCA GCATTTGAAT CACATTCTAC
    14751 TGTCTCAGCT TACCCAGAGC CATCTAAAGT CACATCTCCA AATGTTACCA
    14801 CCTCCACCAT GGAAGACACC ACAATTTCCC GATCAATACC TAAATCCTCT
    14851 AAGACTACAA GAACTGAGAC TGAGACAACT TCCTCCCTGA CTCCTAAACT
    14901 GAGGGAGACC AGCATCTCCC AGGAGATCAC CTCGTCCACA GAGACAAGCA
    14951 CTGTTCCTTA CAAAGAGCTC ACTGGTGCCA CTACCGAGGT ATCCAGGACA
    15001 GATGTCACTT CCTCTAGCAG TACATCCTTC CCTGGCCCTG ATCAGTCCAC
    15051 AGTGTCACTA GACATCTCCA CAGAAACCAA CACCAGGCTG TCTACCTCCC
    15101 CAATAATGAC AGAATCTGCA GAAATAACCA TCACCACCCA AACAGGTCCT
    15151 CATGGGGCTA CATCACAGGA TACTTTTACC ATGGACCCAT CAAATACAAC
    15201 CCCCCAGGCA GGGATCCACT CAGCTATGAC TCATGGATTT TCACAATTGG
    15251 ATGTGACCAC TCTTATGAGC AGAATTCCAC AGGATGTATC ATGGACAAGT
    15301 CCTCCCTCTG TGGATAAAAC CAGCTCCCCC TCTTCCTTTC TGTCCTCACC
    15351 TGCAATGACC ACACCTTCCC TGATTTCTTC TACCTTACCA GAGGATAAGC
    15401 TCTCCTCTCC TATGACTTCA CTTCTCACCT CTGGCCTAGT GAAGATTACA
    15451 GACATATTAC GTACACGCTT GGAACCTGTG ACCAGCTCAC TTCCAAATTT
    15501 CAGCAGCACC TCAGATAAGA TACTGGCCAC TTCTAAAGAC AGTAAAGACA
    15551 CAAAGGAAAT TTTTCCTTCT ATAAACACAG AAGAGACCAA TGTGAAAGCC
    15601 AACAACTCTG GACATGAATC CCATTCCCCT GCACTGGCTG ACTCAGAGAC
    15651 ACCCAAAGCC ACAACTCAAA TGGTTATCAC CACCACTGTG GGAGATCCAG
    15701 CTCCTTCCAC ATCAATGCCA GTGCATGGTT CCTCTGAGAC TACAAACATT
    15751 AAGAGAGAGC CAACATATTT CTTGACTCCT AGACTGAGAG AGACCAGTAC
    15801 CTCTCAGGAG TCCAGCTTTC CCACGGACAC AAGTTTTCTA CTTTCCAAAG
    15851 TCCCCACTGG TACTATTACT GAGGTCTCCA GTACAGGGGT CAACTCTTCT
    15901 AGCAAAATTT CCACCCCAGA CCATGATAAG TCCACAGTGC CACCTGACAC
    15951 CTTCACAGGA GAGATCCCCA GGGTCTTCAC CTCCTCTATT AAGACAAAAT
    16001 CTGCAGAAAT GACGATCACC ACCCAAGCAA GTCCTCCTGA GTCTGCATCG
    16051 CACAGTACCC TTCCCTTGGA CACATCAACC ACACTTTCCC AGGGAGGGAC
    16101 TCATTCAACT GTGACTCAGG GATTCCCATA CTCAGAGGTG ACCACTCTCA
    16151 TGGGCATGGG TCCTGGGAAT GTGTCATGGA TGACAACTCC CCCTGTGGAA
    16201 GAAACCAGCT CTGTGTCTTC CCTGATGTCT TCACCTGCCA TGACATCCCC
    16251 TTCTCCTGTT TCCTCCACAT CACCACAGAG CATCCCCTCC TCTCCTCTTC
    16301 CTGTGACTGC ACTTCCTACT TCTGTTCTGG TGACAACCAC AGATGTGTTG
    16351 GGCACAACAA GCCCAGAGTC TGTAACCAGT TCACCTCCAA ATTTGAGCAG
    16401 CATCACTCAT GAGAGACCGG CCACTTACAA AGACACTGCA CACACAGAAG
    16451 CCGCCATGCA TCATTCCACA AACACCGCAG TGACCAATGT AGGGACTTCC
    16501 GGGTCTGGAC ATAAATCACA ATCCTCTGTC CTAGCTGACT CAGAGACATC
    16551 GAAAGCCACA CCTCTGATGA GTACCACCTC CACCCTGGGG GACACAAGTG
    16601 TTTCCACATC AACTCCTAAT ATCTCTCAGA CTAACCAAAT TCAAACAGAG
    16651 CCAACAGCAT CCCTGAGCCC TAGACTGAGG GAGAGCAGCA CGTCTGAGAA
    16701 GACCAGCTCA ACAACAGAGA CAAATACTGC CTTTTCTTAT GTGCCCACAG
    16751 GTGCTATTAC TCAGGCCTCC AGAACAGAAA TCTCCTCTAG CAGAACATCC
    16801 ATCTCAGACC TTGATCGGCC CACAATAGCA CCCGACATCT CCACAGGAAT
    16851 GATCACCAGG CTCTTCACCT CCCCCATCAT GACAAAATCT GCAGAAATGA
    16901 CCGTCACCAC TCAAACAACT ACTCCTGGGG CTACATCACA GGGTATCCTT
    16951 CCTTGGGACA CATCAACCAC ACTTTTCCAG GGAGGGACTC ATTCAACCGT
    17001 GTCTCAGGGA TTCCCACACT CAGAGATAAC CACTCTTCGG AGCAGAACCC
    17051 CTGGAGATGT GTCATGGATG ACAACTCCCC CTGTGGAAGA AACCAGCTCT
    17101 GGGTTTTCCC TGATGTCACC TTCCATGACA TCCCCTTCTC CTGTTTCCTC
    17151 CACATCACCA GAGAGCATCC CCTCCTCTCC TCTCCCTGTG ACTGCACTTC
    17201 TTACTTCTGT TCTGGTGACA ACCACCAATG TATTGGGCAC AACAAGCCCA
    17251 GAGACCGTAA CGAGTTCACC TCCAAATTTA AGCAGCCCCA CACAGGAGAG
    17301 ACTGACCACT TACAAAGACA CTGCGCACAC AGAAGCCATG CATGCTTCCA
    17351 TGCATACAAA CACTGCAGTG GCCAACGTCG GGACCTCCAT TTCTGGACAT
    17401 GAATCACAAT CTTCTGTCCC AGCTGATTCA CACACATCCA AAGCCACATC
    17451 TCCAATGGGT ATCACCTTCG CCATGGGGGA TACAAGTGTT TCTACATCAA
    17501 CTCCTGCCTT CTTTGAGACT AGAATTCAGA CTGAATCAAC ATCCTCTTTG
    17551 ATTCCTGGAT TAAGGGACAC CAGGACGTCT GAGGAGATCA ACACTGTGAC
    11761 AGAGACCAGC ACTGTCCTTT CAGAAGTGCC CACTACTACT ACTACTGAGG
    17651 TCTCCAGGAC AGAAGTTATC ACTTCCAGCA GAACAACCAT CTCAGGGCCT
    17701 GATCATTCCA AAATGTCACC CTACATCTCC ACAGAAACCA TCACCAGGCT
    17751 CTCCACTTTT CCTTTTGTAA CAGGATCCAC AGAAATGGCC ATCACCAACC
    17801 AAACAGGTCC TATAGGGACT ATCTCACAGG CTACCCTTAC CCTGGACACA
    17851 TCAAGCACAG CTTCCTGGGA AGGGACTCAC TCACCTGTGA CTCAGAGATT
    17901 TCCACACTCA GAGGAGACCA CTACTATGAG CAGAAGTACT AAGGGCGTGT
    17951 CATGGCAAAG CCCTCCCTCT GTGGAAGAAA CCAGTTCTCC TTCTTCCCCA
    18001 GTGCCTTTAC CTGCAATAAC CTCACATTCA TCTCTTTATT CCGCAGTATC
    18051 AGGAAGTAGC CCCACTTCTG CTCTCCCTGT GACTTCCCTT CTCACCTCTG
    18101 GCAGGAGGAA GACCATAGAC ATGTTGGACA CACACTCAGA ACTTGTGACC
    18151 AGCTCCTTAC CAAGTGCAAG TAGCTTCTCA GGTGAGATAC TCACTTCTGA
    18201 AGCCTCCACA AATACAGAGA CAATTCACTT TTCAGAGAAC ACAGCAGAAA
    18251 CCAATATGGG GACCACCAAT TCTATGCATA AACTACATTC CTCTGTCTCA
    18301 ATCCACTCCC AGCCATCCGG ACACACACCT CCAAAGGTTA CTGGATCTAT
    18351 GATGGAGGAC GCTATTGTTT CCACATCAAC ACCTGGTTCT CCTGAGACTA
    18401 AAAATGTTGA CAGAGACTCA ACATCCCCTC TGACTCCTGA ACTGAAAGAG
    18451 GACAGCACCG CCCTGGTGAT GAACTCAACT ACAGAGTCAA ACACTGTTTT
    18501 CTCCAGTGTG TCCCTGGATG CTGCTACTGA GGTCTCCAGG GCAGAAGTCA
    18551 CCTACTATGA TCCTACATTC ATGCCAGCTT CTGCTCAGTC AACAAAGTCC
    18601 CCAGACATTT CACCTGAAGC CAGCAGCAGT CATTCTAACT CTCCTCCCTT
    18651 GACAATATCT ACACACAAGA CCATCGCCAC ACAAACAGGT CCTTCTGGGG
    18701 TGACATCTCT TGGCCAACTG ACCCTGGACA CATCAACCAT AGCCACCTCA
    18751 GCAGGAACTC CATCAGCCAG AACTCAGGAT TTTGTAGATT CAGAAACAAC
    18801 CAGTGTCATG AACAATGATC TCAATGATGT GTTGAAGACA AGCCCTTTCT
    18851 CTGCAGAAGA AGCCAACTCT CTCTCTTCTC AGGCACCTCT CCTTGTGACA
    18901 ACCTCACCTT CTCCTGTAAC TTCCACATTG CAAGAGCACA GTACCTCCTC
    18951 TCTTGTTTCT GTGACCTCAG TACCCACCCC TACACTGGCG AAGATCACAG
    19001 ACATGGACAC AAACTTAGAA CCTGTGACTC GTTCACCTCA AAATTTAAGG
    19051 AACACCTTGG CCACTTCAGA AGCCACCACA GATACACACA CAATGCATCC
    19101 TTCTATAAAC ACAGCAATGG CCAATGTGGG GACCACCAGT TCACCAAATG
    19151 AATTCTATTT TACTGTCTCA CCTGACTCAG ACCCATATAA AGCCACATCC
    19201 GCAGTAGTTA TCACTTCCAC CTCGGGGGAC TCAATAGTTT CCACATCAAT
    19251 GCCTAGATCC TCTGCGATGA AAAAGATTGA GTCTGAGACA ACTTTCTCCC
    19301 TGATATTTAG ACTGAGGGAG ACTAGCACCT CCCAGAAAAT TGGCTCATCC
    19351 TCAGACACAA GCACGGTCTT TGACAAAGCA TTCACTGCTG CTACTACTGA
    19401 GGTCTCCAGA ACAGAACTCA CCTCCTCTAG CAGAACATCC ATCCAAGGCA
    19451 CTGAAAAGCC CACAATGTCA CCGGACACCT CCACAAGATC TGTCACCATG
    19501 CTTTCTACTT TTGCTGGCCT GACAAAATCC GAAGAAAGGA CCATTGCCAC
    19551 CCAAACAGGT CCTCATAGGG CGACATCACA GGGTACCCTT ACCTGGGACA
    19601 CATCAATCAC AACCTCACAG GCAGGGACCC ACTCAGCTAT GACTCATGGA
    19651 TTTTCACAAT TAGATTTGTC CACTCTTACG AGTAGAGTTC CTGAGTACAT
    19701 ATCAGGGACA AGCCCACCCT CTGTGGAAAA AACCAGCTCT TCCTCTTCCC
    19751 TTCTGTCTTT ACCAGCAATA ACCTCACCGT CCCCTGTACC TACTACATTA
    19801 CCAGAAAGTA GGCCGTCTTC TCCTGTTCAT CTGACTTCAC TCCCCACCTC
    19851 TGGCCTAGTG AAGACCACAG ATATGCTGGC ATCTGTGGCC AGTTTACCTC
    19901 CAAACTTGGG CAGCACCTCA CATAAGATAC CGACTACTTC AGAAGACATT
    19951 AAAGATACAG AGAAAATGTA TCCTTCCACA AACATAGCAG TAACCAATGT
    20001 GGGGACCACC ACTTCTGAAA AGGAATCTTA TTCGTCTGTC CCAGCCTACT
    20051 CAGAACCACC CAAAGTCACC TCTCCAATGG TTACCTCTTT CAACATAAGG
    20101 GACACCATTG TTTCCACATC CATGCCTGGC TCCTCTGAGA TTACAAGGAT
    20151 TGAGATGGAG TCAACATTCT CCGTGGCTCA TGGGCTGAAG GGAACCAGCA
    20201 CCTCCCAGGA CCCCATCGTA TCCACAGAGA AAAGTGCTGT CCTTCACAAG
    20251 TTGACCACTG GTGCTACTGA GACCTCTAGG ACAGAAGTTG CCTCTTCTAG
    20301 AAGATCATCC ATTCCAGGCC CTGATCATTC CACAGAGTCA CCAGACATCT
    20351 CCACTGAAGT GATCCCCAGC CTGCCTATCT CCCTTGGCAT TACAGAATCT
    20401 TCAAATATGA CCATCATCAC TCGAACAGGT CCTCCTCTTG GCTCTACATC
    20451 ACAGGGCACA TTTACCTTGG ACACACCAAC TACATCCTCC AGGGCAGGAA
    20501 CACACTCGAT GGCGACTCAG GAATTTCCAC ACTCAGAAAT GACCACTGTC
    20551 ATGAACAAGG ACCCTGAGAT TCTATCATGG ACAATCCCTC CTTCTATAGA
    20601 GAAAACCAGC TTCTCCTCTT CCCTGATGCC TTCACCAGCC ATGACTTCAC
    20651 CTCCTGTTTC CTCAACATTA CCAAAGACCA TTCACACCAC TCCTTCTCCT
    20701 ATGACCTCAC TGCTCACCCC TAGCCTAGTG ATGACCACAG ACACATTGGG
    20751 CACAAGCCCA GAACCTACAA CCAGTTCACC TCCAAATTTG AGCAGTACCT
    20801 CACATGTGAT ACTGACAACA GATGAAGACA CCACAGCTAT AGAAGCCATG
    20851 CATCCTTCCA CAAGCACAGC AGCGACTAAT GTGGAAACCA CCTGTTCTGG
    20901 ACATGGGTCA CAATCCTCTG TCCTAACTGA CTCAGAAAAA ACCAAGGCCA
    20951 CAGCTCCAAT GGATACCACC TCCACCATGG GGCATACAAC TGTTTCCACA
    21001 TCAATGTCTG TTTCCTCTGA GACTACAAAA ATTAAGAGAG AGTCAACATA
    21051 TTCCTTGACT CCTGGACTGA GAGAGACCAG CATTTCCCAA AATGCCAGCT
    21101 TTTCCACTGA CACAAGTATT GTTCTTTCAG AAGTCCCCAC TGGTACTACT
    21151 GCTGAGGTCT CCAGGACAGA AGTCACCTCC TCTGGTAGAA CATCCATCCC
    21201 TGGCCCTTCT CAGTCCACAG TTTTGCCAGA AATATCCACA AGAACAATGA
    21251 CAAGGCTCTT TGCCTCGCCC ACCATGACAG AATCAGCAGA AATGACCATC
    21301 CCCACTCAAA CAGGTCCTTC TGGGTCTACC TCACAGGATA CCCTTACCTT
    21351 GGACACATCC ACCACAAAGT CCCAGGCAAA GACTCATTCA ACTTTGACTC
    21401 AGAGATTTCC ACACTCAGAG ATGACCACTC TCATGAGCAG AGGTCCTGGA
    21451 GATATGTCAT GGCAAAGCTC TCCCTCTCTG GAAAATCCCA GCTCTCTCCC
    21501 TTCCCTGCTG TCTTTACCTG CCACAACCTC ACCTCCTCCC ATTTCCTCCA
    21551 CATTACCAGT GACTATCTCC TCCTCTCCTC TTCCTGTGAC TTCACTTCTC
    21601 ACCTCTAGCC CGGTAACGAC CACAGACATG TTACACACAA GCCCAGAACT
    21651 TGTAACCAGT TCACCTCCAA AGCTGAGCCA CACTTCAGAT GAGAGACTGA
    21701 CCACTGGCAA GGACACCACA AATACAGAAG CTGTGCATCC TTCCACAAAC
    21751 ACAGCAGCGT CCAATGTGGA GATTCCCAGC TTTGGACATG AATCCCCTTC
    21801 CTCTGCCTTA GCTGACTCAG AGACATCCAA AGCCACATCA CCAATGTTTA
    21851 TTACCTCCAC CCAGGAGGAT ACAACTGTTG CCATATCAAC CCCTCACTTC
    21901 TTGGAGACTA GCAGAATTCA GAAAGAGTCA ATTTCCTCCC TGAGCCCTAA
    21951 ATTGAGGGAG ACAGGCAGTT CTGTGGAGAC AAGCTCAGCC ATAGAGACAA
    22001 GTGCTGTCCT TTCTGAAGTG TCCATTGGTG CTACTACTGA GATCTCCAGG
    22051 ACAGAAGTCA CCTCCTCTAG CAGAACATCC ATCTCTGGTT CTGCTGAGTC
    22101 CACAATGTTG CCAGAAATAT CCACCACAAG AAAAATCATT AAGTTCCCTA
    22151 CTTCCCCCAT CCTGGCAGAA TCATCAGAAA TGACCATCAA GACCCAAACA
    22201 AGTCCTCCTG GGTCTACATC AGAGAGTACC TTTACATTAG ACACATCAAC
    22251 CACTCCCTCC TTGGTAATAA CCCATTCGAC TATGACTCAG AGATTGCCAC
    22301 ACTCAGAGAT AACCACTCTT GTGAGTAGAG GTGCTGGGGA TGTGCCACGG
    22351 CCCAGCTCTC TCCCTGTGGA AGAAACAAGC CCTCCATCTT CCCAGCTGTC
    22401 TTTATCTGCC ATGATCTCAC CTTCTCCTGT TTCTTCCACA TTACCAGCAA
    22451 GTAGCCACTC CTCTTCTGCT TCTGTGACTT CACCTCTCAC ACCAGGCCAA
    22501 GTGAAGACTA CTGAGGTGTT GGACGCAAGT GCAGAACCTG AAACCAGTTC
    22551 ACCTCCAAGT TTGAGCAGCA CCTCAGTTGA AATACTGGCC ACCTCTGAAG
    22601 TCACCACAGA TACGGAGAAA ATTCATCCTT TCCCAAACAC GGCAGTAACC
    22651 AAAGTTGGAA CTTCCAGTTC TGGACATGAA TCCCCTTCCT CTGTCCTACC
    22701 TGACTCAGAG ACAACCAAAG CCACATCGGC AATGGGTACC ATCTCCATTA
    22751 TGGGGGATAC AAGTGTTTCT ACATTAACTC CTGCCTTATC TAACACTAGG
    22801 AAAATTCAGT CAGAGCCAGC TTCCTCACTG ACCACCAGAT TGAGGGAGAC
    22851 CAGCACCTCT GAAGAGACCA GCTTAGCCAC AGAAGCAAAC ACTGTTCTTT
    22901 CTAAAGTGTC CACTGGTGCT ACTACTGAGG TCTCCAGGAC AGAAGCCATC
    22951 TCCTTTAGCA GAACATCCAT GTCAGGCCCT GAGCAGTCCA CAATGTCACA
    23001 AGACATCTCC ATAGGAACCA TCCCCAGGAT TTCTGCCTCC TCTGTCCTGA
    23051 CAGAATCTGC AAAAATGACC ATCACAACCC AAACAGGTCC TTCGGAGTCT
    23101 ACACTAGAAA GTACCCTTAA TTTGAACACA GCAACCACAC CCTCTTGGGT
    23151 GGAAACCCAC TCTATAGTAA TTCAGGGATT TCCACACCCA GAGATGACCA
    23201 CTTCCATGGG CAGAGGTCCT GGAGGTGTGT CATGGCCTAG CCCTCCCTTT
    23251 GTGAAAGAAA CCAGCCCTCC ATCCTCCCCG CTGTCTTTAC CTGCCGTGAC
    23301 CTCACCTCAT CCTGTTTCCA CCACATTCCT AGCACATATC CCCCCCTCTC
    23351 CCCTTCCTGT GACTTCACTT CTCACCTCTG GCCCGGCGAC AACCACAGAT
    23401 ATCTTGGGTA CAAGCACAGA ACCTGGAACC AGTTCATCTT CAAGTTTGAG
    23451 CACCACCTCC CATGAGAGAC TGACCACTTA CAAAGACACT GCACATACAG
    23501 AAGCCGTGCA TCCTTCCACA AACACAGGAG GGACCAATGT GGCAACCACC
    23551 AGCTCTGGAT ATAAATCACA GTCCTCTGTC CTAGCTGACT CATCTCCAAT
    23601 GTGTACCACC TCCACCATGG GGGATACAAG TGTTCTCACA TCAACTCCTG
    23651 CCTTCCTTGA GACTAGGAGG ATTCAGACAG AGCTAGCTTC CTCCCTGACC
    23701 CCTGGATTGA GGGAGTCCAG TGGCTCTGAA GGGACCAGCT CAGGCACCAA
    23751 GATGAGCACT GTCCTCTCTA AAGTGCCCAC TGGTGCTACT ACTGAGATCT
    23801 CCAAGGAAGA CGTCACCTCC ATCCCAGGTC CCGCTCAATC CACAATATCA
    23851 CCAGACATCT CCACAAGAAC CGTCAGCTGG TTCTCTACAT CCCCTGTCAT
    23901 GACAGAATCA GCAGAAATAA CCATGAACAC CCATACAAGT CCTTTAGGGG
    23951 CCACAACACA AGGCACCAGT ACTTTGGCCA CGTCAAGCAC AACCTCTTTG
    24001 ACAATGACAC ACTCAACTAT ATCTCAAGGA TTTTCACACT CACAGATGAG
    24051 CACTCTTATG AGGAGGGGTC CTGAGGATGT ATCATGGATG AGCCCTCCCC
    24101 TTCTGGAAAA AACTAGACCT TCCTTTTCTC TGATGTCTTC ACCAGCCACA
    24151 ACTTCACCTT CTCCTGTTTC CTCCACATTA CCAGAGAGCA TCTCTTCCTC
    24201 TCCTCTTCCT GTGACTTCAC TCCTCACGTC TGGCTTGGCA AAAACTACAG
    24251 ATATGTTGCA CAAAAGCTCA GAACCTGTAA CCAACTCACC TGCAAATTTG
    24301 AGCAGCACCT CAGTTGAAAT ACTGGCCACC TCTGAAGTCA CCACAGATAC
    24351 AGAGAAAACT CATCCTTCTT CAAACAGAAC AGTGACCGAT GTGGGGACCT
    24401 CCAGTTCTGG ACATGAATCC ACTTCCTTTG TCCTAGCTGA CTCACAGACA
    24451 TCCAAAGTCA CATCTCCAAT GGTTATTACC TCCACCATGG AGGATACGAG
    24501 TGTCTCCACA TCAACTCCTG GCTTTTTTGA GACTAGCAGA ATTCAGACAG
    24551 AACCAACATC CTCCCTGACC CTTGGACTGA GAAAGACCAG CAGCTCTGAG
    24601 GGGACCAGCT TAGCCACAGA GATGAGCACT GTCCTTTCTG GAGTGCCCAC
    24651 TGGTGCCACT GCTGAAGTCT CCAGGACAGA AGTCACCTCC TCTAGCAGAA
    24701 CATCCATCTC AGGCTTTGCT CAGCTCACAG TGTCACCAGA GACTTCCACA
    24751 GAAACCATCA CCAGACTCCC TACCTCCAGC ATAATGACAG AATCAGCAGA
    24801 AATGATGATC AAGACACAAA CAGATCCTCC TGGGTCTACA CCAGAGAGTA
    24851 CTCATACTGT GGACATATCA ACAACACCCA ACTGGGTAGA AACCCACTCG
    24901 ACTGTGACTC AGAGATTTTC ACACTCAGAG ATGACCACTC TTGTGAGCAG
    24951 AAGCCCTGGT GATATGTTAT GGCCTAGTCA ATCCTCTGTG GAAGAAACCA
    25001 GCTCTGCCTC TTCCCTGCTG TCTCTGCCTG CCACGACCTC ACCTTCTCCT
    25051 GTTTCCTCTA CATTAGTAGA GGATTTCCCT TCCGCTTCTC TTCCTGTGAC
    25101 TTCTCTTCTC ACCCCTGGCC TGGTGATAAC CACAGACAGG ATGGGCATAA
    25151 GCAGAGAACC TGGAACCAGT TCCACTTCAA ATTTGAGCAG CACCTCCCAT
    25201 GAGAGACTGA CCACTTTGGA AGACACTGTA GATACAGAAG ACATGCAGCC
    25251 TTCCACACAC ACAGCAGTGA CCAACGTGAG GACCTCCATT TCTGGACATG
    25301 AATCACAATC TTCTGTCCTA TCTGACTCAG AGACACCCAA AGCCACATCT
    25351 CCAATGGGTA CCACCTACAC CATGGGGGAA ACGAGTGTTT CCATATCCAC
    25401 TTCTGACTTC TTTGAGACCA GCAGAATTCA GATAGAACCA ACATCCTCCC
    25451 TGACTTCTGG ATTGAGGGAG ACCAGCAGCT CTGAGAGGAT CAGCTCAGCC
    25501 ACAGAGGGAA GCACTGTCCT TTCTGAAGTG CCCAGTGGTG CTACCACTGA
    25551 GGTCTCCAGG ACAGAAGTGA TATCCTCTAG GGGAACATCC ATGTCAGGGC
    25601 CTGATCAGTT CACCATATCA CCAGACATCT CTACTGAAGC GATCACCAGG
    25651 CTTTCTACTT CCCCCATTAT GACAGAATCA GCAGAAAGTG CCATCACTAT
    25701 TGAGACAGGT TCTCCTGGGG CTACATCAGA GGGTACCCTC ACCTTGGACA
    25751 CCTCAACAAC AACCTTTTGG TCAGGGACCC ACTCAACTGC ATCTCCAGGA
    25801 TTTTCACACT CAGAGATGAC CACTCTTATG AGTAGAACTC CTGGAGATGT
    25851 GCCATGGCCG AGCCTTCCCT CTGTGGAAGA AGCCAGCTCT GTCTCTTCCT
    25901 CACTGTCTTC ACCTGCCATG ACCTCAACTT CTTTTTTCTC CGCATTACCA
    25951 GAGAGCATCT CCTCCTCTCC TCATCCTGTG ACTGCACTTC TCACCCTTGG
    26001 CCCAGTGAAG ACCACAGACA TGTTGCGCAC AAGCTCAGAA CCTGAAACCA
    26051 GTTCACCTCC AAATTTGAGC AGCACCTCAG CTGAAATATT AGCCACGTCT
    26101 GAAGTCACCA AAGATAGAGA GAAAATTCAT CCCTCCTCAA ACACACCTGT
    26151 AGTCAATGTA GGGACTGTGA TTTATAAACA TCTATCCCCT TCCTCTGTTT
    26201 TGGCTGACTT AGTGACAACA AAACCCACAT CTCCAATGGC TACCACCTCC
    26251 ACTCTGGGGA ATACAAGTGT TTCCACATCA ACTCCTGCCT TCCCAGAAAC
    26301 TATGATGACA CAGCCAACTT CCTCCCTGAC TTCTGGATTA AGGGAGATCA
    26351 GTACCTCTCA AGAGACCAGC TCAGCAACAG AGAGAAGTGC TTCTCTTTCT
    26401 GGAATGCCCA CTGGTGCTAC TACTAAGGTC TCCAGAACAG AAGCCCTCTC
    26451 CTTAGGCAGA ACATCCACCC CAGGTCCTGC TCAATCCACA ATATCACCAG
    26501 AAATCTCCAC GGAAACCATC ACTAGAATTT CTACTCCCCT CACCACGACA
    26551 GGATCAGCAG AAATGACCAT CACCCCCAAA ACAGGTCATT CTGGGGCATC
    26601 CTCACAAGGT ACCTTTACCT TGGACACATC AAGCAGAGCC TCCTGGCCAG
    26651 GAACTCACTC AGCTGCAACT CACAGATCTC CACACTCAGG GATGACCACT
    26701 CCTATGAGCA GAGGTCCTGA GGATGTGTCA TGGCCAAGCC GCCCATCAGT
    26751 GGAAAAAACT AGCCCTCCAT CTTCCCTGGT GTCTTTATCT GCAGTAACCT
    26801 CACCTTCGCC ACTTTATTCC ACACCATCTG AGAGTAGCCA CTCATCTCCT
    26851 CTCCGGGTGA CTTCTCTTTT CACCCCTGTC ATGATGAAGA CCACAGACAT
    26901 GTTGGACACA AGCTTGGAAC CTGTGACCAC TTCACCTCCC AGTATGAATA
    26951 TCACCTCAGA TGAGAGTCTG GCCACTTCTA AAGCCACCAT GGAGACAGAG
    27001 GCAATTCAGC TTTCAGAAAA CACAGCTGTG ACTCAGATGG GCACCATCAG
    27051 CGCTAGACAA GAATTCTATT CCTCTTATCC AGGCCTCCCA GAGCCATCCA
    27101 AAGTGACATC TCCAGTGGTC ACCTCTTCCA CCATAAAAGA CATTGTTTCT
    27151 ACAACCATAC CTGCTTCCTC TGAGATAACA AGAATTGAGA TGGAGTCAAC
    27201 ATCCACCCTG ACCCCCACAC CAAGGGAGAC CAGCACCTCC CAGGAGATCC
    27251 ACTCAGCCAC AAAGCCAAGC ACTGTTCCTT ACAAGGCACT CACTAGTGCC
    27301 ACGATTGAGG ACTCCATGAC ACAAGTCATG TCCTCTAGCA GAGGACCTAG
    27351 CCCTGATCAG TCCACAATGT CACAAGACAT ATCCAGTGAA GTGATCACCA
    27401 GGCTCTCTAC CTCCCCCATC AAGGCAGAAT CTACAGAAAT GACCATTACC
    27451 ACCCAAACAG GTTCTCCTGG GGCTACATCA AGGGGTACCC TTACCTTGGA
    27501 CACTTCAACA ACTTTTATGT CAGGGACCCA CTCAACTGCA TCTCAAGGAT
    27551 TTTCACACTC ACAGATGACC GCTCTTATGA GTAGAACTCC TGGAGATGTG
    27601 CCATGGCTAA GCCATCCCTC TGTGGAAGAA GCCAGCTCTG CCTCTTTCTC
    27651 ACTGTCTTCA CCTGTCATGA CCTCATCTTC TCCCGTTTCT TCCACATTAC
    27701 CAGACAGCAT CCACTCTTCT TCGCTTCCTG TGACATCACT TCTCACCTCA
    27751 GGGCTGGTGA AGACCACAGA GCTGTTGGGC ACAAGCTCAG AACCTGAAAC
    27801 CAGTTCACCC CCAAATTTGA GCAGCACCTC AGCTGAAATA CTGGCCACCA
    27851 CTGAAGTCAC TACAGATACA GAGAAACTGG AGATGACCAA TGTGGTAACC
    27901 TCAGGTTATA CACATGAATC TCCTTCCTCT GTCCTAGCTG ACTCAGTGAC
    27951 AACAAAGGCC ACATCTTCAA TGGGTATCAC CTACCCCACA GGAGATACAA
    28001 ATGTTCTCAC ATCAACCCCT GCCTTCTCTG ACACCAGTAG GATTCAAACA
    28051 AAGTCAAAGC TCTCACTGAC TCCTGGGTTG ATGGAGACCA GCATCTCTGA
    28101 AGAGACCAGC TCTGCCACAG AAAAAAGCAC TGTCCTTTCT AGTGTGCCCA
    28151 CTGGTGCTAC TACTGAGGTC TCCAGGACAG AAGCCATCTC TTCTAGCAGA
    28201 ACATCCATCC CAGGCCCTGC TCAATCCACA ATGTCATCAG ACACCTCCAT
    28251 GGAAACCATC ACTAGAATTT CTACCCCCCT CACAAGGAAA GAATCAACAG
    28301 ACATGGCCAT CACCCCCAAA ACAGGTCCTT CTGGGGCTAC CTCGCAGGGT
    28351 ACCTTTACCT TGGACTCATC AAGCACAGCC TCCTGGCCAG GAACTCACTC
    28401 AGCTACAACT CAGAGATTTC CACAGTCAGT GGTGACAACT CCTATGAGCA
    28451 GAGGTCCTGA GGATGTGTCA TGGCCAAGCC CGCTGTCTGT GGAAAAAAAC
    28501 AGCCCTCCAT CTTCCCTGGT ATCTTCATCT TCAGTAACCT CACCTTCGCC
    28551 ACTTTATTCC ACACCATCTG GGAGTAGCCA CTCCTCTCCT GTCCCTGTCA
    28601 CTTCTCTTTT CACCTCTATC ATGATGAAGG CCACAGACAT GTTGGATGCA
    28651 AGTTTGGAAC CTGAGACCAC TTCAGCTCCC AATATGAATA TCACCTCAGA
    28701 TGAGAGTCTG GCCACTTCTA AAGCCACCAC GGAGACAGAG GCAATTCACG
    28751 TTTTTGAAAA TACAGCAGCG TCCCATGTGG AAACCACCAG TGCTACAGAG
    28801 GAACTCTATT CCTCTTCCCC AGGCTTCTCA GAGCCAACAA AAGTGATATC
    28851 TCCAGTGGTC ACCTCTTCCT CTATAAGAGA CAACATGGTT TCCACAACAA
    28901 TGCCTGGCTC CTCTGGCATT ACAAGGATTG AGATAGAGTC AATGTCATCT
    28951 CTGACCCCTG GACTGAGGGA GACCAGAACC TCCCAGGACA TCACCTCATC
    29001 CACAGAGACA AGCACTGTCC TTTACAAGAT GTCCTCTGGT GCCACTCCTG
    29051 AGGTCTCCAG GACAGAAGTT ATGCCCTCTA GCAGAACATC CATTCCTGGC
    29101 CCTGCTCAGT CCACAATGTC ACTAGACATC TCCGATGAAG TTGTCACCAG
    29151 GCTGTCTACC TCTCCCATCA TGACAGAATC TGCAGAAATA ACCATCACCA
    29201 CCCAAACAGG TTATTCTCTG GCTACATCCC AGGTTACCCT TCCCTTGGGC
    29251 ACCTCAATGA CCTTTTTGTC AGGGACCCAC TCAACTATGT CTCAAGGACT
    29301 TTCACACTCA GAGATGACCA ATCTTATGAG CAGGGGTCCT GAAAGTCTGT
    29351 CATGGACGAG CCCTCGCTTT GTGGAAACAA CTAGATCTTC CTCTTCTCTG
    29401 ACATCATTAC CTCTCACGAC CTCACTTTCT CCTGTGTCCT CCACATTACT
    29451 AGACAGTAGC CCCTCCTCTC CTCTTCCTGT GACTTCACTT ATCCTCCCAG
    29501 GCCTGGTGAA GACTACAGAA GTGTTGGATA CAAGCTCAGA GCCTAAAACC
    29551 AGTTCATCTC CAAATTTGAG CAGCACCTCA GTTGAAATAC CGGCCACCTC
    29601 TGAAATCATG ACAGATACAG AGAAAATTCA TCCTTCCTCA AACACAGCGG
    29651 TGGCCAAAGT GAGGACCTCC AGTTCTGTTC ATGAATCTCA TTCCTCTGTC
    29701 CTAGCTGACT CAGAAACAAC CATAACCATA CCTTCAATGG GTATCACCTC
    29751 CGCTGTGGAC GATACCACTG TTTTCACATC AAATCCTGCC TTCTCTGAGA
    29801 CTAGGAGGAT TCCGACAGAG CCAACATTCT CATTGACTCC TGGATTCAGG
    29851 GAGACTAGCA CCTCTGAAGA GACCACCTCA ATCACAGAAA CAAGTGCAGT
    29901 CCTTTATGGA GTGCCCACTA GTGCTACTAC TGAAGTCTCC ATGACAGAAA
    29951 TCATGTCCTC TAATAGAACA CACATCCCTG ACTCTGATCA GTCCACGATG
    30001 TCTCCAGACA TCATCACTGA AGTGATCACC AGGCTCTCTT CCTCATCCAT
    30051 GATGTCAGAA TCAACACAAA TGACCATCAC CACCCAAAAA AGTTCTCCTG
    30101 GGGCTACAGC ACAGAGTACT CTTACCTTGG CCACAACAAC AGCCCCCTTG
    30151 GCAAGGACCC ACTCAACTGT TCCTCCTAGA TTTTTACACT CAGAGATGAC
    30201 AACTCTTATG AGTAGGAGTC CTGAAAATCC ATCATGGAAG AGCTCTCCCT
    30251 TTGTGGAAAA AACTAGCTCT TCATCTTCTC TGTTGTCCTT ACCTGTCACG
    30301 ACCTCACCTT CTGTTTCTTC CACATTACCG CAGAGTATCC CTTCCTCCTC
    30351 TTTTTCTGTG ACTTCACTCC TCACCCCAGG CATGGTGAAG ACTACAGACA
    30401 CAAGCACAGA ACCTGGAACC AGTTTATCTC CAAATCTGAG TGGCACCTCA
    30451 GTTGAAATAC TGGCTGCCTC TGAAGTCACC ACAGATACAG AGAAAATTCA
    30501 TCCTTCTTCA AGCATGGCAG TGACCAATGT GGGAACCACC AGTTCTGGAC
    30551 ATGAACTATA TTCCTCTGTT TCAATCCACT CGGAGCCATC CAAGGCTACA
    30601 TACCCAGTGG GTACTCCCTC TTCCATGGCT GAAACCTCTA TTTCCACATC
    30651 AATGCCTGCT AATTTTGAGA CCACAGGATT TGAGGCTGAG CCATTTTCTC
    30701 ATTTGACTTC TGGATTTAGG AAGACAAACA TGTCCCTGGA CACCAGCTCA
    30751 GTCACACCAA CAAATACACC TTCTTCTCCT GGGTCCACTC ACCTTTTACA
    30801 GAGTTCCAAG ACTGATTTCA CCTCTTCTGC AAAAACATCA TCCCCAGACT
    30851 GGCCTCCAGC CTCACAGTAT ACTGAAATTC CAGTGGACAT AATCACCCCC
    30901 TTTAATGCTT CTCCATCTAT TACGGAGTCC ACTGGGATAA CCTCCTTCCC
    30951 AGAATCCAGG TTTACTATGT CTGTAACAGA AAGTACTCAT CATCTGAGTA
    31001 CAGATTTGCT GCCTTCAGCT GAGACTATTT CCACTGGCAC AGTGATGCCT
    31051 TCTCTATCAG AGGCCATGAC TTCATTTGCC ACCACTGGAG TTCCACGAGC
    31101 CATCTCAGGT TCAGGTAGTC CATTCTCTAG GACAGAGTCA GGCCCTGGGG
    31151 ATGCTACTCT GTCCACCATT GCAGAGAGCC TGCCTTCATC CACTCCTGTG
    31201 CCATTCTCCT CTTCAACCTT CACTACCACT GATTCTTCAA CCATCCCAGC
    31251 CCTCCATGAG ATAACTTCCT CTTCAGCTAC CCCATATAGA GTGGACACCA
    31301 GTCTTGGGAC AGAGAGCAGC ACTACTGAAG GACGCTTGGT TATGGTCAGT
    31351 ACTTTGGACA CTTCAAGCCA ACCAGGCAGG ACATCTTCAA CACCCATTTT
    31401 GGATACCAGA ATGACAGAGA GCGTTGAGCT GGGAACAGTG ACAAGTGCTT
    31451 ATCAAGTTCC TTCACTCTCA ACACGGTTGA CAAGAACTGA TGGCATTATG
    31501 GAACACATCA CAAAAATACC CAATGAAGCA GCACACAGAG GTACCATAAG
    31551 ACCAGTCAAA GGCCCTCAGA CATCCACTTC GCCTGCCAGT CCTAAAGGAC
    31601 TACACACAGG AGGGACAAAA AGAATGGAGA CCACCACCAC AGCTTTGAAG
    31651 ACCACCACCA CAGCTTTGAA GACCACTTCC AGAGCCACCT TGACCACCAG
    31701 TGTCTATACT CCCACTTTGG GAACACTGAC TCCCCTCAAT GCATCAAGGC
    31751 AAATGGCCAG CACAATCCTC ACAGAAATGA TGATCACAAC CCCATATGTT
    31801 TTCCCTGATG TTCCAGAAAC GACATCCTCA TTGGCTACCA GCCTGGGAGC
    31851 AGAAACCAGC ACAGCTCTTC CCAGGACAAC CCCATCTGTT CTCAATAGAG
    31901 AATCAGAGAC CACAGCCTCA CTGGTCTCTC GTTCTGGGGC AGAGAGAAGT
    31951 CCGGTTATTC AAACTCTAGA TGTTTCTTCT AGTGAGCCAG ATACAACAGC
    32001 TTCATGGGTT ATCCATCCTG CAGAGACCAT CCCAACTGTT TCCAAGACAA
    32051 CCCCCAATTT TTTCCACAGT GAATTAGACA CTGTATCTTC CACAGCCACC
    32101 AGTCATGGGG CAGACGTCAG CTCAGCCATT CCAACAAATA TCTCACCTAG
    32151 TGAACTAGAT GCACTGACCC CACTGGTCAC TATTTCGGGG ACAGATACTA
    32201 GTACAACATT CCCAACACTG ACTAAGTCCC CACATGAAAC AGAGACAAGA
    32251 ACCACATGGC TCACTCATCC TGCAGAGACC AGCTCAACTA TTCCCAGAAC
    32301 AATCCCCAAT TTTTCTCATC ATGAATCAGA TGCCACACCT TCAATAGCCA
    32351 CCAGTCCTGG GGCAGAAACC AGTTCAGCTA TTCCAATTAT GACTGTCTCA
    32401 CCTGGTGCAG AAGATCTGGT GACCTCACAG GTCACTAGTT CTGGGACAGA
    32451 CAGAAATATG ACTATTCCAA CTTTGACTCT TTCTCCTGGT GAACCAAAGA
    32501 CGATAGCCTC ATTAGTCACC CATCCTGAAG CACAGACAAG TTCGGCCATT
    32551 CCAACTTCAA CTATCTCGCC TGCTGTATCA CGGTTGGTGA CCTCAATGGT
    32601 CACCAGTTTG GCGGCAAAGA CAAGTACAAC TAATCGAGCT CTGACAAACT
    32651 CCCCTGGTGA ACCAGCTACA ACAGTTTCAT TGGTCACGCA TCCTGCACAG
    32701 ACCAGCCCAA CAGTTCCCTG GACAACTTCC ATTTTTTTCC ATAGTAAATC
    32751 AGACACCACA CCTTCAATGA CCACCAGTCA TGGGGCAGAA TCCAGTTCAG
    32801 CTGTTCCAAC TCCAACTGTT TCAACTGAGG TACCAGGAGT AGTGACCCCT
    32851 TTGGTCACCA GTTCTAGGGC AGTGATCAGT ACAACTATTC CAATTCTGAC
    32901 TCTTTCTCCT GGTGAACCAG AGACCACACC TTCAATGGCC ACCAGTCATG
    32951 GGGAAGAAGC CAGTTCTGCT ATTCCAACTC CAACTGTTTC ACCTGGGGTA
    33001 CCAGGAGTGG TGACCTCTCT GGTCACTAGT TCTAGGGCAG TGACTAGTAC
    33051 AACTATTCCA ATTCTGACTT TTTCTCTTGG TGAACCAGAG ACCACACCTT
    33101 CAATGGCCAC CAGTCATGGG ACAGAAGCTG GCTCAGCTGT TCCAACTGTT
    33151 TTACCTGAGG TACCAGGAAT GGTGACCTCT CTGGTTGCTA GTTCTAGGGC
    33201 AGTAACCAGT ACAACTCTTC CAACTCTGAC TCTTTCTCCT GGTGAACCAG
    33251 AGACCACACC TTCAATGGCC ACCAGTCATG GGGCAGAAGC CAGCTCAACT
    33301 GTTCCAACTG TTTCACCTGA GGTACCAGGA GTGGTGACCT CTCTGGTCAC
    33351 TAGTTCTAGT GGAGTAAACA GTACAAGTAT TCCAACTCTG ATTCTTTCTC
    33401 CTGGTGAACT AGAAACCACA CCTTCAATGG CCACCAGTCA TGGGGCAGAA
    33451 GCCAGCTCAG CTGTTCCAAC TCCAACTGTT TCACCTGGGG TATCAGGAGT
    33501 GGTGACCCCT CTGGTCACTA GTTCCAGGGC AGTGACCAGT ACAACTATTC
    33551 CAATTCTAAC TCTTTCTTCT AGTGAGCCAG AGACCACACC TTCAATGGCC
    33601 ACCAGTCATG GGGTAGAAGC CAGCTCAGCT GTTCTAACTG TTTCACCTGA
    33651 GGTACCAGGA ATGGTGACCT CTCTGGTCAC TAGTTCTAGA GCAGTAACCA
    33701 GTACAACTAT TCCAACTCTG ACTATTTCTT CTGATGAACC AGAGACCACA
    33751 ACTTCATTGG TCACCCATTC TGAGGCAAAG ATGATTTCAG CCATTCCAAC
    33801 TTTAGCTGTC TCCCCTACTG TACAAGGGCT GGTGACTTCA CTGGTCACTA
    33851 GTTCTGGGTC AGAGACCAGT GCGTTTTCAA ATCTAACTGT TGCCTCAAGT
    33901 CAACCAGAGA CCATAGACTC ATGGGTCGCT CATCCTGGGA CAGAAGCAAG
    33951 TTCTGTTGTT CCAACTTTGA CTGTCTCCAC TGGTGAGCCG TTTACAAATA
    34001 TCTCATTGGT CACCCATCCT GCAGAGAGTA GCTCAACTCT TCCCAGGACA
    34051 ACCTCAAGGT TTTCCCACAG TGAATTAGAC ACTATGCCTT CTACAGTCAC
    34101 CAGTCCTGAG GCAGAATCCA GCTCAGCCAT TTCAACTACT ATTTCACCTG
    34151 GTATACCAGG TGTGCTGACA TCACTGGTCA CTAGCTCTGG GAGAGACATC
    34201 AGTGCAACTT TTCCAACAGT GCCTGAGTCC CCACATGAAT CAGAGGCAAC
    34251 AGCCTCATGG GTTACTCATC CTGCAGTCAC CAGCACAACA GTTCCCAGGA
    34301 CAACCCCTAA TTATTCTCAT AGTGAACCAG ACACCACACC ATCAATAGCC
    34351 ACCAGTCCTG GGGCAGAAGC CACTTCAGAT TTTCCAACAA TAACTGTCTC
    34401 ACCTGATGTA CCAGATATGG TAACCTCACA GGTCACTAGT TCTGGGACAG
    34451 ACACCAGTAT AACTATTCCA ACTCTGACTC TTTCTTCTGG TGAGCCAGAG
    34501 ACCACAACCT CATTTATCAC CTATTCTGAG ACACACACAA GTTCAGCCAT
    34551 TCCAACTCTC CCTGTCTCCC CTGGTGCATC AAAGATGCTG ACCTCACTGG
    34601 TCATCAGTTC TGGGACAGAC AGCACTACAA CTTTCCCAAC ACTGACGGAG
    34651 ACCCCATATG AACCAGAGAC AACAGCCATA CAGCTCATTC ATCCTGCAGA
    34701 GACCAACACA ATGGTTCCCA AGACAACTCC CAAGTTTTCC CATAGTAAGT
    34751 CAGACACCAC ACTCCCAGTA GCCATCACCA GTCCTGGGCC AGAAGCCAGT
    34801 TCAGCTGTTT CAACGACAAC TATCTCACCT GATATGTCAG ATCTGGTGAC
    34851 CTCACTGGTC CCTAGTTCTG GGACAGACAC CAGTACAACC TTCCCAACAT
    34901 TGAGTGAGAC CCCATATGAA CCAGAGACTA CAGTCACGTG GCTCACTCAT
    34951 CCTGCAGAAA CCAGCACAAC GGTTTCTGGG ACAATTCCCA ACTTTTCCCA
    35001 TAGGGGATCA GACACTGCAC CCTCAATGGT CACCAGTCCT GGAGTAGACA
    35051 CGAGGTCAGG TGTTCCAACT ACAACCATCC CACCCAGTAT ACCAGGGGTA
    35101 GTGACCTCAC AGGTCACTAG TTCTGCAACA GACACTAGTA CAGCTATTCC
    35151 AACTTTGACT CCTTCTCCTG GTGAACCAGA GACCACAGCC TCATCAGCTA
    35201 CCCATCCTGG GACACAGACT GGCTTCACTG TTCCAATTCG GACTGTTCCC
    35251 TCTAGTGAGC CAGATACAAT GGCTTCCTGG GTCACTCATC CTCCACAGAC
    35301 CAGCACACCT GTTTCCAGAA CAACCTCCAG TTTTTCCCAT AGTAGTCCAG
    35351 ATGCCACACC TGTAATGGCC ACCAGTCCTA GGACAGAAGC CAGTTCAGCT
    35401 GTACTGACAA CAATCTCACC TGGTGCACCA GAGATGGTGA CTTCACAGAT
    35451 CACTAGTTCT GGGGCAGCAA CCAGTACAAC TGTTCCAACT TTGACTCATT
    35501 CTCCTGGTAT GCCAGAGACC ACAGCCTTAT TGAGCACCCA TCCCAGAACA
    35551 GGGACAAGTA AAACATTTCC TGCTTCAACT GTGTTTCCTC AAGTATCAGA
    35601 GACCACAGCC TCACTCACCA TTAGACCTGG TGCAGAGACT AGCACAGCTC
    35651 TCCCAACTCA GACAACATCC TCTCTCTTCA CCCTACTTGT AACTGGAACC
    35701 AGCAGAGTTG ATCTAAGTCC AACTGCTTCA CCTGGTGTTT CTGCAAAAAC
    35751 AGCCCCACTT TCCACCCATC CAGGGACAGA GACCAGCACA ATGATTCCAA
    35801 CTTCAACTCT TTCCCTTGGT TTACTAGAGA CTACAGGCTT ACTGGCCACC
    35851 AGCTCTTCAG CAGAGACCAG CACGAGTACT CTAACTCTGA CTGTTTCCCC
    35901 TGCTGTCTCT GGGCTTTCCA GTGCCTCTAT AACAACTGAT AAGCCCCAAA
    35951 CTGTGACCTC CTGGAACACA GAAACCTCAC CATCTGTAAC TTCAGTTGGA
    36001 CCCCCAGAAT TTTCCAGGAC TGTCACAGGC ACCACTATGA CCTTGATACC
    36051 ATCAGAGATG CCAACACCAC CTAAAACCAG TCATGGAGAA GGAGTGAGTC
    36101 CAACCACTAT CTTGAGAACT ACAATGGTTG AAGCCACTAA TTTAGCTACC
    36151 ACAGGTTCCA GTCCCACTGT GGCCAAGACA ACAACCACCT TCAATACACT
    36201 GGCTGGAAGC CTCTTTACTC CTCTGACCAC ACCTGGGATG TCCACCTTGG
    36251 CCTCTGAGAG TGTGACCTCA AGAACAAGTT ATAACCATCG GTCCTGGATC
    36301 TCCACCACCA GCAGTTATAA CCGTCGGTAC TGGACCCCTG CCACCAGCAC
    36351 TCCAGTGACT TCTACATTCT CCCCAGGGAT TTCCACATCC TCCATCCCCA
    36401 GCTCCACAGC AGCCACAGTC CCATTCATGG TGCCATTCAC CCTCAACTTC
    36451 ACCATCACCA ACCTGCAGTA CGAGGAGGAC ATGCGGCACC CTGGTTCCAG
    36501 GAAGTTCAAC GCCACAGAGA GAGAACTGCA GGGTCTGCTC AAACCCTTGT
    36551 TCAGGAATAG CAGTCTGGAA TACCTCTATT CAGGCTGCAG ACTAGCCTCA
    36601 CTCAGGCCAG AGAAGGATAG CTCAGCCATG GCAGTGGATG CCATCTGCAC
    36651 ACATCGCCCT GACCCTGAAG ACCTCGGACT GGACAGAGAG CGACTGTACT
    36701 GGGAGCTGAG CAATCTGACA AATGGCATCC AGGAGCTGGG CCCCTACACC
    36751 CTGGACCGGA ACAGTCTCTA TGTCAATGGT TTCACCCATC GAAGCTCTAT
    36801 GCCCACCACC AGCACTCCTG GGACCTCCAC AGTGGATGTG GGAACCTCAG
    36851 GGACTCCATC CTCCAGCCCC AGCCCCACGG CTGCTGGCCC TCTCCTGATG
    36901 CCGTTCACCC TCAACTTCAC CATCACCAAC CTGCAGTACG AGGAGGACAT
    36951 GCGTCGCACT GGCTCCAGGA AGTTCAACAC CATGGAGAGT GTCCTGCAGG
    37001 GTCTGCTCAA GCCCTTGTTC AAGAACACCA GTGTTGGCCC TCTGTACTCT
    37051 GGCTGCAGAT TGACCTTGCT CAGGCCCGAG AAAGATGGGG CAGCCACTGG
    37101 AGTGGATGCC ATCTGCACCC ACCGCCTTGA CCCCAAAAGC CCTGGACTCA
    37151 ACAGGGAGCA GCTGTACTGG GAGCTAAGCA AACTGACCAA TGACATTGAA
    37201 GAGCTGGGCC CCTACACCCT GGACAGGAAC AGTCTCTATG TCAATGGTTT
    37251 CACCCATCAG AGCTCTGTGT CCACCACCAG CACTCCTGGG ACCTCCACAG
    37301 TGGATCTCAG AACCTCAGGG ACTCCATCCT CCCTCTCCAG CCCCACAATT
    37351 ATGGCTGCTG GCCCTCTCCT GGTACCATTC ACCCTCAACT TCACCATCAC
    37401 CAACCTGCAG TATGGGGAGG ACATGGGTCA CCCTGGCTCC AGGAAGTTCA
    37451 ACACCACAGA GAGGGTCCTG CAGGGTCTGC TTGGTCCCAT ATTCAAGAAC
    37501 ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC AGACTGACCT CTCTCAGGTC
    37551 TGAGAAGGAT GGAGCAGCCA CTGGAGTGGA TGCCATCTGC ATCCATCATC
    37601 TTGACCCCAA AAGCCCTGGA CTCAACAGAG AGCGGCTGTA CTGGGAGCTG
    37651 AGCCAACTGA CCAATGGCAT CAAAGAGCTG GGCCCCTACA CCCTGGACAG
    37701 GAACAGTCTC TATGTCAATG GTTTCACCCA TCGGACCTCT GTGCCCACCA
    37751 CCAGCACTCC TGGGACCTCC ACAGTGGACC TTGGAACCTC AGGGACTCCA
    37801 TTCTCCCTCC CAAGCCCCGC AACTGCTGGC CCTCTCCTGG TGCTGTTCAC
    37851 CCTCAACTTC ACCATCACCA ACCTGAAGTA TGAGGAGGAC ATGCATCGCC
    37901 CTGGCTCCAG GAAGTTCAAC ACCACTGAGA GGGTCCTGCA GACTCTGCTT
    37951 GGTCCTATGT TCAAGAACAC CAGTGTTGGC CTTCTGTACT CTGGCTGCAG
    38001 ACTGACCTTG CTCAGGTCCG AGAAGGATGG AGCAGCCACT GGAGTGGATG
    38051 CCATCTGCAC CCACCGTCTT GACCCCAAAA GCCCTGGACT GGACAGAGAG
    38101 CAGCTATACT GGGAGCTGAG CCAGCTGACC AATGGCATCA AAGAGCTGGG
    38151 CCCCTACACC CTGGACAGGA ACAGTCTCTA TGTCAATGGT TTCACCCATT
    38201 GGATCCCTGT GCCCACCAGC AGCACTCCTG GGACCTCCAC AGTGGACCTT
    38251 GGGTCAGGGA CTCCATCCTC CCTCCCCAGC CCCACAGCTG CTGGCCCTCT
    38301 CCTGGTGCCA TTCACCCTCA ACTTCACCAT CACCAACCTG CAGTACGAGG
    38351 AGGACATGCA TCACCCAGGC TCCAGGAAGT TCAACACCAC GGAGCGGGTC
    38401 CTGCAGGGTC TGCTTGGTCC CATGTTCAAG AACACCAGTG TCGGCCTTCT
    38451 GTACTCTGGC TGCAGACTGA CCTTGCTCAG GTCCGAGAAG GATGGAGCAG
    38501 CCACTGGAGT GGATGCCATC TGCACCCACC GTCTTGACCC CAAAAGCCCT
    38551 GGAGTGGACA GGGAGCAGCT ATACTGGGAG CTGAGCCAGC TGACCAATGG
    38601 CATCAAAGAG CTGGGTCCCT ACACCCTGGA CAGAAACAGT CTCTATGTCA
    38651 ATGGTTTCAC CCATCAGACC TCTGCGCCCA ACACCAGCAC TCCTGGGACC
    38701 TCCACAGTGG ACCTTGGGAC CTCAGGGACT CCATCCTCCC TCCCCAGCCC
    38751 TACATCNGCT GGCCCTCTCC TGGTNCCNTT CACCCTCAAC TTCACCATCA
    38801 CCAACCTGCA GTACGAGGAG GACATGCGGC ACCCNGGNTC CAGGAAGTTC
    38851 AACACCACNG AGAGGGTNCT GCAGGGTCTG CTNAAGCCCC TNTTCAAGAG
    38901 CACCAGTGTT GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGGT
    38951 CCGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CACCCACCGT
    39001 CTTGACCCCA AAAGCCCTGG AGTGGACAGG GAGCAGCTAT ACTGGGAGCT
    39051 GAGCCAGCTG ACCAATGGCA TCAAAGAGCT GGGTCCCTAC ACCCTGGACA
    39101 GAAACAGTCT CTATGTCAAT GGTTTCACCC ATCAGACCTC TGCGCCCAAC
    39151 ACCAGCACTC CTGGGACCTC CACAGTGGAC CTTGGGACCT CAGGGACTCC
    39201 ATCCTCCCTC CCCAGCCCTA CATCTGCTGG CCCTCTCCTG GTGCCATTCA
    39251 CCCTCAACTT CACCATCACC AACCTGCAGT ACGAGGAGGA CATGCATCAC
    39301 CCAGGCTCCA GGAAGTTCAA CACCACGGAG CGGGTCCTGC AGGGTCTGCT
    39351 TGGTCCCATG TTCAAGAACA CCAGTGTCGG CCTTCTGTAC TCTGGCTGCA
    39401 GACTGACCTT GCTCAGGCCT GAGAAGAATG GGGCAGCCAC TGGAATGGAT
    39451 GCCATCTGCA GCCACCGTCT TGACCCCAAA AGCCCTGGAC TCAACAGAGA
    39501 GCAGCTGTAC TGGGAGCTGA GCCAGCTGAC CCATGGCATC AAAGAGCTGG
    39551 GCCCCTACAC CCTGGACAGG AACAGTCTCT ATGTCAATGG TTTCACCCAT
    39601 CGGAGCTCTG TGGCCCCCAC CAGCACTCCT GGGACCTCCA CAGTGGACCT
    39651 TGGGACCTCA GGGACTCCAT CCTCCCTCCC CAGCCCCACA ACAGCTGTTC
    39701 CTCTCCTGGT GCCGTTCACC CTCAACTTTA CCATCACCAA TCTGCAGTAT
    39751 GGGGAGGACA TGCGTCACCC TGGCTCCAGG AAGTTCAACA CCACAGAGAG
    39801 GGTCCTGCAG GGTCTGCTTG GTCCCTTGTT CAAGAACTCC AGTGTCGGCC
    39851 CTCTGTACTC TGGCTGCAGA CTGATCTCTC TCAGGTCTGA GAAGGATGGG
    39901 GCAGCCACTG GAGTGGATGC CATCTGCACC CACCACCTTA ACCCTCAAAG
    39951 CCCTGGACTG GACAGGGAGC AGCTGTACTG GCAGCTGAGC CAGATGACCA
    40001 ATGGCATCAA AGAGCTGGGC CCCTACACCC TGGACCGGAA CAGTCTCTAC
    40051 GTCAATGGTT TCACCCATCG GAGCTCTGGG CTCACCACCA GCACTCCTTG
    40101 GACTTCCACA GTTGACCTTG GAACCTCAGG GACTCCATCC CCCGTCCCCA
    40151 GCCCCACAAC TGCTGGCCCT CTCCTGGTGC CATTCACCCT CAACTTCACC
    40201 ATCACCAACC TGCAGTATGA GGAGGACATG CATCGCCCTG GATCTAGGAA
    40251 GTTCAACACC ACAGAGAGGG TCCTGCAGGG TCTGCTTAGT CCCATTTTCA
    40301 AGAACTCCAG TGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCTCTCTC
    40351 AGGCCCGAGA AGGATGGGGC AGCAACTGGA ATGGATGCTG TCTGCCTCTA
    40401 CCACCCTAAT CCCAAAAGAC CTGGACTGGA CAGAGAGCAG CTGTACTGGG
    40451 AGCTAAGCCA GCTGACCCAC AACATCACTG AGCTGGGCCC CTACAGCCTG
    40501 GACAGGGACA GTCTCTATGT CAATGGTTTC ACCCATCAGA ACTCTGTGCC
    40551 CACCACCAGT ACTCCTGGGA CCTCCACAGT GTACTGGGCA ACCACTGGGA
    40601 CTCCATCCTC CTTCCCCGGC CACACAGAGC CTGGCCCTCT CCTGATACCA
    40651 TTCACTTTCA ACTTTACCAT CACCAACCTG CATTATGAGG AAAACATGCA
    40701 ACACCCTGGT TCCAGGAAGT TCAACACCAC GGAGAGGGTT CTGCAGGGTC
    40751 TGCTCAAGCC CTTGTTCAAG AACACCAGTG TTGGCCCTCT GTACTCTGGC
    40801 TGCAGACTGA CCTCTCTCAG GCCCGAGAAG GATGGGGCAG CAACTGGAAT
    40851 GGATGCTGTC TGCCTCTACC ACCCTAATCC CAAAAGACCT GGGCTGGACA
    40901 GAGAGCAGCT GTACTGGGAG CTAAGCCAGC TGACCCACAA CATCACTGAG
    40951 CTGGGCCCCT ACAGCCTGGA CAGGGACAGT CTCTATGTCA ATGGTTTCAC
    41001 CCATCAGAAC TCTGTGCCCA CCACCAGTAC TCCTGGGACC TCCACAGTGT
    41051 ACTGGGCAAC CACTGGGACT CCATCCTCCT TCCCCGGCCA CACAGAGCCT
    41101 GGCCCTCTCC TGATACCATT CACTTTCAAC TTTACCATCA CCAACCTGCA
    41151 TTATGAGGAA AACATGCAAC ACCCTGGTTC CAGGAAGTTC AACACCACGG
    41201 AGAGGGTTCT GCAGGGTCTG CTCAAGCCCT TGTTCAAGAA CACCAGTGTT
    41251 GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA
    41301 TGAGGCAGCC ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA
    41351 TCGGACCTGG ACTGGACAGG GAGCGGCTAT ACTGGGAGCT GAGCCAGCTG
    41401 ACCAACAGCA TTACCGAACT GGGACCCTAC ACCCTGGACA GGGACAGTCT
    41451 CTATGTCAAT GGCTTCAACC CTCGGAGCTC TGTGCCAACC ACCAGCACTC
    41501 CTGGGACCTC CACAGTGCAC CTGGCAACCT CTGGGACTCC ATCCTCCCTG
    41551 CCTGGCCACA CAGCCCCTGT CCCTCTCTTG ATACCATTCA CCCTCAACTT
    41601 TACCATCACC AACCTGCATT ATGAGGAAAA CATGCAACAC CCTGGTTCCA
    41651 GGAAGTTCAA CACCACGGAG AGGGTTCTGC AGGGTCTGCT CAAGCCCTTG
    41701 TTCAAGAACA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT
    41751 GCTCAGACCT GAGAAGCATG AGGCAGCCAC TGGAGTGGAC ACCATCTGTA
    41801 CCCACCGCGT TGATCCCATC GGACCTGGAC TGNACAGNGA GCNGCTNTAC
    41851 TGGGAGCTNA GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC
    41901 CCTGGACAGG NACAGTCTCT ATGTCAATGG TTTCACCCAT CNGANCTCTG
    41951 NGCCCACCAC CAGCACTCCT GGGACCTCCA CAGTGNACNT NGGNACCTCN
    42001 GGGACTCCAT CCTCCNTCCC CNGCCNCACA TCTGCTGGCC CTCTCCTGGT
    42051 GCCATTCACC CTCAACTTCA CCATCACCAA CCTGCAGTAC GAGGAGGACA
    42101 TGCATCACCC AGGCTCCAGG AAGTTCAACA CCACGGAGCG GGTCCTGCAG
    42151 GGTCTGCTTG GTCCCATGTT CAAGAACACC AGTGTCGGCC TTCTGTACTC
    42201 TGGCTGCAGA CTGACCTTGC TCAGGCCTGA GAAGAATGGG GCAGCCACTG
    42251 GAATGGATGC CATCTGCAGC CACCGTCTTG ACCCCAAAAG CCCTGGACTC
    42301 GACAGAGAGC AGCTGTACTG GGAGCTGAGC CAGCTGACCC ATGGCATCAA
    42351 AGAGCTGGGC CCCTACACCC TGGACAGGAA CAGTCTCTAT GTCAATGGTT
    42401 TCACCCATCG GAGCTCTGTG GCCCCCACCA GCACTCCTGG GACCTCCACA
    42451 GTGGACCTTG GGACCTCAGG GACTCCATCC TCCCTCCCCA GCCCCACAAC
    42501 AGCTGTTCCT CTCCTGGTGC CGTTCACCCT CAACTTTACC ATCACCAATC
    42551 TGCAGTATGG GGAGGACATG CGTCACCCTG GCTCCAGGAA GTTCAACACC
    42601 ACAGAGAGGG TCCTGCAGGG TCTGCTTGGT CCCTTGTTCA AGAACTCCAG
    42651 TGTCGGCCCT CTGTACTCTG GCTGCAGACT GATCTCTCTC AGGTCTGAGA
    42701 AGGATGGGGC AGCCACTGGA GTGGATGCCA TCTGCACCCA CCACCTTAAC
    42751 CCTCAAAGCC CTGGACTGGA CAGGGAGCAG CTGTACTGGC AGCTGAGCCA
    42801 GATGACCAAT GGCATCAAAG AGCTGGGCCC CTACACCCTG GACCGGAACA
    42851 GTCTCTACGT CAATGGTTTC ACCCATCGGA GCTCTGGGCT CACCACCAGC
    42901 ACTCCTTGGA CTTCCACAGT TGACCTTGGA ACCTCAGGGA CTCCATCCCC
    42951 CGTCCCCAGC CCCACAACTG CTGGCCCTCT CCTGGTGCCA TTCACCCTAA
    43001 ACTTCACCAT CACCAACCTG CAGTATGAGG AGGACATGCA TCGCCCTGGA
    43051 TCTAGGAAGT TCAACGCCAC AGAGAGGGTC CTGCAGGGTC TGCTTAGTCC
    43101 CATATTCAAG AACTCCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA
    43151 CCTCTCTCAG GCCCGAGAAG GATGGGGCAG CAACTGGAAT GGATGCTGTC
    43201 TGCCTCTACC ACCCTAATCC CAAAAGACCT GGACTGGACA GAGAGCAGCT
    43251 GTACTGGGAG CTAAGCCAGC TGACCCACAA CATCACTGAG CTGGGCCCCT
    43301 ACAGCCTGGA CAGGGACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAGC
    43351 TCTATGACGA CCACCAGAAC TCCTGATACC TCCACAATGC ACCTGGCAAC
    43401 CTCGAGAACT CCAGCCTCCC TGTCTGGACC TACGACCGCC AGCCCTCTCC
    43451 TGGTGCTATT CACAATCAAC TGCACCATCA CCAACCTGCA GTACGAGGAG
    43501 GACATGCGTC GCACTGGCTC CAGGAAGTTC AACACCATGG AGAGTGTCCT
    43551 GCAGGGTCTG CTCAAGCCCT TGTTCAAGAA CACCAGTGTT GGCCCTCTGT
    43601 ACTCTGGCTG CAGATTGACC TTGCTCAGGC CCAAGAAAGA TGGGGCAGCC
    43651 ACTGGAGTGG ATGCCATCTG CACCCACCGC CTTGACCCCA AAAGCCCTGG
    43701 ACTCAACAGG GAGCAGCTGT ACTGGGAGCT AAGCAAACTG ACCAATGACA
    43751 TTGAAGAGCT GGGCCCCTAC ACCCTGGACA GGAACAGTCT CTATGTCAAT
    43801 GGTTTCACCC ATCAGAGCTC TGTGTCCACC ACCAGCACTC CTGGGACCTC
    43851 CACAGTGGAT CTCAGAACCT CAGGGACTCC ATCCTCCCTC TCCAGCCCCA
    43901 CAATTATGNC NNCTGNCCCT CTCCTGNTNC CNTTCACCNT CAACTTNACC
    43951 ATCACCAACC TGCANTANGN GGANNACATG CNNCNCCCNG GNTCCAGGAA
    44001 GTTCAACACC ACNGAGAGGG TCCTACAGGG TCTGCTCAGG CCCTTGTTCA
    44051 AGAACACCAG TGTCAGCTCT CTGTACTCTG GTTGCAGACT GACCTTGCTC
    44101 AGGCCTGAGA AGGATGGGGC AGCCACCAGA GTGGATGCTG CCTGCACCTA
    44151 CCGCCCTGAT CCCAAAAGCC CTGGACTGGA CAGAGAGCAA CTATACTGGG
    44201 AGCTGAGCCA GCTAACCCAC AGCATCACTG AGCTGGGACC CTACACCCTG
    44251 GACAGGGTCA GTCTCTATGT CAATGGCTTC AACCCTCGGA GCTCTGTGCC
    44301 AACCACCAGC ACTCCTGGGA CCTCCACAGT GCACCTGGCA ACCTCTGGGA
    44351 CTCCATCCTC CCTGCCTGGC CACACANCNN CTGNCCCTCT CCTGNTNCCN
    44401 TTCACCNTCA ACTTNACCAT CACCAACCTG CANTANGNGG ANNACATGCN
    44451 NCNCCCNGGN TCCAGGAAGT TCAACACCAC NGAGAGGGTT CTGCAGGGTC
    44501 TGCTCAAACC CTTGTTCAGG AATAGCAGTC TGGAATACCT CTATTCAGGC
    44551 TGCAGACTAG CCTCACTCAG GCCAGAGAAG GATAGCTCAG CCATGGCAGT
    44601 GGATGCCATC TGCACACATC GCCCTGACCC TGAAGACCTC GGACTGGACA
    44651 GAGAGCGACT GTACTGGGAG CTGAGCAATC TGACAAATGG CATCCAGGAG
    44701 CTGGGCCCCT ACACCCTGGA CCGGAACAGT CTCTACGTCA ATGGTTTCAC
    44751 CCATCGGAGC TCTGGGCTCA CCACCAGCAC TCCTTGGACT TCCACAGTTG
    44801 ACCTTGGAAC CTCAGGGACT CCATCCCCCG TCCCCAGCCC CACAACTGCT
    44851 GGCCCTCTCC TGGTGCCATT CACCCTCAAC TTCACCATCA CCAACCTGCA
    44901 GTATGAGGAG GACATGCATC GCCCTGGTTC CAGGAGGTTC AACACCACGG
    44951 AGAGGGTTCT GCAGGGTCTG CTCACGCCCT TGTTCAAGAA CACCAGTGTT
    45001 GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA
    45051 AGAGGCAGCC ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA
    45101 TCGGACCTGG ACTGGACAGA GAGCGGCTAT ACTGGGAGCT GAGCCAGCTG
    45151 ACCAACAGCA TCACAGAGCT GGGACCCTAC ACCCTGGATA GGGACAGTCT
    45201 CTATGTCAAT GGCTTCAACC CTTGGAGCTC TGTGCCAACC ACCAGCACTC
    45251 CTGGGACCTC CACAGTGCAC CTGGCAACCT CTGGGACTCC ATCCTCCCTG
    45301 CCTGGCCACA CAGCCCCTGT CCCTCTCTTG ATACCATTCA CCCTCAACTT
    45351 TACCATCACC GACCTGCATT ATGAAGAAAA CATGCAACAC CCTGGTTCCA
    45401 GGAAGTTCAA CACCACGGAG AGGGTTCTGC AGGGTCTGCT CAAGCCCTTG
    45451 TTCAAGAGCA CCAGCGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT
    45501 GCTCAGACCT GAGAAACATG GGGCAGCCAC TGGAGTGGAC GCCATCTGCA
    45551 CCCTCCGCCT TGATCCCACT GGTCCTGGAC TGGACAGAGA GCGGCTATAC
    45601 TGGGAGCTGA GCCAGCTGAC CAACAGCGTT ACAGAGCTGG GCCCCTACAC
    45651 CCTGGACAGG GACAGTCTCT ATGTCAATGG CTTCACCCAT CGGAGCTCTG
    45701 TGCCAACCAC CAGTATTCCT GGGACCTCTG CAGTGCACCT GGAAACCTCT
    45751 GGGACTCCAG CCTCCCTCCC TGGCCACACA GCCCCTGGCC CTCTCCTGGT
    45801 GCCATTCACC CTCAACTTCA CTATCACCAA CCTGCAGTAT GAGGAGGACA
    45851 TGCGTCACCC TGGTTCCAGG AAGTTCAGCA CCACGGAGAG AGTCCTGCAG
    45901 GGTCTGCTCA AGCCCTTGTT CAAGAACACC AGTGTCAGCT CTCTGTACTC
    45951 TGGTTGCAGA CTGACCTTGC TCAGGCCTGA GAAGGATGGG GCAGCCACCA
    46001 GAGTGGATGC TGTCTGCACC CATCGTCCTG ACCCCAAAAG CCCTGGACTG
    46051 GACAGAGAGC GGCTGTACTG GAAGCTGAGC CAGCTGACCC ACGGCATCAC
    46101 TGAGCTGGGC CCCTACACCC TGGACAGGCA CAGTCTCTAT GTCAATGGTT
    46151 TCACCCATCA GAGCTCTATG ACGACCACCA GAACTCCTGA TACCTCCACA
    46201 ATGCACCTGG CAACCTCGAG AACTCCAGCC TCCCTGTCTG GACCTACGAC
    46251 CGCCAGCCCT CTCCTGGTGC TATTCACAAT TAACTTCACC ATCACTAACC
    46301 TGCGGTATGA GGAGAACATG CATCACCCTG GCTCTAGAAA GTTTAACACC
    46351 ACGGAGAGAG TCCTTCAGGG TCTGCTCAGG CCTGTGTTCA AGAACACCAG
    46401 TGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCACGCTC AGGCCCAAGA
    46451 AGGATGGGGC AGCCACCAAA GTGGATGCCA TCTGCACCTA CCGCCCTGAT
    46501 CCCAAAAGCC CTGGACTGGA CAGAGAGCAG CTATACTGGG AGCTGAGCCA
    46551 GCTAACCCAC AGCATCACTG AGCTGGGCCC CTACACCCAG GACAGGGACA
    46601 GTCTCTATGT CAATGGCTTC ACCCATCGGA GCTCTGTGCC AACCACCAGT
    46651 ATTCCTGGGA CCTCTGCAGT GCACCTGGAA ACCTCTGGGA CTCCAGCCTC
    46701 CCTCCCTGGC CACACAGCCC CTGGCCCTCT CCTGGTGCCA TTCACCCTCA
    46751 ACTTCACTAT CACCAACCTG CAGTATGAGG AGGACATGCG TCACCCTGGT
    46801 TCCAGGAAGT TCAACACCAC GGAGAGAGTC CTGCAGGGTC TGCTCAAGCC
    46851 CTTGTTCAAG AGCACCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA
    46901 CCTTGCTCAG GCCTGAAAAA CGTGGGGCAG CCACCGGCGT GGACACCATC
    46951 TGCACTCACC GCCTTGACCC TCTAAACCCA GGACTGGACA GAGAGCAGCT
    47001 ATACTGGGAG CTGAGCAAAC TGACCCGTGG CATCATCGAG CTGGGCCCCT
    47051 ACCTCCTGGA CAGAGGCAGT CTCTATGTCA ATGGTTTCAC CCATCGGACC
    47101 TCTGTGCCCA CCACCAGCAC TCCTGGGACC TCCACAGTGG ACCTTGGAAC
    47151 CTCAGGGACT CCATTCTCCC TCCCAAGCCC CGCANCNNCT GNCCCTCTCC
    47201 TGNTNCCNTT CACCNTCAAC TTNACCATCA CCAACCTGCA NTANGNGGAN
    47251 NACATGCNNC NCCCNGGNTC CAGGAAGTTC AACACCACNG AGAGGGTCCT
    47301 GCAGACTCTG CTTGGTCCTA TGTTCAAGAA CACCAGTGTT GGCCTTCTGT
    47351 ACTCTGGCTG CAGACTGACC TTGCTCAGGT CCGAGAAGGA TGGAGCAGCC
    47401 ACTGGAGTGG ATGCCATCTG CACCCACCGT CTTGACCCCA AAAGCCCTGG
    47451 AGTGGACAGG GAGCAACTAT ACTGGGAGCT GAGCCAGCTG ACCAATGGCA
    47501 TTAAAGAACT GGGCCCCTAC ACCCTGGACA GGAACAGTCT CTATGTCAAT
    47551 GGGTTCACCC ATTGGATCCC TGTGCCCACC AGCAGCACTC CTGGGACCTC
    47601 CACAGTGGAC CTTGGGTCAG GGACTCCATC CTCCCTCCCC AGCCCCACAA
    47651 CTGCTGGCCC TCTCCTGGTG CCGTTCACCC TCAACTTCAC CATCACCAAC
    47701 CTGAAGTACG AGGAGGACAT GCATTGCCCT GGCTCCAGGA AGTTCAACAC
    47751 CACAGAGAGA GTCCTGCAGA GTCTGCTTGG TCCCATGTTC AAGAACACCA
    47801 GTGTTGGCCC TCTGTACTCT GGCTGCAGAC TGACCTTGCT CAGGTCCGAG
    47851 AAGGATGGAG CAGCCACTGG AGTGGATGCC ATCTGCACCC ACCGTCTTGA
    47901 CCCCAAAAGC CCTGGAGTGG ACAGGGAGCA GCTATACTGG GAGCTGAGCC
    47951 AGCTGACCAA TGGCATCAAA GAGCTGGGTC CCTACACCCT GGACAGAAAC
    48001 AGTCTCTATG TCAATGGTTT CACCCATCAG ACCTCTGCGC CCAACACCAG
    48051 CACTCCTGGG ACCTCCACAG TGGACCTTGG GACCTCAGGG ACTCCATCCT
    48101 CCCTCCCCAG CCCTACANCN NCTGNCCCTC TCCTGNTNCC NTTCACCNTC
    48151 AACTTNACCA TCACCAACCT GCANTANGNG GANNACATGC NNCNCCCNGG
    48201 NTCCAGGAAG TTCAACACCA CNGAGNGNGT NCTGCAGGGT CTGCTNNNNC
    48251 CCNTNTTCAA GAACNCCAGT GTNGGCCNTC TGTACTCTGG CTGCAGACTG
    48301 ACCTNNCTCA GGNCNGAGAA GNATGGNGCA GCCACTGGAN TGGATGCCAT
    48351 CTGCANCCAC CNNCNTNANC CCAAAAGNCC TGGACTGNAC AGNGAGCNGC
    48401 TNTACTGGGA GCTNAGCCAN CTGACCAANN NCATCNNNGA GCTGGGNCCC
    48451 TACACCCTGG ACAGGNACAG TCTCTATGTC AATGGTTTCA CCCATTGGAT
    48501 CCCTGTGCCC ACCAGCAGCA CTCCTGGGAC CTCCACAGTG GACCTTGGGT
    48551 CAGGGACTCC ATCCTCCCTC CCCAGCCCCA CAACTGCTGG CCCTCTCCTG
    48601 GTGCCGTTCA CCCTCAACTT CACCATCACC AACCTGAAGT ACGAGGAGGA
    48651 CATGCATTGC CCTGGCTCCA GGAAGTTCAA CACCACAGAG AGAGTCCTGC
    48701 AGAGTCTGCT TGGTCCCATG TTCAAGAACA CCAGTGTTGG CCCTCTGTAC
    48751 TCTGGCTGCA GACTGACCTC GCTCAGGTCC GAGAAGGATG GAGCAGCCAC
    48801 TGGAGTGGAT GCCATCTGCA CCCACCGTGT TGACCCCAAA AGCCCTGGAG
    48851 TGGACAGGGA GCAGCTATAC TGGGAGCTGA GCCAGCTGAC CAATGGCATC
    48901 AAAGAGCTGG GTCCCTACAC CCTGGACAGA AACAGTCTCT ATGTCAATGG
    48951 TTTCACCCAT CAGACCTCTG CGCCCAACAC CAGCACTCCT GGGACCTCCA
    49001 CAGTGNACNT NGGNACCTCN GGGACTCCAT CCTCCNTCCC CNGCCNCACA
    49051 TCTGCTGGCC CTCTCCTGGT GCCATTCACC CTCAACTTCA CCATCACCAA
    49101 CCTGCAGTAC GAGGAGGACA TGCATCACCC AGGCTCCAGG AAGTTCAACA
    49151 CCACGGAGCG GGTCCTGCAG GGTCTGCTTG GTCCCATGTT CAAGAACACC
    49201 AGTGTCGGCC TTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGGCCTGA
    49251 GAAGAATGGG GCAACCACTG GAATGGATGC CATCTGCACC CACCGTCTTG
    49301 ACCCCAAAAG CCCTGGACTG NACAGNGAGC NGCTNTACTG GGAGCTNAGC
    49351 CANCTGACCA ANNNCATCNN NGAGCTGGGN CCCTACACCC TGGACAGGNA
    49401 CAGTCTCTAT GTCAATGGTT TCACCCATCN GANCTCTGNG CCCACCACCA
    49451 GCACTCCTGG GACCTCCACA GTGNACNTNG GNACCTCNGG GACTCCATCC
    49501 TCCNTCCCCN GCCNCACANC NNCTGNCCCT CTCCTGNTNC CNTTCACCNT
    49551 CAACTTNACC ATCACCAACC TGCANTANGN GGANNACATG CNNCNCCCNG
    49601 GNTCCAGGAA GTTCAACACC ACNGAGAGGG TTCTGCAGGG TCTGCTCAAA
    49651 CCCTTGTTCA GGAATAGCAG TCTGGAATAC CTCTATTCAG GCTGCAGACT
    49701 AGCCTCACTC AGGCCAGAGA AGGATAGCTC AGCCATGGCA GTGGATGCCA
    49751 TCTGCACACA TCGCCCTGAC CCTGAAGACC TCGGACTGGA CAGAGAGCGA
    49801 CTGTACTGGG AGCTGAGCAA TCTGACAAAT GGCATCCAGG AGCTGGGCCC
    49851 CTACACCCTG GACCGGAACA GTCTCTATGT CAATGGTTTC ACCCATCGAA
    49901 GCTCTATGCC CACCACCAGC ACTCCTGGGA CCTCCACAGT GGATGTGGGA
    49951 ACCTCAGGGA CTCCATCCTC CAGCCCCAGC CCCACGACTG CTGGCCCTCT
    50001 CCTGATACCA TTCACCCTCA ACTTCACCAT CACCAACCTG CAGTATGGGG
    50051 AGGACATGGG TCACCCTGGC TCCAGGAAGT TCAACACCAC AGAGAGGGTC
    50101 CTGCAGGGTC TGCTTGGTCC CATATTCAAG AACACCAGTG TTGGCCCTCT
    50151 GTACTCTGGC TGCAGACTGA CCTCTCTCAG GTCTGAGAAG GATGGAGCAG
    50201 CCACTGGAGT GGATGCCATC TGCATCCATC ATCTTGACCC CAAAAGCCCT
    50251 GGACTCAACA GAGAGCGGCT GTACTGGGAG CTGAGCCAAC TGACCAATGG
    50301 CATCAAAGAG CTGGGCCCCT ACACCCTGGA CAGGAACAGT CTCTATGTCA
    50351 ATGGTTTCAC CCATCGGACC TCTGTGCCCA CCACCAGCAC TCCTGGGACC
    50401 TCCACAGTGG ACCTTGGAAC CTCAGGGACT CCATTCTCCC TCCCAAGCCC
    50451 CGCAACTGCT GGCCCTCTCC TGGTGCTGTT CACCCTCAAC TTCACCATCA
    50501 CCAACCTGAA GTATGAGGAG GACATGCATC GCCCTGGCTC CAGGAAGTTC
    50551 AACACCACTG AGAGGGTCCT GCAGACTCTG CTTGGTCCTA TGTTCAAGAA
    50601 CACCAGTGTT GGCCTTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGGT
    50651 CCGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CACCCACCGT
    50701 CTTGACCCCA AAAGCCCTGG ACTGNACAGN GAGCNGCTNT ACTGGGAGCT
    50751 NAGCCANCTG ACCAANNNCA TCNNNGAGCT GGGNCCCTAC ACCCTGGACA
    50801 GGNACAGTCT CTATGTCAAT GGTTTCACCC ATCNGANCTC TGNGCCCACC
    50851 ACCAGCACTC CTGGGACCTC CACAGTGNAC NTNGGNACCT CNGGGACTCC
    50901 ATCCTCCNTC CCCNGCCNCA CANCNNCTGN CCCTCTCCTG NTNCCNTTCA
    50951 CCNTCAACTT NACCATCACC AACCTGCANT ANGNGGANNA CATGCNNCNC
    51001 CCNGGNTCCA GGAAGTTCAA CACCACNGAG AGAGTCCTTC AGGGTCTGCT
    51051 CAGGCCTGTG TTCAAGAACA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA
    51101 GACTGACCTT GCTCAGGCCC AAGAAGGATG GGGCAGCCAC CAAAGTGGAT
    51151 GCCATCTGCA CCTACCGCCC TGATCCCAAA AGCCCTGGAC TGGACAGAGA
    51201 GCAGCTATAC TGGGAGCTGA GCCAGCTAAC CCACAGCATC ACTGAGCTGG
    51251 GCCCCTACAC CCAGGACAGG GACAGTCTCT ATGTCAATGG CTTCACCCAT
    51301 CGGAGCTCTG TGCCAACCAC CAGTATTCCT GGGACCTCTG CAGTGCACCT
    51351 GGAAACCACT GGGACTCCAT CCTCCTTCCC CGGCCACACA GAGCCTGGCC
    51401 CTCTCCTGAT ACCATTCACT TTCAACTTTA CCATCACCAA CCTGCGTTAT
    51451 GAGGAAAACA TGCAACACCC TGGTTCCAGG AAGTTCAACA CCACGGAGAG
    51501 GGTTCTGCAG GGTCTGCTCA CGCCCTTGTT CAAGAACACC AGTGTTGGCC
    51551 CTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGACCTGA GAAGCAGGAG
    51601 GCAGCCACTG GAGTGGACAC CATCTGTACC CACCGCGTTG ATCCCATCGG
    51651 ACCTGGACTG GACAGAGAGC GGCTATACTG GGAGCTGAGC CAGCTGACCA
    51701 ACAGCATCAC AGAGCTGGGA CCCTACACCC TGGATAGGGA CAGTCTCTAT
    51751 GTCGATGGCT TCAACCCTTG GAGCTCTGTG CCAACCACCA GCACTCCTGG
    51801 GACCTCCACA GTGCACCTGG CAACCTCTGG GACTCCATCC CCCCTGCCTG
    51851 GCCACACAGC CCCTGTCCCT CTCTTGATAC CATTCACCCT CAACTTTACC
    51901 ATCACCGACC TGCATTATGA AGAAAACATG CAACACCCTG GTTCCAGGAA
    51951 GTTCAACACC ACGGAGAGGG TTCTGCAGGG TCTGCTCAAG CCCTTGTTCA
    52001 AGAGCACCAG CGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCTTGCTC
    52051 AGACCTGAGA AACATGGGGC AGCCACTGGA GTGGACGCCA TCTGCACCCT
    52101 CCGCCTTGAT CCCACTGGTC CTGGACTGGA CAGAGAGCGG CTATACTGGG
    52151 AGCTGAGCCA GCTGACCAAC AGCATCACAG AGCTGGGACC CTACACCCTG
    52201 GATAGGGACA GTCTCTATGT CAATGGCTTC AACCCTTGGA GCTCTGTGCC
    52251 AACCACCAGC ACTCCTGGGA CCTCCACAGT GCACCTGGCA ACCTCTGGGA
    52301 CTCCATCCTC CCTGCCTGGC CACACAACTG CTGGCCCTCT CCTGGTGCCG
    52351 TTCACCCTCA ACTTCACCAT CACCAACCTG AAGTACGAGG AGGACATGCA
    52401 TTGCCCTGGC TCCAGGAAGT TCAACACCAC AGAGAGAGTC CTGCAGAGTC
    52451 TGCATGGTCC CATGTTCAAG AACACCAGTG TTGGCCCTCT GTACTCTGGC
    52501 TGCAGACTGA CCTTGCTCAG GTCCGAGAAG GATGGAGCAG CCACTGGAGT
    52551 GGATGCCATC TGCACCCACC GTCTTGACCC CAAAAGCCCT GGACTGNACA
    52601 GNGAGCNGCT NTACTGGGAG CTNAGCCANC TGACCAANNN CATCNNNGAG
    52651 CTGGGNCCCT ACACCCTGGA CAGGNACAGT CTCTATGTCA ATGGTTTCAC
    52701 CCATCNGANC TCTGNGCCCA CCACCAGCAC TCCTGGGACC TCCACAGTGN
    52751 ACNTNGGNAC CTCNGGGACT CCATCCTCCN TCCCCNGCCN CACANCNNCT
    52801 GNCCCTCTCC TGNTNCCNTT CACCNTCAAC TTNACCATCA CCAACCTGCA
    52851 NTANGNGGAN NACATGCNNC NCCCNGGNTC CAGGAAGTTC AACACCACNG
    52901 AGNGNGTNCT GCAGGGTCTG CTNNNNCCCN TNTTCAAGAA CNCCAGTGTN
    52951 GGCCNTCTGT ACTCTGGCTG CAGACTGACC TNNCTCAGGN CNGAGAAGNA
    53001 TGGNGCAGCC ACTGGANTGG ATGCCATCTG CANCCACCNN CNTNANCCCA
    53051 AAAGNCCTGG ACTGNACAGN GAGCNGCTNT ACTGGGAGCT NAGCCANCTG
    53101 ACCAACAGCA TCACAGAGCT GGGACCCTAC ACCCTGGATA GGGACAGTCT
    53151 CTATGTCAAT GGTTTCACCC ATCGAAGCTC TATGCCCACC ACCAGTATTC
    53201 CTGGGACCTC TGCAGTGCAC CTGGAAACCT CTGGGACTCC AGCCTCCCTC
    53251 CCTGGCCACA CAGCCCCTGG CCCTCTCCTG GTGCCATTCA CCCTCAACTT
    53301 CACTATCACC AACCTGCAGT ATGAGGAGGA CATGCGTCAC CCTGGTTCCA
    53351 GGAAGTTCAA CACCACGGAG AGAGTCCTGC AGGGTCTGCT CAAGCCCTTG
    53401 TTCAAGAGCA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT
    53451 GCTCAGGCCT GAAAAACGTG GGGCAGCCAC CGGCGTGGAC ACCATCTGCA
    53501 CTCACCGCCT TGACCCTCTA AACCCTGGAC TGNACAGNGA GCNGCTNTAC
    53551 TGGGAGCTNA GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC
    53601 CCTGGACAGG NACAGTCTCT ATGTCAATGG TTTCACCCAT CNGANCTCTG
    53651 NGCCCACCAC CAGCACTCCT GGGACCTCCA CAGTGNACNT NGGNACCTCN
    53701 GGGACTCCAT CCTCCNTCCC CNGCCNCACA NCNNCTGNCC CTCTCCTGNT
    53751 NCCNTTCACC NTCAACTTNA CCATCACCAA CCTGCANTAN GNGGANNACA
    53801 TGCNNCNCCC NGGNTCCAGG AAGTTCAACA CCACNGAGNG NGTNCTGCAG
    53851 GGTCTGCTNN NNCCCNTNTT CAAGAACNCC AGTGTNGGCC NTCTGTACTC
    53901 TGGCTGCAGA CTGACCTNNC TCAGGNCNGA GAAGNATGGN GCAGCCACTG
    53951 GANTGGATGC CATCTGCANC CACCNNCNTN ANCCCAAAAG NCCTGGACTG
    54001 NACAGNGAGC NGCTNTACTG GGAGCTNAGC CANCTGACCA ANNNCATCNN
    54051 NGAGCTGGGN CCCTACACCC TGGACAGGNA CAGTCTCTAT GTCAATGGTT
    54101 TTCACCCTCG GAGCTCTGTG CCAACCACCA GCACTCCTGG GACCTCCACA
    54151 GTGCACCTGG CAACCTCTGG GACTCCATCC TCCCTGCCTG GCCACACAGC
    54201 CCCTGTCCCT CTCTTGATAC CATTCACCCT CAACTTTACC ATCACCAACC
    54251 TGCATTATGA AGAAAACATG CAACACCCTG GTTCCAGGAA GTTCAACACC
    54301 ACGGAGCGGG TCCTGCAGGG TCTGCTTGGT CCCATGTTCA AGAACACAAG
    54351 TGTCGGCCTT CTGTACTCTG GCTGCAGACT GACCTTGCTC AGGCCTGAGA
    54401 AGAATGGGGC AGCCACTGGA ATGGATGCCA TCTGCAGCCA CCGTCTTGAC
    54451 CCCAAAAGCC CTGGACTGNA CAGNGAGCNG CTNTACTGGG AGCTNAGCCA
    54501 NCTGACCAAN NNCATCNNNG AGCTGGGNCC CTACACCCTG GACAGGNACA
    54551 GTCTCTATGT CAATGGTTTC ACCCATCNGA NCTCTGNGCC CACCACCAGC
    54601 ACTCCTGGGA CCTCCACAGT GNACNTNGGN ACCTCNGGGA CTCCATCCTC
    54651 CNTCCCCNGC CNCACANCNN CTGNCCCTCT CCTGNTNCCN TTCACCNTCA
    54701 ACTTNACCAT CACCAACCTG CANTANGNGG ANNACATGCN NCNCCCNGGN
    54751 TCCAGGAAGT TCAACACCAC NGAGNGNGTN CTGCAGGGTC TGCTNNNNCC
    54801 CNTNTTCAAG AACNCCAGTG TNGGCCNTCT GTACTCTGGC TGCAGACTGA
    54851 CCTNNCTCAG GNCNGAGAAG NATGGNGCAG CCACTGGANT GGATGCCATC
    54901 TGCANCCACC NNCNTNANCC CAAAAGNCCT GGACTGNACA GNGAGCNGCT
    54951 NTACTGGGAG CTNAGCCANC TGACCAANNN CATCNNNGAG CTGGGNCCCT
    55001 ACACCCTGGA CAGGNACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAAC
    55051 TCTGTGCCCA CCACCAGTAC TCCTGGGACC TCCACAGTGT ACTGGGCAAC
    55101 CACTGGGACT CCATCCTCCT TCCCCGGCCA CACAGAGCCT GGCCCTCTCC
    55151 TGATACCATT CACTTTCAAC TTTACCATCA CCAACCTGCA TTATGAGGAA
    55201 AACATGCAAC ACCCTGGTTC CAGGAAGTTC AACACCACGG AGAGGGTTCT
    55251 GCAGGGTCTG CTCACGCCCT TGTTCAAGAA CACCAGTGTT GGCCCTCTGT
    55301 ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA GGAGGCAGCC
    55351 ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA TCGGACCTGG
    55401 ACTGNACAGN GAGCNGCTNT ACTGGGAGCT NAGCCANCTG ACCAANNNCA
    55451 TCNNNGAGCT GGGNCCCTAC ACCCTGGACA GGNACAGTCT CTATGTCAAT
    55501 GGTTTCACCC ATCNGANCTC TGNGCCCACC ACCAGCACTC CTGGGACCTC
    55551 CACAGTGNAC NTNGGNACCT CNGGGACTCC ATCCTCCNTC CCCNGCCNCA
    55601 CANCNNCTGN CCCTCTCCTG NTNCCNTTCA CCNTCAACTT NACCATCACC
    55651 AACCTGCANT ANGNGGANNA CATGCNNCNC CCNGGNTCCA GGAAGTTCAA
    55701 CACCACNGAG NGNGTNCTGC AGGGTCTGCT NNNNCCCNTN TTCAAGAACN
    55751 CCAGTGTNGG CCNTCTGTAC TCTGGCTGCA GACTGACCTN NCTCAGGNCN
    55801 GAGAAGNATG GNGCAGCCAC TGGANTGGAT GCCATCTGCA NCCACCNNCN
    55851 TNANCCCAAA AGNCCTGGAC TGNACAGNGA GCNGCTNTAC TGGGAGCTNA
    55901 GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC CCTGGACAGG
    55951 NACAGTCTCT ATGTCAATGG TTTCACCCAT CGGAGCTCTG TGCCAACCAC
    56001 CAGCAGTCCT GGGACCTCCA CAGTGCACCT GGCAACCTCT GGGACTCCAT
    56051 CCTCCCTGCC TGGCCACACA GCCCCTGTCC CTCTCTTGAT ACCATTCACC
    56101 CTCAACTTTA CCATCACCAA CCTGCATTAT GAAGAAAACA TGCAACACCC
    56151 TGGTTCCAGG AAGTTCAACA CCACGGAGAG GGTTCTGCAG GGTCTGCTCA
    56201 AGCCCTTGTT CAAGAGCACC AGTGTTGGCC CTCTGTACTC TGGCTGCAGA
    56251 CTGACCTTGC TCAGACCTGA GAAACATGGG GCAGCCACTG GAGTGGACGC
    56301 CATCTGCACC CTCCGCCTTG ATCCCACTGG TCCTGGACTG NACAGNGAGC
    56351 NGCTNTACTG GGAGCTNAGC CANCTGACCA ANNNCATCNN NGAGCTGGGN
    56401 CCCTACACCC TGGACAGGNA CAGTCTCTAT GTCAATGGTT TCACCCATCN
    56451 GANCTCTGNG CCCACCACCA GCACTCCTGG GACCTCCACA GTGNACNTNG
    56501 GNACCTCNGG GACTCCATCC TCCNTCCCCN GCCNCACANC NNCTGNCCCT
    56551 CTCCTGNTNC CNTTCACCNT CAACTTNACC ATCACCAACC TGCANTANGN
    56601 GGANNACATG CNNCNCCCNG GNTCCAGGAA GTTCAACACC ACNGAGNGNG
    56651 TNCTGCAGGG TCTGCTNNNN CCCNTNTTCA AGAACNCCAG TGTNGGCCNT
    56701 CTGTACTCTG GCTGCAGACT GACCTNNCTC AGGNCNGAGA AGNATGGNGC
    56751 AGCCACTGGA NTGGATGCCA TCTGCANCCA CCNNCNTNAN CCCAAAAGNC
    56801 CTGGACTGNA CAGNGAGCNG CTNTACTGGG AGCTNAGCCA NCTGACCAAN
    56851 NNCATCNNNG AGCTGGGNCC CTACACCCTG GACAGGNACA GTCTCTATGT
    56901 CAATGGTTTC ACCCATCGGA CCTCTGTGCC CACCACCAGC ACTCCTGGGA
    56951 CCTCCACAGT GCACCTGGCA ACCTCTGGGA CTCCATCCTC CCTGCCTGGC
    57001 CACACAGCCC CTGTCCCTCT CTTGATACCA TTCACCCTCA ACTTTACCAT
    57051 CACCAACCTG CAGTATGAGG AGGACATGCA TCGCCCTGGA TCTAGGAAGT
    57101 TCAACACCAC AGAGAGGGTC CTGCAGGGTC TGCTTAGTCC CATTTTCAAG
    57151 AACTCCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA CCTCTCTCAG
    57201 GCCCGAGAAG GATGGGGCAG CAACTGGAAT GGATGCTGTC TGCCTCTACC
    57251 ACCCTAATCC CAAAAGACCT GGGCTGGACA GAGAGCAGCT GTACTGCGAG
    57301 CTAAGCCAGC TGACCCACAA CATCACTGAG CTGGGCCCCT ACAGCCTGGA
    57351 CAGGGACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAAC TCTGTGCCCA
    57401 CCACCAGTAC TCCTGGGACC TCCACAGTGT ACTGGGCAAC CACTGGGACT
    57451 CCATCCTCCT TCCCCGGCCA CACANCNNCT GNCCCTCTCC TGNTNCCNTT
    57501 CACCNTCAAC TTNACCATCA CCAACCTGCA NTANGNGGAN NACATGCNNC
    57551 NCCCNGGNTC CAGGAAGTTC AACACCACNG AGNGNGTNCT GCAGGGTCTG
    57601 CTNNNNCCCN TNTTCAAGAA CNCCAGTGTN GGCCNTCTGT ACTCTGGCTG
    57651 CAGACTGACC TNNCTCAGGN CNGAGAAGNA TGGNGCAGCC ACTGGANTGG
    57701 ATGCCATCTG CANCCACCNN CNTNANCCCA AAAGNCCTGG ACTGNACAGN
    57751 GAGCNGCTNT ACTGGGAGCT NAGCCANCTG ACCAANNNCA TCNNNGAGCT
    57801 GGGNCCCTAC ACCCTGGACA GGNACAGTCT CTATGTCAAT GGTTTCACCC
    57851 ATTGGAGCTC TGGGCTCACC ACCAGCACTC CTTGGACTTC CACAGTTGAC
    57901 CTTGGAACCT CAGGGACTCC ATCCCCCGTC CCCAGCCCCA CAACTGCTGG
    57951 CCCTCTCCTG GTGCCATTCA CCCTAAACTT CACCATCACC AACCTGCAGT
    58001 ATGAGGAGGA CATGCATCGC CCTGGATCTA GGAAGTTCAA CGCCACAGAG
    58051 AGGGTCCTGC AGGGTCTGCT TAGTCCCATA TTCAAGAACA CCAGTGTTGG
    58101 CCCTCTGTAC TCTGGCTGCA GACTGACCTT GCTCAGACCT GAGAAGCAGG
    58151 AGGCAGCCAC TGGAGTGGAC ACCATCTGTA CCCACCGCGT TGATCCCATC
    58201 GGACCTGGAC TGNACAGNGA GCUGCTNTAC TGGGAGCTNA GCCANCTGAC
    58251 CAANNNCATC NNNGAGCTGG GNCCCTACAC CCTGGACAGG NACAGTCTCT
    58301 ATGTCAATGG TTTCACCCAT CNGANCTCTG NGCCCACCAC CAGCACTCCT
    58351 GGGACCTCCA CAGTGNACNT NGGNACCTCN GGGACTCCAT CCTCCNTCCC
    58401 CNGCCNCACA NCNNCTGNCC CTCTCCTGNT NCCNTTCACC NTCAACTTNA
    58451 CCATCACCAA CCTGCANTAN GNGGANNACA TGCNNCNCCC NGGNTCCAGG
    58501 AAGTTCAACA CCACNGAGNG NGTNCTGCAG GGTCTGCTNN NNCCCNTNTT
    58551 CAAGAACNCC AGTGTNGGCC NTCTGTACTC TGGCTGCAGA CTGACCTNNC
    58601 TCAGGNCNGA GAAGNATGGN GCAGCCACTG GANTGGATGC CATCTGCANC
    58651 CACCNNCNTN ANCCCAAAAG NCCTGGACTG NACAGNGAGC NGCTNTACTG
    58701 GGAGCTNAGC CANCTGACCA ANNNCATCNN NGAGCTGGGN CCCTACACCC
    58751 TGGACAGGNA CAGTCTCTAT GTCAATGGTT TCACCCATCG GAGCTTTGGG
    58801 CTCACCACCA GCACTCCTTG GACTTCCACA GTTGACCTTG GAACCTCAGG
    58851 GACTCCATCC CCCGTCCCCA GCCCCACAAC TGCTGGCCCT CTCCTGGTGC
    58901 CATTCACCCT AAACTTCACC ATCACCAACC TGCAGTATGA GGAGGACATG
    58951 CATCGCCCTG GCTCCAGGAA GTTCAACACC ACGGAGAGGG TCCTTCAGGG
    59001 TCTGCTTACG CCCTTGTTCA GGAACACCAG TGTCAGCTCT CTGTACTCTG
    59051 GTTGCAGACT GACCTTGCTC AGGCCTGAGA AGGATGGGGC AGCCACCAGA
    59101 GTGGATGCTG TCTGCACCCA TCGTCCTGAC CCCAAAAGCC CTGGACTGNA
    59151 CAGNGAGCNG CTNTACTGGG AGCTNAGCCA NCTGACCAAN NNCATCNNNG
    59201 AGCTGGGNCC CTACACCCTG GACAGGNACA GTCTCTATGT CAATGGTTTC
    59251 ACCCATCNGA NCTCTGNGCC CACCACCAGC ACTCCTGGGA CCTCCACAGT
    59301 GNACNTNGGN ACCTCNGGGA CTCCATCCTC CNTCCCCNGC CNCACANCNN
    59351 CTGNCCCTCT CCTGNTNCCN TTCACCNTCA ACTTNACCAT CACCAACCTG
    59401 CANTANGNGG ANNACATGCN NCNCCCNGGN TCCAGGAAGT TCAACACCAC
    59451 NGAGNGNGTN CTGCAGGGTC TGCTNNNNCC CNTNTTCAAG AACNCCAGTG
    59501 TNGGCCNTCT GTACTCTGGC TGCAGACTGA CCTNNCTCAG GNCNGAGAAG
    59551 NATGGNGCAG CCACTGGANT GGATGCCATC TGCANCCACC NNCNTNANCC
    59601 CAAAAGNCCT GGACTGNACA GNGAGCNGCT NTACTGGGAG CTNAGCCANC
    59651 TGACCAANNN CATCNNNGAG CTGGGNCCCT ACACCCTGGA CAGGNACAGT
    59701 CTCTATGTCA ATGGTTTCAC CCATTGGATC CCTGTGCCCA CCAGCAGCAC
    59751 TCCTGGGACC TCCACAGTGG ACCTTGGGTC AGGGACTCCA TCCTCCCTCC
    59801 CCAGCCCCAC AACTGCTGGC CCTCTCCTGG TACCATTCAC CCTCAACTTC
    59851 ACCATCACCA ACCTGCAGTA TGGGGAGGAC ATGGGTCACC CTGGCTCCAG
    59901 GAAGTTCAAC ACCACAGAGA GGGTCCTGCA GGGTCTGCTT GGTCCCATAT
    59951 TCAAGAACAC CAGTGTTGGC CCTCTGTACT CTGGCTGCAG ACTGACCTCT
    60001 CTCAGGTCCG AGAAGGATGG AGCAGCCACT GGAGTGGATG CCATCTGCAT
    60051 CCATCATCTT GACCCCAAAA GCCCTGGACT GNACAGNGAG CNGCTNTACT
    60101 GGGAGCTNAG CCANCTGACC AANNNCATCN NNGAGCTGGG NCCCTACACC
    60151 CTGGACAGGN ACAGTCTCTA TGTCAATGGT TTCACCCATC NGANCTCTGN
    60201 GCCCACCACC AGCACTCCTG GGACCTCCAC AGTGNACNTN GGNACCTCNG
    60251 GGACTCCATC CTCCNTCCCC NGCCNCACAN CNNCTGNCCC TCTCCTGNTN
    60301 CCNTTCACCN TCAACTTNAC CATCACCAAC CTGCANTANG NGGANNACAT
    60351 GCNNCNCCCN GGNTCCAGGA AGTTCAACAC CACNGAGNGN GTNCTGCAGG
    60401 GTCTGCTNNN NCCCNTNTTC AAGAACNCCA GTGTNGGCCN TCTGTACTCT
    60451 GGCTGCAGAC TGACCTNNCT CAGGNCNGAG AAGNATGGNG CAGCCACTGG
    60501 ANTGGATGCC ATCTGCANCC ACCNNCNTNA NCCCAAAAGN CCTGGACTGN
    60551 ACAGNGAGCN GCTNTACTGG GAGCTNAGCC ANCTGACCAA NNNCATCNNN
    60601 GAGCTGGGNC CCTACACCCT GGACAGGNAC AGTCTCTATG TCAATGGTTT
    60651 CACCCATCAG ACCTTTGCGC CCAACACCAG CACTCCTGGG ACCTCCACAG
    60701 TGGACCTTGG GACCTCAGGG ACTCCATCCT CCCTCCCCAG CCCTACATCT
    60751 GCTGGCCCTC TCCTGGTGCC ATTCACCCTC AACTTCACCA TCACCAACCT
    60801 GCAGTACGAG GAGGACATGC ATCACCCAGG CTCCAGGAAG TTCAACACCA
    60851 CGGAGCGGGT CCTGCAGGGT CTGCTTGGTC CCATGTTCAA GAACACCAGT
    60901 GTCGGCCTTC TGTACTCTGG CTGCAGACTG ACCTTGCTCA GGCCTGAGAA
    60951 GAATGGGGCA GCCACCAGAG TGGATGCTGT CTGCACCCAT CGTCCTGACC
    61001 CCAAAAGCCC TGGACTGNAC AGNGAGCNGC TNTACTGGGA GCTNAGCCAN
    61051 CTGACCAANN NCATCNNNGA GCTGGGNCCC TACACCCTGG ACAGGNACAG
    61101 TCTCTATGTC AATGGTTTCA CCCATCNGAN CTCTGNGCCC ACCACCAGCA
    61151 CTCCTGGGAC CTCCACAGTG NACNTNGGNA CCTCNGGGAC TCCATCCTCC
    61201 NTCCCCNGCC NCACAGCCCC TGTCCCTCTC TTGATACCAT TCACCCTCAA
    61251 CTTTACCATC ACCAACCTGC ATTATGAAGA AAACATGCAA CACCCTGGTT
    61301 CCAGGAAGTT CAACACCACG GAGAGGGTTC TGCAGGGTCT GCTCAAGCCC
    61351 TTGTTCAAGA GCACCAGCGT TGGCCCTCTG TACTCTGGCT GCAGACTGAC
    61401 CTTGCTCAGA CCTGAGAAAC ATGGGGCAGC CACTGGAGTG GACGCCATCT
    61451 GCACCCTCCG CCTTGATCCC ACTGGTCCTG GACTGGACAG AGAGCGGCTA
    61501 TACTGGGAGC TGAGCCAGCT GACCAACAGC GTTACAGAGC TGGGCCCCTA
    61551 CACCCTGGAC AGGGACAGTC TCTATGTCAA TGGCTTCACC CAGCGGAGCT
    61601 CTGTGCCAAC CACCAGTATT CCTGGGACCT CTGCAGTGCA CCTGGAAACC
    61651 TCTGGGACTC CAGCCTCCCT CCCTGGCCAC ACAGCCCCTG GCCCTCTCCT
    61701 GGTGCCATTC ACCCTCAACT TCACTATCAC CAACCTGCAG TATGAGGTGG
    61751 ACATGCGTCA CCCTGGTTCC AGGAAGTTCA ACACCACGGA GAGAGTCCTG
    61801 CAGGGTCTGC TCAAGCCCTT GTTCAAGAGC ACCAGTGTTG GCCCTCTGTA
    61851 CTCTGGCTGC AGACTGACCT TGCTCAGGCC TGAAAAACGT GGGGCAGCCA
    61901 CCGGCGTGGA CACCATCTGC ACTCACCGCC TTGACCCTCT AAACCCTGGA
    61951 CTGGACAGAG AGCAGCTATA CTGGGAGCTG AGCAAACTGA CCCGTGGCAT
    62001 CATCGAGCTG GGCCCCTACC TCCTGGACAG AGGCAGTCTC TATGTCAATG
    62051 GTTTCACCCA TCGGAACTTT GTGCCCATCA CCAGCACTCC TGGGACCTCC
    62101 ACAGTACACC TAGGAACCTC TGAAACTCCA TCCTCCCTAC CTAGACCCAT
    62151 AGTGCCTGGC CCTCTCCTGG TGCCATTCAC CCTCAACTTC ACCATCACCA
    62201 ACTTGCAGTA TGAGGAGGCC ATGCGACACC CTGGCTCCAG GAAGTTCAAT
    62251 ACCACGGAGA GGGTCCTACA GGGTCTGCTC AGGCCCTTGT TCAAGAATAC
    62301 CAGTATCGGC CCTCTGTACT CCAGCTGCAG ACTGACCTTG CTCAGGCCAG
    62351 AGAAGGACAA GGCAGCCACC AGAGTGGATG CCATCTGTAC CCACCACCCT
    62401 GACCCTCAAA GCCCTGGACT GAACAGAGAG CAGCTGTACT GGGAGCTGAG
    62451 CCAGCTGACC CACGGCATCA CTGAGCTGGG CCCCTACACC CTGGACAGGG
    62501 ACAGTCTCTA TGTCGATGGT TTCACTCATT GGAGCCCCAT ACCGACCACC
    62551 AGCACTCCTG GGACCTCCAT AGTGAACCTG GGAACCTCTG GGATCCCACC
    62601 TTCCCTCCCT GAAACTACAN CNNCTGNCCC TCTCCTGNTN CCNTTCACCN
    62651 TCAACTTNAC CATCACCAAC CTGCANTANG NGGANNACAT GCNNCNCCCN
    62701 GGNTCCAGGA AGTTCAACAC CACNGAGAGG GTTCTGCAGG GTCTGCTCAA
    62751 GCCCTTGTTC AAGAGCACCA GTGTTGGCCC TCTGTATTCT GGCTGCAGAC
    62801 TGACCTTGCT CAGGCCTGAG AAGGACGGAG TAGCCACCAG AGTGGACGCC
    62851 ATCTGCACCC ACCGCCCTGA CCCCAAAATC CCTGGGCTAG ACAGACAGCA
    62901 GCTATACTGG GAGCTGAGCC AGCTGACCCA CAGCATCACT GAGCTGGGAC
    62951 CCTACACCCT GGATAGGGAC AGTCTCTATG TCAATGGTTT CACCCAGCGG
    63001 AGCTCTGTGC CCACCACCAG CACTCCTGGG ACTTTCACAG TACAGCCGGA
    63051 AACCTCTGAG ACTCCATCAT CCCTCCCTGG CCCCACAGCC ACTGGCCCTG
    63101 TCCTGCTGCC ATTCACCCTC AATTTTACCA TCACTAACCT GCAGTATGAG
    63151 GAGGACATGC ATCGCCCTGG CTCCAGGAAG TTCAACACCA CGGAGAGGGT
    63201 CCTTCAGGGT CTGCTTATGC CCTTGTTCAA GAACACCAGT GTCAGCTCTC
    63251 TGTACTCTGG TTGCAGACTG ACCTTGCTCA GGCCTGAGAA GGATGGGGCA
    63301 GCCACCAGAG TGGATGCTGT CTGCACCCAT CGTCCTGACC CCAAAAGCCC
    63351 TGGACTGGAC AGAGAGCGGC TGTACTGGAA GCTGAGCCAG CTGACCCACG
    63401 GCATCACTGA GCTGGGCCCC TACACCCTGG ACAGGCACAG TCTCTATGTC
    63451 AATGGTTTCA CCCATCAGAG CTCTATGACG ACCACCAGAA CTCCTGATAC
    63501 CTCCACAATG CACCTGGCAA CCTCGAGAAC TCCAGCCTCC CTGTCTGGAC
    63551 CTACGACCGC CAGCCCTCTC CTGGTGCTAT TCACAATTAA CTTCACCATC
    63601 ACTAACCTGC GGTATGAGGA GAACATGCAT CACCCTGGCT CTAGAAAGTT
    63651 TAACACCACG GAGAGAGTCC TTCAGGGTCT GCTCAGGCCT GTGTTCAAGA
    63701 ACACCAGTGT TGGCCCTCTG TACTCTGGCT GCAGACTGAC CTTGCTCAGG
    63751 CCCAAGAAGG ATGGGGCAGC CACCAAAGTG GATGCCATCT GCACCTACCG
    63801 CCCTGATCCC AAAAGCCCTG GACTGGACAG AGAGCAGCTA TACTGGGAGC
    63851 TGAGCCAGCT AACCCACAGC ATCACTGAGC TGGGCCCCTA CACCCTGGAC
    63901 AGGGACAGTC TCTATGTCAA TGGTTTCACA CAGCGGAGCT CTGTGCCCAC
    63951 CACTAGCATT CCTGGGACCC CCACAGTGGA CCTGGGAACA TCTGGGACTC
    64001 CAGTTTCTAA ACCTGGTCCC TCGGCTGCCA GCCCTCTCCT GGTGCTATTC
    64051 ACTCTCAACT TCACCATCAC CAACCTGCGG TATGAGGAGA ACATGCAGCA
    64101 CCCTGGCTCC AGGAAGTTCA ACACCACGGA GAGGGTCCTT CAGGGCCTGC
    64151 TCAGGTCCCT GTTCAAGAGC ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC
    64201 AGACTGACTT TGCTCAGGCC TGAAAAGGAT GGGACAGCCA CTGGAGTGGA
    64251 TGCCATCTGC ACCCACCACC CTGACCCCAA AAGCCCTAGG CTGGACAGAG
    64301 AGCAGCTGTA TTGGGAGCTG AGCCAGCTGA CCCACAATAT CACTGAGCTG
    64351 GGCCACTATG CCCTGGACAA CGACAGCCTC TTTGTCAATG GTTTCACTCA
    64401 TCGGAGCTCT GTGTCCACCA CCAGCACTCC TGGGACCCCC ACAGTGTATC
    64451 TGGGAGCATC TAAGACTCCA GCCTCGATAT TTGGCCCTTC AGCTGCCAGC
    64501 CATCTCCTGA TACTATTCAC CCTCAACTTC ACCATCACTA ACCTGCGGTA
    64551 TGAGGAGAAC ATGTGGCCTG GCTCCAGGAA GTTCAACACT ACAGAGAGGG
    64601 TCCTTCAGGG CCTGCTAAGG CCCTTGTTCA AGAACACCAG TGTTGGCCCT
    64651 CTGTACTCTG GCTCCAGGCT GACCTTGCTC AGGCCAGAGA AAGATGGGGA
    64701 AGCCACCGGA GTGGATGCCA TCTGCACCCA CCGCCCTGAC CCCACAGGCC
    64751 CTGGGCTGGA CAGAGAGCAG CTGTATTTGG AGCTGAGCCA GCTGACCCAC
    64801 AGCATCACTG AGCTGGGCCC CTACACACTG GACAGGGACA GTCTCTATGT
    64851 CAATGGTTTC ACCCATCGGA GCTCTGTACC CACCACCAGC ACCGGGGTGG
    64901 TCAGCGAGGA GCCATTCACA CTGAACTTCA CCATCAACAA CCTGCGCTAC
    64951 ATGGCGGACA TGGGCCAACC CGGCTCCCTC AAGTTCAACA TCACAGACAA
    65001 CGTCATGAAG CACCTGCTCA GTCCTTTGTT CCAGAGGAGC AGCCTGGGTG
    65051 CACGGTACAC AGGCTGCAGG GTCATCGCAC TAAGGTCTGT GAAGAACGGT
    65101 GCTGAGACAC GGGTGGACCT CCTCTGCACC TACCTGCAGC CCCTCAGCGG
    65151 CCCAGGTCTG CCTATCAAGC AGGTGTTCCA TGAGCTGAGC CAGCAGACCC
    65201 ATGGCATCAC CCGGCTGGGC CCCTACTCTC TGGACAAAGA CAGCCTCTAC
    65251 CTTAACGGTT ACAATGAACC TGGTCTAGAT GAGCCTCCTA CAACTCCCAA
    65301 GCCAGCCACC ACATTCCTGC CTCCTCTGTC AGAAGCCACA ACAGCCATGG
    65351 GGTACCACCT GAAGACCCTC ACACTCAACT TCACCATCTC CAATCTCCAG
    65401 TATTCACCAG ATATGGGCAA GGGCTCAGCT ACATTCAACT CCACCGAGGG
    65451 GGTCCTTCAG CACCTGCTCA GACCCTTGTT CCAGAAGAGC AGCATGGGCC
    65501 CCTTCTACTT GGGTTGCCAA CTGATCTCCC TCAGGCCTGA GAAGGATGGG
    65551 GCAGCCACTG GTGTGGACAC CACCTGCACC TACCACCCTG ACCCTGTGGG
    65601 CCCCGGGCTG GACATACAGC AGCTTTACTG GGAGCTGAGT CAGCTGACCC
    65651 ATGGTGTCAC CCAACTGGGC TTCTATGTCC TGGACAGGGA TAGCCTCTTC
    65701 ATCAATGGCT ATGCACCCCA GAATTTATCA ATCCGGGGCG AGTACCAGAT
    65751 AAATTTCCAC ATTGTCAACT GGAACCTCAG TAATCCAGAC CCCACATCCT
    65801 CAGAGTACAT CACCCTGCTG AGGGACATCC AGGACAAGGT CACCACACTC
    65851 TACAAAGGCA GTCAACTACA TGACACATTC CGCTTCTGCC TGGTCACCAA
    65901 CTTGACGATG GACTCCGTGT TGGTCACTGT CAAGGCATTG TTCTCCTCCA
    65951 ATTTGGACCC CAGCCTGGTG GAGCAAGTCT TTCTAGATAA GACCCTGAAT
    66001 GCCTCATTCC ATTGGCTGGG CTCCACCTAC CAGTTGGTGG ACATCCATGT
    66051 GACAGAAATG GAGTCATCAG TTTATCAACC AACAAGCAGC TCCAGCACCC
    66101 AGCACTTCTA CCTGAATTTC ACCATCACCA ACCTACCATA TTCCCAGGAC
    66151 AAAGCCCAGC CAGGCACCAC CAATTACCAG AGGAACAAAA GGAATATTGA
    66201 GGATGCGCTC AACCAACTCT TCCGAAACAG CAGCATCAAG AGTTATTTTT
    66251 CTGACTGTCA AGTTTCAACA TTCAGGTCTG TCCCCAACAG GCACCACACC
    66301 GGGGTGGACT CCCTGTGTAA CTTCTCGCCA CTGGCTCGGA GAGTAGACAG
    66351 AGTTGCCATC TATGAGGAAT TTCTGCGGAT GACCCGGAAT GGTACCCAGC
    66401 TGCAGAACTT CACCCTGGAC AGGAGCAGTG TCCTTGTGGA TGGGTATTCT
    66451 CCCAACAGAA ATGAGCCCTT AACTGGGAAT TCTGACCTTC CCTTCTGGGC
    66501 TGTCATCCTC ATCGGCTTGG CAGGACTCCT GGGACTCATC ACATGCCTGA
    66551 TCTGCGGTGT CCTGGTGACC ACCCGCCGGC GGAAGAAGGA AGGAGAATAC
    66601 AACGTCCAGC AACAGTGCCC AGGCTACTAC CAGTCACACC TAGACCTGGA
    66651 GGATCTGCAA TGACTGGAAC TTGCCGGTGC CTGGGGTGCC TTTCCCCCAG
    66701 CCAGGGTCCA AAGAAGCTTG GCTGGGGCAG AAATAAACCA TATTGGTCGG
    66751 AAAAAAAAAA AAAAA
  • [0057]
  • 1 7 1 57082 DNA Homo sapiens misc_feature (2205)..(11679) Exon 1 1 ggtgcgcacc actatgtctg gctaattttt gtattttttt gtagagacat ggtttcacca 60 tgttggccag gctggtctcg aattcctgac ttcaagtaat ccacccacct cagcctccca 120 aagtgctggg attacaagca tgagccacca tgcatggcct aaagcttctt ttaaagccac 180 caagtccctt cccatgttag cccactaatc catgggttag tcatgaatgg attaatctat 240 tcatacggac agagccctca tcacccaatc acctcttaaa ggccccacct ctcaatactg 300 ccacactggg gattaagttt caacagagtt ttggagggga cattcaaatc atagtaatgc 360 ccaaagtgaa aaatcttccc tgcacttttc cctcaacaaa aacagccaga gatagtgagc 420 tgccaggaaa ttcttttttt tttcctcttc tgtcctaaat cagcatcgct agacctttac 480 atgattcaac ctcatcttct tcaccctctg ggtcatgaaa ttttatttat ttatttatta 540 ttttcttggg acagactctg gctctgtcgc ccaggctgaa gtgcagtggt gtgatcttgg 600 ctcactgcaa cctccgcctc ccgggttcaa gcgattctcc tgcctcagcc tcctgagtag 660 ctgggattac aggtgggcgc caccacaccc agctaatttt ttgtattttt agtagagatg 720 gggtttcacc atattagcca ggatggtctc catctcttga cctcgtgatc tgcccacctc 780 agcctcccaa aatgctggga ttacaggcat gagacaccac gcccagcagg ccagggtcat 840 gagattttaa tcaagagcaa cttccactga ttcctgagag tgcatctgtg ggcccctgct 900 ctgatctgaa cagaagtgcc gtgtcttctc tgacctccac ttctcaattc aagagcctta 960 gtatctgcca gtatcacaca ctgagcatta gctccatctc atgggggtgt aggtaggggc 1020 tctatctgca tctttctttc tttttttctt tctttccctt cctcccttcc tcactccctc 1080 ggtcctctct ttctttcctt ttctttcttc cttcctccct tcctccctcc ctccctctct 1140 ctttctctct ttctttcttt ccttctttct ttctttctct cttccttccc tccctccctc 1200 cttccttcct ttctctttct ttctctttct ttcttttttt ccttccttcc ttccttcttt 1260 ctctttctct ccctcccttc cttccttcct tccttccttc cttcctttct ttctttcttt 1320 ctttctttct ttctttcttt ctttctttct ttctttcttc cttccttcct tccttccttc 1380 cttccttcct tccttccttt cttttctttc tttctctttc tttttgagac agagctctta 1440 ttacccatgc tggagtgcag tggtgtgacc ttggcttact gcaacatctg cctcctaggg 1500 tcaagtgatt ctcctgcctc agcctcctaa gtagctggga ttacagacac atgccaccac 1560 acccaatatt tatttttatt aaaatttttt ttaaaattat ttttaaaaaa ttaaaaataa 1620 ttttgtattt ttagtagaga cggggtttct ccatgttggt caggctgatc tcaaactccc 1680 aacctcaggt gatcctccca cctcacctcc caaagtgctg ggattacagg catgagccac 1740 cgtgcccagc ctggttcctg gtttctaaga catcacacac acacacacac acacacacac 1800 acactcacac actcagagag agagagagag agaggatcat taagacatga tacactaaga 1860 aattctattc tgcagacact gagaatccgt taaaaagttt gaagggaaga attgagatca 1920 tcaggtgttt atttgaggaa attgtctgtg gttgaactat cctttccttt ctctccctga 1980 gatttggtct tctcaattag aagcgttgca caattccccc aacctccata catacggcag 2040 ctcttctaga cacaggtttt cccaggtcaa atgcggggac cccagccata tctcccaccc 2100 tgagaaattt tggagtttca gggagctcag aagctctgca gaggccaccc tctctgaggg 2160 gattcttctt agacctccat ccagaggcaa atgttgacct gtccatgctg aaaccctcag 2220 gccttcctgg gtcatcttct cccacccgct ccttgatgac agggagcagg agcactaaag 2280 ccacaccaga aatggattca ggactgacag gagccacctt gtcacctaag acatctacag 2340 gtgcaatcgt ggtgacagaa catactctgc cctttacttc cccagataag accttggcca 2400 gtcctacatc ttcggttgtg ggaagaacca cccagtcttt gggggtgatg tcctctgctc 2460 tccctgagtc aacctctaga ggaatgacac actccgagca aagaaccagc ccatcgctga 2520 gtccccaggt caatggaact ccctctagga actaccctgc tacaagcatg gtttcaggat 2580 tgagttcccc aaggaccagg accagttcca cagaaggaaa ttttaccaaa gaagcatcta 2640 catacacact cactgtagag accacaagtg gcccagtcac tgagaagtac acagtcccca 2700 ctgagacctc aacaactgaa ggtgacagca cagagacccc ctgggacaca agatatattc 2760 ctgtaaaaat cacatctcca atgaaaacat ttgcagattc aactgcatcc aaggaaaatg 2820 ccccagtgtc tatgactcca gctgagacca cagttactga ctcacatact ccaggaagga 2880 caaacccatc atttgggaca ctttattctt ccttccttga cctatcacct aaagggaccc 2940 caaattccag aggtgaaaca agcctggaac tgattctatc aaccactgga tatcccttct 3000 cctctcctga acctggctct gcaggacaca gcagaataag taccagtgcg cctttgtcat 3060 catctgcttc agttctcgat aataaaatat cagagaccag catattctca ggccagagtc 3120 tcacctcccc tctgtctcct ggggtgcccg aggccagagc cagcacaatg cccaactcag 3180 ctatcccttt ttccatgaca ctaagcaatg cagaaacaag tgccgaaagg gtcagaagca 3240 caatttcctc tctggggact ccatcaatat ccacaaagca gacagcagag actatcctta 3300 ccttccatgc cttcgctgag accatggata tacccagcac ccacatagcc aagactttgg 3360 cttcagaatg gttgggaagt ccaggtaccc ttggtggcac cagcacttca gcgctgacaa 3420 ccacatctcc atctaccact ttagtctcag aggagaccaa cacccatcac tccacgagtg 3480 gaaaggaaac agaaggaact ttgaatacat ctatgactcc acttgagacc tctgctcctg 3540 gagaagagtc cgaaatgact gccaccttgg tccccactct aggttttaca actcttgaca 3600 gcaagatcag aagtccatct caggtctctt catcccaccc aacaagagag ctcagaacca 3660 caggcagcac ctctgggagg cagagttcca gcacagctgc ccacgggagc tctgacatcc 3720 tgagggcaac cacttccagc acctcaaaag catcatcatg gaccagtgaa agcacagctc 3780 agcaatttag tgaaccccag cacacacagt gggtggagac aagtcctagc atgaaaacag 3840 agagaccccc agcatcaacc agtgtggcag cccctatcac cacttctgtt ccctcagtgg 3900 tctctggctt caccaccctg aagaccagct ccacaaaagg gatttggctt gaagaaacat 3960 ctgcagacac actcatcgga gaatccacag ctggcccaac cacccatcag tttgctgttc 4020 ccactgggat ttcaatgaca ggaggcagca gcaccagggg aagccagggc acaacccacc 4080 tactcaccag agccacagca tcatctgaga catccgcaga tttgactctg gccacgaacg 4140 gtgtcccagt ctccgtgtct ccagcagtga gcaagacggc tgctggctca agtcctccag 4200 gagggacaaa gccatcatat acaatggttt cttctgtcat ccctgagaca tcatctctac 4260 agtcctcagc tttcagggaa ggaaccagcc tgggactgac tccattaaac actagacatc 4320 ccttctcttc ccctgaacca gactctgcag gacacaccaa gataagcacc agcattcctc 4380 tgttgtcatc tgcttcagtt cttgaggata aagtgtcagc gaccagcaca ttctcacacc 4440 acaaagccac ctcatctatt accacaggga ctcctgaaat ctcaacaaag acaaagccca 4500 gctcagccgt tctttcctcc atgaccctaa gcaatgcagc aacaagtcct gaaagagtca 4560 gaaatgcaac ttcccctctg actcatccat ctccatcagg ggaagagaca gcagggagtg 4620 tcctcactct cagcacctct gctgagacta cagactcacc taacatccac ccaactggga 4680 cactgacttc agaatcgtca gagagtccta gcactctcag cctcccaagt gtctctggag 4740 tcaaaaccac attttcttca tctactcctt ccactcatct atttactagt ggagaagaaa 4800 cagaggaaac ttcgaatcca tctgtgtctc aacctgagac ttctgtttcc agagtaagga 4860 ccaccttggc cagcacctct gtccctaccc cagtattccc caccatggac acctggccta 4920 cacgttcagc tcagttctct tcatcccacc tagtgagtga gctcagagct acgagcagta 4980 cctcagttac aaactcaact ggttcagctc ttcctaaaat atctcacctc actgggacgg 5040 caacaatgtc acagaccaat agagacacgt ttaatgactc tgctgcaccc caaagcacaa 5100 cttggccaga gactagtccc agattcaaga cagggttacc ttcagcaaca accactgttt 5160 caacctctgc cacttctctc tctgctactg taatggtctc taaattcact tctccagcaa 5220 ctagttccat ggaagcaact tctatcaggg aaccatcaac aaccatcctc acaacagaga 5280 ccacgaatgg cccaggctct atggctgtgg cttctaccaa catcccaatt ggaaagggct 5340 acattactga aggaagattg gacacaagcc atctgcccat tggaaccaca gcttcctctg 5400 agacatctat ggattttacc atggccaaag aaagtgtctc aatgtcagta tctccatctc 5460 agtccatgga tgctgctggc tcaagcactc caggaaggac aagccaattc gttgacacat 5520 tttctgatga tgtctatcat ttaacatcca gagaaattac aatacctaga gatggaacaa 5580 gctcagctct gactccacaa atgactgcaa ctcaccctcc atctcctgat cctggctctg 5640 ctagaagcac ctggcttggc atcttgtcct catctccttc ttctcctact cccaaagtca 5700 caatgagctc cacattttca actcagagag tcaccacaag catgataatg gacacagttg 5760 aaactagtcg gtggaacatg cccaacttac cttccacgac ttccttgaca ccaagtaata 5820 ttccaacaag tggtgccata ggaaaaagca ccctggttcc cttggacact ccatctccag 5880 ccacatcatt ggaggcatca gaagggggac ttccaaccct cagcacctac cctgaatcaa 5940 caaacacacc cagcatccac ctcggagcac acgctagttc agaaagtcca agcaccatca 6000 aacttaccat ggcttcagta gtaaaacctg gctcttacac acctctcacc ttcccctcaa 6060 tagagaccca cattcatgta tcaacagcca gaatggctta ctcttctggg tcttcacctg 6120 agatgacagc tcctggagag actaacactg gtagtacctg ggaccccacc acctacatca 6180 ccactacgga tcctaaggat acaagttcag ctcaggtctc tacaccccac tcagtgagga 6240 cactcagaac cacagaaaac catccaaaga cagagtccgc caccccagct gcttactctg 6300 gaagtcctaa aatctcaagt tcacccaatc tcaccagtcc ggccacaaaa gcatggacca 6360 tcacagacac aactgaacac tccactcaat tacattacac aaaattggca gaaaaatcat 6420 ctggatttga gacacagtca gctccaggac ctgtctctgt agtaatccct acctccccta 6480 ccattggaag cagcacattg gaactaactt ctgatgtccc aggggaaccc ctggtccttg 6540 ctcccagtga gcagaccaca atcactctcc ccatggcaac atggctgagt accagtttga 6600 cagaggaaat ggcttcaaca gaccttgata tttcaagtcc aagttcaccc atgagtacat 6660 ttgctatttt tccacctatg tccacacctt ctcatgaact ttcaaagtca gaggcagata 6720 ccagtgccat tagaaataca gattcaacaa cgttggatca gcacctagga atcaggagtt 6780 tgggcagaac tggggactta acaactgttc ctatcacccc actgacaacc acgtggacca 6840 gtgtgattga acactcaaca caagcacagg acaccctttc tgcaacgatg agtcctactc 6900 acgtgacaca gtcactcaaa gatcaaacat ctataccagc ctcagcatcc ccttcccatc 6960 ttactgaagt ctaccctgag ctcgggacac aagggagaag ctcctctgag gcaaccactt 7020 tttggaaacc atctacagac acactgtcca gagagattga gactggccca acaaacattc 7080 aatccactcc acccatggac aacacaacaa cagggagcag tagtagtgga gtcaccctgg 7140 gcatagccca ccttcccata ggaacatcct ccccagctga gacatccaca aacatggcac 7200 tggaaagaag aagttctaca gccactgtct ctatggctgg gacaatggga ctccttgtta 7260 ctagtgctcc aggaagaagc atcagccagt cattaggaag agtttcctct gtcctttctg 7320 agtcaactac tgaaggagtc acagattcta gtaagggaag cagcccaagg ctgaacacac 7380 agggaaatac agctctctcc tcctctcttg aacccagcta tgctgaagga agccagatga 7440 gcacaagcat ccctctaacc tcatctccta caactcctga tgtggaattc atagggggca 7500 gcacattttg gaccaaggag gtcaccacag ttatgacctc agacatctcc aagtcttcag 7560 caaggacaga gtccagctca gctaccctta tgtccacagc tttgggaagc actgaaaata 7620 caggaaaaga aaaactcaga actgcctcta tggatcttcc atctccaact ccatcaatgg 7680 aggtgacacc atggatttct ctcactctca gtaatgcccc caataccaca gattcacttg 7740 acctcagcca tggggtgcac accagctctg cagggacttt ggccactgac aggtcattga 7800 atactggtgt cactagagcc tccagattgg aaaacggctc tgatacctct tctaagtccc 7860 tgtctatggg aaacagcact cacacttcca tgacttacac agagaagagt gaagtgtctt 7920 cttcaatcca tccccgacct gagacctcag ctcctggagc agagaccact ttgacttcca 7980 ctcctggaaa cagggccata agcttaacat tgcctttttc atccattcca gtggaagaag 8040 tcatttctac aggcataacc tcaggaccag acatcaactc agcacccatg acacattctc 8100 ccatcacccc accaacaatt gtatggacca gtacaggcac aattgaacag tccactcaac 8160 cactacatgc agtttcttca gaaaaagttt ctgtgcagac acagtcaact ccatatgtca 8220 actctgtggc agtgtctgct tcccctaccc atgagaattc agtctcttct ggaagcagca 8280 catcctctcc atattcctca gcctcacttg aatccttgga ttccacaatc agtaggagga 8340 atgcaatcac ttcctggcta tgggacctca ctacatctct ccccactaca acttggccaa 8400 gtactagttt atctgaggca ctgtcctcag gccattctgg ggtttcaaac ccaagttcaa 8460 ctacgactga atttccactc ttttcagctg catccacatc tgctgctaag caaagaaatc 8520 cagaaacaga gacccatggt ccccagaata cagccgcgag tactttgaac actgatgcat 8580 cctcggtcac aggtctttct gagactcctg tgggggcaag tatcagctct gaagtccctc 8640 ttccaatggc cataacttct agatcagatg tttctggcct tacatctgag agtactgcta 8700 acccgagttt aggcacagcc tcttcagcag ggaccaaatt aactaggaca atatccctgc 8760 ccacttcaga gtctttggtt tcctttagaa tgaacaagga tccatggaca gtgtcaatcc 8820 ctttggggtc ccatccaact actaatacag aaacaagcat cccagtaaac agcgcaggtc 8880 cacctggctt gtccacagta gcatcagatg taattgacac accttcagat ggggctgaga 8940 gtattcccac tgtctccttt tccccctccc ctgatactga agtgacaact atctcacatt 9000 tcccagaaaa gacaactcat tcatttagaa ccatttcatc tctcactcat gagttgactt 9060 caagagtgac acctattcct ggggattgga tgagttcagc tatgtctaca aagcccacag 9120 gagccagtcc ctccattaca ctgggagaga gaaggacaat cacctctgct gctccaacca 9180 cttcccccat agttctcact gctagtttca cagagaccag cacagtttca ctggataatg 9240 aaactacagt aaaaacctca gatatccttg acgcacggaa aacaaatgag ctcccctcag 9300 atagcagttc ttcttctgat ctgatcaaca cctccatagc ttcttcaact atggatgtca 9360 ctaaaacagc ctccatcagt cccactagca tctcaggaat gacagcaagt tcctccccat 9420 ctctcttctc ttcagataga ccccaggttc ccacatctac aacagagaca aatacagcca 9480 cctctccatc tgtttccagt aacacctatt ctcttgatgg gggctccaat gtgggtggca 9540 ctccatccac tttaccaccc tttacaatca cccaccctgt cgagacaagc tcggccctat 9600 tagcctggtc tagaccagta agaactttca gcaccatggt cagcactgac actgcctccg 9660 gagaaaatcc tacctctagc aattctgtgg tgacttctgt tccagcacca ggtacatgga 9720 ccagtgtagg cagtactact gacttacctg ccatgggctt tctcaagaca agtcctgcag 9780 gagaggcaca ctcacttcta gcatcaacta ttgaaccagc cactgccttc actccccatc 9840 tctcagcagc agtggtcact ggatccagtg ctacatcaga agccagtctt ctcactacga 9900 gtgaaagcaa agccattcat tcttcaccac agaccccaac tacacccacc tctggagcaa 9960 actgggaaac ttcagctact cctgagagcc ttttggtagt cactgagact tcagacacaa 10020 cacttacctc aaagattttg gtcacagata ccatcttgtt ttcaactgtg tccacgccac 10080 cttctaaatt tccaagtacg gggactctgt ctggagcttc cttccctact ttactcccgg 10140 acactccagc catccctctc actgccactg agccaacaag ttcattagct acatcctttg 10200 attccacccc actggtgact atagcttcgg atagtcttgg cacagtccca gagactaccc 10260 tgaccatgtc agagacctca aatggtgatg cactggttct taagacagta agtaacccag 10320 ataggagcat ccctggaatc actatccaag gagtaacaga aagtccactc catccttctt 10380 ccacttcccc ctctaagatt gttgctccac ggaatacaac ctatgaaggt tcgatcacag 10440 tggcactttc tactttgcct gcgggaacta ctggttccct tgtattcagt cagagttctg 10500 aaaactcaga gacaacggct ttggtagact catcagctgg gcttgagagg gcatctgtga 10560 tgccactaac cacaggaagc cagggtatgg ctagctctgg aggaatcaga agtgggtcca 10620 ctcactcaac tggaaccaaa acattttctt ctctccctct gaccatgaac ccaggtgagg 10680 ttacagccat gtctgaaatc accacgaaca gactgacagc tactcaatca acagcaccca 10740 aagggatacc tgtgaagccc accagtgctg agtcaggcct cctaacacct gtctctgcct 10800 cctcaagccc atcaaaggcc tttgcctcac tgactacagc tcccccaact tgggggatcc 10860 cacagtctac cttgacattt gagttttctg aggtcccaag tttggatact aagtccgctt 10920 ctttaccaac tcctggacag tccctgaaca ccattccaga ctcagatgca agcacagcat 10980 cttcctcact gtccaagtct ccagaaaaaa acccaagggc aaggatgatg acttccacaa 11040 aggccataag tgcaagctca tttcaatcaa caggttttac tgaaacccct gagggatctg 11100 cctccccttc tatggcaggg catgaaccca gagtccccac ttcaggaaca ggggacccta 11160 gatatgcctc agagagcatg tcttatccag acccaagcaa ggcatcatca gctatgacat 11220 cgacctctct tgcatcaaaa ctcacaactc tcttcagcac aggtcaagca gcaaggtctg 11280 gttctagttc ctctcccata agcctatcca ctgagaaaga aacaagcttc ctttccccca 11340 ctgcatccac ctccagaaag acttcactat ttcttgggcc ttccatggca aggcagccca 11400 acatattggt gcatcttcag acttcagctc tgacactttc tccaacatcc actctaaata 11460 tgtcccagga ggagcctcct gagttaacct caagccagac cattgcagaa gaagagggaa 11520 caacagctga aacacagacg ttaaccttca caccatctga gaccccaaca tccttgttac 11580 ctgtctcttc tcccacagaa cccacagcca gaagaaagag ttctccagaa acatgggcaa 11640 gctctatttc agttcctgcc aagacctcct tggttgaaag taagaatgcc ctgctccttc 11700 cccaagtgtg ctggggatga atctggaaat aaactacatc ttttttattt tttaaacttt 11760 tatatttgaa aatataaata ttttaggttc agggaacatg tgcaggtttg ttatataggt 11820 aaattgcatg tcatgggggc ttggggtaca gattacatca tcagccaggt aataagccta 11880 gtacctgatc agtagatttt ttttaatcct ctccctcctc ccagcctcca ccctcaattc 11940 acatgtctcc atgtgtactc aaggtttaat tcccacttat gagtgagaac atgcggtatt 12000 tgtaaactac atctttattt ttgctaacct cgaactgaaa tttagcattt gttttattga 12060 tgaatagagg taacaaaaca aaccacatta atcctagcag tgcctgtgcc tttgccaaca 12120 acagaaattc cggacacttt catatcctat gacaattgtt gcaagcactt ttaaaaatca 12180 tgtacgactt tattcataat tatagtggtt attaggcttt tcaatagatc ttatttaatg 12240 agttagtaaa ataagtgcct gtattattgt attacatttg tttattaaga tcttgataac 12300 aacatttcaa tataatcatt tcctttgttt tttaaatttt agattcaggg gtatatgtgc 12360 aggtttgtta cgtggatata ctgcataatg atgaggtttg gcttctagtg aacccatcag 12420 ccaaatagtg aatgttgtgc ccaataagta gtttttcaat cctcacttca ctcccagcct 12480 cctctatttt ggagtcccag tgtctattat ttctatcttt atgtccacat gtacccattg 12540 gttagctccc acttataagt gagaatgtgc agtatttaat tttctgtttt tgagttattt 12600 tgcttaggtt gatggccttc agctccagcc acgttgcttt aaagaacatg atttcattct 12660 tttttatggc tgcatagtac tccgaggtgt atgtgtacca gattttcttt atccacaatg 12720 atttcctttg taatctaata ttttatattg ttattttatg ttttattcta tatttttatt 12780 ttaatttata aaggaattca tatggttcac aagcctgtca aagggaccta taataaaaag 12840 aggttaagaa tccatgctct aaacagaata ttactccatt ttatttcatt tatttttaaa 12900 gagacagtct cactctgtca tccaggctgg agtacagtgg agtgatcata gctcattgca 12960 accctgaact cttgggcaca agcaattctc ctgcttcatc ctccagagga gctgggacta 13020 caggtgcaca tcaccatgcc cagctagttt taaaaattat tttgtagaga tggtgtctca 13080 ctatcctacc caggctggtc tcaaactcct gggctcaggc aatcctccca ctttgacctc 13140 ccaaagtgtt gagattacag gggcaagcca ctgtgcctgg ccacttgtca cattttaatt 13200 tgtgattact tataaaatga accccttccc atctgagatc tgtcagtctt tctggtgacg 13260 gtgcctggtg tctgctttct accatgtcct gttagactag tgtttgatgg gaggtcacct 13320 gggcagctgt ccagctcact cactgggctc tagagcctct gagttgaagc aaaatagaaa 13380 gatcagtcaa tgtaaagaaa gctcaaaaac tgacattctg aagtaatgga tagctaaacc 13440 ttcctattgc ccttttcttt cagcaactga tggaacgcta gtgaccacca taaagatgtc 13500 aagccaggca gcacaaggaa attccacgtg gcctgcccca gcagaggaga cggggaccag 13560 tccagcaggt aaatatagac cttgtttcca tttctgctct gctaatgcca cccaagcctt 13620 tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcttt ctctcccttt 13680 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ctttctttct 13740 ttctttcttt ctttctttct ttctttcttt ctttctttct ctttctttct tctttctctc 13800 tctctctttc tttctttctc ttgttctttt taaatttttt atttttttac ttaatttttt 13860 tcacccaagc cttaaggcca gtttggacca gatagtgaga ccccacctct ataaaaaaaa 13920 tttttaaaaa aaaaataagt tgggcatcgt gcaggcctgt agtccctgct actcgagagg 13980 ccaaggtggg aggacagctt gctgctgact aaaagtgctg cttattgatt ctgggaagaa 14040 aaaatataca aggcttcagt ttcattattt tataagtaaa tgctagcaac ttttcctttc 14100 tttctctctt tctctcttcc tctctttctc tcctctcctt ctcttctctc tctctctctc 14160 tctctctctc tttctctctc ctctccttct cttctcttct ttctctctct ctctctttca 14220 tttatttttg agacatggtc tcattctgtc acccaggctg gagtacagtg gtgtatattt 14280 actgcagtac tcactgtact cactgcagcc tcaaattcct gggctcaagc tatcctctca 14340 cctcagcctc ctgagtagct gggcagcagt ccagctcact cactgggctc tagagcctct 14400 gtgctatgcc cagcttattg ttgttgtttt tttaaatttt tttttttgta cagatggggt 14460 ctcactatgt ggcccaaggt ggtcttaaac tcctggctcc aagagatcct cccacctcag 14520 cctcccaaag tgcagggatt acaggtgtga gccactgtgc ccagcctaga cagcattttt 14580 tttttttgaa acagggtctc cctctgttgc ccaggctgga gtgcaatggc gtgttcatgg 14640 ttcactgcag cctcagcctc ctcagtctca agcaatcctc caacttcagc ctcccccaac 14700 agctagaact gcaggtgatc atcaccaatt agcctggtta attgtgtgtg tatttcttaa 14760 attttttgta gagatagttc tcactatatt gcttgggctg gtctcaaact cctggactca 14820 agtgattcac ctacctcggc ctccctaagc actgggatta caggcttgag ccaccacacc 14880 cggcaaggac taggttttaa aataggttcc taggctgggt gtggtggctt acgcccgtaa 14940 tcccagcact ttgggaggct gaggtgggcg gatcacgagg tcaggagttt gagaccagcc 15000 tggccaacat agtgaaaccc tgtctctact aaaaatacaa aaaattagct gggcatagtg 15060 gcacacacct gtaatcccag ctactcggga ggctgaggaa ggagaatcac ttgaacctgg 15120 gaggcggagg ttgcagtgag ccgagatcat gccattgctc tccagcctgg gtgacagagc 15180 aagactccat ctaaaaaaaa aaaaaaaagt tcctttgact tcttgacact cttctctgag 15240 gatattgatc atttttcccc aatagatgtt actaattgaa cacttctgtt gcttcaactt 15300 actaatttac atgatcaata gccaattaat tcagcaggag agaatgctac agagtcgatt 15360 ctttctgtac tttcttctgc tccagagtga aggatctttc taaatcagag accatcactg 15420 tgttcacagg gagggcctag gtgaacctga gatggcaaat gttgcgtttg ttctacggaa 15480 gaagggatta tgggttgaag tccttggcag tgccaaattg cttagaaaaa tgtgaaatat 15540 ggtccctagg agtgctcttg ggatgtcaca tttttctcac tcctttgaca ggtagatgtt 15600 attttcctga aggccaggga aaggattcag agggaggaat gaatttgaaa gaaaatgaag 15660 gtgacgagaa agaatgagct catctccctt atcctctttc ttctcaaatc cttaagtagc 15720 tttgcagtga actaagattt gggggaacct agaggaggct gaaagttgga agctgaaatt 15780 ggcttagcaa gggcaagctc caaagacaaa agtggaaata gtttgggggt agccttttgc 15840 atgggtgaaa tcctggttca tcacatcctc ccttatgcaa agagcccttt tatatggggc 15900 atggggaaaa actgagctaa aggtgataat ttctcctgag caagccagat ggtcaaagct 15960 ctaacttcac catctccctt ggaatgttta atgtgttccc tggtgtccag aggcttaacg 16020 tgtgagaatt aaaagctcaa cattttcttt cccagggaag gaggaaatag ttttaattga 16080 aatcccggga ggaaatgaat gatagtgtca aaccaaaaaa cttcatcttc tgtaccactt 16140 gcatatactc cactgactta ctttctaatc acaggcacat ccccaggaag cccagaaatg 16200 tctaccactc tcaaaatcat gagctccaag gaacccggca tcagcccaga gatcaggtcc 16260 actgtgagaa attctccttg gaagactcca gaaacaactg ttcccatgga gaccacagtg 16320 gaaccagtca cccttcagtc cacagcccta ggaagtggca gcaccagcat ctctcacctg 16380 cccacaggaa ccacatcacc aaccaagtca ccaacagaaa atatgttggc tacagaaagg 16440 gtctccctct ccccatcccc acctgaggct tggaccaacc tttattctgg aactccagga 16500 gggaccaggc agtcactggc cacaatgtcc tctgtctccc tagagtcacc aactgctaga 16560 agcatcacag ggactggtca gcaaagcagt ccagaactgg ttttaaagac aactggaatg 16620 gaattctcta tgtggcatgg ctctactgga gggaccacag gggacacaca tgtctctctg 16680 agcacatctt ccaatatcct tgaagaccct gtaaccagcc caaactctgt gagctcattg 16740 acagataaat ccaaacataa aaccgagaca tgggtcagca ccacagccat tccctccact 16800 gtcctgaata ataagataat ggcagctgaa caacagacaa gtcgatctgt ggatgaggct 16860 tattcatcaa ctagttcttg gtcagatcag acatctggga gtgacatcac ccttggtgca 16920 tctcctgatg tcacaaacac attatacatc acctccacag cacaaaccac ctcactagta 16980 tctctgccct ctggagacca aggcattaca agcctcacca atccctcagg aggaaaaaca 17040 agctctgcat catctgtcac atctccttca atagggcttg agactctgat ggccaatgta 17100 agtgcagtga caagtgacat tgcccctact gctgggcatc tatctcagac ttcatctcct 17160 gcggaagtga gcatcctgga cataaccaca gctcctactc caggtatctc caccaccatc 17220 accaccatgg gaaccaactc aatctcaact accacaccca acccagaagt gggtatgagt 17280 accatggaca gcaccccggc cacagagagg cacacaactt ctacagaaca cccttccacc 17340 tggtcttcca cagctgcatc agattcctgg actgtcacag acatgacttc aaacttgaaa 17400 gttgcaagat ctcctggaac aatttccaca atgcatacaa cttcattctt agcctcaagc 17460 actgaattag actccatgtc tactccccat ggccgtataa ctgtcattgg aaccagcctg 17520 gtcactccat cctctgatgc ttcagctgta aagacagaga ccagtacaag tgaaagaaca 17580 ttgagtcctt cagacacaac tgcatctact cccatctcaa ctttttctcg tgtccagagg 17640 atgagcatct cagttcctga cattttaagt acaagttgga ctcccagtag tacagaagca 17700 gaagatgtgc ctgtttcaat ggtttctaca gatcatgcta gtacaaagac tgacccaaat 17760 atgcccctgt ccacttttct gtttgattct ctgtccactc ttgactggga cactgggaga 17820 tctctgtcat cagccacagc cactacctca gctcctcagg gggccacaac tccccaagaa 17880 ctcactttgg aaaccatgat cagcccagct acctcacagt tgcccttctc tatagggcac 17940 attacaagtg cagtcatacc agctgcaatg gcaaggagct ctggagttac tttttcaaga 18000 ccagatccca caagcaaaaa ggcagagcag acttccactc agcttcccac caccacttct 18060 gcacatccag agcaggtgcc cagatcagca gcaacaactc tggatgtgat cccacacaca 18120 gcaaaaactc cagatgcaac ttttcagaga caagggcaga cagctcttac aacagaggca 18180 agagctacat ctgactcctg gaatgagaaa gaaaaatcaa ccccaagtgc accttggatc 18240 actgagatga tgaattctgt ctcagaagat accatcaagg aggttaccag ctcctccagt 18300 gtgttaagga ccctgaatac gctggacata aacttggaat ctgggacgac ttcatcccca 18360 agttggaaaa gcagcccata tgagagaatt gccccttctg agtctaccac agacaaagag 18420 gcaattcacc cttctacaaa cacagtagag accactggct gggtcacaag ttccgaacat 18480 gcttctcatt ccactatccc agcccactca gcgtcatcca aactcacatc tccagtggtt 18540 acaacctcca ccagggaaca agcaatagtt tctatgtcaa caaccacatg gccagagtct 18600 acaagggcta gaacagagcc taattccttc ttgactattg aactgaggga cgtcagccct 18660 tacatggaca ccagctcaac cacacaaaca agttttatct cttccccagg ttccactgcg 18720 atcaccaagg ggcctagaac agaaattacc tcctctaaga gaatatccag ctcattcctt 18780 gcccagtcta tgaggtcgtc agacagcccc tcagaagcca tctccaggct gtctaacttt 18840 cctgccatga cagaatctgg aggaatgatc cttgctatgc aaacaagtcc acctggcgct 18900 acatcactaa gtgcacctac tttggataca tcagccacag cctcctggac agggactcca 18960 ctggctacga ctcagagatt tacatactca gagaagacca ctctctttag caaaggtcct 19020 gaggatacat cacagccaag ccctccctct gtggaagaaa ccagctcttc ctcttccctg 19080 gtacctatca atgctacaac ctcgccttcc aatattttgt tgacatcaca agggcacagt 19140 ccctcctcta ctccacctgt gacctcagtt ttcttgtctg agacctctgg cctggggaag 19200 accacagaca tgtcgaggat aagcttggaa cctggcacaa gtttacctcc caatttgagc 19260 agtacagcag gtgaggcgtt atccacttat gaagcctcca gagatacaaa ggcaattcat 19320 cattctgcag acacagcagt gacgaatatg gaggcaacca gttctgaata ttctcctatc 19380 ccaggccata caaagccatc caaagccaca tctccattgg ttacctccca catcatgggg 19440 gacatcactt cttccacatc agtatttggc tcctccgaga ccacagagat tgagacagtg 19500 tcctctgtga accagggact tcaggagaga agcacatccc aggtggccag ctctgctaca 19560 gagacaagca ctgtcattac ccatgtgtct agtggtgatg ctactactca tgtcaccaag 19620 acacaagcca ctttctctag cggaacatcc atctcaagcc ctcatcagtt tataacttct 19680 accaacacat ttacagatgt gagcaccaac ccctccacct ctctgataat gacagaatct 19740 tcaggagtga ccatcaccac ccaaacaggt cctactggag ctgcaacaca gggtccatat 19800 ctcttggaca catcaaccat gccttacttg acagagactc cattagctgt gactccagat 19860 tttatgcaat cagagaagac cactctcata agcaaaggtc ccaaggatgt gtcctggaca 19920 agccctccct ctgtggcaga aaccagctat ccctcttccc tgacaccttt cttggtcaca 19980 accatacctc ctgccacttc cacgttacaa gggcaacata catcctctcc tgtttctgcg 20040 acttcagttc ttacctctgg actggtgaag accacagata tgttgaacac aagcatggaa 20100 cctgtgacca attcacctca aaatttgaac aatccatcaa atgagatact ggccactttg 20160 gcagccacca cagatataga gactattcat ccttccataa acaaagcagt gaccaatatg 20220 gggactgcca gttcagcaca tgtactgcat tccactctcc cagtcagctc agaaccatct 20280 acagccacat ctccaatggt tcctgcctcc agcatggggg acgctcttgc ttctatatca 20340 atacctggtt ctgagaccac agacattgag ggagagccaa catcctccct gactgctgga 20400 cgaaaagaga acagcaccct ccaggagatg aactcaacta cagagtcaaa catcatcctc 20460 tccaatgtgt ctgtgggggc tattactgaa gccacaaaaa tggaagtccc ctcttttgat 20520 gcaacattca taccaactcc tgctcagtca acaaagttcc cagatatttt ctcagtagcc 20580 agcagtagac tttcaaactc tcctcccatg acaatatcta cccacatgac caccacccag 20640 acagggtctt ctggagctac atcaaagatt ccacttgcct tagacacatc aaccttggaa 20700 acctcagcag ggactccatc agtggtgact gaggggtttg cccactcaaa aataaccact 20760 gcaatgaaca atgatgtcaa ggacgtgtca cagacaaacc ctccctttca ggatgaagcc 20820 agctctccct cttctcaagc acctgtcctt gtcacaacct taccttcttc tgttgctttc 20880 acaccgcaat ggcacagtac ctcctctcct gtttctatgt cctcagttct tacttcttca 20940 ctggtaaaga ccgcaggcaa ggtggataca agcttagaaa cagtgaccag ttcacctcaa 21000 agtatgagca acactttgga tgacatatcg gtcacttcag cagccaccac agatatagag 21060 acaacgcatc cttccataaa cacagtagtt accaatgtgg ggaccaccgg ttcagcattt 21120 gaatcacatt ctactgtctc agcttaccca gagccatcta aagtcacatc tccaaatgtt 21180 accacctcca ccatggaaga caccacaatt tccagatcaa tacctaaatc ctctaagact 21240 acaagaactg agactgagac aacttcctcc ctgactccta aactgaggga gaccagcgtc 21300 tcccaggaga tcacctcgtc cacagagaca agcactgttc cttacaaaga gctcactggt 21360 gccactaccg aggtatccag gacagatgtc acttcctcta gcagtacatc cttccctggc 21420 cctgatcagt ccacagtgtc actagacatc tccacagaaa ccaacaccag gctgtctacc 21480 tccccaataa tgacagaatc tgcagaaata accatcacca cccaaacagg tcctcatggg 21540 gctacatcac aggatacttt taccatggac ccatcaaata caacccccca ggcagggatc 21600 cactcagcta tgactcatgg attttcacaa ttggatgtga ccactcttat gagcagaatt 21660 ccacaggatg tatcatggac aagtcctccc tctgtggata aaaccagctc cccctcttcc 21720 tttctgccct cacctgcaat gaccacacct tccctgattt cttctacctt accagaggat 21780 aagctctcct ctcctatgac ttcacttctc acctctggcc tagtgaagat tacagacata 21840 ttacgtacac gcttggaacc tgtgaccagc tcacttccaa atttcagcag cacctcagat 21900 aagatactgg ccacttctaa agacagtaaa gacacaaagg aaatttttcc ttctataaac 21960 acagaagaga ccaatgtgaa agccaacaac tctggacatg aatcccattc ccctgcactg 22020 gctgactcag agacacccaa agccacaact caaatggtta tcaccaccac tgtgggagat 22080 ccagctcctt ccacatcaat gccagtgcat ggttcctctg agactacaaa cattaagaga 22140 gagccaacat atttcttgac tcctagactg agagagacca gtacctctca ggagtccagc 22200 tttcccacgg acacaagttt tctactttcc aaagtcccca ctggtactat tactgaggtc 22260 tccagtacag gggtcatctc ttctagcaaa atttccaccc cagaccatga taagtccaca 22320 gtgccacctg acaccttcac aggagagatc cccagggtct tcacctcctc tattaagaca 22380 aaatctgcag aaatgacgat caccacccaa gcaagtcctc ctgagtctgc atcgcacagt 22440 acccttccct tggacacatc aaccacactt tcccagggag ggactcattc aactgtgact 22500 cagggattcc catactcaga ggtgaccact ctcatgggca tgggtcctgg gaatgtgtca 22560 tggatgacaa ctccccctgt ggaagaaacc agctctgtgt cttccctgat gtcttcacct 22620 gccatgacat ccccttctcc tgtttcctcc acatcaccac agagcatccc ctcctctcct 22680 cttcctgtga ctgcacttcc tacttctgtt ctggtgacaa ccacagatgt gttgggcaca 22740 acaagcccag agtctgtaac cagttcacct ccaaatttga gcagcatcac tcatgagaga 22800 ccggccactt acaaagacac tgcacacaca gaagccgcca tgcatcattc cacaaacacc 22860 gcagtgacca atgtagggac ttccgggtct ggacataaat cacaatcctc tgtcctagct 22920 gactcagaga catcgaaagc cacacctctg atgagtacca cctccaccct gggggacaca 22980 agtgtttcca catcaactcc taatatctct cagactaacc aaattcaaac agagccaaca 23040 gcatccctga gccctagact gagggagagc agcacgtctg agaagaccag ctcaacaaca 23100 gagacaaata ctgccttttc ttatgtgccc acaggtgcta ttactcaggc ctccagaaca 23160 gaaatctcct ctagcagaac atccatctca gaccttgatc ggtccacaat agcacccgac 23220 atctccacag gaatgatcac caggctcttc acctccccca tcatgacaaa atctgcagaa 23280 atgaccgtca ccactcaaac aactactcct ggggctacat cacagggtat ccttccctgg 23340 gacacatcaa ccacactttt ccagggaggg actcattcaa ccgtgtctca gggattccca 23400 cactcagaga taaccactct tcggagcaga acccctggag atgtgtcatg gatgacaact 23460 ccccctgtgg aagaaaccag ctctgggttt tccctgatgt caccttccat gacatcccct 23520 tctcctgttt cctccacatc accagagagc atcccctcct ctcctctccc tgtgactgca 23580 cttcttactt ctgttctggt gacaaccaca aatgtattgg gcacaacaag cccagagccc 23640 gtaacgagtt cacctccaaa tttaagcagc cccacacagg agagactgac cacttacaaa 23700 gacactgcgc acacagaagc catgcatgct tccatgcata caaacactgc agtggccaac 23760 gtggggacct ccatttctgg acatgaatca caatcttctg tcccagctga ttcagacaca 23820 tccaaagcca catctccaat gggtaccacc ttcgccatgg gggatacaag tgtttctaca 23880 tcaactcctg ccttctttga gactagaatt cagactgaat caacatcctc tttgattcct 23940 ggattaaggg acaccaggac gtctgaggag atcaacactg tgacagagac cagcactgtc 24000 ctttcagaag tgcccactac tactactact gaggtctcca ggacagaagt tatcacttcc 24060 agcagaacaa ccatctcagg gcctgatcat tccaaaatgt caccctacat ctccacagaa 24120 accatcacca ggctctccac ttttcctttt gtaacaggat ccacagaaat ggccatcacc 24180 aaccaaacag gtcctatagg gactatctca caggctaccc ttaccctgga cacatcaagc 24240 acagcttcct gggaagggac tcactcacct gtgactcaga gatttccaca ctcagaggag 24300 accactacta tgagcagaag tactaagggc gtgtcatggc aaagccctcc ctctgtggaa 24360 gaaaccagtt ctccttcttc cccagtgcct ttacctgcaa taacctcaca ttcatctctt 24420 tattccgcag tatcaggaag tagccccact tctgctctcc ctgtgacttc ccttctcacc 24480 tctggcagga ggaagaccat agacatgttg gacacacact cagaacttgt gaccagctcc 24540 ttaccaagtg caagtagctt ctcaggtgag atactcactt ctgaagcctc cacaaataca 24600 gagacaattc acttttcaga gaacacagca gaaaccaata tggggaccac caattctatg 24660 cataaactac attcctctgt ctcaatccac tcccagccat ccggacacac acctccaaag 24720 gttactggat ctatgatgga ggacgctatt gtttccacat caacacctgg ttctcctgag 24780 actaaaaatg ttgacagaga ctcaacatcc cctctgactc ctgaactgaa agaggacagc 24840 accgccctgg tgatgaactc aactacagag tcaaacactg ttttctccag tgtgtccctg 24900 gatgctgcta ctgaggtctc cagggcagaa gtcacctact atgatcctac attcatgcca 24960 gcttctgctc agtcaacaaa gtccccagac atttcacctg aagccagcag cagtcattct 25020 aactctcctc ccttgacaat atctacacac aagaccatcg ccacacaaac aggtccttct 25080 ggggtgacat ctcttggcca actgaccctg gacacatcaa ccatagccac ctcagcagga 25140 actccatcag ccagaactca ggattttgta gattcagaaa caaccagtgt catgaacaat 25200 gatctcaatg atgtgttgaa gacaagccct ttctctgcag aagaagccaa ctctctctct 25260 tctcaggcac ctctccttgt gacaacctca ccttctcctg taacttccac attgcaagag 25320 cacagtacct cctctcttgt ttctgtgacc tcagtaccca cccctacact ggcgaagatc 25380 acagacatgg acacaaactt agaacctgtg actcgttcac ctcaaaattt aaggaacacc 25440 ttggccactt cagaagccac cacagataca cacacaatgc atccttctat aaacacagca 25500 gtggccaatg tggggaccac cagttcacca aatgaattct attttactgt ctcacctgac 25560 tcagacccat ataaagccac atccgcagta gttatcactt ccacctcggg ggactcaata 25620 gtttccacat caatgcctag atcctctgcg atgaaaaaga ttgagtctga gacaactttc 25680 tccctgatat ttagactgag ggagactagc acctcccaga aaattggctc atcctcagac 25740 acaagcacgg tctttgacaa agcattcact gctgctacta ctgaggtctc cagaacagaa 25800 ctcacctcct ctagcagaac atccatccaa ggcactgaaa agcccacaat gtcaccggac 25860 acctccacaa gatctgtcac catgctttct acttttgctg gcctgacaaa atccgaagaa 25920 aggaccattg ccacccaaac aggtcctcat agggcgacat cacagggtac ccttacctgg 25980 gacacatcaa tcacaacctc acaggcaggg acccactcag ctatgactca tggattttca 26040 caattagatt tgtccactct tacgagtaga gttcctgagt acatatcagg gacaagccca 26100 ccctctgtgg aaaaaaccag ctcttcctct tcccttctgt ctttaccagc aataacctca 26160 ccgtcccctg tacctactac attaccagaa agtaggccgt cttctcctgt tcatctgact 26220 tcactcccca cctctggcct agtgaagacc acagatatgc tggcatctgt ggccagttta 26280 cctccaaact tgggcagcac ctcacataag ataccgacta cttcagaaga cattaaagat 26340 acagagaaaa tgtatccttc cacaaacata gcagtaacca atgtggggac caccacttct 26400 gaaaaggaat cttattcgtc tgtcccagcc tactcagaac cacccaaagt cacctctcca 26460 atggttacct ctttcaacat aagggacacc attgtttcca catccatgcc tggctcctct 26520 gagattacaa ggattgagat ggagtcaaca ttctccctgg ctcatgggct gaagggaacc 26580 agcacctccc aggaccccat cgtatccaca gagaaaagtg ctgtccttca caagttgacc 26640 actggtgcta ctgagacctc taggacagaa gttgcctctt ctagaagaac atccattcca 26700 ggccctgatc attccacaga gtcaccagac atctccactg aagtgatccc cagcctgcct 26760 atctcccttg gcattacaga atcttcaaat atgaccatca tcactcgaac aggtcctcct 26820 cttggctcta catcacaggg cacatttacc ttggacacac caactacatc ctccagggca 26880 ggaacacact cgatggcgac tcaggaattt ccacactcag aaatgaccac tgtcatgaac 26940 aaggaccctg agattctatc atggacaatc cctccttcta tagagaaaac cagcttctcc 27000 tcttccctga tgccttcacc agccatgact tcacctcctg tttcctcaac attaccaaag 27060 accattcaca ccactccttc tcctatgacc tcactgctca cccctagcct agtgatgacc 27120 acagacacat tgggcacaag cccagaacct acaaccagtt cacctccaaa tttgagcagt 27180 acctcacatg agatactgac aacagatgaa gacaccacag ctatagaagc catgcatcct 27240 tccacaagca cagcagcgac taatgtggaa accaccagtt ctggacatgg gtcacaatcc 27300 tctgtcctag ctgactcaga aaaaaccaag gccacagctc caatggatac cacctccacc 27360 atggggcata caactgtttc cacatcaatg tctgtttcct ctgagactac aaaaattaag 27420 agagagtcaa catattcctt gactcctgga ctgagagaga ccagcatttc ccaaaatgcc 27480 agcttttcca ctgacacaag tattgttctt tcagaagtcc ccactggtac tactgctgag 27540 gtctccagga cagaagtcac ctcctctggt agaacatcca tccctggccc ttctcagtcc 27600 acagttttgc cagaaatatc cacaagaaca atgacaaggc tctttgcctc gcccaccatg 27660 acagaatcag cagaaatgac catccccact caaacaggtc cttctgggtc tacctcacag 27720 gataccctta ccttggacac atccaccaca aagtcccagg caaagactca ttcaactttg 27780 actcagagat ttccacactc agagatgacc actctcatga gcagaggtcc tggagatatg 27840 tcatggcaaa gctctccctc tctggaaaat cccagctctc tcccttccct gctgtcttta 27900 cctgccacaa cctcacctcc tcccatttcc tccacattac cagtgactat ctcctcctct 27960 cctcttcctg tgacttcact tctcacctct agcccggtaa cgaccacaga catgttacac 28020 acaagcccag aacttgtaac cagttcacct ccaaagctga gccacacttc agatgagaga 28080 ctgaccactg gcaaggacac cacaaataca gaagctgtgc atccttccac aaacacagca 28140 gcgtccaatg tggagattcc cagctctgga catgaatccc cttcctctgc cttagctgac 28200 tcagagacat ccaaagccac atcaccaatg tttattacct ccacccagga ggatacaact 28260 gttgccatat caacccctca cttcttggag actagcagaa ttcagaaaga gtcaatttcc 28320 tccctgagcc ctaaattgag ggagacaggc agttctgtgg agacaagctc agccatagag 28380 acaagtgctg tcctttctga agtgtccgtt ggtgctacta ctgagatctc caggacagaa 28440 gtcacctcct ctagcagaac atccatctct ggttctgctg agtccacaat gttgccagaa 28500 atatccacca caagaaaaat cattaagttc cctacttccc ccatcctggc agaatcatca 28560 gaaatgacca tcaagaccca aacaagtcct cctgggtcta catcagagag tacctttaca 28620 ttagacacat caaccactcc ctccttggta ataacccatt cgactatgac tcagagattg 28680 ccacactcag agataaccac tcttgtgagt agaggtgctg gggatgtgcc acggcccagc 28740 tctctccctg tggaagaaac aagccctcca tcttcccagc tgtctttatc tgccatgatc 28800 tcaccttctc ctgtttcttc cacattacca gcaagtagcc actcctcttc tgcttctgtg 28860 acttcacttc tcacaccagg ccaagtgaag actactgagg tgttggacgc aagtgcagaa 28920 cctgaaacca gttcacctcc aagtttgagc agcacctcag ttgaaatact ggccacctct 28980 gaagtcacca cagatacgga gaaaattcat cctttctcaa acacggcagt aaccaaagtt 29040 ggaacttcca gttctggaca tgaatcccct tcctctgtcc tacctgactc agagacaacc 29100 aaagccacat cggcaatggg taccatctcc attatggggg atacaagtgt ttctacatta 29160 actcctgcct tatctaacac taggaaaatt cagtcagagc cagcttcctc actgaccacc 29220 agattgaggg agaccagcac ctctgaagag accagcttag ccacagaagc aaacactgtt 29280 ctttctaaag tgtccactgg tgctactact gaggtctcca ggacagaagc catctccttt 29340 agcagaacat ccatgtcagg ccctgagcag tccacaatgt cacaagacat ctccatagga 29400 accatcccca ggatttctgc ctcctctgtc ctgacagaat ctgcaaaaat gaccatcaca 29460 acccaaacag gtccttcgga gtctacacta gaaagtaccc ttaatttgaa cacagcaacc 29520 acaccctctt gggtggaaac ccactctata gtaattcagg gatttccaca cccagagatg 29580 accacttcca tgggcagagg tcctggaggt gtgtcatggc ctagccctcc ctttgtgaaa 29640 gaaaccagcc ctccatcctc cccgctgtct ttacctgccg tgacctcacc tcatcctgtt 29700 tccaccacat tcctagcaca tatccccccc tctccccttc ctgtgacttc acttctcacc 29760 tctggcccgg cgacaaccac agatatcttg ggtacaagca cagaacctgg aaccagttca 29820 tcttcaagtt tgagcaccac ctcccatgag agactgacca cttacaaaga cactgcacat 29880 acagaagccg tgcatccttc cacaaacaca ggagggacca atgtggcaac caccagctct 29940 ggatataaat cacagtcctc tgtcctagct gactcatctc caatgtgtac cacctccacc 30000 atgggggata caagtgttct cacatcaact cctgccttcc ttgagactag gaggattcag 30060 acagagctag cttcctccct gacccctgga ttgagggagt ccagtggctc tgaagggacc 30120 agctcaggca ccaagatgag cactgtcctc tctaaagtgc ccactggtgc tactactgag 30180 atctccaagg aagacgtcac ctccatccca ggtcccgctc aatccacaat atcaccagac 30240 atctccacaa gaaccgtcag ctggttctct acatcccctg tcatgacaga atcagcagaa 30300 ataaccatga acacccatac aagtccttta ggggccacaa cacaaggcac cagtactttg 30360 gccacgtcaa gcacaacctc tttgacaatg acacactcaa ctatatctca aggattttca 30420 cactcacaga tgagcactct tatgaggagg ggtcctgagg atgtatcatg gatgagccct 30480 ccccttctgg aaaaaactag accttccttt tctctgatgt cttcaccagc cacaacttca 30540 ccttctcctg tttcctccac attaccagag agcatctctt cctctcctct tcctgtgact 30600 tcactcctca cgtctggctt ggcaaaaact acagatatgt tgcacaaaag ctcagaacct 30660 gtaaccaact cacctgcaaa tttgagcagc acctcagttg aaatactggc cacctctgaa 30720 gtcaccacag atacagagaa aactcatcct tcttcaaaca gaacagtgac cgatgtgggg 30780 acctccagtt ctggacatga atccacttcc tttgtcctag ctgactcaca gacatccaaa 30840 gtcacatctc caatggttat tacctccacc atggaggata cgagtgtctc cacatcaact 30900 cctggctttt ttgagactag cagaattcag acagaaccaa catcctccct gacccttgga 30960 ctgagaaaga ccagcagctc tgaggggacc agcttagcca cagagatgag cactgtcctt 31020 tctggagtgc ccactggtgc cactgctgaa gtctccagga cagaagtcac ctcctctagc 31080 agaacatcca tctcaggctt tgctcagctc acagtgtcac cagagacttc cacagaaacc 31140 atcaccagac tccctacctc cagcataatg acagaatcag cagaaatgat gatcaagaca 31200 caaacagatc ctcctgggtc tacaccagag agtactcata ctgtggacat atcaacaaca 31260 cccaactggg tagaaaccca ctcgactgtg actcagagat tttcacactc agagatgacc 31320 actcttgtga gcagaagccc tggtgatatg ttatggccta gtcaatcctc tgtggaagaa 31380 accagctctg cctcttccct gctgtctctg cctgccacga cctcaccttc tcctgtttcc 31440 tctacattag tagaggattt cccttccgct tctcttcctg tgacttctct tctcacccct 31500 ggcctggtga taaccacaga caggatgggc ataagcagag aacctggaac cagttccact 31560 tcaaatttga gcagcacctc ccatgagaga ctgaccactt tggaagacac tgtagataca 31620 gaagacatgc agccttccac acacacagca gtgaccaacg tgaggacctc catttctgga 31680 catgaatcac aatcttctgt cctatctgac tcagagacac ccaaagccac atctccaatg 31740 ggtaccacct acaccatggg ggaaacgagt gtttccatat ccacttctga cttctttgag 31800 accagcagaa ttcagataga accaacatcc tccctgactt ctggattgag ggagaccagc 31860 agctctgaga ggatcagctc agccacagag ggaagcactg tcctttctga agtgcccagt 31920 ggtgctacca ctgaggtctc caggacagaa gtgatatcct ctaggggaac atccatgtca 31980 gggcctgatc agttcaccat atcaccagac atctctactg aagcgatcac caggctttct 32040 acttccccca ttatgacaga atcagcagaa agtgccatca ctattgagac aggttctcct 32100 ggggctacat cagagggtac cctcaccttg gacacctcaa caacaacctt ttggtcaggg 32160 acccactcaa ctgcatctcc aggattttca cactcagaga tgaccactct tatgagtaga 32220 actcctggag atgtgccatg gccgagcctt ccctctgtgg aagaagccag ctctgtctct 32280 tcctcactgt cttcacctgc catgacctca acttcttttt tctccacatt accagagagc 32340 atctcctcct ctcctcatcc tgtgactgca cttctcaccc ttggcccagt gaagaccaca 32400 gacatgttgc gcacaagctc agaacctgaa accagttcac ctccaaattt gagcagcacc 32460 tcagctgaaa tattagccac gtctgaagtc accaaagata gagagaaaat tcatccctcc 32520 tcaaacacac ctgtagtcaa tgtagggact gtgatttata aacatctatc cccttcctct 32580 gttttggctg acttagtgac aacaaaaccc acatctccaa tggctaccac ctccactctg 32640 gggaatacaa gtgtttccac atcaactcct gccttcccag aaactatgat gacacagcca 32700 acttcctccc tgacttctgg attaagggag atcagtacct ctcaagagac cagctcagca 32760 acagagagaa gtgcttctct ttctggaatg cccactggtg ctactactaa ggtctccaga 32820 acagaagccc tctccttagg cagaacatcc accccaggtc ctgctcaatc cacaatatca 32880 ccagaaatct ccacggaaac catcactaga atttctactc ccctcaccac gacaggatca 32940 gcagaaatga ccatcacccc caaaacaggt cattctgggg catcctcaca aggtaccttt 33000 accttggaca catcaagcag agcctcctgg ccaggaactc actcagctgc aactcacaga 33060 tctccacact cagggatgac cactcctatg agcagaggtc ctgaggatgt gtcatggcca 33120 agccgcccat cagtggaaaa aactagccct ccatcttccc tggtgtcttt atctgcagta 33180 acctcacctt cgccacttta ttccacacca tctgagagta gccactcatc tcctctccgg 33240 gtgacttctc ttttcacccc tgtcatgatg aagaccacag acatgttgga cacaagcttg 33300 gaacctgtga ccacttcacc tcccagtatg aatatcacct cagatgagag tctggccact 33360 tctaaagcca ccatggagac agaggcaatt cagctttcag aaaacacagc tgtgactcag 33420 atgggcacca tcagcgctag acaagaattc tattcctctt atccaggcct cccagagcca 33480 tccaaagtga catctccagt ggtcacctct tccaccataa aagacattgt ttctacaacc 33540 atacctgctt cctctgagat aacaagaatt gagatggagt caacatccac cctgaccccc 33600 acaccaaggg agaccagcac ctcccaggag atccactcag ccacaaagcc aagcactgtt 33660 ccttacaagg cactcactag tgccacgatt gaggactcca tgacacaagt catgtcctct 33720 agcagaggac ctagccctga tcagtccaca atgtcacaag acatatccag tgaagtgatc 33780 accaggctct ctacctcccc catcaaggca gaatctacag aaatgaccat taccacccaa 33840 acaggttctc ctggggctac atcaaggggt acccttacct tggacacttc aacaactttt 33900 atgtcaggga cccactcaac tgcatctcaa ggattttcac actcacagat gaccgctctt 33960 atgagtagaa ctcctggaga tgtgccatgg ctaagccatc cctctgtgga agaagccagc 34020 tctgcctctt tctcactgtc ttcacctgtc atgacctcat cttctcccgt ttcttccaca 34080 ttaccagaca gcatccactc ttcttcgctt cctgtgacat cacttctcac ctcagggctg 34140 gtgaagacca cagagctgtt gggcacaagc tcagaacctg aaaccagttc acccccaaat 34200 ttgagcagca cctcagctga aatactggcc accactgaag tcactacaga tacagagaaa 34260 ctggagatga ccaatgtggt aacctcaggt tatacacatg aatctccttc ctctgtccta 34320 gctgactcag tgacaacaaa ggccacatct tcaatgggta tcacctaccc cacaggagat 34380 acaaatgttc tcacatcaac ccctgccttc tctgacaccn nnnnnnnnnn nnnnnnnnnn 34440 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 34500 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncggaaa ccaagtttct aaccaacccc 34560 tcctttttga ccccagtagg attcaaacaa agtcaaagct ctcactgact cctgggttga 34620 tggagaccag catctctgaa gagaccagct ctgccacaga aaaaagcact gtcctttcta 34680 gtgtgcccac tggtgctact actgaggtct ccaggacaga agccatctct tctagcagaa 34740 catccatccc aggccctgct caatccacaa tgtcatcaga cacctccatg gaaaccatca 34800 ctagaatttc tacccccctc acaaggaaag aatcaacaga catggccatc acccccaaaa 34860 caggtccttc tggggctacc tcgcagggta cctttacctt ggactcatca agcacagcct 34920 cctggccagg aactcactca gctacaactc agagatttcc acagtcagtg gtgacaactc 34980 ctatgagcag aggtcctgag gatgtgtcat ggccaagccc gctgtctgtg gaaaaaaaca 35040 gccctccatc ttccctggta tcttcatctt cagtaacctc accttcgcca ctttattcca 35100 caccatctgg gagtagccac tcctctcctg tccctgtcac ttctcttttc acctctatca 35160 tgatgaaggc cacagacatg ttggatgcaa gtttggaacc tgagaccact tcagctccca 35220 atatgaatat cacctcagat gagagtctgg ccacttctaa agccaccacg gagacagagg 35280 caattcacgt ttttgaaaat acagcagcgt cccatgtgga aaccaccagt gctacagagg 35340 aactctattc ctcttcccca ggcttctcag agccaacaaa agtgatatct ccagtggtca 35400 cctcttcctc tataagagac aacatggttt ccacaacaat gcctggctcc tctggcatta 35460 caaggattga gatagagtca atgtcatctc tgacccctgg actgagggag accagaacct 35520 cccaggacat cacctcatcc acagagacaa gcactgtcct ttacaagatg tcctctggtg 35580 ccactcctga ggtctccagg acagaagtta tgccctctag cagaacatcc attcctggcc 35640 ctgctcagtc cacaatgtca ctagacatct ccgatgaagt tgtcaccagg ctgtctacct 35700 ctcccatcat gacagaatct gcagaaataa ccatcaccac ccaaacaggt tattctctgg 35760 ctacatccca ggttaccctt cccttgggca cctcaatgac ctttttgtca gggacccact 35820 caactatgtc tcaaggactt tcacactcag agatgaccaa tcttatgagc aggggtcctg 35880 aaagtctgtc atggacgagc cctcgctttg tggaaacaac tagatcttcc tcttctctga 35940 catcattacc tctcacgacc tcactttctc ctgtgtcctc cacattacta gacagtagcc 36000 cctcctctcc tcttcctgtg acttcactta tcctcccagg cctggtgaag actacagaag 36060 tgttggatac aagctcagag cctaaaacca gttcatctcc aaatttgagc agcacctcag 36120 ttgaaatacc ggccacctct gaaatcatga cagatacaga gaaaattcat ccttcctcaa 36180 acacagcggt ggccaaagtg aggacctcca gttctgttca tgaatctcat tcctctgtcc 36240 tagctgactc agaaacaacc ataaccatac cttcaatggg tatcacctcc gctgtggacg 36300 ataccactgt tttcacatca aatcctgcct tctctgagac taggaggatt ccgacagagc 36360 caacattctc attgactcct ggattcaggg agactagcac ctctgaagag accacctcaa 36420 tcacagaaac aagtgcagtc ctttatggag tgcccactag tgctactact gaagtctcca 36480 tgacagaaat catgtcctct aatagaacac acatccctga ctctgatcag tccacgatgt 36540 ctccagacat catcactgaa gtgatcacca ggctctcttc ctcatccatg atgtcagaat 36600 caacacaaat gaccatcacc acccaaaaaa gttctcctgg ggctacagca cagagtactc 36660 ttaccttggc cacaacaaca gcccccttgg caaggaccca ctcaactgtt cctcctagat 36720 ttttacactc agagatgaca actcttatga gtaggagtcc tgaaaatcca tcatggaaga 36780 gctctccctt tgtggaaaaa actagctctt catcttctct gttgtcctta cctgtcacga 36840 cctcaccttc tgtttcttcc acattaccgc agagtatccc ttcctcctct ttttctgtga 36900 cttcactcct caccccaggc atggtgaaga ctacagacac aagcacagaa cctggaacca 36960 gtttatctcc aaatctgagt ggcacctcag ttgaaatact ggctgcctct gaagtcacca 37020 cagatacaga gaaaattcat ccttcttcaa gcatggcagt gaccaatgtg ggaaccacca 37080 gttctggaca tgaactatat tcctctgttt caatccactc ggagccatcc aaggctacat 37140 acccagtggg tactccctct tccatggctg aaacctctat ttccacatca atgcctgcta 37200 attttgagac cacaggattt gaggctgagc cattttctca tttgacttct ggatttagga 37260 agacaaacat gtccctggac accagctcag tcacaccaac aaatacacct tcttctcctg 37320 ggtccactca ccttttacag agttccaaga ctgatttcac ctcttctgca aaaacatcat 37380 ccccagactg gcctccagcc tcacagtata ctgaaattcc agtggacata atcaccccct 37440 ttaatgcttc tccatctatt acggagtcca ctgggataac ctccttccca gaatccaggt 37500 ttactatgtc tgtaacagaa agtactcatc atctgagtac agatttgctg ccttcagctg 37560 agactatttc cactggcaca gtgatgcctt ctctatcaga ggccatgact tcatttgcca 37620 ccactggagt tccacgagcc atctcaggtt caggtagtcc attctctagg acagagtcag 37680 gccctgggga tgctactctg tccaccattg cagagagcct gccttcatcc actcctgtgc 37740 cattctcctc ttcaaccttc actaccactg attcttcaac catcccagcc ctccatgaga 37800 taacttcctc ttcagctacc ccatatagag tggacaccag tcttgggaca gagagcagca 37860 ctactgaagg acgcttggtt atggtcagta ctttggacac ttcaagccaa ccaggcagga 37920 catcttcaac acccattttg gataccagaa tgacagagag cgttgagctg ggaacagtga 37980 caagtgctta tcaagttcct tcactctcaa cacggttgac aagagaatgc gcatggcgag 38040 aagggagaag tgtagttgga tggataaaag gaagaatgga gagaagagtg aatggaagga 38100 agcaaagatg aagcggagga aggatagatg cacagaagga aggatgaaaa gaaagaaaga 38160 tgatggaaga caggattgaa ggggatatag attgaaggaa agaaaggtag aaggatgaaa 38220 tgaagtaaag attgaagaaa agatggatgg aaagaagaaa ggagggtgca caaaaaatct 38280 cacacttcac cacatatgat tcatccatat aagaaaaaac cacttgtacc ctcaaagcta 38340 ttgaaataca aacttttaaa ttaaaatttt aaaaagcaag agaaaggaaa gaagggagga 38400 aagacaaaag gaagaatggg tgatagaagg aaagaataaa aggaagaaaa aatggaagaa 38460 tagatgatca gatctaggga tgaatgaaag gaaggatgga caaatctata ggtaggtgga 38520 tggatctatg gacaggtgtg gccacttatg gcacatagtc ccagctccag ttcatactga 38580 tggacttgag gagtgtttgt ggccaatgaa gtggatccat ttagacagtg ctcttcttct 38640 gaatgagatg agttacccca gtttttctcc ccaccttcat cttcaggaac tgatggcatt 38700 atggaacaca tcacaaaaat acccaatgaa gcagcacaca gaggtaccat aagaccagtc 38760 aaaggccctc agacatccac ttcgcctgcc agtcctaaag gtaggtttaa ctttgcttac 38820 ctcccagtaa tgccactcgt gaccatattt cctcctccag agagacaaaa tgtttgtatt 38880 ctttagagag agaattgtgt gtggttgtca taggtttccc tgtctgaact gagtctttat 38940 ctaatggtta ccaggcagat gttaccactg tctctttctc ctcatggcat gctgagtgag 39000 ttttgtccaa catcaaatat tcacaaattt gtccatatta accaaatttt aaaaatgctc 39060 attaaaaact tactatgagc tgggcgcagt ggctcatgcc tgtaatccca atactttggg 39120 aggctgagct gggtggatca ccagaggtca aaaattcgag accagtctga ccaaaatggt 39180 gaaactccat ctctactgaa aatataaaaa ttagccgggc atggtggcac acaccgtaat 39240 cacagctact caggaggctg aggcaagaga gtcacttgaa ccacaggagg tagaggctgc 39300 agtgagctga gcattgtgcc aatgcactcc agcctgggtg gcagagcaag actccagctc 39360 agaaataaat aatatattat atatatatat atatgtttta tttagatgga atatactata 39420 tatatatgta tatatatatg tatgtatata tatatatgta tgtatatata tatatatata 39480 tatatatata tatatagaga gagagagaga gagagagaga gagagagaca gagtatgtct 39540 gagaatgcat cccgatagtt ctagcaaggt aggaaaagga agtatcataa cagccttgaa 39600 gtagcctgtt gaaacagaca gactctcttg taagagaact cacaaaatct aggattatat 39660 ctcccatgat gaaaaatttg gaactgtaca tttttgttta actgtcactt aaatnnnnnn 39720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccaggaggc 39780 actgtgcttg gcgccttttt accaacactt tgagatggcc attgtactta tccccacttt 39840 atagacggga aaatggaggt ccagcaatat tttttaactt aaagagccac ccatctcttt 39900 agagaaagag ccagaatccc aggcaggggc tatcttattc cagagcccaa gctctcaaac 39960 acatgataca caatacttaa tctctctcaa gtcagaggag atccacttaa gtatacatcc 40020 atccacatat tcattcattc aatcattcaa caaatattag ttgagcactt accgtatgcc 40080 aaacagtcaa acgtgaatag ctgttacaaa tgagactgtg aaggatggta caacgcagat 40140 tcagacagtg tgataaggaa atattgagaa gcaaagatga gttctggagt gaatttgtaa 40200 aggtggatgt gggcttggat ttcaataatg gcagaactta aggaatctga tgagaagtgg 40260 gcacttcagg cagagagaag agcttgaaca aggctcagag gctgacagtg caggaaacac 40320 atgggaagag ggaatagagt agcggtcaag aattcacaga ggagttatag gtgaagatgc 40380 aaccaagtta cagaccaagg taagataggg gaataccaat cacaatctct tttcccattc 40440 cagaagcatc ccagacacat cctagtaacc gagagacatt tctctccctt tcctcctgtg 40500 gagaataaat aagctattgc aagtccagta agtgtaatca ttttgttcaa attgtgtgcc 40560 cattccccaa tttacaggac tacacacagg agggacaaaa agaatggaga ccacaaccac 40620 agctctgaag accaccacca cagctctgaa gaccacttcc agagccacct tgaccaccag 40680 tgtctatact cccactttgg gaacactgac tcccctcaat gcatcaatgc aaatggccag 40740 cacaatcccc acagaaatga tgatcacaac cccatatgtt ttccctgatg ttccagaaac 40800 gacatcctca ttggctacca gcctgggagc agaaaccagc acagctcttc ccaggacaac 40860 cccatctgtt ttcaatagag aatcagagac cacagcctca ctggtctctc gttctggggc 40920 agagagaagt ccggttattc aaactctaga tgtttcttct agtgagccag atacaacagc 40980 ttcatgggtt atccatcctg cagagaccat cccaactgtt tccaagacaa cccccaattt 41040 tttccacagt gaattagaca ctgtatcttc cacagccacc agtcatgggg cagacgtcag 41100 ctcagccatt ccaacaaata tctcacctag tgaactagat gcactgaccc cactggtcac 41160 tatttcgggg acagatacta gtacaacatt cccaacactg actaagtccc cacatgaaac 41220 agagacaaga accacatggc tcactcatcc tgcagagacc agctcaacta ttcccagaac 41280 aatccccaat ttttctcatc atgaatcaga tgccacacct tcaatagcca ccagtcctgg 41340 ggcagaaacc agttcagcta ttccaattat gactgtctca cctggtgcag aagatctggt 41400 gacctcacag gtcactagtt ctgggacaga cagaaatatg actattccaa ctttgactct 41460 ttctcctggt gaaccaaaga cgatagcctc attagtcacc catcctgaag cacagacaag 41520 ttcggccatt ccaacttcaa ctatctcgcc tgctgtatca cggttggtga cctcaatggt 41580 caccagtttg gcggcaaaga caagtacaac taatcgagct ctgacaaact cccctggtga 41640 accagctaca acagtttcat tggtcacgca tcctgcacag accagcccaa cagttccctg 41700 gacaacttcc atttttttcc atagtaaatc agacaccaca ccttcaatga ccaccagtca 41760 tggggcagaa tccagttcag ctgttccaac tccaactgtt tcaactgagg taccaggagt 41820 agtgacccct ttggtcacca gttctagggc agtgatcagt acaactattc caattctgac 41880 tctttctcct ggtgaaccag agaccacacc ttcaatggcc accagtcatg gggaagaagc 41940 cagttctgct attccaactc caactgtttc acctggggta ccaggagtgg tgacctctct 42000 ggtcactagt tctagggcag tgactagtac aactattcca attctgactt tttctcttgg 42060 tgaaccagag accacacctt caatggccac cagtcatggg acagaagctg gctcagctgt 42120 tccaactgtt ttacctgagg taccaggaat ggtgacctct ctggttgcta gttctagggc 42180 agtaaccagt acaactcttc caactctgac tctttctcct ggtgaaccag agaccacacc 42240 ttcaatggcc accagtcatg gggcagaagc cagctcaact gttccaactg tttcacctga 42300 ggtaccagga gtggtgacct ctctggtcac tagttctagt ggagtaaaca gtacaagtat 42360 tccaactctg attctttctc ctggtgaact agaaaccaca ccttcaatgg ccaccagtca 42420 tggggcagaa gccagctcag ctgttccaac tccaactgtt tcacctgggg tatcaggagt 42480 ggtgacccct ctggtcacta gttccagggc agtgaccagt acaactattc caattctaac 42540 tctttcttct agtgagccag agaccacacc ttcaatggcc accagtcatg gggtagaagc 42600 cagctcagct gttctaactg tttcacctga ggtaccagga atggtgacct ctctggtcac 42660 tagttctaga gcagtaacca gtacaactat tccaactctg actatttctt ctgatgaacc 42720 agagaccaca acttcattgg tcacccattc tgaggcaaag atgatttcag ccattccaac 42780 tttagctgtc tcccctactg tacaagggct ggtgacttca ctggtcacta gttctgggtc 42840 agagaccagt gcgttttcaa atctaactgt tgcctcaagt caaccagaga ccatagactc 42900 atgggtcgct catcctggga cagaagcaag ttctgttgtt ccaactttga ctgtctccac 42960 tggtgagccg tttacaaata tctcattggt cacccatcct gcagagagta gctcaactct 43020 tcccaggaca acctcaaggt tttcccacag tgaattagac actatgcctt ctacagtcac 43080 cagtcctgag gcagaatcca gctcagccat ttcaacaact atttcacctg gtataccagg 43140 tgtgctgaca tcactggtca ctagctctgg gagagacatc agtgcaactt ttccaacagt 43200 gcctgagtcc ccacatgaat cagaggcaac agcctcatgg gttactcatc ctgcagtcac 43260 cagcacaaca gttcccagga caacccctaa ttattctcat agtgaaccag acaccacacc 43320 atcaatagcc accagtcctg gggcagaagc cacttcagat tttccaacaa taactgtctc 43380 acctgatgta ccagatatgg taacctcaca ggtcactagt tctgggacag acaccagtat 43440 aactattcca actctgactc tttcttctgg tgagccagag accacaacct catttatcac 43500 ctattctgag acacacacaa gttcagccat tccaactctc cctgtctccc ctggtgcatc 43560 aaagatgctg acctcactgg tcatcagttc tgggacagac agcactacaa ctttcccaac 43620 actgacggag accccatatg aaccagagac aacagccata cagctcattc atcctgcaga 43680 gaccaacaca atggttccca ggacaactcc caagttttcc catagtaagt cagacaccac 43740 actcccagta gccatcacca gtcctgggcc agaagccagt tcagctgttt caacgacaac 43800 tatctcacct gatatgtcag atctggtgac ctcactggtc cctagttctg ggacagacac 43860 cagtacaacc ttcccaacat tgagtgagac cccatatgaa ccagagacta cagccacgtg 43920 gctcactcat cctgcagaaa ccagcacaac ggtttctggg acaattccca acttttccca 43980 taggggatca gacactgcac cctcaatggt caccagtcct ggagtagaca cgaggtcagg 44040 tgttccaact acaaccatcc cacccagtat accaggggta gtgacctcac aggtcactag 44100 ttctgcaaca gacactagta cagctattcc aactttgact ccttctcctg gtgaaccaga 44160 gaccacagcc tcatcagcta cccatcctgg gacacagact ggcttcactg ttccaattcg 44220 gactgttccc tctagtgagc cagatacaat ggcttcctgg gtcactcatc ctccacagac 44280 cagcacacct gtttccagaa caacctccag tttttcccat agtagtccag atgccacacc 44340 tgtaatggcc accagtccta ggacagaagc cagttcagct gtactgacaa caatctcacc 44400 tggtgcacca gagatggtga cttcacagat cactagttct ggggcagcaa ccagtacaac 44460 tgttccaact ttgactcatt ctcctggtat gccagagacc acagccttat tgagcaccca 44520 tcccagaaca gagacaagta aaacatttcc tgcttcaact gtgtttcctc aagtatcaga 44580 gaccacagcc tcactcacca ttagacctgg tgcagagact agcacagctc tcccaactca 44640 gacaacatcc tctctcttca ccctacttgt aactggaacc agcagagttg atctaagtcc 44700 aactgcttca cctggtgttt ctgcaaaaac agccccactt tccacccatc cagggacaga 44760 aaccagcaca atgattccaa cttcaactct ttcccttggt ttactagaga ctacaggctt 44820 actggccacc agctcttcag cagagaccag cacgagtact ctaactctga ctgtttcccc 44880 tgctgtctct gggctttcca gtgcctctat aacaactgat aagccccaaa ctgtgacctc 44940 ctggaacaca gaaacctcac catctgtaac ttcagttgga cccccagaat tttccaggac 45000 tgtcacaggc accactatga ccttgatacc atcagagatg ccaacaccac ctaaaaccag 45060 tcatggagaa ggagtgagtc caaccactat cttgagaact acaatggttg aagccactaa 45120 tttagctacc acaggttcca gtcccactgt ggccaagaca acaaccacct tcaatacact 45180 ggctggaagc ctctttactc ctctgaccac acctgggatg tccaccttgg cctctgagag 45240 tgtgacctca agaacaagta agaataactt ttttattgtg gtaaaatata aatactataa 45300 aaattgccat tctaaacatt ttaattgtac aactcagcag tactaataca ttcacattgt 45360 tgtgcaaccc tcaccactat ctgttttcaa aacttttttt atcaccccaa acaggactga 45420 aggaataatt tcccattccc cattctccct agtgcagtgg tgcaatctcg gctcaccaca 45480 acctctgaac ctctgtctcc tgggttcaag caattctcct gcatcagcct cctgagtagt 45540 tgggactaca ggtgcacgcc accgtgcctg gctaattttt gtatttttag tacagacagg 45600 gttttaccat gttggtcagg ctggtctcaa actcctgacc tcaggtggtc cacacgcctt 45660 ggcctcccaa agtgctggga ttacaagtgt gagacactgt gcccggccat atctgttaga 45720 tcttactaat cctgtcaaga ggattcagtg tccttttttt tttttctttc ttttttttga 45780 tagagtctcc ctctggcacc caggctggag tgcagtggta cggtcttggc tcactgcagc 45840 ctccacctcc cagactgaag cgattctcct gcctcagcct cccgaatagc tgggactaca 45900 ggcgcgtgcc accacgccca gctaattttt gcatttttag tagagatggg atttcactat 45960 gttggccagg ctggtctcaa actcctgatc tcaagtgatc cgcccaaggg cctcccaaag 46020 tactgggatt acaggtagga gccacctcac ctggccctat tttcggaatg gatttttttt 46080 taatgtttaa aatgtcacct aagattattg tgaagatcaa ataagataaa atcctaataa 46140 cccaagtaaa ccacagggct ccacttggac cagtctcaga agtttcaaga aaatcagtca 46200 gaccatcaaa tgtaaaataa gtctaaattt tctttgcact attcacagag tgccaaagag 46260 gatctaattc atgtttcaga acatacccta cttactaaaa tccccttttc ctcatttctt 46320 ctcattctgc aactttatca tctcctgcgg accccctagc ctctcccctc cccatagtca 46380 gtctctctct ctctctttcc ctcccctctt attatctcaa tttcacacga aagaattcca 46440 gaaactatac tgccaaaagt ctttcctgtc tttgaaaagt tgggaaagag gagaaactca 46500 gacagcaatg acaaaattat acgtaatgga tgaaggaaac acaaataagg ctggaaacag 46560 aaaattttgt ccccatcatt tatttaatga aggtggcagt attccagcca catagtgaac 46620 ccccacaata agaaggggcc tctggcgatt gattattgtc attgttgtta atgataatga 46680 gggtgaggat atcatgagca tcagtgtagg aggcagttaa ctaataagac caagctgttg 46740 gctgggcgtg ctggttcaca cctgcagtcc cagcactttg ggaggccaaa gtgggtggat 46800 cacttgaggt caggagttca agactagcct ggccaacatg gtgaaacctg gtctctacca 46860 aaaatacaaa aattagtcag gtgtggtggc gtgtgcctgt aatgacaact acttgggagg 46920 ctgaggcagg agaatcactt gaacctggga ggcggaggct gcagtgagat gagcttgaac 46980 cactgcactc cagcccgggc aacagagaga gactcttgtc tcaaaaaaca aaacaaacaa 47040 acaaaaacta aaccaaacaa aaaaagacta gctgttattc atttatttat ttatttattt 47100 agagacggag tctcgctctg tcacccaggc tggagtgcag cggcacaatc ttggctcact 47160 gcaacctctg cctcccaggt tcatgtgatt ctcccgcctc agcctcccca gctgttgtta 47220 ttcatgaatg aacctcagag aaagcacaca ggagggttgg tgcacctgtg ttttgagttc 47280 tacccctcct tcctctctta acttcctcct gtcttctcac tctgattcgt tcttccttcc 47340 tctccctctc tctctgcagg ttataaccat cggtcctgga tctccaccac cagcagtgag 47400 taaacatggc cctgaagtcc ctatgccctg ggaattcttc ctccctaagc ctgccttcca 47460 ggaggaaagt atcccccatt ccctaggttc tcatccccac agaaactcca gaatagcaaa 47520 agtctcaggc tgagccaagg cacagatgcc agtgctcacc aagagtccta ttctcccctc 47580 gctaaatgat aggacccaac aaacccgatt cacgctgcgt tttctttcag ctccgatgac 47640 ctccatgttc tctccaaggc ctctcgtatc tgtgagcccc acccccagcg ctacaggtag 47700 gaatctggct tccagctccc atgaaacgtc ggctgccatt cagtggctga ttaattgctg 47760 tgtggtctga gtcctgatgc ccaccaagtc tcagcgtgtt cccctctgtc caatctcatc 47820 caacaattta agctaatgct tgtttaatga tgtcctcact ataccacctt ggacactttc 47880 tttttgcctg gatttaaagc ttccatttct ttccttcctt ccttcttttc ttccttcctt 47940 ccttccttcc ttccttcctt ccttccttcc ttccttcctt ccttccttcc tccttccttc 48000 cttcctttct tcctttcttc ctgtcttttt ctttctttcc ttcttttggc agagtctcac 48060 tctgtcgccc aggctggagt gcaatggtgc aatctcggtt cactgcaacc tctgcctccc 48120 aggttcaagc gattctcatg ccacatgcca ctatgcctgg ctaatttttg tttttttgtt 48180 ttttgggggg ttttttgaga cagagtctca gtctgttgcc caagctggag tgcagtggca 48240 tgatctcggg tcactgcaac ctccttctcc caggttcaag cgattttcct gcctcagcct 48300 cctgagtagc tggaactaca ggcacgcacc atcacaccgg ctaatttttt gtgtttttag 48360 tagagacgac ggttttgcaa tgtgggccag gcttgtctcg aactcctgac ctcaagtgat 48420 cctccagcct cggcctctca aagtgctggg attacaagtg tgagccactg caccaggcca 48480 aaaacttgta tttcaatagt cattgaggct gggtgcagtg gctcacgcct gtaatcccag 48540 cactttggga ggctgaggcc agtggatcat gaggtcagga gatcaagacc accctggcta 48600 acacagtgaa accccatctc tactaaaaat acacacaaaa attagccggg catggtggca 48660 agatgcctgt agtcccagct actcaggagg ctgaggcagg agaatggcgt gaacctggga 48720 ggcagagctt gcagtgagcg gagatcgcac cgctgcactc cagcctgggc aacagagagc 48780 gactctgtct caaaaaaaaa aatatatata tatatatata tatattcatt gagaccgact 48840 ctgacttaaa agcagtaatg aatggtgtag gttttggtaa attacaggtc ttgctttaag 48900 tcctggtcct ctcttttgct cactgtgtgg ccccggaaga gccatgtaac ctctccaggc 48960 ttcagtgtcc atttttagaa cggagtaagt gaataagctg tgtccaatca tctctggcca 49020 tatcagcttc attttttttt tcctccaggg tccaaacatc cctccaccct cagagtcttt 49080 gcacctggtg ttcttgtcct tcaaatctca gcttggatca ccctttataa agtagcattt 49140 cccccgtata cgcatcttgc acacagccaa tctctattct acctctatgc tcacttcctt 49200 cctggcaatt attactacag ctgggccctt gaacagcatg agggttcagg gtgctgaccc 49260 ctatgcattc aaaaatccac atataacttt tttttttttg agatggagtt tcacacttgt 49320 tgcccaggct ggagtgcagt ggcgccatct tggctcactg caaactctgc ctcctgggtt 49380 caagtgattc tcctgcctca gcctcctgag tagctgggat tacaggcatg tgccaccatg 49440 cccagctaat tttgtatttt tagtagagat gaggtttctc catgttcgcc aggctgctct 49500 tgaactcctg acttcaggtg atccgcctgc cttggcctcc caaagtgctg ggattacagg 49560 catgagccat gatgcccggc catttgctaa tggcatctag taagtagagg ccagagatgt 49620 tgcaaaacat ccaacaatgc acaaagcagc ctcctatcaa aacacattat ccagaccaaa 49680 atgtcaatag ggctgaggtt gagcatctgc tgtacacaga ttccaagttc tggtacaaat 49740 ctcgtagttc tctgagggct catctttcaa tgcctagcac atcaaaggag gccaatttcc 49800 tcttcccttt cacctcctgg tatgaaatgt ttcctcctcc accttgatcc tgtaagagcc 49860 cagctggagt ttgcagacga cggggaaaga aatgggtgag ggagggtcct atggttgagt 49920 ctccgcagtg ggccctgggt gcccagttca ccctcctccc cttcattttc tccatcatga 49980 caactcaagg caaattctca gtttccatgg gccagtggaa tccactgact tcatgaaata 50040 accccaccct gagcaaatac ccctcaaata ataactgttt acacaacatc agtggcaaca 50100 atgacccaag cagcaatgcc accaccagaa tagcaaccat aacagcagct cattttcatc 50160 aaaaggaaac tgtagggcca ggcacagtgg ctcacaccta tattcccagc attttgggag 50220 gctgaggcag gcagatcacc tgaggtcagg agttcaagac cagcccagcc aacatggtga 50280 aaccccatct ctactaaaaa tacaaaaact agccaggctt ggtggcatgt gcctgtaatc 50340 ctagctactc gggaggctga ggcaggagaa ttgcttgaac ctgggaggca gaggttgcag 50400 tgagctgaga ttgtgccact gcactccagc ctgggcgaca gagcaagact ccgtctgaaa 50460 aaaaaaaaaa aaggaattgt gccaggaatt gtgatgagaa ctttatatgc attatctcct 50520 attaatatta cccaaacctc cgtgagttac tatactcatt tctacagaga gcatttatgc 50580 atccagggag gaagtaatta gcccagaatt actcagttat gacacaggac agtatgaaaa 50640 ctccaaccga agattggaga ctcatgaaaa ctccaggctc ctaactacaa gacatcactg 50700 tggatcgtcc aaatagagca agccccaatc tcaggacagg aatgaggcat gaatggcctc 50760 tatgctaatg atctaaccta atgctgaatt tgttacttcc cttctgaatc cacttggaga 50820 tttcctttat atctgacttg aaatagagga tatatactcc tctatccttg acataggaga 50880 taatacacag aaagtatttc attgtagtat caagtacaca tcctgttctg tgtccatagg 50940 attatgacta atttagggca tggcttaaca gtgtggtact attgaatgac agacagatgt 51000 ctgttttgtt ggatgcagga caagccatgt aacctcccca gactttagtg tcccctctgt 51060 ggaatggaat aaaaatacta cgtgggattg ttctgataat caaatgagat aattcaggaa 51120 caacccagat aaataacagg gctgccctgg gttctgtctt tccttgtatc tctcacagag 51180 cctcaaagga gatgcaatcc atgacctaga gaaacactca ggacaaattc tcttttcccc 51240 agttcctttc ttgctccaat ggcaacacca cccctctcat cctgaagtct cttgttttta 51300 ccaccacacc tattttgcca aattttctcc aatattccaa accatatgaa acctttcttt 51360 ctttcttttc tttccttcct ttccttcttt ctttcttttt tctcttcttt tcttttcttt 51420 ttgagacatg gtctcactct gttgcacagg ctggagtgca atggcacgat ctttgctcac 51480 tgcaacctcc gcctcccagg ttcaagagat tctcttgcct cagcctcctg agtagctggg 51540 attacaggcg cccaccgcca cgccacgcta atttttgtgt tcttagtgga gacggggttt 51600 cgccatgttg gccaggctgg tcttgaactc ctgacctcaa gtgatttgcc catctcggtc 51660 tcccaaagtg ctaggattac aggcgtgagc caccaagccc ggccccatat gaaccgtttc 51720 tatccctcat ttctctgtac ttttacctaa aaacaccact cccttcaccc atcacatttt 51780 tgtcaattct acatcacaca cacacacaca cacacacaca cacacacaga gaaagtaagt 51840 tggaaaaaaa ttatactatc atgaaatttt gtgaaaggag gtaagctgag agagtaagaa 51900 tcaaactaaa ttatctttat gggtagaaag cacactcatc catacatgtg tctttccacc 51960 cttgtaatgt atttattatt attgtttgta tatactagat tcccaataaa tagggacagc 52020 tattatggta tttttatttc aggaataata atagtgatga tttccaccat tattgtcaaa 52080 ggacaaagca caaaatatgt accaaataaa atatagccat tatcctttat tcacaaaaga 52140 tcttggcccc acctcttctc aatgaaatgt ccatgacttg ttcaactttg gccactctgg 52200 gctgagagat ggaggttccc ttgcgagctg aagtcacaca tcgaaggtgg aagcccctcc 52260 cctccctctg gctggctgag ggatagccca gatgggctca tcatgaaagt ttcccattat 52320 ttccatttct ggatctacca tcttcccctc ccctacctct cacccatcat aattgtcctt 52380 ctttactctt tcctccctat ctgcaggtta taaccgtcgg tactggaccc ctgccaccag 52440 cagtgagtat tcaaacctgt gatattccaa tgcccttggg acccttcctc cccaaggtgc 52500 attcctcaga agagaaactg atcattctcc ctccctacgt gcccagccac agcctcagag 52560 cagcccctaa cccgtcaagg tcttggtgtg agtcaagata gaagtccaaa ttccaatgag 52620 cagttcctgt cccatattcc tttaggaaga cacccaatca tttctccatg ttcttttttt 52680 ctcagctcca gtgacttcta cattctcccc agggatttcc acatcctcca tccccagctc 52740 cacaggtagg aagctcctct ctggcatcta tgaaatttaa cactgcatgg tctgttccct 52800 gctgaccacc cagactcagc ctgttccact cgccctctca ctctctctct ctctcttttt 52860 tttttttttt tttttttttt tttacggagt cttgctctgt cacccaggct ggagtggaat 52920 ggtgtgatct cggctcactg caaccttcgc ctcccaggtt cacgtgattc tcctgcctca 52980 gcctccggag tagctgggat tacaggtgca caccaccatg cctggctaat tttttgtatt 53040 tttagtagag acggggtttc accatgttgg ccaggctggt cttgaactcc tgacctcaag 53100 tgatctaccc accttggcct cccaaagtgc tgggattata ggcatgagcc accacgccag 53160 gcccactctc taaattttga ccaccctgcc ttgagtggtc ttctagcacc ctaacctctg 53220 tctaacctcg agagctttgc actagcgatt cctggggacc agctatggtt ggtatcttct 53280 caactttcta atttttttaa aattattatt attattatta ttattttaaa tggagtctcg 53340 ctctgtcacc caggctggag tgcagtggca ccatctcggc tcattgcaac ctctacctcc 53400 cgggttcatg caattttcct gcctcagcca gaaattttct cagtggtcga gattgtgcca 53460 ctgcactcca gcctgggcaa tggagctagg ctccatctca aaaaaaaaaa aaaaaagacg 53520 gaggtcgggc attcctaacc cttaaccctg ccttgtgatt ctggagttat gagatagaac 53580 ctggtgtccc gtaattaaaa ttccgccttc aggccttatg ttttgtgagt cacaacactg 53640 caaacttttt acatgctgta gacaggatgt tcactctcca cttcctcact gctctgctct 53700 aatcaattca accatttatg tgacatgcct aacccctctg ggcttgtacg tatgtaacat 53760 gtattacaaa gcaagtcatt ccatgatcaa tgctgtcact ttttctaggt gctttcaaaa 53820 tttgttcttc atcattgatt ttcagtagtt tgattacgat gtgtctgggc atggttttct 53880 ttgagtttat cctgcttaaa gtgttctcag cttcttgagt ctcaaagtgt ttattttctg 53940 ctctgattct ttctcccctt cggacctcca atgaaatgat gttgcccgaa gagaccctga 54000 ggttctgttc attttgttat ttatcaatct tttttcctct ccgaatttca ggtttaataa 54060 tttttttttt ttttttgaga cggagtctcg ctctgtcgcc caggctggag tgcagtggcg 54120 cgatctcggc tcaccgcaag ctccgccccc tgggttcacg ccattctcct gcctcagcct 54180 ccggagtagc tgggattaca ggcacccgcc accatgcccg gctaattttt tgtatttttt 54240 agtagagacg gggtttcacc gtattagcca ggatggtctc aatctcctga cctcgtgatc 54300 cgcccgcctc agcctcctaa agagctggga ttacaggcgt gagccactgc gcccggccca 54360 ggtttaataa tttttataga atattttcac aatcaccaag ccttttctct accagctcca 54420 ttctgcccat ccattgaatt ctttttatct cagttacttt atgtttcagt tcgaaagttt 54480 ctacttggtt agatagatag atgttatatc atatattata tgttatataa aaatatattt 54540 atggttatac atataacata tatgttatat atagttattt atatagccat aactatatat 54600 agccatatat atagttatat ataaccatat atatagttac catatagtaa ccacatatat 54660 aaaacatata tatatagtgt ctctctatat atagttatat atatagtttc tatatctgta 54720 actatatata gttatatatg tatgtttctc tgtatataaa tatatatatt tctatatata 54780 tagttataca cattatatat ataactggga gatgttggta aaggatggcg tgaggaaacc 54840 tggagcagtc atggtaatcc tcgctctgct ccgaactcct caagagcagg agaagggtcc 54900 tcctcattct ccagccatgt tgactttgag caatttactc atcctctcag tacctcagtt 54960 tcctcacctg ccaattgagg ataataatat ttcataaatt gtttgcaaat gttatatgca 55020 actctacgta agaacaccta gcacaggggc taccagggaa tttggtttaa caaatattta 55080 tcaggcacct attctgggct gggcaggggg gataagatgt tgactaagtc aaatgcagtc 55140 cctcccctca ccaagtttac agtgtattgg gcaagactga aatggaacaa gcaattacaa 55200 ttgacaataa aagacaacca agttattgag cacttactat atggcatgcc atatgctatg 55260 tatttttttt atttttaact tttcattttg aaataaataa taaatataaa gtaaataata 55320 atataaataa ataataaata acttttcatt ttgaaataaa taataaataa attcaggaga 55380 tgttgcgaaa atagtgtagc attcccctgt atccttcacc cagtttctcc ccaatggcta 55440 catcttacat aactctaata caatatcaaa agcaggaaac tgacattgtt aaaatccatt 55500 ttactggttt tacacgcgtg tgtgcatatg tgagcttgtg tatgtgcgtg tgtgtgcagg 55560 catgtgtgtg catgcacgcc tgtgtgtgca tatgtgcatg tgtgcatgcg tgtgtgcatg 55620 tgtgcatgtg tgtgtgcatg cgtgcgtgcg tgcgtgcatc tgtgtgcatg tatgcacatg 55680 tgtgtgtgtc tgtgcacgtg tgtgcatgca tgtgtgtgtg cgtgtgtgtt ggtagcccta 55740 tgcaattttt atcacatggg catagcccta taatcaccac caccatcaag attcagaact 55800 gttccattcc cccaaagatt cccctcatgc tagccttcgt aatcatgccc actgagccca 55860 acactattgc atagaatagc tattctactc tccatctcca tctctgtctc tacaattttc 55920 ttttgaagat gttatataaa tggaaatgta caacatgtca cctttgaaat tggcttcttt 55980 tccactcagt gtaatgccct ggagatgtgc tctttttaac agtcatgtaa ccttcctaat 56040 ttccctccaa aatatcatta tgcccctcgc cgcctttttt tttttttttt ttttttgaga 56100 cagagtctcg ctctgttgcc caggctggag tgcagtggta taatctcagc tcactgcagc 56160 ctccgtctcc cgggttcaag ggattcccct gcctcagcct cccaagtagc caggattaca 56220 agtgcatgcc accacgcctg gctaattttt gtatttttag tcgagacggg gtttcattgt 56280 gttggccagg ctggtctcga attcctgacc tcaagtgatc tgcccgcctt ggcctcccaa 56340 agtgctggga ttacaggtgt gagccaccgc gcccgaccca tattgcccat tgtattacag 56400 cggaagaaac tgaggtatgg acaggtaaca tgtccatggt cacttggctg gtgaggggca 56460 gagaggagat ttgaaaccaa atctgactca ctagtgtggc cgtaaccatg gtaactatgt 56520 ctctctacca tgtggtctcc tctttattaa aggaagggca agttctggga gttttgggag 56580 ttttgggctt gagtggggaa gggtagccaa gtaaagcagg tgagagaagg tctgctttaa 56640 ggactgctgt ttgattttta ttgttgttgt tcagtgttca atgggattga gttgactctt 56700 ttttcccttc ttgttcccca aagcatgaga ctgttccggt ccttttccct tttaacttct 56760 cagctagagt ttgttagggc gggtatgggc acctggcaga gtctgagacc tcagcttcca 56820 gtaggcacac gttctgaccc aatacaccta ccctggtccc ctaacctgct tctggtcccc 56880 taacctgctt ctgggcccag gtaatgcatt ttaggaacat cccacttttc tccttacctg 56940 gctttccatt atccgtccaa actaaagcac ccacctgtct gcttcagact cttgcttcaa 57000 gcactccgtc tgggtcctca gaaattgact tacagtcagt tcagatctga ctcaggcgtg 57060 gccttctttt ctccttcctt gc 57082 2 42348 DNA Homo sapiens misc_feature (1)..(130) Exon R1 2 agcagccaca gtcccattca tggtgccatt caccctcaac ttcaccatca ccaacctgca 60 gtacgaggag gacatgcggc accctggttc caggaagttc aacgccacag agagagaact 120 gcagggtctg gtgagagccc cgcccaccgt actcctccct cgcccactta gacaaaccag 180 cccacctcac actgcctcgc ccactgatgc cagccacgcc cacctcatcc aaccccagac 240 acctttccct gccccaccca ctgattttag ccaagcccac ctcaccccac ccagcctact 300 gatgccagcc acgcccacct ttccctgccc cgcccactga tttcagccac gcccacctca 360 ccctggtcca cccctccaat gccccactct tcctggcttc ccgcagctgt tgtttctcac 420 ctcccctctc cttccttgca gctcaaaccc ttgttcagga atagcagtct ggaatacctc 480 tattcaggct gcagactagc ctcactcagg tgagacgctc cttaagaaaa acacagccca 540 acaggtgaat atgaccctag tctctgggct ccctgactct gttcatactt ggaacaacta 600 ttgcccatgg atactaagca tcaccaccag cagcagcaga taactattcc taagacccaa 660 ggcactgcat tatgtacttt atatttaatg cctcatcagt gcttgcaaca gcctcatgaa 720 gcaggagcag aaggggaaac tgaggcccag attaagtggc ttgtgccagg acacacaaag 780 caactgcagc acttcaggtt ctatatccaa actcctatcc cttaggtggc acttcctcct 840 ctgcccccat tatgaacttg cagcatgtgg aaaaccccaa tctgacttcc ctctaaggga 900 acttgcccag agaatctaag aggggaggaa aggaaggcgt tcagccctta caggcaggag 960 gtcagctcct gagtggctca gatgcagcca cagagggcct ggccggtctg agggtgactg 1020 agaggcaccg agggcactgt ccctgagtgc tggaaagggc aggtctttta gggtagacag 1080 cggttgatat catttcctgc ctggcattct caccttccac acctctctca cagaatctcc 1140 aagtgtggct ctcccaagag agagtgtcag tcatctacct ccagcttcct ttccttccca 1200 gggggaagag gggacagggg ggccctagtg gctaagagca ttggtgaact caggcagacc 1260 tcagttctga accaacccag ctctgccatt tactatctgt gactctgagc aagtgcctga 1320 agccttctgt gccctatttc ctgacatatt atatatataa aatacatata ttatatatag 1380 acatatttta tatacatatt gaggcatatt ttataaacat gtttatagac acatttttat 1440 atgcatatgt tatatacgta tataacatat gttatatata atgtatatat tatacatatt 1500 gttatattgt atacatgtta tatatgttat agcatatata gtacaagtta tatataacac 1560 atacattatg ttacatataa tgtatatgtt atatatgata tattatatat aattatatat 1620 tatataaaac tgttatatat aattatatat aatatatagt tgttatatat aattatataa 1680 ttgttatata ttatatacaa catataacat acattatata ttgttatata taatataata 1740 tatacatata taacatatgt ataactttta tgttatacat aatgtatata acatatatgt 1800 gtatgtgtga tgtacataac atatctgaca ttaacatata acatatgata taacaatatt 1860 atatgttata acataatata tgttataata taacaatatt atatgttata acttatactg 1920 tcatatgtaa catatacata atattttata aatcagttta atatacatta tgttacatat 1980 aatgtatgtt atatatgata tattatatat aattatatta tacataattg ttatatataa 2040 tgcatacatt gtatttgtta cgtattatat gcaacatatg gggatcctct agagtcggac 2100 cagcggcagc agctgcctgc cttttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn atatacatac ataacatatg tataacttat 2280 atgttatata taagtatata acatatatgt gtatgtgatg tatataacat atctgacatt 2340 aacatataac atatgttata atatgacata ttatatatat tacatataac gtatatcatg 2400 tataatataa tgtgtatata taatatatta aagtatataa gtataaatac atgtaatatt 2460 taaatatata ttatatatag tatacatgtg gatacataca acttctacat atacctagta 2520 tatattctat atataaacag tccatgaatt acaatgattc aacttatgat ttttcaaact 2580 ttgtgataat gccatagcaa tatgcattca gtagaaagca taccttcaac acccatgcaa 2640 ccattctgtc attcactttc agtacaatat tcaataaatt atatgagata ttcaacagtt 2700 tattataaaa taggctttgt gttaggtgat tttgcccaca tgtaggctaa tgtaagggtt 2760 cagagcatgt ttaaggtagg ataggctaac ctatcatgtt ctgtaggtta ggtatagtcg 2820 atttttattt ttatttttat ttttgagaca gagtcttgct ctgtcaccca gactggaatg 2880 cactggtgcg atcatagctc actgcagcct tgaactcctg ggctcaagtg atcctcctac 2940 ctcagcctcc tgagtagctg ggactacagg tgtgtgccac cacacctggc tatttttttt 3000 ttaatttttt tttttttgtg gagaggaggg tcttgccatg ttgcccaggt ggccttgaac 3060 tcctgggctc aaggaatcct cccaccttgg cctcccaaaa tcctgggatt acaggtgtga 3120 gccatcacgc ccggctacag ggcatttttg acttatgaca ttttcagttc acaatggatt 3180 tgtcagggct gggcatgatg gctcacacct gtcatcccag cactttggga ggctgaggca 3240 ggtggatcac ttgaggccag gagtttgaga ccaggctgtc caaatggcaa aatcttgtct 3300 ctactaaaaa tacaaaaatt agccaggcgt ggtgtgacaa ctgtagttcc agctactcgg 3360 gagactgaag cgtgagaatc acttgaactt aggagatgga agttacagtg agtcaagatc 3420 acaccaccgc actccagcct ggatgacaga gcaagactct tgtctccaaa aaacaaaaaa 3480 caggctgggt gcatggctca tgcctgtaat cccagcagtt tgggaagctg aggcaggttt 3540 atcacctgag gtcagtagtt cacgatcagc ttggcaaaca tggagaaaac ccatctctac 3600 taaaaataca aaaattagct ggatgtggtg gtgggtacct gtagtcccag ctactcggga 3660 ggctgaggca ggagaatgga ttgaacctgg gaggcagagg ttgcagtgag ccaagatcac 3720 accattgaac tccagcctgg gcaacagagt gagactccat ctccaaaaac aaaagaaagc 3780 aaaaacaaaa aaataaaata aaaaacctgt gtttatcagg acataatacc atcatgagtc 3840 aagaagcatc taaatgtaca tggtagttat ataaaaatag ttatatagtt atatacaata 3900 gttatatata aaccagttta atatatgtta agtagaggta tatggtagtt atataaaaaa 3960 tagttatata atagttatag agttatataa ttatataaaa tagttatata taaaccagtt 4020 taatatatgt taggtagagg tataataata tatattgtat atactatata atatagtaat 4080 gtataaaatg caaaacgata tcatatattt ctatattaag tttatattta cagatctaca 4140 ttttatatat tttatgttat atacaattgt gttatacata atataattag tatagtactg 4200 acttggggaa ttgagcagta ccaacccata gggatgtttg aggatgaaaa tatgtgatta 4260 tgaatacaaa atgctgggcc tgctgcatag gaagtattta ataaatggta gttgttacta 4320 taaagtcgtt cctactatag agctactcac aacctgggac atagggaaag agcccgtttc 4380 cctctaatca ctcaatagtg ggtggctagg taggtgagtc cacatcctgt ggccgggaac 4440 aggtgctgag acatgaagac cttctgactg catgttggac cagccacagt ttcagacgga 4500 ccagccaaaa agggcatttt ccccaagcca tttagctccc ttgagtctca taacaaatct 4560 cctagaccct gctggtccat aggatctaga gaggatgact tgaaccttct gatcccacca 4620 tttgaaaacg ccatgccatg ggcaccagta ggagggccac tgctacgtgc accagtacaa 4680 gggccactgc catggattac agattaaccc taagtatagc tgtcgcacac ctagtacttc 4740 aggaggctta ttcggggcca tgcagatccc tggcattatt atcctaggat cctacaccaa 4800 gcaaagcagg agctgcccct cctcataaac ccataagccc tcctcttgag caaagcagct 4860 gggaaggcca gaagttattc aagctcccct ctgccccggt tccaaagaca gacagctcaa 4920 gcctacatgc agcaaaccct ataaaagtgt cacctcttgg catttctgcc atggtaatgc 4980 tttctgcttc cactaataat cctagtaatt tgtttatggt gggcatctct ctgatgagaa 5040 ccacattctt tttttttttt tttttttttt ttgagataga gtctcactct gttgcccaga 5100 ctggagtgca gtggcgcgat ctcggctcac tgtaaccttt ggctcctagg ttcaagcaat 5160 tctcctgcct cagcctccca agtagctggg actgcaggca cgtaccacca tgcccagcta 5220 atttttgtat ttttagttga gacggggttt caccatgtta gccaggatgg tctcaatctc 5280 ttgacctcat gatccacctg ccttggcctc ccaaagtgtt gggattacag gcatgagcca 5340 ccatgcctag cctgagagcc acattcttgt taaccacaat tttctcagag tctgcattag 5400 gggttgacaa agagtggaaa ggaaggacaa aaggatggag aggtggatgg actaagcata 5460 tgtaggttct tacccaggcc agagaaggat agctcagcca cggcagtgga tgccatctgc 5520 acacatcgcc ctgaccctga agacctcgga ctggacagag agcgactgta ctgggagctg 5580 agcaatctga caaatggcat ccaggagctg ggcccctaca ccctggaccg gaacagtctc 5640 tatgtcaatg gtgagcagct gtgatgtggt tggaggctct tcctccttgc tgagcagcct 5700 gtaatcactg gcttgaggtc acactcactg tcaggcaatt gaaaatttgg tcctgtgctc 5760 tacatgggat gactaatttc cggacttcat ggtatctttt tttttttttt tttttttttg 5820 agatggagtc tcgctctgtc accaggctga ggtgcagtgg catgatctca gctcactgca 5880 acctccgcct cccggattca agcaattctc ctgcctcagc ctcctgagta gctgggacta 5940 caggtgcatg ccaccacacc cagctaattt ttgtattttt agtagagaca gggtttcacc 6000 atgttggtca ggatggtctc aatctcttga ccttctactc caccttgcct tggcctccca 6060 aagtactggg attacaggct tgagccacca cacctggcca ggacttcatg gtttcttcat 6120 catcatggaa tgaattccat cagggcattc ttccctgatg tgagggcact gataggaaat 6180 ctttaatggt ccctgctgca tgaaactgct tccattgcac cagggtagcc ctgaccccta 6240 tttggtcccc cacatctcct tgtaacttac ccacactcct ccctccttct ctgtgcaggt 6300 ttcacccatc gaagctctat gcccaccacc agcagtgagt attcaactca tgtccacatg 6360 cccatgatcc tacaccaagc aaagcaggag ctgcccctcc tcataaaccc ataagtcctc 6420 ctcttgagca aagtagctgg gaaggcagaa gttattcaag ctcccctctg ccccagtttc 6480 aaagacagac tcagctcaag cccacatgca gcaaacccta taaaagtctc acctcttggc 6540 atttctgcca tggtaatgct ttctgctctc actaatgagg acttctcctc agctcctggg 6600 acctccacag tggatgtggg aacctcaggg actccatcct ccagccccag ccccacgagt 6660 aagtaccagt caatggcatc tctattagag catgctatct ctgtcatttt tactcagatg 6720 aagatggaaa atcatagcaa atctactgat agtgagtgga ccaacgaaat ttgttggcca 6780 cctagtgtgt accagatcct agagatacag gagggaaaac aaaaccaata caaaatttct 6840 gctctcagtg agcttgtatt cttgtcatga tgatgatgtt ggtggtggtg ctgttgatga 6900 cgatgatgat gatgatgatg atgatgatgc tggtgatact gttgatggtg atagtgatgt 6960 tgatgacaat gatgatgatg atgatgttga agaaaatgat gctggtgatg gtggtggggg 7020 ttattatggt aataatgata tgttgagtgt gacgatgatg gtggtggtgt tgatgatgat 7080 gatgattatt atgctagtga cattgatgat ggtaatggtg atatcaacga cagtgacaat 7140 gatggtgatg aggatgatgt cggtgatggt ggtggggtta tgatggtaat gatatgttga 7200 atgtgatgat ggtgatgatg atatttgtgg ttcatgatgg ggattgtcat ggtggtgctg 7260 gtggtacttg tgatgacaat aatgataata atgatgacaa tgatagtgat gatggtgatg 7320 gtgataataa agataacaga tatcacctta caatattgag cactaaatat gtaccaagag 7380 ctatgctcag tatctaacta ctattatata atctacttta gaaaatgaat tgtatcatag 7440 ataagaaagg cgtggaaaat atttattatg tcactcaatt taattgctgc atatggttat 7500 tacaaagtgc tattctctct actttgaaca taatgtttat ttcacactcc cactatagct 7560 gctggccctc tcctgatgcc gttcaccctc aacttcacca tcaccaacct gcagtacgag 7620 gaggacatgc gtcgcactgg ctccaggaag ttcaacacca tggagagtgt cctgcagggt 7680 ctggttagtg tcctgccctc cacactctgc cctgctcatg atacccagtc cctcttacat 7740 catccatgcc agggcaatgg aagaatatca aacccaactc acttttgccc caagagatgc 7800 aagcctcagc caggagcggt ggctcacgcc tgtaatacca gcatttggga ggccaaggcg 7860 ggtggatcac ctgaggtcag gagtttgtga ccagcctggc caacatagtg aaacctcatc 7920 cctactaaaa tacaaaaatt agccaagcat ggtggtgcat gcctgtaatc ccagctactt 7980 gggagggtga ggcaagagaa tcacttgaat caaggaggca gaggttgcag tgagtcaaga 8040 tcatgccact ttactccagc ctaggcaaaa aagcgaaact ccatctcaca aaaaaaagaa 8100 aaaaagagag agatgcaagc ctcccccacc aaggccagcc ctgcccacct cacttctgcc 8160 tggctcttac ataaaactta gccctcctac tcactgccct ctccctcctc cacagctcaa 8220 gcccttgttc aagaacacca gtgttggccc tctgtactct ggctgcagat tgaccttgct 8280 caggtgagaa cttagaattt ccagcctggc tgccccactt gtactcactc caaaagactt 8340 tgcactgctt ccttgctgca cttcctaggg atatcctcac caaaggtgga attcaggagt 8400 cacaggcttc aggatcagtg tgtttcctga cagtaacacc cctacactcc acctcaacag 8460 agagaatctg catggcccat catcaggatt gagcctctcc ctttatcatc cctctgaatt 8520 ccctccattc cctgtgcctc cctttccttt acatgttaaa ttctgtcccc aggatttctt 8580 tcaggacaat catgccttat ccacgtgatt tcatcctcat ttcgagctct tcactgggct 8640 caagtccggc tccccgtccc gtccatgaaa gtgtcagttt catcttgtca ctgtatccgt 8700 gactccactc acagtcctca gcaagccaat agtccatgca ctaagagtcg atgtggcttc 8760 tcacctcttt cccaggtttc tcatttctct ggtccttgct gtccttccct cagcaatcgc 8820 aagacccttc ctagataaac ttttcattgt gatttttccc actgaccctc cccaggcccg 8880 agaaagatgg ggcagccact ggagtggatg ccatctgcac ccaccgcctt gaccccaaaa 8940 gccctggact caacagggag cagctgtact gggagctaag caaactgacc aatgacattg 9000 aagagctggg cccctacacc ctggacagga acagtctcta tgtcaatggt gagtggctgt 9060 gatgtggttg aaatctcttc ccccttgctg ggcagcctct aatctctaac tagagatcac 9120 actccctgcc tggcctttga aaattctgtc atgtgctcta catgggatga ctaaggtctg 9180 gacttcatgg tttccttacc atcatggact gtgttccctc agggcattct ttcctgatgt 9240 gaggatgctg atagaaaatc ttcaattgtc cctgtaccat gaaactcggt tcattgcacc 9300 agggtagcat tgacctccat ttggtccccc acctctcctt gtctcttacc cactctcctc 9360 cctccttctc tatgcaggtt tcacccatca gagctctgtg tccaccacca gcagtgagta 9420 ttcaactcat atccacatgc ctcggttcct acaccaagag gagcaggagc tggcccctcc 9480 tcataaaccc attaagtcct cttcataagc aaaggattta ggagggcaga agttatttaa 9540 gtgtccctct gcccagctca agagaccgac ccagctcaag ctacacatgc aacaaacccc 9600 ataaatagtc tcccctcttg ccatttctgc caagagagtg ctttatgctt tcactgatga 9660 gaacttttcc tcagctcctg ggacctccac agtggatctc agaacctcag ggactccatc 9720 ctccctctcc agccccacaa gtaagtatca gtcaatgaca tctctatgag agcatacctg 9780 attagtgtaa acatctctgt cattttcact caaataaaga tggaaaatca tagtaaatct 9840 agtgatactg agtggacaaa tttgtttgtt tgttttttct catccttttc acttttttta 9900 ttatacttta agttttaggg tacatgtgca caatgtgcag tttagttaca catgtataca 9960 tgtgccatgc tggtgtgctg cacccatttg ctcgtcattt agcattaagt atatgtccta 10020 tgcgatccaa gcccacgcgc cgcaccacgt gcaacagttt cacagattgg atggtccgat 10080 annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10200 cttcaccatc accaacctgc agtatgagga ggacatgcat cgccctggat ctaggaagtt 10260 caacaccaca gagagggtcc tgcagggtct ggttagcacc ctgccctctt cactctcccc 10320 cgccctggat gccgagcccc tcatacaaca ttcatgccag ggcaatggaa gaatatcgca 10380 ccaaccttgc cctcatcccc agagatgcaa gcctcaccca ctgaggccag ccactctcat 10440 gggtgtctgc cccacccacc tcacttttgt ccccacacag ggaccttagc cctcctactt 10500 acctctctct ccctccccca cagcttagtc ccatattcaa gaacaccagt gttggccctc 10560 tgtactctgg ctgcagactg acctctctca ggtgagacct tagaagatcc agcctggctg 10620 ccccagttgt tcccactcca gtagattttg ctctgcttcc ttgctgcacc tcctagggat 10680 atcctcacca aaaggggaat tcaggagtca ctggcttctg gaccaatgtg tttcctgata 10740 gtaacactcc cacacctcac ctcaacaggg agaatctgca tggtccatca tcaggattga 10800 gcctctatcc tgatcatccc tcagaattcc ctgcccctcc ctttcattta ggtgttaaat 10860 tctgtcccca gaatttctct caagacaatc atgcctcatc caagtgcttt catccctgtt 10920 tctagctctt cactggtctc aagtctgggc tctcctgtcc ccatgctatg agaatgcagg 10980 tttcaccttg cacttttata agcatggttg tatctgtgac tctgtgcaca gtcccaagca 11040 agccagtagt ccatgcactc agagaatcta agtgtagctt ctcacctctt tcccaggttt 11100 ctcatttcct ctggttcttt actgtctttc catcagcagt ctcaggacac aacctaagta 11160 atcttttcat agtcattctc cccacctacc ttccccaggt ctgagaagga tggagcagcc 11220 actggagtgg atgccatctg catccatcat cttgacccca aaagccctgg actcaacaga 11280 gagcggctgt actgggagct gagccgactg accaatggca tcaaagagct gggcccctac 11340 accctggaca ggaacagtct ctatgtcaat ggtgagcagc tgtgatgtgg ttggagtctt 11400 ttccttctag agtctggaaa gaatctaatc tgtggcttga agtcacactc cctgcctggc 11460 cattgaatat tctgtcatgt ggtgtagatg ggatgacaaa gttctggact tcacagtttc 11520 ttcattgtcg tgaactgtgt tccctcaggg cactcttccc tgttgtgagg atactgatag 11580 gaattcttta atggccccag tcccatgaaa ctcattgtcc catgaaactc atttaattgc 11640 attgggattg ccatgacctt attgtgtccc tcgtatctcc ttaacgctta ccaagtctcc 11700 tccctccttc tctatgcagg tttcacccat cggacctctg tgcccaccac cagcagtgag 11760 tattcaactc atgtccacat gcccctgatc ctacattaag tggagcagga gctggcccct 11820 cctcttaaac ccataagtcc tcctcttgag caaaggagct gggaaggcag aagttattga 11880 agctcccttc cacctagctc caaagacagg cccagctcat gcccgtatgc agcagacctc 11940 ataatagtct accttcttgc catttctgcc atgagattat tttctgcttt cactgatgag 12000 cactttttct cagctcctgg gacctccaca gtggacnnnn nnnnnnnnnn nnnnnnnnnn 12060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn attttcaatt cccactacag ctgctggccc 12180 tctcctggtg ctgttcaccc tcaacttcac catcaccaac ctgaagtatg aggaggacat 12240 gcatcgccct ggctccagga agttcaacac cactgagagg gtcctgcaga ctctggttag 12300 tgcccttccc tcctcactct gcccagcccc agatatccag tcccttctac atcatccatg 12360 ccagggtgat gaaagaagat agcaacaact tccccccttc cccccaagag atgcaagccc 12420 cacccacaga gaccagtcct gcttattggt gcctgctcca cccacctcac atctgccccg 12480 acacacacac accttagccc cactactcac ctccctctcc ctcctctaca gcttggtcct 12540 atgttcaaga acaccagtgt tggccttctg tactctggct gcagactgac cttgctcagg 12600 tgagacttta gaagagccag cctgggtgcc caaacttgtt cccactctaa aagactttgc 12660 actgcttcct tgctgcactt cctaggtata tcttcaccac aaggggaatt caggagtcat 12720 tggcttgaga accagttgtt tcctgatagt aacaccccca tgccccaact caacatgcaa 12780 aatcttcatg gttcatcatc aggattgaga cactaccctg attacccatc tgaattccct 12840 cctttccctg acccctccct ttcatttagg tgttaaattc tgtccccagg atttctctca 12900 agataaccat gcctcatcca catacatgca tccgcctttc aagctcatca ctagtctgaa 12960 gctctgggtt ctcctgttcc catgccatga gaatgcaggt ttcaccttgc acttttataa 13020 aaattattat atccatgact ctgcttgcag tcccagacca agatagtggt ctatgtactc 13080 agataatcta agtgcagatt ctcacctctt tcccagattt ctcatttcct ctggttcctt 13140 gatatgtttc cctcagcaat ctcaagacaa gtcctaggca atcttttcat tgtcattccc 13200 cctcctacct tcctcaggtc cgagaaggat ggagcagcca ctggagtgga tgccatctgc 13260 acccaccgtc ttgaccccaa aagccctgga gtggacaggg agcagctata ctgggagctg 13320 agccagctga ccaatggcat caaagagctg ggcccctaca ccctggacag gaacagtctc 13380 tatgtcaatg gtgagcagct gtgatatggt aggggtctct tcctcctggc tgtgcaacca 13440 tctaatctct ggcttggggg cacactccct gcctggccat tgaaaattct gtcacgtgct 13500 ctacatggga tgactaagtt ctggacttca tggtttcttt gttatcatga gaggcattcc 13560 ctctgggcac tcttccctgt tgtgaggatg ctgataggaa atctttaatg acccctgtcc 13620 catgaaactc atttaattgc accagggtag tcctgaactc tatcgcgtcc cccacatctc 13680 cttaaccctt acccagtctc ctccctcctt ctctatgcag gtttcaccca ttggatccct 13740 gtgcccacca gcagcagtga gtattcaact catgtccatg atgcccctga tcctacatca 13800 agtggagcaa gagctggccc ctcctcttta acccataagt cctcctcttg agcaaatgag 13860 ctgggaaggc agaagttact caagctcccc tctgccccag ctccaaagac agacccagct 13920 caagcccaca tgcagcagac ctcataatag tctatcttct tgccatttct gccatgagag 13980 tgctttctgc tttcactgat gaggactttt ttcagctcct gggacctcca cagtggacct 14040 tgggtcaggg actccatcct ccctccccag ccccacaagt aagtaccagc caatggtatc 14100 tgtattagat catgcctgat gaatgcaaac atctgtgcca ttttcagtca aatgaaaatg 14160 gaaaatcata ataaatctag tgatactgag tgaaccaaaa aaaatgtatt ggccacctac 14220 agtgtaccag accctaggga tatagcaagg aaaatagaac caataaaaac atctctgccc 14280 tcagtgagct tgtgttcatg tgatgatatg atggtggtgg tggtggtaat agtaataatg 14340 acatattcag tttgatgata atttatgatt atggtgttgc tgttgatgat ggtggtggtg 14400 atgttactga caatgatggt gacggatctt tgaggatatt gtccgtgatg gtcgtgaaga 14460 ttatgatgat aatgatgatg tgttaagtgt gatgatgatg atgatctgtg gtgatgctgt 14520 ttaggatgct gttccgtggt accgatgata ttgatgttgg tcgtggttat gttgtatgac 14580 aatgacaatg atggtgatga ggataatcgc cagtgatggt gtgggtttat gatgatgatg 14640 atgtgttgaa tgtggtgatg ataatgttcg tggtggtcgt gatgggcatt actatggcag 14700 tgatggtcat aataatgatg gtgatggtga caatgatagc aaggatgatg atggcaataa 14760 agatagtaca taacatcaga caatattgag ctctgaatat gcaccacgag gagtgctcag 14820 catctaaata ctattatata atatattttt gtaaaaataa attgtattgt tttaggcaag 14880 ggaagcatgg taaatatttt gtcactcaat ttaaattctg catatgttta aagataagtc 14940 tattgcaaac tcctattttc tctactttgg acatagtgtt tgtttcccac ctccactaca 15000 gctgctggcc ctctcctggt gccattcacc ctcaacttca ccatcaccaa cctgcagtac 15060 gaggaggaca tgcatcaccc aggctccagg aagttcaaca ccacggagcg ggtcctgcag 15120 ggtctggtta gtgctccacc ctcctcactc cgccccaccc cagagagtca gtacctccta 15180 catcatccat gccaggtgat ggaacaagat catacccacc tcacccttgc cccaagagat 15240 gcaagccatg cccattgaaa ccagccccac tcactgatgc ctgttactgc cccacctgac 15300 ttctgcccta cacacccaca cacgcaactt agccctccta ctcatctcct tctccctcct 15360 ccacagcttg gtcccatgtt caagaacacc agtgtcggcc ttctgtactc tggctgcaga 15420 ctgaccttgc tcaggtgaga ccttagaaga tcaagcttgg ctgccccact tgttnnnnnn 15480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 15540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 15600 ngtgttagtc tacttttgaa cactgtttat ttcccatctt cactatagcc gccagccctc 15660 tcctggtgct attcacaatt aacttcacca tcactaacct gcggtatgag gagaacatgc 15720 atcagcctgg ctctagaaag tttaacacca cggagagagt ccttcagggt ctggtaagag 15780 ccccacatac ctcattctac cgccactcac catgtttagt cctgcccacc tcacctattg 15840 cagagcatgg aagatctcat ctacctcatc ttgcccccag atatgcatac cccaaccact 15900 gatgccagcc ccaccaactg ttgccagccc tgcccacctc ccttctacca cacccctatg 15960 acttcagtcc tcccactcac ctccctctcc ctcctccaca gctcaggcct gtgttcaaga 16020 acaccagtgt tggccctctg tactctggct gcagactgac cttgctcagg tgagaactga 16080 gaacagccag tctgactgat ctgagcagtt tgacctgctt cccttctgca ctccctggag 16140 atgtccgcag ccaggtggaa tccaggaggc agtggctcta agaccaatgt gcttcctgtt 16200 cccaccacct cccacctcaa ctgagagatg cagagcccat cagcaggact gagcttctac 16260 cttggtcatc cctctgaatt ccctcctttc ccctacctgc ctttccacaa gtggttcaat 16320 tctgttccca ggatttctcc caagaaaaac atgcctcgtc cacttgcttt catccccaaa 16380 cctagctctt cacctgtctc aagtatgagt tctccttacc ccatgctaca agaatgcagt 16440 ttccactttg caattttata aaaatccttg catccatgat tctgctcata gttgctaaga 16500 gtcagtgcac tcagagaatg gaagtatggc ttctcacttc tctaccaggc ttctcatttc 16560 ctctggcccc ctcctgtcct gccctgtggg atctcagaac ccctccctag gcaatccgtg 16620 tattgtcttt ccccaatctt gccctcccca ggcccaagaa ggatggggca gccaccaaag 16680 tggatgccat ctgcacttac cgccctgatc ccaaaagccc tggactggac agagagcagc 16740 tatactggga gctgagccag ctgacccaca gcatcactga gctgggcccc tacacactgg 16800 acagggacag tctctatgtc aatggtgagt agttgtgatg tggttggagt ctcttcctcc 16860 ttgctgggca gcctctactc tctgccttga ggtcacgctc cctgcctggc tattgaatgc 16920 tcatccatgt tgtctgtatg tgatggctga ggttggaact tcatggtttc tatttcatct 16980 tggactgagt tcatcctcag gatctgcttt ctggatctga gggtgctgat agagaatctt 17040 caatggttcg tgttctggga aattccttcc attgcaccag ggtaccctga cccctatata 17100 gttccccacc actcccttaa cccttaccca ccctcttccc tccctctcta tgcaggtttc 17160 acacagcgga gctctgtgcc caccactagc agtgagtatc cactgatttc cagtgctcct 17220 gatcctacat catgcagggc aagaactgac ccctcctcac atgcccctat gtcctctatg 17280 agcaaaggag ctgggacagc acaagttact ccctttccct tctggcccaa gtctcttcag 17340 agagagaccc agctcaagcc ccacatgcag caaggtccat aaatactcct acctgctggc 17400 atttctgcca tgagagggtt caacactttc actaatgagg ccttctcctc agttcctggg 17460 acccccacag tggacctggg aacatctggg actccagttt ctaaacctgg tccctcgggt 17520 aagtacaaat caatcgcatc tctgttagag catgcctgat gactgtcaac atctctgcca 17580 ttttcactta aataaagata aaaaatccta gtgaatctac ggatgaggag tcatccagca 17640 aacttaattg agtgcctagt ttctgcaggg ctctagggat aagaaagggg acacaaaaca 17700 gttaaaaata tctgctgcaa gaaagcttat tttattgtga gggtgatggg agttggtggt 17760 ggtgaagtta ctggagatga tgacaataag aatggtgatg ctagtgatga tgatggtgat 17820 aaggatgata attatgaaga tggtggtggt gatgatgatg atggtnnnnn nnnnnnnnnn 17880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 17940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngctgccagc 18540 cctctcctgg tgctattcac tctcaacttc accatcacca acctgcggta tgaggagaac 18600 atgcagcacc ctggctccag gaagttcaac accacggaga gggtccttca gggcctgnnn 18660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnctc aggtccctgt 18900 tcaagagcac cagtgttggc cctctgtact ctggctgcag actgactttg ctcaggnnnn 18960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnagaat tcagtcgacc taccggcttt 19020 gatgattgct cagttgaact tagaaatgca ctgtctgccc aatggtccag tctcatgagt 19080 gtgactcttt tctgcctctc ttgggtatct gatcaagatg gactcaggaa aagtgctcca 19140 gataactgtc tccaatataa cactgcccct gccatcacac ccaaatgact ggaagtttca 19200 cagggtcatc agcagggatt ggacttccac cccggccatc cctctgaatt ttccctcttt 19260 tctccccacc tcccttgccc ttaggtgtta aaattctcta actaagattt ctctcaagac 19320 aaatgtgcct cattcacttg tttaattccc aattccagct tgtcacctgt ctcaagtcta 19380 ggctgtcctg tccccatgcc atgagaatgc aagaaccaca ctgaaatgtt agaaaaattc 19440 ttttatccac aagtatgctc accgtcccaa gctggacagt agtcagtgca ctcagagaat 19500 ctaagtgtgg cttctcatct gtgtaccagg cttctcattt cctgtgggcc cttcttgtcc 19560 ttccctccgc aatcttggga ctcctcccta gacaaaactt tattattatt cccctcacct 19620 gccctctcca ggcctgaaaa ggatgggaca gccactggag tggatgccat ctgcacccac 19680 caccctgacc ccaaaagccc taggctggac agagagcagc tgtattggga gctgagccag 19740 ctgacccaca atatcactga gctgggcccc tatgccctgg acaacgacag cctctttgtc 19800 aatggtgagc aattgtgatg tggttggagt ttcttcttcc ttgctgagca ggcctctact 19860 ctctgtcttg aggtcactct ccctgcctgg ccactggtct tggccatgtt gtctgtattt 19920 gatgattgat atgaacttca ccgtttcttc ttcatcttgt actggagacc ttcatcctca 19980 ggaccttctt ccctgatctg agtgtacttg tatagaatcc tcaaagccca tgttccctga 20040 aactccttca attgcaccat ggtagcactg accccttttg gtcccccacc ttnnnnnnnn 20100 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttcactcatc ggagctctgt 20160 gtccaccacc agcactnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncctg ggacccccac 20400 agtgtatctg ggagcatcta agactccagc ctcgatattt ggcccttcan nnnnnnnnnn 20460 nnnnnnnnnn nnnnnnnnnn nnngactcca gcctcgatat ttggcccttc aggtaagtac 20520 cagtcaatgg cacctctatt agagtatgca tgatgagtgt caacatctct gtccttttca 20580 ctcaaataag attaaaaatc atagcaaatt gtacgtgatg atgagtcacc caacaaactt 20640 ctttgagtac ccactctctg ccaggcccta gagataaggc agggaacaca aaagaggtaa 20700 aaatctctgc cctcagagag cttcttttat tttgaggatg atgtgggata gtggtgatga 20760 tgatgttgct ggagatgatt acaataatga tggtgatgct tatgaccatg atgtgatgat 20820 gatggtgatt atgaagatga tgatgatgat attgatgatg gtagtggttt tgacagtaat 20880 gatgatgtga tgatgatgat gatagtggtg gtggtgatta tgggaaggat gacagtggtg 20940 gtggtgatgg tggtggttgt ggtggtgatt gacaatgtgg tggtgatatt gacaatgagg 21000 atgatgatga tagtggtggt ggttatgatg gttaaggatg atgtgatgat ggtgttggtg 21060 atcacggtac tagtggtggt gatgtggacc gtcatggttg tggttgtggt ggtgatggtg 21120 gtgatcatga tgataatgag gatgatggtg gtgattgtca tgatggtaag gatgaaacag 21180 tgatggtgtt ggtgaccatg ttcctggtgg tgatggtgca ggtgatgatg tggatgatga 21240 tggtgatggt ggtggagatg atagggatta tgaatatggt tcgggtctct gactggtggt 21300 ggtgatgaca ataatgaaaa tgatggtcac agtgttggtg atgatgatgg tggtgataac 21360 aaaggtaata gatagtgtct agtattatgg aacacagaac atcaccaaag gttatgctca 21420 gcatctaact attattattt agcatgctct atgaaaaact ttgatcgtta tagtcaaggg 21480 aggcatgaaa accttctatt ttatcactct ctttaaatct ggttgcatat gtttagaaat 21540 aaatctatta caaactctta aatgttctct acttttgaac atagtgttta tttcccacct 21600 ccactacagc tgccagccat ctcctgatac tattcaccct caacttcacc atcactaacc 21660 tgcggtatga ggagaacatg tggcctggct ccaggaagtt caacactaca gagagggtcc 21720 ttcagggcct ggtgagagcc ctgcccacct cactctgccc tgcccacctt gtcttgttcc 21780 acctacgtca cccattccaa ggcatggaag aagatctcac ccacctcccc tcacctgaga 21840 gatagccccg ccccctgatt acagcccctt ccaccttaca tcttcctcac ttctatgtcc 21900 tcagccatct tactcacctc cctcttcctc ctccacaggc taaggccctt gttcaagaac 21960 accagtgttg gccctctgta ctctggctgc aggctgacct tgctcaggtg agaactgaga 22020 ataaccagtc tggctacccc aagtgttccc aggcccaagg agtttcatca gctttcttcc 22080 ttccctccct atggaagtcc tcagcacaag tggaattcag gcgttggtgg ctccaggatg 22140 aacatatctg ctgatcctac cacctccccc atcaatcgag agaatttgca gggcccatca 22200 gccagatcag gcttctactt tggtcatcct tctgaatttc ttacttctcc ctacctccct 22260 ctccttcagg tgttaaattc tcttccaagg tttctctcaa gataaacatc ccccatccac 22320 ttgctttcat ccccaattcc agctcttaat atttctcaag tctgggctct cctgtcccca 22380 taccatgaga atgcaatttt ataaaattct tgtattcctg actctactca cattcccagg 22440 ctgcctggaa gttggtgcat tcagagaatc ttagtatggc ttctcacctg tctaccagga 22500 ttctcatttc ctctgtcccc ttcctgtcct gcccccagga atctcaggat gcctccccat 22560 aggcaatcta tttaatgtca tcccccttat ctgccctccc taggccagag aaagatgggg 22620 aagccaccgg agtggatgcc atctgcaccc accgccctga ccccacaggc cctgggctgg 22680 acagagagca gctgtatttg gagctgagcc agctgaccca cagcatcact gagctgggcc 22740 cctacacact ggacagggac agtctctatg tcaatggtga gcggctgtga tgtggttgga 22800 gattcttcct ctttgctgga cagcttctta ctctctgact tgaggtcaca ctccctgact 22860 ggccattgac gtcttggcta tgttgtctgt atgtgatgac tgatgtctga acttcatagt 22920 ttcttcatct tggactgagt tcatcctcag taccttcttc cctgatctga gggtactgat 22980 agagaatctt caaaggcccc tgttccttga aacttcttcc attccactag ggtatctgtg 23040 acccctattt gattccccac ctctccctta acccttaccc actctcctcc ctccttctct 23100 gtgcaggttt cacccatcgg agctctgtac ccaccaccag cagtgagtat tcaaccgatg 23160 ctccagtagc cccaattata caccaagcag ggcaggagct gtcctgtctt cctatgcccc 23220 tatgtcctct tcataaagga aggggctggg agggcacaag ttattccctt tcccttctgg 23280 ccagctccag agagagaccc agctcaggcc cgatatgcag caaggcctgt aaatagtttt 23340 atttgctgac ctttctgcca tgagaggctt ggatgcttcc cctgaagagg gtttctctgt 23400 agctcttggg actaccacag tggacctggg aaactctggg gatccacccc ttctactggt 23460 cccttgaata agtaccagcc aatggcacct ctgttagagc atggctgatg agtgtaaaca 23520 tctcttccat tattcagtca aataaagatg gaaattcttt ataaatctag tgatgatgag 23580 ccaaccaaca aactttattg agcattgtga caagccctgg ggctctgcca aatcctgggg 23640 atatggcatg gatcatgaaa caattaataa tctctcctct cagagagcta tttttatgat 23700 gatactgatg gtggcaatga tgatgatgtt gatggtgatt atgaccatga tgacaatggt 23760 gatggtggtg gtgatgatgg taatgatgat gatggtgatg ttggtaatga tggtggtgat 23820 tatgacaata atgatggtga tggtgacagg gatggtgatg attatgatgg tggtggtgat 23880 aacaaagtta atggataata tatgaactta ttggctactg aatatgcacc aaagtgctat 23940 gctcagtgtt taactagtac tatttaatat gatttctaaa aaaaatcttg aattattata 24000 ggcagaagaa tcatgggaac cttttatttt gtcactcact ttaagtccta ttgcatattt 24060 tttaagtcaa ttgcaaacac agtttctctg ctttgaacat tgtgtttata tccagtcacc 24120 ccaatagtgc ataaacctgc tgattggagc aactgtgtct tactcccttg tgcttcccta 24180 gtatctgctt caggaccttg tacatggtag atcgacagat ttagatctac aggaaaatat 24240 ggattttccc agggaaggaa ggaatgaagt atgctttctt ataatgtatg gaaactttcc 24300 tcttctgcct tggttcaact ttagtgtctg ccagagttta cactggaaaa ctatatggca 24360 tctgctccac tccctcatcc atgacagaca tcattaattg attgcagcat tcatggcaga 24420 catcaccaat tgataatagc attcattttc tctcagttca aaacagcttc agaatggtta 24480 ccaaaaaaaa aaaattcagt cgctaccaat tcaattggag ctgactcagg attatgggac 24540 agaattcaag agagttaggt tccttgatga tgtgtagtgg ctatttgttt tccggtccag 24600 gctaatnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 24660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ctttgtgcgg caaagttcag 24720 gggccccaaa aatttctgtg ccccaatcat ggcggaccta ggtttaggca caaattccag 24780 ggattaagtc cctggagatg ttatggcttt tggttttcct agaaaggctc agctcaggct 24840 cagcttggtc atgctgatat cctttcttcc acttggtcga tttggctgtt gatacttatg 24900 tatgcttcac gaagtttttg tgctgtgttt ttcagctcca tcggttggtt tatgttcctc 24960 tctaaactgg ttattctagt tagcaattcc tttaaccttt catcaaggtg cttagctttg 25020 cattgcatta gaacatgctc ctttagctca tcgtactttt ttattgccca tcttctgaag 25080 cctacttctg tcaattcatc catctgatcc tccatccagt tctgcaccct taatggagag 25140 atgttgcggt catttggagg aaaagaggca ctctggcctt ttgggttttc agcatttttt 25200 tgttgattat ttcccatctt caggagtttt agtttcaggc tttgaggctg ctgatccttg 25260 gatggggttt ttatgggggt cttttggttg ttgttgttga tgatgatgat gttattgtca 25320 ctttctgctt gtttttcttt caatagtcag gtccctcttc tgtagggctg ctgcagtttg 25380 ctaggggttc acttcaggcc ctattcatct gattcgctcc catgtctgga ggtgtcactc 25440 aaggaggctt ggagagcagc gaacataggt gcctgcttct tctgggacct ctgacctcga 25500 gggacaccaa cctgatgcca gtaggatcgc tcctgtgtag ggtgtctgac aactattgtt 25560 ggagggtttc gcccagttga ctggcatgga gagcaggacc catttaatga agcactttgt 25620 cccctggtgg agagggggtt cttcactggg gggaaaccac atgtctgggc tgcttggatt 25680 cctcagaact accagaggag aggctaagtc tgctggtcca cagagactac agccatccct 25740 cccactaggg gcccaagccc agggagtcca aattctgtct ctgagcctct ggctggagtc 25800 tttggagatc ctgcaaggaa gctctgccca ctgaggaagg atgggtcagg gttagccctg 25860 aagaggcact ctggctgcag actgccacag ccggtgtgtt gggctgtggg gacaagtctt 25920 gggaccaagc cgtccagcct acccggctct agcaggggaa aagtacagcc tggagctatt 25980 gaaaggggtg ccgcccttcc cccgcccagg gagcttagcg tgttaggcag ttgtgagtcc 26040 agtgctggct gtcgcccctt ccccaaggaa caaaaaagac ttagcaggca gccgcagcca 26100 gtgctggtcg cccctccccc ggggagttcc gtaggcttag gcagattcca gctgtaagaa 26160 tctgcgtgtt ctggggttgg gacactaggt cccagtggca tgggttcgcg agtgagatct 26220 tccaatctgt gagttgcaca gttccgtgga aaaagcacag tttccccctc ttgggtagcc 26280 cgctcactca ccacctccct tggctggaag gagggggttc cccttccccg tgtgtctctc 26340 aggtgggcca ccacaccaca ctgctcttcc ttctctctgt gggtcactgc cagccttcta 26400 gtcaattttg atgagggaac ctggacattt tggttgccag gaaggatcac acacttatta 26460 cagttttttt caatgtgagc ctctgagcgc tgctgcttat agtcgaccat cttggccccc 26520 agagtcacac atctgttatt ttttgatgtt ttgattgtgg caattcttgc agaagtaagg 26580 tggtatcacc ttatggtttt gatttccctg gtcattagtg atgttgaaca tttttttcat 26640 atgttcatta gccatttgta tatattcttt caacaactgt ctatttatgt ccttagccca 26700 ctttttgatg ggattgtttt tttcttgcca atttgtttga gttcgttgta gattctagat 26760 attagtcctt tgttggatat atagattgtg aagattttct cccactctgt gggttgtctg 26820 tttactctac tgactgtgaa ggaaaagtca atttcttata cgaatttgtc tcactcctac 26880 ttccaaatga gatcctgggg tttttttttt ctgttaatcc ttcacaatac ttctcccact 26940 tttttgaact catttgttta tattctgttg tctgcttctc ttttatagga atgtgacttc 27000 ttatgggctt tctctattat accacatatg ggtttttgtt ttgttttgtt ttgttttgtt 27060 ttgtttttgt cctcggatcc attctccaac ctcctccagc cttcccgtgc tctgtgggat 27120 agacgtctga ctcatgaaaa ctacatttcc caggctccca tgctaactag cttcctgtta 27180 ggttcagcca ataggaggca ttggtgggac aatggtgggc ggggctatgg aagggccaga 27240 gtatttctgt accccgcccc cctgctcccc ttccaatgtt cctggagcgg tgtaggacca 27300 atactgtata tatggaagga aggcaaggtg gatagattgg aaggaagaag tgacagatgg 27360 aaagaagaag tgataaatgg caagcgaggc aagggagcag aggatggatg agtggattgc 27420 aagaaagaaa aaaatggatg aaatataaaa ggagcaggac agatggataa gtagatggaa 27480 gtaagaaaag actggtgtaa gaaaggaacg attgatgatg gatgatgaat ggatcagtgg 27540 tgattgggtg aagggatgaa tggatggatg gacagatgga tgaacagatg ggtgggtgga 27600 tagatggatg gatggataaa atgggtaggt ggatggatgg atggatggac agatgggtgg 27660 gtaggtggat ggatggatag atggatggat aagtgaatgg atggatggat ggatggatgg 27720 ataaatggat ggatgggtga aaggaaggaa agaagtgaga gaaggaagag gaaggataga 27780 cagatgttag aaggtacaaa tgaaaggaag gaagccagca agaaagaaag gatgcattaa 27840 tagaatgaaa gatggaaggg aagaagaaag gatggaaaga gagaaggaag aatgaacaga 27900 aggaagttca agagtggtga aaagaagaaa ggcagggaga gaaggagaag taaacttttc 27960 ttctagagat ttgtcttaaa ccttagcttg gctggacact gtggttcacg cctgtaatcc 28020 cagcactttg ggaggccgag gcgggtggat catgaggtca ggagatcaag accatcctgg 28080 ctaacacggt gaaaccctgt ctctactaaa aatacaaaaa aaatttagtc aggtgtggtg 28140 gtgcatgcct gtggtcccag ctactcagga ggctgaggca ggagaatggc ataaaacctg 28200 ggaggcagag cttgcagtga gccaagatca caccactgca ctctagcctg ggcgacaaag 28260 tgagactctg tctcaaacaa aaacaaaaca aaaaaacaaa aacaaaaaac aaaaccaaac 28320 caaaacaaaa aaaaaaacct taactcatac tttcataaag ttccacacac agggagtgat 28380 tagaaagcat ttgctgatat attttatata ataaacatgt acaccatatt gacctgtgtg 28440 cccagcagtg cttacatgat ttacaatgat taacttgttt aagcttcata acaacggttg 28500 aggcaggaaa catcattgtg aaccattgtc atctcatttt acagatgagt aaactgaagt 28560 gctgagaggt tggttatggc tgcaaagatt gttggccatg ttaaccaatg catagaagat 28620 tagcatacct ggttgtgagt gcaggagaga gagagaaatg ggagaaaggc agagaaggat 28680 cgatggggag agaggaagag agagagagag aataaatttt ttaaaaatgt ctagagtcat 28740 gacttccgca tcagtgtggt aatatgcagc ctttaccctg ggaaagatca gaaccattgg 28800 tactttttac agaatcttcc cttcctgcat ttgggtagaa ggaccccatc tggacatccc 28860 aaatcattaa gcacaccctt actggctgct ggagttgtct ccattaaaag tcaccgttgg 28920 gtttattaag aggcggacac agggtcctta gaacacactg cccccacctg tcccacacca 28980 ccccccaccc acccatcatc ctccccaaga gcttcatctc tctctctctt ccccctgccc 29040 tagccggggt ggtcagcgag gagccattca cactgaactt caccatcaac aacctgcgct 29100 acatggcgga catgggccaa cccggctccc tcaagttcaa catcacagac aacgtcatgc 29160 agcacctggt gagaggcctg cctcccgctg cagccctgcc atgcccatcc tagggctgtt 29220 gcctgcctgc ctctgaccaa cccaagctcc cttctccctc tgcagctcag tcctttgttc 29280 cagaggagca gcctgggtgc acggtacaca ggctgcaggg tcatcgcact aaggtgagaa 29340 actcccccac ccacagcgca ccaccaagaa cttagagttc tgactgggag gtccctcttg 29400 ggttggggtg ggctacatat ttttttaaat ctttttatct ttcctttttt tttttttgag 29460 atgaagtttc gctctcgttg cccaggctag agtgcaatgg cacgatcttg gctcactgca 29520 acctctgcct cccgggttca agtgattatc ctgcctcagc ctccccagta gctgggatta 29580 caggcaggca ccaccatgcc tggctaattg ttttgtattt ttagtagaga tggggtgtct 29640 ccatgttgat caggctggtc ttgaactcct gacttcaggt gatccaccct cctcagcctc 29700 ccaaagtgct gggattacag gcgtgagcca ccatatctgg ccccattctt tttttttaaa 29760 tgaatttaag gagtgcaaat gcagtttttg ttacatgcat atattccata gtgaagtctg 29820 cagacagtag acttccagac agtagcttct ggtgtatcac ccgaatagtg tacattgtac 29880 ttattaagtg aggttcccca cccttctccc actctcccac ctttctgagt atccagtgtc 29940 tattattcca cactccaggt ccatgctctc acgtataagt gagaacgtat ggtattccac 30000 catgagctaa tggacatgga gtccattggc tcccacttat aagtgagagc atgcggtatt 30060 tgactatttc tgagtttcac ttaagataat ggactcccat tccatccatg ttgctgcaaa 30120 atacatgatt tcactctttt tatggctgaa tagtatttcg tggtatatat atataccaca 30180 ttttctttat ccagtcttct actgatggac acttaggttg ggtccatacc tttgctgttg 30240 aaatagtgct gcaataaaca tacacgtgca ggtgtctttc ttatataaat gatttctttt 30300 tttctttcct tttttttgat ataacgaatt tcttttattt gggttaaatc ccccaatagt 30360 gggattgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 30420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tgacctgtcc gtattgatat ataaaatgct 30480 gcatttaaag tgtacaactt gatattttgg tatacattgt taaatcatgg ccacatttca 30540 gctaattaat atatctatta tctctacata gttatcatgt ttgtaccctt tgaccagcat 30600 caccccattt gctcctcctc ccagcccctg gcaaccacca tcctactctc tgcttctatg 30660 agtctgacaa ttttagattc cacctataag ttagattatg cggtatttgt ctttctgtgc 30720 ctggcttatt tcacttagcc taatgtcctc cagctccatc tatgttatcc caagtggcag 30780 gattttcatc tttcttatat atttcattgt atatgtgtat gccacatttt ctttacccat 30840 tcatccattg aaggtcattt agcttgtttc catatcttgg ctattttgaa tagtgctgca 30900 atgaacatag gagtgcagat atctctttaa gatactggtt tcatttcttt ctttcttctc 30960 tttttttttt ttctgagaca gagtctgact ctgtcgctca agctggagta cagtggtgca 31020 atcttggctc actgcaaact ctgcctcctg agttcaagcg attctcgtgc ctcaacctcc 31080 cagggagttt tgctcttgct gcccaggctg aagtgcagtg gtgcaatctt cactcaccac 31140 aacctgtgcc tcccgggttc aagcgattct cgtgcctcag cctcccaggt agcaaggatt 31200 acaggcgccc aacaccacac caggctaaat ttttttgcat ttttagtaga gacggggttt 31260 tgccatgttg gccaggctgg tctcaaattc ctggcctcaa gtgatccacc tgcctcagcc 31320 tcctgaagtg ctgggatttt acaggcatga accaccacac atggcctcat ttcttttaga 31380 tatatatggg ttgagctatt ctcagagggt ccttttctgc atctatttaa gatcacattt 31440 tttttatatt gtggcaaaaa tacatgtaac ataaaatctg ccattttaac catttttaaa 31500 tgtacaattc agtgacattg attatattca caatgtcata cagccatcac cactatttat 31560 ttctaatact tttccattgg gtagatcccc aacagtggga ttgctgggtc aaatggtagt 31620 tctgattttt tttttttgtt ttttgagaaa tctccatact gtttttcatt tgaggttgta 31680 ctaatttaca ttcccaccaa cagtgtataa gagtttccta ggccgggcat ggtggcttat 31740 gcctgtaatc ccagcacttt gcgaggccca ggtgggtgga tcatgaggtc aggagatcga 31800 gaccaccctg gctaacatgg tgaaaccccg tctctactaa aaatgcaaaa aattagccgg 31860 gcgtggtggc gggtgcctgt agtcccagct actggagagg ctgaggcagg agaatggcat 31920 gaaccctgaa ggcggggctt gcagtgagct gagatcgcac cactgcacac ttcaacctag 31980 gcgacagagc gagactccat ctcaaaaaaa aaaaaaaaaa aaaaggtttc ctttcagtgc 32040 atccttgcca acttgagttt tctgggttgg tttgcactct catggtattt actagatact 32100 tctccattta tatttttact caacccatgc ccataacacc actcctctac cattcccacc 32160 aaccatgtat aagagttcct tttcttgcat ccttgccaac ttgacttctt tgggtcagtt 32220 tgcactctct tggtatttac tatttacttc tccatttata tttttagtca actgatgccc 32280 atggcaccgc tcctctgagg caggtgctgg gtactagagt gataagacag atgctgtccc 32340 tgccctcacc cagtggagaa gaacagatgc taaacaggaa cataaatatc taagtaaaat 32400 ggcttcaaat ggagtaaagt gatatgaaac ataaataaat agcaagtgat gggtagagca 32460 actttaccca ggatgaatct tgggctgtgt cccaaatggc catgaaaact gttccaggca 32520 gggagaacag catgagaaaa ggtcttgagg tgcaaatgag cttggcatgt tctatgaaca 32580 gcaaagaggc cagtgtggct ggagcagaga gagagcaaga agaaaagaga gaaaggatga 32640 gactcaagac atcagcaagt ttgaagggcc ttggaggact tggatttttt tttttaagac 32700 agctttgttc ttgttgccca ggcatgatct cggctcacca caacctccgc ctcctgggtt 32760 caaacgattc ctctgcctca gcctcccgag tagctggggg taacaggcat gtgcccacca 32820 cacctggcta attttgtatt tttagtagaa atggggcttc tccatggttg gtcaggctgg 32880 tctcgaactc ccgacctcag gtgatccgac cgcctcggcc tcccaaagtg ctgggattat 32940 aggtgtgagc cactgcacct ggcttggatt ttttttgttc tatattgtgg taacatacac 33000 atcacattaa attgatcatt ttagctatat ttcccgttca gtggcatcaa gcacattcac 33060 attattgtgc aaccatcacc actatcatcc atctccagaa ctttctcatc ttcccaaact 33120 gaaactccat ccccatgaaa cactcattcc tcatccccct cctcaagcct ctggcaccca 33180 ccattctact ttctgtctct gtgaatctga tgattctgag gacctcctat gaatggagga 33240 atcatatggt atatgtcctg gtttatactg tatggctggc ttatttcacc aagcataatg 33300 tcctcaaagt tcatccatgt tgtagcatgt gtcagaattc ccttcctttt ccacttgtat 33360 gtaaatgctg tattgtgttt ctccattcat taggactttg atttttgcag ggagttgtca 33420 aggggtgctg ggttctgggg cttcaatata ataagagtaa gctaaactgg ttcatttcct 33480 ccttcgtgga gaccatgttc tggtaggaac aggaacaaat aatttatgat tacatagagg 33540 gtgaccaggg cagtgacagg ggaagagtgg aggattgtgg gacccagagg aggctcctga 33600 ccttgcctag gaagatagga ggaggaagag gaggaggaag aggaggagga agaggaggag 33660 gaggaggagg agggagtcct ctaagctgag acctggagga tgaccaggaa gttatccagg 33720 taaggagaaa tggggagaag cttccagaca aaagtaacag caattgcaaa gatcctgaga 33780 tgatagataa ggtcaggtgg agaaagtgca aactgtcaat gagaccaaaa tatggactgt 33840 gagttgtgca gtgaccacaa gtggagaggt gctaggtggc cttcatcccc caaagctgca 33900 cctctccctc ctcaggtctg tgaagaacgg tgctgagaca cgggtggacc tcctctgcac 33960 ctacctgcag cccctcagcg gcccaggtct gcctatcaag caggtgttcc atgagctgag 34020 ccagcagacc catggcatca cccggctggg cccctactct ctggacaaag acagcctcta 34080 ccttaacggt gagcagctat cagccccatc tccctgcccc accccccagc ccccactgca 34140 gtccaggagg gtgtctgttt gccggttctc tagggaaaga cttggggttc aagtcttggc 34200 attaccactg gccctcccat aaccacaatg caaggttgga ctttgattaa tcccatttta 34260 cagatgaaga aactgaggct tagacaggct aagcaattta ccttgacagt ggtggaacca 34320 ggatatgaac tccacttgtc agcattcggt gctatgatcc actccacatg tttaactcac 34380 agaagagtct tcctggtggg ggcacttggg ggacaaaaaa cacatttccg gctgtgagca 34440 gtggctcaca cctgtaatcc cagcactttg ggaggccaag gcgggcggat cacaaggtca 34500 agagattgag accaccctgg acaacatagt gaaaccctgt ctctactaaa aatacaaaaa 34560 ttagctgggt gtggtggcgc acgcctgtag tcccacctac tcgggaggct gaggcaggag 34620 aatcgcttga actcgggagg cagaggttgc agtgagccaa gattgcgcca ttgcactcca 34680 gtctgggtga caagagtgaa actctgtctc aaaaaaaaaa aaaacaattt cccctccctg 34740 ctttcttctc accattgacg agggatgggc ttctctccta cctgaggccc cctataccag 34800 gaagatctat gggatctaat cttcagcgca cactgggcct cagcattggt ctagaactca 34860 ggataagata gcatttaaga aggcatcccc taaatggggt tctgagaggc aaagcatgac 34920 cgtggagaat tgacaaaata gctcgccttt catcccctcc accgccaacc caagaacagt 34980 gcttatcatc atgaccccat gaggtgggca ccccatatca cttatatgag gtacctttag 35040 gtaggtaccg ggatgtggag agacatcctg ggctttcatt actcttattt tagcaaagag 35100 ggaatctgag gcacagagaa gggaagggac ttgcccatgc ccacagcgag tttttggcta 35160 gtatgggtct tgatgttctt tctgggtccg tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 35220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tcctgcgtgg gagatgtgtg 35280 gatttgattt gtatctggaa agatgatttt ttattggtga caaagcagtt aaagttaatc 35340 ttcacagttg tgcggagagt gaccacgcga gttagtctta tccttatttt tttgatcatc 35400 ccgctacaca agacaaagcg aaccgcacag gcaacatcag caggccccat tggtgtgttc 35460 ccctctatgg gtccatgtgt tctcatcatt agctcccacg tataaagtga gaagatggca 35520 gtattggttt tctgttcctg cattagtttg gtaaggataa tgacctccag ctccaaccat 35580 gttcctgcaa cggacatgat ctcattcttt tttatagctg catagtattc catggtgtat 35640 atgttcctca tgttctttat ccagtctatc cttgatgggc atttaagtag attccatgtc 35700 tttgctattg tgaatagtgc ttcagtgaac aggtgtcttt atgatagaaa aatttatatg 35760 cctttgggca tatatgcagt gatgagattg ctgggtcaga cggtagttct gtttttagct 35820 ctttgaggaa tcatcctgct gctttctaca gtggatgaac taatttacac tcccaccaac 35880 agtgtataaa cactcctttt tatctgcaac ctcagcagca tggttttatt tctctttatg 35940 gctgaatagt gttccattgt gcatatatac cacactttct ttatggattc atctgctgat 36000 ggacatatag gttgattcca catctctgct attgtgaata gtgctgtgat aaacacacag 36060 gtgcgggttg ggtcttgatg atctcagtta acatccagtc ccttcaactt ggctattgca 36120 gggagctgtt cccccttgta aactgcacag cttatgtgct tcattttgtt ccttcattta 36180 gatttaccaa gcagctacta ttaaccaggc cacaatgtgc ctcgccccca ggaacagaga 36240 taggttacat gtgcatcctg tcctaatgta atctccaggg gggcggagac tgttttgttc 36300 taccctatat tccccaaatg taaagggagc cttgcacata ctaagccctt aataaacatt 36360 cattgggtgg aggaatagat tggaggaggc ctggaagggg aggcgggggt tatggatgga 36420 taggaggata gacttgtgaa cacaaaggta gtgagagcct ctcattggag gcatgctgga 36480 gacgtgagta gggaagggtc agtgctaatt gaaatatcag gaaattcttt ctagtggtga 36540 acacatttaa gtcaaatatt agatgataca taaatgtatc cataatctct agatacacaa 36600 agggaaaggc atccaggcag gggccccata tggacaaagg catggagtat ctgggacggt 36660 tccaccacct cctcttacgt gtgacttctt tgtttcaagg ttacaatgaa cctggtctag 36720 atgagcctcc tacaagtacg tgtctttgaa tctagtgccc atttcaatct ccatgggtct 36780 tggttcaagc ttttctcctc attcatgaag gaaggttgcc ccaaattcgg gctggtcccc 36840 taggtggtga ggggcattgt ctcagtggga ggaagaatgc tgagtccttg gccctgtttt 36900 tagacctgca gccatagtct tggctttgtg aattttccat gtccctctgg gttggaggaa 36960 gaagtttgaa caagcattcc ctacacggga tagaggttga ggtcagatga tgacctctgt 37020 tagtctgtac cctccttgat aagaaaatct cctccaagtg ccccagcaga ggcttcatgg 37080 tcaagctgca gactctgctg gctactggtt ttggctaaat ttgcccattg cctcatccag 37140 tgatccactc gtctatcttt ccagccatcc atttttctat ccttccagtc atctctcaga 37200 caccacctgt ccttccatcc atccatccgt ccatccattt acccatccat ccatccaccc 37260 cattttcctg accatttacc tcctcgtcct tccttccatc tgtcctttta tccatctatt 37320 catccatcac ccatcctcct gcccattcac ctgcttgtcc ctcctttctt ctgtccttct 37380 atacatccat ccatccatcc atccatccat ccacccatcc actcatccac cacccaccca 37440 tccttctgcc cactcactcg ctagcccctc cttccttctg tccttccatc catccatcca 37500 cccatcttcc tgcccattca cctgcttgtc cttccttcta tctgtctttt atccatctct 37560 ccatccattc tcaccatcca tccatccatc cttctcccta ttcactggtt tgtctttcct 37620 tctgtccttc caaccatcca cccatctctc cattcattct cctcttcatt caccatgttt 37680 ccttatttct gtctcttcca tccatccatc tatccagaca gacatctcct ccccccattc 37740 tcctccccat tcactcaatt gtccttcctt ccatctgtcc ttttatccat ccatccaccc 37800 atccatccat ccatctatcc ttctccccat tcacctgttt gtccttcttt ctgtccttcc 37860 aaccatccat ccatccatca tccatccatc tatccttttc cccattcacc tgttttgtcc 37920 ttccttctgt ccttccaaca tccctccatc tctccatcca tcctcctgcc tattcatctg 37980 cttgtctttc cttccttctg tccttccatc cattcatcca tctgcccatc cacccactca 38040 tcctcttgcc cattcacctg cttgtccttc cttccacctg tccttttatc catccatcca 38100 tccatccatc ttgctcactc ctccactcac acaatcactc cttccctcag tctcatttat 38160 ggcccacctg tgaatggttg tcctggcttg gaccactgat gaagcccagg ggagcttctc 38220 ccactagtgg tgggcttttg tcctctctga tggactgttc cttccacagc tcccaagcca 38280 gccaccacat tcctgcctcc tctgtcagaa gccacaacag gtatttgggg ccatttttcc 38340 tcctcgaaga ttagaatagc atttcaatca gacacctgcc ctcgtggagt cccagatttt 38400 atgaaataaa tagaccatca taatgtcaga tgttttgggg tgagatacct ggcatagttg 38460 ggaaggagga gggctttctg gagaaagttt cacctgaact gagtctttaa ggatgactaa 38520 gagtgattca ggcaaatagg gcatgaatag tataactgaa agaggggaat ctgtgagcaa 38580 agcctcagtg gccagaaaca gcatagagta tagggagaag tgagagaaat ttggtttgca 38640 tgaaacataa agcttaaccc agagtggatg gataagtgag actgaaaggt cagcaggagc 38700 cagattggga agggccttga atgccaagtc aagaaatttg aacttaacac tgaaggccat 38760 agggagctgt ggatggtact agagcagggg cagccatagt gagattgtca tttcagaaag 38820 attcttcttg tgttcagtat agagaatgtc ctttagacag ggcatccagt gagtctgcca 38880 ggtgctaatc agggtgagag aaaataagac ctgaactggg atagggggag gagagagagg 38940 atatatgtga tgaatattca gtaaagagaa ttggtgttac ttggagggga gaagacacat 39000 agcttctgac ttgcgatggc cacactcagt ttaataatga gcgcagtctg atctagtctc 39060 agaccagccc tcagttgcag acgtctctcc tcccctcctg cagcatgggg taccacctga 39120 agaccctcac actcaacttc accatctcca atctccagta ttcaccagat atgggcaagg 39180 gctcagctac attcaactcc accgaggggg tccttcagca cctggtgaga ccctggtccc 39240 agcagctcct ggtgggataa atcctacccc caacctctgt tcctcggctt accctcttcc 39300 tccttcctct caagctcaga cccttgttcc agaagagcag catgggcccc ttctacttgg 39360 gttgccaact gatctccctc aggtgagacc acttcctggc catttgccag taacaaccac 39420 cccttttgtg accacccctt cctcagcttt cccctgctcc tccctccact gctctttacc 39480 tgcagaggtc tcgggacctc tctagagtcc tcaaatgcct ctctccccag gcctgagaag 39540 gatggggcag ccactggtgt ggacaccacc tgcacctacc accctgaccc tgtgggcccc 39600 gggctggaca tacagcagct ttactgggag ctgagtcagc tgacccatgg tgtcacccaa 39660 ctgggcttct atgtcctgga cagggatagc ctcttcatca atggtgagtg tcaggctgaa 39720 cttggattta cagtgacttt tggggagttg gtttctttgt ttttgagatg gagtctcact 39780 ctatcaccca ggctggagtg caatggtgca atcttggctc tgcaacagtg attctcctgc 39840 ctcagcctcc caagtagctg ggatttacag gtgcatgcca ccacgctcag ctaatttttg 39900 tatttttagt agagatgggg tttcaccatg ttgcccaggc tggtctcgaa ctcctgacct 39960 caggtgatcc acctgccttg gcctcccaaa gtgccaggat tacaggcatg agccaccatg 40020 cccggcccac catgactatt atttgtccct gttgtatgcc ctttcctctc taaaaaaaat 40080 agcccaaggc ctggctgggg gacacccttc cccaaaccac caaggggagg gtctttccca 40140 ttattttgag taaatagcat gaaattcttt gaccaaatta atgtcataaa ttgtttgtct 40200 ctttctcctt cacttttgtt tccaacttgg ttgcggtata actatcaaat acaattgtat 40260 gtatttaaga tgtataatgc agtgatttaa tatatgtgta gcttatgaaa tgattaccat 40320 gatcaaatta gttaacactg ctttcatgtc acatagttac cgtgtgtctg tgtgcgtctg 40380 tgtgagttag agagaaagag aacatttaag gtctaccctc atagaaaatt tcaggtttac 40440 aatacagtat tattaactat aatcatcaag ctttatactc gatccccaga acttattcat 40500 cttgtaacta aaagtttgta ttttgtgacc aacatctccc cattttctct atcaccaccc 40560 ccatgccccc agcccctgat aaccatcatg ctactctctg cttctgtaag tttgacttct 40620 gatcccacat ataagtgaga tcatgcagta tttgtttctc tctatctggt atatttcact 40680 tagcataatg aacccccccc aggtacatcc ataatgaatt tcaattcaaa acccaagtgg 40740 ctgagtcgtg gcatcctttg ggacaggata gcaggtccct tctatataag gatcctctgt 40800 gtcagtggtt attaccaggg gacaattctg cacttctgcc ccaccccacc ccccaactgg 40860 gagactctag gcaatatccg aaatcatttt tgggtatcac aactcaggga gggaaggagg 40920 gtgcaactgg cacctagtgg gtcggtagcc cattttccag tgcacaggag acaaccaccc 40980 cagggaatga tccagcccca aatgccaata atttcaaggg tgagaaatcc tgttgtacat 41040 ggtctcaaag ttcttaggtg ggcacaaggc tgacatttat cacactttac tgtaattact 41100 tgttaaattt atctgattcc cccttaccct gtgaactcaa caaaattacg gtctattatg 41160 agtgccactg taccctcggt tcgcagtaca tcagcacatc atagtatgga aagaatcatt 41220 gaatgagtga gcaaattaaa gatttgtgtc tctgctgtaa ctcacattca ttaattcatt 41280 cattcagcaa acatatatgg gtggctgttc tgccccaagc cttgtactgg gtctggagat 41340 agaagacaca tttttctgtc tctgaaaaac tcatactcaa gttaacaaca aattacgggc 41400 acaacaaaga ccccactgct gttattaaca gggtactatg ggagctgaga ggaggagtaa 41460 attaaggagg gcttcctgga ggagggtgtt atatacccgg ccctgtgccg ggacacataa 41520 tgataagaca gacttgggcc tctgctgtcc tggagctccc tctcactggg ctcttgaagc 41580 gtgagcagga gttttgcagg aaatgaaaag gatgcattcc tagaagtggg aactgcatag 41640 cacatgcagg aaagctcagc tcagaagaat ctgtgtaata ttccattttt ccctctcttt 41700 ggggcaactt tctgtctaag agctcctgca atgcccagcg tgtggacctg aaattgattc 41760 tgacagtagg caggggactg ctgggcaact ttggctctgc attttgtgat caacatttcc 41820 ccaccatatg ttgccttttc ttcttctctg tggctccagg ctatgcaccc cagaatttat 41880 caatccgggg cgagtaccag ataaatttcc acattgtcaa ctggaacctc agtaatccag 41940 accccacatc ctcagagtac atcaccctgc tgagggacat ccaggacaag gtggggcatc 42000 tctcacccct cccgtcttct ctgtcctgtg tgcttctctc cctcttctac ctgatttctc 42060 tgttaagtga tcactttaaa tgcttcactt cactatgtat tctgggttct ctctcagttt 42120 ccaaaagtac tctcttgact accattccca tttcacagat gggcaaactg aggctcagaa 42180 aggggcgtgg tgtgcctagg gtcatacagt gctttaggaa cagagttagg atttgaactc 42240 tggtcccctt tgctccaagt cctgtgtttt tttccactgg catcagcggc ccctccaccc 42300 ccaagaggcc tccatctcac ccactctccc tacccatctt tctaggtc 42348 3 14277 DNA Homo sapiens misc_feature (1)..(66) Exon C1 3 accacactct acaaaggcag tcaactacat gacacattcc gcttctgcct ggtcaccaac 60 ttgacgtaag ttctgaaggt cataagcagt gaccaagctt gtggctgtgt ctctgagcac 120 ccttgagcta gacgtcccca gtggggtacc cattctcccc tacatccctg tctagctaat 180 cctaccatct cctcccataa atcctcaagg tagggagtga ggattaacct catggggcca 240 ccaactccca gcatacacct tctttttttt ctggacactt gggaaaatat aactttttga 300 tgtagaactc aaaatattag cccaataata atatttaaca tcaaccagcc tcctctcatt 360 taattctcac aacagaatct atgagttgag tgcaaaaatc atccctattg tgcagatggg 420 aaaactgagg gtcagaaaag tgaacttccc aagaactgtc aaagttggga tttgaaccca 480 ggtctctgat gactggatga aggaatgaag atacctatac ttgggaatga ggagggtcga 540 caggacacga gggctgactt tgtatatttc taaacttcaa agattttctg tatttcagct 600 gggaatatgg tagaaggtta attggaacaa aaaaatgcaa agcaatgaat aagacctcag 660 tatttgctat gcacaacagg gtgactgtag tcccacaaat aacttcactg tacattgtta 720 aaatataact aaaggtgtat gcttggattg tttgcaacac aaaggatata tgcttgaggg 780 gatggatacc ccatttaccc tgatgattat tatgcattac atgcttgtat caaaacatct 840 catatacccc ataaatataa aaacacctac tatgtacccc aaaaaattaa aaacaaataa 900 aatcaaaagt aggctgggca cagtggctca tgcctgtaat cccagcactt tgggaggcca 960 gggcaggtgg atctcttgag cccagaagtt caagaccagc gagggcaaca tagggagtcc 1020 tagtctctac aaaaaataca aaaattagcc aggcatggtg gcacacacct gtagtcccag 1080 ccactcagga agctgaggtg ggaggatcgc ctgagcctag gaggctgtac tccagcctgg 1140 gtgacagagc gagactctat ctcaaaaaat aaaataaaat aataaaaagt agaaatcaag 1200 agggaaaatg tgggagaaat tgggataatt ttaacaatac cttccaccag agtgatgatg 1260 aagaatgcat aagtcacttc ttagtggtct tgatctataa aaagtgttca ataaatatcg 1320 attattgtta ctgttattgc ttctagacgt aattcctgga agcatttttt tttttttttt 1380 ttttgagatg gagtcatgct ctgttgctca ggctggagtg cagtggtatg atctcggctc 1440 actacaactg cctcctgggt tcaagcaatt ctcctgcctc agccccccat gtagcaggga 1500 ctacaggcat gcgccaccac acccggtgaa gttttgtatt tttattagag acagggtttt 1560 gccatgttgg tcaggctggt ctcgaactcc tgacctcagg caatttgcct gcctcggcct 1620 cccaaagtgc tgagattaca ggcttgggcc actgcatcca gccgaaggcc tcccattttg 1680 atcagaaccc ttctctagac tgagggtggg tgcctctaga tcttttgctc tttaaagaca 1740 gcaaccgatg accctgctga tgctgagtac tggctgaatt cctgtggtct ctgtccctag 1800 gatggactcc gtgttggtca ctgtcaaggc attgttctcc tccaatttgg accccagcct 1860 ggtggagcaa gtctttctag ataagaccct gaatgcctca ttccattggc tgggctccac 1920 ctaccagttg gtggacatcc atgtgacagg tacaaggtgg ggtggctggt ttcctaactg 1980 gaagaggtgg ggttatgagg aaagatgggg cttctcggta ccagtggaat tggtggaggc 2040 tctagagagg gaaagggagg ctttctggag acccatgtag gtgacctctg gcagtagatc 2100 atccaacgag gcaggaacag aacaccagcc attgcatcta agagaatagc tatttttaca 2160 tgtaaaaaga attgtgttga atgaatgaat caatagatca tttattttga atcaatttat 2220 tgattcattc atttaattaa tgaataataa atgattcagt acataattga ttaattgatg 2280 taattgagaa ttgatttaat tgattaattg atcaattaaa atgatcaatt aaatgaatga 2340 atcagtaaat gaataattca ttcattcaat aaacaatgga agtaggccgg gcatggtggc 2400 tcacgcctgt aataccagta ctttgggagg cccaggcagg cagatcacga ggtcaggaga 2460 ttgagaccat cctggctaac acggtgaaac cctgtctcta ctaaaaatac aaaaaaaatt 2520 agccaggcat ggtggtggcc acctgtagtc gcagctactc gggaggctga ggcaggagaa 2580 tggcgtgaac ccgggaggca gagcttgcag tgagccgaga tcgcgccact gcactccagc 2640 ctgggcgaca gatggagact ctgtctcaaa aataaataaa taaataaaaa taaaaaataa 2700 ataaacaatg gaagtaaaca cgtactgata acacagtgtg atcattgcta tgataaggga 2760 atttcagggg cctgtgggag ccccaaggag gaacacacaa ccttgtcttg gaaagtttta 2820 tgtaggaagg ggtgaagaag ctgagatctg acagagaatg ggacctagcc aggggtaata 2880 gatggagaat tgtgctccat gcatctataa cctagaagat agaaagaata tggcatctgg 2940 ccgggtgcgg tggctcacgc ctgtagtccc agcactttca gaggctgaga tgggtggatc 3000 acctgaggtc aggagttcaa gaccagcctg accaatatga tgaaacccca tctctgctaa 3060 aaatacaaaa attagccagg catggtggtg cgtgcctgta atcccagcca cttgggaggc 3120 tgagagagga gaactgcttg aactcgggag gcggaggttg cagtgagccg agattgtgcc 3180 attgcactca agcctgggca aaaagagcaa aactgcattt caaaaaaaaa aaaagtggca 3240 ttttggggca agtttaagaa gattggtgta gctggagcat ccactttgat actggagagg 3300 tgacagttga agccaaagat gtgggcagag actttgttgg gcactggaat ggcttgggga 3360 ggaacatgac acactcatga gttctgcttt agaaagaaaa tgaaatgaat tctgctcatc 3420 ctctgggtgc tgtgtgcaga atggagggtg gggggagaga agagcaaagg caagaagacc 3480 ctttaggaac aatgatcatt agttagaaga ctctgggttt ctcagcacct gcaattgctg 3540 actacacccc cagagaaacc cagtctcttt tcccccatgt tgtagagaat tcttacaatg 3600 cttggtagaa agagaattga acaggtagat gggtggatgg atacaagctg gacagatgga 3660 tggaggaaga tcctccatcc aatatagagc tgttacctaa aaccctccat cccaccttta 3720 aaatcctagc tcagccaggc gcggtggctc acacctgtaa tcccagcact ttgggaggcc 3780 aaggcgggtg gatcacttga ggtcgggggt tcgagaccag tctgaccaac atggtgaaac 3840 ccccttctcc actaaaaata caaaaaaaaa aaaaagttag ccaggcaggg tggcgcatgc 3900 ctgtaatccc gctactcggg aggctgaggc aggagaatgg cttgcaccca ggaggtggag 3960 gttgtggtga gccaagatca cgccattaca ctccagcctg ggcaaagaga gtgaaactgt 4020 ctcaaaaaac aaaacaaatg acccccctgc caaaaaaaaa aaaaaaaaaa aagaaaagaa 4080 aaaaagaaaa gcctagctca gctcacactg tcaggaataa gtaagctagc tggaatcatc 4140 tctttcttaa aaccctgcct tgatagtgga tttttacata cttttttttt aattctagaa 4200 atggagtcat cagtttatca accaacaagc agctccagca cccagcactt ctacctgaat 4260 ttcaccatca ccaacctacc atattcccag gacaaagccc agccaggcac caccaattac 4320 cagaggaaca aaaggaatat tgaggatgcg gtgagaaggg ggtggtatgt ccactctgtt 4380 gccatgcaga aactgactta tgcatactgg gtagccacag ggtgactttt tataacaatc 4440 cacaaagaca ggttcttatt cccatttaat acacaagcac agagaggttc agtagctgac 4500 ccaaggtcac acagctaagt cataccctag aagagcatgt cctttgatat acatacctgg 4560 gcaagtggtt gtcatgacaa gaagcaaaat agacggagaa gtgtgctcag tggctgaaaa 4620 ttctctgatg ctactggggc caggattctg acctaagaaa catcgccctg tctttcagct 4680 caaccaactc ttccgaaaca gcagcatcaa gagttatttt tctgactgtc aagtttcaac 4740 attcaggtaa gttctaactc aggacctaat gactctagga acttctgctg tcctttaaat 4800 agaagtgtcc ccaagccata gctttgatgg aagagagccc tagaaataga gagctgttaa 4860 ctaaaaacta gctttttcct aaagctggag cccaactggc ttcaacactc aagagagctg 4920 gtgtaaatct cagcagacat aaaggtacct ggtgctgagg ccatggagtc tagagtgtag 4980 aatctactac attaagacat cagctactga aatcaggacc catggaagac gggggaagga 5040 ggggactaaa accagattac ttagaatcta gcagcctaac tgtgcttttc aatgagaggt 5100 atcatttcca atggtggggg gtaccaatga tttttttttt ttgacaactg ccttgagaac 5160 aggctttcct cactaaacaa attctgaatc agaacaaata aagataagcc ctgagaatag 5220 ggctttttca aggagctgcc aaacagatca aatagtgact atgttctgca gattgatgtc 5280 tggagaactc tacagctatt ttgactgcta ggcagctggt tttcacagat atcatgattc 5340 tgaggctgcc agttttcaaa gttaccgagg atcttgctgg atgcagtggc ttgcgactgt 5400 aatcccagcc ctttgggagg ccaaggtggg tagatcgctt gagctcagga gtttgagacc 5460 agcctgggca atatggtgaa aacccatctc tacaaaaaat acaaaaatca gctgagcata 5520 gtggcatgtg ctgtagtccc agttacttag gaggctgagg tgggaggatg gcttgagccc 5580 aggaggcaga ggttgcagtg agctgacatt gtgccatgca ctctagcctg ggcaacagag 5640 ccaaagcctg tctcaaaaaa aaaaaaacaa ataataataa taataaaata ctgaggatct 5700 tgaaagagca ctgtggaaat aatgcaagtt aaaatgccac aaagcttgct ctttttactg 5760 agatttaaca ctttccttaa ctaaacaccc ctcgaatttt tgcaagcctt tggttcactt 5820 ctagacttct ggaaaaattg atttggacta ttttggccaa tgttctcatt gattttatgg 5880 gtattcagaa gttgttaccc caacattcca gaaatgttct ccctgtggct attactttat 5940 ttatttattt atttatttat ttatttattt atttgagacg gagtctccct ctgttgccca 6000 ggctggagtg cagtggcgca atctcagctc actgcaacct ccgcttccca ggttcaagcg 6060 attctcctgc ctcagcctcc caagtagctg ggattatgga tgtgcaccac cacaccggct 6120 aatttttgtg tttttagtag agatggggtt tcactgtgtt ggccaggctg gtctcgaact 6180 cctgatctca agtgatccac ccgccttggc ctcccaaagt gctgggataa caggcatgag 6240 ccactgtgcc tgacctccct gtggctattt ttaaatgaat taagtggaat aaaattagaa 6300 attcagttct tctcccacgc tagctgcatt ttaagcattt aataacaaca tgaagctact 6360 aatggctgca ttgtgtagtg cagatgtaga attttttttt tgttttttgt tttgtttttg 6420 agatggagtc tcgctctgtc accaggctag agtgcagtgg cgtgatctcg tctcactgca 6480 atctctactc cccgattcaa gtgattctcc tgcctcagcc tcccaagtag ctgggattac 6540 aggcacgtgc caccacaccc agctaatatt tgtatggatg gtctcaatct cctgacctcg 6600 tgatttgtat ggatggtctc gatctgacct catgatccgc ctgcctgggc ctcccaaagt 6660 gctgggatta caggcgtgag ccactgtgcc cggccgacat agaatgttta catcattgca 6720 gaaagtttct gcaggaagag cctagaagga gaaagcctag aatcatgata aaattgcaga 6780 tatctttgct tatccctgtc cccttccagg tctgtcccca acaggcacca caccggggtg 6840 gactccctgt gtaacttctc gccactggct cggagagtag acagagttgc catctatgag 6900 gaatttctgc ggatgacccg gaatggtacc cagctgcaga acttcaccct ggacaggagc 6960 agtgtccttg tggatggtaa agctccctgg gtcattggga ctgaggtgga agctcccact 7020 tcctcacctg ggtccttccc tgggaatctg aaggcttggg gttgattcgt catcgagctt 7080 tctcagactg ggagaaagtg gcttagttct cctaagcttt acccatcatt gaaggaaaga 7140 aaaggacgcc cgagggatat gggaggcatt tgccctcttc tggccagctc tgtgacctca 7200 ggctagtcac atctcctttc tggacttctt atctctctgt acttagcaag ccacttggtt 7260 tttggttccc atcttgcctg ccctagatgg tattgctcct ccacccccag gcagctgcag 7320 tgttaaacaa ttaccctgat tagttattgt tgttgtgttg tttgtttgtt tttgagacag 7380 ggtctcactc tgtcacctag gctggagtgc agtgacatga tctcagctca ctgcaacctc 7440 aacccctgga ctcaagcaat ccacccactt cagcctccca agtaactggg actacagcca 7500 tgcgccacca cacccggata atttttgtat tttttctaga gatggggttt tgcaacattg 7560 cccaggctgg tcttgaactc ctgagctcaa gcatgccacc tgcttcagcc tcccaaagtg 7620 ctgggattac aggcaggcag gcaccactgc agctggttct ggttttttgt gtttgttttt 7680 ttcttttaga ggcagggtct cgctctgtta accagaatgg agtacagtgg tgcaatcata 7740 gctcactgca gtcttgaact cctgggctca agcgatcctc ccacctcagc ctcctgagta 7800 cctggaacta caggcacgtg tcaccacgcc ttgctaattt ctaaattttt tgtagagaca 7860 gggtctcact atgttgccca gactggtctc taattcctgg ccacaagtga tcctcctgcc 7920 tcagcaggtc aatgagggct tccagtttca agttgtatgt gattcatcct caacaaatgt 7980 ggtaggatgg acctattttc caactccaga gatggcttca aggtggctca actttgcata 8040 tccaatttta cccattcaaa gaatagttat atacattgta ccatgtatca ggaatataac 8100 agagagtaac tgtttgctct ttcaccacta tattccaaga accccatatt ctgcctggca 8160 cataataaac actcaagtca tatttgcaga aggaataact agatttcata caaggttctt 8220 ttcaagtcaa atgcgaataa cgttttagac gggaccttcc aatgcctgtg tgcactgtcc 8280 ttgattccga attattgttg tgcaagagag cactgttgat ccttcagaat caacaagcct 8340 ttcacatgcc tgtcacaggt ttttcttttt cttgttttac caattttgtt tgttgtttgt 8400 ttgttgttat tgttttgttt tgtttttgtt ttttatttgt ttttattttt tctttttttt 8460 tgagacagag tctcgctctg tcacccaggc tggagtgcag tggcacgatc tccgcccact 8520 gcaagctccg cctcctgggt tcatgccatt ttcctgcctc agcctcctga gtagctggga 8580 ctacaggcgc ctgccaccat gtctggctaa ttttttttgt atttttagta gaaacagggt 8640 ttcaccatgt tgaccaggat ggtctcgatc tcctgacctc gtgatctgcc cacctgggcc 8700 tcccaaagtg ctgggattac aggcgtgagc caccacaccc agccccaatt ttttttttaa 8760 ttaaaattgt tgtcagctca caagctttct aaaaacaggc catggaccca gcatcgctgt 8820 agtttgccaa acccttgcct tgaatcagta ccatccaata gaactttctg cagtgataga 8880 aaatgtttct atctgtgcta ttcagcacaa agccatgtgt gattactaag cttgaagtgt 8940 ggttaatgta actgagatac cgaagtttta attttattta attttaattt aaaaagccac 9000 ttgtggctgc tccatattgc acactacttt ttaaaattat tatttgtata tatttaaggg 9060 gcacaagtac aattttgttg catggattta tagcccagtg gggaagtctg ggcttttagg 9120 gtatctatta cctgaataat gtacattgta cccattgagt aatttctcat catccactct 9180 cctccactcc ccaacccttc caagtttcca ctgtctatta ttccactctc tatgtccatg 9240 cctatgcatt atttagcatt gacatgtcta tgcattattt agtcaaatac atgtgctatt 9300 tgacttcctg tatctgagtt gtttgactta agataatgac cttcacttgc atccatgttg 9360 ctgcaaaaga catgatttca ttctttttta tgcctgggtg gtattgcatt gtgtgtgtgt 9420 gtgtgtgtgt gtgtgtagag agagagagag atcacatttt ctttatacag tcctccattg 9480 atgggcactt aggttgattc catatctttg ctattgtgaa tagttttgtg ataaacacac 9540 aggttcaggt gtctttttga caaaattatt tattttcctt tgtgtagata cccagtcgtg 9600 ggattcctgg atcaaatggt agtttcattt ttagttattt gagaaatctc cacgtttttc 9660 atagagatta tactaaatta cattcccacc aacagtgtgt aacggttcac ttttcttgca 9720 tcctttttaa catctgttat ttttgtcttt ttagtaacag ccattctgac tggcgtaagg 9780 tggtatctca tcatggtttt aatctgtatt tctctgatta ttagtaatgt cgagcatttt 9840 ttcatatgct tgttagccat tggtatgtct tctacatctt taagaagctg gctatgggct 9900 gggcgcagtg gctcacacct gtaatcccag cactttggga ggccgaggca ggcggatcac 9960 gaggtcagga gttaaaaacc agcctggcca acatggtaaa accctgcctc tactaaaaat 10020 acaaaaaatt acccaggcat ggtggtgcgc ctgtaatccc agctactcag gaagctgagg 10080 caggagaatc acttgaaccc aggaggcgga ggttgcagtg agacgagatc acatcattgc 10140 actccagcct gggtgacaga gtgagactct atcttgagaa aaaaaaaaag ttggctataa 10200 cagggttgta gaagtagagg aaccagtaac ccttctcgcc atgcctgatg atggctttac 10260 atccctgtct tcatggagtt tatgctgtcg tgaggaataa caagaacagg cagttgtcaa 10320 ttataaatta tttgatgtga acctattcat acatgggtgt ggtcatcagg gaaggcttcc 10380 tggaggaaat gacattgaag gtgaattcta aaagatgacg ataaaccacc aagtgaagga 10440 gagcttaaat gtgtttttag gcagaagaaa aaccttttgg gtgaaaattt taaaacttag 10500 agaggtccca tcagtttcca actgcgatga tccattctct ccaccactgc ccttgggccc 10560 agcccaattt aggtccacca tgcccagagg catgaattta acttatgaca ctcttgtggt 10620 ggaataatgg ctttgggctt atgtagccat gtgtcatttt tttagagata caaattgaaa 10680 tatttggggt gagatgtcat ggtgtctact ggcctctaaa acttcagtga aaacatttac 10740 tttcactgaa atgtcaataa atcataaatt ggatgtatat gttttagttg gaggaaatat 10800 aaaccactaa atctaggtga tgcatattta ttatactctt ctctctgctt ttttgtacgc 10860 ttgtaaaatt gtatttaaaa gaataagaca cacttggccg ggcgcggtgg ctcacgcctg 10920 taatcccagc actttgggag accgaggtgg gtggatcatg aggtcaggag ttcaagacca 10980 gcctggccaa catggtaaaa ctccatcact acatacaaaa attagccagg cattttggcg 11040 ggcacctgta atctcagcta cttgggaggc tgaagcagga gaattgcttg aacccgggaa 11100 gcagaggttg cagtgagcca agatcacgcc actgcactct agcctgggca acagagcaag 11160 actccatctc cagaaaaaaa aaaaaaaaaa gacacactca catgcaccct ccatttcttt 11220 catttctagg gtattctccc aacagaaatg agcccttaac tgggaattct ggtaagtctc 11280 aaagaagccc cagcccaggg tagggagggg gtagcctgat ggtgctttgc cttgtccaag 11340 agcaccaggc acacagagtc ttggatgagg atcaaaattg ccaacccatg gcaaagacta 11400 ttgaggcata gtaaagggat agcagggatc ctggctttct gggggcccag tttttggggg 11460 catcagaggc atgaggtgtt gagccactaa gctctcttcc ccaggggctg tgcccatcct 11520 caggccacat agggtccaag aaggagccct gggacgtggc aggaggtggc tcaccccagc 11580 ccttgtctcc ccagaccttc ccttctgggc tgtcatcctc atcggcttgg caggactcct 11640 gggagtcatc acatgcctga tctgcggtgt cctggtgagc aaggaagggt tgcttgtctt 11700 cttaacaatt gggttgtaag agttcttaat atattataaa accatactat actatacaca 11760 agtcctttgc tggatatatg ttttgcaaat attttctccc agttcacgga gtggctttcc 11820 tattttcttt ttataatttt atttttaatt aattgacaaa taatgaatgc atatatttag 11880 gggatacaat gtgatgcttt ggtatatgta caattatgga atgactcaat caagctaatt 11940 aatatgtccc tcacctctca tacttattat ttctttgtgg tgtgaacatt ggcaacctat 12000 actcttagca attttgaaat ctacattatt attaactata gttactatgt tatgcagatc 12060 tcaaaaactt cacaacctat atgctgatta caagatattg agagaaaaag tgattgcaaa 12120 gagtgtaaat aaaataatgt aagagggaaa aatgtaacaa aattagtcgt tagggaaatg 12180 tacacggaag tcacaatgag aggccacttt tcacaagaat ggataaaatt gaaaagattg 12240 actataacaa gtgttggtga aaatgtgaca gaactggaac tctcataaag tgaaagtgga 12300 aaatagcttg gccatttctt tgaaaattac acacacctac cgtaagacct accatcccac 12360 tactagtaat ttatctaaga gaaataaaaa catatgtcta tatgaagact tgtacacaag 12420 taaatgttca taacagcttt gtttgtaata gccaaactct gaaaacaagc ccctaatgtc 12480 cattaacaaa tatatcctga caatggaata ttattcagca acaaaaagga attattaata 12540 cattaataaa ttatacagca acatgtataa attgcaaaat agttatgcct agtgaaagaa 12600 tccagatgaa gaaaagagta catgccatat gattccctta atagacaaat tctagaaaat 12660 acaaactaat ctgtaaggac aggaatcaga tcagcggttg cctgggaatg aaaatgtgtt 12720 tgcagtggca gggaaaaagg aattgtaaaa gagcaggaag aaagtttttt tgttgttttt 12780 tttttgtttt ttcttgagac agagtcttag tctatcgccc aagctggagt gcaatggcac 12840 gatctcagct cattgcaacc tctgcctctc gggttcaagc gtttttcctg ccccagcctc 12900 ccaagtagct gggattacac atgcgcacca ccacactcag ctaatttttg tatttttagt 12960 agagacgggg ttttaccatg ttggccaggc tggtctcgaa ctcctgacct caggtgatcc 13020 acccgccttg gcctcccaaa gtgctgggat tacaggagtg agccaccatg cctggccagg 13080 acgaaagttt tggggatgat ggatggatgt tccttatgtt gattgtggtg acgattcaat 13140 aagttatgat cagaacttat caaaacattc actttaaatg tgtgcagttt attttatgtc 13200 agttatgcct cagttaagct ggacagatgt agaggaggaa gggagggaga gagggggctg 13260 agatcaggac caaaagccag agagaaagag actgagaatg agatgagaga gaaatggtat 13320 ttagacagaa gacaggcgat agatgattga tagttgacag atgattggtg gatannnnnn 13380 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13440 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13500 aggaggttta aacaaaacgc aattatgttg aaatgacaat gattgtggat ataaaggtag 13560 atagaaatag atatttgtga agataatggt tagataaaaa tgataggtaa cagatattga 13620 tagatcttga taagtagatg ataaatacat gattgatgga tgacaggtga ttgatagatg 13680 atttgatgga ttataaatag gagatgattg agaggtgaga gataattgat ggttatttga 13740 ttggtagata attgattgac aggttgataa atattgatag ctagatgata gataaataga 13800 tcattggtag atatgtgata tattgataaa gaaattcaga ggcaaaagga gagagaaatg 13860 aaggggatat cggaggggga aaaatttttt taaaccgaga gtgaaacaag gagacagaag 13920 aaaagaaagt ggtgaaaaga ggaaaagaac tgagggagaa attaaatgaa acaatgaagg 13980 gagacagagg aagcataagg cctctggctt tggccatatt ctcacccctg tggtctcctc 14040 tccctggacg gctgaccagt ccattctcac gcctcctcct caccctcata ggtgaccacc 14100 cgccggcgga agaaggaagg agaatacaac gtccagcaac agtgcccagg ctactaccag 14160 tcacacctag acctggagga tctgcaatga ctggaacttg ccggtgcctg gggtgccttt 14220 cccccagcca gggtccaaag aagcttggct ggggcagaaa taaaccatat tggtcgg 14277 4 66765 DNA Homo sapiens misc_feature (38757)..(38757) n is a, c, g, or t 4 aagcgttgca caattccccc aacctccata catacggcag ctcttctaga cacaggtttt 60 cccaggtcaa atgcggggac cccagccata tctcccaccc tgagaaattt tggagtttca 120 gggagctcag aagctctgca gaggccaccc tctctgaggg gattcttctt agacctccat 180 ccagaggcaa atgttgacct gtccatgctg aaaccctcag gccttcctgg gtcatcttct 240 cccacccgct ccttgatgac agggagcagg agcactaaag ccacaccaga aatggattca 300 ggactgacag gagccacctt gtcacctaag acatctacag gtgcaatcgt ggtgacagaa 360 catactctgc cctttacttc cccagataag accttggcca gtcctacatc ttcggttgtg 420 ggaagaacca cccagtcttt gggggtgatg tcctctgctc tccctgagtc aacctctaga 480 ggaatgacac actccgagca aagaaccagc ccatcgctga gtccccaggt caatggaact 540 ccctctagga actaccctgc tacaagcatg gtttcaggat tgagttcccc aaggaccagg 600 accagttcca cagaaggaaa ttttaccaaa gaagcatcta catacacact cactgtagag 660 accacaagtg gcccagtcac tgagaagtac acagtcccca ctgagacctc aacaactgaa 720 ggtgacagca cagagacccc ctgggacaca agatatattc ctgtaaaaat cacatctcca 780 atgaaaacat ttgcagattc aactgcatcc aaggaaaatg ccccagtgtc tatgactcca 840 gctgagacca cagttactga ctcacatact ccaggaagga caaacccatc atttgggaca 900 ctttattctt ccttccttga cctatcacct aaagggaccc caaattccag aggtgaaaca 960 agcctggaac tgattctatc aaccactgga tatcccttct cctctcctga acctggctct 1020 gcaggacaca gcagaataag taccagtgcg cctttgtcat catctgcttc agttctcgat 1080 aataaaatat cagagaccag catattctca ggccagagtc tcacctcccc tctgtctcct 1140 ggggtgcccg aggccagagc cagcacaatg cccaactcag ctatcccttt ttccatgaca 1200 ctaagcaatg cagaaacaag tgccgaaagg gtcagaagca caatttcctc tctggggact 1260 ccatcaatat ccacaaagca gacagcagag actatcctta ccttccatgc cttcgctgag 1320 accatggata tacccagcac ccacatagcc aagactttgg cttcagaatg gttgggaagt 1380 ccaggtaccc ttggtggcac cagcacttca gcgctgacaa ccacatctcc atctaccact 1440 ttagtctcag aggagaccaa cacccatcac tccacgagtg gaaaggaaac agaaggaact 1500 ttgaatacat ctatgactcc acttgagacc tctgctcctg gagaagagtc cgaaatgact 1560 gccaccttgg tccccactct aggttttaca actcttgaca gcaagatcag aagtccatct 1620 caggtctctt catcccaccc aacaagagag ctcagaacca caggcagcac ctctgggagg 1680 cagagttcca gcacagctgc ccacgggagc tctgacatcc tgagggcaac cacttccagc 1740 acctcaaaag catcatcatg gaccagtgaa agcacagctc agcaatttag tgaaccccag 1800 cacacacagt gggtggagac aagtcctagc atgaaaacag agagaccccc agcatcaacc 1860 agtgtggcag cccctatcac cacttctgtt ccctcagtgg tctctggctt caccaccctg 1920 aagaccagct ccacaaaagg gatttggctt gaagaaacat ctgcagacac actcatcgga 1980 gaatccacag ctggcccaac cacccatcag tttgctgttc ccactgggat ttcaatgaca 2040 ggaggcagca gcaccagggg aagccagggc acaacccacc tactcaccag agccacagca 2100 tcatctgaga catccgcaga tttgactctg gccacgaacg gtgtcccagt ctccgtgtct 2160 ccagcagtga gcaagacggc tgctggctca agtcctccag gagggacaaa gccatcatat 2220 acaatggttt cttctgtcat ccctgagaca tcatctctac agtcctcagc tttcagggaa 2280 ggaaccagcc tgggactgac tccattaaac actagacatc ccttctcttc ccctgaacca 2340 gactctgcag gacacaccaa gataagcacc agcattcctc tgttgtcatc tgcttcagtt 2400 cttgaggata aagtgtcagc gaccagcaca ttctcacacc acaaagccac ctcatctatt 2460 accacaggga ctcctgaaat ctcaacaaag acaaagccca gctcagccgt tctttcctcc 2520 atgaccctaa gcaatgcagc aacaagtcct gaaagagtca gaaatgcaac ttcccctctg 2580 actcatccat ctccatcagg ggaagagaca gcagggagtg tcctcactct cagcacctct 2640 gctgagacta cagactcacc taacatccac ccaactggga cactgacttc agaatcgtca 2700 gagagtccta gcactctcag cctcccaagt gtctctggag tcaaaaccac attttcttca 2760 tctactcctt ccactcatct atttactagt ggagaagaaa cagaggaaac ttcgaatcca 2820 tctgtgtctc aacctgagac ttctgtttcc agagtaagga ccaccttggc cagcacctct 2880 gtccctaccc cagtattccc caccatggac acctggccta cacgttcagc tcagttctct 2940 tcatcccacc tagtgagtga gctcagagct acgagcagta cctcagttac aaactcaact 3000 ggttcagctc ttcctaaaat atctcacctc actgggacgg caacaatgtc acagaccaat 3060 agagacacgt ttaatgactc tgctgcaccc caaagcacaa cttggccaga gactagtccc 3120 agattcaaga cagggttacc ttcagcaaca accactgttt caacctctgc cacttctctc 3180 tctgctactg taatggtctc taaattcact tctccagcaa ctagttccat ggaagcaact 3240 tctatcaggg aaccatcaac aaccatcctc acaacagaga ccacgaatgg cccaggctct 3300 atggctgtgg cttctaccaa catcccaatt ggaaagggct acattactga aggaagattg 3360 gacacaagcc atctgcccat tggaaccaca gcttcctctg agacatctat ggattttacc 3420 atggccaaag aaagtgtctc aatgtcagta tctccatctc agtccatgga tgctgctggc 3480 tcaagcactc caggaaggac aagccaattc gttgacacat tttctgatga tgtctatcat 3540 ttaacatcca gagaaattac aatacctaga gatggaacaa gctcagctct gactccacaa 3600 atgactgcaa ctcaccctcc atctcctgat cctggctctg ctagaagcac ctggcttggc 3660 atcttgtcct catctccttc ttctcctact cccaaagtca caatgagctc cacattttca 3720 actcagagag tcaccacaag catgataatg gacacagttg aaactagtcg gtggaacatg 3780 cccaacttac cttccacgac ttccctgaca ccaagtaata ttccaacaag tggtgccata 3840 ggaaaaagca ccctggttcc cttggacact ccatctccag ccacatcatt ggaggcatca 3900 gaagggggac ttccaaccct cagcacctac cctgaatcaa caaacacacc cagcatccac 3960 ctcggagcac acgctagttc agaaagtcca agcaccatca aacttaccat ggcttcagta 4020 gtaaaacctg gctcttacac acctctcacc ttcccctcaa tagagaccca cattcatgta 4080 tcaacagcca gaatggctta ctcttctggg tcttcacctg agatgacagc tcctggagag 4140 actaacactg gtagtacctg ggaccccacc acctacatca ccactacgga tcctaaggat 4200 acaagttcag ctcaggtctc tacaccccac tcagtgagga cactcagaac cacagaaaac 4260 catccaaaga cagagtccgc caccccagct gcttactctg gaagtcctaa aatctcaagt 4320 tcacccaatc tcaccagtcc ggccacaaaa gcatggacca tcacagacac aactgaacac 4380 tccactcaat tacattacac aaaattggca gaaaaatcat ctggatttga gacacagtca 4440 gctccaggac ctgtctctgt agtaatccct acctccccta ccattggaag cagcacattg 4500 gaactaactt ctgatgtccc aggggaaccc ctggtccttg ctcccagtga gcagaccaca 4560 atcactctcc ccatggcaac atggctgagt accagtttga cagaggaaat ggcttcaaca 4620 gaccttgata tttcaagtcc aagttcaccc atgagtacat ttgctatttt tccacctatg 4680 tccacacctt ctcatgaact ttcaaagtca gaggcagata ccagtgccat tagaaataca 4740 gattcaacaa cgttggatca gcacctagga atcaggagtt tgggcagaac tggggactta 4800 acaactgttc ctatcacccc actgacaacc acgtggacca gtgtgattga acactcaaca 4860 caagcacagg acaccctttc tgcaacgatg agtcctactc acgtgacaca gtcactcaaa 4920 gatcaaacat ctataccagc ctcagcatcc ccttcccatc ttactgaagt ctaccctgag 4980 ctcgggacac aagggagaag ctcctctgag gcaaccactt tttggaaacc atctacagac 5040 acactgtcca gagagattga gactggccca acaaacattc aatccactcc acccatggac 5100 aacacaacaa cagggagcag tagtagtgga gtcaccctgg gcatagccca ccttcccata 5160 ggaacatcct ccccagctga gacatccaca aacatggcac tggaaagaag aagttctaca 5220 gccactgtct ctatggctgg gacaatggga ctccttgtta ctagtgctcc aggaagaagc 5280 atcagccagt cattaggaag agtttcctct gtcctttctg agtcaactac tgaaggagtc 5340 acagattcta gtaagggaag cagcccaagg ctgaacacac agggaaatac agctctctcc 5400 tcctctcttg aacccagcta tgctgaagga agccagatga gcacaagcat ccctctaacc 5460 tcatctccta caactcctga tgtggaattc atagggggca gcacattttg gaccaaggag 5520 gtcaccacag ttatgacctc agacatctcc aagtcttcag caaggacaga gtccagctca 5580 gctaccctta tgtccacagc tttgggaagc actgaaaata caggaaaaga aaaactcaga 5640 actgcctcta tggatcttcc atctccaact ccatcaatgg aggtgacacc atggatttct 5700 ctcactctca gtaatgcccc caataccaca gattcacttg acctcagcca tggggtgcac 5760 accagctctg cagggacttt ggccactgac aggtcattga atactggtgt cactagagcc 5820 tccagattgg aaaacggctc tgatacctct tctaagtccc tgtctatggg aaacagcact 5880 cacacttcca tgactgacac agagaagagt gaagtgtctt cttcaatcca tccccgacct 5940 gagacctcag ctcctggagc agagaccact ttgacttcca ctcctggaaa cagggccata 6000 agcttaacat tgcctttttc atccattcca gtggaagaag tcatttctac aggcataacc 6060 tcaggaccag acatcaactc agcacccatg acacattctc ccatcacccc accaacaatt 6120 gtatggacca gtacaggcac aattgaacag tccactcaac cactacatgc agtttcttca 6180 gaaaaagttt ctgtgcagac acagtcaact ccatatgtca actctgtggc agtgtctgct 6240 tcccctaccc atgagaattc agtctcttct ggaagcagca catcctctcc atattcctca 6300 gcctcacttg aatccttgga ttccacaatc agtaggagga atgcaatcac ttcctggcta 6360 tgggacctca ctacatctct ccccactaca acttggccaa gtactagttt atctgaggca 6420 ctgtcctcag gccattctgg ggtttcaaac ccaagttcaa ctacgactga atttccactc 6480 ttttcagctg catccacatc tgctgctaag caaagaaatc cagaaacaga gacccatggt 6540 ccccagaata cagccgcgag tactttgaac actgatgcat cctcggtcac aggtctttct 6600 gagactcctg tgggggcaag tatcagctct gaagtccctc ttccaatggc cataacttct 6660 agatcagatg tttctggcct tacatctgag agtactgcta acccgagttt aggcacagcc 6720 tcttcagcag ggaccaaatt aactaggaca atatccctgc ccacttcaga gtctttggtt 6780 tcctttagaa tgaacaagga tccatggaca gtgtcaatcc ctttggggtc ccatccaact 6840 actaatacag aaacaagcat cccagtaaac agcgcaggtc cacctggctt gtccacagta 6900 gcatcagatg taattgacac accttcagat ggggctgaga gtattcccac tgtctccttt 6960 tccccctccc ctgatactga agtgacaact atctcacatt tcccagaaaa gacaactcat 7020 tcatttagaa ccatttcatc tctcactcat gagttgactt caagagtgac acctattcct 7080 ggggattgga tgagttcagc tatgtctaca aagcccacag gagccagtcc ctccattaca 7140 ctgggagaga gaaggacaat cacctctgct gctccaacca cttcccccat agttctcact 7200 gctagtttca cagagaccag cacagtttca ctggataatg aaactacagt aaaaacctca 7260 gatatccttg acgcacggaa aacaaatgag ctcccctcag atagcagttc ttcttctgat 7320 ctgatcaaca cctccatagc ttcttcaact atggatgtca ctaaaacagc ctccatcagt 7380 cccactagca tctcaggaat gacagcaagt tcctccccat ctctcttctc ttcagataga 7440 ccccaggttc ccacatctac aacagagaca aatacagcca cctctccatc tgtttccagt 7500 aacacctatt ctcttgatgg gggctccaat gtgggtggca ctccatccac tttaccaccc 7560 tttacaatca cccaccctgt cgagacaagc tcggccctat tagcctggtc tagaccagta 7620 agaactttca gcaccatggt cagcactgac actgcctccg gagaaaatcc tacctctagc 7680 aattctgtgg tgacttctgt tccagcacca ggtacatggg ccagtgtagg cagtactact 7740 gacttacctg ccatgggctt tctcaagaca agtcctgcag gagaggcaca ctcacttcta 7800 gcatcaacta ttgaaccagc cactgccttc actccccatc tctcagcagc agtggtcact 7860 ggatccagtg ctacatcaga agccagtctt ctcactacga gtgaaagcaa agccattcat 7920 tcttcaccac agaccccaac tacacccacc tctggagcaa actgggaaac ttcagctact 7980 cctgagagcc ttttggtagt cactgagact tcagacacaa cacttacctc aaagattttg 8040 gtcacagata ccatcttgtt ttcaactgtg tccacgccac cttctaaatt tccaagtacg 8100 gggactctgt ctggagcttc cttccctact ttactcccgg acactccagc catccctctc 8160 actgccactg agccaacaag ttcattagct acatcctttg attccacccc actggtgact 8220 atagcttcgg atagtcttgg cacagtccca gagactaccc tgaccatgtc agagacctca 8280 aatggtgatg cactggttct taagacagta agtaacccag ataggagcat ccctggaatc 8340 actatccaag gagtaacaga aagtccactc catccttctt ccacttcccc ctctaagatt 8400 gttgctccac ggaatacaac ctatgaaggt tcgatcacag tggcactttc tactttgcct 8460 gcgggaacta ctggttccct tgtattcagt cagagttctg aaaactcaga gacaacggct 8520 ttggtagact catcagctgg gcttgagagg gcatctgtga tgccactaac cacaggaagc 8580 cagggtatgg ctagctctgg aggaatcaga agtgggtcca ctcactcaac tggaaccaaa 8640 acattttctt ctctccctct gaccatgaac ccaggtgagg ttacagccat gtctgaaatc 8700 accacgaaca gactgacagc tactcaatca acagcaccca aagggatacc tgtgaagccc 8760 accagtgctg agtcaggcct cctaacacct gtctctgcct cctcaagccc atcaaaggcc 8820 tttgcctcac tgactacagc tcccccatca acttggggga tcccacagtc taccttgaca 8880 tttgagtttt ctgaggtccc aagtttggat actaagtccg cttctttacc aactcctgga 8940 cagtccctga acaccattcc agactcagat gcaagcacag catcttcctc actgtccaag 9000 tctccagaaa aaaacccaag ggcaaggatg atgacttcca caaaggccat aagtgcaagc 9060 tcatttcaat caacaggttt tactgaaacc cctgagggat ctgcctcccc ttctatggca 9120 gggcatgaac ccagagtccc cacttcagga acaggggacc ctagatatgc ctcagagagc 9180 atgtcttatc cagacccaag caaggcatca tcagctatga catcgacctc tcttgcatca 9240 aaactcacaa ctctcttcag cacaggtcaa gcagcaaggt ctggttctag ttcctctccc 9300 ataagcctat ccactgagaa agaaacaagc ttcctttccc ccactgcatc cacctccaga 9360 aagacttcac tatttcttgg gccttccatg gcaaggcagc ccaacatatt ggtgcatctt 9420 cagacttcag ctctgacact ttctccaaca tccactctaa atatgtccca ggaggagcct 9480 cctgagttaa cctcaagcca gaccattgca gaagaagagg gaacaacagc tgaaacacag 9540 acgttaacct tcacaccatc tgagacccca acatccttgt tacctgtctc ttctcccaca 9600 gaacccacag ccagaagaaa gagttctcca gaaacatggg caagctctat ttcagttcct 9660 gccaagacct ccttggttga aacaactgat ggaacgctag tgaccaccat aaagatgtca 9720 agccaggcag cacaaggaaa ttccacgtgg cctgccccag cagaggagac ggggaccagt 9780 ccagcaggca catccccagg aagcccagaa gtgtctacca ctctcaaaat catgagctcc 9840 aaggaaccca gcatcagccc agagatcagg tccactgtgc gaaattctcc ttggaagact 9900 ccagaaacaa ctgttcccat ggagaccaca gtggaaccag tcacccttca gtccacagcc 9960 ctaggaagtg gcagcaccag catctctcac ctgcccacag gaaccacatc accaaccaag 10020 tcaccaacag aaaatatgtt ggctacagaa agggtctccc tctccccatc cccacctgag 10080 gcttggacca acctttattc tggaactcca ggagggacca ggcagtcact ggccacaatg 10140 tcctctgtct ccctagagtc accaactgct agaagcatca cagggactgg tcagcaaagc 10200 agtccagaac tggtttcaaa gacaactgga atggaattct ctatgtggca tggctctact 10260 ggagggacca caggggacac acatgtctct ctgagcacat cttccaatat ccttgaagac 10320 cctgtaacca gcccaaactc tgtgagctca ttgacagata aatccaaaca taaaaccgag 10380 acatgggtaa gcaccacagc cattccctcc actgtcctga ataataagat aatggcagct 10440 gaacaacaga caagtcgatc tgtggatgag gcttattcat caactagttc ttggtcagat 10500 cagacatctg ggagtgacat cacccttggt gcatctcctg atgtcacaaa cacattatac 10560 atcacctcca cagcacaaac cacctcacta gtgtctctgc cctctggaga ccaaggcatt 10620 acaagcctca ccaatccctc aggaggaaaa acaagctctg cgtcatctgt cacatctcct 10680 tcaatagggc ttgagactct gagggccaat gtaagtgcag tgaaaagtga cattgcccct 10740 actgctgggc atctatctca gacttcatct cctgcggaag tgagcatcct ggacgtaacc 10800 acagctccta ctccaggtat ctccaccacc atcaccacca tgggaaccaa ctcaatctca 10860 actaccacac ccaacccaga agtgggtatg agtaccatgg acagcacccc ggccacagag 10920 aggcgcacaa cttctacaga acacccttcc acctggtctt ccacagctgc atcagattcc 10980 tggactgtca cagacatgac ttcaaacttg aaagttgcaa gatctcctgg aacaatttcc 11040 acaatgcata caacttcatt cttagcctca agcactgaat tagactccat gtctactccc 11100 catggccgta taactgtcat tggaaccagc ctggtcactc catcctctga tgcttcagct 11160 gtaaagacag agaccagtac aagtgaaaga acattgagtc cttcagacac aactgcatct 11220 actcccatct caactttttc tcgtgtccag aggatgagca tctcagttcc tgacatttta 11280 agtacaagtt ggactcccag tagtacagaa gcagaagatg tgcctgtttc aatggtttct 11340 acagatcatg ctagtacaaa gactgaccca aatacgcccc tgtccacttt tctgtttgat 11400 tctctgtcca ctcttgactg ggacactggg agatctctgt catcagccac agccactacc 11460 tcagctcctc agggggccac aactccccag gaactcactt tggaaaccat gatcagccca 11520 gctacctcac agttgccctt ctctataggg cacattacaa gtgcagtcac accagctgca 11580 atggcaagga gctctggagt tactttttca agaccagatc ccacaagcaa aaaggcagag 11640 cagacttcca ctcagcttcc caccaccact tctgcacatc cagggcaggt gcccagatca 11700 gcagcaacaa ctctggatgt gatcccacac acagcaaaaa ctccagatgc aacttttcag 11760 agacaagggc agacagctct tacaacagag gcaagagcta catctgactc ctggaatgag 11820 aaagaaaaat caaccccaag tgcaccttgg atcactgaga tgatgaattc tgtctcagaa 11880 gataccatca aggaggttac cagctcctcc agtgtattaa aggaccctga atacgctgga 11940 cataaacttg gaatctggga cgacttcatc cccaagtttg gaaaagcagc ccatatgaga 12000 gagttgcccc ttctgagtcc accacaggac aaagaggcaa ttcacccttc tacaaacaca 12060 gtagagacca caggctgggt cacaagttcc gaacatgctt ctcattccac tatcccagcc 12120 cactcagcgt catccaaact cacatctcca gtggttacaa cctccaccag ggaacaagca 12180 atagtttcta tgtcaacaac cacatggcca gagtctacaa gggctagaac agagcctaat 12240 tccttcttga ctattgaact gagggacgtc agcccttaca tggacaccag ctcaaccaca 12300 caaacaagta ttatctcttc cccaggttcc actgcgatca ccaaggggcc tagaacagaa 12360 attacctcct ctaagagaat atccagctca ttccttgccc agtctatgag gtcgtcagac 12420 agcccctcag aagccatcac caggctgtct aactttcctg ccatgacaga atctggagga 12480 atgatccttg ctatgcaaac aagtccacct ggcgctacat cactaagtgc acctactttg 12540 gatacatcag ccacagcctc ctggacaggg actccactgg ctacgactca gagatttaca 12600 tactcagaga agaccactct ctttagcaaa ggtcctgagg atacatcaca gccaagccct 12660 ccctctgtgg aagaaaccag ctcttcctct tccctggtac ctatccatgc tacaacctcg 12720 ccttccaata ttttgttgac atcacaaggg cacagtccct cctctactcc acctgtgacc 12780 tcagttttct tgtctgagac ctctggcctg gggaagacca cagacatgtc gaggataagc 12840 ttggaacctg gcacaagttt acctcccaat ttgagcagta cagcaggtga ggcgttatcc 12900 acttatgaag cctccagaga tacaaaggca attcatcatt ctgcagacac agcagtgacg 12960 aatatggagg caaccagttc tgaatattct cctatcccag gccatacaaa gccatccaaa 13020 gccacatctc cattggttac ctcccacatc atgggggaca tcacttcttc cacatcagta 13080 tttggctcct ccgagaccac agagattgag acagtgtcct ctgtgaacca gggacttcag 13140 gagagaagca catcccaggt ggccagctct gctacagaga caagcactgt cattacccat 13200 gtgtctagtg gtgatgctac tactcatgtc accaagacac aagccacttt ctctagcgga 13260 acatccatct caagccctca tcagtttata acttctacca acacatttac agatgtgagc 13320 accaacccct ccacctctct gataatgaca gaatcttcag gagtgaccat caccacccaa 13380 acaggtccta ctggagctgc aacacagggt ccatatctct tggacacatc aaccatgcct 13440 tacttgacag agactccatt agctgtgact ccagatttta tgcaatcaga gaagaccact 13500 ctcataagca aaggtcccaa ggatgtgacc tggacaagcc ctccctctgt ggcagaaacc 13560 agctatccct cttccctgac acctttcttg gtcacaacca tacctcctgc cacttccacg 13620 ttacaagggc aacatacatc ctctcctgtt tctgcgactt cagttcttac ctctggactg 13680 gtgaagacca cagatatgtt gaacacaagc atggaacctg tgaccaattc acctcaaaat 13740 ttgaacaatc catcaaatga gatactggcc actttggcag ccaccacaga tatagagact 13800 attcatcctt ccataaacaa agcagtgacc aatatgggga ctgccagttc agcacatgta 13860 ctgcattcca ctctcccagt cagctcagaa ccatctacag ccacatctcc aatggttcct 13920 gcctccagca tgggggacgc tcttgcttct atatcaatac ctggttctga gaccacagac 13980 attgagggag agccaacatc ctccctgact gctggacgaa aagagaacag caccctccag 14040 gagatgaact caactacaga gtcaaacatc atcctctcca atgtgtctgt gggggctatt 14100 actgaagcca caaaaatgga agtcccctct tttgatgcaa cattcatacc aactcctgct 14160 cagtcaacaa agttcccaga tattttctca gtagccagca gtagactttc aaactctcct 14220 cccatgacaa tatctaccca catgaccacc acccagacag ggtcttctgg agctacatca 14280 aagattccac ttgccttaga cacatcaacc ttggaaacct cagcagggac tccatcagtg 14340 gtgactgagg ggtttgccca ctcaaaaata accactgcaa tgaacaatga tgtcaaggac 14400 gtgtcacaga caaaccctcc ctttcaggat gaagccagct ctccctcttc tcaagcacct 14460 gtccttgtca caaccttacc ttcttctgtt gctttcacac cgcaatggca cagtacctcc 14520 tctcctgttt ctatgtcctc agttcttact tcttcactgg taaagaccgc aggcaaggtg 14580 gatacaagct tagaaacagt gaccagttca cctcaaagta tgagcaacac tttggatgac 14640 atatcggtca cttcagcagc caccacagat atagagacaa cgcatccttc cataaacaca 14700 gtagttacca atgtggggac caccggttca gcatttgaat cacattctac tgtctcagct 14760 tacccagagc catctaaagt cacatctcca aatgttacca cctccaccat ggaagacacc 14820 acaatttccc gatcaatacc taaatcctct aagactacaa gaactgagac tgagacaact 14880 tcctccctga ctcctaaact gagggagacc agcatctccc aggagatcac ctcgtccaca 14940 gagacaagca ctgttcctta caaagagctc actggtgcca ctaccgaggt atccaggaca 15000 gatgtcactt cctctagcag tacatccttc cctggccctg atcagtccac agtgtcacta 15060 gacatctcca cagaaaccaa caccaggctg tctacctccc caataatgac agaatctgca 15120 gaaataacca tcaccaccca aacaggtcct catggggcta catcacagga tacttttacc 15180 atggacccat caaatacaac cccccaggca gggatccact cagctatgac tcatggattt 15240 tcacaattgg atgtgaccac tcttatgagc agaattccac aggatgtatc atggacaagt 15300 cctccctctg tggataaaac cagctccccc tcttcctttc tgtcctcacc tgcaatgacc 15360 acaccttccc tgatttcttc taccttacca gaggataagc tctcctctcc tatgacttca 15420 cttctcacct ctggcctagt gaagattaca gacatattac gtacacgctt ggaacctgtg 15480 accagctcac ttccaaattt cagcagcacc tcagataaga tactggccac ttctaaagac 15540 agtaaagaca caaaggaaat ttttccttct ataaacacag aagagaccaa tgtgaaagcc 15600 aacaactctg gacatgaatc ccattcccct gcactggctg actcagagac acccaaagcc 15660 acaactcaaa tggttatcac caccactgtg ggagatccag ctccttccac atcaatgcca 15720 gtgcatggtt cctctgagac tacaaacatt aagagagagc caacatattt cttgactcct 15780 agactgagag agaccagtac ctctcaggag tccagctttc ccacggacac aagttttcta 15840 ctttccaaag tccccactgg tactattact gaggtctcca gtacaggggt caactcttct 15900 agcaaaattt ccaccccaga ccatgataag tccacagtgc cacctgacac cttcacagga 15960 gagatcccca gggtcttcac ctcctctatt aagacaaaat ctgcagaaat gacgatcacc 16020 acccaagcaa gtcctcctga gtctgcatcg cacagtaccc ttcccttgga cacatcaacc 16080 acactttccc agggagggac tcattcaact gtgactcagg gattcccata ctcagaggtg 16140 accactctca tgggcatggg tcctgggaat gtgtcatgga tgacaactcc ccctgtggaa 16200 gaaaccagct ctgtgtcttc cctgatgtct tcacctgcca tgacatcccc ttctcctgtt 16260 tcctccacat caccacagag catcccctcc tctcctcttc ctgtgactgc acttcctact 16320 tctgttctgg tgacaaccac agatgtgttg ggcacaacaa gcccagagtc tgtaaccagt 16380 tcacctccaa atttgagcag catcactcat gagagaccgg ccacttacaa agacactgca 16440 cacacagaag ccgccatgca tcattccaca aacaccgcag tgaccaatgt agggacttcc 16500 gggtctggac ataaatcaca atcctctgtc ctagctgact cagagacatc gaaagccaca 16560 cctctgatga gtaccacctc caccctgggg gacacaagtg tttccacatc aactcctaat 16620 atctctcaga ctaaccaaat tcaaacagag ccaacagcat ccctgagccc tagactgagg 16680 gagagcagca cgtctgagaa gaccagctca acaacagaga caaatactgc cttttcttat 16740 gtgcccacag gtgctattac tcaggcctcc agaacagaaa tctcctctag cagaacatcc 16800 atctcagacc ttgatcggcc cacaatagca cccgacatct ccacaggaat gatcaccagg 16860 ctcttcacct cccccatcat gacaaaatct gcagaaatga ccgtcaccac tcaaacaact 16920 actcctgggg ctacatcaca gggtatcctt ccttgggaca catcaaccac acttttccag 16980 ggagggactc attcaaccgt gtctcaggga ttcccacact cagagataac cactcttcgg 17040 agcagaaccc ctggagatgt gtcatggatg acaactcccc ctgtggaaga aaccagctct 17100 gggttttccc tgatgtcacc ttccatgaca tccccttctc ctgtttcctc cacatcacca 17160 gagagcatcc cctcctctcc tctccctgtg actgcacttc ttacttctgt tctggtgaca 17220 accaccaatg tattgggcac aacaagccca gagaccgtaa cgagttcacc tccaaattta 17280 agcagcccca cacaggagag actgaccact tacaaagaca ctgcgcacac agaagccatg 17340 catgcttcca tgcatacaaa cactgcagtg gccaacgtcg ggacctccat ttctggacat 17400 gaatcacaat cttctgtccc agctgattca cacacatcca aagccacatc tccaatgggt 17460 atcaccttcg ccatggggga tacaagtgtt tctacatcaa ctcctgcctt ctttgagact 17520 agaattcaga ctgaatcaac atcctctttg attcctggat taagggacac caggacgtct 17580 gaggagatca acactgtgac agagaccagc actgtccttt cagaagtgcc cactactact 17640 actactgagg tctccaggac agaagttatc acttccagca gaacaaccat ctcagggcct 17700 gatcattcca aaatgtcacc ctacatctcc acagaaacca tcaccaggct ctccactttt 17760 ccttttgtaa caggatccac agaaatggcc atcaccaacc aaacaggtcc tatagggact 17820 atctcacagg ctacccttac cctggacaca tcaagcacag cttcctggga agggactcac 17880 tcacctgtga ctcagagatt tccacactca gaggagacca ctactatgag cagaagtact 17940 aagggcgtgt catggcaaag ccctccctct gtggaagaaa ccagttctcc ttcttcccca 18000 gtgcctttac ctgcaataac ctcacattca tctctttatt ccgcagtatc aggaagtagc 18060 cccacttctg ctctccctgt gacttccctt ctcacctctg gcaggaggaa gaccatagac 18120 atgttggaca cacactcaga acttgtgacc agctccttac caagtgcaag tagcttctca 18180 ggtgagatac tcacttctga agcctccaca aatacagaga caattcactt ttcagagaac 18240 acagcagaaa ccaatatggg gaccaccaat tctatgcata aactacattc ctctgtctca 18300 atccactccc agccatccgg acacacacct ccaaaggtta ctggatctat gatggaggac 18360 gctattgttt ccacatcaac acctggttct cctgagacta aaaatgttga cagagactca 18420 acatcccctc tgactcctga actgaaagag gacagcaccg ccctggtgat gaactcaact 18480 acagagtcaa acactgtttt ctccagtgtg tccctggatg ctgctactga ggtctccagg 18540 gcagaagtca cctactatga tcctacattc atgccagctt ctgctcagtc aacaaagtcc 18600 ccagacattt cacctgaagc cagcagcagt cattctaact ctcctccctt gacaatatct 18660 acacacaaga ccatcgccac acaaacaggt ccttctgggg tgacatctct tggccaactg 18720 accctggaca catcaaccat agccacctca gcaggaactc catcagccag aactcaggat 18780 tttgtagatt cagaaacaac cagtgtcatg aacaatgatc tcaatgatgt gttgaagaca 18840 agccctttct ctgcagaaga agccaactct ctctcttctc aggcacctct ccttgtgaca 18900 acctcacctt ctcctgtaac ttccacattg caagagcaca gtacctcctc tcttgtttct 18960 gtgacctcag tacccacccc tacactggcg aagatcacag acatggacac aaacttagaa 19020 cctgtgactc gttcacctca aaatttaagg aacaccttgg ccacttcaga agccaccaca 19080 gatacacaca caatgcatcc ttctataaac acagcaatgg ccaatgtggg gaccaccagt 19140 tcaccaaatg aattctattt tactgtctca cctgactcag acccatataa agccacatcc 19200 gcagtagtta tcacttccac ctcgggggac tcaatagttt ccacatcaat gcctagatcc 19260 tctgcgatga aaaagattga gtctgagaca actttctccc tgatatttag actgagggag 19320 actagcacct cccagaaaat tggctcatcc tcagacacaa gcacggtctt tgacaaagca 19380 ttcactgctg ctactactga ggtctccaga acagaactca cctcctctag cagaacatcc 19440 atccaaggca ctgaaaagcc cacaatgtca ccggacacct ccacaagatc tgtcaccatg 19500 ctttctactt ttgctggcct gacaaaatcc gaagaaagga ccattgccac ccaaacaggt 19560 cctcataggg cgacatcaca gggtaccctt acctgggaca catcaatcac aacctcacag 19620 gcagggaccc actcagctat gactcatgga ttttcacaat tagatttgtc cactcttacg 19680 agtagagttc ctgagtacat atcagggaca agcccaccct ctgtggaaaa aaccagctct 19740 tcctcttccc ttctgtcttt accagcaata acctcaccgt cccctgtacc tactacatta 19800 ccagaaagta ggccgtcttc tcctgttcat ctgacttcac tccccacctc tggcctagtg 19860 aagaccacag atatgctggc atctgtggcc agtttacctc caaacttggg cagcacctca 19920 cataagatac cgactacttc agaagacatt aaagatacag agaaaatgta tccttccaca 19980 aacatagcag taaccaatgt ggggaccacc acttctgaaa aggaatctta ttcgtctgtc 20040 ccagcctact cagaaccacc caaagtcacc tctccaatgg ttacctcttt caacataagg 20100 gacaccattg tttccacatc catgcctggc tcctctgaga ttacaaggat tgagatggag 20160 tcaacattct ccgtggctca tgggctgaag ggaaccagca cctcccagga ccccatcgta 20220 tccacagaga aaagtgctgt ccttcacaag ttgaccactg gtgctactga gacctctagg 20280 acagaagttg cctcttctag aagaacatcc attccaggcc ctgatcattc cacagagtca 20340 ccagacatct ccactgaagt gatccccagc ctgcctatct cccttggcat tacagaatct 20400 tcaaatatga ccatcatcac tcgaacaggt cctcctcttg gctctacatc acagggcaca 20460 tttaccttgg acacaccaac tacatcctcc agggcaggaa cacactcgat ggcgactcag 20520 gaatttccac actcagaaat gaccactgtc atgaacaagg accctgagat tctatcatgg 20580 acaatccctc cttctataga gaaaaccagc ttctcctctt ccctgatgcc ttcaccagcc 20640 atgacttcac ctcctgtttc ctcaacatta ccaaagacca ttcacaccac tccttctcct 20700 atgacctcac tgctcacccc tagcctagtg atgaccacag acacattggg cacaagccca 20760 gaacctacaa ccagttcacc tccaaatttg agcagtacct cacatgtgat actgacaaca 20820 gatgaagaca ccacagctat agaagccatg catccttcca caagcacagc agcgactaat 20880 gtggaaacca cctgttctgg acatgggtca caatcctctg tcctaactga ctcagaaaaa 20940 accaaggcca cagctccaat ggataccacc tccaccatgg ggcatacaac tgtttccaca 21000 tcaatgtctg tttcctctga gactacaaaa attaagagag agtcaacata ttccttgact 21060 cctggactga gagagaccag catttcccaa aatgccagct tttccactga cacaagtatt 21120 gttctttcag aagtccccac tggtactact gctgaggtct ccaggacaga agtcacctcc 21180 tctggtagaa catccatccc tggcccttct cagtccacag ttttgccaga aatatccaca 21240 agaacaatga caaggctctt tgcctcgccc accatgacag aatcagcaga aatgaccatc 21300 cccactcaaa caggtccttc tgggtctacc tcacaggata cccttacctt ggacacatcc 21360 accacaaagt cccaggcaaa gactcattca actttgactc agagatttcc acactcagag 21420 atgaccactc tcatgagcag aggtcctgga gatatgtcat ggcaaagctc tccctctctg 21480 gaaaatccca gctctctccc ttccctgctg tctttacctg ccacaacctc acctcctccc 21540 atttcctcca cattaccagt gactatctcc tcctctcctc ttcctgtgac ttcacttctc 21600 acctctagcc cggtaacgac cacagacatg ttacacacaa gcccagaact tgtaaccagt 21660 tcacctccaa agctgagcca cacttcagat gagagactga ccactggcaa ggacaccaca 21720 aatacagaag ctgtgcatcc ttccacaaac acagcagcgt ccaatgtgga gattcccagc 21780 tttggacatg aatccccttc ctctgcctta gctgactcag agacatccaa agccacatca 21840 ccaatgttta ttacctccac ccaggaggat acaactgttg ccatatcaac ccctcacttc 21900 ttggagacta gcagaattca gaaagagtca atttcctccc tgagccctaa attgagggag 21960 acaggcagtt ctgtggagac aagctcagcc atagagacaa gtgctgtcct ttctgaagtg 22020 tccattggtg ctactactga gatctccagg acagaagtca cctcctctag cagaacatcc 22080 atctctggtt ctgctgagtc cacaatgttg ccagaaatat ccaccacaag aaaaatcatt 22140 aagttcccta cttcccccat cctggcagaa tcatcagaaa tgaccatcaa gacccaaaca 22200 agtcctcctg ggtctacatc agagagtacc tttacattag acacatcaac cactccctcc 22260 ttggtaataa cccattcgac tatgactcag agattgccac actcagagat aaccactctt 22320 gtgagtagag gtgctgggga tgtgccacgg cccagctctc tccctgtgga agaaacaagc 22380 cctccatctt cccagctgtc tttatctgcc atgatctcac cttctcctgt ttcttccaca 22440 ttaccagcaa gtagccactc ctcttctgct tctgtgactt cacctctcac accaggccaa 22500 gtgaagacta ctgaggtgtt ggacgcaagt gcagaacctg aaaccagttc acctccaagt 22560 ttgagcagca cctcagttga aatactggcc acctctgaag tcaccacaga tacggagaaa 22620 attcatcctt tcccaaacac ggcagtaacc aaagttggaa cttccagttc tggacatgaa 22680 tccccttcct ctgtcctacc tgactcagag acaaccaaag ccacatcggc aatgggtacc 22740 atctccatta tgggggatac aagtgtttct acattaactc ctgccttatc taacactagg 22800 aaaattcagt cagagccagc ttcctcactg accaccagat tgagggagac cagcacctct 22860 gaagagacca gcttagccac agaagcaaac actgttcttt ctaaagtgtc cactggtgct 22920 actactgagg tctccaggac agaagccatc tcctttagca gaacatccat gtcaggccct 22980 gagcagtcca caatgtcaca agacatctcc ataggaacca tccccaggat ttctgcctcc 23040 tctgtcctga cagaatctgc aaaaatgacc atcacaaccc aaacaggtcc ttcggagtct 23100 acactagaaa gtacccttaa tttgaacaca gcaaccacac cctcttgggt ggaaacccac 23160 tctatagtaa ttcagggatt tccacaccca gagatgacca cttccatggg cagaggtcct 23220 ggaggtgtgt catggcctag ccctcccttt gtgaaagaaa ccagccctcc atcctccccg 23280 ctgtctttac ctgccgtgac ctcacctcat cctgtttcca ccacattcct agcacatatc 23340 cccccctctc cccttcctgt gacttcactt ctcacctctg gcccggcgac aaccacagat 23400 atcttgggta caagcacaga acctggaacc agttcatctt caagtttgag caccacctcc 23460 catgagagac tgaccactta caaagacact gcacatacag aagccgtgca tccttccaca 23520 aacacaggag ggaccaatgt ggcaaccacc agctctggat ataaatcaca gtcctctgtc 23580 ctagctgact catctccaat gtgtaccacc tccaccatgg gggatacaag tgttctcaca 23640 tcaactcctg ccttccttga gactaggagg attcagacag agctagcttc ctccctgacc 23700 cctggattga gggagtccag tggctctgaa gggaccagct caggcaccaa gatgagcact 23760 gtcctctcta aagtgcccac tggtgctact actgagatct ccaaggaaga cgtcacctcc 23820 atcccaggtc ccgctcaatc cacaatatca ccagacatct ccacaagaac cgtcagctgg 23880 ttctctacat cccctgtcat gacagaatca gcagaaataa ccatgaacac ccatacaagt 23940 cctttagggg ccacaacaca aggcaccagt actttggcca cgtcaagcac aacctctttg 24000 acaatgacac actcaactat atctcaagga ttttcacact cacagatgag cactcttatg 24060 aggaggggtc ctgaggatgt atcatggatg agccctcccc ttctggaaaa aactagacct 24120 tccttttctc tgatgtcttc accagccaca acttcacctt ctcctgtttc ctccacatta 24180 ccagagagca tctcttcctc tcctcttcct gtgacttcac tcctcacgtc tggcttggca 24240 aaaactacag atatgttgca caaaagctca gaacctgtaa ccaactcacc tgcaaatttg 24300 agcagcacct cagttgaaat actggccacc tctgaagtca ccacagatac agagaaaact 24360 catccttctt caaacagaac agtgaccgat gtggggacct ccagttctgg acatgaatcc 24420 acttcctttg tcctagctga ctcacagaca tccaaagtca catctccaat ggttattacc 24480 tccaccatgg aggatacgag tgtctccaca tcaactcctg gcttttttga gactagcaga 24540 attcagacag aaccaacatc ctccctgacc cttggactga gaaagaccag cagctctgag 24600 gggaccagct tagccacaga gatgagcact gtcctttctg gagtgcccac tggtgccact 24660 gctgaagtct ccaggacaga agtcacctcc tctagcagaa catccatctc aggctttgct 24720 cagctcacag tgtcaccaga gacttccaca gaaaccatca ccagactccc tacctccagc 24780 ataatgacag aatcagcaga aatgatgatc aagacacaaa cagatcctcc tgggtctaca 24840 ccagagagta ctcatactgt ggacatatca acaacaccca actgggtaga aacccactcg 24900 actgtgactc agagattttc acactcagag atgaccactc ttgtgagcag aagccctggt 24960 gatatgttat ggcctagtca atcctctgtg gaagaaacca gctctgcctc ttccctgctg 25020 tctctgcctg ccacgacctc accttctcct gtttcctcta cattagtaga ggatttccct 25080 tccgcttctc ttcctgtgac ttctcttctc acccctggcc tggtgataac cacagacagg 25140 atgggcataa gcagagaacc tggaaccagt tccacttcaa atttgagcag cacctcccat 25200 gagagactga ccactttgga agacactgta gatacagaag acatgcagcc ttccacacac 25260 acagcagtga ccaacgtgag gacctccatt tctggacatg aatcacaatc ttctgtccta 25320 tctgactcag agacacccaa agccacatct ccaatgggta ccacctacac catgggggaa 25380 acgagtgttt ccatatccac ttctgacttc tttgagacca gcagaattca gatagaacca 25440 acatcctccc tgacttctgg attgagggag accagcagct ctgagaggat cagctcagcc 25500 acagagggaa gcactgtcct ttctgaagtg cccagtggtg ctaccactga ggtctccagg 25560 acagaagtga tatcctctag gggaacatcc atgtcagggc ctgatcagtt caccatatca 25620 ccagacatct ctactgaagc gatcaccagg ctttctactt cccccattat gacagaatca 25680 gcagaaagtg ccatcactat tgagacaggt tctcctgggg ctacatcaga gggtaccctc 25740 accttggaca cctcaacaac aaccttttgg tcagggaccc actcaactgc atctccagga 25800 ttttcacact cagagatgac cactcttatg agtagaactc ctggagatgt gccatggccg 25860 agccttccct ctgtggaaga agccagctct gtctcttcct cactgtcttc acctgccatg 25920 acctcaactt cttttttctc cgcattacca gagagcatct cctcctctcc tcatcctgtg 25980 actgcacttc tcacccttgg cccagtgaag accacagaca tgttgcgcac aagctcagaa 26040 cctgaaacca gttcacctcc aaatttgagc agcacctcag ctgaaatatt agccacgtct 26100 gaagtcacca aagatagaga gaaaattcat ccctcctcaa acacacctgt agtcaatgta 26160 gggactgtga tttataaaca tctatcccct tcctctgttt tggctgactt agtgacaaca 26220 aaacccacat ctccaatggc taccacctcc actctgggga atacaagtgt ttccacatca 26280 actcctgcct tcccagaaac tatgatgaca cagccaactt cctccctgac ttctggatta 26340 agggagatca gtacctctca agagaccagc tcagcaacag agagaagtgc ttctctttct 26400 ggaatgccca ctggtgctac tactaaggtc tccagaacag aagccctctc cttaggcaga 26460 acatccaccc caggtcctgc tcaatccaca atatcaccag aaatctccac ggaaaccatc 26520 actagaattt ctactcccct caccacgaca ggatcagcag aaatgaccat cacccccaaa 26580 acaggtcatt ctggggcatc ctcacaaggt acctttacct tggacacatc aagcagagcc 26640 tcctggccag gaactcactc agctgcaact cacagatctc cacactcagg gatgaccact 26700 cctatgagca gaggtcctga ggatgtgtca tggccaagcc gcccatcagt ggaaaaaact 26760 agccctccat cttccctggt gtctttatct gcagtaacct caccttcgcc actttattcc 26820 acaccatctg agagtagcca ctcatctcct ctccgggtga cttctctttt cacccctgtc 26880 atgatgaaga ccacagacat gttggacaca agcttggaac ctgtgaccac ttcacctccc 26940 agtatgaata tcacctcaga tgagagtctg gccacttcta aagccaccat ggagacagag 27000 gcaattcagc tttcagaaaa cacagctgtg actcagatgg gcaccatcag cgctagacaa 27060 gaattctatt cctcttatcc aggcctccca gagccatcca aagtgacatc tccagtggtc 27120 acctcttcca ccataaaaga cattgtttct acaaccatac ctgcttcctc tgagataaca 27180 agaattgaga tggagtcaac atccaccctg acccccacac caagggagac cagcacctcc 27240 caggagatcc actcagccac aaagccaagc actgttcctt acaaggcact cactagtgcc 27300 acgattgagg actccatgac acaagtcatg tcctctagca gaggacctag ccctgatcag 27360 tccacaatgt cacaagacat atccagtgaa gtgatcacca ggctctctac ctcccccatc 27420 aaggcagaat ctacagaaat gaccattacc acccaaacag gttctcctgg ggctacatca 27480 aggggtaccc ttaccttgga cacttcaaca acttttatgt cagggaccca ctcaactgca 27540 tctcaaggat tttcacactc acagatgacc gctcttatga gtagaactcc tggagatgtg 27600 ccatggctaa gccatccctc tgtggaagaa gccagctctg cctctttctc actgtcttca 27660 cctgtcatga cctcatcttc tcccgtttct tccacattac cagacagcat ccactcttct 27720 tcgcttcctg tgacatcact tctcacctca gggctggtga agaccacaga gctgttgggc 27780 acaagctcag aacctgaaac cagttcaccc ccaaatttga gcagcacctc agctgaaata 27840 ctggccacca ctgaagtcac tacagataca gagaaactgg agatgaccaa tgtggtaacc 27900 tcaggttata cacatgaatc tccttcctct gtcctagctg actcagtgac aacaaaggcc 27960 acatcttcaa tgggtatcac ctaccccaca ggagatacaa atgttctcac atcaacccct 28020 gccttctctg acaccagtag gattcaaaca aagtcaaagc tctcactgac tcctgggttg 28080 atggagacca gcatctctga agagaccagc tctgccacag aaaaaagcac tgtcctttct 28140 agtgtgccca ctggtgctac tactgaggtc tccaggacag aagccatctc ttctagcaga 28200 acatccatcc caggccctgc tcaatccaca atgtcatcag acacctccat ggaaaccatc 28260 actagaattt ctacccccct cacaaggaaa gaatcaacag acatggccat cacccccaaa 28320 acaggtcctt ctggggctac ctcgcagggt acctttacct tggactcatc aagcacagcc 28380 tcctggccag gaactcactc agctacaact cagagatttc cacagtcagt ggtgacaact 28440 cctatgagca gaggtcctga ggatgtgtca tggccaagcc cgctgtctgt ggaaaaaaac 28500 agccctccat cttccctggt atcttcatct tcagtaacct caccttcgcc actttattcc 28560 acaccatctg ggagtagcca ctcctctcct gtccctgtca cttctctttt cacctctatc 28620 atgatgaagg ccacagacat gttggatgca agtttggaac ctgagaccac ttcagctccc 28680 aatatgaata tcacctcaga tgagagtctg gccacttcta aagccaccac ggagacagag 28740 gcaattcacg tttttgaaaa tacagcagcg tcccatgtgg aaaccaccag tgctacagag 28800 gaactctatt cctcttcccc aggcttctca gagccaacaa aagtgatatc tccagtggtc 28860 acctcttcct ctataagaga caacatggtt tccacaacaa tgcctggctc ctctggcatt 28920 acaaggattg agatagagtc aatgtcatct ctgacccctg gactgaggga gaccagaacc 28980 tcccaggaca tcacctcatc cacagagaca agcactgtcc tttacaagat gtcctctggt 29040 gccactcctg aggtctccag gacagaagtt atgccctcta gcagaacatc cattcctggc 29100 cctgctcagt ccacaatgtc actagacatc tccgatgaag ttgtcaccag gctgtctacc 29160 tctcccatca tgacagaatc tgcagaaata accatcacca cccaaacagg ttattctctg 29220 gctacatccc aggttaccct tcccttgggc acctcaatga cctttttgtc agggacccac 29280 tcaactatgt ctcaaggact ttcacactca gagatgacca atcttatgag caggggtcct 29340 gaaagtctgt catggacgag ccctcgcttt gtggaaacaa ctagatcttc ctcttctctg 29400 acatcattac ctctcacgac ctcactttct cctgtgtcct ccacattact agacagtagc 29460 ccctcctctc ctcttcctgt gacttcactt atcctcccag gcctggtgaa gactacagaa 29520 gtgttggata caagctcaga gcctaaaacc agttcatctc caaatttgag cagcacctca 29580 gttgaaatac cggccacctc tgaaatcatg acagatacag agaaaattca tccttcctca 29640 aacacagcgg tggccaaagt gaggacctcc agttctgttc atgaatctca ttcctctgtc 29700 ctagctgact cagaaacaac cataaccata ccttcaatgg gtatcacctc cgctgtggac 29760 gataccactg ttttcacatc aaatcctgcc ttctctgaga ctaggaggat tccgacagag 29820 ccaacattct cattgactcc tggattcagg gagactagca cctctgaaga gaccacctca 29880 atcacagaaa caagtgcagt cctttatgga gtgcccacta gtgctactac tgaagtctcc 29940 atgacagaaa tcatgtcctc taatagaaca cacatccctg actctgatca gtccacgatg 30000 tctccagaca tcatcactga agtgatcacc aggctctctt cctcatccat gatgtcagaa 30060 tcaacacaaa tgaccatcac cacccaaaaa agttctcctg gggctacagc acagagtact 30120 cttaccttgg ccacaacaac agcccccttg gcaaggaccc actcaactgt tcctcctaga 30180 tttttacact cagagatgac aactcttatg agtaggagtc ctgaaaatcc atcatggaag 30240 agctctccct ttgtggaaaa aactagctct tcatcttctc tgttgtcctt acctgtcacg 30300 acctcacctt ctgtttcttc cacattaccg cagagtatcc cttcctcctc tttttctgtg 30360 acttcactcc tcaccccagg catggtgaag actacagaca caagcacaga acctggaacc 30420 agtttatctc caaatctgag tggcacctca gttgaaatac tggctgcctc tgaagtcacc 30480 acagatacag agaaaattca tccttcttca agcatggcag tgaccaatgt gggaaccacc 30540 agttctggac atgaactata ttcctctgtt tcaatccact cggagccatc caaggctaca 30600 tacccagtgg gtactccctc ttccatggct gaaacctcta tttccacatc aatgcctgct 30660 aattttgaga ccacaggatt tgaggctgag ccattttctc atttgacttc tggatttagg 30720 aagacaaaca tgtccctgga caccagctca gtcacaccaa caaatacacc ttcttctcct 30780 gggtccactc accttttaca gagttccaag actgatttca cctcttctgc aaaaacatca 30840 tccccagact ggcctccagc ctcacagtat actgaaattc cagtggacat aatcaccccc 30900 tttaatgctt ctccatctat tacggagtcc actgggataa cctccttccc agaatccagg 30960 tttactatgt ctgtaacaga aagtactcat catctgagta cagatttgct gccttcagct 31020 gagactattt ccactggcac agtgatgcct tctctatcag aggccatgac ttcatttgcc 31080 accactggag ttccacgagc catctcaggt tcaggtagtc cattctctag gacagagtca 31140 ggccctgggg atgctactct gtccaccatt gcagagagcc tgccttcatc cactcctgtg 31200 ccattctcct cttcaacctt cactaccact gattcttcaa ccatcccagc cctccatgag 31260 ataacttcct cttcagctac cccatataga gtggacacca gtcttgggac agagagcagc 31320 actactgaag gacgcttggt tatggtcagt actttggaca cttcaagcca accaggcagg 31380 acatcttcaa cacccatttt ggataccaga atgacagaga gcgttgagct gggaacagtg 31440 acaagtgctt atcaagttcc ttcactctca acacggttga caagaactga tggcattatg 31500 gaacacatca caaaaatacc caatgaagca gcacacagag gtaccataag accagtcaaa 31560 ggccctcaga catccacttc gcctgccagt cctaaaggac tacacacagg agggacaaaa 31620 agaatggaga ccaccaccac agctttgaag accaccacca cagctttgaa gaccacttcc 31680 agagccacct tgaccaccag tgtctatact cccactttgg gaacactgac tcccctcaat 31740 gcatcaaggc aaatggccag cacaatcctc acagaaatga tgatcacaac cccatatgtt 31800 ttccctgatg ttccagaaac gacatcctca ttggctacca gcctgggagc agaaaccagc 31860 acagctcttc ccaggacaac cccatctgtt ctcaatagag aatcagagac cacagcctca 31920 ctggtctctc gttctggggc agagagaagt ccggttattc aaactctaga tgtttcttct 31980 agtgagccag atacaacagc ttcatgggtt atccatcctg cagagaccat cccaactgtt 32040 tccaagacaa cccccaattt tttccacagt gaattagaca ctgtatcttc cacagccacc 32100 agtcatgggg cagacgtcag ctcagccatt ccaacaaata tctcacctag tgaactagat 32160 gcactgaccc cactggtcac tatttcgggg acagatacta gtacaacatt cccaacactg 32220 actaagtccc cacatgaaac agagacaaga accacatggc tcactcatcc tgcagagacc 32280 agctcaacta ttcccagaac aatccccaat ttttctcatc atgaatcaga tgccacacct 32340 tcaatagcca ccagtcctgg ggcagaaacc agttcagcta ttccaattat gactgtctca 32400 cctggtgcag aagatctggt gacctcacag gtcactagtt ctgggacaga cagaaatatg 32460 actattccaa ctttgactct ttctcctggt gaaccaaaga cgatagcctc attagtcacc 32520 catcctgaag cacagacaag ttcggccatt ccaacttcaa ctatctcgcc tgctgtatca 32580 cggttggtga cctcaatggt caccagtttg gcggcaaaga caagtacaac taatcgagct 32640 ctgacaaact cccctggtga accagctaca acagtttcat tggtcacgca tcctgcacag 32700 accagcccaa cagttccctg gacaacttcc atttttttcc atagtaaatc agacaccaca 32760 ccttcaatga ccaccagtca tggggcagaa tccagttcag ctgttccaac tccaactgtt 32820 tcaactgagg taccaggagt agtgacccct ttggtcacca gttctagggc agtgatcagt 32880 acaactattc caattctgac tctttctcct ggtgaaccag agaccacacc ttcaatggcc 32940 accagtcatg gggaagaagc cagttctgct attccaactc caactgtttc acctggggta 33000 ccaggagtgg tgacctctct ggtcactagt tctagggcag tgactagtac aactattcca 33060 attctgactt tttctcttgg tgaaccagag accacacctt caatggccac cagtcatggg 33120 acagaagctg gctcagctgt tccaactgtt ttacctgagg taccaggaat ggtgacctct 33180 ctggttgcta gttctagggc agtaaccagt acaactcttc caactctgac tctttctcct 33240 ggtgaaccag agaccacacc ttcaatggcc accagtcatg gggcagaagc cagctcaact 33300 gttccaactg tttcacctga ggtaccagga gtggtgacct ctctggtcac tagttctagt 33360 ggagtaaaca gtacaagtat tccaactctg attctttctc ctggtgaact agaaaccaca 33420 ccttcaatgg ccaccagtca tggggcagaa gccagctcag ctgttccaac tccaactgtt 33480 tcacctgggg tatcaggagt ggtgacccct ctggtcacta gttccagggc agtgaccagt 33540 acaactattc caattctaac tctttcttct agtgagccag agaccacacc ttcaatggcc 33600 accagtcatg gggtagaagc cagctcagct gttctaactg tttcacctga ggtaccagga 33660 atggtgacct ctctggtcac tagttctaga gcagtaacca gtacaactat tccaactctg 33720 actatttctt ctgatgaacc agagaccaca acttcattgg tcacccattc tgaggcaaag 33780 atgatttcag ccattccaac tttagctgtc tcccctactg tacaagggct ggtgacttca 33840 ctggtcacta gttctgggtc agagaccagt gcgttttcaa atctaactgt tgcctcaagt 33900 caaccagaga ccatagactc atgggtcgct catcctggga cagaagcaag ttctgttgtt 33960 ccaactttga ctgtctccac tggtgagccg tttacaaata tctcattggt cacccatcct 34020 gcagagagta gctcaactct tcccaggaca acctcaaggt tttcccacag tgaattagac 34080 actatgcctt ctacagtcac cagtcctgag gcagaatcca gctcagccat ttcaactact 34140 atttcacctg gtataccagg tgtgctgaca tcactggtca ctagctctgg gagagacatc 34200 agtgcaactt ttccaacagt gcctgagtcc ccacatgaat cagaggcaac agcctcatgg 34260 gttactcatc ctgcagtcac cagcacaaca gttcccagga caacccctaa ttattctcat 34320 agtgaaccag acaccacacc atcaatagcc accagtcctg gggcagaagc cacttcagat 34380 tttccaacaa taactgtctc acctgatgta ccagatatgg taacctcaca ggtcactagt 34440 tctgggacag acaccagtat aactattcca actctgactc tttcttctgg tgagccagag 34500 accacaacct catttatcac ctattctgag acacacacaa gttcagccat tccaactctc 34560 cctgtctccc ctggtgcatc aaagatgctg acctcactgg tcatcagttc tgggacagac 34620 agcactacaa ctttcccaac actgacggag accccatatg aaccagagac aacagccata 34680 cagctcattc atcctgcaga gaccaacaca atggttccca agacaactcc caagttttcc 34740 catagtaagt cagacaccac actcccagta gccatcacca gtcctgggcc agaagccagt 34800 tcagctgttt caacgacaac tatctcacct gatatgtcag atctggtgac ctcactggtc 34860 cctagttctg ggacagacac cagtacaacc ttcccaacat tgagtgagac cccatatgaa 34920 ccagagacta cagtcacgtg gctcactcat cctgcagaaa ccagcacaac ggtttctggg 34980 acaattccca acttttccca taggggatca gacactgcac cctcaatggt caccagtcct 35040 ggagtagaca cgaggtcagg tgttccaact acaaccatcc cacccagtat accaggggta 35100 gtgacctcac aggtcactag ttctgcaaca gacactagta cagctattcc aactttgact 35160 ccttctcctg gtgaaccaga gaccacagcc tcatcagcta cccatcctgg gacacagact 35220 ggcttcactg ttccaattcg gactgttccc tctagtgagc cagatacaat ggcttcctgg 35280 gtcactcatc ctccacagac cagcacacct gtttccagaa caacctccag tttttcccat 35340 agtagtccag atgccacacc tgtaatggcc accagtccta ggacagaagc cagttcagct 35400 gtactgacaa caatctcacc tggtgcacca gagatggtga cttcacagat cactagttct 35460 ggggcagcaa ccagtacaac tgttccaact ttgactcatt ctcctggtat gccagagacc 35520 acagccttat tgagcaccca tcccagaaca gggacaagta aaacatttcc tgcttcaact 35580 gtgtttcctc aagtatcaga gaccacagcc tcactcacca ttagacctgg tgcagagact 35640 agcacagctc tcccaactca gacaacatcc tctctcttca ccctacttgt aactggaacc 35700 agcagagttg atctaagtcc aactgcttca cctggtgttt ctgcaaaaac agccccactt 35760 tccacccatc cagggacaga gaccagcaca atgattccaa cttcaactct ttcccttggt 35820 ttactagaga ctacaggctt actggccacc agctcttcag cagagaccag cacgagtact 35880 ctaactctga ctgtttcccc tgctgtctct gggctttcca gtgcctctat aacaactgat 35940 aagccccaaa ctgtgacctc ctggaacaca gaaacctcac catctgtaac ttcagttgga 36000 cccccagaat tttccaggac tgtcacaggc accactatga ccttgatacc atcagagatg 36060 ccaacaccac ctaaaaccag tcatggagaa ggagtgagtc caaccactat cttgagaact 36120 acaatggttg aagccactaa tttagctacc acaggttcca gtcccactgt ggccaagaca 36180 acaaccacct tcaatacact ggctggaagc ctctttactc ctctgaccac acctgggatg 36240 tccaccttgg cctctgagag tgtgacctca agaacaagtt ataaccatcg gtcctggatc 36300 tccaccacca gcagttataa ccgtcggtac tggacccctg ccaccagcac tccagtgact 36360 tctacattct ccccagggat ttccacatcc tccatcccca gctccacagc agccacagtc 36420 ccattcatgg tgccattcac cctcaacttc accatcacca acctgcagta cgaggaggac 36480 atgcggcacc ctggttccag gaagttcaac gccacagaga gagaactgca gggtctgctc 36540 aaacccttgt tcaggaatag cagtctggaa tacctctatt caggctgcag actagcctca 36600 ctcaggccag agaaggatag ctcagccatg gcagtggatg ccatctgcac acatcgccct 36660 gaccctgaag acctcggact ggacagagag cgactgtact gggagctgag caatctgaca 36720 aatggcatcc aggagctggg cccctacacc ctggaccgga acagtctcta tgtcaatggt 36780 ttcacccatc gaagctctat gcccaccacc agcactcctg ggacctccac agtggatgtg 36840 ggaacctcag ggactccatc ctccagcccc agccccacgg ctgctggccc tctcctgatg 36900 ccgttcaccc tcaacttcac catcaccaac ctgcagtacg aggaggacat gcgtcgcact 36960 ggctccagga agttcaacac catggagagt gtcctgcagg gtctgctcaa gcccttgttc 37020 aagaacacca gtgttggccc tctgtactct ggctgcagat tgaccttgct caggcccgag 37080 aaagatgggg cagccactgg agtggatgcc atctgcaccc accgccttga ccccaaaagc 37140 cctggactca acagggagca gctgtactgg gagctaagca aactgaccaa tgacattgaa 37200 gagctgggcc cctacaccct ggacaggaac agtctctatg tcaatggttt cacccatcag 37260 agctctgtgt ccaccaccag cactcctggg acctccacag tggatctcag aacctcaggg 37320 actccatcct ccctctccag ccccacaatt atggctgctg gccctctcct ggtaccattc 37380 accctcaact tcaccatcac caacctgcag tatggggagg acatgggtca ccctggctcc 37440 aggaagttca acaccacaga gagggtcctg cagggtctgc ttggtcccat attcaagaac 37500 accagtgttg gccctctgta ctctggctgc agactgacct ctctcaggtc tgagaaggat 37560 ggagcagcca ctggagtgga tgccatctgc atccatcatc ttgaccccaa aagccctgga 37620 ctcaacagag agcggctgta ctgggagctg agccaactga ccaatggcat caaagagctg 37680 ggcccctaca ccctggacag gaacagtctc tatgtcaatg gtttcaccca tcggacctct 37740 gtgcccacca ccagcactcc tgggacctcc acagtggacc ttggaacctc agggactcca 37800 ttctccctcc caagccccgc aactgctggc cctctcctgg tgctgttcac cctcaacttc 37860 accatcacca acctgaagta tgaggaggac atgcatcgcc ctggctccag gaagttcaac 37920 accactgaga gggtcctgca gactctgctt ggtcctatgt tcaagaacac cagtgttggc 37980 cttctgtact ctggctgcag actgaccttg ctcaggtccg agaaggatgg agcagccact 38040 ggagtggatg ccatctgcac ccaccgtctt gaccccaaaa gccctggact ggacagagag 38100 cagctatact gggagctgag ccagctgacc aatggcatca aagagctggg cccctacacc 38160 ctggacagga acagtctcta tgtcaatggt ttcacccatt ggatccctgt gcccaccagc 38220 agcactcctg ggacctccac agtggacctt gggtcaggga ctccatcctc cctccccagc 38280 cccacagctg ctggccctct cctggtgcca ttcaccctca acttcaccat caccaacctg 38340 cagtacgagg aggacatgca tcacccaggc tccaggaagt tcaacaccac ggagcgggtc 38400 ctgcagggtc tgcttggtcc catgttcaag aacaccagtg tcggccttct gtactctggc 38460 tgcagactga ccttgctcag gtccgagaag gatggagcag ccactggagt ggatgccatc 38520 tgcacccacc gtcttgaccc caaaagccct ggagtggaca gggagcagct atactgggag 38580 ctgagccagc tgaccaatgg catcaaagag ctgggtccct acaccctgga cagaaacagt 38640 ctctatgtca atggtttcac ccatcagacc tctgcgccca acaccagcac tcctgggacc 38700 tccacagtgg accttgggac ctcagggact ccatcctccc tccccagccc tacatcngct 38760 ggccctctcc tggtnccntt caccctcaac ttcaccatca ccaacctgca gtacgaggag 38820 gacatgcggc acccnggntc caggaagttc aacaccacng agagggtnct gcagggtctg 38880 ctnaagcccc tnttcaagag caccagtgtt ggccctctgt actctggctg cagactgacc 38940 ttgctcaggt ccgagaagga tggagcagcc actggagtgg atgccatctg cacccaccgt 39000 cttgacccca aaagccctgg agtggacagg gagcagctat actgggagct gagccagctg 39060 accaatggca tcaaagagct gggtccctac accctggaca gaaacagtct ctatgtcaat 39120 ggtttcaccc atcagacctc tgcgcccaac accagcactc ctgggacctc cacagtggac 39180 cttgggacct cagggactcc atcctccctc cccagcccta catctgctgg ccctctcctg 39240 gtgccattca ccctcaactt caccatcacc aacctgcagt acgaggagga catgcatcac 39300 ccaggctcca ggaagttcaa caccacggag cgggtcctgc agggtctgct tggtcccatg 39360 ttcaagaaca ccagtgtcgg ccttctgtac tctggctgca gactgacctt gctcaggcct 39420 gagaagaatg gggcagccac tggaatggat gccatctgca gccaccgtct tgaccccaaa 39480 agccctggac tcaacagaga gcagctgtac tgggagctga gccagctgac ccatggcatc 39540 aaagagctgg gcccctacac cctggacagg aacagtctct atgtcaatgg tttcacccat 39600 cggagctctg tggcccccac cagcactcct gggacctcca cagtggacct tgggacctca 39660 gggactccat cctccctccc cagccccaca acagctgttc ctctcctggt gccgttcacc 39720 ctcaacttta ccatcaccaa tctgcagtat ggggaggaca tgcgtcaccc tggctccagg 39780 aagttcaaca ccacagagag ggtcctgcag ggtctgcttg gtcccttgtt caagaactcc 39840 agtgtcggcc ctctgtactc tggctgcaga ctgatctctc tcaggtctga gaaggatggg 39900 gcagccactg gagtggatgc catctgcacc caccacctta accctcaaag ccctggactg 39960 gacagggagc agctgtactg gcagctgagc cagatgacca atggcatcaa agagctgggc 40020 ccctacaccc tggaccggaa cagtctctac gtcaatggtt tcacccatcg gagctctggg 40080 ctcaccacca gcactccttg gacttccaca gttgaccttg gaacctcagg gactccatcc 40140 cccgtcccca gccccacaac tgctggccct ctcctggtgc cattcaccct caacttcacc 40200 atcaccaacc tgcagtatga ggaggacatg catcgccctg gatctaggaa gttcaacacc 40260 acagagaggg tcctgcaggg tctgcttagt cccattttca agaactccag tgttggccct 40320 ctgtactctg gctgcagact gacctctctc aggcccgaga aggatggggc agcaactgga 40380 atggatgctg tctgcctcta ccaccctaat cccaaaagac ctggactgga cagagagcag 40440 ctgtactggg agctaagcca gctgacccac aacatcactg agctgggccc ctacagcctg 40500 gacagggaca gtctctatgt caatggtttc acccatcaga actctgtgcc caccaccagt 40560 actcctggga cctccacagt gtactgggca accactggga ctccatcctc cttccccggc 40620 cacacagagc ctggccctct cctgatacca ttcactttca actttaccat caccaacctg 40680 cattatgagg aaaacatgca acaccctggt tccaggaagt tcaacaccac ggagagggtt 40740 ctgcagggtc tgctcaagcc cttgttcaag aacaccagtg ttggccctct gtactctggc 40800 tgcagactga cctctctcag gcccgagaag gatggggcag caactggaat ggatgctgtc 40860 tgcctctacc accctaatcc caaaagacct gggctggaca gagagcagct gtactgggag 40920 ctaagccagc tgacccacaa catcactgag ctgggcccct acagcctgga cagggacagt 40980 ctctatgtca atggtttcac ccatcagaac tctgtgccca ccaccagtac tcctgggacc 41040 tccacagtgt actgggcaac cactgggact ccatcctcct tccccggcca cacagagcct 41100 ggccctctcc tgataccatt cactttcaac tttaccatca ccaacctgca ttatgaggaa 41160 aacatgcaac accctggttc caggaagttc aacaccacgg agagggttct gcagggtctg 41220 ctcaagccct tgttcaagaa caccagtgtt ggccctctgt actctggctg cagactgacc 41280 ttgctcagac ctgagaagca tgaggcagcc actggagtgg acaccatctg tacccaccgc 41340 gttgatccca tcggacctgg actggacagg gagcggctat actgggagct gagccagctg 41400 accaacagca ttaccgaact gggaccctac accctggaca gggacagtct ctatgtcaat 41460 ggcttcaacc ctcggagctc tgtgccaacc accagcactc ctgggacctc cacagtgcac 41520 ctggcaacct ctgggactcc atcctccctg cctggccaca cagcccctgt ccctctcttg 41580 ataccattca ccctcaactt taccatcacc aacctgcatt atgaggaaaa catgcaacac 41640 cctggttcca ggaagttcaa caccacggag agggttctgc agggtctgct caagcccttg 41700 ttcaagaaca ccagtgttgg ccctctgtac tctggctgca gactgacctt gctcagacct 41760 gagaagcatg aggcagccac tggagtggac accatctgta cccaccgcgt tgatcccatc 41820 ggacctggac tgnacagnga gcngctntac tgggagctna gccanctgac caannncatc 41880 nnngagctgg gnccctacac cctggacagg nacagtctct atgtcaatgg tttcacccat 41940 cnganctctg ngcccaccac cagcactcct gggacctcca cagtgnacnt nggnacctcn 42000 gggactccat cctccntccc cngccncaca tctgctggcc ctctcctggt gccattcacc 42060 ctcaacttca ccatcaccaa cctgcagtac gaggaggaca tgcatcaccc aggctccagg 42120 aagttcaaca ccacggagcg ggtcctgcag ggtctgcttg gtcccatgtt caagaacacc 42180 agtgtcggcc ttctgtactc tggctgcaga ctgaccttgc tcaggcctga gaagaatggg 42240 gcagccactg gaatggatgc catctgcagc caccgtcttg accccaaaag ccctggactc 42300 gacagagagc agctgtactg ggagctgagc cagctgaccc atggcatcaa agagctgggc 42360 ccctacaccc tggacaggaa cagtctctat gtcaatggtt tcacccatcg gagctctgtg 42420 gcccccacca gcactcctgg gacctccaca gtggaccttg ggacctcagg gactccatcc 42480 tccctcccca gccccacaac agctgttcct ctcctggtgc cgttcaccct caactttacc 42540 atcaccaatc tgcagtatgg ggaggacatg cgtcaccctg gctccaggaa gttcaacacc 42600 acagagaggg tcctgcaggg tctgcttggt cccttgttca agaactccag tgtcggccct 42660 ctgtactctg gctgcagact gatctctctc aggtctgaga aggatggggc agccactgga 42720 gtggatgcca tctgcaccca ccaccttaac cctcaaagcc ctggactgga cagggagcag 42780 ctgtactggc agctgagcca gatgaccaat ggcatcaaag agctgggccc ctacaccctg 42840 gaccggaaca gtctctacgt caatggtttc acccatcgga gctctgggct caccaccagc 42900 actccttgga cttccacagt tgaccttgga acctcaggga ctccatcccc cgtccccagc 42960 cccacaactg ctggccctct cctggtgcca ttcaccctaa acttcaccat caccaacctg 43020 cagtatgagg aggacatgca tcgccctgga tctaggaagt tcaacgccac agagagggtc 43080 ctgcagggtc tgcttagtcc catattcaag aactccagtg ttggccctct gtactctggc 43140 tgcagactga cctctctcag gcccgagaag gatggggcag caactggaat ggatgctgtc 43200 tgcctctacc accctaatcc caaaagacct ggactggaca gagagcagct gtactgggag 43260 ctaagccagc tgacccacaa catcactgag ctgggcccct acagcctgga cagggacagt 43320 ctctatgtca atggtttcac ccatcagagc tctatgacga ccaccagaac tcctgatacc 43380 tccacaatgc acctggcaac ctcgagaact ccagcctccc tgtctggacc tacgaccgcc 43440 agccctctcc tggtgctatt cacaatcaac tgcaccatca ccaacctgca gtacgaggag 43500 gacatgcgtc gcactggctc caggaagttc aacaccatgg agagtgtcct gcagggtctg 43560 ctcaagccct tgttcaagaa caccagtgtt ggccctctgt actctggctg cagattgacc 43620 ttgctcaggc ccaagaaaga tggggcagcc actggagtgg atgccatctg cacccaccgc 43680 cttgacccca aaagccctgg actcaacagg gagcagctgt actgggagct aagcaaactg 43740 accaatgaca ttgaagagct gggcccctac accctggaca ggaacagtct ctatgtcaat 43800 ggtttcaccc atcagagctc tgtgtccacc accagcactc ctgggacctc cacagtggat 43860 ctcagaacct cagggactcc atcctccctc tccagcccca caattatgnc nnctgnccct 43920 ctcctgntnc cnttcaccnt caacttnacc atcaccaacc tgcantangn ggannacatg 43980 cnncncccng gntccaggaa gttcaacacc acngagaggg tcctacaggg tctgctcagg 44040 cccttgttca agaacaccag tgtcagctct ctgtactctg gttgcagact gaccttgctc 44100 aggcctgaga aggatggggc agccaccaga gtggatgctg cctgcaccta ccgccctgat 44160 cccaaaagcc ctggactgga cagagagcaa ctatactggg agctgagcca gctaacccac 44220 agcatcactg agctgggacc ctacaccctg gacagggtca gtctctatgt caatggcttc 44280 aaccctcgga gctctgtgcc aaccaccagc actcctggga cctccacagt gcacctggca 44340 acctctggga ctccatcctc cctgcctggc cacacancnn ctgnccctct cctgntnccn 44400 ttcaccntca acttnaccat caccaacctg cantangngg annacatgcn ncncccnggn 44460 tccaggaagt tcaacaccac ngagagggtt ctgcagggtc tgctcaaacc cttgttcagg 44520 aatagcagtc tggaatacct ctattcaggc tgcagactag cctcactcag gccagagaag 44580 gatagctcag ccatggcagt ggatgccatc tgcacacatc gccctgaccc tgaagacctc 44640 ggactggaca gagagcgact gtactgggag ctgagcaatc tgacaaatgg catccaggag 44700 ctgggcccct acaccctgga ccggaacagt ctctacgtca atggtttcac ccatcggagc 44760 tctgggctca ccaccagcac tccttggact tccacagttg accttggaac ctcagggact 44820 ccatcccccg tccccagccc cacaactgct ggccctctcc tggtgccatt caccctcaac 44880 ttcaccatca ccaacctgca gtatgaggag gacatgcatc gccctggttc caggaggttc 44940 aacaccacgg agagggttct gcagggtctg ctcacgccct tgttcaagaa caccagtgtt 45000 ggccctctgt actctggctg cagactgacc ttgctcagac ctgagaagca agaggcagcc 45060 actggagtgg acaccatctg tacccaccgc gttgatccca tcggacctgg actggacaga 45120 gagcggctat actgggagct gagccagctg accaacagca tcacagagct gggaccctac 45180 accctggata gggacagtct ctatgtcaat ggcttcaacc cttggagctc tgtgccaacc 45240 accagcactc ctgggacctc cacagtgcac ctggcaacct ctgggactcc atcctccctg 45300 cctggccaca cagcccctgt ccctctcttg ataccattca ccctcaactt taccatcacc 45360 gacctgcatt atgaagaaaa catgcaacac cctggttcca ggaagttcaa caccacggag 45420 agggttctgc agggtctgct caagcccttg ttcaagagca ccagcgttgg ccctctgtac 45480 tctggctgca gactgacctt gctcagacct gagaaacatg gggcagccac tggagtggac 45540 gccatctgca ccctccgcct tgatcccact ggtcctggac tggacagaga gcggctatac 45600 tgggagctga gccagctgac caacagcgtt acagagctgg gcccctacac cctggacagg 45660 gacagtctct atgtcaatgg cttcacccat cggagctctg tgccaaccac cagtattcct 45720 gggacctctg cagtgcacct ggaaacctct gggactccag cctccctccc tggccacaca 45780 gcccctggcc ctctcctggt gccattcacc ctcaacttca ctatcaccaa cctgcagtat 45840 gaggaggaca tgcgtcaccc tggttccagg aagttcagca ccacggagag agtcctgcag 45900 ggtctgctca agcccttgtt caagaacacc agtgtcagct ctctgtactc tggttgcaga 45960 ctgaccttgc tcaggcctga gaaggatggg gcagccacca gagtggatgc tgtctgcacc 46020 catcgtcctg accccaaaag ccctggactg gacagagagc ggctgtactg gaagctgagc 46080 cagctgaccc acggcatcac tgagctgggc ccctacaccc tggacaggca cagtctctat 46140 gtcaatggtt tcacccatca gagctctatg acgaccacca gaactcctga tacctccaca 46200 atgcacctgg caacctcgag aactccagcc tccctgtctg gacctacgac cgccagccct 46260 ctcctggtgc tattcacaat taacttcacc atcactaacc tgcggtatga ggagaacatg 46320 catcaccctg gctctagaaa gtttaacacc acggagagag tccttcaggg tctgctcagg 46380 cctgtgttca agaacaccag tgttggccct ctgtactctg gctgcagact gaccacgctc 46440 aggcccaaga aggatggggc agccaccaaa gtggatgcca tctgcaccta ccgccctgat 46500 cccaaaagcc ctggactgga cagagagcag ctatactggg agctgagcca gctaacccac 46560 agcatcactg agctgggccc ctacacccag gacagggaca gtctctatgt caatggcttc 46620 acccatcgga gctctgtgcc aaccaccagt attcctggga cctctgcagt gcacctggaa 46680 acctctggga ctccagcctc cctccctggc cacacagccc ctggccctct cctggtgcca 46740 ttcaccctca acttcactat caccaacctg cagtatgagg aggacatgcg tcaccctggt 46800 tccaggaagt tcaacaccac ggagagagtc ctgcagggtc tgctcaagcc cttgttcaag 46860 agcaccagtg ttggccctct gtactctggc tgcagactga ccttgctcag gcctgaaaaa 46920 cgtggggcag ccaccggcgt ggacaccatc tgcactcacc gccttgaccc tctaaaccca 46980 ggactggaca gagagcagct atactgggag ctgagcaaac tgacccgtgg catcatcgag 47040 ctgggcccct acctcctgga cagaggcagt ctctatgtca atggtttcac ccatcggacc 47100 tctgtgccca ccaccagcac tcctgggacc tccacagtgg accttggaac ctcagggact 47160 ccattctccc tcccaagccc cgcancnnct gnccctctcc tgntnccntt caccntcaac 47220 ttnaccatca ccaacctgca ntangnggan nacatgcnnc ncccnggntc caggaagttc 47280 aacaccacng agagggtcct gcagactctg cttggtccta tgttcaagaa caccagtgtt 47340 ggccttctgt actctggctg cagactgacc ttgctcaggt ccgagaagga tggagcagcc 47400 actggagtgg atgccatctg cacccaccgt cttgacccca aaagccctgg agtggacagg 47460 gagcaactat actgggagct gagccagctg accaatggca ttaaagaact gggcccctac 47520 accctggaca ggaacagtct ctatgtcaat gggttcaccc attggatccc tgtgcccacc 47580 agcagcactc ctgggacctc cacagtggac cttgggtcag ggactccatc ctccctcccc 47640 agccccacaa ctgctggccc tctcctggtg ccgttcaccc tcaacttcac catcaccaac 47700 ctgaagtacg aggaggacat gcattgccct ggctccagga agttcaacac cacagagaga 47760 gtcctgcaga gtctgcttgg tcccatgttc aagaacacca gtgttggccc tctgtactct 47820 ggctgcagac tgaccttgct caggtccgag aaggatggag cagccactgg agtggatgcc 47880 atctgcaccc accgtcttga ccccaaaagc cctggagtgg acagggagca gctatactgg 47940 gagctgagcc agctgaccaa tggcatcaaa gagctgggtc cctacaccct ggacagaaac 48000 agtctctatg tcaatggttt cacccatcag acctctgcgc ccaacaccag cactcctggg 48060 acctccacag tggaccttgg gacctcaggg actccatcct ccctccccag ccctacancn 48120 nctgnccctc tcctgntncc nttcaccntc aacttnacca tcaccaacct gcantangng 48180 gannacatgc nncncccngg ntccaggaag ttcaacacca cngagngngt nctgcagggt 48240 ctgctnnnnc ccntnttcaa gaacnccagt gtnggccntc tgtactctgg ctgcagactg 48300 acctnnctca ggncngagaa gnatggngca gccactggan tggatgccat ctgcanccac 48360 cnncntnanc ccaaaagncc tggactgnac agngagcngc tntactggga gctnagccan 48420 ctgaccaann ncatcnnnga gctgggnccc tacaccctgg acaggnacag tctctatgtc 48480 aatggtttca cccattggat ccctgtgccc accagcagca ctcctgggac ctccacagtg 48540 gaccttgggt cagggactcc atcctccctc cccagcccca caactgctgg ccctctcctg 48600 gtgccgttca ccctcaactt caccatcacc aacctgaagt acgaggagga catgcattgc 48660 cctggctcca ggaagttcaa caccacagag agagtcctgc agagtctgct tggtcccatg 48720 ttcaagaaca ccagtgttgg ccctctgtac tctggctgca gactgacctc gctcaggtcc 48780 gagaaggatg gagcagccac tggagtggat gccatctgca cccaccgtgt tgaccccaaa 48840 agccctggag tggacaggga gcagctatac tgggagctga gccagctgac caatggcatc 48900 aaagagctgg gtccctacac cctggacaga aacagtctct atgtcaatgg tttcacccat 48960 cagacctctg cgcccaacac cagcactcct gggacctcca cagtgnacnt nggnacctcn 49020 gggactccat cctccntccc cngccncaca tctgctggcc ctctcctggt gccattcacc 49080 ctcaacttca ccatcaccaa cctgcagtac gaggaggaca tgcatcaccc aggctccagg 49140 aagttcaaca ccacggagcg ggtcctgcag ggtctgcttg gtcccatgtt caagaacacc 49200 agtgtcggcc ttctgtactc tggctgcaga ctgaccttgc tcaggcctga gaagaatggg 49260 gcaaccactg gaatggatgc catctgcacc caccgtcttg accccaaaag ccctggactg 49320 nacagngagc ngctntactg ggagctnagc canctgacca annncatcnn ngagctgggn 49380 ccctacaccc tggacaggna cagtctctat gtcaatggtt tcacccatcn ganctctgng 49440 cccaccacca gcactcctgg gacctccaca gtgnacntng gnacctcngg gactccatcc 49500 tccntccccn gccncacanc nnctgnccct ctcctgntnc cnttcaccnt caacttnacc 49560 atcaccaacc tgcantangn ggannacatg cnncncccng gntccaggaa gttcaacacc 49620 acngagaggg ttctgcaggg tctgctcaaa cccttgttca ggaatagcag tctggaatac 49680 ctctattcag gctgcagact agcctcactc aggccagaga aggatagctc agccatggca 49740 gtggatgcca tctgcacaca tcgccctgac cctgaagacc tcggactgga cagagagcga 49800 ctgtactggg agctgagcaa tctgacaaat ggcatccagg agctgggccc ctacaccctg 49860 gaccggaaca gtctctatgt caatggtttc acccatcgaa gctctatgcc caccaccagc 49920 actcctggga cctccacagt ggatgtggga acctcaggga ctccatcctc cagccccagc 49980 cccacgactg ctggccctct cctgatacca ttcaccctca acttcaccat caccaacctg 50040 cagtatgggg aggacatggg tcaccctggc tccaggaagt tcaacaccac agagagggtc 50100 ctgcagggtc tgcttggtcc catattcaag aacaccagtg ttggccctct gtactctggc 50160 tgcagactga cctctctcag gtctgagaag gatggagcag ccactggagt ggatgccatc 50220 tgcatccatc atcttgaccc caaaagccct ggactcaaca gagagcggct gtactgggag 50280 ctgagccaac tgaccaatgg catcaaagag ctgggcccct acaccctgga caggaacagt 50340 ctctatgtca atggtttcac ccatcggacc tctgtgccca ccaccagcac tcctgggacc 50400 tccacagtgg accttggaac ctcagggact ccattctccc tcccaagccc cgcaactgct 50460 ggccctctcc tggtgctgtt caccctcaac ttcaccatca ccaacctgaa gtatgaggag 50520 gacatgcatc gccctggctc caggaagttc aacaccactg agagggtcct gcagactctg 50580 cttggtccta tgttcaagaa caccagtgtt ggccttctgt actctggctg cagactgacc 50640 ttgctcaggt ccgagaagga tggagcagcc actggagtgg atgccatctg cacccaccgt 50700 cttgacccca aaagccctgg actgnacagn gagcngctnt actgggagct nagccanctg 50760 accaannnca tcnnngagct gggnccctac accctggaca ggnacagtct ctatgtcaat 50820 ggtttcaccc atcnganctc tgngcccacc accagcactc ctgggacctc cacagtgnac 50880 ntnggnacct cngggactcc atcctccntc cccngccnca cancnnctgn ccctctcctg 50940 ntnccnttca ccntcaactt naccatcacc aacctgcant angngganna catgcnncnc 51000 ccnggntcca ggaagttcaa caccacngag agagtccttc agggtctgct caggcctgtg 51060 ttcaagaaca ccagtgttgg ccctctgtac tctggctgca gactgacctt gctcaggccc 51120 aagaaggatg gggcagccac caaagtggat gccatctgca cctaccgccc tgatcccaaa 51180 agccctggac tggacagaga gcagctatac tgggagctga gccagctaac ccacagcatc 51240 actgagctgg gcccctacac ccaggacagg gacagtctct atgtcaatgg cttcacccat 51300 cggagctctg tgccaaccac cagtattcct gggacctctg cagtgcacct ggaaaccact 51360 gggactccat cctccttccc cggccacaca gagcctggcc ctctcctgat accattcact 51420 ttcaacttta ccatcaccaa cctgcgttat gaggaaaaca tgcaacaccc tggttccagg 51480 aagttcaaca ccacggagag ggttctgcag ggtctgctca cgcccttgtt caagaacacc 51540 agtgttggcc ctctgtactc tggctgcaga ctgaccttgc tcagacctga gaagcaggag 51600 gcagccactg gagtggacac catctgtacc caccgcgttg atcccatcgg acctggactg 51660 gacagagagc ggctatactg ggagctgagc cagctgacca acagcatcac agagctggga 51720 ccctacaccc tggataggga cagtctctat gtcgatggct tcaacccttg gagctctgtg 51780 ccaaccacca gcactcctgg gacctccaca gtgcacctgg caacctctgg gactccatcc 51840 cccctgcctg gccacacagc ccctgtccct ctcttgatac cattcaccct caactttacc 51900 atcaccgacc tgcattatga agaaaacatg caacaccctg gttccaggaa gttcaacacc 51960 acggagaggg ttctgcaggg tctgctcaag cccttgttca agagcaccag cgttggccct 52020 ctgtactctg gctgcagact gaccttgctc agacctgaga aacatggggc agccactgga 52080 gtggacgcca tctgcaccct ccgccttgat cccactggtc ctggactgga cagagagcgg 52140 ctatactggg agctgagcca gctgaccaac agcatcacag agctgggacc ctacaccctg 52200 gatagggaca gtctctatgt caatggcttc aacccttgga gctctgtgcc aaccaccagc 52260 actcctggga cctccacagt gcacctggca acctctggga ctccatcctc cctgcctggc 52320 cacacaactg ctggccctct cctggtgccg ttcaccctca acttcaccat caccaacctg 52380 aagtacgagg aggacatgca ttgccctggc tccaggaagt tcaacaccac agagagagtc 52440 ctgcagagtc tgcatggtcc catgttcaag aacaccagtg ttggccctct gtactctggc 52500 tgcagactga ccttgctcag gtccgagaag gatggagcag ccactggagt ggatgccatc 52560 tgcacccacc gtcttgaccc caaaagccct ggactgnaca gngagcngct ntactgggag 52620 ctnagccanc tgaccaannn catcnnngag ctgggnccct acaccctgga caggnacagt 52680 ctctatgtca atggtttcac ccatcnganc tctgngccca ccaccagcac tcctgggacc 52740 tccacagtgn acntnggnac ctcngggact ccatcctccn tccccngccn cacancnnct 52800 gnccctctcc tgntnccntt caccntcaac ttnaccatca ccaacctgca ntangnggan 52860 nacatgcnnc ncccnggntc caggaagttc aacaccacng agngngtnct gcagggtctg 52920 ctnnnncccn tnttcaagaa cnccagtgtn ggccntctgt actctggctg cagactgacc 52980 tnnctcaggn cngagaagna tggngcagcc actggantgg atgccatctg canccaccnn 53040 cntnanccca aaagncctgg actgnacagn gagcngctnt actgggagct nagccanctg 53100 accaacagca tcacagagct gggaccctac accctggata gggacagtct ctatgtcaat 53160 ggtttcaccc atcgaagctc tatgcccacc accagtattc ctgggacctc tgcagtgcac 53220 ctggaaacct ctgggactcc agcctccctc cctggccaca cagcccctgg ccctctcctg 53280 gtgccattca ccctcaactt cactatcacc aacctgcagt atgaggagga catgcgtcac 53340 cctggttcca ggaagttcaa caccacggag agagtcctgc agggtctgct caagcccttg 53400 ttcaagagca ccagtgttgg ccctctgtac tctggctgca gactgacctt gctcaggcct 53460 gaaaaacgtg gggcagccac cggcgtggac accatctgca ctcaccgcct tgaccctcta 53520 aaccctggac tgnacagnga gcngctntac tgggagctna gccanctgac caannncatc 53580 nnngagctgg gnccctacac cctggacagg nacagtctct atgtcaatgg tttcacccat 53640 cnganctctg ngcccaccac cagcactcct gggacctcca cagtgnacnt nggnacctcn 53700 gggactccat cctccntccc cngccncaca ncnnctgncc ctctcctgnt nccnttcacc 53760 ntcaacttna ccatcaccaa cctgcantan gnggannaca tgcnncnccc nggntccagg 53820 aagttcaaca ccacngagng ngtnctgcag ggtctgctnn nncccntntt caagaacncc 53880 agtgtnggcc ntctgtactc tggctgcaga ctgacctnnc tcaggncnga gaagnatggn 53940 gcagccactg gantggatgc catctgcanc caccnncntn ancccaaaag ncctggactg 54000 nacagngagc ngctntactg ggagctnagc canctgacca annncatcnn ngagctgggn 54060 ccctacaccc tggacaggna cagtctctat gtcaatggtt ttcaccctcg gagctctgtg 54120 ccaaccacca gcactcctgg gacctccaca gtgcacctgg caacctctgg gactccatcc 54180 tccctgcctg gccacacagc ccctgtccct ctcttgatac cattcaccct caactttacc 54240 atcaccaacc tgcattatga agaaaacatg caacaccctg gttccaggaa gttcaacacc 54300 acggagcggg tcctgcaggg tctgcttggt cccatgttca agaacacaag tgtcggcctt 54360 ctgtactctg gctgcagact gaccttgctc aggcctgaga agaatggggc agccactgga 54420 atggatgcca tctgcagcca ccgtcttgac cccaaaagcc ctggactgna cagngagcng 54480 ctntactggg agctnagcca nctgaccaan nncatcnnng agctgggncc ctacaccctg 54540 gacaggnaca gtctctatgt caatggtttc acccatcnga nctctgngcc caccaccagc 54600 actcctggga cctccacagt gnacntnggn acctcnggga ctccatcctc cntccccngc 54660 cncacancnn ctgnccctct cctgntnccn ttcaccntca acttnaccat caccaacctg 54720 cantangngg annacatgcn ncncccnggn tccaggaagt tcaacaccac ngagngngtn 54780 ctgcagggtc tgctnnnncc cntnttcaag aacnccagtg tnggccntct gtactctggc 54840 tgcagactga cctnnctcag gncngagaag natggngcag ccactggant ggatgccatc 54900 tgcanccacc nncntnancc caaaagncct ggactgnaca gngagcngct ntactgggag 54960 ctnagccanc tgaccaannn catcnnngag ctgggnccct acaccctgga caggnacagt 55020 ctctatgtca atggtttcac ccatcagaac tctgtgccca ccaccagtac tcctgggacc 55080 tccacagtgt actgggcaac cactgggact ccatcctcct tccccggcca cacagagcct 55140 ggccctctcc tgataccatt cactttcaac tttaccatca ccaacctgca ttatgaggaa 55200 aacatgcaac accctggttc caggaagttc aacaccacgg agagggttct gcagggtctg 55260 ctcacgccct tgttcaagaa caccagtgtt ggccctctgt actctggctg cagactgacc 55320 ttgctcagac ctgagaagca ggaggcagcc actggagtgg acaccatctg tacccaccgc 55380 gttgatccca tcggacctgg actgnacagn gagcngctnt actgggagct nagccanctg 55440 accaannnca tcnnngagct gggnccctac accctggaca ggnacagtct ctatgtcaat 55500 ggtttcaccc atcnganctc tgngcccacc accagcactc ctgggacctc cacagtgnac 55560 ntnggnacct cngggactcc atcctccntc cccngccnca cancnnctgn ccctctcctg 55620 ntnccnttca ccntcaactt naccatcacc aacctgcant angngganna catgcnncnc 55680 ccnggntcca ggaagttcaa caccacngag ngngtnctgc agggtctgct nnnncccntn 55740 ttcaagaacn ccagtgtngg ccntctgtac tctggctgca gactgacctn nctcaggncn 55800 gagaagnatg gngcagccac tggantggat gccatctgca nccaccnncn tnancccaaa 55860 agncctggac tgnacagnga gcngctntac tgggagctna gccanctgac caannncatc 55920 nnngagctgg gnccctacac cctggacagg nacagtctct atgtcaatgg tttcacccat 55980 cggagctctg tgccaaccac cagcagtcct gggacctcca cagtgcacct ggcaacctct 56040 gggactccat cctccctgcc tggccacaca gcccctgtcc ctctcttgat accattcacc 56100 ctcaacttta ccatcaccaa cctgcattat gaagaaaaca tgcaacaccc tggttccagg 56160 aagttcaaca ccacggagag ggttctgcag ggtctgctca agcccttgtt caagagcacc 56220 agtgttggcc ctctgtactc tggctgcaga ctgaccttgc tcagacctga gaaacatggg 56280 gcagccactg gagtggacgc catctgcacc ctccgccttg atcccactgg tcctggactg 56340 nacagngagc ngctntactg ggagctnagc canctgacca annncatcnn ngagctgggn 56400 ccctacaccc tggacaggna cagtctctat gtcaatggtt tcacccatcn ganctctgng 56460 cccaccacca gcactcctgg gacctccaca gtgnacntng gnacctcngg gactccatcc 56520 tccntccccn gccncacanc nnctgnccct ctcctgntnc cnttcaccnt caacttnacc 56580 atcaccaacc tgcantangn ggannacatg cnncncccng gntccaggaa gttcaacacc 56640 acngagngng tnctgcaggg tctgctnnnn cccntnttca agaacnccag tgtnggccnt 56700 ctgtactctg gctgcagact gacctnnctc aggncngaga agnatggngc agccactgga 56760 ntggatgcca tctgcancca ccnncntnan cccaaaagnc ctggactgna cagngagcng 56820 ctntactggg agctnagcca nctgaccaan nncatcnnng agctgggncc ctacaccctg 56880 gacaggnaca gtctctatgt caatggtttc acccatcgga cctctgtgcc caccaccagc 56940 actcctggga cctccacagt gcacctggca acctctggga ctccatcctc cctgcctggc 57000 cacacagccc ctgtccctct cttgatacca ttcaccctca actttaccat caccaacctg 57060 cagtatgagg aggacatgca tcgccctgga tctaggaagt tcaacaccac agagagggtc 57120 ctgcagggtc tgcttagtcc cattttcaag aactccagtg ttggccctct gtactctggc 57180 tgcagactga cctctctcag gcccgagaag gatggggcag caactggaat ggatgctgtc 57240 tgcctctacc accctaatcc caaaagacct gggctggaca gagagcagct gtactgcgag 57300 ctaagccagc tgacccacaa catcactgag ctgggcccct acagcctgga cagggacagt 57360 ctctatgtca atggtttcac ccatcagaac tctgtgccca ccaccagtac tcctgggacc 57420 tccacagtgt actgggcaac cactgggact ccatcctcct tccccggcca cacancnnct 57480 gnccctctcc tgntnccntt caccntcaac ttnaccatca ccaacctgca ntangnggan 57540 nacatgcnnc ncccnggntc caggaagttc aacaccacng agngngtnct gcagggtctg 57600 ctnnnncccn tnttcaagaa cnccagtgtn ggccntctgt actctggctg cagactgacc 57660 tnnctcaggn cngagaagna tggngcagcc actggantgg atgccatctg canccaccnn 57720 cntnanccca aaagncctgg actgnacagn gagcngctnt actgggagct nagccanctg 57780 accaannnca tcnnngagct gggnccctac accctggaca ggnacagtct ctatgtcaat 57840 ggtttcaccc attggagctc tgggctcacc accagcactc cttggacttc cacagttgac 57900 cttggaacct cagggactcc atcccccgtc cccagcccca caactgctgg ccctctcctg 57960 gtgccattca ccctaaactt caccatcacc aacctgcagt atgaggagga catgcatcgc 58020 cctggatcta ggaagttcaa cgccacagag agggtcctgc agggtctgct tagtcccata 58080 ttcaagaaca ccagtgttgg ccctctgtac tctggctgca gactgacctt gctcagacct 58140 gagaagcagg aggcagccac tggagtggac accatctgta cccaccgcgt tgatcccatc 58200 ggacctggac tgnacagnga gcngctntac tgggagctna gccanctgac caannncatc 58260 nnngagctgg gnccctacac cctggacagg nacagtctct atgtcaatgg tttcacccat 58320 cnganctctg ngcccaccac cagcactcct gggacctcca cagtgnacnt nggnacctcn 58380 gggactccat cctccntccc cngccncaca ncnnctgncc ctctcctgnt nccnttcacc 58440 ntcaacttna ccatcaccaa cctgcantan gnggannaca tgcnncnccc nggntccagg 58500 aagttcaaca ccacngagng ngtnctgcag ggtctgctnn nncccntntt caagaacncc 58560 agtgtnggcc ntctgtactc tggctgcaga ctgacctnnc tcaggncnga gaagnatggn 58620 gcagccactg gantggatgc catctgcanc caccnncntn ancccaaaag ncctggactg 58680 nacagngagc ngctntactg ggagctnagc canctgacca annncatcnn ngagctgggn 58740 ccctacaccc tggacaggna cagtctctat gtcaatggtt tcacccatcg gagctttggg 58800 ctcaccacca gcactccttg gacttccaca gttgaccttg gaacctcagg gactccatcc 58860 cccgtcccca gccccacaac tgctggccct ctcctggtgc cattcaccct aaacttcacc 58920 atcaccaacc tgcagtatga ggaggacatg catcgccctg gctccaggaa gttcaacacc 58980 acggagaggg tccttcaggg tctgcttacg cccttgttca ggaacaccag tgtcagctct 59040 ctgtactctg gttgcagact gaccttgctc aggcctgaga aggatggggc agccaccaga 59100 gtggatgctg tctgcaccca tcgtcctgac cccaaaagcc ctggactgna cagngagcng 59160 ctntactggg agctnagcca nctgaccaan nncatcnnng agctgggncc ctacaccctg 59220 gacaggnaca gtctctatgt caatggtttc acccatcnga nctctgngcc caccaccagc 59280 actcctggga cctccacagt gnacntnggn acctcnggga ctccatcctc cntccccngc 59340 cncacancnn ctgnccctct cctgntnccn ttcaccntca acttnaccat caccaacctg 59400 cantangngg annacatgcn ncncccnggn tccaggaagt tcaacaccac ngagngngtn 59460 ctgcagggtc tgctnnnncc cntnttcaag aacnccagtg tnggccntct gtactctggc 59520 tgcagactga cctnnctcag gncngagaag natggngcag ccactggant ggatgccatc 59580 tgcanccacc nncntnancc caaaagncct ggactgnaca gngagcngct ntactgggag 59640 ctnagccanc tgaccaannn catcnnngag ctgggnccct acaccctgga caggnacagt 59700 ctctatgtca atggtttcac ccattggatc cctgtgccca ccagcagcac tcctgggacc 59760 tccacagtgg accttgggtc agggactcca tcctccctcc ccagccccac aactgctggc 59820 cctctcctgg taccattcac cctcaacttc accatcacca acctgcagta tggggaggac 59880 atgggtcacc ctggctccag gaagttcaac accacagaga gggtcctgca gggtctgctt 59940 ggtcccatat tcaagaacac cagtgttggc cctctgtact ctggctgcag actgacctct 60000 ctcaggtccg agaaggatgg agcagccact ggagtggatg ccatctgcat ccatcatctt 60060 gaccccaaaa gccctggact gnacagngag cngctntact gggagctnag ccanctgacc 60120 aannncatcn nngagctggg nccctacacc ctggacaggn acagtctcta tgtcaatggt 60180 ttcacccatc nganctctgn gcccaccacc agcactcctg ggacctccac agtgnacntn 60240 ggnacctcng ggactccatc ctccntcccc ngccncacan cnnctgnccc tctcctgntn 60300 ccnttcaccn tcaacttnac catcaccaac ctgcantang nggannacat gcnncncccn 60360 ggntccagga agttcaacac cacngagngn gtnctgcagg gtctgctnnn ncccntnttc 60420 aagaacncca gtgtnggccn tctgtactct ggctgcagac tgacctnnct caggncngag 60480 aagnatggng cagccactgg antggatgcc atctgcancc accnncntna ncccaaaagn 60540 cctggactgn acagngagcn gctntactgg gagctnagcc anctgaccaa nnncatcnnn 60600 gagctgggnc cctacaccct ggacaggnac agtctctatg tcaatggttt cacccatcag 60660 acctttgcgc ccaacaccag cactcctggg acctccacag tggaccttgg gacctcaggg 60720 actccatcct ccctccccag ccctacatct gctggccctc tcctggtgcc attcaccctc 60780 aacttcacca tcaccaacct gcagtacgag gaggacatgc atcacccagg ctccaggaag 60840 ttcaacacca cggagcgggt cctgcagggt ctgcttggtc ccatgttcaa gaacaccagt 60900 gtcggccttc tgtactctgg ctgcagactg accttgctca ggcctgagaa gaatggggca 60960 gccaccagag tggatgctgt ctgcacccat cgtcctgacc ccaaaagccc tggactgnac 61020 agngagcngc tntactggga gctnagccan ctgaccaann ncatcnnnga gctgggnccc 61080 tacaccctgg acaggnacag tctctatgtc aatggtttca cccatcngan ctctgngccc 61140 accaccagca ctcctgggac ctccacagtg nacntnggna cctcngggac tccatcctcc 61200 ntccccngcc ncacagcccc tgtccctctc ttgataccat tcaccctcaa ctttaccatc 61260 accaacctgc attatgaaga aaacatgcaa caccctggtt ccaggaagtt caacaccacg 61320 gagagggttc tgcagggtct gctcaagccc ttgttcaaga gcaccagcgt tggccctctg 61380 tactctggct gcagactgac cttgctcaga cctgagaaac atggggcagc cactggagtg 61440 gacgccatct gcaccctccg ccttgatccc actggtcctg gactggacag agagcggcta 61500 tactgggagc tgagccagct gaccaacagc gttacagagc tgggccccta caccctggac 61560 agggacagtc tctatgtcaa tggcttcacc cagcggagct ctgtgccaac caccagtatt 61620 cctgggacct ctgcagtgca cctggaaacc tctgggactc cagcctccct ccctggccac 61680 acagcccctg gccctctcct ggtgccattc accctcaact tcactatcac caacctgcag 61740 tatgaggtgg acatgcgtca ccctggttcc aggaagttca acaccacgga gagagtcctg 61800 cagggtctgc tcaagccctt gttcaagagc accagtgttg gccctctgta ctctggctgc 61860 agactgacct tgctcaggcc tgaaaaacgt ggggcagcca ccggcgtgga caccatctgc 61920 actcaccgcc ttgaccctct aaaccctgga ctggacagag agcagctata ctgggagctg 61980 agcaaactga cccgtggcat catcgagctg ggcccctacc tcctggacag aggcagtctc 62040 tatgtcaatg gtttcaccca tcggaacttt gtgcccatca ccagcactcc tgggacctcc 62100 acagtacacc taggaacctc tgaaactcca tcctccctac ctagacccat agtgcctggc 62160 cctctcctgg tgccattcac cctcaacttc accatcacca acttgcagta tgaggaggcc 62220 atgcgacacc ctggctccag gaagttcaat accacggaga gggtcctaca gggtctgctc 62280 aggcccttgt tcaagaatac cagtatcggc cctctgtact ccagctgcag actgaccttg 62340 ctcaggccag agaaggacaa ggcagccacc agagtggatg ccatctgtac ccaccaccct 62400 gaccctcaaa gccctggact gaacagagag cagctgtact gggagctgag ccagctgacc 62460 cacggcatca ctgagctggg cccctacacc ctggacaggg acagtctcta tgtcgatggt 62520 ttcactcatt ggagccccat accgaccacc agcactcctg ggacctccat agtgaacctg 62580 ggaacctctg ggatcccacc ttccctccct gaaactacan cnnctgnccc tctcctgntn 62640 ccnttcaccn tcaacttnac catcaccaac ctgcantang nggannacat gcnncncccn 62700 ggntccagga agttcaacac cacngagagg gttctgcagg gtctgctcaa gcccttgttc 62760 aagagcacca gtgttggccc tctgtattct ggctgcagac tgaccttgct caggcctgag 62820 aaggacggag tagccaccag agtggacgcc atctgcaccc accgccctga ccccaaaatc 62880 cctgggctag acagacagca gctatactgg gagctgagcc agctgaccca cagcatcact 62940 gagctgggac cctacaccct ggatagggac agtctctatg tcaatggttt cacccagcgg 63000 agctctgtgc ccaccaccag cactcctggg actttcacag tacagccgga aacctctgag 63060 actccatcat ccctccctgg ccccacagcc actggccctg tcctgctgcc attcaccctc 63120 aattttacca tcactaacct gcagtatgag gaggacatgc atcgccctgg ctccaggaag 63180 ttcaacacca cggagagggt ccttcagggt ctgcttatgc ccttgttcaa gaacaccagt 63240 gtcagctctc tgtactctgg ttgcagactg accttgctca ggcctgagaa ggatggggca 63300 gccaccagag tggatgctgt ctgcacccat cgtcctgacc ccaaaagccc tggactggac 63360 agagagcggc tgtactggaa gctgagccag ctgacccacg gcatcactga gctgggcccc 63420 tacaccctgg acaggcacag tctctatgtc aatggtttca cccatcagag ctctatgacg 63480 accaccagaa ctcctgatac ctccacaatg cacctggcaa cctcgagaac tccagcctcc 63540 ctgtctggac ctacgaccgc cagccctctc ctggtgctat tcacaattaa cttcaccatc 63600 actaacctgc ggtatgagga gaacatgcat caccctggct ctagaaagtt taacaccacg 63660 gagagagtcc ttcagggtct gctcaggcct gtgttcaaga acaccagtgt tggccctctg 63720 tactctggct gcagactgac cttgctcagg cccaagaagg atggggcagc caccaaagtg 63780 gatgccatct gcacctaccg ccctgatccc aaaagccctg gactggacag agagcagcta 63840 tactgggagc tgagccagct aacccacagc atcactgagc tgggccccta caccctggac 63900 agggacagtc tctatgtcaa tggtttcaca cagcggagct ctgtgcccac cactagcatt 63960 cctgggaccc ccacagtgga cctgggaaca tctgggactc cagtttctaa acctggtccc 64020 tcggctgcca gccctctcct ggtgctattc actctcaact tcaccatcac caacctgcgg 64080 tatgaggaga acatgcagca ccctggctcc aggaagttca acaccacgga gagggtcctt 64140 cagggcctgc tcaggtccct gttcaagagc accagtgttg gccctctgta ctctggctgc 64200 agactgactt tgctcaggcc tgaaaaggat gggacagcca ctggagtgga tgccatctgc 64260 acccaccacc ctgaccccaa aagccctagg ctggacagag agcagctgta ttgggagctg 64320 agccagctga cccacaatat cactgagctg ggccactatg ccctggacaa cgacagcctc 64380 tttgtcaatg gtttcactca tcggagctct gtgtccacca ccagcactcc tgggaccccc 64440 acagtgtatc tgggagcatc taagactcca gcctcgatat ttggcccttc agctgccagc 64500 catctcctga tactattcac cctcaacttc accatcacta acctgcggta tgaggagaac 64560 atgtggcctg gctccaggaa gttcaacact acagagaggg tccttcaggg cctgctaagg 64620 cccttgttca agaacaccag tgttggccct ctgtactctg gctccaggct gaccttgctc 64680 aggccagaga aagatgggga agccaccgga gtggatgcca tctgcaccca ccgccctgac 64740 cccacaggcc ctgggctgga cagagagcag ctgtatttgg agctgagcca gctgacccac 64800 agcatcactg agctgggccc ctacacactg gacagggaca gtctctatgt caatggtttc 64860 acccatcgga gctctgtacc caccaccagc accggggtgg tcagcgagga gccattcaca 64920 ctgaacttca ccatcaacaa cctgcgctac atggcggaca tgggccaacc cggctccctc 64980 aagttcaaca tcacagacaa cgtcatgaag cacctgctca gtcctttgtt ccagaggagc 65040 agcctgggtg cacggtacac aggctgcagg gtcatcgcac taaggtctgt gaagaacggt 65100 gctgagacac gggtggacct cctctgcacc tacctgcagc ccctcagcgg cccaggtctg 65160 cctatcaagc aggtgttcca tgagctgagc cagcagaccc atggcatcac ccggctgggc 65220 ccctactctc tggacaaaga cagcctctac cttaacggtt acaatgaacc tggtctagat 65280 gagcctccta caactcccaa gccagccacc acattcctgc ctcctctgtc agaagccaca 65340 acagccatgg ggtaccacct gaagaccctc acactcaact tcaccatctc caatctccag 65400 tattcaccag atatgggcaa gggctcagct acattcaact ccaccgaggg ggtccttcag 65460 cacctgctca gacccttgtt ccagaagagc agcatgggcc ccttctactt gggttgccaa 65520 ctgatctccc tcaggcctga gaaggatggg gcagccactg gtgtggacac cacctgcacc 65580 taccaccctg accctgtggg ccccgggctg gacatacagc agctttactg ggagctgagt 65640 cagctgaccc atggtgtcac ccaactgggc ttctatgtcc tggacaggga tagcctcttc 65700 atcaatggct atgcacccca gaatttatca atccggggcg agtaccagat aaatttccac 65760 attgtcaact ggaacctcag taatccagac cccacatcct cagagtacat caccctgctg 65820 agggacatcc aggacaaggt caccacactc tacaaaggca gtcaactaca tgacacattc 65880 cgcttctgcc tggtcaccaa cttgacgatg gactccgtgt tggtcactgt caaggcattg 65940 ttctcctcca atttggaccc cagcctggtg gagcaagtct ttctagataa gaccctgaat 66000 gcctcattcc attggctggg ctccacctac cagttggtgg acatccatgt gacagaaatg 66060 gagtcatcag tttatcaacc aacaagcagc tccagcaccc agcacttcta cctgaatttc 66120 accatcacca acctaccata ttcccaggac aaagcccagc caggcaccac caattaccag 66180 aggaacaaaa ggaatattga ggatgcgctc aaccaactct tccgaaacag cagcatcaag 66240 agttattttt ctgactgtca agtttcaaca ttcaggtctg tccccaacag gcaccacacc 66300 ggggtggact ccctgtgtaa cttctcgcca ctggctcgga gagtagacag agttgccatc 66360 tatgaggaat ttctgcggat gacccggaat ggtacccagc tgcagaactt caccctggac 66420 aggagcagtg tccttgtgga tgggtattct cccaacagaa atgagccctt aactgggaat 66480 tctgaccttc ccttctgggc tgtcatcctc atcggcttgg caggactcct gggactcatc 66540 acatgcctga tctgcggtgt cctggtgacc acccgccggc ggaagaagga aggagaatac 66600 aacgtccagc aacagtgccc aggctactac cagtcacacc tagacctgga ggatctgcaa 66660 tgactggaac ttgccggtgc ctggggtgcc tttcccccag ccagggtcca aagaagcttg 66720 gctggggcag aaataaacca tattggtcgg aaaaaaaaaa aaaaa 66765 5 22152 PRT Homo sapiens misc_feature (13880)..(13880) Xaa can be any naturally occurring amino acid 5 Met Leu Lys Pro Ser Gly Leu Pro Gly Ser Ser Ser Pro Thr Arg Ser 1 5 10 15 Leu Met Thr Gly Ser Arg Ser Thr Lys Ala Thr Pro Glu Met Asp Ser 20 25 30 Gly Leu Thr Gly Ala Thr Leu Ser Pro Lys Thr Ser Thr Gly Ala Ile 35 40 45 Val Val Thr Glu His Thr Leu Pro Phe Thr Ser Pro Asp Lys Thr Leu 50 55 60 Ala Ser Pro Thr Ser Ser Val Val Gly Arg Thr Thr Gln Ser Leu Gly 65 70 75 80 Val Met Ser Ser Ala Leu Pro Glu Ser Thr Ser Arg Gly Met Thr His 85 90 95 Ser Glu Gln Arg Thr Ser Pro Ser Leu Ser Pro Gln Val Asn Gly Thr 100 105 110 Pro Ser Arg Asn Tyr Pro Ala Thr Ser Met Val Ser Gly Leu Ser Ser 115 120 125 Pro Arg Thr Arg Thr Ser Ser Thr Glu Gly Asn Phe Thr Lys Glu Ala 130 135 140 Ser Thr Tyr Thr Leu Thr Val Glu Thr Thr Ser Gly Pro Val Thr Glu 145 150 155 160 Lys Tyr Thr Val Pro Thr Glu Thr Ser Thr Thr Glu Gly Asp Ser Thr 165 170 175 Glu Thr Pro Trp Asp Thr Arg Tyr Ile Pro Val Lys Ile Thr Ser Pro 180 185 190 Met Lys Thr Phe Ala Asp Ser Thr Ala Ser Lys Glu Asn Ala Pro Val 195 200 205 Ser Met Thr Pro Ala Glu Thr Thr Val Thr Asp Ser His Thr Pro Gly 210 215 220 Arg Thr Asn Pro Ser Phe Gly Thr Leu Tyr Ser Ser Phe Leu Asp Leu 225 230 235 240 Ser Pro Lys Gly Thr Pro Asn Ser Arg Gly Glu Thr Ser Leu Glu Leu 245 250 255 Ile Leu Ser Thr Thr Gly Tyr Pro Phe Ser Ser Pro Glu Pro Gly Ser 260 265 270 Ala Gly His Ser Arg Ile Ser Thr Ser Ala Pro Leu Ser Ser Ser Ala 275 280 285 Ser Val Leu Asp Asn Lys Ile Ser Glu Thr Ser Ile Phe Ser Gly Gln 290 295 300 Ser Leu Thr Ser Pro Leu Ser Pro Gly Val Pro Glu Ala Arg Ala Ser 305 310 315 320 Thr Met Pro Asn Ser Ala Ile Pro Phe Ser Met Thr Leu Ser Asn Ala 325 330 335 Glu Thr Ser Ala Glu Arg Val Arg Ser Thr Ile Ser Ser Leu Gly Thr 340 345 350 Pro Ser Ile Ser Thr Lys Gln Thr Ala Glu Thr Ile Leu Thr Phe His 355 360 365 Ala Phe Ala Glu Thr Met Asp Ile Pro Ser Thr His Ile Ala Lys Thr 370 375 380 Leu Ala Ser Glu Trp Leu Gly Ser Pro Gly Thr Leu Gly Gly Thr Ser 385 390 395 400 Thr Ser Ala Leu Thr Thr Thr Ser Pro Ser Thr Thr Leu Val Ser Glu 405 410 415 Glu Thr Asn Thr His His Ser Thr Ser Gly Lys Glu Thr Glu Gly Thr 420 425 430 Leu Asn Thr Ser Met Thr Pro Leu Glu Thr Ser Ala Pro Gly Glu Glu 435 440 445 Ser Glu Met Thr Ala Thr Leu Val Pro Thr Leu Gly Phe Thr Thr Leu 450 455 460 Asp Ser Lys Ile Arg Ser Pro Ser Gln Val Ser Ser Ser His Pro Thr 465 470 475 480 Arg Glu Leu Arg Thr Thr Gly Ser Thr Ser Gly Arg Gln Ser Ser Ser 485 490 495 Thr Ala Ala His Gly Ser Ser Asp Ile Leu Arg Ala Thr Thr Ser Ser 500 505 510 Thr Ser Lys Ala Ser Ser Trp Thr Ser Glu Ser Thr Ala Gln Gln Phe 515 520 525 Ser Glu Pro Gln His Thr Gln Trp Val Glu Thr Ser Pro Ser Met Lys 530 535 540 Thr Glu Arg Pro Pro Ala Ser Thr Ser Val Ala Ala Pro Ile Thr Thr 545 550 555 560 Ser Val Pro Ser Val Val Ser Gly Phe Thr Thr Leu Lys Thr Ser Ser 565 570 575 Thr Lys Gly Ile Trp Leu Glu Glu Thr Ser Ala Asp Thr Leu Ile Gly 580 585 590 Glu Ser Thr Ala Gly Pro Thr Thr His Gln Phe Ala Val Pro Thr Gly 595 600 605 Ile Ser Met Thr Gly Gly Ser Ser Thr Arg Gly Ser Gln Gly Thr Thr 610 615 620 His Leu Leu Thr Arg Ala Thr Ala Ser Ser Glu Thr Ser Ala Asp Leu 625 630 635 640 Thr Leu Ala Thr Asn Gly Val Pro Val Ser Val Ser Pro Ala Val Ser 645 650 655 Lys Thr Ala Ala Gly Ser Ser Pro Pro Gly Gly Thr Lys Pro Ser Tyr 660 665 670 Thr Met Val Ser Ser Val Ile Pro Glu Thr Ser Ser Leu Gln Ser Ser 675 680 685 Ala Phe Arg Glu Gly Thr Ser Leu Gly Leu Thr Pro Leu Asn Thr Arg 690 695 700 His Pro Phe Ser Ser Pro Glu Pro Asp Ser Ala Gly His Thr Lys Ile 705 710 715 720 Ser Thr Ser Ile Pro Leu Leu Ser Ser Ala Ser Val Leu Glu Asp Lys 725 730 735 Val Ser Ala Thr Ser Thr Phe Ser His His Lys Ala Thr Ser Ser Ile 740 745 750 Thr Thr Gly Thr Pro Glu Ile Ser Thr Lys Thr Lys Pro Ser Ser Ala 755 760 765 Val Leu Ser Ser Met Thr Leu Ser Asn Ala Ala Thr Ser Pro Glu Arg 770 775 780 Val Arg Asn Ala Thr Ser Pro Leu Thr His Pro Ser Pro Ser Gly Glu 785 790 795 800 Glu Thr Ala Gly Ser Val Leu Thr Leu Ser Thr Ser Ala Glu Thr Thr 805 810 815 Asp Ser Pro Asn Ile His Pro Thr Gly Thr Leu Thr Ser Glu Ser Ser 820 825 830 Glu Ser Pro Ser Thr Leu Ser Leu Pro Ser Val Ser Gly Val Lys Thr 835 840 845 Thr Phe Ser Ser Ser Thr Pro Ser Thr His Leu Phe Thr Ser Gly Glu 850 855 860 Glu Thr Glu Glu Thr Ser Asn Pro Ser Val Ser Gln Pro Glu Thr Ser 865 870 875 880 Val Ser Arg Val Arg Thr Thr Leu Ala Ser Thr Ser Val Pro Thr Pro 885 890 895 Val Phe Pro Thr Met Asp Thr Trp Pro Thr Arg Ser Ala Gln Phe Ser 900 905 910 Ser Ser His Leu Val Ser Glu Leu Arg Ala Thr Ser Ser Thr Ser Val 915 920 925 Thr Asn Ser Thr Gly Ser Ala Leu Pro Lys Ile Ser His Leu Thr Gly 930 935 940 Thr Ala Thr Met Ser Gln Thr Asn Arg Asp Thr Phe Asn Asp Ser Ala 945 950 955 960 Ala Pro Gln Ser Thr Thr Trp Pro Glu Thr Ser Pro Arg Phe Lys Thr 965 970 975 Gly Leu Pro Ser Ala Thr Thr Thr Val Ser Thr Ser Ala Thr Ser Leu 980 985 990 Ser Ala Thr Val Met Val Ser Lys Phe Thr Ser Pro Ala Thr Ser Ser 995 1000 1005 Met Glu Ala Thr Ser Ile Arg Glu Pro Ser Thr Thr Ile Leu Thr 1010 1015 1020 Thr Glu Thr Thr Asn Gly Pro Gly Ser Met Ala Val Ala Ser Thr 1025 1030 1035 Asn Ile Pro Ile Gly Lys Gly Tyr Ile Thr Glu Gly Arg Leu Asp 1040 1045 1050 Thr Ser His Leu Pro Ile Gly Thr Thr Ala Ser Ser Glu Thr Ser 1055 1060 1065 Met Asp Phe Thr Met Ala Lys Glu Ser Val Ser Met Ser Val Ser 1070 1075 1080 Pro Ser Gln Ser Met Asp Ala Ala Gly Ser Ser Thr Pro Gly Arg 1085 1090 1095 Thr Ser Gln Phe Val Asp Thr Phe Ser Asp Asp Val Tyr His Leu 1100 1105 1110 Thr Ser Arg Glu Ile Thr Ile Pro Arg Asp Gly Thr Ser Ser Ala 1115 1120 1125 Leu Thr Pro Gln Met Thr Ala Thr His Pro Pro Ser Pro Asp Pro 1130 1135 1140 Gly Ser Ala Arg Ser Thr Trp Leu Gly Ile Leu Ser Ser Ser Pro 1145 1150 1155 Ser Ser Pro Thr Pro Lys Val Thr Met Ser Ser Thr Phe Ser Thr 1160 1165 1170 Gln Arg Val Thr Thr Ser Met Ile Met Asp Thr Val Glu Thr Ser 1175 1180 1185 Arg Trp Asn Met Pro Asn Leu Pro Ser Thr Thr Ser Leu Thr Pro 1190 1195 1200 Ser Asn Ile Pro Thr Ser Gly Ala Ile Gly Lys Ser Thr Leu Val 1205 1210 1215 Pro Leu Asp Thr Pro Ser Pro Ala Thr Ser Leu Glu Ala Ser Glu 1220 1225 1230 Gly Gly Leu Pro Thr Leu Ser Thr Tyr Pro Glu Ser Thr Asn Thr 1235 1240 1245 Pro Ser Ile His Leu Gly Ala His Ala Ser Ser Glu Ser Pro Ser 1250 1255 1260 Thr Ile Asn Leu Thr Met Ala Ser Val Val Lys Pro Gly Ser Tyr 1265 1270 1275 Thr Pro Leu Thr Phe Pro Ser Ile Glu Thr His Ile His Val Ser 1280 1285 1290 Thr Ala Arg Met Ala Tyr Ser Ser Gly Ser Ser Pro Glu Met Thr 1295 1300 1305 Ala Pro Gly Glu Thr Asn Thr Gly Ser Thr Trp Asp Pro Thr Thr 1310 1315 1320 Tyr Ile Thr Thr Thr Asp Pro Lys Asp Thr Ser Ser Ala Gln Val 1325 1330 1335 Ser Thr Pro His Ser Val Arg Thr Leu Arg Thr Thr Glu Asn His 1340 1345 1350 Pro Lys Thr Glu Ser Ala Thr Pro Ala Ala Tyr Ser Gly Ser Pro 1355 1360 1365 Lys Ile Ser Ser Ser Pro Asn Leu Thr Ser Pro Ala Thr Lys Ala 1370 1375 1380 Trp Thr Ile Thr Asp Thr Thr Glu His Ser Thr Gln Leu His Tyr 1385 1390 1395 Thr Lys Leu Ala Glu Lys Ser Ser Gly Phe Glu Thr Gln Ser Ala 1400 1405 1410 Pro Gly Pro Val Ser Val Val Ile Pro Thr Ser Pro Thr Ile Gly 1415 1420 1425 Ser Ser Thr Leu Glu Leu Thr Ser Asp Val Pro Gly Glu Pro Leu 1430 1435 1440 Val Leu Ala Pro Ser Glu Gln Thr Thr Ile Thr Leu Pro Met Ala 1445 1450 1455 Thr Trp Leu Ser Thr Ser Leu Thr Glu Glu Met Ala Ser Thr Asp 1460 1465 1470 Leu Asp Ile Ser Ser Pro Ser Ser Pro Met Ser Thr Phe Ala Ile 1475 1480 1485 Phe Pro Pro Met Ser Thr Pro Ser His Glu Leu Ser Lys Ser Glu 1490 1495 1500 Ala Asp Thr Ser Ala Ile Arg Asn Thr Asp Ser Thr Thr Leu Asp 1505 1510 1515 Gln His Leu Gly Ile Arg Ser Leu Gly Arg Thr Gly Asp Leu Thr 1520 1525 1530 Thr Val Pro Ile Thr Pro Leu Thr Thr Thr Trp Thr Ser Val Ile 1535 1540 1545 Glu His Ser Thr Gln Ala Gln Asp Thr Leu Ser Ala Thr Met Ser 1550 1555 1560 Pro Thr His Val Thr Gln Ser Leu Lys Asp Gln Thr Ser Ile Pro 1565 1570 1575 Ala Ser Ala Ser Pro Ser His Leu Thr Glu Val Tyr Pro Glu Leu 1580 1585 1590 Gly Thr Gln Gly Arg Ser Ser Ser Glu Ala Thr Thr Phe Trp Lys 1595 1600 1605 Pro Ser Thr Asp Thr Leu Ser Arg Glu Ile Glu Thr Gly Pro Thr 1610 1615 1620 Asn Ile Gln Ser Thr Pro Pro Met Asp Asn Thr Thr Thr Gly Ser 1625 1630 1635 Ser Ser Ser Gly Val Thr Leu Gly Ile Ala His Leu Pro Ile Gly 1640 1645 1650 Thr Ser Ser Pro Ala Glu Thr Ser Thr Asn Met Ala Leu Glu Arg 1655 1660 1665 Arg Ser Ser Thr Ala Thr Val Ser Met Ala Gly Thr Met Gly Leu 1670 1675 1680 Leu Val Thr Ser Ala Pro Gly Arg Ser Ile Ser Gln Ser Leu Gly 1685 1690 1695 Arg Val Ser Ser Val Leu Ser Glu Ser Thr Thr Glu Gly Val Thr 1700 1705 1710 Asp Ser Ser Lys Gly Ser Ser Pro Arg Leu Asn Thr Gln Gly Asn 1715 1720 1725 Thr Ala Leu Ser Ser Ser Leu Glu Pro Ser Tyr Ala Glu Gly Ser 1730 1735 1740 Gln Met Ser Thr Ser Ile Pro Leu Thr Ser Ser Pro Thr Thr Pro 1745 1750 1755 Asp Val Glu Phe Ile Gly Gly Ser Thr Phe Trp Thr Lys Glu Val 1760 1765 1770 Thr Thr Val Met Thr Ser Asp Ile Ser Lys Ser Ser Ala Arg Thr 1775 1780 1785 Glu Ser Ser Ser Ala Thr Leu Met Ser Thr Ala Leu Gly Ser Thr 1790 1795 1800 Glu Asn Thr Gly Lys Glu Lys Leu Arg Thr Ala Ser Met Asp Leu 1805 1810 1815 Pro Ser Pro Thr Pro Ser Met Glu Val Thr Pro Trp Ile Ser Leu 1820 1825 1830 Thr Leu Ser Asn Ala Pro Asn Thr Thr Asp Ser Leu Asp Leu Ser 1835 1840 1845 His Gly Val His Thr Ser Ser Ala Gly Thr Leu Ala Thr Asp Arg 1850 1855 1860 Ser Leu Asn Thr Gly Val Thr Arg Ala Ser Arg Leu Glu Asn Gly 1865 1870 1875 Ser Asp Thr Ser Ser Lys Ser Leu Ser Met Gly Asn Ser Thr His 1880 1885 1890 Thr Ser Met Thr Asp Thr Glu Lys Ser Glu Val Ser Ser Ser Ile 1895 1900 1905 His Pro Arg Pro Glu Thr Ser Ala Pro Gly Ala Glu Thr Thr Leu 1910 1915 1920 Thr Ser Thr Pro Gly Asn Arg Ala Ile Ser Leu Thr Leu Pro Phe 1925 1930 1935 Ser Ser Ile Pro Val Glu Glu Val Ile Ser Thr Gly Ile Thr Ser 1940 1945 1950 Gly Pro Asp Ile Asn Ser Ala Pro Met Thr His Ser Pro Ile Thr 1955 1960 1965 Pro Pro Thr Ile Val Trp Thr Ser Thr Gly Thr Ile Glu Gln Ser 1970 1975 1980 Thr Gln Pro Leu His Ala Val Ser Ser Glu Lys Val Ser Val Gln 1985 1990 1995 Thr Gln Ser Thr Pro Tyr Val Asn Ser Val Ala Val Ser Ala Ser 2000 2005 2010 Pro Thr His Glu Asn Ser Val Ser Ser Gly Ser Ser Thr Ser Ser 2015 2020 2025 Pro Tyr Ser Ser Ala Ser Leu Glu Ser Leu Asp Ser Thr Ile Ser 2030 2035 2040 Arg Arg Asn Ala Ile Thr Ser Trp Leu Trp Asp Leu Thr Thr Ser 2045 2050 2055 Leu Pro Thr Thr Thr Trp Pro Ser Thr Ser Leu Ser Glu Ala Leu 2060 2065 2070 Ser Ser Gly His Ser Gly Val Ser Asn Pro Ser Ser Thr Thr Thr 2075 2080 2085 Glu Phe Pro Leu Phe Ser Ala Ala Ser Thr Ser Ala Ala Lys Gln 2090 2095 2100 Arg Asn Pro Glu Thr Glu Thr His Gly Pro Gln Asn Thr Ala Ala 2105 2110 2115 Ser Thr Leu Asn Thr Asp Ala Ser Ser Val Thr Gly Leu Ser Glu 2120 2125 2130 Thr Pro Val Gly Ala Ser Ile Ser Ser Glu Val Pro Leu Pro Met 2135 2140 2145 Ala Ile Thr Ser Arg Ser Asp Val Ser Gly Leu Thr Ser Glu Ser 2150 2155 2160 Thr Ala Asn Pro Ser Leu Gly Thr Ala Ser Ser Ala Gly Thr Lys 2165 2170 2175 Leu Thr Arg Thr Ile Ser Leu Pro Thr Ser Glu Ser Leu Val Ser 2180 2185 2190 Phe Arg Met Asn Lys Asp Pro Trp Thr Val Ser Ile Pro Leu Gly 2195 2200 2205 Ser His Pro Thr Thr Asn Thr Glu Thr Ser Ile Pro Val Asn Ser 2210 2215 2220 Ala Gly Pro Pro Gly Leu Ser Thr Val Ala Ser Asp Val Ile Asp 2225 2230 2235 Thr Pro Ser Asp Gly Ala Glu Ser Ile Pro Thr Val Ser Phe Ser 2240 2245 2250 Pro Ser Pro Asp Thr Glu Val Thr Thr Ile Ser His Phe Pro Glu 2255 2260 2265 Lys Thr Thr His Ser Phe Arg Thr Ile Ser Ser Leu Thr His Glu 2270 2275 2280 Leu Thr Ser Arg Val Thr Pro Ile Pro Gly Asp Trp Met Ser Ser 2285 2290 2295 Ala Met Ser Thr Lys Pro Thr Gly Ala Ser Pro Ser Ile Thr Leu 2300 2305 2310 Gly Glu Arg Arg Thr Ile Thr Ser Ala Ala Pro Thr Thr Ser Pro 2315 2320 2325 Ile Val Leu Thr Ala Ser Phe Thr Glu Thr Ser Thr Val Ser Leu 2330 2335 2340 Asp Asn Glu Thr Thr Val Lys Thr Ser Asp Ile Leu Asp Ala Arg 2345 2350 2355 Lys Thr Asn Glu Leu Pro Ser Asp Ser Ser Ser Ser Ser Asp Leu 2360 2365 2370 Ile Asn Thr Ser Ile Ala Ser Ser Thr Met Asp Val Thr Lys Thr 2375 2380 2385 Ala Ser Ile Ser Pro Thr Ser Ile Ser Gly Met Thr Ala Ser Ser 2390 2395 2400 Ser Pro Ser Leu Phe Ser Ser Asp Arg Pro Gln Val Pro Thr Ser 2405 2410 2415 Thr Thr Glu Thr Asn Thr Ala Thr Ser Pro Ser Val Ser Ser Asn 2420 2425 2430 Thr Tyr Ser Leu Asp Gly Gly Ser Asn Val Gly Gly Thr Pro Ser 2435 2440 2445 Thr Leu Pro Pro Phe Thr Ile Thr His Pro Val Glu Thr Ser Ser 2450 2455 2460 Ala Leu Leu Ala Trp Ser Arg Pro Val Arg Thr Phe Ser Thr Met 2465 2470 2475 Val Ser Thr Asp Thr Ala Ser Gly Glu Asn Pro Thr Ser Ser Asn 2480 2485 2490 Ser Val Val Thr Ser Val Pro Ala Pro Gly Thr Trp Ala Ser Val 2495 2500 2505 Gly Ser Thr Thr Asp Leu Pro Ala Met Gly Phe Leu Lys Thr Ser 2510 2515 2520 Pro Ala Gly Glu Ala His Ser Leu Leu Ala Ser Thr Ile Glu Pro 2525 2530 2535 Ala Thr Ala Phe Thr Pro His Leu Ser Ala Ala Val Val Thr Gly 2540 2545 2550 Ser Ser Ala Thr Ser Glu Ala Ser Leu Leu Thr Thr Ser Glu Ser 2555 2560 2565 Lys Ala Ile His Ser Ser Pro Gln Thr Pro Thr Thr Pro Thr Ser 2570 2575 2580 Gly Ala Asn Trp Glu Thr Ser Ala Thr Pro Glu Ser Leu Leu Val 2585 2590 2595 Val Thr Glu Thr Ser Asp Thr Thr Leu Thr Ser Lys Ile Leu Val 2600 2605 2610 Thr Asp Thr Ile Leu Phe Ser Thr Val Ser Thr Pro Pro Ser Lys 2615 2620 2625 Phe Pro Ser Thr Gly Thr Leu Ser Gly Ala Ser Phe Pro Thr Leu 2630 2635 2640 Leu Pro Asp Thr Pro Ala Ile Pro Leu Thr Ala Thr Glu Pro Thr 2645 2650 2655 Ser Ser Leu Ala Thr Ser Phe Asp Ser Thr Pro Leu Val Thr Ile 2660 2665 2670 Ala Ser Asp Ser Leu Gly Thr Val Pro Glu Thr Thr Leu Thr Met 2675 2680 2685 Ser Glu Thr Ser Asn Gly Asp Ala Leu Val Leu Lys Thr Val Ser 2690 2695 2700 Asn Pro Asp Arg Ser Ile Pro Gly Ile Thr Ile Gln Gly Val Thr 2705 2710 2715 Glu Ser Pro Leu His Pro Ser Ser Thr Ser Pro Ser Lys Ile Val 2720 2725 2730 Ala Pro Arg Asn Thr Thr Tyr Glu Gly Ser Ile Thr Val Ala Leu 2735 2740 2745 Ser Thr Leu Pro Ala Gly Thr Thr Gly Ser Leu Val Phe Ser Gln 2750 2755 2760 Ser Ser Glu Asn Ser Glu Thr Thr Ala Leu Val Asp Ser Ser Ala 2765 2770 2775 Gly Leu Glu Arg Ala Ser Val Met Pro Leu Thr Thr Gly Ser Gln 2780 2785 2790 Gly Met Ala Ser Ser Gly Gly Ile Arg Ser Gly Ser Thr His Ser 2795 2800 2805 Thr Gly Thr Lys Thr Phe Ser Ser Leu Pro Leu Thr Met Asn Pro 2810 2815 2820 Gly Glu Val Thr Ala Met Ser Glu Ile Thr Thr Asn Arg Leu Thr 2825 2830 2835 Ala Thr Gln Ser Thr Ala Pro Lys Gly Ile Pro Val Lys Pro Thr 2840 2845 2850 Ser Ala Glu Ser Gly Leu Leu Thr Pro Val Ser Ala Ser Ser Ser 2855 2860 2865 Pro Ser Lys Ala Phe Ala Ser Leu Thr Thr Ala Pro Pro Ser Thr 2870 2875 2880 Trp Gly Ile Pro Gln Ser Thr Leu Thr Phe Glu Phe Ser Glu Val 2885 2890 2895 Pro Ser Leu Asp Thr Lys Ser Ala Ser Leu Pro Thr Pro Gly Gln 2900 2905 2910 Ser Leu Asn Thr Ile Pro Asp Ser Asp Ala Ser Thr Ala Ser Ser 2915 2920 2925 Ser Leu Ser Lys Ser Pro Glu Lys Asn Pro Arg Ala Arg Met Met 2930 2935 2940 Thr Ser Thr Lys Ala Ile Ser Ala Ser Ser Phe Gln Ser Thr Gly 2945 2950 2955 Phe Thr Glu Thr Pro Glu Gly Ser Ala Ser Pro Ser Met Ala Gly 2960 2965 2970 His Glu Pro Arg Val Pro Thr Ser Gly Thr Gly Asp Pro Arg Tyr 2975 2980 2985 Ala Ser Glu Ser Met Ser Tyr Pro Asp Pro Ser Lys Ala Ser Ser 2990 2995 3000 Ala Met Thr Ser Thr Ser Leu Ala Ser Lys Leu Thr Thr Leu Phe 3005 3010 3015 Ser Thr Gly Gln Ala Ala Arg Ser Gly Ser Ser Ser Ser Pro Ile 3020 3025 3030 Ser Leu Ser Thr Glu Lys Glu Thr Ser Phe Leu Ser Pro Thr Ala 3035 3040 3045 Ser Thr Ser Arg Lys Thr Ser Leu Phe Leu Gly Pro Ser Met Ala 3050 3055 3060 Arg Gln Pro Asn Ile Leu Val His Leu Gln Thr Ser Ala Leu Thr 3065 3070 3075 Leu Ser Pro Thr Ser Thr Leu Asn Met Ser Gln Glu Glu Pro Pro 3080 3085 3090 Glu Leu Thr Ser Ser Gln Thr Ile Ala Glu Glu Glu Gly Thr Thr 3095 3100 3105 Ala Glu Thr Gln Thr Leu Thr Phe Thr Pro Ser Glu Thr Pro Thr 3110 3115 3120 Ser Leu Leu Pro Val Ser Ser Pro Thr Glu Pro Thr Ala Arg Arg 3125 3130 3135 Lys Ser Ser Pro Glu Thr Trp Ala Ser Ser Ile Ser Val Pro Ala 3140 3145 3150 Lys Thr Ser Leu Val Glu Thr Thr Asp Gly Thr Leu Val Thr Thr 3155 3160 3165 Ile Lys Met Ser Ser Gln Ala Ala Gln Gly Asn Ser Thr Trp Pro 3170 3175 3180 Ala Pro Ala Glu Glu Thr Gly Thr Ser Pro Ala Gly Thr Ser Pro 3185 3190 3195 Gly Ser Pro Glu Val Ser Thr Thr Leu Lys Ile Met Ser Ser Lys 3200 3205 3210 Glu Pro Ser Ile Ser Pro Glu Ile Arg Ser Thr Val Arg Asn Ser 3215 3220 3225 Pro Trp Lys Thr Pro Glu Thr Thr Val Pro Met Glu Thr Thr Val 3230 3235 3240 Glu Pro Val Thr Leu Gln Ser Thr Ala Leu Gly Ser Gly Ser Thr 3245 3250 3255 Ser Ile Ser His Leu Pro Thr Gly Thr Thr Ser Pro Thr Lys Ser 3260 3265 3270 Pro Thr Glu Asn Met Leu Ala Thr Glu Arg Val Ser Leu Ser Pro 3275 3280 3285 Ser Pro Pro Glu Ala Trp Thr Asn Leu Tyr Ser Gly Thr Pro Gly 3290 3295 3300 Gly Thr Arg Gln Ser Leu Ala Thr Met Ser Ser Val Ser Leu Glu 3305 3310 3315 Ser Pro Thr Ala Arg Ser Ile Thr Gly Thr Gly Gln Gln Ser Ser 3320 3325 3330 Pro Glu Leu Val Ser Lys Thr Thr Gly Met Glu Phe Ser Met Trp 3335 3340 3345 His Gly Ser Thr Gly Gly Thr Thr Gly Asp Thr His Val Ser Leu 3350 3355 3360 Ser Thr Ser Ser Asn Ile Leu Glu Asp Pro Val Thr Ser Pro Asn 3365 3370 3375 Ser Val Ser Ser Leu Thr Asp Lys Ser Lys His Lys Thr Glu Thr 3380 3385 3390 Trp Val Ser Thr Thr Ala Ile Pro Ser Thr Val Leu Asn Asn Lys 3395 3400 3405 Ile Met Ala Ala Glu Gln Gln Thr Ser Arg Ser Val Asp Glu Ala 3410 3415 3420 Tyr Ser Ser Thr Ser Ser Trp Ser Asp Gln Thr Ser Gly Ser Asp 3425 3430 3435 Ile Thr Leu Gly Ala Ser Pro Asp Val Thr Asn Thr Leu Tyr Ile 3440 3445 3450 Thr Ser Thr Ala Gln Thr Thr Ser Leu Val Ser Leu Pro Ser Gly 3455 3460 3465 Asp Gln Gly Ile Thr Ser Leu Thr Asn Pro Ser Gly Gly Lys Thr 3470 3475 3480 Ser Ser Ala Ser Ser Val Thr Ser Pro Ser Ile Gly Leu Glu Thr 3485 3490 3495 Leu Arg Ala Asn Val Ser Ala Val Lys Ser Asp Ile Ala Pro Thr 3500 3505 3510 Ala Gly His Leu Ser Gln Thr Ser Ser Pro Ala Glu Val Ser Ile 3515 3520 3525 Leu Asp Val Thr Thr Ala Pro Thr Pro Gly Ile Ser Thr Thr Ile 3530 3535 3540 Thr Thr Met Gly Thr Asn Ser Ile Ser Thr Thr Thr Pro Asn Pro 3545 3550 3555 Glu Val Gly Met Ser Thr Met Asp Ser Thr Pro Ala Thr Glu Arg 3560 3565 3570 Arg Thr Thr Ser Thr Glu His Pro Ser Thr Trp Ser Ser Thr Ala 3575 3580 3585 Ala Ser Asp Ser Trp Thr Val Thr Asp Met Thr Ser Asn Leu Lys 3590 3595 3600 Val Ala Arg Ser Pro Gly Thr Ile Ser Thr Met His Thr Thr Ser 3605 3610 3615 Phe Leu Ala Ser Ser Thr Glu Leu Asp Ser Met Ser Thr Pro His 3620 3625 3630 Gly Arg Ile Thr Val Ile Gly Thr Ser Leu Val Thr Pro Ser Ser 3635 3640 3645 Asp Ala Ser Ala Val Lys Thr Glu Thr Ser Thr Ser Glu Arg Thr 3650 3655 3660 Leu Ser Pro Ser Asp Thr Thr Ala Ser Thr Pro Ile Ser Thr Phe 3665 3670 3675 Ser Arg Val Gln Arg Met Ser Ile Ser Val Pro Asp Ile Leu Ser 3680 3685 3690 Thr Ser Trp Thr Pro Ser Ser Thr Glu Ala Glu Asp Val Pro Val 3695 3700 3705 Ser Met Val Pro Thr Asp His Ala Ser Thr Lys Thr Asp Pro Asn 3710 3715 3720 Thr Pro Leu Ser Thr Phe Leu Phe Asp Ser Leu Ser Thr Leu Asp 3725 3730 3735 Trp Asp Thr Gly Arg Ser Leu Ser Ser Ala Thr Ala Thr Thr Ser 3740 3745 3750 Ala Pro Gln Gly Ala Thr Thr Pro Gln Glu Leu Thr Leu Glu Thr 3755 3760 3765 Met Ile Ser Pro Ala Thr Ser Gln Leu Pro Phe Ser Ile Gly His 3770 3775 3780 Ile Thr Ser Ala Val Thr Pro Ala Ala Met Ala Arg Ser Ser Gly 3785 3790 3795 Val Thr Phe Ser Arg Pro Asp Pro Thr Ser Lys Lys Ala Glu Gln 3800 3805 3810 Thr Ser Thr Gln Leu Pro Thr Thr Thr Ser Ala His Pro Gly Gln 3815 3820 3825 Val Pro Arg Ser Ala Ala Thr Thr Leu Asp Val Ile Pro His Thr 3830 3835 3840 Ala Lys Thr Pro Asp Ala Thr Phe Gln Arg Gln Gly Gln Thr Ala 3845 3850 3855 Leu Thr Thr Glu Ala Arg Ala Thr Ser Asp Ser Trp Asn Glu Lys 3860 3865 3870 Glu Lys Ser Thr Pro Ser Ala Pro Trp Ile Thr Glu Met Met Asn 3875 3880 3885 Ser Val Ser Glu Asp Thr Ile Lys Glu Val Thr Ser Ser Ser Ser 3890 3895 3900 Val Leu Lys Asp Pro Glu Tyr Ala Gly His Lys Leu Gly Ile Trp 3905 3910 3915 Asp Asp Phe Ile Pro Lys Phe Gly Lys Ala Ala His Met Arg Glu 3920 3925 3930 Leu Pro Leu Leu Ser Pro Pro Gln Asp Lys Glu Ala Ile His Pro 3935 3940 3945 Ser Thr Asn Thr Val Glu Thr Thr Gly Trp Val Thr Ser Ser Glu 3950 3955 3960 His Ala Ser His Ser Thr Ile Pro Ala His Ser Ala Ser Ser Lys 3965 3970 3975 Leu Thr Ser Pro Val Val Thr Thr Ser Thr Arg Glu Gln Ala Ile 3980 3985 3990 Val Ser Met Ser Thr Thr Thr Trp Pro Glu Ser Thr Arg Ala Arg 3995 4000 4005 Thr Glu Pro Asn Ser Phe Leu Thr Ile Glu Leu Arg Asp Val Ser 4010 4015 4020 Pro Tyr Met Asp Thr Ser Ser Thr Thr Gln Thr Ser Ile Ile Ser 4025 4030 4035 Ser Pro Gly Ser Thr Ala Ile Thr Lys Gly His Arg Thr Glu Ile 4040 4045 4050 Thr Ser Tyr Lys Arg Ile Ser Ser Ser Phe Leu Ala Gln Ser Met 4055 4060 4065 Arg Ser Ser Asp Ser Pro Ser Glu Ala Ile Thr Arg Leu Ser Asn 4070 4075 4080 Phe Pro Ala Met Thr Glu Ser Gly Gly Met Ile Leu Ala Met Gln 4085 4090 4095 Thr Ser Pro Pro Gly Ala Thr Ser Ile Ser Ala Pro Thr Leu Asp 4100 4105 4110 Thr Ser Ala Thr Ala Ser Trp Thr Gly Thr Pro Leu Ala Thr Thr 4115 4120 4125 Gln Arg Phe Thr Tyr Ser Glu Lys Thr Thr Leu Phe Ser Lys Gly 4130 4135 4140 Arg Glu Asp Thr Ser Gln Pro Ser Pro Pro Cys Val Glu Glu Thr 4145 4150 4155 Ser Ser Ser Ser Ser Val Val Pro Ile His Ala Thr Thr Ser Pro 4160 4165 4170 Ser Asn Ile Leu Leu Thr Ser Gln Gly His Ser Pro Ser Ser Thr 4175 4180 4185 Pro Pro Val Thr Ser Val Phe Leu Ser Glu Thr Ser Gly Leu Gly 4190 4195 4200 Lys Thr Thr Asp Met Ser Arg Ile Ser Leu Glu Pro Gly Thr Ser 4205 4210 4215 Leu Pro Pro Asn Leu Ser Ser Thr Ala Gly Glu Ala Leu Ser Thr 4220 4225 4230 Tyr Glu Ala Ser Arg Asp Thr Lys Ala Ile His His Ser Ala Asp 4235 4240 4245 Thr Ala Val Thr Asn Met Glu Ala Thr Ser Ser Glu Tyr Ser Pro 4250 4255 4260 Ile Pro Gly His Thr Lys Pro Ser Lys Ala Thr Ser Pro Leu Val 4265 4270 4275 Thr Ser His Ile Met Gly Asp Ile Thr Ser Ser Thr Ser Val Phe 4280 4285 4290 Gly Ser Ser Glu Thr Thr Glu Ile Glu Thr Val Ser Ser Val Asn 4295 4300 4305 Gln Gly Leu Gln Glu Arg Ser Thr Ser Gln Val Ala Ser Ser Ala 4310 4315 4320 Thr Glu Thr Ser Thr Val Ile Thr His Val Ser Ser Gly Asp Ala 4325 4330 4335 Thr Thr His Val Thr Lys Thr Gln Ala Thr Phe Ser Ser Gly Thr 4340 4345 4350 Ser Ile Ser Ser Pro His Gln Phe Ile Thr Ser Thr Asn Thr Phe 4355 4360 4365 Thr Asp Val Ser Thr Asn Pro Ser Thr Ser Leu Ile Met Thr Glu 4370 4375 4380 Ser Ser Gly Val Thr Ile Thr Thr Gln Thr Gly Pro Thr Gly Ala 4385 4390 4395 Ala Thr Gln Gly Pro Tyr Leu Leu Asp Thr Ser Thr Met Pro Tyr 4400 4405 4410 Leu Thr Glu Thr Pro Leu Ala Val Thr Pro Asp Phe Met Gln Ser 4415 4420 4425 Glu Lys Thr Thr Leu Ile Ser Lys Gly Pro Lys Asp Val Thr Trp 4430 4435 4440 Thr Ser Pro Pro Ser Val Ala Glu Thr Ser Tyr Pro Ser Ser Leu 4445 4450 4455 Thr Pro Phe Leu Val Thr Thr Ile Pro Pro Ala Thr Ser Thr Leu 4460 4465 4470 Gln Gly Gln His Thr Ser Ser Pro Val Ser Ala Thr Ser Val Leu 4475 4480 4485 Thr Ser Gly Leu Val Lys Thr Thr Asp Met Leu Asn Thr Ser Met 4490 4495 4500 Glu Pro Val Thr Asn Ser Pro Gln Asn Leu Asn Asn Pro Ser Asn 4505 4510 4515 Glu Ile Leu Ala Thr Leu Ala Ala Thr Thr Asp Ile Glu Thr Ile 4520 4525 4530 His Pro Ser Ile Asn Lys Ala Val Thr Asn Met Gly Thr Ala Ser 4535 4540 4545 Ser Ala His Val Leu His Ser Thr Leu Pro Val Ser Ser Glu Pro 4550 4555 4560 Ser Thr Ala Thr Ser Pro Met Val Pro Ala Ser Ser Met Gly Asp 4565 4570 4575 Ala Leu Ala Ser Ile Ser Ile Pro Gly Ser Glu Thr Thr Asp Ile 4580 4585 4590 Glu Gly Glu Pro Thr Ser Ser Leu Thr Ala Gly Arg Lys Glu Asn 4595 4600 4605 Ser Thr Leu Gln Glu Met Asn Ser Thr Thr Glu Ser Asn Ile Ile 4610 4615 4620 Leu Ser Asn Val Ser Val Gly Ala Ile Thr Glu Ala Thr Lys Met 4625 4630 4635 Glu Val Pro Ser Phe Asp Ala Thr Phe Ile Pro Thr Pro Ala Gln 4640 4645 4650 Ser Thr Lys Phe Pro Asp Ile Phe Ser Val Ala Ser Ser Arg Leu 4655 4660 4665 Ser Asn Ser Pro Pro Met Thr Ile Ser Thr His Met Thr Thr Thr 4670 4675 4680 Gln Thr Gly Ser Ser Gly Ala Thr Ser Lys Ile Pro Leu Ala Leu 4685 4690 4695 Asp Thr Ser Thr Leu Glu Thr Ser Ala Gly Thr Pro Ser Val Val 4700 4705 4710 Thr Glu Gly Phe Ala His Ser Lys Ile Thr Thr Ala Met Asn Asn 4715 4720 4725 Asp Val Lys Asp Val Ser Gln Thr Asn Pro Pro Phe Gln Asp Glu 4730 4735 4740 Ala Ser Ser Pro Ser Ser Gln Ala Pro Val Leu Val Thr Thr Leu 4745 4750 4755 Pro Ser Ser Val Ala Phe Thr Pro Gln Trp His Ser Thr Ser Ser 4760 4765 4770 Pro Val Ser Met Ser Ser Val Leu Thr Ser Ser Leu Val Lys Thr 4775 4780 4785 Ala Gly Lys Val Asp Thr Ser Leu Glu Thr Val Thr Ser Ser Pro 4790 4795 4800 Gln Ser Met Ser Asn Thr Leu Asp Asp Ile Ser Val Thr Ser Ala 4805 4810 4815 Ala Thr Thr Asp Ile Glu Thr Thr His Pro Ser Ile Asn Thr Val 4820 4825 4830 Val Thr Asn Val Gly Thr Thr Gly Ser Ala Phe Glu Ser His Ser 4835 4840 4845 Thr Val Ser Ala Tyr Pro Glu Pro Ser Lys Val Thr Ser Pro Asn 4850 4855 4860 Val Thr Thr Ser Thr Met Glu Asp Thr Thr Ile Ser Arg Ser Ile 4865 4870 4875 Pro Lys Ser Ser Lys Thr Thr Arg Thr Glu Thr Glu Thr Thr Ser 4880 4885 4890 Ser Leu Thr Pro Lys Leu Arg Glu Thr Ser Ile Ser Gln Glu Ile 4895 4900 4905 Thr Ser Ser Thr Glu Thr Ser Thr Val Pro Tyr Lys Glu Leu Thr 4910 4915 4920 Gly Ala Thr Thr Glu Val Ser Arg Thr Asp Val Thr Ser Ser Ser 4925 4930 4935 Ser Thr Ser Phe Pro Gly Pro Asp Gln Ser Thr Val Ser Leu Asp 4940 4945 4950 Ile Ser Thr Glu Thr Asn Thr Arg Leu Ser Thr Ser Pro Ile Met 4955 4960 4965 Thr Glu Ser Ala Glu Ile Thr Ile Thr Thr Gln Thr Gly Pro His 4970 4975 4980 Gly Ala Thr Ser Gln Asp Thr Phe Thr Met Asp Pro Ser Asn Thr 4985 4990 4995 Thr Pro Gln Ala Gly Ile His Ser Ala Met Thr His Gly Phe Ser 5000 5005 5010 Gln Leu Asp Val Thr Thr Leu Met Ser Arg Ile Pro Gln Asp Val 5015 5020 5025 Ser Trp Thr Ser Pro Pro Ser Val Asp Lys Thr Ser Ser Pro Ser 5030 5035 5040 Ser Phe Leu Ser Ser Pro Ala Met Thr Thr Pro Ser Leu Ile Ser 5045 5050 5055 Ser Thr Leu Pro Glu Asp Lys Leu Ser Ser Pro Met Thr Ser Leu 5060 5065 5070 Leu Thr Ser Gly Leu Val Lys Ile Thr Asp Ile Leu Arg Thr Arg 5075 5080 5085 Leu Glu Pro Val Thr Ser Ser Leu Pro Asn Phe Ser Ser Thr Ser 5090 5095 5100 Asp Lys Ile Leu Ala Thr Ser Lys Asp Ser Lys Asp Thr Lys Glu 5105 5110 5115 Ile Phe Pro Ser Ile Asn Thr Glu Glu Thr Asn Val Lys Ala Asn 5120 5125 5130 Asn Ser Gly His Glu Ser His Ser Pro Ala Leu Ala Asp Ser Glu 5135 5140 5145 Thr Pro Lys Ala Thr Thr Gln Met Val Ile Thr Thr Thr Val Gly 5150 5155 5160 Asp Pro Ala Pro Ser Thr Ser Met Pro Val His Gly Ser Ser Glu 5165 5170 5175 Thr Thr Asn Ile Lys Arg Glu Pro Thr Tyr Phe Leu Thr Pro Arg 5180 5185 5190 Leu Arg Glu Thr Ser Thr Ser Gln Glu Ser Ser Phe Pro Thr Asp 5195 5200 5205 Thr Ser Phe Leu Leu Ser Lys Val Pro Thr Gly Thr Ile Thr Glu 5210 5215 5220 Val Ser Ser Thr Gly Val Ile Ser Ser Ser Lys Ile Ser Thr Pro 5225 5230 5235 Asp His Asp Lys Ser Thr Val Pro Pro Asp Thr Phe Thr Gly Glu 5240 5245 5250 Ile Pro Arg Val Phe Thr Ser Ser Ile Lys Thr Lys Ser Ala Glu 5255 5260 5265 Met Thr Ile Thr Thr Gln Ala Ser Pro Pro Glu Ser Ala Ser His 5270 5275 5280 Ser Thr Leu Pro Leu Asp Thr Ser Thr Thr Leu Ser Gln Gly Gly 5285 5290 5295 Thr His Ser Thr Val Ser Gln Gly Phe Pro Tyr Ser Glu Val Thr 5300 5305 5310 Thr Leu Met Gly Met Gly Pro Gly Asn Val Ser Trp Met Thr Thr 5315 5320 5325 Pro Pro Val Glu Glu Thr Ser Ser Val Ser Ser Leu Met Ser Ser 5330 5335 5340 Pro Ala Met Thr Ser Pro Ser Pro Val Ser Ser Thr Ser Pro Gln 5345 5350 5355 Ser Ile Pro Ser Ser Pro Leu Pro Val Thr Ala Leu Pro Thr Ser 5360 5365 5370 Val Leu Val Thr Thr Thr Asp Val Leu Gly Thr Thr Ser Pro Glu 5375 5380 5385 Ser Val Thr Ser Ser Pro Pro Asn Leu Ser Ser Ile Thr His Glu 5390 5395 5400 Arg Pro Ala Thr Tyr Lys Asp Thr Ala His Thr Glu Ala Ala Met 5405 5410 5415 His His Ser Thr Asn Thr Ala Val Thr Asn Val Gly Thr Ser Gly 5420 5425 5430 Ser Gly His Lys Ser Gln Ser Ser Val Leu Ala Asp Ser Glu Thr 5435 5440 5445 Ser Lys Ala Thr Pro Leu Met Ser Thr Ala Ser Thr Leu Gly Asp 5450 5455 5460 Thr Ser Val Ser Thr Ser Thr Pro Asn Ile Ser Gln Thr Asn Gln 5465 5470 5475 Ile Gln Thr Glu Pro Thr Ala Ser Leu Ser Pro Arg Leu Arg Glu 5480 5485 5490 Ser Ser Thr Ser Glu Lys Thr Ser Ser Thr Thr Glu Thr Asn Thr 5495 5500 5505 Ala Phe Ser Tyr Val Pro Thr Gly Ala Ile Thr Gln Ala Ser Arg 5510 5515 5520 Thr Glu Ile Ser Ser Ser Arg Thr Ser Ile Ser Asp Leu Asp Arg 5525 5530 5535 Ser Thr Ile Ala Pro Asp Ile Ser Thr Gly Met Ile Thr Arg Leu 5540 5545 5550 Phe Thr Ser Pro Ile Met Thr Lys Ser Ala Glu Met Thr Val Thr 5555 5560 5565 Thr Gln Thr Thr Thr Pro Gly Ala Thr Ser Gln Gly Ile Leu Pro 5570 5575 5580 Trp Asp Thr Ser Thr Thr Leu Phe Gln Gly Gly Thr His Ser Thr 5585 5590 5595 Val Ser Gln Gly Phe Pro His Ser Glu Ile Thr Thr Leu Arg Ser 5600 5605 5610 Arg Thr Pro Gly Asp Val Ser Trp Met Thr Thr Pro Pro Val Glu 5615 5620 5625 Glu Thr Ser Ser Gly Phe Ser Leu Met Ser Pro Ser Met Thr Ser 5630 5635 5640 Pro Ser Pro Val Ser Ser Thr Ser Pro Glu Ser Ile Pro Ser Ser 5645 5650 5655 Pro Leu Pro Val Thr Ala Leu Leu Thr Ser Val Leu Val Thr Thr 5660 5665 5670 Thr Asn Val Leu Gly Thr Thr Ser Pro Glu Pro Val Thr Ser Ser 5675 5680 5685 Pro Pro Asn Leu Ser Ser Pro Thr Gln Glu Arg Leu Thr Thr Tyr 5690 5695 5700 Lys Asp Thr Ala His Thr Glu Ala Met His Ala Ser Met His Thr 5705 5710 5715 Asn Thr Ala Val Ala Asn Val Gly Thr Ser Ile Ser Gly His Glu 5720 5725 5730 Ser Gln Ser Ser Val Pro Ala Asp Ser His Thr Ser Lys Ala Thr 5735 5740 5745 Ser Pro Met Gly Ile Thr Phe Ala Met Gly Asp Thr Ser Val Tyr 5750 5755 5760 Thr Ser Thr Pro Ala Phe Phe Glu Thr Arg Ile Gln Ser Glu Ser 5765 5770 5775 Thr Ser Ser Leu Ile Pro Gly Leu Arg Asp Thr Arg Thr Ser Glu 5780 5785 5790 Glu Ile Asn Thr Val Thr Glu Thr Ser Thr Val Leu Ser Glu Val 5795 5800 5805 Pro Thr Thr Thr Thr Thr Glu Val Ser Arg Thr Glu Val Ile Thr 5810 5815 5820 Ser Ser Arg Thr Thr Ile Ser Gly Pro Asp His Ser Lys Met Ser 5825 5830 5835 Pro Tyr Ile Ser Thr Glu Thr Ile Thr Arg Leu Ser Thr Phe Pro 5840 5845 5850 Phe Val Thr Gly Ser Thr Glu Met Ala Ile Thr Asn Gln Thr Gly 5855 5860 5865 Pro Ile Gly Thr Ile Ser Gln Ala Thr Leu Thr Leu Asp Thr Ser 5870 5875 5880 Ser Thr Ala Ser Trp Glu Gly Thr His Ser Pro Val Thr Gln Arg 5885 5890 5895 Phe Pro His Ser Glu Glu Thr Thr Thr Met Ser Arg Ser Thr Lys 5900 5905 5910 Gly Val Ser Trp Gln Ser Pro Pro Ser Val Glu Glu Thr Ser Ser 5915 5920 5925 Pro Ser Ser Pro Val Pro Leu Pro Ala Ile Thr Ser His Ser Ser 5930 5935 5940 Leu Tyr Ser Ala Val Ser Gly Ser Ser Pro Thr Ser Ala Leu Pro 5945 5950 5955 Val Thr Ser Leu Leu Thr Ser Gly Arg Arg Lys Thr Ile Asp Met 5960 5965 5970 Leu Asp Thr His Ser Glu Leu Val Thr Ser Ser Leu Pro Ser Ala 5975 5980 5985 Ser Ser Phe Ser Gly Glu Ile Leu Thr Ser Glu Ala Ser Thr Asn 5990 5995 6000 Thr Glu Thr Ile His Phe Ser Glu Asn Thr Ala Glu Thr Asn Met 6005 6010 6015 Gly Thr Thr Asn Ser Met His Lys Leu His Ser Ser Val Ser Ile 6020 6025 6030 His Ser Gln Pro Ser Gly His Thr Pro Pro Lys Val Thr Gly Ser 6035 6040 6045 Met Met Glu Asp Ala Ile Val Ser Thr Ser Thr Pro Gly Ser Pro 6050 6055 6060 Glu Thr Lys Asn Val Asp Arg Asp Ser Thr Ser Pro Leu Thr Pro 6065 6070 6075 Glu Leu Lys Glu Asp Ser Thr Ala Leu Val Met Asn Ser Thr Thr 6080 6085 6090 Glu Ser Asn Thr Val Phe Ser Ser Val Ser Leu Asp Ala Ala Thr 6095 6100 6105 Glu Val Ser Arg Ala Glu Val Thr Tyr Tyr Asp Pro Thr Phe Met 6110 6115 6120 Pro Ala Ser Ala Gln Ser Thr Lys Ser Pro Asp Ile Ser Pro Glu 6125 6130 6135 Ala Ser Ser Ser His Ser Asn Ser Pro Pro Leu Thr Ile Ser Thr 6140 6145 6150 His Lys Thr Ile Ala Thr Gln Thr Gly Pro Ser Gly Val Thr Ser 6155 6160 6165 Leu Gly Gln Leu Thr Leu Asp Thr Ser Thr Ile Ala Thr Ser Ala 6170 6175 6180 Gly Thr Pro Ser Ala Arg Thr Gln Asp Phe Val Asp Ser Glu Thr 6185 6190 6195 Thr Ser Val Met Asn Asn Asp Leu Asn Asp Val Leu Lys Thr Ser 6200 6205 6210 Pro Phe Ser Ala Glu Glu Ala Asn Ser Leu Ser Ser Gln Ala Pro 6215 6220 6225 Leu Leu Val Thr Thr Ser Pro Ser Pro Val Thr Ser Thr Leu Gln 6230 6235 6240 Glu His Ser Thr Ser Ser Leu Val Ser Val Thr Ser Val Pro Thr 6245 6250 6255 Pro Thr Leu Ala Lys Ile Thr Asp Met Asp Thr Asn Leu Glu Pro 6260 6265 6270 Val Thr Arg Ser Pro Gln Asn Leu Arg Asn Thr Leu Ala Thr Ser 6275 6280 6285 Glu Ala Thr Thr Asp Thr His Thr Met His Pro Ser Ile Asn Thr 6290 6295 6300 Ala Met Ala Asn Val Gly Thr Thr Ser Ser Pro Asn Glu Phe Tyr 6305 6310 6315 Phe Thr Val Ser Pro Asp Ser Asp Pro Tyr Lys Ala Thr Ser Ala 6320 6325 6330 Val Val Ile Thr Ser Thr Ser Gly Asp Ser Ile Val Ser Thr Ser 6335 6340 6345 Met Pro Arg Ser Ser Ala Met Lys Lys Ile Glu Ser Glu Thr Thr 6350 6355 6360 Phe Ser Leu Ile Phe Arg Leu Arg Glu Thr Ser Thr Ser Gln Lys 6365 6370 6375 Ile Gly Ser Ser Ser Asp Thr Ser Thr Val Phe Asp Lys Ala Phe 6380 6385 6390 Thr Ala Ala Thr Thr Glu Val Ser Arg Thr Glu Leu Thr Ser Ser 6395 6400 6405 Ser Arg Thr Ser Ile Gln Gly Thr Glu Lys Pro Thr Met Ser Pro 6410 6415 6420 Asp Thr Ser Thr Arg Ser Val Thr Met Leu Ser Thr Phe Ala Gly 6425 6430 6435 Leu Thr Lys Ser Glu Glu Arg Thr Ile Ala Thr Gln Thr Gly Pro 6440 6445 6450 His Arg Ala Thr Ser Gln Gly Thr Leu Thr Trp Asp Thr Ser Ile 6455 6460 6465 Thr Thr Ser Gln Ala Gly Thr His Ser Ala Met Thr His Gly Phe 6470 6475 6480 Ser Gln Leu Asp Leu Ser Thr Leu Thr Ser Arg Val Pro Glu Tyr 6485 6490 6495 Ile Ser Gly Thr Ser Pro Pro Ser Val Glu Lys Thr Ser Ser Ser 6500 6505 6510 Ser Ser Leu Leu Ser Leu Pro Ala Ile Thr Ser Pro Ser Pro Val 6515 6520 6525 Pro Thr Thr Leu Pro Glu Ser Arg Pro Ser Ser Pro Val His Leu 6530 6535 6540 Thr Ser Leu Pro Thr Ser Gly Leu Val Lys Thr Thr Asp Met Leu 6545 6550 6555 Ala Ser Val Ala Ser Leu Pro Pro Asn Leu Gly Ser Thr Ser His 6560 6565 6570 Lys Ile Pro Thr Thr Ser Glu Asp Ile Lys Asp Thr Glu Lys Met 6575 6580 6585 Tyr Pro Ser Thr Asn Ile Ala Val Thr Asn Val Gly Thr Thr Thr 6590 6595 6600 Ser Glu Lys Glu Ser Tyr Ser Ser Val Pro Ala Tyr Ser Glu Pro 6605 6610 6615 Pro Lys Val Thr Ser Pro Met Val Thr Ser Phe Asn Ile Arg Asp 6620 6625 6630 Thr Ile Val Ser Thr Ser Met Pro Gly Ser Ser Glu Ile Thr Arg 6635 6640 6645 Ile Glu Met Glu Ser Thr Phe Ser Leu Ala His Gly Leu Lys Gly 6650 6655 6660 Thr Ser Thr Ser Gln Asp Pro Ile Val Ser Thr Glu Lys Ser Ala 6665 6670 6675 Val Leu His Lys Leu Thr Thr Gly Ala Thr Glu Thr Ser Arg Thr 6680 6685 6690 Glu Val Ala Ser Ser Arg Arg Thr Ser Ile Pro Gly Pro Asp His 6695 6700 6705 Ser Thr Glu Ser Pro Asp Ile Ser Thr Glu Val Ile Pro Ser Leu 6710 6715 6720 Pro Ile Ser Leu Gly Ile Thr Glu Ser Ser Asn Met Thr Ile Ile 6725 6730 6735 Thr Arg Thr Gly Pro Pro Leu Gly Ser Thr Ser Gln Gly Thr Phe 6740 6745 6750 Thr Leu Asp Thr Pro Thr Thr Ser Ser Arg Ala Gly Thr His Ser 6755 6760 6765 Met Ala Thr Gln Glu Phe Pro His Ser Glu Met Thr Thr Val Met 6770 6775 6780 Asn Lys Asp Pro Glu Ile Leu Ser Trp Thr Ile Pro Pro Ser Ile 6785 6790 6795 Glu Lys Thr Ser Phe Ser Ser Ser Leu Met Pro Ser Pro Ala Met 6800 6805 6810 Thr Ser Pro Pro Val Ser Ser Thr Leu Pro Lys Thr Ile His Thr 6815 6820 6825 Thr Pro Ser Pro Met Thr Ser Leu Leu Thr Pro Ser Leu Val Met 6830 6835 6840 Thr Thr Asp Thr Leu Gly Thr Ser Pro Glu Pro Thr Thr Ser Ser 6845 6850 6855 Pro Pro Asn Leu Ser Ser Thr Ser His Val Ile Leu Thr Thr Asp 6860 6865 6870 Glu Asp Thr Thr Ala Ile Glu Ala Met His Pro Ser Thr Ser Thr 6875 6880 6885 Ala Ala Thr Asn Val Glu Thr Thr Cys Ser Gly His Gly Ser Gln 6890 6895 6900 Ser Ser Val Leu Thr Asp Ser Glu Lys Thr Lys Ala Thr Ala Pro 6905 6910 6915 Met Asp Thr Thr Ser Thr Met Gly His Thr Thr Val Ser Thr Ser 6920 6925 6930 Met Ser Val Ser Ser Glu Thr Thr Lys Ile Lys Arg Glu Ser Thr 6935 6940 6945 Tyr Ser Leu Thr Pro Gly Leu Arg Glu Thr Ser Ile Ser Gln Asn 6950 6955 6960 Ala Ser Phe Ser Thr Asp Thr Ser Ile Val Leu Ser Glu Val Pro 6965 6970 6975 Thr Gly Thr Thr Ala Glu Val Ser Arg Thr Glu Val Thr Ser Ser 6980 6985 6990 Gly Arg Thr Ser Ile Pro Gly Pro Ser Gln Ser Thr Val Leu Pro 6995 7000 7005 Glu Ile Ser Thr Arg Thr Met Thr Arg Leu Phe Ala Ser Pro Thr 7010 7015 7020 Met Thr Glu Ser Ala Glu Met Thr Ile Pro Thr Gln Thr Gly Pro 7025 7030 7035 Ser Gly Ser Thr Ser Gln Asp Thr Leu Thr Leu Asp Thr Ser Thr 7040 7045 7050 Thr Lys Ser Gln Ala Lys Thr His Ser Thr Leu Thr Gln Arg Phe 7055 7060 7065 Pro His Ser Glu Met Thr Thr Leu Met Ser Arg Gly Pro Gly Asp 7070 7075 7080 Met Ser Trp Gln Ser Ser Pro Ser Leu Glu Asn Pro Ser Ser Leu 7085 7090 7095 Pro Ser Leu Leu Ser Leu Pro Ala Thr Thr Ser Pro Pro Pro Ile 7100 7105 7110 Ser Ser Thr Leu Pro Val Thr Ile Ser Ser Ser Pro Leu Pro Val 7115 7120 7125 Thr Ser Leu Leu Thr Ser Ser Pro Val Thr Thr Thr Asp Met Leu 7130 7135 7140 His Thr Ser Pro Glu Leu Val Thr Ser Ser Pro Pro Lys Leu Ser 7145 7150 7155 His Thr Ser Asp Glu Arg Leu Thr Thr Gly Lys Asp Thr Thr Asn 7160 7165 7170 Thr Glu Ala Val His Pro Ser Thr Asn Thr Ala Ala Ser Asn Val 7175 7180 7185 Glu Ile Pro Ser Phe Gly His Glu Ser Pro Ser Ser Ala Leu Ala 7190 7195 7200 Asp Ser Glu Thr Ser Lys Ala Thr Ser Pro Met Phe Ile Thr Ser 7205 7210 7215 Thr Gln Glu Asp Thr Thr Val Ala Ile Ser Thr Pro His Phe Leu 7220 7225 7230 Glu Thr Ser Arg Ile Gln Lys Glu Ser Ile Ser Ser Leu Ser Pro 7235 7240 7245 Lys Leu Arg Glu Thr Gly Ser Ser Val Glu Thr Ser Ser Ala Ile 7250 7255 7260 Glu Thr Ser Ala Val Leu Ser Glu Val Ser Ile Gly Ala Thr Thr 7265 7270 7275 Glu Ile Ser Arg Thr Glu Val Thr Ser Ser Ser Arg Thr Ser Ile 7280 7285 7290 Ser Gly Ser Ala Glu Ser Thr Met Leu Pro Glu Ile Ser Thr Thr 7295 7300 7305 Arg Lys Ile Ile Lys Phe Pro Thr Ser Pro Ile Leu Ala Glu Ser 7310 7315 7320 Ser Glu Met Thr Ile Lys Thr Gln Thr Ser Pro Pro Gly Ser Thr 7325 7330 7335 Ser Glu Ser Thr Phe Thr Leu Asp Thr Ser Thr Thr Pro Ser Leu 7340 7345 7350 Val Ile Thr His Ser Thr Met Thr Gln Arg Leu Pro His Ser Glu 7355 7360 7365 Ile Thr Thr Leu Val Ser Arg Gly Ala Gly Asp Val Pro Arg Pro 7370 7375 7380 Ser Ser Leu Pro Val Glu Glu Thr Ser Pro Pro Ser Ser Gln Leu 7385 7390 7395 Ser Leu Ser Ala Met Ile Ser Pro Ser Pro Val Ser Ser Thr Leu 7400 7405 7410 Pro Ala Ser Ser His Ser Ser Ser Ala Ser Val Thr Ser Pro Leu 7415 7420 7425 Thr Pro Gly Gln Val Lys Thr Thr Glu Val Leu Asp Ala Ser Ala 7430 7435 7440 Glu Pro Glu Thr Ser Ser Pro Pro Ser Leu Ser Ser Thr Ser Val 7445 7450 7455 Glu Ile Leu Ala Thr Ser Glu Val Thr Thr Asp Thr Glu Lys Ile 7460 7465 7470 His Pro Phe Pro Asn Thr Ala Val Thr Lys Val Gly Thr Ser Ser 7475 7480 7485 Ser Gly His Glu Ser Pro Ser Ser Val Leu Pro Asp Ser Glu Thr 7490 7495 7500 Thr Lys Ala Thr Ser Ala Met Gly Thr Ile Ser Ile Met Gly Asp 7505 7510 7515 Thr Ser Val Ser Thr Leu Thr Pro Ala Leu Ser Asn Thr Arg Lys 7520 7525 7530 Ile Gln Ser Glu Pro Ala Ser Ser Leu Thr Thr Arg Leu Arg Glu 7535 7540 7545 Thr Ser Thr Ser Glu Glu Thr Ser Leu Ala Thr Glu Ala Asn Thr 7550 7555 7560 Val Leu Ser Lys Val Ser Thr Gly Ala Thr Thr Glu Val Ser Arg 7565 7570 7575 Thr Glu Ala Ile Ser Phe Ser Arg Thr Ser Met Ser Gly Pro Glu 7580 7585 7590 Gln Ser Thr Met Ser Gln Asp Ile Ser Ile Gly Thr Ile Pro Arg 7595 7600 7605 Ile Ser Ala Ser Ser Val Leu Thr Glu Ser Ala Lys Met Thr Ile 7610 7615 7620 Thr Thr Gln Thr Gly Pro Ser Glu Ser Thr Leu Glu Ser Thr Leu 7625 7630 7635 Asn Leu Asn Thr Ala Thr Thr Pro Ser Trp Val Glu Thr His Ser 7640 7645 7650 Ile Val Ile Gln Gly Phe Pro His Pro Glu Met Thr Thr Ser Met 7655 7660 7665 Gly Arg Gly Pro Gly Gly Val Ser Trp Pro Ser Pro Pro Phe Val 7670 7675 7680 Lys Glu Thr Ser Pro Pro Ser Ser Pro Leu Ser Leu Pro Ala Val 7685 7690 7695 Thr Ser Pro His Pro Val Ser Thr Thr Phe Leu Ala His Ile Pro 7700 7705 7710 Pro Ser Pro Leu Pro Val Thr Ser Leu Leu Thr Ser Gly Pro Ala 7715 7720 7725 Thr Thr Thr Asp Ile Leu Gly Thr Ser Thr Glu Pro Gly Thr Ser 7730 7735 7740 Ser Ser Ser Ser Leu Ser Thr Thr Ser His Glu Arg Leu Thr Thr 7745 7750 7755 Tyr Lys Asp Thr Ala His Thr Glu Ala Val His Pro Ser Thr Asn 7760 7765 7770 Thr Gly Gly Thr Asn Val Ala Thr Thr Ser Ser Gly Tyr Lys Ser 7775 7780 7785 Gln Ser Ser Val Leu Ala Asp Ser Ser Pro Met Cys Thr Thr Ser 7790 7795 7800 Thr Met Gly Asp Thr Ser Val Leu Thr Ser Thr Pro Ala Phe Leu 7805 7810 7815 Glu Thr Arg Arg Ile Gln Thr Glu Leu Ala Ser Ser Leu Thr Pro 7820 7825 7830 Gly Leu Arg Glu Ser Ser Gly Ser Glu Gly Thr Ser Ser Gly Thr 7835 7840 7845 Lys Met Ser Thr Val Leu Ser Lys Val Pro Thr Gly Ala Thr Thr 7850 7855 7860 Glu Ile Ser Lys Glu Asp Val Thr Ser Ile Pro Gly Pro Ala Gln 7865 7870 7875 Ser Thr Ile Ser Pro Asp Thr Ser Thr Arg Thr Val Ser Trp Phe 7880 7885 7890 Ser Thr Ser Pro Val Met Thr Glu Ser Ala Glu Ile Thr Met Asn 7895 7900 7905 Thr His Thr Ser Pro Leu Gly Ala Thr Thr Gln Gly Thr Ser Thr 7910 7915 7920 Leu Asp Thr Ser Ser Thr Thr Ser Leu Thr Met Thr His Ser Thr 7925 7930 7935 Ile Ser Gln Gly Phe Ser His Ser Gln Met Ser Thr Leu Met Arg 7940 7945 7950 Arg Gly Pro Glu Asp Val Ser Trp Met Ser Pro Pro Leu Leu Glu 7955 7960 7965 Lys Thr Arg Pro Ser Phe Ser Leu Met Ser Ser Pro Ala Thr Thr 7970 7975 7980 Ser Pro Ser Pro Val Ser Ser Thr Leu Pro Glu Ser Ile Ser Ser 7985 7990 7995 Ser Pro Leu Pro Val Thr Ser Leu Leu Thr Ser Gly Leu Ala Lys 8000 8005 8010 Thr Thr Asp Met Leu His Lys Ser Ser Glu Pro Val Thr Asn Ser 8015 8020 8025 Pro Ala Asn Leu Ser Ser Thr Ser Val Glu Ile Leu Ala Thr Ser 8030 8035 8040 Glu Val Thr Thr Asp Thr Glu Lys Thr His Pro Ser Ser Asn Arg 8045 8050 8055 Thr Val Thr Asp Val Gly Thr Ser Ser Ser Gly His Glu Ser Thr 8060 8065 8070 Ser Phe Val Leu Ala Asp Ser Gln Thr Ser Lys Val Thr Ser Pro 8075 8080 8085 Met Val Ile Thr Ser Thr Met Glu Asp Thr Ser Val Ser Thr Ser 8090 8095 8100 Thr Pro Gly Phe Phe Glu Thr Ser Arg Ile Gln Thr Glu Pro Thr 8105 8110 8115 Ser Ser Leu Thr Leu Gly Leu Arg Lys Thr Ser Ser Ser Glu Gly 8120 8125 8130 Thr Ser Leu Ala Thr Glu Met Ser Thr Val Leu Ser Gly Val Pro 8135 8140 8145 Thr Gly Ala Thr Ala Glu Val Ser Arg Thr Glu Val Thr Ser Ser 8150 8155 8160 Ser Arg Thr Ser Ile Ser Gly Phe Ala Gln Leu Thr Val Ser Pro 8165 8170 8175 Glu Thr Ser Thr Glu Thr Ile Thr Arg Leu Pro Thr Ser Ser Ile 8180 8185 8190 Met Thr Glu Ser Ala Glu Met Met Ile Lys Thr Gln Thr Asp Pro 8195 8200 8205 Pro Gly Ser Thr Pro Glu Ser Thr His Thr Val Asp Ile Ser Thr 8210 8215 8220 Thr Pro Asn Trp Val Glu Thr His Ser Thr Val Thr Gln Arg Phe 8225 8230 8235 Ser His Ser Glu Met Thr Thr Leu Val Ser Arg Ser Pro Gly Asp 8240 8245 8250 Met Leu Trp Pro Ser Gln Ser Ser Val Glu Glu Thr Ser Ser Ala 8255 8260 8265 Ser Ser Leu Leu Ser Leu Pro Ala Thr Thr Ser Pro Ser Pro Val 8270 8275 8280 Ser Ser Thr Leu Val Glu Asp Phe Pro Ser Ala Ser Leu Pro Val 8285 8290 8295 Thr Ser Leu Leu Thr Pro Gly Leu Val Ile Thr Thr Asp Arg Met 8300 8305 8310 Gly Ile Ser Arg Glu Pro Gly Thr Ser Ser Thr Ser Asn Leu Ser 8315 8320 8325 Ser Thr Ser His Glu Arg Leu Thr Thr Leu Glu Asp Thr Val Asp 8330 8335 8340 Thr Glu Ala Met Gln Pro Ser Thr His Thr Ala Val Thr Asn Val 8345 8350 8355 Arg Thr Ser Ile Ser Gly His Glu Ser Gln Ser Ser Val Leu Ser 8360 8365 8370 Asp Ser Glu Thr Pro Lys Ala Thr Ser Ser Met Gly Thr Thr Tyr 8375 8380 8385 Thr Met Gly Glu Thr Ser Val Ser Ile Ser Thr Ser Asp Phe Phe 8390 8395 8400 Glu Thr Ser Arg Val Gln Ile Glu Pro Thr Ser Ser Leu Thr Ser 8405 8410 8415 Gly Leu Arg Glu Thr Ser Ser Ser Glu Arg Ile Ser Ser Ala Thr 8420 8425 8430 Glu Gly Ser Thr Val Leu Ser Glu Val Pro Ser Gly Ala Thr Thr 8435 8440 8445 Glu Val Ser Arg Thr Glu Val Ile Ser Ser Arg Gly Thr Ser Met 8450 8455 8460 Ser Gly Pro Asp Gln Phe Thr Ile Ser Pro Asp Ile Ser Thr Glu 8465 8470 8475 Ala Ile Thr Arg Leu Ser Thr Ser Pro Ile Met Thr Glu Ser Ala 8480 8485 8490 Glu Ser Ala Ile Thr Ile Glu Thr Gly Ser Pro Gly Ala Thr Ser 8495 8500 8505 Glu Gly Thr Leu Thr Leu Asp Thr Ser Thr Thr Thr Phe Trp Ser 8510 8515 8520 Gly Thr His Ser Thr Ala Ser Pro Gly Phe Ser His Ser Glu Met 8525 8530 8535 Thr Thr Leu Met Ser Arg Thr Pro Gly Asp Val Pro Trp Pro Ser 8540 8545 8550 Leu Pro Ser Val Glu Glu Ala Ser Ser Val Ser Ser Ser Leu Ser 8555 8560 8565 Ser Pro Ala Met Thr Ser Thr Ser Phe Phe Ser Ala Leu Pro Glu 8570 8575 8580 Ser Ile Ser Ser Ser Pro His Pro Val Thr Ala Leu Leu Thr Leu 8585 8590 8595 Gly Pro Val Lys Thr Thr Asp Met Leu Arg Thr Ser Ser Glu Pro 8600 8605 8610 Glu Thr Ser Ser Pro Pro Asn Leu Ser Ser Thr Ser Ala Glu Ile 8615 8620 8625 Leu Ala Thr Ser Glu Val Thr Lys Asp Arg Glu Lys Ile His Pro 8630 8635 8640 Ser Ser Asn Thr Pro Val Val Asn Val Gly Thr Val Ile Tyr Lys 8645 8650 8655 His Leu Ser Pro Ser Ser Val Leu Ala Asp Leu Val Thr Thr Lys 8660 8665 8670 Pro Thr Ser Pro Met Ala Thr Thr Ser Thr Leu Gly Asn Thr Ser 8675 8680 8685 Val Ser Thr Ser Thr Pro Ala Phe Pro Glu Thr Met Met Thr Gln 8690 8695 8700 Pro Thr Ser Ser Leu Thr Ser Gly Leu Arg Glu Ile Ser Thr Ser 8705 8710 8715 Gln Glu Thr Ser Ser Ala Thr Glu Arg Ser Ala Ser Leu Ser Gly 8720 8725 8730 Met Pro Thr Gly Ala Thr Thr Lys Val Ser Arg Thr Glu Ala Leu 8735 8740 8745 Ser Leu Gly Arg Thr Ser Thr Pro Gly Pro Ala Gln Ser Thr Ile 8750 8755 8760 Ser Pro Glu Ile Ser Thr Glu Thr Ile Thr Arg Ile Ser Thr Pro 8765 8770 8775 Leu Thr Thr Thr Gly Ser Ala Glu Met Thr Ile Thr Pro Lys Thr 8780 8785 8790 Gly His Ser Gly Ala Ser Ser Gln Gly Thr Phe Thr Leu Asp Thr 8795 8800 8805 Ser Ser Arg Ala Ser Trp Pro Gly Thr His Ser Ala Ala Thr His 8810 8815 8820 Arg Ser Pro His Ser Gly Met Thr Thr Pro Met Ser Arg Gly Pro 8825 8830 8835 Glu Asp Val Ser Trp Pro Ser Arg Pro Ser Val Glu Lys Thr Ser 8840 8845 8850 Pro Pro Ser Ser Leu Val Ser Leu Ser Ala Val Thr Ser Pro Ser 8855 8860 8865 Pro Leu Tyr Ser Thr Pro Ser Glu Ser Ser His Ser Ser Pro Leu 8870 8875 8880 Arg Val Thr Ser Leu Phe Thr Pro Val Met Met Lys Thr Thr Asp 8885 8890 8895 Met Leu Asp Thr Ser Leu Glu Pro Val Thr Thr Ser Pro Pro Ser 8900 8905 8910 Met Asn Ile Thr Ser Asp Glu Ser Leu Ala Thr Ser Lys Ala Thr 8915 8920 8925 Met Glu Thr Glu Ala Ile Gln Leu Ser Glu Asn Thr Ala Val Thr 8930 8935 8940 Gln Met Gly Thr Ile Ser Ala Arg Gln Glu Phe Tyr Ser Ser Tyr 8945 8950 8955 Pro Gly Leu Pro Glu Pro Ser Lys Val Thr Ser Pro Val Val Thr 8960 8965 8970 Ser Ser Thr Ile Lys Asp Ile Val Ser Thr Thr Ile Pro Ala Ser 8975 8980 8985 Ser Glu Ile Thr Arg Ile Glu Met Glu Ser Thr Ser Thr Leu Thr 8990 8995 9000 Pro Thr Pro Arg Glu Thr Ser Thr Ser Gln Glu Ile His Ser Ala 9005 9010 9015 Thr Lys Pro Ser Thr Val Pro Tyr Lys Ala Leu Thr Ser Ala Thr 9020 9025 9030 Ile Glu Asp Ser Met Thr Gln Val Met Ser Ser Ser Arg Gly Pro 9035 9040 9045 Ser Pro Asp Gln Ser Thr Met Ser Gln Asp Ile Ser Thr Glu Val 9050 9055 9060 Ile Thr Arg Leu Ser Thr Ser Pro Ile Lys Ala Glu Ser Thr Glu 9065 9070 9075 Met Thr Ile Thr Thr Gln Thr Gly Ser Pro Gly Ala Thr Ser Arg 9080 9085 9090 Gly Thr Leu Thr Leu Asp Thr Ser Thr Thr Phe Met Ser Gly Thr 9095 9100 9105 His Ser Thr Ala Ser Gln Gly Phe Ser His Ser Gln Met Thr Ala 9110 9115 9120 Leu Met Ser Arg Thr Pro Gly Asp Val Pro Trp Leu Ser His Pro 9125 9130 9135 Ser Val Glu Glu Ala Ser Ser Ala Ser Phe Ser Leu Ser Ser Pro 9140 9145 9150 Val Met Thr Ser Ser Ser Pro Val Ser Ser Thr Leu Pro Asp Ser 9155 9160 9165 Ile His Ser Ser Ser Leu Pro Val Thr Ser Leu Leu Thr Ser Gly 9170 9175 9180 Leu Val Lys Thr Thr Glu Leu Leu Gly Thr Ser Ser Glu Pro Glu 9185 9190 9195 Thr Ser Ser Pro Pro Asn Leu Ser Ser Thr Ser Ala Glu Ile Leu 9200 9205 9210 Ala Thr Thr Glu Val Thr Thr Asp Thr Glu Lys Leu Glu Met Thr 9215 9220 9225 Asn Val Val Thr Ser Gly Tyr Thr His Glu Ser Pro Ser Ser Val 9230 9235 9240 Leu Ala Asp Ser Val Thr Thr Lys Ala Thr Ser Ser Met Gly Ile 9245 9250 9255 Thr Tyr Pro Thr Gly Asp Thr Asn Val Leu Thr Ser Thr Pro Ala 9260 9265 9270 Phe Ser Asp Thr Ser Arg Ile Gln Thr Lys Ser Lys Leu Ser Leu 9275 9280 9285 Thr Pro Gly Leu Met Glu Thr Ser Ile Ser Glu Glu Thr Ser Ser 9290 9295 9300 Ala Thr Glu Lys Ser Thr Val Leu Ser Ser Val Pro Thr Gly Ala 9305 9310 9315 Thr Thr Glu Val Ser Arg Thr Glu Ala Ile Ser Ser Ser Arg Thr 9320 9325 9330 Ser Ile Pro Gly Pro Ala Gln Ser Thr Met Ser Ser Asp Thr Ser 9335 9340 9345 Met Glu Thr Ile Thr Arg Ile Ser Thr Pro Leu Thr Arg Lys Glu 9350 9355 9360 Ser Thr Asp Met Ala Ile Thr Pro Lys Thr Gly Pro Ser Gly Ala 9365 9370 9375 Thr Ser Gln Gly Thr Phe Thr Leu Asp Ser Ser Ser Thr Ala Ser 9380 9385 9390 Trp Pro Gly Thr His Ser Ala Thr Thr Gln Arg Phe Pro Gln Ser 9395 9400 9405 Val Val Thr Thr Pro Met Ser Arg Gly Pro Glu Asp Val Ser Trp 9410 9415 9420 Pro Ser Pro Leu Ser Val Glu Lys Asn Ser Pro Pro Ser Ser Leu 9425 9430 9435 Val Ser Ser Ser Ser Val Thr Ser Pro Ser Pro Leu Tyr Ser Thr 9440 9445 9450 Pro Ser Gly Ser Ser His Ser Ser Pro Val Pro Val Thr Ser Leu 9455 9460 9465 Phe Thr Ser Ile Met Met Lys Ala Thr Asp Met Leu Asp Ala Ser 9470 9475 9480 Leu Glu Pro Glu Thr Thr Ser Ala Pro Asn Met Asn Ile Thr Ser 9485 9490 9495 Asp Glu Ser Leu Ala Thr Ser Lys Ala Thr Thr Glu Thr Glu Ala 9500 9505 9510 Ile His Val Phe Glu Asn Thr Ala Ala Ser His Val Glu Thr Thr 9515 9520 9525 Ser Ala Thr Glu Glu Leu Tyr Ser Ser Ser Pro Gly Phe Ser Glu 9530 9535 9540 Pro Thr Lys Val Ile Ser Pro Val Val Thr Ser Ser Ser Ile Arg 9545 9550 9555 Asp Asn Met Val Ser Thr Thr Met Pro Gly Ser Ser Gly Ile Thr 9560 9565 9570 Arg Ile Glu Ile Glu Ser Met Ser Ser Leu Thr Pro Gly Leu Arg 9575 9580 9585 Glu Thr Arg Thr Ser Gln Asp Ile Thr Ser Ser Thr Glu Thr Ser 9590 9595 9600 Thr Val Leu Tyr Lys Met Ser Ser Gly Ala Thr Pro Glu Val Ser 9605 9610 9615 Arg Thr Glu Val Met Pro Ser Ser Arg Thr Ser Ile Pro Gly Pro 9620 9625 9630 Ala Gln Ser Thr Met Ser Leu Asp Ile Ser Asp Glu Val Val Thr 9635 9640 9645 Arg Leu Ser Thr Ser Pro Ile Met Thr Glu Ser Ala Glu Ile Thr 9650 9655 9660 Ile Thr Thr Gln Thr Gly Tyr Ser Leu Ala Thr Ser Gln Val Thr 9665 9670 9675 Leu Pro Leu Gly Thr Ser Met Thr Phe Leu Ser Gly Thr His Ser 9680 9685 9690 Thr Met Ser Gln Gly Leu Ser His Ser Glu Met Thr Asn Leu Met 9695 9700 9705 Ser Arg Gly Pro Glu Ser Leu Ser Trp Thr Ser Pro Arg Phe Val 9710 9715 9720 Glu Thr Thr Arg Ser Ser Ser Ser Leu Thr Ser Leu Pro Leu Thr 9725 9730 9735 Thr Ser Leu Ser Pro Val Ser Ser Thr Leu Leu Asp Ser Ser Pro 9740 9745 9750 Ser Ser Pro Leu Pro Val Thr Ser Leu Ile Leu Pro Gly Leu Val 9755 9760 9765 Lys Thr Thr Glu Val Leu Asp Thr Ser Ser Glu Pro Lys Thr Ser 9770 9775 9780 Ser Ser Pro Asn Leu Ser Ser Thr Ser Val Glu Ile Pro Ala Thr 9785 9790 9795 Ser Glu Ile Met Thr Asp Thr Glu Lys Ile His Pro Ser Ser Asn 9800 9805 9810 Thr Ala Val Ala Lys Val Arg Thr Ser Ser Ser Val His Glu Ser 9815 9820 9825 His Ser Ser Val Leu Ala Asp Ser Glu Thr Thr Ile Thr Ile Pro 9830 9835 9840 Ser Met Gly Ile Thr Ser Ala Val Asp Asp Thr Thr Val Phe Thr 9845 9850 9855 Ser Asn Pro Ala Phe Ser Glu Thr Arg Arg Ile Pro Thr Glu Pro 9860 9865 9870 Thr Phe Ser Leu Thr Pro Gly Phe Arg Glu Thr Ser Thr Ser Glu 9875 9880 9885 Glu Thr Thr Ser Ile Thr Glu Thr Ser Ala Val Leu Tyr Gly Val 9890 9895 9900 Pro Thr Ser Ala Thr Thr Glu Val Ser Met Thr Glu Ile Met Ser 9905 9910 9915 Ser Asn Arg Thr His Ile Pro Asp Ser Asp Gln Ser Thr Met Ser 9920 9925 9930 Pro Asp Ile Ile Thr Glu Val Ile Thr Arg Leu Ser Ser Ser Ser 9935 9940 9945 Met Met Ser Glu Ser Thr Gln Met Thr Ile Thr Thr Gln Lys Ser 9950 9955 9960 Ser Pro Gly Ala Thr Ala Gln Ser Thr Leu Thr Leu Ala Thr Thr 9965 9970 9975 Thr Ala Pro Leu Ala Arg Thr His Ser Thr Val Pro Pro Arg Phe 9980 9985 9990 Leu His Ser Glu Met Thr Thr Leu Met Ser Arg Ser Pro Glu Asn 9995 10000 10005 Pro Ser Trp Lys Ser Ser Pro Phe Val Glu Lys Thr Ser Ser Ser 10010 10015 10020 Ser Ser Leu Leu Ser Leu Pro Val Thr Thr Ser Pro Ser Val Ser 10025 10030 10035 Ser Thr Leu Pro Gln Ser Ile Pro Ser Ser Ser Phe Ser Val Thr 10040 10045 10050 Ser Leu Leu Thr Pro Gly Met Val Lys Thr Thr Asp Thr Ser Thr 10055 10060 10065 Glu Pro Gly Thr Ser Leu Ser Pro Asn Leu Ser Gly Thr Ser Val 10070 10075 10080 Glu Ile Leu Ala Ala Ser Glu Val Thr Thr Asp Thr Glu Lys Ile 10085 10090 10095 His Pro Ser Ser Ser Met Ala Val Thr Asn Val Gly Thr Thr Ser 10100 10105 10110 Ser Gly His Glu Leu Tyr Ser Ser Val Ser Ile His Ser Glu Pro 10115 10120 10125 Ser Lys Ala Thr Tyr Pro Val Gly Thr Pro Ser Ser Met Ala Glu 10130 10135 10140 Thr Ser Ile Ser Thr Ser Met Pro Ala Asn Phe Glu Thr Thr Gly 10145 10150 10155 Phe Glu Ala Glu Pro Phe Ser His Leu Thr Ser Gly Phe Arg Lys 10160 10165 10170 Thr Asn Met Ser Leu Asp Thr Ser Ser Val Thr Pro Thr Asn Thr 10175 10180 10185 Pro Ser Ser Pro Gly Ser Thr His Leu Leu Gln Ser Ser Lys Thr 10190 10195 10200 Asp Phe Thr Ser Ser Ala Lys Thr Ser Ser Pro Asp Trp Pro Pro 10205 10210 10215 Ala Ser Gln Tyr Thr Glu Ile Pro Val Asp Ile Ile Thr Pro Phe 10220 10225 10230 Asn Ala Ser Pro Ser Ile Thr Glu Ser Thr Gly Ile Thr Ser Phe 10235 10240 10245 Pro Glu Ser Arg Phe Thr Met Ser Val Thr Glu Ser Thr His His 10250 10255 10260 Leu Ser Thr Asp Leu Leu Pro Ser Ala Glu Thr Ile Ser Thr Gly 10265 10270 10275 Thr Val Met Pro Ser Leu Ser Glu Ala Met Thr Ser Phe Ala Thr 10280 10285 10290 Thr Gly Val Pro Arg Ala Ile Ser Gly Ser Gly Ser Pro Phe Ser 10295 10300 10305 Arg Thr Glu Ser Gly Pro Gly Asp Ala Thr Leu Ser Thr Ile Ala 10310 10315 10320 Glu Ser Leu Pro Ser Ser Thr Pro Val Pro Phe Ser Ser Ser Thr 10325 10330 10335 Phe Thr Thr Thr Asp Ser Ser Thr Ile Pro Ala Leu His Glu Ile 10340 10345 10350 Thr Ser Ser Ser Ala Thr Pro Tyr Arg Val Asp Thr Ser Leu Gly 10355 10360 10365 Thr Glu Ser Ser Thr Thr Glu Gly Arg Leu Val Met Val Ser Thr 10370 10375 10380 Leu Asp Thr Ser Ser Gln Pro Gly Arg Thr Ser Ser Thr Pro Ile 10385 10390 10395 Leu Asp Thr Arg Met Thr Glu Ser Val Glu Leu Gly Thr Val Thr 10400 10405 10410 Ser Ala Tyr Gln Val Pro Ser Leu Ser Thr Arg Leu Thr Arg Thr 10415 10420 10425 Asp Gly Ile Met Glu His Ile Thr Lys Ile Pro Asn Glu Ala Ala 10430 10435 10440 His Arg Gly Thr Ile Arg Pro Val Lys Gly Pro Gln Thr Ser Thr 10445 10450 10455 Ser Pro Ala Ser Pro Lys Gly Leu His Thr Gly Gly Thr Lys Arg 10460 10465 10470 Met Glu Thr Thr Thr Thr Ala Leu Lys Thr Thr Thr Thr Ala Leu 10475 10480 10485 Lys Thr Thr Ser Arg Ala Thr Leu Thr Thr Ser Val Tyr Thr Pro 10490 10495 10500 Thr Leu Gly Thr Leu Thr Pro Leu Asn Ala Ser Arg Gln Met Ala 10505 10510 10515 Ser Thr Ile Leu Thr Glu Met Met Ile Thr Thr Pro Tyr Val Phe 10520 10525 10530 Pro Asp Val Pro Glu Thr Thr Ser Ser Leu Ala Thr Ser Leu Gly 10535 10540 10545 Ala Glu Thr Ser Thr Ala Leu Pro Arg Thr Thr Pro Ser Val Leu 10550 10555 10560 Asn Arg Glu Ser Glu Thr Thr Ala Ser Leu Val Ser Arg Ser Gly 10565 10570 10575 Ala Glu Arg Ser Pro Val Ile Gln Thr Leu Asp Val Ser Ser Ser 10580 10585 10590 Glu Pro Asp Thr Thr Ala Ser Trp Val Ile His Pro Ala Glu Thr 10595 10600 10605 Ile Pro Thr Val Ser Lys Thr Thr Pro Asn Phe Phe His Ser Glu 10610 10615 10620 Leu Asp Thr Val Ser Ser Thr Ala Thr Ser His Gly Ala Asp Val 10625 10630 10635 Ser Ser Ala Ile Pro Thr Asn Ile Ser Pro Ser Glu Leu Asp Ala 10640 10645 10650 Leu Thr Pro Leu Val Thr Ile Ser Gly Thr Asp Thr Ser Thr Thr 10655 10660 10665 Phe Pro Thr Leu Thr Lys Ser Pro His Glu Thr Glu Thr Arg Thr 10670 10675 10680 Thr Trp Leu Thr His Pro Ala Glu Thr Ser Ser Thr Ile Pro Arg 10685 10690 10695 Thr Ile Pro Asn Phe Ser His His Glu Ser Asp Ala Thr Pro Ser 10700 10705 10710 Ile Ala Thr Ser Pro Gly Ala Glu Thr Ser Ser Ala Ile Pro Ile 10715 10720 10725 Met Thr Val Ser Pro Gly Ala Glu Asp Leu Val Thr Ser Gln Val 10730 10735 10740 Thr Ser Ser Gly Thr Asp Arg Asn Met Thr Ile Pro Thr Leu Thr 10745 10750 10755 Leu Ser Pro Gly Glu Pro Lys Thr Ile Ala Ser Leu Val Thr His 10760 10765 10770 Pro Glu Ala Gln Thr Ser Ser Ala Ile Pro Thr Ser Thr Ile Ser 10775 10780 10785 Pro Ala Val Ser Arg Leu Val Thr Ser Met Val Thr Ser Leu Ala 10790 10795 10800 Ala Lys Thr Ser Thr Thr Asn Arg Ala Leu Thr Asn Ser Pro Gly 10805 10810 10815 Glu Pro Ala Thr Thr Val Ser Leu Val Thr His Pro Ala Gln Thr 10820 10825 10830 Ser Pro Thr Val Pro Trp Thr Thr Ser Ile Phe Phe His Ser Lys 10835 10840 10845 Ser Asp Thr Thr Pro Ser Met Thr Thr Ser His Gly Ala Glu Ser 10850 10855 10860 Ser Ser Ala Val Pro Thr Pro Thr Val Ser Thr Glu Val Pro Gly 10865 10870 10875 Val Val Thr Pro Leu Val Thr Ser Ser Arg Ala Val Ile Ser Thr 10880 10885 10890 Thr Ile Pro Ile Leu Thr Leu Ser Pro Gly Glu Pro Glu Thr Thr 10895 10900 10905 Pro Ser Met Ala Thr Ser His Gly Glu Glu Ala Ser Ser Ala Ile 10910 10915 10920 Pro Thr Pro Thr Val Ser Pro Gly Val Pro Gly Val Val Thr Ser 10925 10930 10935 Leu Val Thr Ser Ser Arg Ala Val Thr Ser Thr Thr Ile Pro Ile 10940 10945 10950 Leu Thr Phe Ser Leu Gly Glu Pro Glu Thr Thr Pro Ser Met Ala 10955 10960 10965 Thr Ser His Gly Thr Glu Ala Gly Ser Ala Val Pro Thr Val Leu 10970 10975 10980 Pro Glu Val Pro Gly Met Val Thr Ser Leu Val Ala Ser Ser Arg 10985 10990 10995 Ala Val Thr Ser Thr Thr Leu Pro Thr Leu Thr Leu Ser Pro Gly 11000 11005 11010 Glu Pro Glu Thr Thr Pro Ser Met Ala Thr Ser His Gly Ala Glu 11015 11020 11025 Ala Ser Ser Thr Val Pro Thr Val Ser Pro Glu Val Pro Gly Val 11030 11035 11040 Val Thr Ser Leu Val Thr Ser Ser Ser Gly Val Asn Ser Thr Ser 11045 11050 11055 Ile Pro Thr Leu Ile Leu Ser Pro Gly Glu Leu Glu Thr Thr Pro 11060 11065 11070 Ser Met Ala Thr Ser His Gly Ala Glu Ala Ser Ser Ala Val Pro 11075 11080 11085 Thr Pro Thr Val Ser Pro Gly Val Ser Gly Val Val Thr Pro Leu 11090 11095 11100 Val Thr Ser Ser Arg Ala Val Thr Ser Thr Thr Ile Pro Ile Leu 11105 11110 11115 Thr Leu Ser Ser Ser Glu Pro Glu Thr Thr Pro Ser Met Ala Thr 11120 11125 11130 Ser His Gly Val Glu Ala Ser Ser Ala Val Leu Thr Val Ser Pro 11135 11140 11145 Glu Val Pro Gly Met Val Thr Ser Leu Val Thr Ser Ser Arg Ala 11150 11155 11160 Val Thr Ser Thr Thr Ile Pro Thr Leu Thr Ile Ser Ser Asp Glu 11165 11170 11175 Pro Glu Thr Thr Thr Ser Leu Val Thr His Ser Glu Ala Lys Met 11180 11185 11190 Ile Ser Ala Ile Pro Thr Leu Ala Val Ser Pro Thr Val Gln Gly 11195 11200 11205 Leu Val Thr Ser Leu Val Thr Ser Ser Gly Ser Glu Thr Ser Ala 11210 11215 11220 Phe Ser Asn Leu Thr Val Ala Ser Ser Gln Pro Glu Thr Ile Asp 11225 11230 11235 Ser Trp Val Ala His Pro Gly Thr Glu Ala Ser Ser Val Val Pro 11240 11245 11250 Thr Leu Thr Val Ser Thr Gly Glu Pro Phe Thr Asn Ile Ser Leu 11255 11260 11265 Val Thr His Pro Ala Glu Ser Ser Ser Thr Leu Pro Arg Thr Thr 11270 11275 11280 Ser Arg Phe Ser His Ser Glu Leu Asp Thr Met Pro Ser Thr Val 11285 11290 11295 Thr Ser Pro Glu Ala Glu Ser Ser Ser Ala Ile Ser Thr Thr Ile 11300 11305 11310 Ser Pro Gly Ile Pro Gly Val Leu Thr Ser Leu Val Thr Ser Ser 11315 11320 11325 Gly Arg Asp Ile Ser Ala Thr Phe Pro Thr Val Pro Glu Ser Pro 11330 11335 11340 His Glu Ser Glu Ala Thr Ala Ser Trp Val Thr His Pro Ala Val 11345 11350 11355 Thr Ser Thr Thr Val Pro Arg Thr Thr Pro Asn Tyr Ser His Ser 11360 11365 11370 Glu Pro Asp Thr Thr Pro Ser Ile Ala Thr Ser Pro Gly Ala Glu 11375 11380 11385 Ala Thr Ser Asp Phe Pro Thr Ile Thr Val Ser Pro Asp Val Pro 11390 11395 11400 Asp Met Val Thr Ser Gln Val Thr Ser Ser Gly Thr Asp Thr Ser 11405 11410 11415 Ile Thr Ile Pro Thr Leu Thr Leu Ser Ser Gly Glu Pro Glu Thr 11420 11425 11430 Thr Thr Ser Phe Ile Thr Tyr Ser Glu Thr His Thr Ser Ser Ala 11435 11440 11445 Ile Pro Thr Leu Pro Val Ser Pro Gly Ala Ser Lys Met Leu Thr 11450 11455 11460 Ser Leu Val Ile Ser Ser Gly Thr Asp Ser Thr Thr Thr Phe Pro 11465 11470 11475 Thr Leu Thr Glu Thr Pro Tyr Glu Pro Glu Thr Thr Ala Ile Gln 11480 11485 11490 Leu Ile His Pro Ala Glu Thr Asn Thr Met Val Pro Arg Thr Thr 11495 11500 11505 Pro Lys Phe Ser His Ser Lys Ser Asp Thr Thr Leu Pro Val Ala 11510 11515 11520 Ile Thr Ser Pro Gly Pro Glu Ala Ser Ser Ala Val Ser Thr Thr 11525 11530 11535 Thr Ile Ser Pro Asp Met Ser Asp Leu Val Thr Ser Leu Val Pro 11540 11545 11550 Ser Ser Gly Thr Asp Thr Ser Thr Thr Phe Pro Thr Leu Ser Glu 11555 11560 11565 Thr Pro Tyr Glu Pro Glu Thr Thr Ala Thr Trp Leu Thr His Pro 11570 11575 11580 Ala Glu Thr Ser Thr Thr Val Ser Gly Thr Ile Pro Asn Phe Ser 11585 11590 11595 His Arg Gly Ser Asp Thr Ala Pro Ser Met Val Thr Ser Pro Gly 11600 11605 11610 Val Asp Thr Arg Ser Gly Val Pro Thr Thr Thr Ile Pro Pro Ser 11615 11620 11625 Ile Pro Gly Val Val Thr Ser Gln Val Thr Ser Ser Ala Thr Asp 11630 11635 11640 Thr Ser Thr Ala Ile Pro Thr Leu Thr Pro Ser Pro Gly Glu Pro 11645 11650 11655 Glu Thr Thr Ala Ser Ser Ala Thr His Pro Gly Thr Gln Thr Gly 11660 11665 11670 Phe Thr Val Pro Ile Arg Thr Val Pro Ser Ser Glu Pro Asp Thr 11675 11680 11685 Met Ala Ser Trp Val Thr His Pro Pro Gln Thr Ser Thr Pro Val 11690 11695 11700 Ser Arg Thr Thr Ser Ser Phe Ser His Ser Ser Pro Asp Ala Thr 11705 11710 11715 Pro Val Met Ala Thr Ser Pro Arg Thr Glu Ala Ser Ser Ala Val 11720 11725 11730 Leu Thr Thr Ile Ser Pro Gly Ala Pro Glu Met Val Thr Ser Gln 11735 11740 11745 Ile Thr Ser Ser Gly Ala Ala Thr Ser Thr Thr Val Pro Thr Leu 11750 11755 11760 Thr His Ser Pro Gly Met Pro Glu Thr Thr Ala Leu Leu Ser Thr 11765 11770 11775 His Pro Arg Thr Glu Thr Ser Lys Thr Phe Pro Ala Ser Thr Val 11780 11785 11790 Phe Pro Gln Val Ser Glu Thr Thr Ala Ser Leu Thr Ile Arg Pro 11795 11800 11805 Gly Ala Glu Thr Ser Thr Ala Leu Pro Thr Gln Thr Thr Ser Ser 11810 11815 11820 Leu Phe Thr Leu Leu Val Thr Gly Thr Ser Arg Val Asp Leu Ser 11825 11830 11835 Pro Thr Ala Ser Pro Gly Val Ser Ala Lys Thr Ala Pro Leu Ser 11840 11845 11850 Thr His Pro Gly Thr Glu Thr Ser Thr Met Ile Pro Thr Ser Thr 11855 11860 11865 Leu Ser Leu Gly Leu Leu Glu Thr Thr Gly Leu Leu Ala Thr Ser 11870 11875 11880 Ser Ser Ala Glu Thr Ser Thr Ser Thr Leu Thr Leu Thr Val Ser 11885 11890 11895 Pro Ala Val Ser Gly Leu Ser Ser Ala Ser Ile Thr Thr Asp Lys 11900 11905 11910 Pro Gln Thr Val Thr Ser Trp Asn Thr Glu Thr Ser Pro Ser Val 11915 11920 11925 Thr Ser Val Gly Pro Pro Glu Phe Ser Arg Thr Val Thr Gly Thr 11930 11935 11940 Thr Met Thr Leu Ile Pro Ser Glu Met Pro Thr Pro Pro Lys Thr 11945 11950 11955 Ser His Gly Glu Gly Val Ser Pro Thr Thr Ile Leu Arg Thr Thr 11960 11965 11970 Met Val Glu Ala Thr Asn Leu Ala Thr Thr Gly Ser Ser Pro Thr 11975 11980 11985 Val Ala Lys Thr Thr Thr Thr Phe Asn Thr Leu Ala Gly Ser Leu 11990 11995 12000 Phe Thr Pro Leu Thr Thr Pro Gly Met Ser Thr Leu Ala Ser Glu 12005 12010 12015 Ser Val Thr Ser Arg Thr Ser Tyr Asn His Arg Ser Trp Ile Ser 12020 12025 12030 Thr Thr Ser Ser Tyr Asn Arg Arg Tyr Trp Thr Pro Ala Thr Ser 12035 12040 12045 Thr Pro Val Thr Ser Thr Phe Ser Pro Gly Ile Ser Thr Ser Ser 12050 12055 12060 Ile Pro Ser Ser Thr Ala Ala Thr Val Pro Phe Met Val Pro Phe 12065 12070 12075 Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met 12080 12085 12090 Arg His Pro Gly Ser Arg Lys Phe Asn Ala Thr Glu Arg Glu Leu 12095 12100 12105 Gln Gly Leu Leu Lys Pro Leu Phe Arg Asn Ser Ser Leu Glu Tyr 12110 12115 12120 Leu Tyr Ser Gly Cys Arg Leu Ala Ser Leu Arg Pro Glu Lys Asp 12125 12130 12135 Ser Ser Ala Met Ala Val Asp Ala Ile Cys Thr His Arg Pro Asp 12140 12145 12150 Pro Glu Asp Leu Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu Leu 12155 12160 12165 Ser Asn Leu Thr Asn Gly Ile Gln Glu Leu Gly Pro Tyr Thr Leu 12170 12175 12180 Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser 12185 12190 12195 Met Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Val Gly 12200 12205 12210 Thr Ser Gly Thr Pro Ser Ser Ser Pro Ser Pro Thr Ala Ala Gly 12215 12220 12225 Pro Leu Leu Met Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu 12230 12235 12240 Gln Tyr Glu Glu Asp Met Arg Arg Thr Gly Ser Arg Lys Phe Asn 12245 12250 12255 Thr Met Glu Ser Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys 12260 12265 12270 Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu 12275 12280 12285 Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile 12290 12295 12300 Cys Thr His Arg Leu Asp Pro Lys Ser Pro Gly Leu Asn Arg Glu 12305 12310 12315 Gln Leu Tyr Trp Glu Leu Ser Lys Leu Thr Asn Asp Ile Glu Glu 12320 12325 12330 Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly 12335 12340 12345 Phe Thr His Gln Ser Ser Val Ser Thr Thr Ser Thr Pro Gly Thr 12350 12355 12360 Ser Thr Val Asp Leu Arg Thr Ser Gly Thr Pro Ser Ser Leu Ser 12365 12370 12375 Ser Pro Thr Ile Met Ala Ala Gly Pro Leu Leu Val Pro Phe Thr 12380 12385 12390 Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Gly Glu Asp Met Gly 12395 12400 12405 His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln 12410 12415 12420 Gly Leu Leu Gly Pro Ile Phe Lys Asn Thr Ser Val Gly Pro Leu 12425 12430 12435 Tyr Ser Gly Cys Arg Leu Thr Ser Leu Arg Ser Glu Lys Asp Gly 12440 12445 12450 Ala Ala Thr Gly Val Asp Ala Ile Cys Ile His His Leu Asp Pro 12455 12460 12465 Lys Ser Pro Gly Leu Asn Arg Glu Arg Leu Tyr Trp Glu Leu Ser 12470 12475 12480 Gln Leu Thr Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp 12485 12490 12495 Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Thr Ser Val 12500 12505 12510 Pro Thr Ser Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr 12515 12520 12525 Ser Gly Thr Pro Phe Ser Leu Pro Ser Pro Ala Thr Ala Gly Pro 12530 12535 12540 Leu Leu Val Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Lys 12545 12550 12555 Tyr Glu Glu Asp Met His Arg Pro Gly Ser Arg Lys Phe Asn Thr 12560 12565 12570 Thr Glu Arg Val Leu Gln Thr Leu Leu Gly Pro Met Phe Lys Asn 12575 12580 12585 Thr Ser Val Gly Leu Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu 12590 12595 12600 Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys 12605 12610 12615 Thr His Arg Leu Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln 12620 12625 12630 Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn Gly Ile Lys Glu Leu 12635 12640 12645 Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe 12650 12655 12660 Thr His Trp Ile Pro Val Pro Thr Ser Ser Thr Pro Gly Thr Ser 12665 12670 12675 Thr Val Asp Leu Gly Ser Gly Thr Pro Ser Ser Leu Pro Ser Pro 12680 12685 12690 Thr Ala Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr 12695 12700 12705 Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His His Pro Gly Ser 12710 12715 12720 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Gly 12725 12730 12735 Pro Met Phe Lys Asn Thr Ser Val Gly Leu Leu Tyr Ser Gly Cys 12740 12745 12750 Arg Leu Thr Leu Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly 12755 12760 12765 Val Asp Ala Ile Cys Thr His Arg Leu Asp Pro Lys Ser Pro Gly 12770 12775 12780 Val Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn 12785 12790 12795 Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu 12800 12805 12810 Tyr Val Asn Gly Phe Thr His Gln Thr Ser Ala Pro Asn Thr Ser 12815 12820 12825 Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr Pro 12830 12835 12840 Ser Ser Leu Pro Ser Pro Thr Ser Ala Gly Pro Leu Leu Val Pro 12845 12850 12855 Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp 12860 12865 12870 Met Arg His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 12875 12880 12885 Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly 12890 12895 12900 Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Ser Glu Lys 12905 12910 12915 Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg Leu 12920 12925 12930 Asp Pro Lys Ser Pro Gly Val Asp Arg Glu Gln Leu Tyr Trp Glu 12935 12940 12945 Leu Ser Gln Leu Thr Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr 12950 12955 12960 Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Gln Thr 12965 12970 12975 Ser Ala Pro Asn Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu 12980 12985 12990 Gly Thr Ser Gly Thr Pro Ser Ser Leu Pro Ser Pro Thr Ser Ala 12995 13000 13005 Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 13010 13015 13020 Leu Gln Tyr Glu Glu Asp Met His His Pro Gly Ser Arg Lys Phe 13025 13030 13035 Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Gly Pro Met Phe 13040 13045 13050 Lys Asn Thr Ser Val Gly Leu Leu Tyr Ser Gly Cys Arg Leu Thr 13055 13060 13065 Leu Leu Arg Pro Glu Lys Asn Gly Ala Ala Thr Gly Met Asp Ala 13070 13075 13080 Ile Cys Ser His Arg Leu Asp Pro Lys Ser Pro Gly Leu Asn Arg 13085 13090 13095 Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Ile Lys 13100 13105 13110 Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn 13115 13120 13125 Gly Phe Thr His Arg Ser Ser Val Ala Pro Thr Ser Thr Pro Gly 13130 13135 13140 Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr Pro Ser Ser Leu 13145 13150 13155 Pro Ser Pro Thr Thr Ala Val Pro Leu Leu Val Pro Phe Thr Leu 13160 13165 13170 Asn Phe Thr Ile Thr Asn Leu Gln Tyr Gly Glu Asp Met Arg His 13175 13180 13185 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 13190 13195 13200 Leu Leu Gly Pro Leu Phe Lys Asn Ser Ser Val Gly Pro Leu Tyr 13205 13210 13215 Ser Gly Cys Arg Leu Ile Ser Leu Arg Ser Glu Lys Asp Gly Ala 13220 13225 13230 Ala Thr Gly Val Asp Ala Ile Cys Thr His His Leu Asn Pro Gln 13235 13240 13245 Ser Pro Gly Leu Asp Arg Glu Gln Leu Tyr Trp Gln Leu Ser Gln 13250 13255 13260 Met Thr Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg 13265 13270 13275 Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Gly Leu 13280 13285 13290 Thr Thr Ser Thr Pro Trp Thr Ser Thr Val Asp Leu Gly Thr Ser 13295 13300 13305 Gly Thr Pro Ser Pro Val Pro Ser Pro Thr Thr Ala Gly Pro Leu 13310 13315 13320 Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr 13325 13330 13335 Glu Glu Asp Met His Arg Pro Gly Ser Arg Lys Phe Asn Ala Thr 13340 13345 13350 Glu Arg Val Leu Gln Gly Leu Leu Ser Pro Ile Phe Lys Asn Ser 13355 13360 13365 Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Ser Leu Arg 13370 13375 13380 Pro Glu Lys Asp Gly Ala Ala Thr Gly Met Asp Ala Val Cys Leu 13385 13390 13395 Tyr His Pro Asn Pro Lys Arg Pro Gly Leu Asp Arg Glu Gln Leu 13400 13405 13410 Tyr Trp Glu Leu Ser Gln Leu Thr His Asn Ile Thr Glu Leu Gly 13415 13420 13425 Pro Tyr Ser Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr 13430 13435 13440 His Gln Asn Ser Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr 13445 13450 13455 Val Tyr Trp Ala Thr Thr Gly Thr Pro Ser Ser Phe Pro Gly His 13460 13465 13470 Thr Glu Pro Gly Pro Leu Leu Ile Pro Phe Thr Phe Asn Phe Thr 13475 13480 13485 Ile Thr Asn Leu His Tyr Glu Glu Asn Met Gln His Pro Gly Ser 13490 13495 13500 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Lys 13505 13510 13515 Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys 13520 13525 13530 Arg Leu Thr Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly 13535 13540 13545 Met Asp Ala Val Cys Leu Tyr His Pro Asn Pro Lys Arg Pro Gly 13550 13555 13560 Leu Asp Arg Glu Gln Leu Tyr Cys Glu Leu Ser Gln Leu Thr His 13565 13570 13575 Asn Ile Thr Glu Leu Gly Pro Tyr Ser Leu Asp Arg Asp Ser Leu 13580 13585 13590 Tyr Val Asn Gly Phe Thr His Gln Asn Ser Val Pro Thr Thr Ser 13595 13600 13605 Thr Pro Gly Thr Ser Thr Val Tyr Trp Ala Thr Thr Gly Thr Pro 13610 13615 13620 Ser Ser Phe Pro Gly His Thr Glu Pro Gly Pro Leu Leu Ile Pro 13625 13630 13635 Phe Thr Phe Asn Phe Thr Ile Thr Asn Leu His Tyr Glu Glu Asn 13640 13645 13650 Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 13655 13660 13665 Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Asn Thr Ser Val Gly 13670 13675 13680 Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys 13685 13690 13695 His Glu Ala Ala Thr Gly Val Asp Thr Ile Cys Thr His Arg Val 13700 13705 13710 Asp Pro Ile Gly Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu 13715 13720 13725 Leu Ser Gln Leu Thr Asn Ser Ile Thr Glu Leu Gly Pro Tyr Thr 13730 13735 13740 Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Asn Pro Arg Ser 13745 13750 13755 Ser Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr Val His Leu 13760 13765 13770 Ala Thr Ser Gly Thr Pro Ser Ser Leu Pro Gly His Thr Ala Pro 13775 13780 13785 Val Pro Leu Leu Ile Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 13790 13795 13800 Leu His Tyr Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe 13805 13810 13815 Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe 13820 13825 13830 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr 13835 13840 13845 Leu Leu Arg Pro Glu Lys His Glu Ala Ala Thr Gly Val Asp Thr 13850 13855 13860 Ile Cys Thr His Arg Val Asp Pro Ile Gly Pro Gly Leu Asp Arg 13865 13870 13875 Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa 13880 13885 13890 Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn 13895 13900 13905 Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly 13910 13915 13920 Thr Ser Xaa Val Xaa Leu Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa 13925 13930 13935 Pro Xaa Xaa Thr Ser Ala Gly Pro Leu Leu Val Pro Phe Thr Leu 13940 13945 13950 Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His His 13955 13960 13965 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 13970 13975 13980 Leu Leu Gly Pro Met Phe Lys Asn Thr Ser Val Gly Leu Leu Tyr 13985 13990 13995 Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asn Gly Ala 14000 14005 14010 Ala Thr Gly Met Asp Ala Ile Cys Ser His Arg Leu Asp Pro Lys 14015 14020 14025 Ser Pro Gly Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln 14030 14035 14040 Leu Thr His Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg 14045 14050 14055 Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Val Ala 14060 14065 14070 Pro Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr Ser 14075 14080 14085 Gly Thr Pro Ser Ser Leu Pro Ser Pro Thr Thr Ala Val Pro Leu 14090 14095 14100 Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr 14105 14110 14115 Gly Glu Asp Met Arg His Pro Gly Ser Arg Lys Phe Asn Thr Thr 14120 14125 14130 Glu Arg Val Leu Gln Gly Leu Leu Gly Pro Leu Phe Lys Asn Ser 14135 14140 14145 Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Ile Ser Leu Arg 14150 14155 14160 Ser Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr 14165 14170 14175 His His Leu Asn Pro Gln Ser Pro Gly Leu Asp Arg Glu Gln Leu 14180 14185 14190 Tyr Trp Gln Leu Ser Gln Met Thr Asn Gly Ile Lys Glu Leu Gly 14195 14200 14205 Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr 14210 14215 14220 His Arg Ser Ser Gly Leu Thr Thr Ser Thr Pro Trp Thr Ser Thr 14225 14230 14235 Val Asp Leu Gly Thr Ser Gly Thr Pro Ser Pro Val Pro Ser Pro 14240 14245 14250 Thr Thr Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr 14255 14260 14265 Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His Arg Pro Gly Ser 14270 14275 14280 Arg Lys Phe Asn Ala Thr Glu Arg Val Leu Gln Gly Leu Leu Ser 14285 14290 14295 Pro Ile Phe Lys Asn Ser Ser Val Gly Pro Leu Tyr Ser Gly Cys 14300 14305 14310 Arg Leu Thr Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly 14315 14320 14325 Met Asp Ala Val Cys Leu Tyr His Pro Asn Pro Lys Arg Pro Gly 14330 14335 14340 Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His 14345 14350 14355 Asn Ile Thr Glu Leu Gly Pro Tyr Ser Leu Asp Arg Asp Ser Leu 14360 14365 14370 Tyr Val Asn Gly Phe Thr His Gln Ser Ser Met Thr Thr Thr Arg 14375 14380 14385 Thr Pro Asp Thr Ser Thr Met His Leu Ala Thr Ser Arg Thr Pro 14390 14395 14400 Ala Ser Leu Ser Gly Pro Thr Thr Ala Ser Pro Leu Leu Val Leu 14405 14410 14415 Phe Thr Ile Asn Cys Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp 14420 14425 14430 Met Arg Arg Thr Gly Ser Arg Lys Phe Asn Thr Met Glu Ser Val 14435 14440 14445 Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Asn Thr Ser Val Gly 14450 14455 14460 Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Lys Lys 14465 14470 14475 Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg Leu 14480 14485 14490 Asp Pro Lys Ser Pro Gly Leu Asn Arg Glu Gln Leu Tyr Trp Glu 14495 14500 14505 Leu Ser Lys Leu Thr Asn Asp Ile Glu Glu Leu Gly Pro Tyr Thr 14510 14515 14520 Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Gln Ser 14525 14530 14535 Ser Val Ser Thr Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu 14540 14545 14550 Arg Thr Ser Gly Thr Pro Ser Ser Leu Ser Ser Pro Thr Ile Met 14555 14560 14565 Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile 14570 14575 14580 Thr Asn Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg 14585 14590 14595 Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro 14600 14605 14610 Leu Phe Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser Gly Cys Arg 14615 14620 14625 Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Arg Val 14630 14635 14640 Asp Ala Ala Cys Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu 14645 14650 14655 Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Ser 14660 14665 14670 Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Val Ser Leu Tyr 14675 14680 14685 Val Asn Gly Phe Asn Pro Arg Ser Ser Val Pro Thr Thr Ser Thr 14690 14695 14700 Pro Gly Thr Ser Thr Val His Leu Ala Thr Ser Gly Thr Pro Ser 14705 14710 14715 Ser Leu Pro Gly His Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe 14720 14725 14730 Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa Met 14735 14740 14745 Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu 14750 14755 14760 Gln Gly Leu Leu Lys Pro Leu Phe Arg Asn Ser Ser Leu Glu Tyr 14765 14770 14775 Leu Tyr Ser Gly Cys Arg Leu Ala Ser Leu Arg Pro Glu Lys Asp 14780 14785 14790 Ser Ser Ala Met Ala Val Asp Ala Ile Cys Thr His Arg Pro Asp 14795 14800 14805 Pro Glu Asp Leu Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu Leu 14810 14815 14820 Ser Asn Leu Thr Asn Gly Ile Gln Glu Leu Gly Pro Tyr Thr Leu 14825 14830 14835 Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser 14840 14845 14850 Phe Leu Thr Thr Ser Thr Pro Trp Thr Ser Thr Val Asp Leu Gly 14855 14860 14865 Thr Ser Gly Thr Pro Ser Pro Val Pro Ser Pro Thr Thr Ala Gly 14870 14875 14880 Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu 14885 14890 14895 Gln Tyr Glu Glu Asp Met His Arg Pro Gly Ser Arg Arg Phe Asn 14900 14905 14910 Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Thr Pro Leu Phe Lys 14915 14920 14925 Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu 14930 14935 14940 Leu Arg Pro Glu Lys Gln Glu Ala Ala Thr Gly Val Asp Thr Ile 14945 14950 14955 Cys Thr His Arg Val Asp Pro Ile Gly Pro Gly Leu Asp Arg Glu 14960 14965 14970 Arg Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn Ser Ile Thr Glu 14975 14980 14985 Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly 14990 14995 15000 Phe Asn Pro Trp Ser Ser Val Pro Thr Thr Ser Thr Pro Gly Thr 15005 15010 15015 Ser Thr Val His Leu Ala Thr Ser Gly Thr Pro Ser Ser Leu Pro 15020 15025 15030 Gly His Thr Ala Pro Val Pro Leu Leu Ile Pro Phe Thr Leu Asn 15035 15040 15045 Phe Thr Ile Thr Asp Leu His Tyr Glu Glu Asn Met Gln His Pro 15050 15055 15060 Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu 15065 15070 15075 Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser 15080 15085 15090 Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys His Gly Ala Ala 15095 15100 15105 Thr Gly Val Asp Ala Ile Cys Thr Leu Arg Leu Asp Pro Thr Gly 15110 15115 15120 Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu Leu Ser Gln Leu 15125 15130 15135 Thr Asn Ser Val Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp 15140 15145 15150 Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr 15155 15160 15165 Thr Ser Ile Pro Gly Thr Ser Ala Val His Leu Glu Thr Ser Gly 15170 15175 15180 Thr Pro Ala Ser Leu Pro Gly His Thr Ala Pro Gly Pro Leu Leu 15185 15190 15195 Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu 15200 15205 15210 Glu Asp Met Arg His Pro Gly Ser Arg Lys Phe Ser Thr Thr Glu 15215 15220 15225 Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Asn Thr Ser 15230 15235 15240 Val Ser Ser Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro 15245 15250 15255 Glu Lys Asp Gly Ala Ala Thr Arg Val Asp Ala Val Cys Thr His 15260 15265 15270 Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Arg Leu Tyr 15275 15280 15285 Trp Lys Leu Ser Gln Leu Thr His Gly Ile Thr Glu Leu Gly Pro 15290 15295 15300 Tyr Thr Leu Asp Arg His Ser Leu Tyr Val Asn Gly Phe Thr His 15305 15310 15315 Gln Ser Ser Met Thr Thr Thr Arg Thr Pro Asp Thr Ser Thr Met 15320 15325 15330 His Leu Ala Thr Ser Arg Thr Pro Ala Ser Leu Ser Gly Pro Thr 15335 15340 15345 Thr Ala Ser Pro Leu Leu Val Leu Phe Thr Ile Asn Phe Thr Ile 15350 15355 15360 Thr Asn Gln Arg Tyr Glu Glu Asn Met His His Pro Gly Ser Arg 15365 15370 15375 Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro 15380 15385 15390 Val Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg 15395 15400 15405 Leu Thr Leu Leu Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val 15410 15415 15420 Asp Ala Ile Cys Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu 15425 15430 15435 Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Ser 15440 15445 15450 Ile Thr Glu Leu Gly Pro Tyr Thr Gln Asp Arg Asp Ser Leu Tyr 15455 15460 15465 Val Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Ile 15470 15475 15480 Pro Gly Thr Ser Ala Val His Leu Glu Thr Ser Gly Thr Pro Ala 15485 15490 15495 Ser Leu Pro Gly His Thr Ala Pro Gly Pro Leu Leu Val Pro Phe 15500 15505 15510 Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met 15515 15520 15525 Arg His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu 15530 15535 15540 Gln Gly Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly Pro 15545 15550 15555 Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Arg 15560 15565 15570 Gly Ala Ala Thr Gly Val Asp Thr Ile Cys Thr His Arg Leu Asp 15575 15580 15585 Pro Leu Asn Pro Gly Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu 15590 15595 15600 Ser Lys Leu Thr Arg Gly Ile Ile Glu Leu Gly Pro Tyr Leu Leu 15605 15610 15615 Asp Arg Gly Ser Leu Tyr Val Asn Gly Phe Thr His Arg Thr Ser 15620 15625 15630 Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly 15635 15640 15645 Thr Ser Gly Thr Pro Phe Ser Leu Pro Ser Pro Ala Xaa Xaa Xaa 15650 15655 15660 Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu 15665 15670 15675 Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn 15680 15685 15690 Thr Thr Glu Arg Val Leu Gln Thr Leu Leu Gly Pro Met Phe Lys 15695 15700 15705 Asn Thr Ser Val Gly Leu Leu Tyr Ser Gly Cys Arg Leu Thr Leu 15710 15715 15720 Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile 15725 15730 15735 Cys Thr His Arg Leu Asp Pro Lys Ser Pro Gly Val Asp Arg Glu 15740 15745 15750 Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn Gly Ile Lys Glu 15755 15760 15765 Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly 15770 15775 15780 Phe Thr His Trp Ile Pro Val Pro Thr Ser Ser Thr Pro Gly Thr 15785 15790 15795 Ser Thr Val Asp Leu Gly Ser Gly Thr Pro Ser Leu Pro Ser Ser 15800 15805 15810 Pro Thr Thr Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe 15815 15820 15825 Thr Ile Thr Asn Leu Lys Tyr Glu Glu Asp Met His Cys Pro Gly 15830 15835 15840 Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Ser Leu Leu 15845 15850 15855 Gly Pro Met Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly 15860 15865 15870 Cys Arg Leu Thr Leu Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr 15875 15880 15885 Gly Val Asp Ala Ile Cys Thr His Arg Leu Asp Pro Lys Ser Pro 15890 15895 15900 Gly Val Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr 15905 15910 15915 Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser 15920 15925 15930 Leu Tyr Val Asn Gly Phe Thr His Gln Thr Ser Ala Pro Asn Thr 15935 15940 15945 Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr 15950 15955 15960 Pro Ser Ser Leu Pro Ser Pro Thr Xaa Xaa Xaa Pro Leu Leu Xaa 15965 15970 15975 Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu 15980 15985 15990 Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg 15995 16000 16005 Val Leu Gln Gly Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr Ser Val 16010 16015 16020 Gly Xaa Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Xaa Glu 16025 16030 16035 Lys Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa Xaa Xaa 16040 16045 16050 Xaa Asp Pro Xaa Xaa Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp 16055 16060 16065 Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr 16070 16075 16080 Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Thr His Trp 16085 16090 16095 Ile Pro Val Pro Thr Ser Ser Thr Pro Gly Thr Ser Thr Val Asp 16100 16105 16110 Leu Gly Ser Gly Thr Pro Ser Ser Leu Pro Ser Pro Thr Thr Ala 16115 16120 16125 Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 16130 16135 16140 Leu Lys Tyr Glu Glu Asp Met His Cys Pro Gly Ser Arg Lys Phe 16145 16150 16155 Asn Thr Thr Glu Arg Val Leu Gln Ser Leu Leu Gly Pro Met Phe 16160 16165 16170 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr 16175 16180 16185 Ser Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala 16190 16195 16200 Ile Cys Thr His Arg Val Asp Pro Lys Ser Pro Gly Val Asp Arg 16205 16210 16215 Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn Gly Ile Lys 16220 16225 16230 Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn 16235 16240 16245 Gly Phe Thr His Gln Thr Ser Ala Pro Asn Thr Ser Thr Pro Gly 16250 16255 16260 Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr Pro Ser Ser Leu 16265 16270 16275 Pro Ser Pro Thr Ser Ala Gly Pro Leu Leu Val Pro Phe Thr Leu 16280 16285 16290 Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His His 16295 16300 16305 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 16310 16315 16320 Leu Leu Gly Pro Met Phe Lys Asn Thr Ser Val Gly Leu Leu Tyr 16325 16330 16335 Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asn Gly Ala 16340 16345 16350 Ala Thr Gly Met Asp Ala Ile Cys Thr His Arg Leu Asp Pro Lys 16355 16360 16365 Ser Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa 16370 16375 16380 Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg 16385 16390 16395 Xaa Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa 16400 16405 16410 Xaa Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu Xaa Thr Ser 16415 16420 16425 Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa Xaa Pro Leu 16430 16435 16440 Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr 16445 16450 16455 Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr 16460 16465 16470 Glu Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Arg Asn Ser 16475 16480 16485 Ser Leu Glu Tyr Leu Tyr Ser Gly Cys Arg Leu Ala Ser Leu Arg 16490 16495 16500 Pro Glu Lys Asp Ser Ser Ala Met Ala Val Asp Ala Ile Cys Thr 16505 16510 16515 His Arg Pro Asp Pro Glu Asp Leu Gly Leu Asp Arg Glu Arg Leu 16520 16525 16530 Tyr Trp Glu Leu Ser Asn Leu Thr Asn Gly Ile Gln Glu Leu Gly 16535 16540 16545 Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr 16550 16555 16560 His Arg Ser Ser Met Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr 16565 16570 16575 Val Asp Val Gly Thr Ser Gly Thr Pro Ser Ser Ser Pro Ser Pro 16580 16585 16590 Thr Thr Ala Gly Pro Leu Leu Ile Pro Phe Thr Leu Asn Phe Thr 16595 16600 16605 Ile Thr Asn Leu Gln Tyr Gly Glu Asp Met Gly His Pro Gly Ser 16610 16615 16620 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Gly 16625 16630 16635 Pro Ile Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys 16640 16645 16650 Arg Leu Thr Ser Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly 16655 16660 16665 Val Asp Ala Ile Cys Ile His His Leu Asp Pro Lys Ser Pro Gly 16670 16675 16680 Leu Asn Arg Glu Arg Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn 16685 16690 16695 Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu 16700 16705 16710 Tyr Val Asn Gly Phe Thr His Arg Thr Ser Val Pro Thr Thr Ser 16715 16720 16725 Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr Pro 16730 16735 16740 Phe Ser Leu Pro Ser Pro Ala Thr Ala Gly Pro Leu Leu Val Leu 16745 16750 16755 Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Lys Tyr Glu Glu Asp 16760 16765 16770 Met His Arg Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 16775 16780 16785 Leu Gln Thr Leu Leu Gly Pro Met Phe Lys Asn Thr Ser Val Gly 16790 16795 16800 Leu Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Ser Glu Lys 16805 16810 16815 Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg Leu 16820 16825 16830 Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu 16835 16840 16845 Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa 16850 16855 16860 Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa 16865 16870 16875 Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu 16880 16885 16890 Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa 16895 16900 16905 Xaa Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 16910 16915 16920 Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe 16925 16930 16935 Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro Val Phe 16940 16945 16950 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr 16955 16960 16965 Leu Leu Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala 16970 16975 16980 Ile Cys Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg 16985 16990 16995 Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr 17000 17005 17010 Glu Leu Gly Pro Tyr Thr Gln Asp Arg Asp Ser Leu Tyr Val Asn 17015 17020 17025 Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Ile Pro Gly 17030 17035 17040 Thr Ser Ala Val His Leu Glu Thr Thr Gly Thr Pro Ser Ser Phe 17045 17050 17055 Pro Gly His Thr Glu Pro Gly Pro Leu Leu Ile Pro Phe Thr Phe 17060 17065 17070 Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn Met Gln His 17075 17080 17085 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 17090 17095 17100 Leu Leu Thr Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr 17105 17110 17115 Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Gln Glu Ala 17120 17125 17130 Ala Thr Gly Val Asp Thr Ile Cys Thr His Arg Val Asp Pro Ile 17135 17140 17145 Gly Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu Leu Ser Gln 17150 17155 17160 Leu Thr Asn Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg 17165 17170 17175 Asp Ser Leu Tyr Val Asp Gly Phe Asn Pro Trp Ser Ser Val Pro 17180 17185 17190 Thr Thr Ser Thr Pro Gly Thr Ser Thr Val His Leu Ala Thr Ser 17195 17200 17205 Gly Thr Pro Ser Pro Leu Pro Gly His Thr Ala Pro Val Pro Leu 17210 17215 17220 Leu Ile Pro Phe Thr Leu Asn Phe Thr Ile Thr Asp Leu His Tyr 17225 17230 17235 Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr 17240 17245 17250 Glu Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Ser Thr 17255 17260 17265 Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg 17270 17275 17280 Pro Glu Lys His Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr 17285 17290 17295 Leu Arg Leu Asp Pro Thr Gly Pro Gly Leu Asp Arg Glu Arg Leu 17300 17305 17310 Tyr Trp Glu Leu Ser Gln Leu Thr Asn Ser Ile Thr Glu Leu Gly 17315 17320 17325 Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Asn 17330 17335 17340 Pro Trp Ser Ser Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr 17345 17350 17355 Val His Leu Ala Thr Ser Gly Thr Pro Ser Ser Leu Pro Gly His 17360 17365 17370 Thr Thr Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr 17375 17380 17385 Ile Thr Asn Leu Lys Tyr Glu Glu Asp Met His Cys Pro Gly Ser 17390 17395 17400 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Ser Leu His Gly 17405 17410 17415 Pro Met Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys 17420 17425 17430 Arg Leu Thr Leu Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly 17435 17440 17445 Val Asp Ala Ile Cys Thr His Arg Leu Asp Pro Lys Ser Pro Gly 17450 17455 17460 Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa 17465 17470 17475 Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu 17480 17485 17490 Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser 17495 17500 17505 Thr Pro Gly Thr Ser Xaa Val Xaa Leu Xaa Thr Ser Gly Thr Pro 17510 17515 17520 Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro 17525 17530 17535 Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa 17540 17545 17550 Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 17555 17560 17565 Leu Gln Gly Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr Ser Val Gly 17570 17575 17580 Xaa Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Xaa Glu Lys 17585 17590 17595 Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa 17600 17605 17610 Asp Pro Xaa Xaa Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu 17615 17620 17625 Leu Ser Xaa Leu Thr Asn Ser Ile Thr Glu Leu Gly Pro Tyr Thr 17630 17635 17640 Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser 17645 17650 17655 Ser Met Pro Thr Thr Ser Ile Pro Gly Thr Ser Ala Val His Leu 17660 17665 17670 Glu Thr Ser Gly Thr Pro Ala Ser Leu Pro Gly His Thr Ala Pro 17675 17680 17685 Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 17690 17695 17700 Leu Gln Tyr Glu Glu Asp Met Arg His Pro Gly Ser Arg Lys Phe 17705 17710 17715 Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe 17720 17725 17730 Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr 17735 17740 17745 Leu Leu Arg Pro Glu Lys Arg Gly Ala Ala Thr Gly Val Asp Thr 17750 17755 17760 Ile Cys Thr His Arg Leu Asp Pro Leu Asn Pro Gly Leu Asp Arg 17765 17770 17775 Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa 17780 17785 17790 Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn 17795 17800 17805 Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly 17810 17815 17820 Thr Ser Xaa Val Xaa Leu Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa 17825 17830 17835 Pro Xaa Xaa Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Leu 17840 17845 17850 Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa 17855 17860 17865 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 17870 17875 17880 Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr Ser Val Gly Xaa Leu Tyr 17885 17890 17895 Ser Gly Cys Arg Leu Thr Leu Leu Arg Xaa Glu Lys Xaa Xaa Ala 17900 17905 17910 Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa Asp Pro Xaa 17915 17920 17925 Xaa Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa 17930 17935 17940 Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg 17945 17950 17955 Xaa Ser Leu Tyr Val Asn Gly Phe His Pro Arg Ser Ser Val Pro 17960 17965 17970 Thr Thr Ser Thr Pro Gly Thr Ser Thr Val His Leu Ala Thr Ser 17975 17980 17985 Gly Thr Pro Ser Ser Leu Pro Gly His Thr Ala Pro Val Pro Leu 17990 17995 18000 Leu Ile Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu His Tyr 18005 18010 18015 Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr 18020 18025 18030 Glu Arg Val Leu Gln Gly Leu Leu Gly Pro Met Phe Lys Asn Thr 18035 18040 18045 Ser Val Gly Leu Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg 18050 18055 18060 Pro Glu Lys Asn Gly Ala Ala Thr Gly Met Asp Ala Ile Cys Ser 18065 18070 18075 His Arg Leu Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Xaa Leu 18080 18085 18090 Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly 18095 18100 18105 Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Xaa 18110 18115 18120 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly Thr Ser Xaa 18125 18130 18135 Val Xaa Leu Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa 18140 18145 18150 Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr 18155 18160 18165 Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser 18170 18175 18180 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Xaa 18185 18190 18195 Pro Xaa Phe Lys Xaa Thr Ser Val Gly Xaa Leu Tyr Ser Gly Cys 18200 18205 18210 Arg Leu Thr Leu Leu Arg Xaa Glu Lys Xaa Xaa Ala Ala Thr Xaa 18215 18220 18225 Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa Asp Pro Xaa Xaa Pro Gly 18230 18235 18240 Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa 18245 18250 18255 Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu 18260 18265 18270 Tyr Val Asn Gly Phe Thr His Gln Asn Ser Val Pro Thr Thr Ser 18275 18280 18285 Thr Pro Gly Thr Ser Thr Val Tyr Trp Ala Thr Thr Gly Thr Pro 18290 18295 18300 Ser Ser Phe Pro Gly His Thr Glu Pro Gly Pro Leu Leu Ile Pro 18305 18310 18315 Phe Thr Phe Asn Phe Thr Ile Thr Asn Leu His Tyr Glu Glu Asn 18320 18325 18330 Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 18335 18340 18345 Leu Gln Gly Leu Leu Thr Pro Leu Phe Lys Asn Thr Ser Val Gly 18350 18355 18360 Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys 18365 18370 18375 Gln Glu Ala Ala Thr Gly Val Asp Thr Ile Cys Thr His Arg Val 18380 18385 18390 Asp Pro Ile Gly Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu 18395 18400 18405 Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa 18410 18415 18420 Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa 18425 18430 18435 Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu 18440 18445 18450 Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa 18455 18460 18465 Xaa Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 18470 18475 18480 Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe 18485 18490 18495 Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Xaa Pro Xaa Phe 18500 18505 18510 Lys Xaa Thr Ser Val Gly Xaa Leu Tyr Ser Gly Cys Arg Leu Thr 18515 18520 18525 Leu Leu Arg Xaa Glu Lys Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa 18530 18535 18540 Xaa Cys Xaa Xaa Xaa Xaa Asp Pro Xaa Xaa Pro Gly Leu Asp Arg 18545 18550 18555 Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa 18560 18565 18570 Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn 18575 18580 18585 Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Ser Pro Gly 18590 18595 18600 Thr Ser Thr Val His Leu Ala Thr Ser Gly Thr Pro Ser Ser Leu 18605 18610 18615 Pro Gly His Thr Ala Pro Val Pro Leu Leu Ile Pro Phe Thr Leu 18620 18625 18630 Asn Phe Thr Ile Thr Asn Leu His Tyr Glu Glu Asn Met Gln His 18635 18640 18645 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 18650 18655 18660 Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr 18665 18670 18675 Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys His Gly Ala 18680 18685 18690 Ala Thr Gly Val Asp Ala Ile Cys Thr Leu Arg Leu Asp Pro Thr 18695 18700 18705 Gly Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa 18710 18715 18720 Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg 18725 18730 18735 Xaa Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa 18740 18745 18750 Xaa Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu Xaa Thr Ser 18755 18760 18765 Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa Xaa Pro Leu 18770 18775 18780 Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr 18785 18790 18795 Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr 18800 18805 18810 Glu Arg Val Leu Gln Gly Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr 18815 18820 18825 Ser Val Gly Xaa Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg 18830 18835 18840 Xaa Glu Lys Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa 18845 18850 18855 Xaa Xaa Xaa Asp Pro Xaa Xaa Pro Gly Leu Asp Arg Glu Xaa Leu 18860 18865 18870 Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly 18875 18880 18885 Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Thr 18890 18895 18900 His Arg Thr Ser Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr 18905 18910 18915 Val His Leu Ala Thr Ser Gly Thr Pro Ser Ser Leu Pro Gly His 18920 18925 18930 Thr Ala Pro Val Pro Leu Leu Ile Pro Phe Thr Leu Asn Phe Thr 18935 18940 18945 Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His Arg Pro Gly Ser 18950 18955 18960 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Ser 18965 18970 18975 Pro Ile Phe Lys Asn Ser Ser Val Gly Pro Leu Tyr Ser Gly Cys 18980 18985 18990 Arg Leu Thr Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly 18995 19000 19005 Met Asp Ala Val Cys Leu Tyr His Pro Asn Pro Lys Arg Pro Gly 19010 19015 19020 Leu Asp Arg Glu Gln Leu Tyr Cys Glu Leu Ser Gln Leu Thr His 19025 19030 19035 Asn Ile Thr Glu Leu Gly Pro Tyr Ser Leu Asp Arg Asp Ser Leu 19040 19045 19050 Tyr Val Asn Gly Phe Thr His Gln Asn Ser Val Pro Thr Thr Ser 19055 19060 19065 Thr Pro Gly Thr Ser Thr Val Tyr Trp Ala Thr Thr Gly Thr Pro 19070 19075 19080 Ser Ser Phe Pro Gly His Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro 19085 19090 19095 Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa 19100 19105 19110 Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val 19115 19120 19125 Leu Gln Gly Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr Ser Val Gly 19130 19135 19140 Xaa Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Xaa Glu Lys 19145 19150 19155 Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa 19160 19165 19170 Asp Pro Xaa Xaa Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu 19175 19180 19185 Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa 19190 19195 19200 Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Thr His Trp Ser 19205 19210 19215 Ser Gly Leu Thr Thr Ser Thr Pro Trp Thr Ser Thr Val Asp Leu 19220 19225 19230 Gly Thr Ser Gly Thr Pro Ser Pro Val Pro Ser Pro Thr Thr Ala 19235 19240 19245 Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn 19250 19255 19260 Leu Gln Tyr Glu Glu Asp Met His Arg Pro Gly Ser Arg Lys Phe 19265 19270 19275 Asn Ala Thr Glu Arg Val Leu Gln Gly Leu Leu Ser Pro Ile Phe 19280 19285 19290 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr 19295 19300 19305 Leu Leu Arg Pro Glu Lys Gln Glu Ala Ala Thr Gly Val Asp Thr 19310 19315 19320 Ile Cys Thr His Arg Val Asp Pro Ile Gly Pro Gly Leu Asp Arg 19325 19330 19335 Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa 19340 19345 19350 Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn 19355 19360 19365 Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly 19370 19375 19380 Thr Ser Xaa Val Xaa Leu Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa 19385 19390 19395 Pro Xaa Xaa Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Leu 19400 19405 19410 Asn Phe Thr Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa 19415 19420 19425 Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly 19430 19435 19440 Leu Leu Xaa Pro Xaa Phe Lys Xaa Thr Ser Val Gly Xaa Leu Tyr 19445 19450 19455 Ser Gly Cys Arg Leu Thr Leu Leu Arg Xaa Glu Lys Xaa Xaa Ala 19460 19465 19470 Ala Thr Xaa Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa Asp Pro Xaa 19475 19480 19485 Xaa Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa 19490 19495 19500 Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg 19505 19510 19515 Xaa Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Phe Gly Leu 19520 19525 19530 Thr Thr Ser Thr Pro Trp Thr Ser Thr Val Asp Leu Gly Thr Ser 19535 19540 19545 Gly Thr Pro Ser Pro Val Pro Ser Pro Thr Thr Ala Gly Pro Leu 19550 19555 19560 Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr 19565 19570 19575 Glu Glu Asp Met His Arg Pro Gly Ser Arg Lys Phe Asn Thr Thr 19580 19585 19590 Glu Arg Val Leu Gln Gly Leu Leu Thr Pro Leu Phe Arg Asn Thr 19595 19600 19605 Ser Val Ser Ser Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg 19610 19615 19620 Pro Glu Lys Asp Gly Ala Ala Thr Arg Val Asp Ala Val Cys Thr 19625 19630 19635 His Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Xaa Leu 19640 19645 19650 Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly 19655 19660 19665 Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Xaa 19670 19675 19680 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Thr Pro Gly Thr Ser Xaa 19685 19690 19695 Val Xaa Leu Xaa Thr Ser Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa 19700 19705 19710 Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr 19715 19720 19725 Ile Thr Asn Leu Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser 19730 19735 19740 Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Xaa 19745 19750 19755 Pro Xaa Phe Lys Xaa Thr Ser Val Gly Xaa Leu Tyr Ser Gly Cys 19760 19765 19770 Arg Leu Thr Leu Leu Arg Xaa Glu Lys Xaa Xaa Ala Ala Thr Xaa 19775 19780 19785 Val Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa Asp Pro Xaa Xaa Pro Gly 19790 19795 19800 Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa 19805 19810 19815 Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu 19820 19825 19830 Tyr Val Asn Gly Phe Thr His Trp Ile Pro Val Pro Thr Ser Ser 19835 19840 19845 Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Ser Gly Thr Pro Ser 19850 19855 19860 Ser Leu Pro Ser Pro Thr Thr Ala Gly Pro Leu Leu Val Pro Phe 19865 19870 19875 Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Gly Glu Asp Met 19880 19885 19890 Gly His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu 19895 19900 19905 Gln Gly Leu Leu Gly Pro Ile Phe Lys Asn Thr Ser Val Gly Pro 19910 19915 19920 Leu Tyr Ser Gly Cys Arg Leu Thr Ser Leu Arg Ser Glu Lys Asp 19925 19930 19935 Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Ile His His Leu Asp 19940 19945 19950 Pro Lys Ser Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu 19955 19960 19965 Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu 19970 19975 19980 Asp Arg Xaa Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa Xaa 19985 19990 19995 Xaa Xaa Xaa Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu Xaa 20000 20005 20010 Thr Ser Gly Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Xaa Xaa Xaa 20015 20020 20025 Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu 20030 20035 20040 Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn 20045 20050 20055 Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Xaa Pro Xaa Phe Lys 20060 20065 20070 Xaa Thr Ser Val Gly Xaa Leu Tyr Ser Gly Cys Arg Leu Thr Leu 20075 20080 20085 Leu Arg Xaa Glu Lys Xaa Xaa Ala Ala Thr Xaa Val Asp Xaa Xaa 20090 20095 20100 Cys Xaa Xaa Xaa Xaa Asp Pro Xaa Xaa Pro Gly Leu Asp Arg Glu 20105 20110 20115 Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu Thr Xaa Xaa Ile Xaa Glu 20120 20125 20130 Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa Ser Leu Tyr Val Asn Gly 20135 20140 20145 Phe Thr His Gln Thr Phe Ala Pro Asn Thr Ser Thr Pro Gly Thr 20150 20155 20160 Ser Thr Val Asp Leu Gly Thr Ser Gly Thr Pro Ser Ser Leu Pro 20165 20170 20175 Ser Pro Thr Ser Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn 20180 20185 20190 Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His His Pro 20195 20200 20205 Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu 20210 20215 20220 Leu Gly Pro Met Phe Lys Asn Thr Ser Val Gly Leu Leu Tyr Ser 20225 20230 20235 Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asn Gly Ala Ala 20240 20245 20250 Thr Arg Val Asp Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser 20255 20260 20265 Pro Gly Leu Asp Arg Glu Xaa Leu Tyr Trp Glu Leu Ser Xaa Leu 20270 20275 20280 Thr Xaa Xaa Ile Xaa Glu Leu Gly Pro Tyr Xaa Leu Asp Arg Xaa 20285 20290 20295 Ser Leu Tyr Val Asn Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20300 20305 20310 Thr Ser Thr Pro Gly Thr Ser Xaa Val Xaa Leu Xaa Thr Ser Gly 20315 20320 20325 Thr Pro Xaa Xaa Xaa Pro Xaa Xaa Thr Ala Pro Val Pro Leu Leu 20330 20335 20340 Ile Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu His Tyr Glu 20345 20350 20355 Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu 20360 20365 20370 Arg Val Leu Gln Gly Leu Leu Arg Pro Leu Phe Lys Ser Thr Ser 20375 20380 20385 Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro 20390 20395 20400 Glu Lys His Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr Leu 20405 20410 20415 Arg Leu Asp Pro Thr Gly Pro Gly Leu Asp Arg Glu Arg Leu Tyr 20420 20425 20430 Trp Glu Leu Ser Gln Leu Thr Asn Ser Val Thr Glu Leu Gly Pro 20435 20440 20445 Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr Gln 20450 20455 20460 Arg Ser Ser Val Pro Thr Thr Ser Ile Pro Gly Thr Ser Ala Val 20465 20470 20475 His Leu Glu Thr Ser Gly Thr Pro Ala Ser Leu Pro Gly His Thr 20480 20485 20490 Ala Pro Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile 20495 20500 20505 Thr Asn Leu Gln Tyr Glu Val Asp Met Arg His Pro Gly Ser Arg 20510 20515 20520 Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Lys Pro 20525 20530 20535 Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg 20540 20545 20550 Leu Thr Leu Leu Arg Pro Glu Lys Arg Gly Ala Ala Thr Gly Val 20555 20560 20565 Asp Thr Ile Cys Thr His Arg Leu Asp Pro Leu Asn Pro Gly Leu 20570 20575 20580 Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Lys Leu Thr Arg Gly 20585 20590 20595 Ile Ile Glu Leu Gly Pro Tyr Leu Leu Asp Arg Gly Ser Leu Tyr 20600 20605 20610 Val Asn Gly Phe Thr His Arg Asn Phe Val Pro Ile Thr Ser Thr 20615 20620 20625 Pro Gly Thr Ser Thr Val His Leu Gly Thr Ser Glu Thr Pro Ser 20630 20635 20640 Ser Leu Pro Arg Pro Ile Val Pro Gly Pro Leu Leu Val Pro Phe 20645 20650 20655 Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Ala Met 20660 20665 20670 Arg His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu 20675 20680 20685 Gln Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Ile Gly Pro 20690 20695 20700 Leu Tyr Ser Ser Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp 20705 20710 20715 Lys Ala Ala Thr Arg Val Asp Ala Ile Cys Thr His His Pro Asp 20720 20725 20730 Pro Gln Ser Pro Gly Leu Asn Arg Glu Gln Leu Tyr Trp Glu Leu 20735 20740 20745 Ser Gln Leu Thr His Gly Ile Thr Glu Leu Gly Pro Tyr Thr Leu 20750 20755 20760 Asp Arg Asp Ser Leu Tyr Val Asp Gly Phe Thr His Trp Ser Pro 20765 20770 20775 Ile Pro Thr Thr Ser Thr Pro Gly Thr Ser Ile Val Asn Leu Gly 20780 20785 20790 Thr Ser Gly Ile Pro Pro Ser Leu Pro Glu Thr Thr Xaa Xaa Xaa 20795 20800 20805 Pro Leu Leu Xaa Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu 20810 20815 20820 Xaa Tyr Glu Glu Xaa Met Xaa Xaa Pro Gly Ser Arg Lys Phe Asn 20825 20830 20835 Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys 20840 20845 20850 Ser Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu 20855 20860 20865 Leu Arg Pro Glu Lys Asp Gly Val Ala Thr Arg Val Asp Ala Ile 20870 20875 20880 Cys Thr His Arg Pro Asp Pro Lys Ile Pro Gly Leu Asp Arg Gln 20885 20890 20895 Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu 20900 20905 20910 Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly 20915 20920 20925 Phe Thr Gln Arg Ser Ser Val Pro Thr Thr Ser Thr Pro Gly Thr 20930 20935 20940 Phe Thr Val Gln Pro Glu Thr Ser Glu Thr Pro Ser Ser Leu Pro 20945 20950 20955 Gly Pro Thr Ala Thr Gly Pro Val Leu Leu Pro Phe Thr Leu Asn 20960 20965 20970 Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met His Arg Pro 20975 20980 20985 Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu 20990 20995 21000 Leu Met Pro Leu Phe Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser 21005 21010 21015 Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala 21020 21025 21030 Thr Arg Val Asp Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser 21035 21040 21045 Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Lys Leu Ser Gln Leu 21050 21055 21060 Thr His Gly Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg His 21065 21070 21075 Ser Leu Tyr Val Asn Gly Phe Thr His Gln Ser Ser Met Thr Thr 21080 21085 21090 Thr Arg Thr Pro Asp Thr Ser Thr Met His Leu Ala Thr Ser Arg 21095 21100 21105 Thr Pro Ala Ser Leu Ser Gly Pro Thr Thr Ala Ser Pro Leu Leu 21110 21115 21120 Val Leu Phe Thr Ile Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu 21125 21130 21135 Glu Asn Met His His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu 21140 21145 21150 Arg Val Leu Gln Gly Leu Leu Arg Pro Val Phe Lys Asn Thr Ser 21155 21160 21165 Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro 21170 21175 21180 Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala Ile Cys Thr Tyr 21185 21190 21195 Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln Leu Tyr 21200 21205 21210 Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro 21215 21220 21225 Tyr Thr Gln Asp Arg Asp Ser Leu Tyr Asn Val Gly Phe Thr Gln 21230 21235 21240 Arg Ser Ser Val Pro Thr Thr Ser Val Pro Gly Thr Pro Thr Val 21245 21250 21255 Asp Leu Gly Thr Ser Gly Thr Pro Val Ser Lys Pro Gly Pro Ser 21260 21265 21270 Ala Ala Ser Pro Leu Leu Val Leu Phe Thr Leu Asn Gly Thr Ile 21275 21280 21285 Thr Asn Leu Arg Tyr Glu Glu Asn Met Gln His Pro Gly Ser Arg 21290 21295 21300 Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Ser 21305 21310 21315 Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg 21320 21325 21330 Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Thr Ala Thr Gly Val 21335 21340 21345 Asp Ala Ile Cys Thr His His Pro Asp Pro Lys Ser Pro Arg Leu 21350 21355 21360 Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Asn 21365 21370 21375 Ile Thr Glu Leu Gly His Tyr Ala Leu Asp Asn Asp Ser Leu Phe 21380 21385 21390 Val Asn Gly Phe Thr His Arg Ser Ser Val Ser Thr Thr Ser Thr 21395 21400 21405 Pro Gly Thr Pro Thr Val Tyr Leu Gly Ala Ser Lys Thr Pro Ala 21410 21415 21420 Ser Ile Phe Gly Pro Ser Ala Ala Ser His Leu Leu Ile Leu Phe 21425 21430 21435 Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn Met 21440 21445 21450 Trp Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln 21455 21460 21465 Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu 21470 21475 21480 Tyr Ser Gly Ser Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly 21485 21490 21495 Glu Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg Pro Asp Pro 21500 21505 21510 Thr Gly Pro Gly Leu Asp Arg Glu Gln Leu Tyr Leu Glu Leu Ser 21515 21520 21525 Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp 21530 21535 21540 Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Val 21545 21550 21555 Pro Thr Thr Ser Thr Gly Val Val Ser Glu Glu Pro Phe Thr Leu 21560 21565 21570 Asn Phe Thr Ile Asn Asn Leu Arg Tyr Met Ala Asp Met Gly Gln 21575 21580 21585 Pro Gly Ser Leu Lys Phe Asn Ile Thr Asp Asn Val Met Lys His 21590 21595 21600 Leu Leu Ser Pro Leu Phe Gln Arg Ser Ser Leu Gly Ala Arg Tyr 21605 21610 21615 Thr Gly Cys Arg Val Ile Ala Leu Arg Ser Val Lys Asn Gly Ala 21620 21625 21630 Glu Thr Arg Val Asp Leu Leu Cys Thr Tyr Leu Gln Pro Leu Ser 21635 21640 21645 Gly Pro Gly Leu Pro Ile Lys Gln Val Phe His Glu Leu Ser Gln 21650 21655 21660 Gln Thr His Gly Ile Thr Arg Leu Gly Pro Tyr Ser Leu Asp Lys 21665 21670 21675 Asp Ser Leu Tyr Leu Asn Gly Tyr Asn Glu Pro Gly Leu Asp Glu 21680 21685 21690 Pro Pro Thr Thr Pro Lys Pro Ala Thr Thr Phe Leu Pro Pro Leu 21695 21700 21705 Ser Glu Ala Thr Thr Ala Met Gly Tyr His Leu Lys Thr Leu Thr 21710 21715 21720 Leu Asn Phe Thr Ile Ser Asn Leu Gln Tyr Ser Pro Asp Met Gly 21725 21730 21735 Lys Gly Ser Ala Thr Phe Asn Ser Thr Glu Gly Val Leu Gln His 21740 21745 21750 Leu Leu Arg Pro Leu Phe Gln Lys Ser Ser Met Gly Pro Phe Tyr 21755 21760 21765 Leu Gly Cys Gln Leu Ile Ser Leu Arg Pro Glu Lys Asp Gly Ala 21770 21775 21780 Ala Thr Gly Val Asp Thr Thr Cys Thr Tyr His Pro Asp Pro Val 21785 21790 21795 Gly Pro Gly Leu Asp Ile Gln Gln Leu Tyr Trp Glu Leu Ser Gln 21800 21805 21810 Leu Thr His Gly Val Thr Gln Leu Gly Phe Tyr Val Leu Asp Arg 21815 21820 21825 Asp Ser Leu Phe Ile Asn Gly Tyr Ala Pro Gln Asn Leu Ser Ile 21830 21835 21840 Arg Gly Glu Tyr Gln Ile Asn Phe His Ile Val Asn Trp Asn Leu 21845 21850 21855 Ser Asn Pro Asp Pro Thr Ser Ser Glu Tyr Ile Thr Leu Leu Arg 21860 21865 21870 Asp Ile Gln Asp Lys Val Thr Thr Leu Tyr Lys Gly Ser Gln Leu 21875 21880 21885 His Asp Thr Phe Arg Phe Cys Leu Val Thr Asn Leu Thr Met Asp 21890 21895 21900 Ser Val Leu Val Thr Val Lys Ala Leu Phe Ser Ser Asn Leu Asp 21905 21910 21915 Pro Ser Leu Val Glu Gln Val Phe Leu Asp Lys Thr Leu Asn Ala 21920 21925 21930 Ser Phe His Trp Leu Gly Ser Thr Tyr Gln Leu Val Asp Ile His 21935 21940 21945 Val Thr Glu Met Glu Ser Ser Val Tyr Gln Pro Thr Ser Ser Ser 21950 21955 21960 Ser Thr Gln His Phe Tyr Leu Asn Phe Thr Ile Thr Asn Leu Pro 21965 21970 21975 Tyr Ser Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg 21980 21985 21990 Asn Lys Arg Asn Ile Glu Asp Ala Leu Asn Gln Leu Phe Arg Asn 21995 22000 22005 Ser Ser Ile Lys Ser Tyr Phe Ser Asp Cys Gln Val Ser Thr Phe 22010 22015 22020 Arg Ser Val Pro Asn Arg His His Thr Gly Val Asp Ser Leu Cys 22025 22030 22035 Asn Phe Ser Pro Leu Ala Arg Arg Val Asp Arg Val Ala Ile Tyr 22040 22045 22050 Glu Glu Phe Leu Arg Met Thr Arg Asn Gly Thr Gln Leu Gln Asn 22055 22060 22065 Phe Thr Leu Asp Arg Ser Ser Val Leu Val Asp Gly Tyr Ser Pro 22070 22075 22080 Asn Arg Asn Glu Pro Leu Thr Gly Asn Ser Asp Leu Pro Phe Trp 22085 22090 22095 Ala Val Ile Leu Ile Gly Leu Ala Gly Leu Leu Gly Leu Ile Thr 22100 22105 22110 Cys Leu Ile Cys Gly Val Leu Val Thr Thr Arg Arg Arg Lys Lys 22115 22120 22125 Glu Gly Glu Tyr Asn Val Gln Gln Gln Cys Pro Gly Tyr Tyr Gln 22130 22135 22140 Ser His Leu Asp Leu Glu Asp Leu Gln 22145 22150 6 32 DNA synthetic 6 accggatcca tgggccacac agagcctggc cc 32 7 29 DNA synthetic 7 tgtaagctta ggcagggagg atggagtcc 29

Claims (20)

We claim:
1. An isolated nucleic acid molecule encoding CA125.
2. The isolated nucleic acid molecule of claim 1 comprising the sequence of SEQ ID NO: 4.
3. The isolated nucleic acid molecule of claim 2 wherein the sequence has at least about 70% homology with SEQ ID NO: 4.
4. The isolated nucleic acid molecule of claim 2 wherein said molecule is a fragment thereof.
5. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 1.
6. The isolated nucleic acid molecule of claim 5 wherein the sequence has at least about 70% homology with SEQ ID NO: 1.
7. The isolated nucleic acid molecule of claim 5 wherein said molecule is a fragment thereof.
8. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 2.
9. The isolated nucleic acid molecule of claim 8 wherein the sequence has at least about 70% homology with SEQ ID NO: 2.
10. The isolated nucleic acid molecule of claim 8 wherein said molecule is a fragment thereof.
11. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 3.
12. The isolated nucleic acid molecule of claim 11 wherein the sequence has at least about 70% homology with SEQ ID NO: 3.
13. The isolated nucleic acid molecule of claim 11 wherein said molecule is a fragment thereof.
14. A polypeptide with the amino acid sequence selected from the group consisting of: (a) the amino acid sequence set forth in SEQ ID NO: 5; (b) an amino acid sequence having at least 50% sequence identity to said sequence; (c) a conservative variant of an one of (a) to (b); and (d) a fragment of any one of (a) to (c).
15. A purified antibody that selectively binds to an amino acid sequence of the CA125 protein:
(a) wherein the amino acid sequence of the CA125 protein comprises the amino acid sequence set forth in SEQ ID NO: 5;
(b) an amino acid sequence having at least 50% sequence identity to said sequence;
(c) a conservative variant of any one of (a) to (b); and
(d) a fragment of any one of (a) to (c).
16. The purified antibody of claim 15 wherein said sequence identity is at least 60%.
17. The purified antibody of claim 15 wherein said sequence identity is at least 70%.
18. The purified antibody of claim 15 wherein said sequence identity is at least 80%.
19. The purified antibody of claim 15 wherein said sequence identity is at least 90%.
20. A method to make a purified fragment of the CA125 polypeptide of SEQ ID NO: 5 comprising:
(a) expressing a portion of the isolated nucleic acid molecule set out in SEQ ID NO: 4 to obtain a fragment of the CA125 molecule; and
(b) purifying said fragment of the CA125 molecule.
US10/715,066 2001-04-17 2003-11-17 CA125 gene and its use for diagnostic and therapeutic interventions Abandoned US20040127401A1 (en)

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US9556245B2 (en) 2017-01-31
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