US20030130686A1 - Distal protection device and method - Google Patents

Distal protection device and method Download PDF

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Publication number
US20030130686A1
US20030130686A1 US10/346,373 US34637303A US2003130686A1 US 20030130686 A1 US20030130686 A1 US 20030130686A1 US 34637303 A US34637303 A US 34637303A US 2003130686 A1 US2003130686 A1 US 2003130686A1
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US
United States
Prior art keywords
elongate member
emboli capturing
emboli
lumen
distal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US10/346,373
Inventor
John Daniel
Thomas Broome
David Holtan
Robert Cassell
Daniel Adams
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Boston Scientific Scimed Inc
Original Assignee
Scimed Life Systems Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25204805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20030130686(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/813,794 external-priority patent/US5827324A/en
Application filed by Scimed Life Systems Inc filed Critical Scimed Life Systems Inc
Priority to US10/346,373 priority Critical patent/US20030130686A1/en
Publication of US20030130686A1 publication Critical patent/US20030130686A1/en
Abandoned legal-status Critical Current

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Definitions

  • the present invention deals with an emboli capturing system. More specifically, the present invention deals with an emboli capturing system and method for capturing embolic material in a blood vessel during an atherectomy or thrombectomy procedure.
  • Blood vessels can become occluded (blocked) or stenctic (narrowed) in one of a number of ways.
  • a stenosis may be formed by an atheroma which is typically a harder calcified substance which forms on the lumen walls of the blood vessel.
  • the stenosis can be formed of a thrombus material which is typically much softer than an atheroma, but can nonetheless cause restricted blood flow in the lumen of the blood vessel. Thrombus formation can be particularly problematic in a saphenous vein graft (SVG).
  • SVG saphenous vein graft
  • stenotic lesion stenosis
  • the first is to deform the stenosis to reduce the restriction within the lumen of the blood vessel. This type of deformation (or dilatation) is typically performed using balloon angioplasty.
  • Another method of treating stenotic vasculature is to attempt to completely remove either the entire stenosis, or enough of the stenosis to relieve the restriction in the blood vessel. Removal of the stenotic lesion has been done through the use of radio frequency (RF) signals transmitted via conductors, and through the use of lasers, both of which treatments are meant to ablate (i.e., super heat an vaporize) the stenosis. Removal of the stenosis has also been accomplished using thrombectomy or atherectomy. During thrombectomy and atherectomy, the stenosis is mechanically cut or abraded away from the vessel.
  • RF radio frequency
  • a final technique for dealing with the fragments of the stenosis which are severed during atherectomy is to place a device distal to the stenosis during atherectomy to catch the pieces of the stenosis as they are severed, and to remove those pieces along with the capturing device when the atherectomy procedure is complete.
  • capture devices have included expandable filters which are placed distal of the stenosis to capture stenosis fragments. Problems are also associated with this technique. For, example, delivery of such devices in a low profile, pre-deployment configuration can be difficult. Further, some devices include complex and cumbersome actuation mechanisms. Also, retrieving such capture devices, after they have captured emboli, can be difficult as well.
  • An emboli capturing system captures emboli in a body lumen.
  • a first elongate member has a proximal fend and a distal end.
  • An expandable emboli capturing device is mounted proximate the distal end of the first elongate member, and is movable between a radially expanded position and a radially contracted position. When in the expanded position, the emboli capturing device forms a basket with a proximally opening mouth.
  • a second elongate member has a proximal and a distal end with a lumen extending therebetween. The lumen is sized to slidably receive a portion of the first elongate member.
  • An expandable delivery device is mounted to the distal end of the second elongate member and is movable from a radially retracted position to a radially expanded position.
  • the delivery device has a receiving end configured to receive the emboli capturing device, and retains at least the mouth of the emboli capturing device in a radially retracted position.
  • FIG. 1 shows a distal protection device of the present invention in a deployed position.
  • FIG. 2 shows the, distal protection device shown in FIG. 1 in a collapsed position.
  • FIG. 3 shows an end view of a portion of the distal protection device shown in FIGS. 1 and 2.
  • FIG. 4 shows a cross sectional view of a portion of the distal protection device shown in FIGS. 1 - 3 in the deployed position.
  • FIG. 5 shows a second embodiment of the distal protection device according to the present invention in a deployed position.
  • FIG. 6 shows an end view of the distal protection device shown in FIG. 5.
  • FIG. 7 shows a cross sectional view of the distal protection device shown in FIGS. 5 and 6 in then collapsed position.
  • FIG. 8 shows a third embodiment of a distal protection device according to the present invention in a deployed position.
  • FIG. 9 is a side sectional view of an alternate embodiment illustrating how the expandable members of the present invention are attached to a guide wire.
  • FIG. 10 is a sectional view taken along section lines 10 - 10 in FIG. 9.
  • FIGS. 11A and 11B show a fourth and fifth embodiment, respectively, of a distal protection device according to the present invention in a deployed position.
  • FIG. 12 illustrates the operation of a distal protection device in accordance with the present invention.
  • FIGS. 13 A- 17 B show additional embodiments of distal protection devices which expand and collapse based on movement of a mechanical actuator.
  • FIGS. 18 A- 18 D illustrate an additional embodiment of a distal protection device which is deployed and collapsed using a rolling flap configuration.
  • FIG. 19 illustrates another embodiment in accordance with the present invention in which the protection device is deployed using fluid pressure and a movable collar.
  • FIGS. 20A and 20B illustrate another aspect of the present invention in which two longitudinally movable members used to deploy the distal protection device are disconnectably locked to one another.
  • FIGS. 21 A- 21 C illustrate another embodiment in accordance with the present invention in which, the protection device is formed with a shape memory alloy frame and an attached filter or mesh mounted to the frame.
  • FIGS. 22 A- 22 C illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21 A- 21 C are delivered and deployed.
  • FIGS. 23 A- 23 E illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21 A- 21 C are retrieved.
  • FIGS. 24 A- 24 C illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21 A- 21 C are retrieved.
  • FIG. 1 illustrates protection device 10 in a deployed position within the lumen of a blood vessel 12 .
  • Protection device 10 preferably includes hollow.
  • guidewire 14 (or a hypotube having the same general dimensions as a guidewire) having a coil tip 16 , and a capturing assembly 18 .
  • Capturing assembly 18 in the embodiment shown in FIG. 1, includes an inflatable and expandable member 20 and mesh 22 .
  • An interior of expandable member 20 is preferably coupled for fluid communication with an inner lumen of guidewire 14 at a distal region of guidewire 14 .
  • inflatable member 20 When deployed, inflatable member 20 inflates and expands to the position shown in FIG. 1 such that capturing assembly. 18 has an outer periphery which approximates the inner periphery of lumen 12 .
  • Mesh 22 is preferably formed of woven or braided fibers or wires, or a microporous membrane, or other suitable filtering or netting type material.
  • mesh 22 is a microporous membrane having holes therein with a diameter of approximately 100 ⁇ m.
  • Mesh 22 can be disposed relative to inflatable member 20 in a number of different ways
  • mesh 22 can be formed of a single generally cone shaped piece which is secured to the outer or inner A periphery of inflatable member 20 .
  • mesh 22 can be formed as a spiral strip which is secured about the outer or inner periphery of inflatable member 20 filling the gaps between the loops of inflatable member 20 .
  • mesh 22 can be formed of a number of discrete pieces which are assembled onto inflatable member 20 .
  • Hollow guidewire 14 preferably has a valve 24 coupled in a proximal portion thereof
  • a syringe is preferably connected to the proximal end of guidewire 14 , which preferably includes a fluid hypotube.
  • the syringe is used to pressurize the fluid such that fluid is introduced through the lumen of hollow guidewire 14 , through valve 24 , and into inflatable member 20 .
  • inflatable member 20 Upon being inflated, inflatable member 20 expands radially outwardly from the outer surface of guidewire 14 and carries mesh 22 into the deployed position shown in FIG. 1.
  • capturing assembly, or filter assembly, 18 is deployed distally of stenosis 26 so that stenosis 26 can be If severed and fragmented, and so the fragments from stenosis 26 are carried by blood flow (indicated by arrow 28 ) into the basket or chamber formed by the deployed filter assembly 18 .
  • Filter assembly 18 is then collapsed and removed from vessel 12 with the fragments of stenosis 26 contained therein.
  • FIG. 2 illustrates protection device 10 with filter assembly 18 in the collapse position. Similar items to those shown in FIG. 1 are similarly numbered.
  • FIG. 2 illustrates that mesh 22 is easily collapsible A with inflatable member 20 .
  • fluid is preferably removed from inflatable member 20 through the lumen of hollow guidewire 14 and through two way valve 24 . This can be done using the syringe to pull a vacuum, or using any other type of suitable fluid removal system.
  • Inflatable member 20 is preferably formed of a material having some shape memory. Thus, when inflatable member 20 is collapsed, it collapses to approximate the outer diameter of hollow guidewire 14 .
  • inflatable member 20 is formed of a resilient, shape memory material such that it is inflated by introducing fluid under pressure through the lumen in hollow guidewire 14 into inflatable member 20 . When pressure is released from the lumen in hollow guidewire 14 , inflatable member 20 is allowed to force fluid out from the interior thereof through two-way valve 24 and to resume; its initial collapsed position. Again, this results in filter assembly 18 assuming its collapsed position illustrated in FIG. 2.
  • FIG. 3 illustrates a view taken from the distal end of device 10 with mesh 22 removed for clarity.
  • FIG. 3 shows that, when inflatable member 20 is deployed outwardly, mesh 22 (when deployed between the loops of inflatable member 20 ) forms a substantially lumen filling filter which allows blood to flow therethrough, but which provides a mechanism for receiving and retaining stenosis fragments carried into mesh 22 by blood flow through the vessel.
  • FIG. 3 also shows that inflatable member 20 preferably has a proximal end portion 29 which is connected to the outer periphery of guidewire 14 .
  • end 29 need not be connected to guidewire 14 , it is preferably connected using adhesive or any others suitable connection mechanism. By fixedly connecting proximal end portion 29 to guidewire 14 , this increases the stability of the filter assembly 18 upon deployment.
  • FIG. 4 is a cross sectional view of a portion of protection device 10 .
  • FIG. 4 shows protection device 10 with filter assembly 18 in the expanded or deployed position.
  • FIG. 4 also better illustrates that guidewire 14 is hollow and has a longitudinal lumen 30 extending therethrough. Longitudinal lumen 30 is connected in fluid communication with an interior of inflatable member 20 through aperture 32 which is provided in the wall of guidewire 14 .
  • FIG. 4 also shows that, in one preferred embodiment, a core wire 34 extends through lumen 30 from a proximal end thereof where it is preferably brazed to a portion of a hypotube which may be connected to the proximal portion of guidewire 14 .
  • the core wire 34 extends to the distal end of guidewire 14 where it is connected to coil tip 16 .
  • coil tip 16 is brazed or otherwise welded or suitably connected to the distal portion of core wire 34 .
  • FIG. 4 further shows that, in the preferred embodiment, inflatable member 20 inflates to a generally helical, conical shape to form a basket opening toward the proximal end of guidewire 14 .
  • FIG. 4 further illustrates, in the preferred embodiment, mesh 22 has a distal portion 38 which is connected to the exterior surface of guidewire 14 , at a distal region thereof, through adhesive 36 or any other suitable connection mechanism.
  • FIG. 5 illustrates a second embodiment of a distal protection device 40 in accordance with the present invention.
  • Device 40 includes hollow guidewire 42 , filter assembly 44 and coil tip 16 .
  • Filter assembly 44 includes a plurality of inflatable struts 46 and mesh 47 .
  • Each strut 46 has a distal end 48 and proximal end 50 .
  • Inflatable struts 46 also have an interior which is coupled in fluid communication, through distal end 48 thereof, with the lumen in hollow guidewire 42 .
  • Struts 46 are preferably configured such that, upon being inflated, the proximal ends 50 deploy radially outwardly away from the outer surface of hollow guidewire 42 to assume a dimension which approximates the inner dimension of lumen 58 in which they are inserted.
  • Mesh 47 is deployed either on the outer or inner surface of inflatable struts 46 , such that, when the inflatable struts 46 are deployed radially outwardly, mesh 47 forms a generally conical basket opening toward the proximal end of hollow guidewire 42 .
  • mesh 47 can be applied to either the outer or the inner surface of struts 46 . It can be applied to struts 46 as one unitary conical piece which is adhered about distal ends 48 of struts 46 using adhesive (or about the distal end of guidewire 42 using adhesive) and secured to the surface of the struts 46 also using adhesive. Alternatively, mesh 47 can be applied to struts 46 in a plurality of pieces which are individually or simultaneously secured to, and extend between, struts 46 .
  • FIG. 6 is an end view of distal protection device 40 shown in FIG. 5 taken from the distal end of distal protection device 40 .
  • mesh 47 forms a substantially lumen-filling filter which allows blood to flow therethrough, but which provides a mechanism for receiving and retaining stenosis fragments from stenosis 56 carried into mesh 47 by blood flow through the vessel.
  • FIG. 7 is a cross sectional view of a portion of distal protection device 40 shown in FIGS. 5 and 6.
  • FIG. 7 shows filter assembly 44 in the collapsed position in which it approximates the outer diameter of guidewire 42 .
  • FIG. 7 also shows that, in the preferred embodiment, the distal ends 48 of struts 46 are in fluid communication with an inner lumen 52 in hollow guidewire 42 through apertures 54 in the wall of guidewire 42 .
  • FIG. 8 illustrates another embodiment of a distal protection device 60 in accordance with the present invention.
  • Distal protection device 60 is similar to those shown in other figures, and similar items are similarly numbered.
  • distal protection device 60 includes hollow guidewire 63 which has a lumen in fluid communication with an interior of a pair of inflatable struts 62 .
  • Inflatable struts 62 have an inner surface 64 which is generally concave, or hemispherical, or otherwise appropriately shaped such that it extends about a portion of the outer surface of hollow guidewire 63 .
  • Mesh portions 66 extend between the inflatable struts 62 so that inflatable struts 62 and mesh portions 66 , when deployed outwardly as shown in FIG. 8, form a basket shape which opens toward the proximal end of hollow guidewire 63 .
  • FIG. 9 illustrates another system for attaching inflatable struts to a hollow guidewire for a distal protection device 70 in accordance with the present invention.
  • Distal protection device 70 is similar to the distal protection devices shown in the previous figures in that a plurality of inflatable struts 72 are provided& and preferably have a mesh portion extending therebetween. For the sake of clarity, the mesh portion is eliminated from FIG. 9. However, it will be understood that when deployed distal protection device 70 forms a generally basket-shaped filter assembly which opens toward the proximal end of hollow guidewire 74 .
  • hollow guidewire 74 has a distal end 75 which is open.
  • An endcap 76 is disposed about the distal end 75 of hollow guidewire 74 and defines an internal chamber or passageway 78 .
  • Endcap 76 has a proximal end 80 which has openings therein for receiving the ends of inflatable struts 72 .
  • the operator pressurizes fluid within the lumen of hollow guidewire 74 forcing fluid out through distal end. 75 of hollow guidewire 74 , through passageway 78 , and into inflatable struts 72 .
  • the operator draws a vacuum which pulls the fluid back out of inflatable struts 72 , through passageway 78 and, if necessary, into the lumen of hollow guidewire 74 .
  • FIG. 10 is an end view of endcap 76 taken along lines 10 - 10 in FIG. 9.
  • FIG. 10 shows that proximal end 80 of endcap 76 preferably includes a first generally central aperture 82 for receiving the distal end of hollow guidewire 74 .
  • Aperture 82 is sized just larger than, or approximating, the outer diameter of hollow guidewire 74 such that it fits snugly over the distal end 75 of hollow guidewire 74 .
  • Endcap, 76 is then fixedly connected to the distal end 75 of hollow guidewire 74 through a friction fit, a suitable adhesive, welding, brazing, or another suitable connection technique.
  • FIG. 10 also shows that proximal end 80 of endcap 76 includes a plurality of apertures 84 which are spaced from one another about end 80 . Apertures 84 are sized to receive open ends of inflatable struts 72 . In the preferred embodiment, inflatable struts 72 are secured within apertures 84 using a suitable adhesive, or another suitable connection technique. Also, in the preferred embodiment, spring tip 16 is embedded in, or otherwise suitably connected to, endcap 76 .
  • FIG. 11A shows distal protection device 90 which includes hollow guidewire 92 having a lumen running therethrough, inflatable member 94 and mesh portion 96 .
  • FIG. 11A shows that inflatable member 94 , when inflated, forms a ring about the outer surface of hollow guidewire 92 .
  • the ring has an inner periphery 98 which is spaced from the outer surface of hollow guidewire 92 substantially about the entire radial periphery of hollow guidewire 92 .
  • Mesh portion extends between the outer surface of hollow guide 92 and the inner periphery 98 of inflatable member 94 .
  • a substantially disc-shaped filter assembly is provided upon deployment of distal protection device 90 .
  • deployment of distal protection device 90 is accomplished by providing fluid through the inner lumen of hollow guidewire 92 into an interior of inflatable member 94 , which is in fluid communication with the inner lumen of hollow guidewire 92 .
  • end 100 of inflatable member 94 is coupled to a coupling portion 102 of inflatable member 94 such that, stability is added to inflatable member 94 , when it is inflated.
  • FIG. 11B illustrates another distal protection device 104 which includes a hollow guidewire 106 and an inflatable member 108 .
  • Device 104 is similar to distal protection device 90 except that, rather than having only a single inflatable ring upon deployment of distal protection device 104 , a plurality of generally equal-diameter rings are formed into a helix shape.
  • distal protection device 104 includes a mesh sleeve 110 which extends about the outer or inner surface of the helix formed by inflatable member 108 .
  • mesh sleeve 110 is connected to the outer surface of hollow guidewire 106 in a region 112 proximate, but distal of, inflatable member 108 .
  • distal protection device 104 forms a generally basket shaped filter assembly which opens toward a proximal end of guidewire 106 .
  • both distal protection device 90 shown in FIG. 11A and distal protection device 104 shown in FIG. 11B are preferably collapsible. Therefore, when collapsed, the distal protection devices 90 and 104 preferably have an outer dimension which approximates the outer dimension of hollow guidewires 92 and 106 , respectively.
  • distal protection devices 90 and 104 can either be biased in the deployed or collapsed positions, and deployment and collapse can be obtained either by pulling a vacuum or pressurizing the fluid within the lumen of the hollow guidewires 92 and 106 .
  • FIG. 12 illustrates the use of a distal protection device in accordance with the present invention.
  • Device 10 is shown filtering stenosis fragments from the blood flowing through the lumen of vessel 12 .
  • FIG. 12 also shows a dilatation device 120 which can be any suitable dilatation device for dilating, cutting, fragmenting, or abrading, portions of stenosis 26 .
  • device 120 is used in an over-the-wire fashion over hollow guidewire 14 .
  • filter assembly 18 is first advanced (using guidewire 14 ) distal of stenosis 26 . Then, filter assembly 18 is deployed outwardly to the expanded position.
  • Dilatation device 120 is then advanced over guidewire 14 to stenosis 26 and is used to fragment or abrade stenosis 26 .
  • the fragments are received within the basket of filter assembly 18 .
  • Filter assembly 18 is then collapsed, and filter assembly 18 and dilatation device 120 are removed from vessel 12 .
  • dilatation device 120 can be removed first and filter assembly 18 is then removed along with guidewire 14 .
  • the stenosis removal device 120 used to fragment stenosis 26 can be advanced over guidewire 14 . Therefore, the device according to the present invention is dual functioning in that it captures emboli and serves as a guidewire. The present invention does not require adding an additional device to the procedure. Instead, the present invention simply replaces a conventional guidewire with a multi-functional device.
  • FIGS. 13 A- 17 B illustrate embodiments of various distal protection devices wherein deployment and contraction of the distal protection device is accomplished through a mechanical push/pull arrangement.
  • FIG. 13A shows device 122 in an undeployed position and FIG. 13B shows device 122 in a depolyed position.
  • Distal protection device 122 includes a slotted Nitinol tube 124 which has a lumen 126 extending therethrough. Tube 124 has a plurality of slots 128 at a distal region thereof. The distal portion of slots 128 are covered by mesh 130 which, in the preferred embodiment, is a flexible microporous membrane.
  • Device 122 also preferably includes a mandrel 132 which extends through the inner lumen 126 of tube 124 and is attached to the distal end of tube 124 .
  • mandrel 132 is attached to the distal end of tube 124 by an appropriate adhesive, brazing, welding, or another suitable connection technique.
  • Tube 124 also has, on its inner periphery in a proximal region thereof, a plurality of locking protrusions 134 .
  • Lock protrusions 134 are preferably arranged about a proximal expandable region 136 disposed on mandrel 132 .
  • tube 124 In order to deploy device 122 into the deployed position shown in FIG. 13B, the operator preferably first advances tube 124 distally of the lesion to be fragmented.
  • tube 124 has a size on the order of a guidewire, such as a 0.014 inch outer diameter. Therefore, it easily advances beyond the stenosis to be fragmented.
  • the operator then pushes on the proximal region of tube 124 and pulls on the proximal end of mandrel 132 . This causes two things to happen. First, this causes the struts formed by slots 128 to expand radially outwardly, and carry with them, microporous membrane 130 .
  • microporous membrane 130 forms a generally basket shaped filter assembly which opens toward the proximal end of tube 124 .
  • proximal expandable member 136 expands and engages protrusions 134 . This locks device 122 in the developed and expanded position.
  • the physician simply pushes on mandrel 132 and pulls on the proximal end of tube 124 . This causes device 122 to return to the undeployed position shown in FIG. 13A.
  • device 122 can optionally be provided with a stainless steel proximal hypotube attachment.
  • the struts defined by slots 128 can be expanded and retracted using a fluid coupling instead of a mandrel.
  • the proximal end of tube 124 can be coupled to a pressurizable fluid source.
  • FIG. 14A illustrates distal protection device 140 which is similar to that shown in FIGS. 13A and 13B, except that the struts 142 are formed of a metal or polymer material and are completely covered by mesh 144 .
  • Mesh 144 includes two mesh portions, 146 and 148 .
  • Mesh portion 146 is proximal of mesh portion 148 on device 140 and is a relatively loose mesh which will allow stenosis fragments to pass therethrough.
  • mesh 148 is a fairly tight mesh, or a microporous membrane, (or simply loose mesh portion 146 with a microporous membrane or other suitable filter material bonded or cast or otherwise disposed thereover) which does not allow the fragments to pass therethrough and therefore captures and retains the fragments therein.
  • the mesh portions can provide a memory set which, in the relaxed position, is either deployed or collapsed.
  • FIG. 14B illustrates a device 150 which is similar to device 140 shown in FIG. 14A, except struts 142 are eliminated and the two mesh portions 146 ′ and 148 ′ are simply joined together at a region 152 . Also, the two mesh portions 146 ′ and 148 ′ are not two different discrete mesh portions but are formed of the same braided mesh material wherein the braid simply has a different pitch. The wider pitch in region 146 ′ provides a looser mesh, whereas the narrower pitch in region 148 ′ provides a tighter mesh that traps the embolic material.
  • FIG. 14C illustrates a distal protection device 160 which is similar to that shown in FIG. 14A.
  • distal protection device 160 includes a plurality of struts 162 on a proximal region thereof and a plurality of struts 164 on the distal region thereof.
  • Struts 162 are spaced further apart than struts 164 about the periphery of protection device 160 . Therefore, struts 162 define openings 166 which are larger than the openings 168 defined by struts 164 and allow stenosis fragments to pass therethrough.
  • struts 164 have secured to the interior surface thereof a filter or mesh portion 170 . When deployed, filter portion 170 forms a substantially basket shaped filter device opening toward the proximal region of tube 172 .
  • FIG. 15 illustrates the operation of another distal protection device 176 .
  • Distal protection device 176 includes a tube 178 and a push/pull wire 180 .
  • Tube 178 has, at the distal end thereof, a filter assembly 182 .
  • Filter assembly 182 includes a plurality of preferably metal struts 184 which have a microporous membrane, or other suitable mesh 186 disposed thereon.
  • Tube 178 also preferably includes end cap 188 and umbrella-like expansion structure 190 disposed at a distal region thereof.
  • Expansion structure 190 is connected to the distal region of tube 178 and to metal struts 184 such that, when push/pull wire 180 is pulled relative to tube 178 , expansion member 190 exerts a radial, outwardly directed force on struts 184 causing them to expand radially outwardly relative to the outer surface of tube 178 .
  • This causes microporous membrane or mesh 186 to be deployed in a manner opening toward the proximal end of tube 178 to catch embolic material.
  • Struts 184 can also be formed of an appropriate polymer material.
  • FIG. 16A illustrates distal protection device 192 .
  • Device 192 includes guidewire 194 , actuator wire 196 , and filter assembly 198 .
  • Filter assembly 198 includes an expandable ring 200 , such as an expandable polymer or metal or other elastic material, which has attached thereto mesh 202 .
  • Mesh 202 is also attached to guidewire 194 distally off ring 200 .
  • Actuator wire 196 is attached to sleeve or sheath 204 which is positioned to fit about the outer periphery of expandable ring 200 , when expandable ring 200 is in the collapsed position.
  • expandable ring 200 when sheath 204 is moved distally of expandable ring 200 , expandable ring 200 has shape memory which causes it to expand into the position shown in FIG. 16A.
  • actuator wire 196 when sheath 204 is pulled proximally by pulling, actuator wire 196 relative to guidewire 194 , sheath 204 collapses ring 200 and holds ring 200 in the collapsed position within sheath 204 .
  • Manipulating wires 194 and 196 relative to one another causes device 192 to move from the depoyed position to the collapsed position, and vice versa.
  • FIG. 16B is similar to device 192 except that, instead of having an expandable ring 200 connected at one point to wire 194 , distal protections device 206 includes expand able member 208 which is formed of an elastic coil section of wire 194 .
  • elastic coil section 208 has a shape memory which causes it to expand into the generally helical conical shape shown in FIG. 16B.
  • sheath 204 is pulled proximally relative to expandable member 208 , this causes sheath 204 to capture and retain expandable member 208 in a collapsed position.
  • expandable member 208 returns to its expanded position shown in FIG. 16B carrying with it mesh 210 into a deployed position.
  • sheath 204 is formed of a suitable polymer material and expandable member 208 and expandable ring 200 are preferably formed of Nitinol.
  • FIGS. 17A and 17B illustrate the operation of another distal protection device 212 .
  • Protection device 212 includes guidewire 214 and filter assembly 216 .
  • filter assembly 216 includes a wire braid portion 218 which extends from a distal region: of guidewire 214 proximally thereof.
  • Braid portion 218 is formed of braided filaments or fibers which have a shape memory causing them to form a deployed, basket shaped filter, such as that shown in, FIG. 17A, in the unbiased position.
  • Braided portion 218 terminates at its proximal end in a plurality of eyelets 220 .
  • One or more cinch wires, 222 are preferably threaded through eyelets 220 .
  • FIG. 17B shows distal protection device 212 except that in the embodiment shown in FIG. 17B, protection device 212 is not disposed distally of the stenosis, but rather proximally. This results, for example, in an application where the blood flow is proximal of the stenosis rather than distal.
  • guidewire 214 is preferably hollow and the cinch wire 222 extends through the lumen therein. By pushing on guidewire 214 , a force is exerted on mesh 218 in the distal direction. This causes cinch wire 222 to tightly close the distal opening in filter assembly 216 and to collapse mesh portion 218 .
  • mesh port ion 218 expands and filter assembly 216 is deployed as shown in FIG. 17B.
  • FIGS. 18A and 18B illustrate a distal protection device 250 in accordance with another aspect of the present invention.
  • Device 250 includes inner wire 252 and outer tube 254 .
  • inner wire 252 is a core wire and outer tube 254 has a lumen 256 therein large enough to accommodate longitudinal movement of inner wire 252 therein.
  • inner wire 252 has, coupled to its distal end 258 , a spring tip 260 .
  • Device 250 includes expandable mesh or braid portion 262 .
  • Expandable portion 262 has a proximal end 264 which is attached to the distal end 266 of tube 254 .
  • expandable member 262 has a distal end 268 which is attached to the distal end 258 of inner wire 252 .
  • Expandable member 262 is preferably a mesh or braided material which is coated with polyurethane.
  • a distal portion of expandable member 262 has a tighter mesh than a proximal portion thereof, or has a microporous membrane or other suitable filtering mechanism disposed thereover.
  • expandable member 262 is simply formed of a tighter mesh or braided material which, itself, forms the filter.
  • FIG. 18A illustrates device 250 in a collapsed, or insertion position wherein the outer diameter of mesh portion 262 closely approximates the outer diameters of either inner wire 252 or outer tube 254 .
  • FIG. 18B illustrates device 250 in the deployed position in which expandable member 262 is radially expanded relative to the collapsed position shown in FIG. 18A.
  • the outer tube 254 is moved distally with respect to inner wire 252 such that the distal ends 266 and 258 of wires 254 and 252 move longitudinally toward one another. Relative movement of ends 266 and 258 toward one another causes the mesh of expandable member 262 to buckle and fold radially outwardly.
  • the outer diameter of expandable member 262 in the deployed position shown in FIG. 18B closely approximates the inner diameter of a vessel within which it is deployed.
  • FIG. 18C illustrates, device 250 in a partially collapsed position.
  • the distal end 266 of outer tube 254 and the distal end 258 of inner wire 252 are moved even closer together than they are as shown in FIG. 18B.
  • This causes expandable mesh portion 262 to fold over itself and form a rolling, proximally directed flap 270 .
  • mesh portion 262 continues to fold over itself such that the rolling flap portion 270 has an outer radial diameter which continues to decrease.
  • expandable mesh portion 262 continues to fold over itself and to collapse over the outer periphery of outer tube 254 .
  • FIG. 18D illustrates device 250 in a fully collapsed position in which it retains emboli captured therein.
  • the distal end 266 of outer tube 254 has been advanced as far distally as it can relative to the distal end 258 of inner wire 252 .
  • Device 250 thus captures any emboli filtered from the vessel within which it was deployed, and can be removed while retaining that embolic material.
  • FIG. 19 illustrates device 280 which depicts a further aspect in accordance with the present invention.
  • Device 280 includes outer tube 282 , core wire 284 , transition tube 286 , movable plunger 288 , expandable member 290 , fixed collar 292 and bias member 294 .
  • tube 282 comprises a proximal hypotube which is coupled to a plunger that selectively provides fluid under pressure through an inflation lumen 296 .
  • Inner wirer 284 is preferably a tired core wired which terminates at its distal end in a spring coil tip 298 and which is coupled at its proximal end 300 to transition tube 286 .
  • Transition tube 286 is preferably an outer polymer sleeve either over hypotube 282 , or simply disposed by itself and coupled to a hypotube 282 . Transition tube 286 is capable of withstanding the inflation pressure provided by the fluid delivered through the inflation lumen 296 .
  • Movable collar 288 is preferably slidably engageable with the interior surface of transition tube 286 and with the exterior surface of core wire 284 , and is longitudinally movable relative thereto.
  • Slidable collar 288 has, attached at its distal end, bias spring 294 which is preferably coiled about core wire 284 and extends to fixed collar 292 .
  • Fixed collar 292 is is preferably fixedly attached to the exterior surface of a distal portion of core wire 284 .
  • Expandable member 290 is preferably formed, at a proximal portion thereof, of either discrete struts, or another suitable frame (such as a loose mesh).which allows blood and embolic material to flow therethrough.
  • the proximal end 302 of expandable member 290 is coupled to distal region of movable collar 288 .
  • the distal portion of expandable member 290 is preferably formed of a filtering material which is suitable for allowing blood flow therethrough, but which will capture embolic material being carried by the blood.
  • spring 294 biased to force collars 288 and 292 away from one another.
  • collar 288 retracts within transition tube 286 pulling expandable member 290 into a collapsed position about core wire 284 .
  • the operator in order to deploy collapsible member 290 as shown in FIG. 19, the operator preferably actuates a plunger (not shown) which delivers pressurized fluid through lumen 296 .
  • the pressurized fluid enters transition tube 286 and travels about the outer periphery of inner core wire 284 , thus forcing movable collar 288 to move distally along core wire 284 .
  • This overcomes the spring force exerted by spring 294 thus causing collars 28 B and 292 to move toward one another, relatively.
  • This motion causes expandable member 290 to buckle and expand outwardly to the deployed position shown in FIG. 19.
  • Expandable member 290 is collapsed by releasing the pressure applied through lumen 296 (i.e., by causing the plunger to move proximally). This allows spring 294 to again urge collars 288 and 292 away from one another to collapse expandable member 290 .
  • the frame supporting expandable member 290 is a imparted with a memory (such as a heat set, or a thermally responsive material which assumes a if memory upon reaching a transition temperature) such that the resting state of the frame supporting expandable member 290 is in a collapsed position. This eliminates the need for spring 294 .
  • the expandable member 290 in that preferred embodiment, is expanded using the hydraulic pressure provided by the pressurized fluid introduced through lumen 296 and it is collapsed by simply allowing the memory in expandable member 290 to force fluid from transition tube 286 back through lumen 296 .
  • FIGS. 20A and 20B illustrate another aspect in: accordance with the present invention.
  • a device 310 includes a mesh portion 312 supported by a frame 314 . Expansion of frame 314 to the radially expanded position shown in FIG. 20A, is driven by an expandable member, such as a balloon, 316 which is coupled to frame 314 . Balloon 316 is coupled to a distal end of a distal hypotube 318 , which is formed of a suitable material, such as Nitinol. It should be noted that the distal tip of hypotube 318 includes a spring tip 320 .
  • Distal hypotube 318 is shown coupled to a proximal hypotube 322 which has a tapered portion 324 therein.
  • proximal hypotube 322 is formed of a suitable material, such as stainless steel.
  • a plunger 326 is longitudinally movable within the lumen of both proximal hypotube 322 and distal hypotube 318 .
  • Frame 314 , and consequently mesh portion 312 are deployed by the operator moving plunger 326 distally within the lumens of hypotubes 318 and 322 .
  • This causes pressurized fluid to enter balloon 316 , thereby inflating balloon 316 and driving deployment of frame 314 and mesh 312 .
  • the operator preferably moves plunger 326 proximally within the lumens of tubes 318 and 322 to withdraw fluid from within balloon 316 .
  • mesh 312 or frame 314 can have a memory set which is either in the inflated or collapsed position such that the operator need only affirmatively move frame 314 and mesh 312 to either the deployed or collapsed position, whichever is opposite of the memory set.
  • device 310 includes a flocking region 328 .
  • FIG. 20B illustrates locking region 328 in greater detail.
  • FIG. 20B illustrates that in lockings region 328 , plunger 326 has a plurality of grooves 330 formed in the outer radial surface thereof.
  • FIG. 20B illustrates that one of hypotubes 318 or 322 has an inwardly projecting portion 332 .
  • inwardly projecting portion 332 includes an inwardly extending, deflectable, annular rim which extends inwardly from either hypotube 318 or 322 .
  • the inwardly projecting portion 332 includes a plurality of discrete fingers which extend inwardly from one of hypotubes 318 or 322 and which are angularly displaced about the interior periphery of the corresponding hypotube 318 or 322 .
  • inwardly projecting portion 332 rides along the exterior periphery of plunger 326 until it encounters one of grooves 330 . Then, inwardly projecting portion 332 snaps into the groove 330 to lock plunger 326 longitudinally relative to tubes 318 and 322 .
  • both inwardly projecting portions 332 and, grooves 330 are formed such that, when gentle pressure is exerted by the operator on plunger 326 relative to hypotubes 318 and 322 , projection portions 332 follow the contour of grooves 330 up and out of grooves 330 so that plunger 326 can again be freely moved within the lumens of hypotubes 318 and 322 .
  • the relative interaction between projecting portions 332 and grooves plurality longitudinal positions relative hypotubes 318 and 322 , since a plurality of grooves 330 are provided.
  • Plunger 326 can be moved back :and forth longitudinally within the lumens of hypotube 318 and 322 in a ratcheting manner, and can be locked into one of a plurality of relative longitudinal positions because there are a plurality of grooves 330 in the exterior of plunger 326 . It should also be noted, however, that in another preferred embodiment, a plurality of sets of inwardly projecting portions 332 are provided along the inner longitudinal surface of hypotubes 318 and/or 322 . In that case, only a single groove 330 needs to be formed in the exterior surface of plunger 326 ; and the same type of ratcheting locking operation is obtained.
  • hypotubes 318 and 322 are tapered. This allows device 310 to maintain increased flexibility. It should also be noted that, in the preferred embodiment, hypotubes 318 and 322 are, preferably sized as conventional guidewires.
  • FIG. 21A illustrates a protection device in accordance with another embodiment of the present invention.
  • FIG. 21A illustrates distal protection device 340 .
  • Device 340 is similar to devices 192 and 206 shown in FIGS. 16A and 16B.
  • device 340 includes hoop-shaped frame 342 , filter portion 344 , and wire. 346 .
  • Hoop-shaped frame 342 is preferably a self-expanding frame formed of a wire which includes a shape memory alloy.
  • hoop-shaped frame 342 is formed of a nitinol wire having a diameter in a range of approximately 0.002-0.004 inches.
  • Filter portion 344 is preferably formed of a polyurethane material having holes therein such that blood flow can pass through filter 344 , but emboli (of desired size) cannot pass through filter 344 but are retained therein.
  • filter material 344 is attached to hoop-shaped frame 342 with a a suitable, commercially available adhesive.
  • filter 344 has a proximal portion thereof folded over hoop-shaped frame 342 , and the filter material is attached itself either with adhesive, by stitching, or by another suitable connection mechanism, in order to secure it about hoop-shaped frame 342 .
  • This connection is preferably formed by a suitable adhesive or other suitable connection mechanism.
  • the distal end of filter 344 is preferably attached about the outer periphery of wire 346 , proximate coil tip 348 on wire 346 .
  • filter 344 is approximately 15 mm in longitudinal length, and has a diameter at its mouth (defined by hoop-shaped frame 342 ) of a conventional size (such as 4.0 mm, 4.5 mm, 5 mm, 5.5 mm, or 6 mm). Of course, any other suitable size can be used as well.
  • a conventional size such as 4.0 mm, 4.5 mm, 5 mm, 5.5 mm, or 6 mm.
  • any other suitable size can be used as well.
  • filter 344 is formed of a polyurethane material with the holes laser drilled therein.
  • the holes are preferably approximately 100 ⁇ m in diameter.
  • filter 344 can also be a microporous membrane, a wire or polymer braid or mesh, or any other suitable configuration.
  • Wire 346 is preferably a conventional stainless steel guidewire having conventional guidewire dimensions.
  • wire 346 is a solid core wire having tan outer diameter of approximately 0.014 inches and an overall length of up to 300 cm.
  • wire 346 has a distal end 350 , in a region proximate filter 344 , which tapers form an outer diameter at its proximal end which is the same as the outer diameter of the remainder of wire 346 , to an outer diameter of approximately 0.055 inches at its distal end.
  • guidewire 346 is preferably formed of stainless steel 304 .
  • guidewires having an outer diameter of approximately 0.018 inches may also be used.
  • different dimensions may also be used, such as outer diameters of approximately 0.010 inches to 0.014 inches.
  • wire 346 will vary with application. Applications involving neural vasculature will require the use of a smaller guidewire, while other applications will require the use of a larger guidewire.
  • wire 346 can be replaced by a hollow guidewire, or hypotube of similar, or other suitable dimensions.
  • radiopaque loaded powder can be used to form a polyurethane sheath which is fitted over wire 346 or hoop 342 , or which is implemented in filter 344 .
  • hoop 342 and wire 346 can be gold plated in order to increase radiopacity.
  • marker bands can be used on wire 346 or filter 344 to increase the radiopacity of the device.
  • hoop 342 (and thus filter 344 ) is preferably collapsed to a radially contracted diameter of wire 346 . Methods of performing this contraction are described later in the specification.
  • wire 346 is manipulated to position hoop 342 and filter 344 distal of a restriction to be treated. Then, the restraining force which is used to restrain hoop 342 in the predeployment, low profile position is removed, and the super elastic properties of nitinol hoop 342 (or the shape memory properties of another shape memory alloy) are utilized in allowing hoop 342 to assume its shape memory position. This causes hoop 342 to define a substantially lumen filling mouth to filter 344 which is positioned distal of the restriction to be treated.
  • a suitable dilatation device is then advanced over wire 346 and is used to treat the vascular restriction. Emboli which are carried by blood flow distal of the restriction are captured by filter 344 . After the dilatation procedure, filter 344 , along with the emboli retained therein, are retrieved from the vasculature. Various retrieval procedures and devices are described later in the specification.
  • hoop-shaped frame 342 By allowing hoop-shaped frame 342 to be unattached to wire 346 , and only connected to wire 346 through filter 344 (or other super structure used to support filter 344 ), wire 346 is allowed to substantially float within hoop 342 .
  • This configuration provides some advantages. For instance, hoop 342 can better follow the vasculature without kinking or prolapsing (i.e., without collapsing upon itself). Thus, certain positioning or repositioning of filter 344 can be accomplished with less difficulty.
  • FIG. 21B illustrates a protection device 352 in accordance with another embodiment of the present invention.
  • Protection device 352 is similar to protection device 340 , and similar items are similarly numbered. However, rather than having simply a hoop-shaped frame 342 to support filter 344 , and drive filter 344 into its expanded and deployed position device 352 includes frame 354 which includes a hoop-shaped portion 356 , and a pair of tails 358 and 360 .
  • Tails 358 and 360 extend proximally from hoop-shaped portion 356 to an attachment region 362 in the preferred embodiment, tails 358 and 360 are attached to wire 346 at attachment region 362 by soldering, welding, brazing, adhesive, or any other suitable attachment mechanism.
  • attachment sleeve 364 formed of a weldable material, is attached at its inner periphery to tails 358 and 360 . Sleeve 364 is then attached, using welding or brazing to wire 346 .
  • tails 358 and 360 frame 354 is directly connected to wire 346 .
  • tails 358 and 360 are provided so that the point of attachment of frame 354 to wire 346 is located several millimeters proximal of hoop-shaped portion 356 . This provides some additional structural integrity to frame 354 , but still allows frame 354 to substantially float about wire 346 in the region of hoop-shaped frame portion 356 .
  • FIG. 21C illustrates a protection device 366 in accordance with another embodiment of the present invention.
  • Protection device 366 is similar to protection devices 340 and 352 shown in FIGS. 21A and 21B, and similar items are similarly numbered.
  • device 366 includes hoop-shaped frame 368 .
  • Frame 368 is similar to frame 342 shown in FIG. 21A.
  • hoop 368 does not allow wire 346 to float freely therein. Instead, hoop 368 is directly attached to wire 346 at attachment point 370 . This causes hoop-shaped frame 368 and filter 344 to reside eccentrically about wire 346 .
  • FIGS. 22 A- 22 C illustrate one preferred embodiment for delivering one of devices 340 , 352 and 366 .
  • device 352 is illustrated in FIGS. 22 A- 22 C.
  • FIG. 22A illustrates delivery device 372 .
  • delivery device 372 includes proximal hub 374 , shaft 376 , and distal retaining section 378 .
  • device 372 also includes marker band 380 .
  • delivery device 372 is similar to a conventional balloon catheter in that proximal hub 374 is a conventional hub, and shaft 376 is a conventional balloon catheter shaft.
  • distal retaining section 378 is preferably a conventional angioplasty balloon having an inflated diameter of approximately 1.5-2.0 millimeters, but having its distal end cutoff such that the distal end 382 of balloon 378 is open.
  • hoop-shaped frame 354 Prior to insertion of device 372 into the vasculature, hoop-shaped frame 354 is retracted into its low profile deployment position and is withdrawn through end 382 , into balloon 378 . Then, the distal end of balloon 378 is exposed to heat to heat shrink or heat set the distal end of balloon 378 around the radially retracted device 352 .
  • Device 372 including device 352 , is then inserted in the vasculature either through a preplaced guide catheter, along with a guide catheter, or simply without a guide catheter utilizing coil tip 348 .
  • distal protection device 352 is then removed from within heat collapsed balloon 378 .
  • the physician simply accomplishes longitudinal movement of wire 346 relative to catheter 376 .
  • the physician may simply hold wire 346 longitudinally in place and withdraw catheter 376 proximally relative to wire 346 by pulling on hub 374 . This causes balloon 378 to move proximally relative to device 352 , and thereby to expose device 352 to the vasculature.
  • FIG. 22B illustrates another preferred embodiment for removing device 352 from within balloon 378 .
  • syringe 384 which contains fluid, is inserted into coupling 386 in hub 374 .
  • the physician then introduces pressurized fluid into the lumen of catheter 376 .
  • the pressurized fluid advances down the lumen of catheter 376 to the distal end where it encounters collapsed balloon 378 .
  • the pressure exerted on balloon 378 by the pressurized fluid causes balloon 378 to open radially.
  • the physician withdraws catheter 376 relative to device 352 thereby exposing device 352 to the vasculature.
  • device 352 assumes its shape memory position in the vasculature, as illustrated in FIG. 22C.
  • device 352 substantially forms a lumen-filling basket or filter which allows blood to pass distally therethrough, but which retains or captures embolic material carried by the blood flow.
  • the physician then simply removes device 372 from the vasculature, leaving device 352 in place during subsequent procedures.
  • shaft 376 includes a predefined slit or score from a region just proximal of marker band 380 to, or through, hub 374 . Thus, as the physician removes device 372 , it can be peeled away from device 352 .
  • device 372 can be provided with an aperture in shaft 376 near its distal end.
  • the proximal end of wire 346 will thus lie outside of shaft 376 .
  • Wire 346 can enter shaft 376 through the aperture and extend through the distal end of shaft 376 . This also facilitates easier withdrawal of device 372 over wire 346 .
  • FIGS. 23 A- 23 E illustrate one preferred embodiment for retrieving one of the devices 340 , 352 and 366 described in FIGS. 21 A- 21 C. For the sake of clarity, only device 352 is illustrated in FIGS. 23 A- 23 E.
  • FIG. 23A illustrates retrieval device 388 .
  • Retrieval device 388 is preferably formed of proximal shaft 390 , mesh portion 392 , and end cap 394 . Items 390 , 392 and 394 preferably each have lumens therein to define a passageway for receiving wire 346 .
  • wire 346 may optionally be provided with an positive stop 396 (which can be embodied as a radiopaque marker band)
  • Optional stop 396 may also simply be an annular ring attached to wire 346 proximate to filter 344 , or may be any other suitable stop.
  • Proximal shaft 390 is preferably simply a polymer or nitinol tube sized and configured to track over wire 346 .
  • End cap 394 is also preferably formed to track over wire 346 , but also contains radiopaque material to serve as a distal marker band for retrieval device 388
  • mesh 392 is preferably a braid or mesh formed of wire or polymer material having sufficient flexibility that it can be deflected as described below.
  • Mesh 392 preferably has a proximal end coupled to proximal shaft 390 , by adhesive, welding, or other suitable attachment mechanisms.
  • Mesh 392 also preferably includes a distal end connected to end cap 394 , also by a suitable connection mechanism.
  • device 380 In order to retrieve filter 344 , which likely contains embolic materials, device 380 is inserted in the low profile position shown in FIG. 23A, over wire 346 , to apposition proximate filter 344 . Then, device 388 is advanced toward filter 344 , until end cap 394 abuts positive stop 396 ; or the hoop-shaped frame 354 . Continued advancement of proximal shaft 390 relative to wire 346 causes compression of mesh 392 . This results in a radial expansion of an intermediate portion of mesh 392 (between the proximal and distal ends of mesh 392 ). The radial expansion of mesh portion 392 is illustrated in FIG. 23B.
  • the intermediate portion of mesh 392 is configured to bend over on itself such that it is axially displaced toward filter 344 , in the direction generally indicated by arrows 398 in FIG. 23C.
  • mesh 392 is sized and configured such that, with continued advancement of proximal shaft 390 relative to wire 346 , this action continues as shown in FIGS. 23D and 23E until the intermediate portion of mesh 392 encompasses at least the mouth of filter 344 .
  • the intermediate portion of mesh 392 when driven as described above, engages and contracts the mouth of filter 344 to a lower profile position, such as that shown in FIG. 23E.
  • mesh 392 is sized and configured to substantially engulf the entire filter 344 .
  • device 388 are simply withdrawn from the vasculature.
  • devices 388 and 352 are simply withdrawn either into the guide catheter and the guide catheter is removed with those devices simultaneously or devices 388 and 352 are removed from the guide catheter prior to removal of the guide catheter.
  • no guide catheter devices 388 and 352 are simply removed from the vasculature simultaneously.
  • a second actuation tube or wire can also be provided which is attached to end cap 394 , and which extends back through the lumen in proximal tube 390 and is longitudinally movable relative to proximal shaft 390 .
  • the actuation wire or elongate member can be used to pull cap 394 closer to the distal portion of proximal shaft 390 in order to accomplish the action illustrated in FIGS. 23 A- 23 E.
  • FIGS. 18 A- 21 D illustrate the mesh portion folded proximally rather than distally.
  • FIGS. 24 A- 24 C illustrate another preferred embodiment in accordance with the present invention, for retrieving any of the distal protection devices 340 , 352 or 366 shown in FIGS. 21 A- 21 C. For the sake of clarity, only device 352 is illustrated in FIGS. 24 A- 24 C.
  • FIG. 24A illustrates retrieval device 400 .
  • Retrieval device 400 preferably includes retrieval sheath 402 , proximal locking device 404 , dilator sheath 405 and nose cone 406 .
  • retrieval sheath 402 is preferably formed of polyether block amide (PEBAX) material having an outer diameter of approximately six French (i.e., approximately 2 mm) and having a shore D hardness of approximately 40 .
  • retrieval sheath 402 preferably has a wall thickness of approximately 0.004 inches.
  • Dilator sheath 405 , and nose cone 406 are preferably formed of low density polyethylene, or high density polyethylene.
  • Sheath 405 preferably has an: outer diameter which is approximately equal to the inner diameter of sheath 402 .
  • the inner diameter of sheath 405 and in cone 406 is preferably just large enough to fit over, and track over, wire 346 .
  • Nose cone 406 preferably has a proximal portion which is either attached to, or formed integrally with, sheath 405 .
  • the outer diameter of the proximal portion of nose cone 406 is also approximately the same as the outer diameter of sheath 405 .
  • nose cone 406 also preferably has a distal portion which tapers, or reduces along preferably a smooth curve, to an outer diameter which terminates at the inner diameter of nose cone 406 .
  • Proximal locking device 404 is preferably any suitable, and commercially available, locking device which can be configured to lock dilator sheath 405 to guidewire 346 .
  • device 400 In order to retrieve .device 352 from the vasculature, device 400 is preferably advanced over guidewire 346 to a position shown in FIG. 24B, in which the distal portion of nose cone 406 is closely proximate, or adjacent to, either optional stop 396 or the mouth of filter 344 . Then, proximal locking devil 404 is actuated to lock dilator sheath 405 to wire 346 so that wire 346 and dilator sheath 405 (as well as nose cone 406 ) can be moved as a unitary piece.
  • wire 346 (and hence dilator sheath 405 and nose cone 406 ) are withdrawn longitudinally relative to retrieval sheath 402 .
  • This causes the mouth of filter 344 to enter within the distal opening in retrieval sheath 402 .
  • wire 346 dilator sheath 405 and nose cone 406 can be withdrawn further into sheath 402 such that the entire filter 344 , and wire tip 348 , are disposed within the lumen of sheath 402 .
  • device 352 is configured to be removed from the vasculature. This can be accomplished by either removing dilator sheath 405 , nose cone 406 and device 352 as a unitary piece, leaving sheath 402 in place for later removal, or by removing sheath 402 with the remainder of the system, either through a guide catheter or simply through the vasculature, simultaneously. Also, where a guide catheter is used, device 352 and device 400 can be removed through the guide catheter leaving the guide catheter in place, or the guide catheter can be removed simultaneously with the other devices 352 and 400 .
  • all of the devices according to the present invention can optionally be coated with an antithrombotic material, such as heparin (commercially available under the trade name Duraflow from Baxter), to inhibit clotting.
  • an antithrombotic material such as heparin (commercially available under the trade name Duraflow from Baxter), to inhibit clotting.
  • the super elastic properties of nitinol are used to form a frame at least in the area of the: mouth of the distal protection filter.
  • the distal protection device can be deployed, retrieved, and redeployed any number of times without incurring plastic deformation.
  • various deployment and retrieval techniques and systems are .provided which address various problems associated with such systems.

Abstract

An emboli capturing system captures emboli in a body lumen. A first elongate member has a proximal end and a distal end. An expandable emboli capturing device is mounted proximate the distal end of the first elongate member, and is movable between a radially expanded position and a radially contracted position. When in the expanded position, the emboli capturing device forms a basket with a proximally opening mouth. A second elongate member has a proximal and a distal end with a lumen extending therebetween. The lumen is sized to slidably receive a portion of the first elongate member. An expandable delivery device is mounted to the distal end of the second elongate member and is movable from a radially retracted position to a radially expanded position. The delivery device has a receiving, end configured to receive the emboli capturing device, and retains at least the mouth of the emboli capturing device in a radially retracted position.

Description

    INCORPORATION BY REFERENCE
  • This application is a continuation-in-part of co-pending application Ser. No. 08/810,825 filed Mar. 6, 1997 entitled DISTAL PROTECTION DEVICE, and assigned to the same assignee as the present invention. [0001]
  • The following co-pending patent application is hereby incorporated by reference U.S. patent application Ser. No. 08/813,794, entitled DISTAL PROTECTION DEVICE which was filed on Mar. 6, 1997, and assigned to the same assignee as the present application.[0002]
  • BACKGROUND OF THE INVENTION
  • The present invention deals with an emboli capturing system. More specifically, the present invention deals with an emboli capturing system and method for capturing embolic material in a blood vessel during an atherectomy or thrombectomy procedure. [0003]
  • Blood vessels can become occluded (blocked) or stenctic (narrowed) in one of a number of ways. For instance, a stenosis may be formed by an atheroma which is typically a harder calcified substance which forms on the lumen walls of the blood vessel. Also, the stenosis can be formed of a thrombus material which is typically much softer than an atheroma, but can nonetheless cause restricted blood flow in the lumen of the blood vessel. Thrombus formation can be particularly problematic in a saphenous vein graft (SVG). [0004]
  • Two different procedures have, developed to, treat a stenotic lesion (stenosis) in vasculature. The first is to deform the stenosis to reduce the restriction within the lumen of the blood vessel. This type of deformation (or dilatation) is typically performed using balloon angioplasty. [0005]
  • Another method of treating stenotic vasculature is to attempt to completely remove either the entire stenosis, or enough of the stenosis to relieve the restriction in the blood vessel. Removal of the stenotic lesion has been done through the use of radio frequency (RF) signals transmitted via conductors, and through the use of lasers, both of which treatments are meant to ablate (i.e., super heat an vaporize) the stenosis. Removal of the stenosis has also been accomplished using thrombectomy or atherectomy. During thrombectomy and atherectomy, the stenosis is mechanically cut or abraded away from the vessel. [0006]
  • Certain problems are encountered during thrombectomy and atherectomy. The stenotic debris which separated from the stenosis is; free to flow within the lumen of the vessel. If the debris flows distally, it can occlude distal vasculature and cause significant problems. If it flows proximally, it can enter the circulatory system and form a clot in the neural vasculature, or in the lungs, both of which are highly undesirable. [0007]
  • Prior attempts deal with the debris or fragments have included cutting the debris into such small pieces (having a size on the order of a blood cell) that they will not occlude vessels within the vasculature. However, this technique has certain problems. For instance, it is difficult to control the size of the fragments of the stenotic lesion which are severed. Therefore, larger fragments can be severed accidentally. Also, since thrombus is much softer than an atheroma, it tends top break up easier when mechanically engaged by a cutting instrument. Therefore, at the moment that the thrombus is mechanically engaged, there is a danger that it can be dislodged in large fragments which would occlude the vasculature. [0008]
  • Another attempt to deal with debris severed from a stenosis is to remove the debris, as it is severed, using suction. However, it may be necessary to pull quite a high vacuum in order to remove all of the pieces severed from the stenosis. If a high enough vacuum is not used, all of the severed pieces will not be removed. Further, when a high vacuum is used, this can tend to cause the vasculature to collapse. [0009]
  • A final technique for dealing with the fragments of the stenosis which are severed during atherectomy is to place a device distal to the stenosis during atherectomy to catch the pieces of the stenosis as they are severed, and to remove those pieces along with the capturing device when the atherectomy procedure is complete. Such capture devices have included expandable filters which are placed distal of the stenosis to capture stenosis fragments. Problems are also associated with this technique. For, example, delivery of such devices in a low profile, pre-deployment configuration can be difficult. Further, some devices include complex and cumbersome actuation mechanisms. Also, retrieving such capture devices, after they have captured emboli, can be difficult as well. [0010]
  • SUMMARY OF THE INVENTION
  • An emboli capturing system captures emboli in a body lumen. A first elongate member has a proximal fend and a distal end. An expandable emboli capturing device is mounted proximate the distal end of the first elongate member, and is movable between a radially expanded position and a radially contracted position. When in the expanded position, the emboli capturing device forms a basket with a proximally opening mouth. A second elongate member has a proximal and a distal end with a lumen extending therebetween. The lumen is sized to slidably receive a portion of the first elongate member. An expandable delivery device is mounted to the distal end of the second elongate member and is movable from a radially retracted position to a radially expanded position. The delivery device has a receiving end configured to receive the emboli capturing device, and retains at least the mouth of the emboli capturing device in a radially retracted position.[0011]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows a distal protection device of the present invention in a deployed position. [0012]
  • FIG. 2 shows the, distal protection device shown in FIG. 1 in a collapsed position. [0013]
  • FIG. 3 shows an end view of a portion of the distal protection device shown in FIGS. 1 and 2. [0014]
  • FIG. 4 shows a cross sectional view of a portion of the distal protection device shown in FIGS. [0015] 1-3 in the deployed position.
  • FIG. 5 shows a second embodiment of the distal protection device according to the present invention in a deployed position. [0016]
  • FIG. 6 shows an end view of the distal protection device shown in FIG. 5. [0017]
  • FIG. 7 shows a cross sectional view of the distal protection device shown in FIGS. 5 and 6 in then collapsed position. [0018]
  • FIG. 8 shows a third embodiment of a distal protection device according to the present invention in a deployed position. [0019]
  • FIG. 9 is a side sectional view of an alternate embodiment illustrating how the expandable members of the present invention are attached to a guide wire. [0020]
  • FIG. 10 is a sectional view taken along section lines [0021] 10-10 in FIG. 9.
  • FIGS. 11A and 11B show a fourth and fifth embodiment, respectively, of a distal protection device according to the present invention in a deployed position. [0022]
  • FIG. 12 illustrates the operation of a distal protection device in accordance with the present invention. [0023]
  • FIGS. [0024] 13A-17B show additional embodiments of distal protection devices which expand and collapse based on movement of a mechanical actuator.
  • FIGS. [0025] 18A-18D illustrate an additional embodiment of a distal protection device which is deployed and collapsed using a rolling flap configuration.
  • FIG. 19 illustrates another embodiment in accordance with the present invention in which the protection device is deployed using fluid pressure and a movable collar. [0026]
  • FIGS. 20A and 20B illustrate another aspect of the present invention in which two longitudinally movable members used to deploy the distal protection device are disconnectably locked to one another. [0027]
  • FIGS. [0028] 21A-21C illustrate another embodiment in accordance with the present invention in which, the protection device is formed with a shape memory alloy frame and an attached filter or mesh mounted to the frame.
  • FIGS. [0029] 22A-22C illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21A-21C are delivered and deployed.
  • FIGS. [0030] 23A-23E illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21A-21C are retrieved.
  • FIGS. [0031] 24A-24C illustrate another embodiment in accordance with the present invention in which the distal protection devices shown in FIGS. 21A-21C are retrieved.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • FIG. 1 illustrates [0032] protection device 10 in a deployed position within the lumen of a blood vessel 12. Protection device 10 preferably includes hollow. guidewire 14 (or a hypotube having the same general dimensions as a guidewire) having a coil tip 16, and a capturing assembly 18. Capturing assembly 18, in the embodiment shown in FIG. 1, includes an inflatable and expandable member 20 and mesh 22.
  • An interior of [0033] expandable member 20 is preferably coupled for fluid communication with an inner lumen of guidewire 14 at a distal region of guidewire 14. When deployed, inflatable member 20 inflates and expands to the position shown in FIG. 1 such that capturing assembly. 18 has an outer periphery which approximates the inner periphery of lumen 12.
  • [0034] Mesh 22 is preferably formed of woven or braided fibers or wires, or a microporous membrane, or other suitable filtering or netting type material. In one preferred embodiment, mesh 22 is a microporous membrane having holes therein with a diameter of approximately 100 μm. Mesh 22 can be disposed relative to inflatable member 20 in a number of different ways For example, mesh 22 can be formed of a single generally cone shaped piece which is secured to the outer or inner A periphery of inflatable member 20. Alternatively, mesh 22 can be formed as a spiral strip which is secured about the outer or inner periphery of inflatable member 20 filling the gaps between the loops of inflatable member 20. Alternatively, mesh 22 can be formed of a number of discrete pieces which are assembled onto inflatable member 20.
  • [0035] Hollow guidewire 14 preferably has a valve 24 coupled in a proximal portion thereof During operation, a syringe is preferably connected to the proximal end of guidewire 14, which preferably includes a fluid hypotube. The syringe is used to pressurize the fluid such that fluid is introduced through the lumen of hollow guidewire 14, through valve 24, and into inflatable member 20. Upon being inflated, inflatable member 20 expands radially outwardly from the outer surface of guidewire 14 and carries mesh 22 into the deployed position shown in FIG. 1. In this way, capturing assembly, or filter assembly, 18 is deployed distally of stenosis 26 so that stenosis 26 can be If severed and fragmented, and so the fragments from stenosis 26 are carried by blood flow (indicated by arrow 28) into the basket or chamber formed by the deployed filter assembly 18. Filter assembly 18 is then collapsed and removed from vessel 12 with the fragments of stenosis 26 contained therein.
  • FIG. 2 illustrates [0036] protection device 10 with filter assembly 18 in the collapse position. Similar items to those shown in FIG. 1 are similarly numbered. FIG. 2 illustrates that mesh 22 is easily collapsible A with inflatable member 20. In order to collapse filter assembly 18, fluid is preferably removed from inflatable member 20 through the lumen of hollow guidewire 14 and through two way valve 24. This can be done using the syringe to pull a vacuum, or using any other type of suitable fluid removal system.
  • [0037] Inflatable member 20 is preferably formed of a material having some shape memory. Thus, when inflatable member 20 is collapsed, it collapses to approximate the outer diameter of hollow guidewire 14. In one preferred embodiment, inflatable member 20 is formed of a resilient, shape memory material such that it is inflated by introducing fluid under pressure through the lumen in hollow guidewire 14 into inflatable member 20. When pressure is released from the lumen in hollow guidewire 14, inflatable member 20 is allowed to force fluid out from the interior thereof through two-way valve 24 and to resume; its initial collapsed position. Again, this results in filter assembly 18 assuming its collapsed position illustrated in FIG. 2.
  • FIG. 3 illustrates a view taken from the distal end of [0038] device 10 with mesh 22 removed for clarity. FIG. 3 shows that, when inflatable member 20 is deployed outwardly, mesh 22 (when deployed between the loops of inflatable member 20) forms a substantially lumen filling filter which allows blood to flow therethrough, but which provides a mechanism for receiving and retaining stenosis fragments carried into mesh 22 by blood flow through the vessel.
  • FIG. 3 also shows that [0039] inflatable member 20 preferably has a proximal end portion 29 which is connected to the outer periphery of guidewire 14. Although end 29 need not be connected to guidewire 14, it is preferably connected using adhesive or any others suitable connection mechanism. By fixedly connecting proximal end portion 29 to guidewire 14, this increases the stability of the filter assembly 18 upon deployment.
  • FIG. 4 is a cross sectional view of a portion of [0040] protection device 10. FIG. 4 shows protection device 10 with filter assembly 18 in the expanded or deployed position. FIG. 4 also better illustrates that guidewire 14 is hollow and has a longitudinal lumen 30 extending therethrough. Longitudinal lumen 30 is connected in fluid communication with an interior of inflatable member 20 through aperture 32 which is provided in the wall of guidewire 14. FIG. 4 also shows that, in one preferred embodiment, a core wire 34 extends through lumen 30 from a proximal end thereof where it is preferably brazed to a portion of a hypotube which may be connected to the proximal portion of guidewire 14. The core wire 34 extends to the distal end of guidewire 14 where it is connected to coil tip 16. In one preferred embodiment, coil tip 16 is brazed or otherwise welded or suitably connected to the distal portion of core wire 34.
  • FIG. 4 further shows that, in the preferred embodiment, [0041] inflatable member 20 inflates to a generally helical, conical shape to form a basket opening toward the proximal end of guidewire 14. FIG. 4 further illustrates, in the preferred embodiment, mesh 22 has a distal portion 38 which is connected to the exterior surface of guidewire 14, at a distal region thereof, through adhesive 36 or any other suitable connection mechanism.
  • FIG. 5 illustrates a second embodiment of a [0042] distal protection device 40 in accordance with the present invention. Device 40 includes hollow guidewire 42, filter assembly 44 and coil tip 16. Filter assembly 44 includes a plurality of inflatable struts 46 and mesh 47. Each strut 46 has a distal end 48 and proximal end 50. Inflatable struts 46 also have an interior which is coupled in fluid communication, through distal end 48 thereof, with the lumen in hollow guidewire 42. Struts 46 are preferably configured such that, upon being inflated, the proximal ends 50 deploy radially outwardly away from the outer surface of hollow guidewire 42 to assume a dimension which approximates the inner dimension of lumen 58 in which they are inserted.
  • [0043] Mesh 47, as with mesh 22 shown in FIG. 1, is deployed either on the outer or inner surface of inflatable struts 46, such that, when the inflatable struts 46 are deployed radially outwardly, mesh 47 forms a generally conical basket opening toward the proximal end of hollow guidewire 42. As with the embodiment shown in FIG. 1, mesh 47 can be applied to either the outer or the inner surface of struts 46. It can be applied to struts 46 as one unitary conical piece which is adhered about distal ends 48 of struts 46 using adhesive (or about the distal end of guidewire 42 using adhesive) and secured to the surface of the struts 46 also using adhesive. Alternatively, mesh 47 can be applied to struts 46 in a plurality of pieces which are individually or simultaneously secured to, and extend between, struts 46.
  • FIG. 6 is an end view of [0044] distal protection device 40 shown in FIG. 5 taken from the distal end of distal protection device 40. When struts 46 are deployed outwardly, mesh 47 forms a substantially lumen-filling filter which allows blood to flow therethrough, but which provides a mechanism for receiving and retaining stenosis fragments from stenosis 56 carried into mesh 47 by blood flow through the vessel.
  • FIG. 7 is a cross sectional view of a portion of [0045] distal protection device 40 shown in FIGS. 5 and 6. FIG. 7 shows filter assembly 44 in the collapsed position in which it approximates the outer diameter of guidewire 42. FIG. 7 also shows that, in the preferred embodiment, the distal ends 48 of struts 46 are in fluid communication with an inner lumen 52 in hollow guidewire 42 through apertures 54 in the wall of guidewire 42.
  • FIG. 8 illustrates another embodiment of a [0046] distal protection device 60 in accordance with the present invention. Distal protection device 60 is similar to those shown in other figures, and similar items are similarly numbered. However, distal protection device 60 includes hollow guidewire 63 which has a lumen in fluid communication with an interior of a pair of inflatable struts 62. Inflatable struts 62 have an inner surface 64 which is generally concave, or hemispherical, or otherwise appropriately shaped such that it extends about a portion of the outer surface of hollow guidewire 63. Mesh portions 66 extend between the inflatable struts 62 so that inflatable struts 62 and mesh portions 66, when deployed outwardly as shown in FIG. 8, form a basket shape which opens toward the proximal end of hollow guidewire 63.
  • FIG. 9 illustrates another system for attaching inflatable struts to a hollow guidewire for a [0047] distal protection device 70 in accordance with the present invention. Distal protection device 70 is similar to the distal protection devices shown in the previous figures in that a plurality of inflatable struts 72 are provided& and preferably have a mesh portion extending therebetween. For the sake of clarity, the mesh portion is eliminated from FIG. 9. However, it will be understood that when deployed distal protection device 70 forms a generally basket-shaped filter assembly which opens toward the proximal end of hollow guidewire 74.
  • In the embodiment shown in FIG. 9, [0048] hollow guidewire 74 has a distal end 75 which is open. An endcap 76 is disposed about the distal end 75 of hollow guidewire 74 and defines an internal chamber or passageway 78. Endcap 76 has a proximal end 80 which has openings therein for receiving the ends of inflatable struts 72. Thus, in order to inflate inflatable struts 72, the operator pressurizes fluid within the lumen of hollow guidewire 74 forcing fluid out through distal end. 75 of hollow guidewire 74, through passageway 78, and into inflatable struts 72. In order to collapse distal protection device 70, the operator draws a vacuum which pulls the fluid back out of inflatable struts 72, through passageway 78 and, if necessary, into the lumen of hollow guidewire 74.
  • FIG. 10 is an end view of [0049] endcap 76 taken along lines 10-10 in FIG. 9. FIG. 10 shows that proximal end 80 of endcap 76 preferably includes a first generally central aperture 82 for receiving the distal end of hollow guidewire 74. Aperture 82 is sized just larger than, or approximating, the outer diameter of hollow guidewire 74 such that it fits snugly over the distal end 75 of hollow guidewire 74. Endcap, 76 is then fixedly connected to the distal end 75 of hollow guidewire 74 through a friction fit, a suitable adhesive, welding, brazing, or another suitable connection technique.
  • FIG. 10 also shows that [0050] proximal end 80 of endcap 76 includes a plurality of apertures 84 which are spaced from one another about end 80. Apertures 84 are sized to receive open ends of inflatable struts 72. In the preferred embodiment, inflatable struts 72 are secured within apertures 84 using a suitable adhesive, or another suitable connection technique. Also, in the preferred embodiment, spring tip 16 is embedded in, or otherwise suitably connected to, endcap 76.
  • FIGS. 11A and 11B show two other preferred embodiments of a distal protection device in accordance with the present invention. FIG. 11A shows [0051] distal protection device 90 which includes hollow guidewire 92 having a lumen running therethrough, inflatable member 94 and mesh portion 96. FIG. 11A shows that inflatable member 94, when inflated, forms a ring about the outer surface of hollow guidewire 92. The ring has an inner periphery 98 which is spaced from the outer surface of hollow guidewire 92 substantially about the entire radial periphery of hollow guidewire 92. Mesh portion extends between the outer surface of hollow guide 92 and the inner periphery 98 of inflatable member 94. Thus, a substantially disc-shaped filter assembly is provided upon deployment of distal protection device 90. As with the other embodiments, deployment of distal protection device 90 is accomplished by providing fluid through the inner lumen of hollow guidewire 92 into an interior of inflatable member 94, which is in fluid communication with the inner lumen of hollow guidewire 92.
  • In one preferred embodiment, end [0052] 100 of inflatable member 94 is coupled to a coupling portion 102 of inflatable member 94 such that, stability is added to inflatable member 94, when it is inflated.
  • FIG. 11B illustrates another [0053] distal protection device 104 which includes a hollow guidewire 106 and an inflatable member 108. Device 104 is similar to distal protection device 90 except that, rather than having only a single inflatable ring upon deployment of distal protection device 104, a plurality of generally equal-diameter rings are formed into a helix shape. In the preferred embodiment, distal protection device 104 includes a mesh sleeve 110 which extends about the outer or inner surface of the helix formed by inflatable member 108. In one embodiment, mesh sleeve 110 is connected to the outer surface of hollow guidewire 106 in a region 112 proximate, but distal of, inflatable member 108. In another preferred embodiment, the proximal end of mesh sleeve 110 is connected to the outer perimeter of inflatable member 108. Thus, distal protection device 104 forms a generally basket shaped filter assembly which opens toward a proximal end of guidewire 106. As with the other embodiments, both distal protection device 90 shown in FIG. 11A and distal protection device 104 shown in FIG. 11B are preferably collapsible. Therefore, when collapsed, the distal protection devices 90 and 104 preferably have an outer dimension which approximates the outer dimension of hollow guidewires 92 and 106, respectively. Further, as with the other embodiments, distal protection devices 90 and 104 can either be biased in the deployed or collapsed positions, and deployment and collapse can be obtained either by pulling a vacuum or pressurizing the fluid within the lumen of the hollow guidewires 92 and 106.
  • FIG. 12 illustrates the use of a distal protection device in accordance with the present invention. For the sake of clarity, the present description proceeds with respect to distal protection, [0054] device 160 only. Device 10 is shown filtering stenosis fragments from the blood flowing through the lumen of vessel 12. FIG. 12 also shows a dilatation device 120 which can be any suitable dilatation device for dilating, cutting, fragmenting, or abrading, portions of stenosis 26. In the preferred embodiment, device 120 is used in an over-the-wire fashion over hollow guidewire 14. Thus, filter assembly 18 is first advanced (using guidewire 14) distal of stenosis 26. Then, filter assembly 18 is deployed outwardly to the expanded position. Dilatation device 120 is then advanced over guidewire 14 to stenosis 26 and is used to fragment or abrade stenosis 26. The fragments are received within the basket of filter assembly 18. Filter assembly 18 is then collapsed, and filter assembly 18 and dilatation device 120 are removed from vessel 12. Alternatively, dilatation device 120 can be removed first and filter assembly 18 is then removed along with guidewire 14.
  • It should be noted that the stenosis removal device (or atherectomy catheter) [0055] 120 used to fragment stenosis 26 can be advanced over guidewire 14. Therefore, the device according to the present invention is dual functioning in that it captures emboli and serves as a guidewire. The present invention does not require adding an additional device to the procedure. Instead, the present invention simply replaces a conventional guidewire with a multi-functional device.
  • FIGS. [0056] 13A-17B illustrate embodiments of various distal protection devices wherein deployment and contraction of the distal protection device is accomplished through a mechanical push/pull arrangement.
  • FIGS. 13A and 13B illustrate a [0057] distal protection device 122. FIG. 13A shows device 122 in an undeployed position and FIG. 13B shows device 122 in a depolyed position. Distal protection device 122 includes a slotted Nitinol tube 124 which has a lumen 126 extending therethrough. Tube 124 has a plurality of slots 128 at a distal region thereof. The distal portion of slots 128 are covered by mesh 130 which, in the preferred embodiment, is a flexible microporous membrane. Device 122 also preferably includes a mandrel 132 which extends through the inner lumen 126 of tube 124 and is attached to the distal end of tube 124. In the preferred embodiment, mandrel 132 is attached to the distal end of tube 124 by an appropriate adhesive, brazing, welding, or another suitable connection technique. Tube 124 also has, on its inner periphery in a proximal region thereof, a plurality of locking protrusions 134. Lock protrusions 134 are preferably arranged about a proximal expandable region 136 disposed on mandrel 132.
  • In order to deploy [0058] device 122 into the deployed position shown in FIG. 13B, the operator preferably first advances tube 124 distally of the lesion to be fragmented. In the preferred embodiment, tube 124 has a size on the order of a guidewire, such as a 0.014 inch outer diameter. Therefore, it easily advances beyond the stenosis to be fragmented. The operator then pushes on the proximal region of tube 124 and pulls on the proximal end of mandrel 132. This causes two things to happen. First, this causes the struts formed by slots 128 to expand radially outwardly, and carry with them, microporous membrane 130. Thus, microporous membrane 130 forms a generally basket shaped filter assembly which opens toward the proximal end of tube 124. In addition, proximal expandable member 136 expands and engages protrusions 134. This locks device 122 in the developed and expanded position. In order to move the device 122 to the collapsed position, the physician simply pushes on mandrel 132 and pulls on the proximal end of tube 124. This causes device 122 to return to the undeployed position shown in FIG. 13A.
  • It should be noted that [0059] device 122 can optionally be provided with a stainless steel proximal hypotube attachment. Also, the struts defined by slots 128 can be expanded and retracted using a fluid coupling instead of a mandrel. In other words, the proximal end of tube 124 can be coupled to a pressurizable fluid source. By making slots 128 very thin, and pressurizing the fluid, the struts expand outwardly. Further, by pulling vacuum on the pressurizable fluid, the struts collapse.
  • FIG. 14A illustrates [0060] distal protection device 140 which is similar to that shown in FIGS. 13A and 13B, except that the struts 142 are formed of a metal or polymer material and are completely covered by mesh 144. Mesh 144 includes two mesh portions, 146 and 148. Mesh portion 146 is proximal of mesh portion 148 on device 140 and is a relatively loose mesh which will allow stenosis fragments to pass therethrough. By contrast, mesh 148 is a fairly tight mesh, or a microporous membrane, (or simply loose mesh portion 146 with a microporous membrane or other suitable filter material bonded or cast or otherwise disposed thereover) which does not allow the fragments to pass therethrough and therefore captures and retains the fragments therein. The mesh portions can provide a memory set which, in the relaxed position, is either deployed or collapsed.
  • FIG. 14B illustrates a [0061] device 150 which is similar to device 140 shown in FIG. 14A, except struts 142 are eliminated and the two mesh portions 146′ and 148′ are simply joined together at a region 152. Also, the two mesh portions 146′ and 148′ are not two different discrete mesh portions but are formed of the same braided mesh material wherein the braid simply has a different pitch. The wider pitch in region 146′ provides a looser mesh, whereas the narrower pitch in region 148′ provides a tighter mesh that traps the embolic material.
  • FIG. 14C illustrates a [0062] distal protection device 160 which is similar to that shown in FIG. 14A. However, rather than simply providing a slotted tube, distal protection device 160 includes a plurality of struts 162 on a proximal region thereof and a plurality of struts 164 on the distal region thereof. Struts 162 are spaced further apart than struts 164 about the periphery of protection device 160. Therefore, struts 162 define openings 166 which are larger than the openings 168 defined by struts 164 and allow stenosis fragments to pass therethrough. Also, struts 164 have secured to the interior surface thereof a filter or mesh portion 170. When deployed, filter portion 170 forms a substantially basket shaped filter device opening toward the proximal region of tube 172.
  • FIG. 15 illustrates the operation of another distal protection device [0063] 176. Distal protection device 176 includes a tube 178 and a push/pull wire 180. Tube 178 has, at the distal end thereof, a filter assembly 182. Filter assembly 182 includes a plurality of preferably metal struts 184 which have a microporous membrane, or other suitable mesh 186 disposed thereon. Tube 178 also preferably includes end cap 188 and umbrella-like expansion structure 190 disposed at a distal region thereof. Expansion structure 190 is connected to the distal region of tube 178 and to metal struts 184 such that, when push/pull wire 180 is pulled relative to tube 178, expansion member 190 exerts a radial, outwardly directed force on struts 184 causing them to expand radially outwardly relative to the outer surface of tube 178. This causes microporous membrane or mesh 186 to be deployed in a manner opening toward the proximal end of tube 178 to catch embolic material. Struts 184 can also be formed of an appropriate polymer material.
  • FIGS. 16A and 16B illustrate a protection device in accordance with another embodiment of the present invention. FIG. 16A illustrates [0064] distal protection device 192. Device 192 includes guidewire 194, actuator wire 196, and filter assembly 198. Filter assembly 198 includes an expandable ring 200, such as an expandable polymer or metal or other elastic material, which has attached thereto mesh 202. Mesh 202 is also attached to guidewire 194 distally off ring 200. Actuator wire 196 is attached to sleeve or sheath 204 which is positioned to fit about the outer periphery of expandable ring 200, when expandable ring 200 is in the collapsed position.
  • Thus, when [0065] sheath 204 is moved distally of expandable ring 200, expandable ring 200 has shape memory which causes it to expand into the position shown in FIG. 16A. Alternatively, when sheath 204 is pulled proximally by pulling, actuator wire 196 relative to guidewire 194, sheath 204 collapses ring 200 and holds ring 200 in the collapsed position within sheath 204. Manipulating wires 194 and 196 relative to one another causes device 192 to move from the depoyed position to the collapsed position, and vice versa.
  • FIG. 16B is similar to [0066] device 192 except that, instead of having an expandable ring 200 connected at one point to wire 194, distal protections device 206 includes expand able member 208 which is formed of an elastic coil section of wire 194. Thus elastic coil section 208 has a shape memory which causes it to expand into the generally helical conical shape shown in FIG. 16B. However, when sheath 204 is pulled proximally relative to expandable member 208, this causes sheath 204 to capture and retain expandable member 208 in a collapsed position. When sheath 204 is again moved distally of expandable member 208, expandable member 208 returns to its expanded position shown in FIG. 16B carrying with it mesh 210 into a deployed position. In the preferred embodiment, sheath 204 is formed of a suitable polymer material and expandable member 208 and expandable ring 200 are preferably formed of Nitinol.
  • FIGS. 17A and 17B illustrate the operation of another [0067] distal protection device 212. Protection device 212 includes guidewire 214 and filter assembly 216. In the preferred embodiment, filter assembly 216 includes a wire braid portion 218 which extends from a distal region: of guidewire 214 proximally thereof. Braid portion 218 is formed of braided filaments or fibers which have a shape memory causing them to form a deployed, basket shaped filter, such as that shown in, FIG. 17A, in the unbiased position. Braided portion 218 terminates at its proximal end in a plurality of eyelets 220. One or more cinch wires, 222 are preferably threaded through eyelets 220. By pushing on guidewire. 214 and pulling on cinch wires 222, the operator is able to cinch closed, and pull proximally, the proximal portion of mesh 218. This causes mesh 218 to collapse tightly about the outer surface of wire 214.
  • Therefore, during operation, the operator holds [0068] mesh 218 in the collapsed position and inserts protection device 212 distally of the desired stenosis. The operator then allows cinch wire 222 to move distally, relative to guidewire 214. This allows mesh 218 to open to the deployed position shown in FIG. 17A which has an outer diameter that approximates the inner diameter of the lumen within which it is disposed. Filter assembly 216 is then disposed to capture embolic material from blood flowing therethrough. Once the embolic material is captured, the operator again moves cinch wire 222 proximally relative to guidewire 214 to collapse filter assembly 216 and capture and retain the embolic material in filter assembly 216. The device 212 is then removed.
  • FIG. 17B shows [0069] distal protection device 212 except that in the embodiment shown in FIG. 17B, protection device 212 is not disposed distally of the stenosis, but rather proximally. This results, for example, in an application where the blood flow is proximal of the stenosis rather than distal. Further, in the embodiment shown in FIG. 17B, guidewire 214 is preferably hollow and the cinch wire 222 extends through the lumen therein. By pushing on guidewire 214, a force is exerted on mesh 218 in the distal direction. This causes cinch wire 222 to tightly close the distal opening in filter assembly 216 and to collapse mesh portion 218. By contrast, by allowing cinch wire 222 to move distal relative to hollow guidewire 214, mesh port ion 218 expands and filter assembly 216 is deployed as shown in FIG. 17B.
  • FIGS. 18A and 18B illustrate a [0070] distal protection device 250 in accordance with another aspect of the present invention. Device 250 includes inner wire 252 and outer tube 254. In the preferred embodiments, inner wire 252 is a core wire and outer tube 254 has a lumen 256 therein large enough to accommodate longitudinal movement of inner wire 252 therein. Also, in the preferred embodiment, inner wire 252 has, coupled to its distal end 258, a spring tip 260.
  • [0071] Device 250 includes expandable mesh or braid portion 262. Expandable portion 262 has a proximal end 264 which is attached to the distal end 266 of tube 254. Also, expandable member 262 has a distal end 268 which is attached to the distal end 258 of inner wire 252.
  • [0072] Expandable member 262 is preferably a mesh or braided material which is coated with polyurethane. In one preferred embodiment, a distal portion of expandable member 262 has a tighter mesh than a proximal portion thereof, or has a microporous membrane or other suitable filtering mechanism disposed thereover. In another preferred embodiment, expandable member 262 is simply formed of a tighter mesh or braided material which, itself, forms the filter. FIG. 18A illustrates device 250 in a collapsed, or insertion position wherein the outer diameter of mesh portion 262 closely approximates the outer diameters of either inner wire 252 or outer tube 254.
  • FIG. 18B illustrates [0073] device 250 in the deployed position in which expandable member 262 is radially expanded relative to the collapsed position shown in FIG. 18A. In order to deploy device 250, the outer tube 254 is moved distally with respect to inner wire 252 such that the distal ends 266 and 258 of wires 254 and 252 move longitudinally toward one another. Relative movement of ends 266 and 258 toward one another causes the mesh of expandable member 262 to buckle and fold radially outwardly. Thus, the outer diameter of expandable member 262 in the deployed position shown in FIG. 18B closely approximates the inner diameter of a vessel within which it is deployed.
  • FIG. 18C illustrates, [0074] device 250 in a partially collapsed position. In FIG. 18C the distal end 266 of outer tube 254 and the distal end 258 of inner wire 252 are moved even closer together than they are as shown in FIG. 18B. This causes expandable mesh portion 262 to fold over itself and form a rolling, proximally directed flap 270. As longitudinal movement of inner wire 252 proximally with respect to outer tube 254 continues, mesh portion 262 continues to fold over itself such that the rolling flap portion 270 has an outer radial diameter which continues to decrease. In other words, expandable mesh portion 262 continues to fold over itself and to collapse over the outer periphery of outer tube 254.
  • FIG. 18D illustrates [0075] device 250 in a fully collapsed position in which it retains emboli captured therein. In FIG. 18D, the distal end 266 of outer tube 254 has been advanced as far distally as it can relative to the distal end 258 of inner wire 252. This causes expandable mesh portion 262 to fold all the way over on itself such that it lies against, and closely approximates the outer diameter of, outer tube 254. Device 250 thus captures any emboli filtered from the vessel within which it was deployed, and can be removed while retaining that embolic material.
  • FIG. 19 illustrates [0076] device 280 which depicts a further aspect in accordance with the present invention. Device 280 includes outer tube 282, core wire 284, transition tube 286 , movable plunger 288, expandable member 290, fixed collar 292 and bias member 294.
  • In the preferred embodiment, tube [0077] 282 comprises a proximal hypotube which is coupled to a plunger that selectively provides fluid under pressure through an inflation lumen 296. Inner wirer 284 is preferably a tired core wired which terminates at its distal end in a spring coil tip 298 and which is coupled at its proximal end 300 to transition tube 286. Transition tube 286 is preferably an outer polymer sleeve either over hypotube 282, or simply disposed by itself and coupled to a hypotube 282. Transition tube 286 is capable of withstanding the inflation pressure provided by the fluid delivered through the inflation lumen 296.
  • [0078] Movable collar 288 is preferably slidably engageable with the interior surface of transition tube 286 and with the exterior surface of core wire 284, and is longitudinally movable relative thereto. Slidable collar 288 has, attached at its distal end, bias spring 294 which is preferably coiled about core wire 284 and extends to fixed collar 292. Fixed collar 292 is is preferably fixedly attached to the exterior surface of a distal portion of core wire 284.
  • [0079] Expandable member 290 is preferably formed, at a proximal portion thereof, of either discrete struts, or another suitable frame (such as a loose mesh).which allows blood and embolic material to flow therethrough. The proximal end 302 of expandable member 290 is coupled to distal region of movable collar 288. The distal portion of expandable member 290 is preferably formed of a filtering material which is suitable for allowing blood flow therethrough, but which will capture embolic material being carried by the blood.
  • In one preferred embodiment, [0080] spring 294 biased to force collars 288 and 292 away from one another. Thus, as spring 294 urges collars 288 and 292 away from one another, collar 288 retracts within transition tube 286 pulling expandable member 290 into a collapsed position about core wire 284. However, in order to deploy collapsible member 290 as shown in FIG. 19, the operator preferably actuates a plunger (not shown) which delivers pressurized fluid through lumen 296. The pressurized fluid enters transition tube 286 and travels about the outer periphery of inner core wire 284, thus forcing movable collar 288 to move distally along core wire 284. This overcomes the spring force exerted by spring 294 thus causing collars 28B and 292 to move toward one another, relatively. This motion causes expandable member 290 to buckle and expand outwardly to the deployed position shown in FIG. 19.
  • [0081] Expandable member 290 is collapsed by releasing the pressure applied through lumen 296 (i.e., by causing the plunger to move proximally). This allows spring 294 to again urge collars 288 and 292 away from one another to collapse expandable member 290. In an alternative embodiment, the frame supporting expandable member 290 is a imparted with a memory (such as a heat set, or a thermally responsive material which assumes a if memory upon reaching a transition temperature) such that the resting state of the frame supporting expandable member 290 is in a collapsed position. This eliminates the need for spring 294. The expandable member 290, in that preferred embodiment, is expanded using the hydraulic pressure provided by the pressurized fluid introduced through lumen 296 and it is collapsed by simply allowing the memory in expandable member 290 to force fluid from transition tube 286 back through lumen 296.
  • FIGS. 20A and 20B illustrate another aspect in: accordance with the present invention. A [0082] device 310 includes a mesh portion 312 supported by a frame 314. Expansion of frame 314 to the radially expanded position shown in FIG. 20A, is driven by an expandable member, such as a balloon, 316 which is coupled to frame 314. Balloon 316 is coupled to a distal end of a distal hypotube 318, which is formed of a suitable material, such as Nitinol. It should be noted that the distal tip of hypotube 318 includes a spring tip 320.
  • [0083] Distal hypotube 318 is shown coupled to a proximal hypotube 322 which has a tapered portion 324 therein. In the preferred embodiment, proximal hypotube 322 is formed of a suitable material, such as stainless steel. A plunger 326 is longitudinally movable within the lumen of both proximal hypotube 322 and distal hypotube 318.
  • Frame [0084] 314, and consequently mesh portion 312, are deployed by the operator moving plunger 326 distally within the lumens of hypotubes 318 and 322. This causes pressurized fluid to enter balloon 316, thereby inflating balloon 316 and driving deployment of frame 314 and mesh 312. In order to collapse frame 314 and mesh 312, the operator preferably moves plunger 326 proximally within the lumens of tubes 318 and 322 to withdraw fluid from within balloon 316. Alternatively, mesh 312 or frame 314 can have a memory set which is either in the inflated or collapsed position such that the operator need only affirmatively move frame 314 and mesh 312 to either the deployed or collapsed position, whichever is opposite of the memory set.
  • In either case, it is desirable that the operator be able to lock [0085] plunger 326 in a single longitudinal position relative to hypotubes 318 land 322. Thus, device 310 includes a flocking region 328.
  • FIG. 20B illustrates locking [0086] region 328 in greater detail. FIG. 20B illustrates that in lockings region 328, plunger 326 has a plurality of grooves 330 formed in the outer radial surface thereof. Also, in accordance with the present invention, FIG. 20B illustrates that one of hypotubes 318 or 322 has an inwardly projecting portion 332. In one preferred embodiment, inwardly projecting portion 332 includes an inwardly extending, deflectable, annular rim which extends inwardly from either hypotube 318 or 322. In another preferred embodiment, the inwardly projecting portion 332 includes a plurality of discrete fingers which extend inwardly from one of hypotubes 318 or 322 and which are angularly displaced about the interior periphery of the corresponding hypotube 318 or 322.
  • In operation, as the operator advances [0087] plunger 326 distally within the lumens of hypotubes 318 and 322, inwardly projecting portion 332 rides along the exterior periphery of plunger 326 until it encounters one of grooves 330. Then, inwardly projecting portion 332 snaps into the groove 330 to lock plunger 326 longitudinally relative to tubes 318 and 322.
  • It should be noted that, in the preferred embodiment, both inwardly projecting [0088] portions 332 and, grooves 330 are formed such that, when gentle pressure is exerted by the operator on plunger 326 relative to hypotubes 318 and 322, projection portions 332 follow the contour of grooves 330 up and out of grooves 330 so that plunger 326 can again be freely moved within the lumens of hypotubes 318 and 322. Thus, the relative interaction between projecting portions 332 and grooves plurality longitudinal positions relative hypotubes 318 and 322, since a plurality of grooves 330 are provided. Plunger 326 can be moved back :and forth longitudinally within the lumens of hypotube 318 and 322 in a ratcheting manner, and can be locked into one of a plurality of relative longitudinal positions because there are a plurality of grooves 330 in the exterior of plunger 326. It should also be noted, however, that in another preferred embodiment, a plurality of sets of inwardly projecting portions 332 are provided along the inner longitudinal surface of hypotubes 318 and/or 322. In that case, only a single groove 330 needs to be formed in the exterior surface of plunger 326; and the same type of ratcheting locking operation is obtained.
  • In the preferred embodiment, at least the exterior of [0089] hypotubes 318 and 322, and preferably the exterior of plunger 326, are tapered. This allows device 310 to maintain increased flexibility. It should also be noted that, in the preferred embodiment, hypotubes 318 and 322 are, preferably sized as conventional guidewires.
  • FIG. 21A illustrates a protection device in accordance with another embodiment of the present invention. FIG. 21A illustrates [0090] distal protection device 340. Device 340 is similar to devices 192 and 206 shown in FIGS. 16A and 16B. However, in the preferred embodiment, device 340 includes hoop-shaped frame 342, filter portion 344, and wire. 346. Hoop-shaped frame 342 is preferably a self-expanding frame formed of a wire which includes a shape memory alloy. In a more preferred embodiment hoop-shaped frame 342 is formed of a nitinol wire having a diameter in a range of approximately 0.002-0.004 inches.
  • [0091] Filter portion 344 is preferably formed of a polyurethane material having holes therein such that blood flow can pass through filter 344, but emboli (of desired size) cannot pass through filter 344 but are retained therein. In one preferred embodiment, filter material 344 is attached to hoop-shaped frame 342 with a a suitable, commercially available adhesive. In another preferred embodiment, filter 344 has a proximal portion thereof folded over hoop-shaped frame 342, and the filter material is attached itself either with adhesive, by stitching, or by another suitable connection mechanism, in order to secure it about hoop-shaped frame 342. This connection is preferably formed by a suitable adhesive or other suitable connection mechanism.
  • Also, the distal end of [0092] filter 344 is preferably attached about the outer periphery of wire 346, proximate coil tip 348 on wire 346.
  • In one preferred configuration, [0093] filter 344 is approximately 15 mm in longitudinal length, and has a diameter at its mouth (defined by hoop-shaped frame 342) of a conventional size (such as 4.0 mm, 4.5 mm, 5 mm, 5.5 mm, or 6 mm). Of course, any other suitable size can be used as well.
  • Also, in the preferred configuration, [0094] filter 344 is formed of a polyurethane material with the holes laser drilled therein. The holes are preferably approximately 100 μm in diameter. Of course, filter 344 can also be a microporous membrane, a wire or polymer braid or mesh, or any other suitable configuration.
  • [0095] Wire 346 is preferably a conventional stainless steel guidewire having conventional guidewire dimensions. For instance, in one embodiment, wire 346 is a solid core wire having tan outer diameter of approximately 0.014 inches and an overall length of up to 300 cm. Also, in the preferred embodiment, wire 346 has a distal end 350, in a region proximate filter 344, which tapers form an outer diameter at its proximal end which is the same as the outer diameter of the remainder of wire 346, to an outer diameter of approximately 0.055 inches at its distal end. At distal region 350, guidewire 346 is preferably formed of stainless steel 304.
  • Of course, other suitable guidewire dimensions and configurations can also be used. For example guidewires having an outer diameter of approximately 0.018 inches may also be used. For other coronary applications, different dimensions may also be used, such as outer diameters of approximately 0.010 inches to 0.014 inches. Further, it will be appreciated that the particular size of [0096] wire 346 will vary with application. Applications involving neural vasculature will require the use of a smaller guidewire, while other applications will require the use of a larger guidewire. Also, wire 346 can be replaced by a hollow guidewire, or hypotube of similar, or other suitable dimensions.
  • In addition, in order to make [0097] wire 342, hoop 346, or filter 344 radiopaque, other materials can be used. For example, radiopaque loaded powder can be used to form a polyurethane sheath which is fitted over wire 346 or hoop 342, or which is implemented in filter 344. Also, hoop 342 and wire 346 can be gold plated in order to increase radiopacity. Also, marker bands can be used on wire 346 or filter 344 to increase the radiopacity of the device.
  • In operation, hoop [0098] 342 (and thus filter 344) is preferably collapsed to a radially contracted diameter of wire 346. Methods of performing this contraction are described later in the specification. Once retracted to a more low profile position, wire 346 is manipulated to position hoop 342 and filter 344 distal of a restriction to be treated. Then, the restraining force which is used to restrain hoop 342 in the predeployment, low profile position is removed, and the super elastic properties of nitinol hoop 342 (or the shape memory properties of another shape memory alloy) are utilized in allowing hoop 342 to assume its shape memory position. This causes hoop 342 to define a substantially lumen filling mouth to filter 344 which is positioned distal of the restriction to be treated.
  • A suitable dilatation device is then advanced over [0099] wire 346 and is used to treat the vascular restriction. Emboli which are carried by blood flow distal of the restriction are captured by filter 344. After the dilatation procedure, filter 344, along with the emboli retained therein, are retrieved from the vasculature. Various retrieval procedures and devices are described later in the specification.
  • By allowing hoop-shaped [0100] frame 342 to be unattached to wire 346, and only connected to wire 346 through filter 344 (or other super structure used to support filter 344), wire 346 is allowed to substantially float within hoop 342. This configuration provides some advantages. For instance, hoop 342 can better follow the vasculature without kinking or prolapsing (i.e., without collapsing upon itself). Thus, certain positioning or repositioning of filter 344 can be accomplished with less difficulty.
  • FIG. 21B illustrates a [0101] protection device 352 in accordance with another embodiment of the present invention. Protection device 352 is similar to protection device 340, and similar items are similarly numbered. However, rather than having simply a hoop-shaped frame 342 to support filter 344, and drive filter 344 into its expanded and deployed position device 352 includes frame 354 which includes a hoop-shaped portion 356, and a pair of tails 358 and 360.
  • [0102] Tails 358 and 360 extend proximally from hoop-shaped portion 356 to an attachment region 362 in the preferred embodiment, tails 358 and 360 are attached to wire 346 at attachment region 362 by soldering, welding, brazing, adhesive, or any other suitable attachment mechanism. In the embodiment shown in FIG. 21B, attachment sleeve 364, formed of a weldable material, is attached at its inner periphery to tails 358 and 360. Sleeve 364 is then attached, using welding or brazing to wire 346.
  • By providing [0103] tails 358 and 360, frame 354 is directly connected to wire 346. However, tails 358 and 360 are provided so that the point of attachment of frame 354 to wire 346 is located several millimeters proximal of hoop-shaped portion 356. This provides some additional structural integrity to frame 354, but still allows frame 354 to substantially float about wire 346 in the region of hoop-shaped frame portion 356.
  • FIG. 21C illustrates a [0104] protection device 366 in accordance with another embodiment of the present invention. Protection device 366 is similar to protection devices 340 and 352 shown in FIGS. 21A and 21B, and similar items are similarly numbered. However, device 366 includes hoop-shaped frame 368. Frame 368 is similar to frame 342 shown in FIG. 21A. However, unlike frame 342, hoop 368 does not allow wire 346 to float freely therein. Instead, hoop 368 is directly attached to wire 346 at attachment point 370. This causes hoop-shaped frame 368 and filter 344 to reside eccentrically about wire 346.
  • FIGS. [0105] 22A-22C illustrate one preferred embodiment for delivering one of devices 340, 352 and 366. For the sake of clarity, only device 352 is illustrated in FIGS. 22A-22C.
  • FIG. 22A illustrates [0106] delivery device 372. In the preferred embodiment, delivery device 372 includes proximal hub 374, shaft 376, and distal retaining section 378. Also, in one preferred embodiment, device 372 also includes marker band 380. In the preferred embodiment, delivery device 372 is similar to a conventional balloon catheter in that proximal hub 374 is a conventional hub, and shaft 376 is a conventional balloon catheter shaft. Further, distal retaining section 378 is preferably a conventional angioplasty balloon having an inflated diameter of approximately 1.5-2.0 millimeters, but having its distal end cutoff such that the distal end 382 of balloon 378 is open.
  • Prior to insertion of [0107] device 372 into the vasculature, hoop-shaped frame 354 is retracted into its low profile deployment position and is withdrawn through end 382, into balloon 378. Then, the distal end of balloon 378 is exposed to heat to heat shrink or heat set the distal end of balloon 378 around the radially retracted device 352. Device 372, including device 352, is then inserted in the vasculature either through a preplaced guide catheter, along with a guide catheter, or simply without a guide catheter utilizing coil tip 348.
  • In any case, once [0108] device 372 is properly placed such that balloon 378 is located distal of the restriction to be treated, distal protection device 352 is then removed from within heat collapsed balloon 378. In one preferred embodiments the physician simply accomplishes longitudinal movement of wire 346 relative to catheter 376. For instance, the physician may simply hold wire 346 longitudinally in place and withdraw catheter 376 proximally relative to wire 346 by pulling on hub 374. This causes balloon 378 to move proximally relative to device 352, and thereby to expose device 352 to the vasculature.
  • FIG. 22B illustrates another preferred embodiment for removing [0109] device 352 from within balloon 378. In the embodiment shown in FIG. 22B, syringe 384, which contains fluid, is inserted into coupling 386 in hub 374. The physician then introduces pressurized fluid into the lumen of catheter 376. The pressurized fluid advances down the lumen of catheter 376 to the distal end where it encounters collapsed balloon 378. The pressure exerted on balloon 378 by the pressurized fluid causes balloon 378 to open radially. Then, the physician withdraws catheter 376 relative to device 352 thereby exposing device 352 to the vasculature.
  • In any case, once [0110] device 352 is no longer restrained by balloon 378, device 352 assumes its shape memory position in the vasculature, as illustrated in FIG. 22C. Thus, device 352 substantially forms a lumen-filling basket or filter which allows blood to pass distally therethrough, but which retains or captures embolic material carried by the blood flow. The physician then simply removes device 372 from the vasculature, leaving device 352 in place during subsequent procedures. In one preferred embodiment, shaft 376 includes a predefined slit or score from a region just proximal of marker band 380 to, or through, hub 374. Thus, as the physician removes device 372, it can be peeled away from device 352. Also, or alternatively, device 372 can be provided with an aperture in shaft 376 near its distal end. The proximal end of wire 346 will thus lie outside of shaft 376. Wire 346 can enter shaft 376 through the aperture and extend through the distal end of shaft 376. This also facilitates easier withdrawal of device 372 over wire 346.
  • FIGS. [0111] 23A-23E illustrate one preferred embodiment for retrieving one of the devices 340, 352 and 366 described in FIGS. 21A-21C. For the sake of clarity, only device 352 is illustrated in FIGS. 23A-23E. FIG. 23A illustrates retrieval device 388. Retrieval device 388 is preferably formed of proximal shaft 390, mesh portion 392, and end cap 394. Items 390, 392 and 394 preferably each have lumens therein to define a passageway for receiving wire 346. Also, wire 346 may optionally be provided with an positive stop 396 (which can be embodied as a radiopaque marker band) Optional stop 396 may also simply be an annular ring attached to wire 346 proximate to filter 344, or may be any other suitable stop.
  • [0112] Proximal shaft 390 is preferably simply a polymer or nitinol tube sized and configured to track over wire 346. End cap 394 is also preferably formed to track over wire 346, but also contains radiopaque material to serve as a distal marker band for retrieval device 388 mesh 392 is preferably a braid or mesh formed of wire or polymer material having sufficient flexibility that it can be deflected as described below.
  • [0113] Mesh 392 preferably has a proximal end coupled to proximal shaft 390, by adhesive, welding, or other suitable attachment mechanisms. Mesh 392 also preferably includes a distal end connected to end cap 394, also by a suitable connection mechanism.
  • In order to retrieve [0114] filter 344, which likely contains embolic materials, device 380 is inserted in the low profile position shown in FIG. 23A, over wire 346, to apposition proximate filter 344. Then, device 388 is advanced toward filter 344, until end cap 394 abuts positive stop 396; or the hoop-shaped frame 354. Continued advancement of proximal shaft 390 relative to wire 346 causes compression of mesh 392. This results in a radial expansion of an intermediate portion of mesh 392 (between the proximal and distal ends of mesh 392). The radial expansion of mesh portion 392 is illustrated in FIG. 23B.
  • By continuing to advance [0115] proximal shaft 390 relative to wire 346, the intermediate portion of mesh 392 is configured to bend over on itself such that it is axially displaced toward filter 344, in the direction generally indicated by arrows 398 in FIG. 23C. In the preferred embodiment, mesh 392 is sized and configured such that, with continued advancement of proximal shaft 390 relative to wire 346, this action continues as shown in FIGS. 23D and 23E until the intermediate portion of mesh 392 encompasses at least the mouth of filter 344. Also, in the preferred embodiment, the intermediate portion of mesh 392, when driven as described above, engages and contracts the mouth of filter 344 to a lower profile position, such as that shown in FIG. 23E. In yet another preferred embodiment, mesh 392 is sized and configured to substantially engulf the entire filter 344.
  • Once at least the mouth of [0116] filter 344 is encompassed by mesh 392, device 388, along with device 352, are simply withdrawn from the vasculature. In one preferred embodiment in which a guide catheter is used devices 388 and 352 are simply withdrawn either into the guide catheter and the guide catheter is removed with those devices simultaneously or devices 388 and 352 are removed from the guide catheter prior to removal of the guide catheter. In another preferred embodiment, in which no guide catheter is used devices 388 and 352 are simply removed from the vasculature simultaneously.
  • It will also be appreciated, of course, that rather than providing [0117] device 388 with a single proximal tube 390 and end cap 394, a second actuation tube or wire can also be provided which is attached to end cap 394, and which extends back through the lumen in proximal tube 390 and is longitudinally movable relative to proximal shaft 390. In that way, the actuation wire or elongate member can be used to pull cap 394 closer to the distal portion of proximal shaft 390 in order to accomplish the action illustrated in FIGS. 23A-23E. This feature is also illustrated in FIGS. 18A-21D which illustrate the mesh portion folded proximally rather than distally.
  • FIGS. [0118] 24A-24C illustrate another preferred embodiment in accordance with the present invention, for retrieving any of the distal protection devices 340, 352 or 366 shown in FIGS. 21A-21C. For the sake of clarity, only device 352 is illustrated in FIGS. 24A-24C.
  • FIG. 24A illustrates [0119] retrieval device 400. Retrieval device 400 preferably includes retrieval sheath 402, proximal locking device 404, dilator sheath 405 and nose cone 406. In the preferred embodiment, retrieval sheath 402 is preferably formed of polyether block amide (PEBAX) material having an outer diameter of approximately six French (i.e., approximately 2 mm) and having a shore D hardness of approximately 40. Also, retrieval sheath 402 preferably has a wall thickness of approximately 0.004 inches. Dilator sheath 405, and nose cone 406, are preferably formed of low density polyethylene, or high density polyethylene. Sheath 405 preferably has an: outer diameter which is approximately equal to the inner diameter of sheath 402. In addition, the inner diameter of sheath 405 and in cone 406 is preferably just large enough to fit over, and track over, wire 346. Nose cone 406 preferably has a proximal portion which is either attached to, or formed integrally with, sheath 405. The outer diameter of the proximal portion of nose cone 406 is also approximately the same as the outer diameter of sheath 405. However, nose cone 406 also preferably has a distal portion which tapers, or reduces along preferably a smooth curve, to an outer diameter which terminates at the inner diameter of nose cone 406.
  • [0120] Proximal locking device 404 is preferably any suitable, and commercially available, locking device which can be configured to lock dilator sheath 405 to guidewire 346.
  • In order to retrieve .[0121] device 352 from the vasculature, device 400 is preferably advanced over guidewire 346 to a position shown in FIG. 24B, in which the distal portion of nose cone 406 is closely proximate, or adjacent to, either optional stop 396 or the mouth of filter 344. Then, proximal locking devil 404 is actuated to lock dilator sheath 405 to wire 346 so that wire 346 and dilator sheath 405 (as well as nose cone 406) can be moved as a unitary piece.
  • Next, wire [0122] 346 (and hence dilator sheath 405 and nose cone 406) are withdrawn longitudinally relative to retrieval sheath 402. This causes the mouth of filter 344 to enter within the distal opening in retrieval sheath 402. This results in device 352 being positioned relative to sheath 402 as shown in FIG. 24C. Of course, wire 346 dilator sheath 405 and nose cone 406 can be withdrawn further into sheath 402 such that the entire filter 344, and wire tip 348, are disposed within the lumen of sheath 402.
  • In any case, once at least the mouth of [0123] filter 344 is within sheath 402, device 352 is configured to be removed from the vasculature. This can be accomplished by either removing dilator sheath 405, nose cone 406 and device 352 as a unitary piece, leaving sheath 402 in place for later removal, or by removing sheath 402 with the remainder of the system, either through a guide catheter or simply through the vasculature, simultaneously. Also, where a guide catheter is used, device 352 and device 400 can be removed through the guide catheter leaving the guide catheter in place, or the guide catheter can be removed simultaneously with the other devices 352 and 400.
  • It should be noted that all of the devices according to the present invention can optionally be coated with an antithrombotic material, such as heparin (commercially available under the trade name Duraflow from Baxter), to inhibit clotting. [0124]
  • Thus, in accordance with one preferred embodiment of the present invention, the super elastic properties of nitinol are used to form a frame at least in the area of the: mouth of the distal protection filter. Thus, the distal protection device can be deployed, retrieved, and redeployed any number of times without incurring plastic deformation. In addition in other preferred embodiments in accordance with the present invention, various deployment and retrieval techniques and systems are .provided which address various problems associated with such systems. [0125]
  • Although the present invention has, been described with reference to preferred embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention. [0126]

Claims (30)

What is claimed is:
1. An emboli capturing system for capturing emboli in a body lumen, comprising:
a first elongate member having a proximal end and a distal end;
an expandable emboli capturing device mounted proximate the distal end of the first elongate member, the emboli capturing device being movable between a radially expanded position and a radially retracted position, the expandable emboli capturing device forming a basket with a proximally opening mouth when in the radially expanded position;
a second elongate member having a proximal end and a distal end and a lumen extending between the proximal and distal ends the lumen being sized to slidably receive a portion of the first elongate member therein; and
an expandable delivery device mounted to the distal end of the second elongate member and being movable from a radially retracted position to a radially expanded position, the delivery device having a receiving end configured to receive the emboli capturing device the delivery device retaining at least the mouth of the emboli capturing device in the radially retracted position when the delivery device is in the radially retracted position, the emboli capturing device being longitudinally movable out from within the delivery device when the delivery device is in the radially expanded position.
2. The emboli capturing system of claim 1 and further comprising:
a retrieval device, configured to be longitudinally movable relative to the emboli capturing device in the body lumen and having a receiving end configured to receive at least the mouth of the emboli capturing device when the emboli capturing device is in the radially expanded position.
3. The emboli capturing system of claim 2 wherein the retrieval device comprises the expandable delivery device in the radially expanded position.
4. The emboli capturing system of claim 2 wherein the receiving end of the retrieval device is contractible from a radially expanded position to a radially contracted position to at least partially collapse the emboli capturing device therein.
5. The emboli capturing system of claim 4 wherein the retrieval device comprises:
a third elongate member having proximal and distal ends and a lumen extending therebetween, the lumen being sized to slidably receive at least a portion of the first elongate member therein, the lumen at the distal end of the third elongate member forming the receiving end and being sized to receive a most radially expanded portion of the emboli capturing device; and
a fourth elongate member movable within the lumen of the third elongate member, the fourth elongate member having an intermediate region sized to substantially fill the receiving end and a distal tip having an outer diameter less than an outer diameter of the intermediate region.
6. The emboli capturing system of claim 5 wherein the distal tip of the fourth elongate member is configured with an aperture therein sized to track over the first elongate member.
7. The emboli capturing system of claim 6 wherein the fourth elongate member is formed in a substantially conical shape between the distal tip thereof and the intermediate region thereof.
8. The emboli capturing system of claim 2 wherein the retrieval device includes:
a third elongate member having proximal and distal ends and a lumen extending therebetween, the lumen being sized to slidably receive at least a portion of the first elongate member; and
a mesh sleeve having a first end coupled to the third elongate member, a second end distal of the first end and an intermediate portion between the first and second ends, the mesh sleeve being configured such that relative longitudinal movement of one of the first and second ends thereof relative to another of the first and second ends thereof drives movement of the mesh portion from a radially retracted position, to a radially expanded position in which the intermediate portion expands radially outward relative to the first and second ends, and to a collapsed position in which the mesh sleeve bends such that the intermediate portion is displaced in a direction toward one of the first and second ends of the mesh sleeve.
9. The emboli capturing system of claim 8 wherein the retrieval device is configured such that sufficient longitudinal movement of the emboli capturing device toward the mesh sleeve causes the emboli capturing device to drive the second end of the mesh sleeve toward the first end of the mesh sleeve.
10. The emboli capturing system of claim 9 wherein the mesh sleeve is sized to encompass at least the mouth of the emboli capturing device as the mesh sleeve moves from the radially expanded position to the collapsed position.
11. The emboli capturing system of claim 2 wherein the retrieval device includes:
third elongate member having proximal and distal ends and a lumen extending therebetween, the lumen being sized to slidably receive at least a portion of the first elongate member;
a fourth elongate member longitudinally movable relative to the third elongate member; and
a mesh sleeve having a first end coupled to the third elongate member and a second end coupled to the fourth elongate member and an intermediate portion between the first and second ends, the mesh sleeve being configured such that relative longitudinal movement of one of the third and fourth elongate members relative to another of the third and fourth elongate members drives movement of the mesh portion from a radially retracted position, to a radially expanded position in which the intermediate portion expands radially outward relative to the first and second ends, and to a collapsed position in which the mesh sleeve bends such that the intermediate portion is displaced in a direction toward one of the first and second ends of the mesh sleeve.
12. The emboli capturing system of claim 1 wherein the receiving end of the delivery device is defined by a portion of a dilatation balloon.
13. The emboli capturing system of claim 1 wherein the receiving end of the delivery device is thermally shrunk over at least the mouth of the emboli capturing device to retain the emboli capturing device in the radially contracted position during delivery.
14. The emboli capturing system of claim 1 wherein the receiving end of the delivery device is movable from the radially retracted position to the radially expanded position by delivery of pressurized fluid through the lumen in the second elongate member.
15. The emboli capturing system of claim 1 wherein the emboli capturing device is a self-expanding device biased in the radially expanded position.
16. The emboli capturing system of claim 15 wherein the emboli capturing device includes:
a frame formed of a shape memory alloy; and
a filter portion supported by the frame, the filter portion being configured to permit blood flow therethrough and to capture emboli carried by blood, flow therethrough.
17. The emboli capturing system of claim 16 wherein the filter portion has a first end connected to the first elongate member and a second end connected to the frame and wherein the frame comprises:
a loop disposed about the first elongate member to define the mouth of the emboli capturing device.
18. The emboli capturing system of claim 17 wherein the loop is directly connected to the first elongate member.
19. The emboli capturing system of claim 17 wherein the shape memory alloy comprises an alloy having superelastic properties.
20. The emboli capturing system of claim 19 wherein the shape memory alloy includes nitinol.
21. The emboli capturing system of claim 20 wherein the emboli capturing device is substantially conical in shape.
22. The emboli capturing system of claim 21 wherein the filter portion comprises a polyurethane member having a plurality of holes therein.
23. The emboli capturing system of claim 1 wherein the first elongate member comprises a guidewire.
24. A method of capturing emboli carried by flow of fluid through a body lumen, the method comprising:
providing a first elongate member having a proximal end and a distal end;
providing an expandable emboli capturing device mounted proximate the distal end of the first elongate member, the emboli capturing device being movable between a radially expanded position and a radially retracted position, the expandable emboli capturing device defining a proximally opening mouth when in the radially expanded position;
providing a second elongate member having a proximal end and a distal end and a lumen extending between the proximal and distal ends, the lumen being sized to slidably receive a portion of the first elongate member therein;
providing an expandable delivery device mounted to the distal end of the second elongate member and being movable from A radially retracted position to a radially expanded position, the delivery device having a receiving end configured to receive the emboli capturing device, the delivery device retaining at least the mouth of the emboli capturing device in the radially retracted position when the delivery device is in the radially retracted position;
inserting the expandable delivery device into the lumen with the mouth of the emboli capturing device retained in the radially retracted position within the delivery device;
expandable delivery device into the radially expanded position; and
longitudinally moving the delivery device relative to the emboli capturing device to remove the emboli capturing device from within the delivery device.
25. The method of claim 24 and further comprising:
providing a retrieval device, configured to be longitudinally movable relative to the emboli capturing device in the body lumen and having a receiving end configured to receive at least the mouth of the emboli capturing device when the emboli capturing device is in the radially expanded position; and
longitudinally moving the delivery device relative to the emboli capturing device such that at least the mouth of the emboli capturing device is in the receiving end of the retrieval device.
26. The method of claim 25 wherein the receiving end of the retrieval device is contractible from a radially expanded position to a radially contracted position, and further comprising:
contracting the receiving end of the retrieval device to at least partially collapse the emboli capturing device therein.
27. The method of claim 26 wherein providing a retrieval device comprises:
providing a third elongate member having proximal and distal ends and a lumens extending therebetween, the lumen being sized to slidably receive at least a portion of the first elongate member therein, the lumen at the distal end of the third elongate member forming the receiving end and being sized to receive a most radially expanded portion of the emboli capturing device;
providing a fourth elongate member movable within the lumen of the third elongate member, the fourth elongate member having an intermediate region sized to substantially fill the receiving end and a distal tip having an outer diameter less than an outer diameter of the intermediate region;
advancing the third and fourth elongate members over the first elongate member, with the intermediate region of the fourth elongate member positioned within the third elongate member to fill the receiving end thereof, to a point proximate the emboli capturing device;
withdrawing the distal tip of the fourth elongate member within the lumen of the third elongate member; and
positioning at least the mouth of the emboli capturing device within the receiving end of the retrieval device.
28. The method of claim 27 and further comprising:
withdrawing the first, third, and fourth elongate members from the body lumen.
29. The method of claim 25 wherein providing the retrieval device includes:
providing a third elongate member having proximal and distal ends and a lumen extending therebetween, the lumen being sized to slidably receive at least a portion of the first elongate member;
providing a mesh having a first end coupled to the third elongate member, a second end distal of the first end and an intermediate portion between the first and second ends, the mesh sleeve being configured such that relative longitudinal movement of one of the first and second ends thereof relative to another of the first and second ends thereof drives movement of the mesh portion from a radially retracted position, to a radially expanded position in which the intermediate portion expands radially outward relative to the first and second ends, and to a collapsed position in which the mesh sleeve bends such that the intermediate portion is displaced in a direction toward one of the first and second ends of the mesh sleeve;
advancing the third elongate member into the body lumen over the first elongate member to a point proximate the mouth of the emboli capturing device; and
accomplishing relative longitudinal movement of the emboli capturing device and the mesh sleeve toward one another, driving the second end of the mesh sleeve toward the first end of the mesh sleeve such that the mesh sleeve encompasses at least the mouth of the emboli capturing device as the mesh sleeve moves from the radially expanded position to the collapsed position.
30. The method of claim 24 wherein expanding comprises:
delivering pressurized fluid through the lumen in the second elongate member.
US10/346,373 1997-03-06 2003-01-17 Distal protection device and method Abandoned US20030130686A1 (en)

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US08/810,825 US5814064A (en) 1997-03-06 1997-03-06 Distal protection device
US08/813,794 US5827324A (en) 1997-03-06 1997-03-06 Distal protection device
US08/943,358 US6001118A (en) 1997-03-06 1997-10-03 Distal protection device and method
US09/409,497 US6245089B1 (en) 1997-03-06 1999-09-30 Distal protection device and method
US09/735,332 US20010044632A1 (en) 1997-03-06 2000-12-12 Distal protection device and method
US10/160,450 US6663652B2 (en) 1997-03-06 2002-05-30 Distal protection device and method
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US09/082,096 Expired - Lifetime US6053932A (en) 1997-03-06 1998-05-20 Distal protection device
US09/409,497 Expired - Lifetime US6245089B1 (en) 1997-03-06 1999-09-30 Distal protection device and method
US09/735,332 Abandoned US20010044632A1 (en) 1997-03-06 2000-12-12 Distal protection device and method
US10/160,450 Expired - Lifetime US6663652B2 (en) 1997-03-06 2002-05-30 Distal protection device and method
US10/346,373 Abandoned US20030130686A1 (en) 1997-03-06 2003-01-17 Distal protection device and method
US10/346,372 Expired - Lifetime US6872216B2 (en) 1997-03-06 2003-01-17 Distal protection device and method
US10/346,519 Abandoned US20030130687A1 (en) 1997-03-06 2003-01-17 Distal protection device and method
US10/346,975 Abandoned US20030130688A1 (en) 1997-03-06 2003-01-17 Distal protection device and method
US10/650,304 Abandoned US20040106944A1 (en) 1997-03-06 2003-08-28 Distal protection device and method
US10/650,303 Abandoned US20050101986A1 (en) 1997-03-06 2003-08-28 Distal protection device and method
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US09/082,096 Expired - Lifetime US6053932A (en) 1997-03-06 1998-05-20 Distal protection device
US09/409,497 Expired - Lifetime US6245089B1 (en) 1997-03-06 1999-09-30 Distal protection device and method
US09/735,332 Abandoned US20010044632A1 (en) 1997-03-06 2000-12-12 Distal protection device and method
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Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187570A1 (en) * 2004-02-19 2005-08-25 Applied Medical Resources Corporation Embolectomy capture sheath
US20060223386A1 (en) * 2005-03-15 2006-10-05 Dharmendra Pal Embolic protection device
US20060287671A1 (en) * 2002-09-04 2006-12-21 Boston Scientific Scimed, Inc. Sheath tip
US20070162070A1 (en) * 1997-11-07 2007-07-12 Salviac Limited Embolic protection device
US7678129B1 (en) 2004-03-19 2010-03-16 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7780697B2 (en) 1997-11-07 2010-08-24 Salviac Limited Embolic protection system
US7780694B2 (en) 1999-12-23 2010-08-24 Advanced Cardiovascular Systems, Inc. Intravascular device and system
US7799051B2 (en) 1999-05-07 2010-09-21 Salviac Limited Support frame for an embolic protection device
US7815660B2 (en) 2002-09-30 2010-10-19 Advanced Cardivascular Systems, Inc. Guide wire with embolic filtering attachment
US7842064B2 (en) 2001-08-31 2010-11-30 Advanced Cardiovascular Systems, Inc. Hinged short cage for an embolic protection device
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US7867273B2 (en) 2007-06-27 2011-01-11 Abbott Laboratories Endoprostheses for peripheral arteries and other body vessels
US7892251B1 (en) 2003-11-12 2011-02-22 Advanced Cardiovascular Systems, Inc. Component for delivering and locking a medical device to a guide wire
US7901427B2 (en) 1997-11-07 2011-03-08 Salviac Limited Filter element with retractable guidewire tip
US7918820B2 (en) 1999-12-30 2011-04-05 Advanced Cardiovascular Systems, Inc. Device for, and method of, blocking emboli in vessels such as blood arteries
US7927349B2 (en) 2001-12-21 2011-04-19 Salviac Limited Support frame for an embolic protection device
US7931666B2 (en) 2000-12-19 2011-04-26 Advanced Cardiovascular Systems, Inc. Sheathless embolic protection system
US7959647B2 (en) 2001-08-30 2011-06-14 Abbott Cardiovascular Systems Inc. Self furling umbrella frame for carotid filter
US7959646B2 (en) 2001-06-29 2011-06-14 Abbott Cardiovascular Systems Inc. Filter device for embolic protection systems
US7972356B2 (en) 2001-12-21 2011-07-05 Abbott Cardiovascular Systems, Inc. Flexible and conformable embolic filtering devices
US7976560B2 (en) 2002-09-30 2011-07-12 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US8002790B2 (en) 1999-05-07 2011-08-23 Salviac Limited Support frame for an embolic protection device
US8016854B2 (en) 2001-06-29 2011-09-13 Abbott Cardiovascular Systems Inc. Variable thickness embolic filtering devices and methods of manufacturing the same
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US8137377B2 (en) 1999-12-23 2012-03-20 Abbott Laboratories Embolic basket
US8142442B2 (en) 1999-12-23 2012-03-27 Abbott Laboratories Snare
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US8177791B2 (en) 2000-07-13 2012-05-15 Abbott Cardiovascular Systems Inc. Embolic protection guide wire
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US8262689B2 (en) 2001-09-28 2012-09-11 Advanced Cardiovascular Systems, Inc. Embolic filtering devices
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US8591540B2 (en) 2003-02-27 2013-11-26 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US8845583B2 (en) 1999-12-30 2014-09-30 Abbott Cardiovascular Systems Inc. Embolic protection devices
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US9259305B2 (en) 2005-03-31 2016-02-16 Abbott Cardiovascular Systems Inc. Guide wire locking mechanism for rapid exchange and other catheter systems
US9820845B2 (en) 2003-03-28 2017-11-21 Covidien Lp Holding zone for intravascular medical device
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US9907639B2 (en) 2006-09-19 2018-03-06 Cook Medical Technologies Llc Apparatus and methods for in situ embolic protection

Families Citing this family (851)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001591A1 (en) * 1994-07-08 1996-01-25 Microvena Corporation Method of forming medical devices; intravascular occlusion devices
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US6994689B1 (en) 1995-06-05 2006-02-07 Medtronic Vascular, Inc. Occlusion of a vessel
US6168604B1 (en) * 1995-10-06 2001-01-02 Metamorphic Surgical Devices, Llc Guide wire device for removing solid objects from body canals
US5989281A (en) * 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US6800080B1 (en) 1996-05-03 2004-10-05 Scimed Life Systems, Inc. Medical retrieval device
US6096053A (en) * 1996-05-03 2000-08-01 Scimed Life Systems, Inc. Medical retrieval basket
US6048331A (en) * 1996-05-14 2000-04-11 Embol-X, Inc. Cardioplegia occluder
US6544276B1 (en) * 1996-05-20 2003-04-08 Medtronic Ave. Inc. Exchange method for emboli containment
US20050245894A1 (en) * 1996-05-20 2005-11-03 Medtronic Vascular, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6270477B1 (en) * 1996-05-20 2001-08-07 Percusurge, Inc. Catheter for emboli containment
US6022336A (en) 1996-05-20 2000-02-08 Percusurge, Inc. Catheter system for emboli containment
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US6391044B1 (en) 1997-02-03 2002-05-21 Angioguard, Inc. Vascular filter system
EP1226796B1 (en) 1997-02-03 2005-06-01 Angioguard, Inc. Vascular filter
US6974469B2 (en) * 1997-03-06 2005-12-13 Scimed Life Systems, Inc. Distal protection device and method
EP0934092A4 (en) * 1997-03-06 2008-03-26 Boston Scient Scimed Inc Distal protection device and method
US6849068B1 (en) 1997-03-06 2005-02-01 Medtronic Ave, Inc. Aspiration catheter
US6251086B1 (en) * 1999-07-27 2001-06-26 Scimed Life Systems, Inc. Guide wire with hydrophilically coated tip
US5814064A (en) * 1997-03-06 1998-09-29 Scimed Life Systems, Inc. Distal protection device
US6152946A (en) * 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
CA2322876A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Intravascular aspiration system
WO1998047447A1 (en) * 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5846260A (en) * 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US6676682B1 (en) 1997-05-08 2004-01-13 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5911734A (en) * 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6743246B1 (en) 1997-05-08 2004-06-01 Edwards Lifesciences Corporation Devices and methods for protecting a patient from embolic material during surgery
US6258120B1 (en) * 1997-12-23 2001-07-10 Embol-X, Inc. Implantable cerebral protection device and methods of use
US5954745A (en) * 1997-05-16 1999-09-21 Gertler; Jonathan Catheter-filter set having a compliant seal
US6059814A (en) * 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US6761727B1 (en) * 1997-06-02 2004-07-13 Medtronic Ave, Inc. Filter assembly
US5947995A (en) * 1997-06-06 1999-09-07 Samuels; Shaun Lawrence Wilkie Method and apparatus for removing blood clots and other objects
US6245088B1 (en) 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
US6395014B1 (en) * 1997-09-26 2002-05-28 John A. Macoviak Cerebral embolic protection assembly and associated methods
US6361545B1 (en) * 1997-09-26 2002-03-26 Cardeon Corporation Perfusion filter catheter
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US6461370B1 (en) * 1998-11-03 2002-10-08 C. R. Bard, Inc. Temporary vascular filter guide wire
US20100030256A1 (en) 1997-11-12 2010-02-04 Genesis Technologies Llc Medical Devices and Methods
US20040260333A1 (en) * 1997-11-12 2004-12-23 Dubrul William R. Medical device and method
US9498604B2 (en) * 1997-11-12 2016-11-22 Genesis Technologies Llc Medical device and method
US20040199202A1 (en) * 1997-11-12 2004-10-07 Genesis Technologies Llc Biological passageway occlusion removal
DE69839888D1 (en) * 1997-11-12 2008-09-25 Genesis Technologies Llc DEVICE FOR REMOVING OCCLUSIONS IN BIOLOGICAL PASSES
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
WO2001072205A2 (en) * 1998-01-26 2001-10-04 Advanced Cardiovascular Systems, Inc. Method and apparatus for capturing objects beyond an operative site in medical procedures
EP1054634A4 (en) 1998-02-10 2006-03-29 Artemis Medical Inc Entrapping apparatus and method for use
US6602265B2 (en) 1998-02-10 2003-08-05 Artemis Medical, Inc. Tissue separation medical device and method
ATE454098T1 (en) * 1998-02-10 2010-01-15 Artemis Medical Inc OCCLUSION, ANCHORING, CHIPING OR POWER CONTROL DEVICE
US6338709B1 (en) 1998-02-19 2002-01-15 Medtronic Percusurge, Inc. Intravascular radiation therapy device and method of use
ATE308276T1 (en) 1998-03-31 2005-11-15 Transvascular Inc TISSUE-PENETRATING CATHETER WITH TRANSDUCER FOR IMAGING AND ASSOCIATED METHODS OF APPLICATION
CN1295451A (en) 1998-04-02 2001-05-16 萨尔维亚克有限公司 Delivery catheter
US6383195B1 (en) * 1998-04-13 2002-05-07 Endoline, Inc. Laparoscopic specimen removal apparatus
US20100036481A1 (en) * 1998-04-27 2010-02-11 Artemis Medical, Inc. Cardiovascular Devices and Methods
US6450989B2 (en) * 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US6511492B1 (en) * 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
JP4741728B2 (en) 1998-06-04 2011-08-10 ニューヨーク・ユニバーシティ Intravascular thin film device and stroke treatment
IL124958A0 (en) * 1998-06-16 1999-01-26 Yodfat Ofer Implantable blood filtering device
US6231588B1 (en) 1998-08-04 2001-05-15 Percusurge, Inc. Low profile catheter for angioplasty and occlusion
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6440120B1 (en) * 1998-09-02 2002-08-27 Embol-X, Inc. Bendable shape-retaining cannula
US6093173A (en) * 1998-09-09 2000-07-25 Embol-X, Inc. Introducer/dilator with balloon protection and methods of use
US6328755B1 (en) 1998-09-24 2001-12-11 Scimed Life Systems, Inc. Filter delivery device
US7314477B1 (en) 1998-09-25 2008-01-01 C.R. Bard Inc. Removable embolus blood clot filter and filter delivery unit
US6652554B1 (en) 1999-01-04 2003-11-25 Mark H. Wholey Instrument for thromboembolic protection
US6254610B1 (en) * 1999-05-24 2001-07-03 Impulse Dynamics N.V. Device and method for dragging and positioning a member within a duct in a body
WO2000042956A1 (en) * 1999-01-21 2000-07-27 Impulse Dynamics (Israel) Ltd. A device and method for dragging and positioning a member within a duct in a body
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US6991641B2 (en) * 1999-02-12 2006-01-31 Cordis Corporation Low profile vascular filter system
US20020138094A1 (en) * 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
US6500147B2 (en) * 1999-02-22 2002-12-31 Medtronic Percusurge, Inc. Flexible catheter
US6171327B1 (en) 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6355051B1 (en) 1999-03-04 2002-03-12 Bioguide Consulting, Inc. Guidewire filter device
US6146396A (en) * 1999-03-05 2000-11-14 Board Of Regents, The University Of Texas System Declotting method and apparatus
US20020169474A1 (en) * 1999-03-08 2002-11-14 Microvena Corporation Minimally invasive medical device deployment and retrieval system
US20040167613A1 (en) * 1999-03-11 2004-08-26 Ofer Yodfat Implantable stroke prevention device
US6245012B1 (en) * 1999-03-19 2001-06-12 Nmt Medical, Inc. Free standing filter
US6743247B1 (en) 1999-04-01 2004-06-01 Scion Cardio-Vascular, Inc. Locking frame, filter and deployment system
US6277138B1 (en) 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
US7150756B2 (en) * 1999-04-01 2006-12-19 Scion Cardio-Vascular, Inc Radiopaque locking frame, filter and flexible end
US6537296B2 (en) 1999-04-01 2003-03-25 Scion Cardio-Vascular, Inc. Locking frame, filter and deployment system
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
WO2000067666A1 (en) * 1999-05-07 2000-11-16 Salviac Limited Improved filter element for embolic protection device
EP1176923A1 (en) 1999-05-07 2002-02-06 Salviac Limited An embolic protection device
US20020058911A1 (en) * 1999-05-07 2002-05-16 Paul Gilson Support frame for an embolic protection device
US7014647B2 (en) 1999-05-07 2006-03-21 Salviac Limited Support frame for an embolic protection device
WO2000067641A1 (en) * 1999-05-11 2000-11-16 Williamson Warren P Iv Surgical clamp devices and methods especially useful in cardiac surgery
US6350271B1 (en) 1999-05-17 2002-02-26 Micrus Corporation Clot retrieval device
US6458139B1 (en) 1999-06-21 2002-10-01 Endovascular Technologies, Inc. Filter/emboli extractor for use in variable sized blood vessels
US7416554B2 (en) 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US20040122456A1 (en) * 2002-12-11 2004-06-24 Saadat Vahid C. Methods and apparatus for gastric reduction
US7618426B2 (en) 2002-12-11 2009-11-17 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US20030150821A1 (en) * 1999-07-16 2003-08-14 Bates Mark C. Emboli filtration system and methods of use
US6468291B2 (en) 1999-07-16 2002-10-22 Baff Llc Emboli filtration system having integral strut arrangement and methods of use
US7547302B2 (en) * 1999-07-19 2009-06-16 I-Flow Corporation Anti-microbial catheter
US7004923B2 (en) * 1999-07-19 2006-02-28 I-Flow Corporation Catheter for uniform delivery of medication
US6350253B1 (en) * 1999-07-19 2002-02-26 I-Flow Corporation Catheter for uniform delivery of medication
EP1207933B1 (en) * 1999-07-30 2011-05-11 Incept Llc Vascular filter having articulation region
US7229463B2 (en) * 1999-07-30 2007-06-12 Angioguard, Inc. Vascular filter system for cardiopulmonary bypass
US6616679B1 (en) 1999-07-30 2003-09-09 Incept, Llc Rapid exchange vascular device for emboli and thrombus removal and methods of use
US7229462B2 (en) * 1999-07-30 2007-06-12 Angioguard, Inc. Vascular filter system for carotid endarterectomy
US6371970B1 (en) 1999-07-30 2002-04-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6179861B1 (en) 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
US6544279B1 (en) 2000-08-09 2003-04-08 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US7306618B2 (en) 1999-07-30 2007-12-11 Incept Llc Vascular device for emboli and thrombi removal and methods of use
CA2378715C (en) * 1999-07-30 2011-09-06 Incept Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US6530939B1 (en) * 1999-07-30 2003-03-11 Incept, Llc Vascular device having articulation region and methods of use
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US20020022858A1 (en) * 1999-07-30 2002-02-21 Demond Jackson F. Vascular device for emboli removal having suspension strut and methods of use
US6620182B1 (en) 1999-07-30 2003-09-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6214026B1 (en) 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
US6589263B1 (en) 1999-07-30 2003-07-08 Incept Llc Vascular device having one or more articulation regions and methods of use
US7320697B2 (en) * 1999-07-30 2008-01-22 Boston Scientific Scimed, Inc. One piece loop and coil
US6346116B1 (en) 1999-08-03 2002-02-12 Medtronic Ave, Inc. Distal protection device
US6142987A (en) * 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6235044B1 (en) * 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
FR2797390B1 (en) * 1999-08-10 2001-12-28 Braun Celsa Sa DEVICE FOR TREATING A BODY DUCT THAT HAS AT LEAST ONE PARTIAL OBSTRUCTION
ATE410975T1 (en) * 1999-08-27 2008-10-15 Ev3 Inc SLIDING VASCULAR FILTER
US6146404A (en) * 1999-09-03 2000-11-14 Scimed Life Systems, Inc. Removable thrombus filter
DE29916162U1 (en) * 1999-09-14 2000-01-13 Cormedics Gmbh Vascular filter system
US6368328B1 (en) * 1999-09-16 2002-04-09 Scimed Life Systems, Inc. Laser-resistant medical retrieval device
US6159197A (en) * 1999-09-17 2000-12-12 Richard R. Heuser Method and apparatus for treating body tissues and bodily fluid vessels
US6325815B1 (en) * 1999-09-21 2001-12-04 Microvena Corporation Temporary vascular filter
US6939361B1 (en) 1999-09-22 2005-09-06 Nmt Medical, Inc. Guidewire for a free standing intervascular device having an integral stop mechanism
US6364895B1 (en) * 1999-10-07 2002-04-02 Prodesco, Inc. Intraluminal filter
US6375670B1 (en) * 1999-10-07 2002-04-23 Prodesco, Inc. Intraluminal filter
US6340364B2 (en) * 1999-10-22 2002-01-22 Nozomu Kanesaka Vascular filtering device
US8414543B2 (en) 1999-10-22 2013-04-09 Rex Medical, L.P. Rotational thrombectomy wire with blocking device
US6217589B1 (en) * 1999-10-27 2001-04-17 Scimed Life Systems, Inc. Retrieval device made of precursor alloy cable and method of manufacturing
US6425909B1 (en) * 1999-11-04 2002-07-30 Concentric Medical, Inc. Methods and devices for filtering fluid flow through a body structure
US6994092B2 (en) * 1999-11-08 2006-02-07 Ev3 Sunnyvale, Inc. Device for containing embolic material in the LAA having a plurality of tissue retention structures
US6371971B1 (en) * 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
WO2001035858A1 (en) 1999-11-18 2001-05-25 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including an emboli-capturing catheter
US6623450B1 (en) 1999-12-17 2003-09-23 Advanced Cardiovascular Systems, Inc. System for blocking the passage of emboli through a body vessel
US6443971B1 (en) * 1999-12-21 2002-09-03 Advanced Cardiovascular Systems, Inc. System for, and method of, blocking the passage of emboli through a vessel
WO2001045572A1 (en) * 1999-12-22 2001-06-28 Boston Scientific Limited Endoluminal occlusion-irrigation catheter and methods of use
GB9930654D0 (en) * 1999-12-23 2000-02-16 Halpin Richard M B Device for controlling extra-vascular haemorrhage
AU2736901A (en) * 1999-12-23 2001-07-03 Percusurge, Inc. Strut design for an occlusion device
AU2737001A (en) * 1999-12-23 2001-07-03 Percusurge, Inc. Vascular filters with radiopaque markings
US6290710B1 (en) 1999-12-29 2001-09-18 Advanced Cardiovascular Systems, Inc. Embolic protection device
US6702834B1 (en) 1999-12-30 2004-03-09 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US6383206B1 (en) 1999-12-30 2002-05-07 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including filtering elements
US6540722B1 (en) 1999-12-30 2003-04-01 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US6645220B1 (en) 1999-12-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including and embolic-capturing filter
US6511503B1 (en) 1999-12-30 2003-01-28 Advanced Cardiovascular Systems, Inc. Catheter apparatus for treating occluded vessels and filtering embolic debris and method of use
US7749245B2 (en) * 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
MXPA02007428A (en) * 2000-02-01 2003-10-14 Harold D Kletschka Angioplasty device and method of making same.
US7322957B2 (en) * 2000-02-01 2008-01-29 Harold D. Kletschka Angioplasty device and method of making same
US6443926B1 (en) * 2000-02-01 2002-09-03 Harold D. Kletschka Embolic protection device having expandable trap
US6540767B1 (en) * 2000-02-08 2003-04-01 Scimed Life Systems, Inc. Recoilable thrombosis filtering device and method
US6540768B1 (en) 2000-02-09 2003-04-01 Cordis Corporation Vascular filter system
US6391037B1 (en) 2000-03-02 2002-05-21 Prodesco, Inc. Bag for use in the intravascular treatment of saccular aneurysms
US6346117B1 (en) 2000-03-02 2002-02-12 Prodesco, Inc. Bag for use in the intravascular treatment of saccular aneurysms
ES2282246T3 (en) * 2000-03-10 2007-10-16 Anthony T. Don Michael VASCULAR EMBOLIA PREVENTION DEVICE USING FILTERS.
US7713227B2 (en) * 2000-03-20 2010-05-11 Michael Wholey Method and apparatus for medical device for aspiration of thromboemobolic debris
US6485500B1 (en) 2000-03-21 2002-11-26 Advanced Cardiovascular Systems, Inc. Emboli protection system
US6514273B1 (en) 2000-03-22 2003-02-04 Endovascular Technologies, Inc. Device for removal of thrombus through physiological adhesion
US6592616B1 (en) 2000-04-28 2003-07-15 Advanced Cardiovascular Systems, Inc. System and device for minimizing embolic risk during an interventional procedure
JP4530476B2 (en) * 2000-05-12 2010-08-25 オリンパス株式会社 Foreign material recovery tool
US6520978B1 (en) * 2000-05-15 2003-02-18 Intratherapeutics, Inc. Emboli filter
US6602271B2 (en) 2000-05-24 2003-08-05 Medtronic Ave, Inc. Collapsible blood filter with optimal braid geometry
US6939362B2 (en) * 2001-11-27 2005-09-06 Advanced Cardiovascular Systems, Inc. Offset proximal cage for embolic filtering devices
US6565591B2 (en) 2000-06-23 2003-05-20 Salviac Limited Medical device
JP2003535641A (en) * 2000-06-23 2003-12-02 サルヴィアック・リミテッド Filter element for embolic protection device
US8298257B2 (en) 2000-06-29 2012-10-30 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
US7727243B2 (en) 2000-06-29 2010-06-01 Concentric Medical., Inc. Systems, methods and devices for removing obstructions from a blood vessel
WO2002002162A2 (en) * 2000-06-29 2002-01-10 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
US7766921B2 (en) * 2000-06-29 2010-08-03 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
US7727242B2 (en) 2000-06-29 2010-06-01 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
US7285126B2 (en) * 2000-06-29 2007-10-23 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
AU2001273088A1 (en) 2000-06-30 2002-01-30 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US6575995B1 (en) 2000-07-14 2003-06-10 Advanced Cardiovascular Systems, Inc. Expandable cage embolic material filter system and method
US6679902B1 (en) 2000-07-19 2004-01-20 Advanced Cardiovascular Systems, Inc. Reduced profile delivery sheath for use in interventional procedures
US6740061B1 (en) * 2000-07-28 2004-05-25 Ev3 Inc. Distal protection device
US6527746B1 (en) * 2000-08-03 2003-03-04 Ev3, Inc. Back-loading catheter
US6394978B1 (en) 2000-08-09 2002-05-28 Advanced Cardiovascular Systems, Inc. Interventional procedure expandable balloon expansion enabling system and method
US6485501B1 (en) 2000-08-11 2002-11-26 Cordis Corporation Vascular filter system with guidewire and capture mechanism
US6558405B1 (en) 2000-08-29 2003-05-06 Advanced Cardiovascular Systems, Inc. Embolic filter
US6554849B1 (en) * 2000-09-11 2003-04-29 Cordis Corporation Intravascular embolization device
US6511496B1 (en) 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US8303609B2 (en) 2000-09-29 2012-11-06 Cordis Corporation Coated medical devices
US6616681B2 (en) * 2000-10-05 2003-09-09 Scimed Life Systems, Inc. Filter delivery and retrieval device
DE10049865B8 (en) * 2000-10-09 2008-10-30 Universitätsklinikum Freiburg Device for removing an aortic valve on the human heart by means of a minimally invasive surgical procedure
US6537294B1 (en) 2000-10-17 2003-03-25 Advanced Cardiovascular Systems, Inc. Delivery systems for embolic filter devices
US6893451B2 (en) * 2000-11-09 2005-05-17 Advanced Cardiovascular Systems, Inc. Apparatus for capturing objects beyond an operative site utilizing a capture device delivered on a medical guide wire
US6726703B2 (en) 2000-11-27 2004-04-27 Scimed Life Systems, Inc. Distal protection device and method
WO2002047539A2 (en) * 2000-12-15 2002-06-20 Viacor, Inc. Apparatus and method for replacing aortic valve
US6582448B1 (en) 2000-12-21 2003-06-24 Advanced Cardiovascular Systems, Inc. Vessel occlusion device for embolic protection system
US6574497B1 (en) * 2000-12-22 2003-06-03 Advanced Cardiovascular Systems, Inc. MRI medical device markers utilizing fluorine-19
WO2002094111A2 (en) 2001-01-16 2002-11-28 Incept Llc Vascular device for emboli and thrombi removal
US6663651B2 (en) 2001-01-16 2003-12-16 Incept Llc Systems and methods for vascular filter retrieval
US7169165B2 (en) * 2001-01-16 2007-01-30 Boston Scientific Scimed, Inc. Rapid exchange sheath for deployment of medical devices and methods of use
US6936059B2 (en) * 2001-01-16 2005-08-30 Scimed Life Systems, Inc. Endovascular guidewire filter and methods of use
US6551327B1 (en) * 2001-01-17 2003-04-22 Avtar S. Dhindsa Endoscopic stone extraction device with improved basket
US6743237B2 (en) 2001-01-17 2004-06-01 Innon Holdings, Llc Endoscopic stone extraction device with improved basket
US6689151B2 (en) * 2001-01-25 2004-02-10 Scimed Life Systems, Inc. Variable wall thickness for delivery sheath housing
US20020128680A1 (en) * 2001-01-25 2002-09-12 Pavlovic Jennifer L. Distal protection device with electrospun polymer fiber matrix
US6979343B2 (en) * 2001-02-14 2005-12-27 Ev3 Inc. Rolled tip recovery catheter
US6840950B2 (en) 2001-02-20 2005-01-11 Scimed Life Systems, Inc. Low profile emboli capture device
US6569184B2 (en) 2001-02-27 2003-05-27 Advanced Cardiovascular Systems, Inc. Recovery system for retrieving an embolic protection device
US6974468B2 (en) * 2001-02-28 2005-12-13 Scimed Life Systems, Inc. Filter retrieval catheter
US20020123755A1 (en) * 2001-03-01 2002-09-05 Scimed Life Systems, Inc. Embolic protection filter delivery sheath
US7226464B2 (en) * 2001-03-01 2007-06-05 Scimed Life Systems, Inc. Intravascular filter retrieval device having an actuatable dilator tip
US6562058B2 (en) 2001-03-02 2003-05-13 Jacques Seguin Intravascular filter system
US6579302B2 (en) * 2001-03-06 2003-06-17 Cordis Corporation Total occlusion guidewire device
US6537295B2 (en) 2001-03-06 2003-03-25 Scimed Life Systems, Inc. Wire and lock mechanism
US7214237B2 (en) * 2001-03-12 2007-05-08 Don Michael T Anthony Vascular filter with improved strength and flexibility
US6866677B2 (en) * 2001-04-03 2005-03-15 Medtronic Ave, Inc. Temporary intraluminal filter guidewire and methods of use
US6911036B2 (en) * 2001-04-03 2005-06-28 Medtronic Vascular, Inc. Guidewire apparatus for temporary distal embolic protection
US7044958B2 (en) 2001-04-03 2006-05-16 Medtronic Vascular, Inc. Temporary device for capturing embolic material
US20020161395A1 (en) * 2001-04-03 2002-10-31 Nareak Douk Guide wire apparatus for prevention of distal atheroembolization
US6706055B2 (en) 2001-04-03 2004-03-16 Medtronic Ave Inc. Guidewire apparatus for temporary distal embolic protection
US6818006B2 (en) 2001-04-03 2004-11-16 Medtronic Vascular, Inc. Temporary intraluminal filter guidewire
US6428559B1 (en) 2001-04-03 2002-08-06 Cordis Corporation Removable, variable-diameter vascular filter system
US6623451B2 (en) 2001-05-01 2003-09-23 Scimed Life Systems, Inc. Folding spring for a catheter balloon
US6425882B1 (en) * 2001-05-01 2002-07-30 Interventional Technologies Inc. Folding spring for a catheter balloon
US6635070B2 (en) 2001-05-21 2003-10-21 Bacchus Vascular, Inc. Apparatus and methods for capturing particulate material within blood vessels
US20020183783A1 (en) * 2001-06-04 2002-12-05 Shadduck John H. Guidewire for capturing emboli in endovascular interventions
US20020188314A1 (en) * 2001-06-07 2002-12-12 Microvena Corporation Radiopaque distal embolic protection device
US6596011B2 (en) 2001-06-12 2003-07-22 Cordis Corporation Emboli extraction catheter and vascular filter system
US6575996B1 (en) 2001-06-29 2003-06-10 Advanced Cardiovascular Systems, Inc. Filter device for embolic protection system
US6962598B2 (en) * 2001-07-02 2005-11-08 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection
US6951570B2 (en) * 2001-07-02 2005-10-04 Rubicon Medical, Inc. Methods, systems, and devices for deploying a filter from a filter device
US6878153B2 (en) 2001-07-02 2005-04-12 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
US6997939B2 (en) * 2001-07-02 2006-02-14 Rubicon Medical, Inc. Methods, systems, and devices for deploying an embolic protection filter
BR0210745A (en) * 2001-07-02 2006-10-10 Rubicon Medical Inc methods, systems and devices for employing an embolic protection filter
US20030100945A1 (en) * 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US6656203B2 (en) 2001-07-18 2003-12-02 Cordis Corporation Integral vascular filter system
US20030023263A1 (en) 2001-07-24 2003-01-30 Incept Llc Apparatus and methods for aspirating emboli
US20030023261A1 (en) 2001-07-30 2003-01-30 Scimed Life Systems Inc. Chronic total occlusion device with variable stiffness shaft
US6551342B1 (en) * 2001-08-24 2003-04-22 Endovascular Technologies, Inc. Embolic filter
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US6616682B2 (en) * 2001-09-19 2003-09-09 Jomed Gmbh Methods and apparatus for distal protection during a medical procedure
US20030060843A1 (en) 2001-09-27 2003-03-27 Don Boucher Vascular filter system with encapsulated filter
US6878151B2 (en) 2001-09-27 2005-04-12 Scimed Life Systems, Inc. Medical retrieval device
EP2319453B1 (en) * 2001-09-28 2016-07-20 Boston Scientific Limited A cardiovascular balloon catheter comprising nanocomposites
US6755847B2 (en) 2001-10-05 2004-06-29 Scimed Life Systems, Inc. Emboli capturing device and method of manufacture therefor
US20030069597A1 (en) * 2001-10-10 2003-04-10 Scimed Life Systems, Inc. Loading tool
US6893431B2 (en) * 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches
US20030078614A1 (en) * 2001-10-18 2003-04-24 Amr Salahieh Vascular embolic filter devices and methods of use therefor
US7749243B2 (en) * 2001-10-19 2010-07-06 Boston Scientific Scimed, Inc. Embolus extractor
US20040138692A1 (en) * 2003-01-13 2004-07-15 Scimed Life Systems, Inc. Embolus extractor
US6887257B2 (en) * 2001-10-19 2005-05-03 Incept Llc Vascular embolic filter exchange devices and methods of use thereof
US20030083692A1 (en) * 2001-10-29 2003-05-01 Scimed Life Systems, Inc. Distal protection device and method of use thereof
US6824562B2 (en) 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US6932828B2 (en) 2001-11-06 2005-08-23 Possis Medical, Inc. Guidewire occlusion system utilizing repeatably inflatable gas-filled occlusive device
US20060064071A1 (en) * 2001-11-06 2006-03-23 Possis Medical, Inc. Gas inflation/evacuation system incorporating a reservoir and removably attached sealing system for a guidewire assembly having an occlusive device
US6942678B2 (en) * 2001-11-06 2005-09-13 Possis Medical, Inc. Gas inflation/evacuation system and sealing system for guidewire assembly having occlusive device
US7438710B2 (en) * 2001-11-07 2008-10-21 Anderson Kent D Distal protection device with local drug infusion by physician to maintain patency
AU2002352628B2 (en) 2001-11-09 2006-06-29 Rubicon Medical, Inc. Stent delivery device with embolic protection
US7594926B2 (en) * 2001-11-09 2009-09-29 Boston Scientific Scimed, Inc. Methods, systems and devices for delivering stents
US6755813B2 (en) 2001-11-20 2004-06-29 Cleveland Clinic Foundation Apparatus and method for performing thrombolysis
US6749619B2 (en) 2001-11-20 2004-06-15 The Cleveland Clinic Foundation Apparatus and method for eliminating dislodged thrombus
US6890340B2 (en) * 2001-11-29 2005-05-10 Medtronic Vascular, Inc. Apparatus for temporary intraluminal protection
US20030135266A1 (en) 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7309350B2 (en) 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
US20040186551A1 (en) 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US7892273B2 (en) 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US7351255B2 (en) 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US7137993B2 (en) 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7294146B2 (en) 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
US8080048B2 (en) * 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US7182779B2 (en) 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7147656B2 (en) 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
CA2759746C (en) * 2001-12-05 2018-05-22 Smt Research And Development Ltd. Endovascular device for entrapment of particulate matter and method for use
US7153320B2 (en) * 2001-12-13 2006-12-26 Scimed Life Systems, Inc. Hydraulic controlled retractable tip filter retrieval catheter
US6793666B2 (en) 2001-12-18 2004-09-21 Scimed Life Systems, Inc. Distal protection mechanically attached filter cartridge
US7348055B2 (en) * 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US7322958B2 (en) * 2001-12-27 2008-01-29 Wholey Mark H Apparatus for thromboembolic protection
US6958074B2 (en) 2002-01-07 2005-10-25 Cordis Corporation Releasable and retrievable vascular filter system
US6932830B2 (en) 2002-01-10 2005-08-23 Scimed Life Systems, Inc. Disc shaped filter
US8647359B2 (en) 2002-01-10 2014-02-11 Boston Scientific Scimed, Inc. Distal protection filter
US7247162B1 (en) 2002-01-14 2007-07-24 Edwards Lifesciences Corporation Direct access atherectomy devices
US20030135162A1 (en) 2002-01-17 2003-07-17 Scimed Life Systems, Inc. Delivery and retrieval manifold for a distal protection filter
US7351260B2 (en) 2005-01-20 2008-04-01 Cardiac Dimensions, Inc. Tissue shaping device
US7344549B2 (en) * 2002-01-31 2008-03-18 Advanced Cardiovascular Systems, Inc. Expandable cages for embolic filtering devices
US6763875B2 (en) 2002-02-06 2004-07-20 Andersen Corporation Reduced visibility insect screen
US6997938B2 (en) * 2002-02-12 2006-02-14 Scimed Life Systems, Inc. Embolic protection device
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US7118539B2 (en) * 2002-02-26 2006-10-10 Scimed Life Systems, Inc. Articulating guide wire for embolic protection and methods of use
AU2003209966A1 (en) 2002-03-05 2003-09-16 Salviac Limited An embolic protection system
US7349995B2 (en) * 2002-03-07 2008-03-25 Intel Corporation Computing device with scalable logic block to respond to data transfer requests
US7192434B2 (en) * 2002-03-08 2007-03-20 Ev3 Inc. Vascular protection devices and methods of use
US6773448B2 (en) 2002-03-08 2004-08-10 Ev3 Inc. Distal protection devices having controllable wire motion
US20030176886A1 (en) * 2002-03-12 2003-09-18 Wholey Mark H. Vascular catheter with expanded distal tip for receiving a thromboembolic protection device and method of use
US20030176884A1 (en) * 2002-03-12 2003-09-18 Marwane Berrada Everted filter device
US7029440B2 (en) * 2002-03-13 2006-04-18 Scimed Life Systems, Inc. Distal protection filter and method of manufacture
US20030187495A1 (en) 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
US20030191493A1 (en) * 2002-04-05 2003-10-09 Epstein Gordon H. Device for clot retrieval and distal protection
US20030204168A1 (en) * 2002-04-30 2003-10-30 Gjalt Bosma Coated vascular devices
US8070769B2 (en) * 2002-05-06 2011-12-06 Boston Scientific Scimed, Inc. Inverted embolic protection filter
US7060082B2 (en) * 2002-05-06 2006-06-13 Scimed Life Systems, Inc. Perfusion guidewire in combination with a distal filter
US7585309B2 (en) * 2002-05-16 2009-09-08 Boston Scientific Scimed, Inc. Aortic filter
US7001406B2 (en) * 2002-05-23 2006-02-21 Scimed Life Systems Inc. Cartridge embolic protection filter and methods of use
US7959584B2 (en) 2002-05-29 2011-06-14 Boston Scientific Scimed, Inc. Dedicated distal protection guidewires
US7326224B2 (en) * 2002-06-11 2008-02-05 Boston Scientific Scimed, Inc. Shaft and wire lock
US7717934B2 (en) * 2002-06-14 2010-05-18 Ev3 Inc. Rapid exchange catheters usable with embolic protection devices
US6887258B2 (en) 2002-06-26 2005-05-03 Advanced Cardiovascular Systems, Inc. Embolic filtering devices for bifurcated vessels
US7172614B2 (en) 2002-06-27 2007-02-06 Advanced Cardiovascular Systems, Inc. Support structures for embolic filtering devices
US7166120B2 (en) * 2002-07-12 2007-01-23 Ev3 Inc. Catheter with occluding cuff
US7232452B2 (en) * 2002-07-12 2007-06-19 Ev3 Inc. Device to create proximal stasis
DE10233085B4 (en) 2002-07-19 2014-02-20 Dendron Gmbh Stent with guide wire
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US7303575B2 (en) * 2002-08-01 2007-12-04 Lumen Biomedical, Inc. Embolism protection devices
AU2003259784A1 (en) 2002-08-13 2004-02-25 Cook Ireland Ltd. Ercp catheter with a removable handle for lithotriptor compatible basket
AU2003262938A1 (en) 2002-08-27 2004-03-19 Amir Belson Embolic protection device
US7174636B2 (en) * 2002-09-04 2007-02-13 Scimed Life Systems, Inc. Method of making an embolic filter
AU2003267164A1 (en) * 2002-09-12 2004-04-30 Cook Incorporated Retrievable filter
US20060015136A1 (en) * 2002-09-19 2006-01-19 Memory Metal Holland Bv Vascular filter with improved strength and flexibility
US20040093011A1 (en) * 2002-10-01 2004-05-13 Scimed Life Systems, Inc. Embolic protection device with lesion length assessment markers
US8468678B2 (en) 2002-10-02 2013-06-25 Boston Scientific Scimed, Inc. Expandable retrieval device
US7998163B2 (en) 2002-10-03 2011-08-16 Boston Scientific Scimed, Inc. Expandable retrieval device
AU2003282746A1 (en) * 2002-10-02 2004-04-23 Boston Scientific Limited Expandable retrieval device
US20040093012A1 (en) 2002-10-17 2004-05-13 Cully Edward H. Embolic filter frame having looped support strut elements
US7481823B2 (en) * 2002-10-25 2009-01-27 Boston Scientific Scimed, Inc. Multiple membrane embolic protection filter
WO2004039287A2 (en) * 2002-10-29 2004-05-13 Peacock James C Iii Embolic filter device and related systems and methods
US20040088000A1 (en) 2002-10-31 2004-05-06 Muller Paul F. Single-wire expandable cages for embolic filtering devices
US20040098022A1 (en) * 2002-11-14 2004-05-20 Barone David D. Intraluminal catheter with hydraulically collapsible self-expanding protection device
US7527636B2 (en) * 2002-11-14 2009-05-05 Medtronic Vascular, Inc Intraluminal guidewire with hydraulically collapsible self-expanding protection device
US20040102789A1 (en) * 2002-11-22 2004-05-27 Scimed Life Systems, Inc. Selectively locking device
US20040102806A1 (en) * 2002-11-27 2004-05-27 Scimed Life Systems, Inc. Intravascular filter monitoring
US7206509B2 (en) * 2002-11-29 2007-04-17 Lucent Technologies Inc. Method and apparatus for temporally shifting one or more packets using wavelength selective delays
US20040111111A1 (en) * 2002-12-10 2004-06-10 Scimed Life Systems, Inc. Intravascular filter membrane with shape memory
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US20040116831A1 (en) * 2002-12-13 2004-06-17 Scimed Life Systems, Inc. Distal protection guidewire with nitinol core
JP2004246317A (en) * 2002-12-20 2004-09-02 Hitachi Ltd Cold cathode type flat panel display
US20040186349A1 (en) * 2002-12-24 2004-09-23 Usgi Medical Corp. Apparatus and methods for achieving endoluminal access
US7625389B2 (en) 2002-12-30 2009-12-01 Boston Scientific Scimed, Inc. Embolic protection device
US20040138693A1 (en) * 2003-01-14 2004-07-15 Scimed Life Systems, Inc. Snare retrievable embolic protection filter with guidewire stopper
US20040138694A1 (en) * 2003-01-15 2004-07-15 Scimed Life Systems, Inc. Intravascular filtering membrane and method of making an embolic protection filter device
US7166088B2 (en) 2003-01-27 2007-01-23 Heuser Richard R Catheter introducer system
US20040147955A1 (en) * 2003-01-28 2004-07-29 Scimed Life Systems, Inc. Embolic protection filter having an improved filter frame
US7220271B2 (en) * 2003-01-30 2007-05-22 Ev3 Inc. Embolic filters having multiple layers and controlled pore size
US20040153119A1 (en) * 2003-01-30 2004-08-05 Kusleika Richard S. Embolic filters with a distal loop or no loop
US7323001B2 (en) * 2003-01-30 2008-01-29 Ev3 Inc. Embolic filters with controlled pore size
US7163549B2 (en) 2003-02-11 2007-01-16 Boston Scientific Scimed Inc. Filter membrane manufacturing method
US7285109B2 (en) * 2003-02-13 2007-10-23 Boston Scientific Scimed, Inc. Device and method for collapsing an angioplasty balloon
US7041174B2 (en) * 2003-02-19 2006-05-09 Sunmodics,Inc. Grafting apparatus and method of using
US7740644B2 (en) 2003-02-24 2010-06-22 Boston Scientific Scimed, Inc. Embolic protection filtering device that can be adapted to be advanced over a guidewire
US6878291B2 (en) * 2003-02-24 2005-04-12 Scimed Life Systems, Inc. Flexible tube for cartridge filter
US20040167566A1 (en) * 2003-02-24 2004-08-26 Scimed Life Systems, Inc. Apparatus for anchoring an intravascular device along a guidewire
US7137991B2 (en) * 2003-02-24 2006-11-21 Scimed Life Systems, Inc. Multi-wire embolic protection filtering device
US20050015048A1 (en) * 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
US7250041B2 (en) * 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20040186510A1 (en) * 2003-03-18 2004-09-23 Scimed Life Systems, Inc. Embolic protection ivc filter
US7163550B2 (en) 2003-03-26 2007-01-16 Scimed Life Systems, Inc. Method for manufacturing medical devices from linear elastic materials while maintaining linear elastic properties
US6960370B2 (en) 2003-03-27 2005-11-01 Scimed Life Systems, Inc. Methods of forming medical devices
US20040193208A1 (en) * 2003-03-27 2004-09-30 Scimed Life Systems, Inc. Radiopaque embolic protection filter membrane
US6902572B2 (en) * 2003-04-02 2005-06-07 Scimed Life Systems, Inc. Anchoring mechanisms for intravascular devices
US20040199201A1 (en) * 2003-04-02 2004-10-07 Scimed Life Systems, Inc. Embolectomy devices
US20040199199A1 (en) * 2003-04-02 2004-10-07 Scimed Life Systems, Inc. Filter and method of making a filter
US20040204737A1 (en) * 2003-04-11 2004-10-14 Scimed Life Systems, Inc. Embolic filter loop fabricated from composite material
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7597704B2 (en) * 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US7604649B2 (en) * 2003-04-29 2009-10-20 Rex Medical, L.P. Distal protection device
US7331976B2 (en) * 2003-04-29 2008-02-19 Rex Medical, L.P. Distal protection device
US7780611B2 (en) 2003-05-01 2010-08-24 Boston Scientific Scimed, Inc. Medical instrument with controlled torque transmission
US20040220654A1 (en) 2003-05-02 2004-11-04 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6969396B2 (en) 2003-05-07 2005-11-29 Scimed Life Systems, Inc. Filter membrane with increased surface area
US7241308B2 (en) 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
US20040249409A1 (en) * 2003-06-09 2004-12-09 Scimed Life Systems, Inc. Reinforced filter membrane
US7537600B2 (en) 2003-06-12 2009-05-26 Boston Scientific Scimed, Inc. Valved embolic protection filter
US20040254528A1 (en) * 2003-06-12 2004-12-16 Adams Daniel O. Catheter with removable wire lumen segment
US20050049577A1 (en) * 2003-06-20 2005-03-03 Robert Snell Medical device
US20050004594A1 (en) * 2003-07-02 2005-01-06 Jeffrey Nool Devices and methods for aspirating from filters
US8337519B2 (en) * 2003-07-10 2012-12-25 Boston Scientific Scimed, Inc. Embolic protection filtering device
US8048042B2 (en) * 2003-07-22 2011-11-01 Medtronic Vascular, Inc. Medical articles incorporating surface capillary fiber
US7879062B2 (en) * 2003-07-22 2011-02-01 Lumen Biomedical, Inc. Fiber based embolism protection device
US9301829B2 (en) 2003-07-30 2016-04-05 Boston Scientific Scimed, Inc. Embolic protection aspirator
US7896898B2 (en) * 2003-07-30 2011-03-01 Boston Scientific Scimed, Inc. Self-centering blood clot filter
US7072495B2 (en) * 2003-07-30 2006-07-04 Xerox Corporation System and method for measuring and quantizing document quality
US7731722B2 (en) * 2003-07-31 2010-06-08 Vance Products Incorporated Ureteral backstop filter and retrieval device
US7316692B2 (en) * 2003-08-12 2008-01-08 Boston Scientific Scimed, Inc. Laser-cut clot puller
US8393328B2 (en) 2003-08-22 2013-03-12 BiO2 Medical, Inc. Airway assembly and methods of using an airway assembly
US20050049669A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system with distal protection
JP2007503918A (en) * 2003-09-04 2007-03-01 セカント メディカル エルエルシー Intravascular snare for capturing and removing arterial emboli
US8535344B2 (en) 2003-09-12 2013-09-17 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
US7699865B2 (en) 2003-09-12 2010-04-20 Rubicon Medical, Inc. Actuating constraining mechanism
US7409798B2 (en) * 2003-09-23 2008-08-12 Freeby James L Device for protecting an object from encroaching elements
US20050113804A1 (en) * 2003-10-03 2005-05-26 Von Lehe Cathleen Variable diameter delivery catheter
US7205624B2 (en) * 2003-10-07 2007-04-17 Applied Materials, Inc. Self-aligned implanted waveguide detector
US7371248B2 (en) * 2003-10-14 2008-05-13 Medtronic Vascular, Inc. Steerable distal protection guidewire and methods of use
US7344550B2 (en) * 2003-10-21 2008-03-18 Boston Scientific Scimed, Inc. Clot removal device
US20050085826A1 (en) * 2003-10-21 2005-04-21 Scimed Life Systems, Inc. Unfolding balloon catheter for proximal embolus protection
EP1689482A1 (en) * 2003-10-28 2006-08-16 Peacock, James C., III Embolic filter device and related systems and methods
US6994718B2 (en) * 2003-10-29 2006-02-07 Medtronic Vascular, Inc. Distal protection device for filtering and occlusion
US7220269B1 (en) * 2003-11-06 2007-05-22 Possis Medical, Inc. Thrombectomy catheter system with occluder and method of using same
US8048103B2 (en) * 2003-11-06 2011-11-01 Boston Scientific Scimed, Inc. Flattened tip filter wire design
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
WO2005051206A1 (en) 2003-11-21 2005-06-09 Vnus Medical Technologies, Inc. Method and apparatus for treating a carotid artery
US7716801B2 (en) * 2003-11-24 2010-05-18 Medtronic Vascular, Inc. Low-profile distal protection device
US7651514B2 (en) 2003-12-11 2010-01-26 Boston Scientific Scimed, Inc. Nose rider improvement for filter exchange and methods of use
US20050149110A1 (en) * 2003-12-16 2005-07-07 Wholey Mark H. Vascular catheter with an expandable section and a distal tip for delivering a thromboembolic protection device and method of use
US9526616B2 (en) 2003-12-19 2016-12-27 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US20050159773A1 (en) * 2004-01-20 2005-07-21 Scimed Life Systems, Inc. Expandable retrieval device with dilator tip
US8231649B2 (en) * 2004-01-20 2012-07-31 Boston Scientific Scimed, Inc. Retrievable blood clot filter with retractable anchoring members
US20050159772A1 (en) * 2004-01-20 2005-07-21 Scimed Life Systems, Inc. Sheath for use with an embolic protection filtering device
US7442196B2 (en) * 2004-02-06 2008-10-28 Synvasive Technology, Inc. Dynamic knee balancer
US8764725B2 (en) * 2004-02-09 2014-07-01 Covidien Lp Directional anchoring mechanism, method and applications thereof
US7988705B2 (en) * 2004-03-06 2011-08-02 Lumen Biomedical, Inc. Steerable device having a corewire within a tube and combination with a functional medical component
US8092483B2 (en) * 2004-03-06 2012-01-10 Medtronic, Inc. Steerable device having a corewire within a tube and combination with a functional medical component
US7686825B2 (en) 2004-03-25 2010-03-30 Hauser David L Vascular filter device
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US7172551B2 (en) * 2004-04-12 2007-02-06 Scimed Life Systems, Inc. Cyclical pressure coronary assist pump
US20050240215A1 (en) * 2004-04-21 2005-10-27 Scimed Life Systems, Inc. Magnetic embolic protection device and method
US7799050B2 (en) * 2004-05-05 2010-09-21 Boston Scientific Scimed, Inc. Devices and methods for magnetically manipulating intravascular devices
US20050251198A1 (en) * 2004-05-06 2005-11-10 Scimed Life Systems, Inc. Intravascular filter membrane and method of forming
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US8409237B2 (en) * 2004-05-27 2013-04-02 Medtronic, Inc. Emboli filter export system
US20050277978A1 (en) * 2004-06-09 2005-12-15 Secant Medical, Llc Three-dimensional coils for treatment of vascular aneurysms
US20050283166A1 (en) * 2004-06-17 2005-12-22 Secant Medical, Llc Expandible snare
US8241315B2 (en) 2004-06-24 2012-08-14 Boston Scientific Scimed, Inc. Apparatus and method for treating occluded vasculature
US20060293612A1 (en) * 2004-06-24 2006-12-28 Boston Scientific Scimed, Inc. Apparatus and method for treating occluded vasculature
US7976516B2 (en) * 2004-06-25 2011-07-12 Lumen Biomedical, Inc. Medical device having mechanically interlocked segments
US8317859B2 (en) * 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US20050288766A1 (en) 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US7704267B2 (en) 2004-08-04 2010-04-27 C. R. Bard, Inc. Non-entangling vena cava filter
US7794472B2 (en) 2004-08-11 2010-09-14 Boston Scientific Scimed, Inc. Single wire intravascular filter
DE102004040868A1 (en) * 2004-08-23 2006-03-09 Miloslavski, Elina Device for removing thrombi
US8545418B2 (en) 2004-08-25 2013-10-01 Richard R. Heuser Systems and methods for ablation of occlusions within blood vessels
US20060047301A1 (en) * 2004-09-02 2006-03-02 Ogle Matthew F Emboli removal system with oxygenated flow
US8403955B2 (en) * 2004-09-02 2013-03-26 Lifescreen Sciences Llc Inflatable intravascular filter
US8366735B2 (en) * 2004-09-10 2013-02-05 Penumbra, Inc. System and method for treating ischemic stroke
US20060058837A1 (en) * 2004-09-10 2006-03-16 Arani Bose System and method for treating ischemic stroke
US9655633B2 (en) 2004-09-10 2017-05-23 Penumbra, Inc. System and method for treating ischemic stroke
JP5020821B2 (en) * 2004-09-17 2012-09-05 ニチノル・デベロップメント・コーポレーション Shape memory thin film embolism prevention device
ATE520369T1 (en) * 2004-09-17 2011-09-15 Nitinol Dev Corp SHAPE MEMORY THIN FILM EMBOLIC PROTECTION DEVICE
US20060074440A1 (en) * 2004-09-28 2006-04-06 Garner Dean L Method for implanting a fluid adjustable band
US7824416B2 (en) * 2004-10-06 2010-11-02 Boston Scientific Scimed, Inc. Medical retrieval device
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7621904B2 (en) * 2004-10-21 2009-11-24 Boston Scientific Scimed, Inc. Catheter with a pre-shaped distal tip
US20060095067A1 (en) * 2004-11-01 2006-05-04 Horng-Ban Lin Lubricious filter
US7794473B2 (en) 2004-11-12 2010-09-14 C.R. Bard, Inc. Filter delivery system
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
US20080086110A1 (en) * 2004-11-19 2008-04-10 Galdonik Jason A Extendable Device On An Aspiration Catheter
US9707071B2 (en) 2004-11-24 2017-07-18 Contego Medical Llc Percutaneous transluminal angioplasty device with integral embolic filter
US7429261B2 (en) 2004-11-24 2008-09-30 Ablation Frontiers, Inc. Atrial ablation catheter and method of use
US7468062B2 (en) 2004-11-24 2008-12-23 Ablation Frontiers, Inc. Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use
US8038696B2 (en) 2004-12-06 2011-10-18 Boston Scientific Scimed, Inc. Sheath for use with an embolic protection filter
US20060129181A1 (en) * 2004-12-13 2006-06-15 Callol Joseph R Retrieval device with retractable dilator tip
WO2006074159A2 (en) * 2005-01-03 2006-07-13 Tricardia, Llc Diffusion catheter
WO2006074163A2 (en) * 2005-01-03 2006-07-13 Crux Biomedical, Inc. Retrievable endoluminal filter
US7204464B2 (en) * 2005-01-21 2007-04-17 Boston Scientific Scimed, Inc. Medical wire holder
US8480629B2 (en) 2005-01-28 2013-07-09 Boston Scientific Scimed, Inc. Universal utility board for use with medical devices and methods of use
US8267954B2 (en) 2005-02-04 2012-09-18 C. R. Bard, Inc. Vascular filter with sensing capability
US20060184194A1 (en) * 2005-02-15 2006-08-17 Cook Incorporated Embolic protection device
US7993362B2 (en) * 2005-02-16 2011-08-09 Boston Scientific Scimed, Inc. Filter with positioning and retrieval devices and methods
WO2006089178A2 (en) 2005-02-18 2006-08-24 Ev3 Inc. Rapid exchange catheters and embolic protection devices
US20060190024A1 (en) * 2005-02-24 2006-08-24 Bei Nianjiong Recovery catheter apparatus and method
US8109941B2 (en) 2005-02-28 2012-02-07 Boston Scientific Scimed, Inc. Distal release retrieval assembly and related methods of use
US7998164B2 (en) 2005-03-11 2011-08-16 Boston Scientific Scimed, Inc. Intravascular filter with centering member
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
US20060229657A1 (en) * 2005-03-30 2006-10-12 Wasicek Lawrence D Single operator exchange embolic protection filter
US20070233174A1 (en) * 2005-04-01 2007-10-04 Gordon Hocking Trapping Filter for Blood Vessel
US20060229658A1 (en) * 2005-04-07 2006-10-12 Stivland Timothy M Embolic protection filter with reduced landing zone
US7935075B2 (en) * 2005-04-26 2011-05-03 Cardiac Pacemakers, Inc. Self-deploying vascular occlusion device
US8702744B2 (en) * 2005-05-09 2014-04-22 Nexeon Medsystems, Inc. Apparatus and methods for renal stenting
US7967747B2 (en) * 2005-05-10 2011-06-28 Boston Scientific Scimed, Inc. Filtering apparatus and methods of use
US7967838B2 (en) 2005-05-12 2011-06-28 C. R. Bard, Inc. Removable embolus blood clot filter
US8043323B2 (en) * 2006-10-18 2011-10-25 Inspiremd Ltd. In vivo filter assembly
US8961586B2 (en) * 2005-05-24 2015-02-24 Inspiremd Ltd. Bifurcated stent assemblies
CA2843097C (en) 2005-05-24 2015-10-27 Inspire M.D Ltd. Stent apparatuses for treatment via body lumens and methods of use
US7427288B2 (en) * 2005-06-09 2008-09-23 Medtronic Vascular, Inc. Mechanically expandable distal protection apparatus and method of use
US20060282115A1 (en) * 2005-06-09 2006-12-14 Abrams Robert M Thin film vessel occlusion device
GB0512073D0 (en) * 2005-06-14 2005-07-20 Vallabhaneni Srinivasa R Device for use in treatment of varicose veins
US20060287666A1 (en) * 2005-06-15 2006-12-21 Usgi Medical Inc. Apparatus and methods for endoluminal advancement
US20070005097A1 (en) * 2005-06-20 2007-01-04 Renati Richard J Intravascular filter
EP2759276A1 (en) 2005-06-20 2014-07-30 Medtronic Ablation Frontiers LLC Ablation catheter
US8007508B2 (en) * 2005-07-01 2011-08-30 Cox John A System for tissue dissection and retraction
US8556851B2 (en) * 2005-07-05 2013-10-15 Angioslide Ltd. Balloon catheter
US9439662B2 (en) 2005-07-05 2016-09-13 Angioslide Ltd. Balloon catheter
CA2615267A1 (en) 2005-07-11 2007-01-18 Ablation Frontiers, Inc. Low power tissue ablation system
US20070016242A1 (en) * 2005-07-14 2007-01-18 Israel Henry M Percutaneous device with multiple expandable struts
US20080172066A9 (en) * 2005-07-29 2008-07-17 Galdonik Jason A Embolectomy procedures with a device comprising a polymer and devices with polymer matrices and supports
US8062327B2 (en) 2005-08-09 2011-11-22 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US7938820B2 (en) * 2005-08-18 2011-05-10 Lumen Biomedical, Inc. Thrombectomy catheter
US8021351B2 (en) * 2005-08-18 2011-09-20 Medtronic Vascular, Inc. Tracking aspiration catheter
US8657814B2 (en) 2005-08-22 2014-02-25 Medtronic Ablation Frontiers Llc User interface for tissue ablation system
US20070049964A1 (en) * 2005-08-30 2007-03-01 Medtronic Vascular, Inc. Intraluminal filter for distal protection
US7615031B2 (en) * 2005-09-01 2009-11-10 Medrad, Inc. Gas inflation/evacuation system incorporating a multiple element valved guidewire assembly having an occlusive device
US20070060878A1 (en) 2005-09-01 2007-03-15 Possis Medical, Inc. Occlusive guidewire system having an ergonomic handheld control mechanism and torqueable kink-resistant guidewire
US8608703B2 (en) 2007-06-12 2013-12-17 Medrad, Inc. Infusion flow guidewire system
US20080097294A1 (en) * 2006-02-21 2008-04-24 Possis Medical, Inc. Occlusive guidewire system having an ergonomic handheld control mechanism prepackaged in a pressurized gaseous environment and a compatible prepackaged torqueable kink-resistant guidewire with distal occlusive balloon
US8784860B2 (en) * 2005-10-27 2014-07-22 Cordis Corporation Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
US20070100279A1 (en) * 2005-11-03 2007-05-03 Paragon Intellectual Properties, Llc Radiopaque-balloon microcatheter and methods of manufacture
US20070106320A1 (en) * 2005-11-10 2007-05-10 John Blix Balloon catheter for distal protection compatability
JP2009519731A (en) 2005-11-18 2009-05-21 シー・アール・バード・インコーポレイテツド Vena cava filter with filament
US8052714B2 (en) * 2005-11-22 2011-11-08 Medtronic Vascular, Inc. Radiopaque fibers and filtration matrices
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
US20070149996A1 (en) * 2005-12-28 2007-06-28 Medtronic Vascular, Inc. Low profile filter
US9107733B2 (en) * 2006-01-13 2015-08-18 W. L. Gore & Associates, Inc. Removable blood conduit filter
US7374567B2 (en) 2006-01-25 2008-05-20 Heuser Richard R Catheter system for connecting adjacent blood vessels
US8062321B2 (en) 2006-01-25 2011-11-22 Pq Bypass, Inc. Catheter system for connecting adjacent blood vessels
US7682371B2 (en) * 2006-01-25 2010-03-23 Medtronic Vascular, Inc. Device with actuatable fluid-column occluder for prevention of embolization
US20070179519A1 (en) * 2006-01-27 2007-08-02 Wang Huisun Stent delivery system to improve placement accuracy for self-expanding stent
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
WO2007089897A2 (en) 2006-02-01 2007-08-09 The Cleveland Clinic Foundation Inflatable-deflatable passive exercise unit
US20070225749A1 (en) * 2006-02-03 2007-09-27 Martin Brian B Methods and devices for restoring blood flow within blocked vasculature
US20070185524A1 (en) * 2006-02-03 2007-08-09 Pedro Diaz Rapid exchange emboli capture guidewire system and methods of use
US20070185525A1 (en) * 2006-02-07 2007-08-09 White Bradley R Floating on the wire filter wire
US20080045893A1 (en) * 2006-02-14 2008-02-21 Cardio Exodus, Llc Imageable balloon and method of making
US20070225644A1 (en) * 2006-03-08 2007-09-27 Peter Berger Embolic removal for orthopedic procedures
US8652198B2 (en) 2006-03-20 2014-02-18 J.W. Medical Systems Ltd. Apparatus and methods for deployment of linked prosthetic segments
US8500772B2 (en) * 2006-03-20 2013-08-06 Cook Medical Technologies Llc Distal protection device
US20070219577A1 (en) * 2006-03-20 2007-09-20 Boston Scientific Scimed, Inc. Sprayed in delivery sheath tubes
WO2007126931A2 (en) * 2006-03-31 2007-11-08 Ev3 Inc. Embolic protection devices having radiopaque markers
US7846175B2 (en) * 2006-04-03 2010-12-07 Medrad, Inc. Guidewire and collapsable filter system
US20070239198A1 (en) * 2006-04-03 2007-10-11 Boston Scientific Scimed, Inc. Filter and wire with distal isolation
WO2007133366A2 (en) 2006-05-02 2007-11-22 C. R. Bard, Inc. Vena cava filter formed from a sheet
US20070265655A1 (en) * 2006-05-09 2007-11-15 Boston Scientific Scimed, Inc. Embolic protection filter with enhanced stability within a vessel
US8409238B2 (en) * 2006-05-18 2013-04-02 Boston Scientific Scimed, Inc. Mini cams on support loop for vessel stabilization
CA2655158A1 (en) 2006-06-05 2007-12-13 C.R. Bard Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US20070288054A1 (en) * 2006-06-13 2007-12-13 Tanaka Don A Vascular thrombectomby apparatus and method of use
US20080234722A1 (en) * 2006-06-14 2008-09-25 Possis Medical, Inc. Inferior vena cava filter on guidewire
US8277479B2 (en) * 2006-06-26 2012-10-02 Boston Scientific Scimed, Inc. Self-opening filter with wire actuation
AU2007270693A1 (en) * 2006-07-06 2008-01-10 Angioslide Ltd. Collecting sheath and method of use thereof
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US11285005B2 (en) 2006-07-17 2022-03-29 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US8876754B2 (en) * 2006-08-31 2014-11-04 Bayer Medical Care Inc. Catheter with filtering and sensing elements
US8617204B2 (en) 2006-09-13 2013-12-31 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
WO2008041094A2 (en) * 2006-10-06 2008-04-10 Lithotech Medical Ltd. Retrieval snare for extracting foreign objects from body cavities and method for manufacturing thereof
US9149609B2 (en) * 2006-10-16 2015-10-06 Embolitech, Llc Catheter for removal of an organized embolic thrombus
CA2666728C (en) * 2006-10-18 2015-06-23 Asher Holzer Knitted stent jackets
US20100324664A1 (en) * 2006-10-18 2010-12-23 Asher Holzer Bifurcated Stent Assemblies
EP2083902B1 (en) * 2006-10-18 2017-08-30 Inspiremd Ltd. Filter assemblies
US20080269774A1 (en) 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
EP2088962B1 (en) 2006-11-22 2017-10-11 Inspiremd Ltd. Optimized stent jacket
EP2129425B1 (en) 2006-11-29 2023-12-27 Emboline, INC. Embolic protection device
US20080140003A1 (en) * 2006-12-06 2008-06-12 Advanced Cardiovascular Systems, Inc. Balloon catheter having a regrooming sheath and method for collapsing an expanded medical device
US20080147110A1 (en) * 2006-12-19 2008-06-19 Lalith Hiran Wijeratne Embolic protection device with distal tubular member for improved torque response
EP2114297B1 (en) 2007-02-02 2019-08-21 Covidien LP Embolic protection devices having short landing zones
US20080199510A1 (en) 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
JP2010522601A (en) * 2007-03-27 2010-07-08 イントラテック メディカル リミテッド Spiral balloon catheter
US7780630B2 (en) * 2007-03-30 2010-08-24 Boston Scientific Scimed, Inc. Perfusion device
US7686783B2 (en) * 2007-03-30 2010-03-30 Boston Scientific Scimed, Inc. Perfusion and embolic protection
US20080243170A1 (en) * 2007-03-30 2008-10-02 Boston Scientific Scimed, Inc. Embolic capturing devices and methods
US11202646B2 (en) 2007-04-17 2021-12-21 Covidien Lp Articulating retrieval devices
US10064635B2 (en) * 2007-04-17 2018-09-04 Covidien Lp Articulating retrieval devices
US8512352B2 (en) 2007-04-17 2013-08-20 Lazarus Effect, Inc. Complex wire formed devices
US10076346B2 (en) 2007-04-17 2018-09-18 Covidien Lp Complex wire formed devices
AU2008246928B2 (en) * 2007-05-07 2014-04-17 Protalix Ltd. Large scale disposable bioreactor
US8641704B2 (en) 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
EP2167180B1 (en) * 2007-06-01 2015-03-04 Covidien LP Extension tubes for balloon catheters
US9669191B2 (en) 2008-02-05 2017-06-06 Silk Road Medical, Inc. Interventional catheter system and methods
US8858490B2 (en) 2007-07-18 2014-10-14 Silk Road Medical, Inc. Systems and methods for treating a carotid artery
US8545432B2 (en) 2009-06-03 2013-10-01 Silk Road Medical, Inc. System and methods for controlling retrograde carotid arterial blood flow
WO2009012473A2 (en) 2007-07-18 2009-01-22 Silk Road Medical, Inc. Methods and systems for establishing retrograde carotid arterial blood flow
US8066731B2 (en) 2007-08-20 2011-11-29 Olympus Medical Systems Corp. Treatment device
US9039728B2 (en) 2007-08-31 2015-05-26 BiO2 Medical, Inc. IVC filter catheter with imaging modality
US10376685B2 (en) 2007-08-31 2019-08-13 Mermaid Medical Vascular Aps Thrombus detection device and method
US8613753B2 (en) 2007-08-31 2013-12-24 BiO2 Medical, Inc. Multi-lumen central access vena cava filter apparatus and method of using same
US8668712B2 (en) 2007-08-31 2014-03-11 BiO2 Medical, Inc. Multi-lumen central access vena cava filter apparatus and method of using same
US9687333B2 (en) 2007-08-31 2017-06-27 BiO2 Medical, Inc. Reduced profile central venous access catheter with vena cava filter and method
US8100855B2 (en) * 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
US20090099590A1 (en) * 2007-10-11 2009-04-16 Lalith Hiran Wijeratne Embolic protection device having a filter frame with integral distal strain relief
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
US8926680B2 (en) 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US9220522B2 (en) 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US9198687B2 (en) 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US8066757B2 (en) 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
EP2211972B1 (en) * 2007-10-26 2015-12-23 Embolitech, LLC Intravascular guidewire filter system for pulmonary embolism protection and embolism removal or maceration
US9050004B2 (en) 2007-12-07 2015-06-09 Socorro Medical, Inc. Endoscopic system for accessing constrained surgical spaces
AU2008345624B2 (en) * 2007-12-19 2014-05-08 Covidien Lp Improved devices and methods for embolus removal during acute ischemic stroke
WO2009086482A1 (en) 2007-12-26 2009-07-09 Lazarus Effect, Inc. Retrieval systems and methods for use thereof
US8435237B2 (en) 2008-01-29 2013-05-07 Covidien Lp Polyp encapsulation system and method
BRPI0908500A8 (en) 2008-02-22 2018-10-23 Micro Therapeutics Inc imaging methods of restoration of thrombus-occluded blood vessel blood flow, partial or substantial dissolution and thrombus dislocation, self-expanding thrombus removal equipment and integrated removable thrombus mass
US9101503B2 (en) 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
US20090248059A1 (en) * 2008-03-25 2009-10-01 Hesham Morsi Embolectomy Catheter
WO2009126935A2 (en) 2008-04-11 2009-10-15 Mindframe, Inc. Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
US20090292307A1 (en) * 2008-05-22 2009-11-26 Nasser Razack Mechanical embolectomy device and method
EP2303384B1 (en) 2008-06-23 2015-08-12 Lumen Biomedical, Inc. Embolic protection during percutaneous heart valve replacement and similar procedures
JP2011526529A (en) 2008-07-02 2011-10-13 アンジオスライド リミテッド Balloon catheter system and method of use thereof
US8052717B2 (en) * 2008-07-14 2011-11-08 Boston Scientific Scimed, Inc. Embolic protection device
US8070694B2 (en) * 2008-07-14 2011-12-06 Medtronic Vascular, Inc. Fiber based medical devices and aspiration catheters
US9402707B2 (en) 2008-07-22 2016-08-02 Neuravi Limited Clot capture systems and associated methods
CA2733568C (en) * 2008-08-14 2017-03-07 Benjamin F. Merrifield Apparatus and methods for retrieving an object from a body passage
DE102008038195A1 (en) 2008-08-19 2010-02-25 Phenox Gmbh Device for opening occluded blood vessels
ATE534336T1 (en) 2008-08-29 2011-12-15 Rapid Medical Ltd EMBOLECTOMY DEVICE
CN102149421B (en) * 2008-09-09 2014-12-10 普尔蒙克斯股份有限公司 Systems and methods for inhibiting secretion flow into a functional assessment catheter
US8769796B2 (en) 2008-09-25 2014-07-08 Advanced Bifurcation Systems, Inc. Selective stent crimping
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
CA2739007C (en) 2008-09-25 2017-10-31 Advanced Bifurcation Systems Inc. Partially crimped stent
US8979917B2 (en) 2008-09-25 2015-03-17 Advanced Bifurcation Systems, Inc. System and methods for treating a bifurcation
CA2962054C (en) 2008-11-12 2019-08-06 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20100152711A1 (en) * 2008-12-15 2010-06-17 Boston Scientific Scimed, Inc. Offset coupling region
US8444669B2 (en) 2008-12-15 2013-05-21 Boston Scientific Scimed, Inc. Embolic filter delivery system and method
JP2012513292A (en) 2008-12-23 2012-06-14 シルク・ロード・メディカル・インコーポレイテッド Method and system for treating acute ischemic stroke
EP2387427B1 (en) 2009-01-16 2014-08-27 Claret Medical, Inc. Intravascular blood filter
US9326843B2 (en) 2009-01-16 2016-05-03 Claret Medical, Inc. Intravascular blood filters and methods of use
US20170202657A1 (en) 2009-01-16 2017-07-20 Claret Medical, Inc. Intravascular blood filters and methods of use
US20100185179A1 (en) * 2009-01-21 2010-07-22 Abbott Cardiovascular Systems Inc. Needled cannula with filter device
WO2010088520A2 (en) * 2009-01-29 2010-08-05 Claret Medical, Inc. Illuminated intravascular blood filter
US20100204672A1 (en) * 2009-02-12 2010-08-12 Penumra, Inc. System and method for treating ischemic stroke
US8740930B2 (en) * 2009-02-25 2014-06-03 Medtronic Vascular, Inc. Embolic filter device independent of treatment device
EP2403583B1 (en) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Retrieval systems
EP2417361A4 (en) 2009-04-06 2014-12-10 Univ Vanderbilt High energy density elastic accumulator and method of use thereof
DE102009017050B4 (en) * 2009-04-09 2016-09-01 Acandis Gmbh & Co. Kg Device for removing concrements from body vessels
EP2241284B1 (en) 2009-04-15 2012-09-19 National University of Ireland, Galway Intravasculature devices and balloons for use therewith
WO2010119445A1 (en) * 2009-04-16 2010-10-21 Assis Medical Ltd. Guide wire for stabilizing a catheter with respect to target tissue
US10772717B2 (en) 2009-05-01 2020-09-15 Endologix, Inc. Percutaneous method and device to treat dissections
EP2424447A2 (en) 2009-05-01 2012-03-07 Endologix, Inc. Percutaneous method and device to treat dissections
US20100286722A1 (en) * 2009-05-11 2010-11-11 Intersect Partners, Llc Temporary venous filter system
WO2011017103A2 (en) 2009-07-27 2011-02-10 Claret Medical, Inc. Dual endovascular filter and methods of use
JP5588511B2 (en) 2009-07-27 2014-09-10 エンドロジックス、インク Stent graft
EP3505136A1 (en) 2009-07-29 2019-07-03 C.R. Bard Inc. Tubular filter
US20110054593A1 (en) * 2009-08-28 2011-03-03 Boston Scientific Scimed, Inc. Sheathless embolic protection device
EP3925572A1 (en) 2009-09-21 2021-12-22 Boston Scientific Scimed Inc. Intravascular blood filters
WO2011056981A2 (en) 2009-11-04 2011-05-12 Nitinol Devices And Components, Inc. Alternating circumferential bridge stent design and methods for use thereof
DE102009052002B4 (en) * 2009-11-05 2012-09-27 Acandis Gmbh & Co. Kg A medical device for recanalizing body cavities and set comprising such device
US8696698B2 (en) 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
US9675780B2 (en) 2010-01-19 2017-06-13 Angioslide Ltd. Balloon catheter system and methods of making and use thereof
US8801748B2 (en) 2010-01-22 2014-08-12 Lazarus Effect, Inc. Retrieval systems and methods for use thereof
US8409217B2 (en) 2010-01-25 2013-04-02 Ethicon Endo-Surgery, Inc. Tissue retrieval device with bladders
US8425533B2 (en) 2010-01-26 2013-04-23 Ethicon Endo-Surgery, Inc. Tissue retrieval device with pouch stretching arm
US8414596B2 (en) 2010-01-26 2013-04-09 Ethicon Endo-Surgery, Inc. Tissue retrieval device with gusseted pouch
US8419749B2 (en) 2010-01-26 2013-04-16 Ethicon Endo-Surgery, Inc. Tissue retrieval device with reinforced pouch and variable volume
US20110190781A1 (en) * 2010-02-03 2011-08-04 Nicholas John Collier Surgical retrieval apparatus
CA2804254C (en) 2010-02-23 2016-11-01 Medina Medical, Inc. Devices and methods for vascular recanalization
AU2011232360B2 (en) 2010-03-24 2015-10-08 Advanced Bifurcation Systems Inc. Methods and systems for treating a bifurcation with provisional side branch stenting
WO2011119883A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
WO2011128860A2 (en) * 2010-04-13 2011-10-20 Johan Frederik Schutte Cleaning of swimming pools
WO2011130256A2 (en) 2010-04-13 2011-10-20 Lumen Biomedical, Inc. Embolectomy devices and methods for treatment of acute ischemic stroke condition
JP5611451B2 (en) * 2010-05-11 2014-10-22 クック メディカル テクノロジーズ エルエルシーCook Medical Technologies Llc Bile duct access sheath
WO2012009675A2 (en) 2010-07-15 2012-01-19 Lazarus Effect, Inc. Retrieval systems and methods for use thereof
US9561094B2 (en) 2010-07-23 2017-02-07 Nfinium Vascular Technologies, Llc Devices and methods for treating venous diseases
JP5877294B2 (en) 2010-08-12 2016-03-08 ボストン サイエンティフィック リミテッド Infusion flow system and fluid coupling
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
WO2012047308A1 (en) 2010-10-08 2012-04-12 Nitinol Devices And Components, Inc. Alternating circumferential bridge stent design and methods for use thereof
WO2012052982A1 (en) 2010-10-22 2012-04-26 Neuravi Limited Clot engagement and removal system
WO2012068298A1 (en) 2010-11-17 2012-05-24 Endologix, Inc. Devices and methods to treat vascular dissections
DE102010051740A1 (en) 2010-11-19 2012-05-24 Phenox Gmbh thrombectomy
US9770319B2 (en) 2010-12-01 2017-09-26 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US10022179B2 (en) * 2010-12-14 2018-07-17 Ethicon, Inc. Bipolar medical devices for extracting tissue and methods therefor
WO2012092377A1 (en) 2010-12-30 2012-07-05 Claret Medical, Inc. Intravascular blood filters and methods of use
US8948848B2 (en) 2011-01-07 2015-02-03 Innovative Cardiovascular Solutions, Llc Angiography catheter
US10022212B2 (en) * 2011-01-13 2018-07-17 Cook Medical Technologies Llc Temporary venous filter with anti-coagulant delivery method
US8434524B2 (en) * 2011-01-31 2013-05-07 Vanderbilt University Elastic hydraulic accumulator/reservoir system
CA2826350A1 (en) 2011-02-03 2012-08-09 Vanderbilt University Multiple accumulator systems and methods of use thereof
EP2672925B1 (en) 2011-02-08 2017-05-03 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations
EP2672932B1 (en) 2011-02-08 2018-09-19 Advanced Bifurcation Systems, Inc. System for treating a bifurcation with a fully crimped stent
US8821478B2 (en) 2011-03-04 2014-09-02 Boston Scientific Scimed, Inc. Catheter with variable stiffness
US11259824B2 (en) 2011-03-09 2022-03-01 Neuravi Limited Clot retrieval device for removing occlusive clot from a blood vessel
EP2683309B1 (en) 2011-03-09 2021-04-21 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
DE102011101522A1 (en) 2011-05-13 2012-11-15 Phenox Gmbh thrombectomy
EP3741314B1 (en) 2011-05-23 2022-12-21 Covidien LP Retrieval systems
US11026708B2 (en) 2011-07-26 2021-06-08 Thrombx Medical, Inc. Intravascular thromboembolectomy device and method using the same
EP4101399A1 (en) 2011-08-05 2022-12-14 Route 92 Medical, Inc. System for treatment of acute ischemic stroke
US10779855B2 (en) 2011-08-05 2020-09-22 Route 92 Medical, Inc. Methods and systems for treatment of acute ischemic stroke
US9089668B2 (en) 2011-09-28 2015-07-28 Surefire Medical, Inc. Flow directional infusion device
US8702747B2 (en) 2011-10-21 2014-04-22 Cook Medical Technologies Llc Femoral removal vena cava filter
KR20140109924A (en) 2011-12-03 2014-09-16 아우로보로스 메디컬, 아이엔씨 Safe cutting heads and systems for fast removal of a target tissue
US9249847B2 (en) 2011-12-16 2016-02-02 Vanderbilt University Distributed piston elastomeric accumulator
RU2014129392A (en) 2012-01-06 2016-02-27 Эмболайн, Инк. Embedded anti-embolic protection
US10548706B2 (en) 2012-01-13 2020-02-04 Volcano Corporation Retrieval snare device and method
US10426501B2 (en) 2012-01-13 2019-10-01 Crux Biomedical, Inc. Retrieval snare device and method
WO2013109623A1 (en) 2012-01-17 2013-07-25 Lumen Biomedical, Inc. Aortic arch filtration system for carotid artery protection
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
US10213288B2 (en) 2012-03-06 2019-02-26 Crux Biomedical, Inc. Distal protection filter
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9452047B2 (en) * 2012-04-05 2016-09-27 Medtronic Vascular Galway Heart valve prosthesis recapture devices
EP2844163A4 (en) * 2012-04-30 2015-09-23 Bio2 Medical Inc Multi-lumen central access vena cava filter apparatus for clot management and method of using same
US9408662B2 (en) 2012-05-07 2016-08-09 Cook Medical Technologies Llc Sphincterotome having expandable tines
JP6220386B2 (en) 2012-05-14 2017-10-25 シー・アール・バード・インコーポレーテッドC R Bard Incorporated Uniformly expandable stent
US9888994B2 (en) * 2012-05-15 2018-02-13 Transverse Medical, Inc. Catheter-based apparatuses and methods
US9358022B2 (en) * 2012-05-21 2016-06-07 Noha, Llc Clot removal device and method of using same
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
JP6549482B2 (en) 2012-06-01 2019-07-24 サーモディクス,インコーポレイテッド Device and method for coating a balloon catheter
US9308007B2 (en) 2012-08-14 2016-04-12 W. L. Gore & Associates, Inc. Devices and systems for thrombus treatment
PT2897536T (en) 2012-09-24 2020-11-12 Inari Medical Inc Device and method for treating vascular occlusion
WO2014061013A1 (en) * 2012-10-16 2014-04-24 Keystone Heart Ltd. Interlaced particulate filter
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
US8784434B2 (en) 2012-11-20 2014-07-22 Inceptus Medical, Inc. Methods and apparatus for treating embolism
US20140142688A1 (en) * 2012-11-20 2014-05-22 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering a Medical Device
EP2928537A4 (en) 2012-12-04 2016-08-03 Angioslide Ltd Balloon catheter and methods of use thereof
BR112015013136B1 (en) * 2012-12-21 2021-08-31 The Regents Of The University Of California IN VIVO POSITIONABLE FILTER DEVICES
USD723165S1 (en) 2013-03-12 2015-02-24 C. R. Bard, Inc. Stent
US10076404B2 (en) * 2013-03-12 2018-09-18 Boston Scientific Limited Catheter system with balloon-operated filter sheath and fluid flow maintenance
US9642635B2 (en) 2013-03-13 2017-05-09 Neuravi Limited Clot removal device
TR201820525T4 (en) 2013-03-14 2019-01-21 Neuravi Ltd A clot removal device for removing an occlusive clot from a blood vessel.
US10292677B2 (en) 2013-03-14 2019-05-21 Volcano Corporation Endoluminal filter having enhanced echogenic properties
WO2014140092A2 (en) 2013-03-14 2014-09-18 Neuravi Limited Devices and methods for removal of acute blockages from blood vessels
US10219887B2 (en) 2013-03-14 2019-03-05 Volcano Corporation Filters with echogenic characteristics
JP6342984B2 (en) 2013-03-14 2018-06-13 ボルケーノ コーポレイション Filter with echogenic properties
US9433429B2 (en) 2013-03-14 2016-09-06 Neuravi Limited Clot retrieval devices
US9986967B2 (en) * 2013-03-15 2018-06-05 Volcano Corporation Distal protection systems and methods with pressure and ultrasound features
AU2014237626A1 (en) * 2013-03-15 2015-10-01 Contego Medical, Llc Percutaneous transluminal angioplasty device with integral embolic filter
US9833252B2 (en) * 2013-03-15 2017-12-05 Microvention, Inc. Multi-component obstruction removal system and method
WO2014185969A2 (en) 2013-05-14 2014-11-20 Transverse Medical, Inc. Catheter-based apparatuses and methods
US9867630B2 (en) 2013-06-11 2018-01-16 Innon Holdings, Llc Endoscopic stone-extraction device
CA2913773C (en) 2013-06-14 2021-10-19 Avantec Vascular Corporation Inferior vena cava filter and retrieval systems
WO2015009763A1 (en) 2013-07-19 2015-01-22 Ouroboros Medical, Inc. An anti-clogging device for a vacuum-assisted, tissue removal system
US10070853B2 (en) 2013-08-14 2018-09-11 Covidien Lp Expandable balloon desufflation assembly
US10076399B2 (en) 2013-09-13 2018-09-18 Covidien Lp Endovascular device engagement
US10350098B2 (en) 2013-12-20 2019-07-16 Volcano Corporation Devices and methods for controlled endoluminal filter deployment
EP3082619A4 (en) 2013-12-20 2017-07-26 Microvention, Inc. Vascular occlusion
US9265512B2 (en) 2013-12-23 2016-02-23 Silk Road Medical, Inc. Transcarotid neurovascular catheter
US10285720B2 (en) 2014-03-11 2019-05-14 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
US9820761B2 (en) 2014-03-21 2017-11-21 Route 92 Medical, Inc. Rapid aspiration thrombectomy system and method
US9241699B1 (en) 2014-09-04 2016-01-26 Silk Road Medical, Inc. Methods and devices for transcarotid access
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US9889031B1 (en) 2014-03-25 2018-02-13 Surefire Medical, Inc. Method of gastric artery embolization
US20170119410A1 (en) * 2014-04-29 2017-05-04 Board Of Regents Of The University Of Nebraska Surgical Snare Device
EP3151904A4 (en) 2014-06-04 2018-02-14 Nfinium Vascular Technologies, LLC Low radial force vascular device and method of occlusion
US9655634B2 (en) 2014-06-12 2017-05-23 Innon Holdings, Llc Endoscopic stone-extraction device
US10448962B2 (en) 2014-06-12 2019-10-22 Innon Holdings, Llc Endoscopic stone-extraction device
US10792056B2 (en) 2014-06-13 2020-10-06 Neuravi Limited Devices and methods for removal of acute blockages from blood vessels
US10441301B2 (en) 2014-06-13 2019-10-15 Neuravi Limited Devices and methods for removal of acute blockages from blood vessels
US10265086B2 (en) 2014-06-30 2019-04-23 Neuravi Limited System for removing a clot from a blood vessel
CN104095665B (en) * 2014-07-15 2016-06-08 中国人民解放军第二军医大学 Membrane type ureteral calculus stops taking-up device
CN104095668B (en) * 2014-07-15 2016-08-24 中国人民解放军第二军医大学 Special-shaped ball bellows ureteral calculus stops extractor
US11027104B2 (en) 2014-09-04 2021-06-08 Silk Road Medical, Inc. Methods and devices for transcarotid access
CN108578013B (en) * 2014-09-14 2020-06-16 艾姆伯莱恩公司 Introducer sheath with embolic protection
US20160089172A1 (en) * 2014-09-30 2016-03-31 Boston Scientific Scimed, Inc. Devices and methods for applying suction
US10463351B2 (en) * 2014-10-15 2019-11-05 Cook Medical Technologies Llc Transitional geometry for an expandable medical device
WO2016073530A1 (en) 2014-11-04 2016-05-12 Avantec Vascular Corporation Catheter device with longitudinally expanding interior components for compressing cancellous bone
EP3017775A1 (en) * 2014-11-07 2016-05-11 National University of Ireland, Galway A thrombectomy device
ES2920773T3 (en) 2014-11-26 2022-08-09 Neuravi Ltd A clot removal device to remove an occlusive clot from a blood vessel
US11253278B2 (en) 2014-11-26 2022-02-22 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
US10617435B2 (en) 2014-11-26 2020-04-14 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
WO2016094676A1 (en) * 2014-12-12 2016-06-16 Avantec Vascular Corporation Ivc filter retrieval systems with interposed support members
US10278804B2 (en) 2014-12-12 2019-05-07 Avantec Vascular Corporation IVC filter retrieval systems with releasable capture feature
US10292805B2 (en) 2015-01-23 2019-05-21 Contego Medical, Llc Interventional device having an integrated embolic filter and associated methods
ES2770321T3 (en) 2015-02-04 2020-07-01 Route 92 Medical Inc Rapid Aspiration Thrombectomy System
US11065019B1 (en) 2015-02-04 2021-07-20 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
WO2016130647A1 (en) 2015-02-11 2016-08-18 Lazarus Effect, Inc. Expandable tip medical devices and methods
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
US9566144B2 (en) 2015-04-22 2017-02-14 Claret Medical, Inc. Vascular filters, deflectors, and methods
GB2538072B (en) * 2015-05-05 2017-11-15 Strait Access Tech Holdings (Pty) Ltd A non-occlusive dilation and deployment catheter device
WO2017019563A1 (en) 2015-07-24 2017-02-02 Route 92 Medical, Inc. Anchoring delivery system and methods
EP3324863B1 (en) 2015-07-24 2023-09-27 Ichor Vascular Inc. Embolectomy system
EP3344184A4 (en) 2015-09-01 2019-05-15 Mivi Neuroscience, Inc. Thrombectomy devices and treatment of acute ischemic stroke with thrombus engagement
WO2017058280A1 (en) * 2015-09-28 2017-04-06 GW Medical LLC Mechanical thrombectomy apparatuses and methods
US10342571B2 (en) 2015-10-23 2019-07-09 Inari Medical, Inc. Intravascular treatment of vascular occlusion and associated devices, systems, and methods
US9700332B2 (en) 2015-10-23 2017-07-11 Inari Medical, Inc. Intravascular treatment of vascular occlusion and associated devices, systems, and methods
US20170119408A1 (en) 2015-10-31 2017-05-04 Neurovasc Technologies, Inc. Embolus Removal Device with Blood Flow Restriction and Related Methods
US10716915B2 (en) 2015-11-23 2020-07-21 Mivi Neuroscience, Inc. Catheter systems for applying effective suction in remote vessels and thrombectomy procedures facilitated by catheter systems
CN105662647B (en) * 2016-02-19 2017-11-17 杭州启明医疗器械有限公司 Thrombus filter
EP3448277B1 (en) 2016-04-25 2022-07-06 Stryker Corporation Pre-loaded inverting tractor thrombectomy apparatuses
US10888342B2 (en) 2016-04-25 2021-01-12 Stryker Corporation Anti-jamming and macerating thrombectomy apparatuses and methods
US11497512B2 (en) 2016-04-25 2022-11-15 Stryker Corporation Inverting thrombectomy apparatuses and methods
WO2017189591A1 (en) 2016-04-25 2017-11-02 Stryker Corporation Inverting mechanical thrombectomy apparatuses and methods of use in the vasculature
US11896247B2 (en) 2016-04-25 2024-02-13 Stryker Corporation Inverting mechanical thrombectomy apparatuses
EP4094699A1 (en) 2016-06-03 2022-11-30 Stryker Corporation Inverting thrombectomy apparatuses
JP7086935B2 (en) 2016-08-17 2022-06-20 ニューラヴィ・リミテッド Thrombus recovery system for removing thromboangiitis obliterans from blood vessels
AU2017324233A1 (en) 2016-09-06 2019-04-04 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
EP3509507A1 (en) 2016-09-12 2019-07-17 Stryker Corporation Self-rolling thrombectomy apparatuses and methods
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
JP6789386B2 (en) * 2016-09-19 2020-11-25 シーティーアイ バスキュラー アーゲーCTI Vascular AG Catheter system for treating vascular and non-vascular diseases
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
JP7091320B2 (en) 2016-10-06 2022-06-27 ミビ・ニューロサイエンス・インコーポレイテッド Catheter for performing hydraulic displacement and removal of thrombotic clots, as well as hydraulic displacement
US11737769B2 (en) 2016-12-20 2023-08-29 Omar M. Lattouf Clot retrievers and methods for deployment
CN110167482A (en) 2016-12-22 2019-08-23 阿万泰血管公司 The systems, devices and methods for being used to fetch system with tether
EP3568186B1 (en) 2017-01-10 2022-09-14 Route 92 Medical, Inc. Aspiration catheter systems
US10098651B2 (en) 2017-01-10 2018-10-16 Inari Medical, Inc. Devices and methods for treating vascular occlusion
US11337790B2 (en) 2017-02-22 2022-05-24 Boston Scientific Scimed, Inc. Systems and methods for protecting the cerebral vasculature
US11744692B2 (en) * 2017-02-23 2023-09-05 Boston Scientific Scimed, Inc. Medical drain device
US10390953B2 (en) 2017-03-08 2019-08-27 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
US11129630B2 (en) 2017-05-12 2021-09-28 Covidien Lp Retrieval of material from vessel lumens
US11191555B2 (en) 2017-05-12 2021-12-07 Covidien Lp Retrieval of material from vessel lumens
US11298145B2 (en) 2017-05-12 2022-04-12 Covidien Lp Retrieval of material from vessel lumens
US10709464B2 (en) 2017-05-12 2020-07-14 Covidien Lp Retrieval of material from vessel lumens
US10722257B2 (en) 2017-05-12 2020-07-28 Covidien Lp Retrieval of material from vessel lumens
US11234723B2 (en) 2017-12-20 2022-02-01 Mivi Neuroscience, Inc. Suction catheter systems for applying effective aspiration in remote vessels, especially cerebral arteries
US10478535B2 (en) 2017-05-24 2019-11-19 Mivi Neuroscience, Inc. Suction catheter systems for applying effective aspiration in remote vessels, especially cerebral arteries
WO2018232044A1 (en) 2017-06-12 2018-12-20 Covidien Lp Tools for sheathing treatment devices and associated systems and methods
US10478322B2 (en) 2017-06-19 2019-11-19 Covidien Lp Retractor device for transforming a retrieval device from a deployed position to a delivery position
US10575864B2 (en) 2017-06-22 2020-03-03 Covidien Lp Securing element for resheathing an intravascular device and associated systems and methods
WO2019050765A1 (en) 2017-09-06 2019-03-14 Inari Medical, Inc. Hemostasis valves and methods of use
CN111565653A (en) 2017-09-11 2020-08-21 斯若姆布科思医疗股份有限公司 Intravascular thromboembolic ablation device and method
US20190110804A1 (en) 2017-10-16 2019-04-18 Michael Bruce Horowitz Catheter based retrieval device with proximal body having axial freedom of movement
US20220104839A1 (en) 2017-10-16 2022-04-07 Retriever Medical, Inc. Clot Removal Methods and Devices with Multiple Independently Controllable Elements
CA3195810A1 (en) 2017-10-16 2022-04-21 Michael Bruce Horowitz Clot removal methods and devices with multiple independently controllable elements
CN111565673A (en) 2017-10-27 2020-08-21 波士顿科学医学有限公司 System and method for protecting cerebral blood vessels
US10105154B1 (en) 2017-11-09 2018-10-23 Pebble Hill Partners, Llc Basket for a catheter device
EP3706650B1 (en) 2017-11-09 2022-11-30 Stryker Corporation Inverting thrombectomy apparatuses having enhanced tracking
EP3727192B1 (en) 2017-12-19 2023-03-08 Boston Scientific Scimed, Inc. System for protecting the cerebral vasculature
US11490923B2 (en) 2018-01-05 2022-11-08 Cook Medical Technologies Llc Device with sharp and blunt regions for removing occlusions
US11154314B2 (en) 2018-01-26 2021-10-26 Inari Medical, Inc. Single insertion delivery system for treating embolism and associated systems and methods
WO2019161072A1 (en) * 2018-02-14 2019-08-22 Boston Scientific Scimed, Inc. Occlusive medical device
CA3092870A1 (en) 2018-03-07 2019-09-12 Innovative Cardiovascular Solutions, Llc Embolic protection device
DE102018105671A1 (en) 2018-03-12 2019-09-12 Phenox Gmbh thrombectomy
WO2019178165A1 (en) * 2018-03-12 2019-09-19 Xtract Medical Devices and methods for removing material from a patient
US11439491B2 (en) 2018-04-26 2022-09-13 Claret Medical, Inc. Systems and methods for protecting the cerebral vasculature
EP3790502A1 (en) 2018-05-09 2021-03-17 Boston Scientific Scimed, Inc. Pedal access embolic filtering sheath
US11103265B2 (en) 2018-05-14 2021-08-31 Stryker Corporation Inverting thrombectomy apparatuses and methods of use
WO2019222425A1 (en) * 2018-05-14 2019-11-21 Kassab Ghassan S Devices, systems, and methods for locally engaging tissue using suction
AU2019269606A1 (en) 2018-05-17 2020-12-03 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
US20210298890A1 (en) * 2018-06-27 2021-09-30 Cirlo Gmbh Implants for recruiting and removing circulating tumor cells
WO2020006451A1 (en) 2018-06-29 2020-01-02 Avantec Vascular Corporation Systems and methods for implants and deployment devices
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
EP3836855A4 (en) 2018-08-13 2022-08-10 Inari Medical, Inc. System for treating embolism and associated devices and methods
JP2021535778A (en) 2018-08-21 2021-12-23 ボストン サイエンティフィック サイムド, インコーポレイテッドBoston Scientific Scimed, Inc. A system to protect the cerebrovascular system
EP3984477B1 (en) 2018-09-10 2023-07-19 Stryker Corporation Inverting thrombectomy apparatuses
WO2020055866A1 (en) 2018-09-10 2020-03-19 Stryker Corporation Laser slotted grabbing device
US10842498B2 (en) 2018-09-13 2020-11-24 Neuravi Limited Systems and methods of restoring perfusion to a vessel
US11389284B2 (en) 2018-09-28 2022-07-19 Boston Scientific Scimed, Inc. Embolic protection devices
US11406416B2 (en) 2018-10-02 2022-08-09 Neuravi Limited Joint assembly for vasculature obstruction capture device
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
US11564692B2 (en) 2018-11-01 2023-01-31 Terumo Corporation Occlusion systems
US11253279B2 (en) * 2018-11-15 2022-02-22 Progressive NEURO, Inc. Apparatus, system, and method for vasculature obstruction removal
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
CN113543732A (en) * 2019-01-08 2021-10-22 美国前进诺欧有限公司 Devices, systems, and methods for removing a vascular system obstruction
JP2022520573A (en) 2019-02-13 2022-03-31 エンボライン, インコーポレイテッド Catheter with integrated embolic protection device
WO2020180866A1 (en) * 2019-03-04 2020-09-10 Boston Scientific Scimed, Inc. Systems and methods for protecting the cerebral vasculature
ES2910600T3 (en) 2019-03-04 2022-05-12 Neuravi Ltd Powered Clot Recovery Catheter
US11369400B2 (en) 2019-03-20 2022-06-28 Covidien Lp Balloon dissector
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US11707351B2 (en) 2019-08-19 2023-07-25 Encompass Technologies, Inc. Embolic protection and access system
WO2021041831A1 (en) 2019-08-30 2021-03-04 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
JP2021041169A (en) 2019-09-11 2021-03-18 ニューラヴィ・リミテッド Expandable mouth catheter
AU2020368528A1 (en) 2019-10-16 2022-04-21 Inari Medical, Inc. Systems, devices, and methods for treating vascular occlusions
US11712231B2 (en) 2019-10-29 2023-08-01 Neuravi Limited Proximal locking assembly design for dual stent mechanical thrombectomy device
US11839725B2 (en) 2019-11-27 2023-12-12 Neuravi Limited Clot retrieval device with outer sheath and inner catheter
US11779364B2 (en) 2019-11-27 2023-10-10 Neuravi Limited Actuated expandable mouth thrombectomy catheter
US11517340B2 (en) * 2019-12-03 2022-12-06 Neuravi Limited Stentriever devices for removing an occlusive clot from a vessel and methods thereof
US11617865B2 (en) 2020-01-24 2023-04-04 Mivi Neuroscience, Inc. Suction catheter systems with designs allowing rapid clearing of clots
US11633198B2 (en) 2020-03-05 2023-04-25 Neuravi Limited Catheter proximal joint
US11903589B2 (en) 2020-03-24 2024-02-20 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
US11883043B2 (en) 2020-03-31 2024-01-30 DePuy Synthes Products, Inc. Catheter funnel extension
US11759217B2 (en) 2020-04-07 2023-09-19 Neuravi Limited Catheter tubular support
US11730501B2 (en) 2020-04-17 2023-08-22 Neuravi Limited Floating clot retrieval device for removing clots from a blood vessel
US11871946B2 (en) 2020-04-17 2024-01-16 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11717308B2 (en) 2020-04-17 2023-08-08 Neuravi Limited Clot retrieval device for removing heterogeneous clots from a blood vessel
US11737771B2 (en) 2020-06-18 2023-08-29 Neuravi Limited Dual channel thrombectomy device
US11395669B2 (en) 2020-06-23 2022-07-26 Neuravi Limited Clot retrieval device with flexible collapsible frame
US11439418B2 (en) 2020-06-23 2022-09-13 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11864781B2 (en) 2020-09-23 2024-01-09 Neuravi Limited Rotating frame thrombectomy device
US11786354B2 (en) * 2020-10-01 2023-10-17 Gil Vardi Embolic filter device
US11596771B2 (en) 2020-12-14 2023-03-07 Cardiac Dimensions Pty. Ltd. Modular pre-loaded medical implants and delivery systems
US20220202428A1 (en) * 2020-12-29 2022-06-30 Neuravi Limited Fibrin rich / soft clot mechanical thrombectomy device
US20220257269A1 (en) 2021-02-18 2022-08-18 Boston Scientific Scimed, Inc. Thrombectomy apparatuses and methods
US11471183B1 (en) * 2021-02-18 2022-10-18 Boston Scientific Scimed, Inc. Thrombectomy methods
US11872354B2 (en) 2021-02-24 2024-01-16 Neuravi Limited Flexible catheter shaft frame with seam
US20230051493A1 (en) * 2021-08-16 2023-02-16 Neuravi Limited Combination stentriever and microcatheter
WO2023028308A2 (en) * 2021-08-27 2023-03-02 Ganske Karl V Thrombectomy capture system
WO2023128892A1 (en) * 2021-12-28 2023-07-06 İsti̇nye Üni̇versi̇tesi̇ Lesion recovery apparatus
DE102022114767A1 (en) 2022-06-13 2023-12-14 Phenox Gmbh Endovascular device with guide wire

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US5423851A (en) * 1994-03-06 1995-06-13 Samuels; Shaun L. W. Method and apparatus for affixing an endoluminal device to the walls of tubular structures within the body
US5486183A (en) * 1990-10-09 1996-01-23 Raychem Corporation Device or apparatus for manipulating matter
US5769816A (en) * 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US5800525A (en) * 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5848964A (en) * 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use
US6001118A (en) * 1997-03-06 1999-12-14 Scimed Life Systems, Inc. Distal protection device and method
US6605102B1 (en) * 1994-07-08 2003-08-12 Ev3, Inc. Intravascular trap and method of trapping particles in bodily fluids

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US130685A (en) * 1872-08-20 Improvement in locomotive-engines
US3472230A (en) 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3592186A (en) * 1969-01-28 1971-07-13 Claude Oster Cytologic scraper
US3889657A (en) * 1974-02-12 1975-06-17 Gomco Surgical Mfg Co Uterine aspirating curette
US3952747A (en) * 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
SU764684A1 (en) * 1978-01-31 1980-09-25 Челябинский государственный медицинский институт Trap filter
US4221217A (en) * 1978-05-01 1980-09-09 Amezcua Saul O Nasal device
DE2821048C2 (en) 1978-05-13 1980-07-17 Willy Ruesch Gmbh & Co Kg, 7053 Kernen Medical instrument
US4425908A (en) * 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4447227A (en) * 1982-06-09 1984-05-08 Endoscopy Surgical Systems, Inc. Multi-purpose medical devices
US4643184A (en) * 1982-09-29 1987-02-17 Mobin Uddin Kazi Embolus trap
US5190546A (en) * 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US5104399A (en) * 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4590938A (en) * 1984-05-04 1986-05-27 Segura Joseph W Medical retriever device
DE3417738C2 (en) 1984-05-12 1986-10-02 Ing. Walter Hengst GmbH & Co KG, 4400 Münster Blood filter that can be used in veins
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4842579B1 (en) * 1984-05-14 1995-10-31 Surgical Systems & Instr Inc Atherectomy device
US4926858A (en) * 1984-05-30 1990-05-22 Devices For Vascular Intervention, Inc. Atherectomy device for severe occlusions
US4580568A (en) * 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4790813A (en) * 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4807626A (en) * 1985-02-14 1989-02-28 Mcgirr Douglas B Stone extractor and method
IT8535720V0 (en) 1985-03-27 1985-03-27 Ital Idee Srl AIR INTAKE FILTER CLOGGING INDICATOR, IN PARTICULAR FOR MOTOR VEHICLE ENGINES
FR2580504B1 (en) 1985-04-22 1987-07-10 Pieronne Alain FILTER FOR THE PARTIAL AND AT LEAST PROVISIONAL INTERRUPTION OF A VEIN AND CATHETER CARRYING THE FILTER
US4706671A (en) * 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
US4650466A (en) * 1985-11-01 1987-03-17 Angiobrade Partners Angioplasty device
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4790812A (en) * 1985-11-15 1988-12-13 Hawkins Jr Irvin F Apparatus and method for removing a target object from a body passsageway
US4794931A (en) * 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
US4728319A (en) * 1986-03-20 1988-03-01 Helmut Masch Intravascular catheter
US4723549A (en) * 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4762130A (en) * 1987-01-15 1988-08-09 Thomas J. Fogarty Catheter with corkscrew-like balloon
US4907336A (en) * 1987-03-13 1990-03-13 Cook Incorporated Method of making an endovascular stent and delivery system
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
JPS63238872A (en) 1987-03-25 1988-10-04 テルモ株式会社 Instrument for securing inner diameter of cavity of tubular organ and catheter equipped therewith
US4817600A (en) 1987-05-22 1989-04-04 Medi-Tech, Inc. Implantable filter
US4794928A (en) * 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US4898575A (en) * 1987-08-31 1990-02-06 Medinnovations, Inc. Guide wire following tunneling catheter system and method for transluminal arterial atherectomy
US4873978A (en) * 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
FR2624747A1 (en) * 1987-12-18 1989-06-23 Delsanti Gerard REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS
US4921478A (en) * 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
US5556376A (en) * 1988-07-22 1996-09-17 Yoon; Inbae Multifunctional devices having loop configured portions and collection systems for endoscopic surgical procedures and methods thereof
US4921484A (en) * 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5011488A (en) * 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US4986807A (en) * 1989-01-23 1991-01-22 Interventional Technologies, Inc. Atherectomy cutter with radially projecting blade
US5152777A (en) 1989-01-25 1992-10-06 Uresil Corporation Device and method for providing protection from emboli and preventing occulsion of blood vessels
US5087265A (en) * 1989-02-17 1992-02-11 American Biomed, Inc. Distal atherectomy catheter
FR2643250B1 (en) 1989-02-20 1997-12-26 Lg Medical Sa INTERVENTION DEVICE ON THE CARDIOVASCULAR SYSTEM ALLOWING IN PARTICULAR THE TREATMENT OF THROMBUS
US4969891A (en) 1989-03-06 1990-11-13 Gewertz Bruce L Removable vascular filter
US5632746A (en) * 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
DE8910603U1 (en) * 1989-09-06 1989-12-07 Guenther, Rolf W., Prof. Dr.
US5002560A (en) * 1989-09-08 1991-03-26 Advanced Cardiovascular Systems, Inc. Expandable cage catheter with a rotatable guide
DE8910856U1 (en) * 1989-09-12 1989-11-30 Schneider (Europe) Ag, Zuerich, Ch
US5100425A (en) * 1989-09-14 1992-03-31 Medintec R&D Limited Partnership Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses
DE4030998C2 (en) 1989-10-04 1995-11-23 Ernst Peter Prof Dr M Strecker Percutaneous vascular filter
AU6376190A (en) 1989-10-25 1991-05-02 C.R. Bard Inc. Occluding catheter and methods for treating cerebral arteries
US5019088A (en) * 1989-11-07 1991-05-28 Interventional Technologies Inc. Ovoid atherectomy cutter
US5085662A (en) * 1989-11-13 1992-02-04 Scimed Life Systems, Inc. Atherectomy catheter and related components
US5195955A (en) * 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
GB2238485B (en) * 1989-11-28 1993-07-14 Cook William Europ A collapsible filter for introduction in a blood vessel of a patient
US5421832A (en) * 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
FR2655533A1 (en) 1989-12-13 1991-06-14 Lefebvre Jean Marie FILTER CATHETER.
US5007917A (en) * 1990-03-08 1991-04-16 Stryker Corporation Single blade cutter for arthroscopic surgery
US5071407A (en) * 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5100424A (en) * 1990-05-21 1992-03-31 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
CA2048307C (en) * 1990-08-14 1998-08-18 Rolf Gunther Method and apparatus for filtering blood in a blood vessel of a patient
US5160342A (en) 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
DE4025825A1 (en) * 1990-08-16 1992-02-20 Cook William Europ DEVICE FOR CRUSHING BLOOD CLOTS
US5108419A (en) * 1990-08-16 1992-04-28 Evi Corporation Endovascular filter and method for use thereof
US5100423A (en) 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
FR2666980B1 (en) 1990-09-26 1993-07-23 Lg Medical BLOOD FILTRATION UNIT AND DEVICE FOR INTRODUCING SUCH A UNIT ONTO THE BLOOD PATH.
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
WO1992006734A1 (en) * 1990-10-18 1992-04-30 Ho Young Song Self-expanding endovascular stent
US5053008A (en) * 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5147379A (en) * 1990-11-26 1992-09-15 Louisiana State University And Agricultural And Mechanical College Insertion instrument for vena cava filter
US5695518A (en) * 1990-12-28 1997-12-09 Laerum; Frode Filtering device for preventing embolism and/or distension of blood vessel walls
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
WO1992014413A1 (en) * 1991-02-19 1992-09-03 Fischell Robert Improved apparatus and method for atherectomy
ES2127756T3 (en) * 1991-06-17 1999-05-01 Wilson Cook Medical Inc ENDOSCOPIC EXTRACTION DEVICE WITH A COMPOSITE METALLIC FILAR STRUCTURE.
US5527354A (en) * 1991-06-28 1996-06-18 Cook Incorporated Stent formed of half-round wire
US5314472A (en) * 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5415630A (en) * 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
US5176688A (en) * 1991-07-17 1993-01-05 Perinchery Narayan Stone extractor and method
DE9109006U1 (en) 1991-07-22 1991-10-10 Schmitz-Rode, Thomas, Dipl.-Ing. Dr.Med., 5100 Aachen, De
US5387235A (en) * 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
FR2683449A1 (en) * 1991-11-08 1993-05-14 Cardon Alain ENDOPROTHESIS FOR TRANSLUMINAL IMPLANTATION.
US5395349A (en) * 1991-12-13 1995-03-07 Endovascular Technologies, Inc. Dual valve reinforced sheath and method
FR2685190B1 (en) * 1991-12-23 1998-08-07 Jean Marie Lefebvre ROTARY ATHERECTOMY OR THROMBECTOMY DEVICE WITH CENTRIFUGAL TRANSVERSE DEVELOPMENT.
US5626605A (en) * 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
US5507767A (en) * 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
CA2087132A1 (en) * 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5405377A (en) * 1992-02-21 1995-04-11 Endotech Ltd. Intraluminal stent
US5224953A (en) * 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
FR2694687B1 (en) 1992-08-12 1994-09-30 Celsa Lg Vascular prosthesis for filtering blood in a vessel and interventional device for such temporary filtering.
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5643297A (en) * 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5792157A (en) 1992-11-13 1998-08-11 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5383926A (en) * 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
US5318576A (en) * 1992-12-16 1994-06-07 Plassche Jr Walter M Endovascular surgery systems
FR2699809B1 (en) * 1992-12-28 1995-02-17 Celsa Lg Device which can selectively constitute a temporary blood filter.
US5354310A (en) * 1993-03-22 1994-10-11 Cordis Corporation Expandable temporary graft
US5897567A (en) * 1993-04-29 1999-04-27 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
CA2161640C (en) * 1993-04-29 2005-04-12 Thomas V. Ressemann Expandable intravascular occlusion material removal device
US5456667A (en) 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
FR2706806A1 (en) * 1993-06-25 1994-12-30 Michelin & Cie
US5425765A (en) * 1993-06-25 1995-06-20 Tiefenbrun; Jonathan Surgical bypass method
US5419774A (en) * 1993-07-13 1995-05-30 Scimed Life Systems, Inc. Thrombus extraction device
US5462529A (en) 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5634897A (en) * 1993-10-08 1997-06-03 Lake Region Manufacturing, Inc. Rheolytic occlusion removal catheter system and method
FR2713081B1 (en) 1993-11-29 1996-01-12 Celsa Lg Improved blood filter with two series of petal legs.
US5522819A (en) * 1994-05-12 1996-06-04 Target Therapeutics, Inc. Dual coil medical retrieval device
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
DE29522101U1 (en) 1994-06-08 1999-12-09 Cardiovascular Concepts Inc Endoluminal prosthesis
DE9409484U1 (en) * 1994-06-11 1994-08-04 Naderlinger Eduard Vena cava thrombus filter
EP0954244A1 (en) * 1994-07-01 1999-11-10 SciMed Life Systems, Inc. Intravascular device utilizing fluid to extract occlusive material
US5512044A (en) * 1994-10-11 1996-04-30 Duer; Edward Y. Embolic cutting catheter
FR2726993B1 (en) * 1994-11-18 1997-04-25 Sgro Jean Claude SINGLE-USE INFLATABLE DEVICE FOR SPREADING ANATOMIC TISSUES ESPECIALLY IN COELIOSCOPIC SURGERY AND ITS APPLICATION EQUIPMENT
US5658296A (en) 1994-11-21 1997-08-19 Boston Scientific Corporation Method for making surgical retrieval baskets
US5709704A (en) * 1994-11-30 1998-01-20 Boston Scientific Corporation Blood clot filtering
US5549626A (en) * 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
DE19501450A1 (en) * 1995-01-19 1996-07-25 Basf Ag Thermoplastic polyamide molding compounds
US5509227A (en) * 1995-03-22 1996-04-23 Marrero; Orestes Fishing net mechanism
EP0819014B1 (en) * 1995-03-30 2003-02-05 Heartport, Inc. Endovascular cardiac venting catheter
NL1000105C2 (en) * 1995-04-10 1996-10-11 Cordis Europ Catheter with filter and thrombi draining device.
US5795322A (en) 1995-04-10 1998-08-18 Cordis Corporation Catheter with filter and thrombus-discharge device
NL1001410C2 (en) 1995-05-19 1996-11-20 Cordis Europ Medical device for long-term residence in a body.
US5833650A (en) 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
US6280413B1 (en) 1995-06-07 2001-08-28 Medtronic Ave, Inc. Thrombolytic filtration and drug delivery catheter with a self-expanding portion
FR2737653B1 (en) 1995-08-10 1997-09-19 Braun Celsa Sa DEFINITIVE FILTER COMPRISING AN ORIFICE FOR THE PASSAGE OF MEDICAL DEVICES AND ITS MANUFACTURING METHOD
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US6264663B1 (en) 1995-10-06 2001-07-24 Metamorphic Surgical Devices, Llc Device for removing solid objects from body canals, cavities and organs including an invertable basket
US5779716A (en) 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
US5989281A (en) 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5749848A (en) * 1995-11-13 1998-05-12 Cardiovascular Imaging Systems, Inc. Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment
US5695519A (en) * 1995-11-30 1997-12-09 American Biomed, Inc. Percutaneous filter for carotid angioplasty
US5728066A (en) * 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
US5827429A (en) 1996-01-18 1998-10-27 Filtertek Inc. Intravenous filter device
NL1002423C2 (en) 1996-02-22 1997-08-25 Cordis Europ Temporary filter catheter.
US5935139A (en) 1996-05-03 1999-08-10 Boston Scientific Corporation System for immobilizing or manipulating an object in a tract
EP0897288A4 (en) 1996-05-14 2000-04-05 Embol X Inc Aortic occluder with associated filter and methods of use during cardiac surgery
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
GB2313610B (en) * 1996-05-29 2000-04-26 Baker Hughes Inc Method of performing a downhole operation
US5662671A (en) * 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US6066158A (en) 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
US5893867A (en) * 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
US5876367A (en) * 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
FR2758078B1 (en) 1997-01-03 1999-07-16 Braun Celsa Sa BLOOD FILTER WITH IMPROVED PERMEABILITY
EP1226796B1 (en) * 1997-02-03 2005-06-01 Angioguard, Inc. Vascular filter
US5882329A (en) 1997-02-12 1999-03-16 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
US5800457A (en) 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
US5827324A (en) 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
US6152946A (en) 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US5906618A (en) * 1997-03-20 1999-05-25 Vanderbilt University Microcatheter with auxiliary parachute guide structure
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5911734A (en) * 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5846260A (en) 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US5954745A (en) 1997-05-16 1999-09-21 Gertler; Jonathan Catheter-filter set having a compliant seal
US6059814A (en) * 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US5947995A (en) 1997-06-06 1999-09-07 Samuels; Shaun Lawrence Wilkie Method and apparatus for removing blood clots and other objects
US5904698A (en) * 1997-06-10 1999-05-18 Applied Medical Resources Corporation Surgical shaving device for use within body conduits
US6245088B1 (en) 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
US5941896A (en) 1997-09-08 1999-08-24 Montefiore Hospital And Medical Center Filter and method for trapping emboli during endovascular procedures
FR2768326B1 (en) 1997-09-18 1999-10-22 De Bearn Olivier Despalle TEMPORARY BLOOD FILTER
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US5908435A (en) * 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
US6013085A (en) * 1997-11-07 2000-01-11 Howard; John Method for treating stenosis of the carotid artery
DE69839888D1 (en) 1997-11-12 2008-09-25 Genesis Technologies Llc DEVICE FOR REMOVING OCCLUSIONS IN BIOLOGICAL PASSES
US5989210A (en) 1998-02-06 1999-11-23 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
EP1054634A4 (en) 1998-02-10 2006-03-29 Artemis Medical Inc Entrapping apparatus and method for use
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6206868B1 (en) 1998-03-13 2001-03-27 Arteria Medical Science, Inc. Protective device and method against embolization during treatment of carotid artery disease
US6007557A (en) 1998-04-29 1999-12-28 Embol-X, Inc. Adjustable blood filtration system
US6051014A (en) * 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6172987B1 (en) * 1998-11-10 2001-01-09 Nortel Networks Limited Switching compression routines with no loss of data
US6179561B1 (en) * 1998-12-02 2001-01-30 Sunonwealth Electric Machine Industry Co., Ltd. Fan wheel structures
US6171327B1 (en) * 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
US6277138B1 (en) 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
DE19916162A1 (en) 1999-04-11 2000-10-26 Oralia Gmbh Modular dental laser system; has laser unit with soft or hard laser, transfer unit to transmit laser beam to applicator and operation element to control laser unit, along with optional modules
US6068645A (en) * 1999-06-07 2000-05-30 Tu; Hosheng Filter system and methods for removing blood clots and biological material
US6179859B1 (en) * 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6203561B1 (en) * 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US6179861B1 (en) 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
US6530939B1 (en) 1999-07-30 2003-03-11 Incept, Llc Vascular device having articulation region and methods of use
US6214026B1 (en) * 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
US6142987A (en) 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6245087B1 (en) 1999-08-03 2001-06-12 Embol-X, Inc. Variable expansion frame system for deploying medical devices and methods of use
US6234044B1 (en) * 1999-08-04 2001-05-22 Daimlerchrysler Corporation Gear shift lever boot cover
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US6168579B1 (en) * 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6264672B1 (en) 1999-10-25 2001-07-24 Biopsy Sciences, Llc Emboli capturing device
US6171328B1 (en) 1999-11-09 2001-01-09 Embol-X, Inc. Intravascular catheter filter with interlocking petal design and methods of use
US6290710B1 (en) 1999-12-29 2001-09-18 Advanced Cardiovascular Systems, Inc. Embolic protection device

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US5486183A (en) * 1990-10-09 1996-01-23 Raychem Corporation Device or apparatus for manipulating matter
US5423851A (en) * 1994-03-06 1995-06-13 Samuels; Shaun L. W. Method and apparatus for affixing an endoluminal device to the walls of tubular structures within the body
US6605102B1 (en) * 1994-07-08 2003-08-12 Ev3, Inc. Intravascular trap and method of trapping particles in bodily fluids
US5769816A (en) * 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US6001118A (en) * 1997-03-06 1999-12-14 Scimed Life Systems, Inc. Distal protection device and method
US20030130685A1 (en) * 1997-03-06 2003-07-10 Scimed Life Systems, Inc. Distal protection device and method
US5800525A (en) * 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5848964A (en) * 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use

Cited By (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8057504B2 (en) 1997-11-07 2011-11-15 Salviac Limited Embolic protection device
US8430901B2 (en) 1997-11-07 2013-04-30 Salviac Limited Embolic protection device
US8221448B2 (en) 1997-11-07 2012-07-17 Salviac Limited Embolic protection device
US8226678B2 (en) 1997-11-07 2012-07-24 Salviac Limited Embolic protection device
US8241319B2 (en) 1997-11-07 2012-08-14 Salviac Limited Embolic protection system
US8123776B2 (en) 1997-11-07 2012-02-28 Salviac Limited Embolic protection system
US7662165B2 (en) 1997-11-07 2010-02-16 Salviac Limited Embolic protection device
US20070162070A1 (en) * 1997-11-07 2007-07-12 Salviac Limited Embolic protection device
US8052716B2 (en) 1997-11-07 2011-11-08 Salviac Limited Embolic protection system
US8852226B2 (en) 1997-11-07 2014-10-07 Salviac Limited Vascular device for use during an interventional procedure
US7780697B2 (en) 1997-11-07 2010-08-24 Salviac Limited Embolic protection system
US7972352B2 (en) 1997-11-07 2011-07-05 Salviac Limited Embolic protection system
US7785342B2 (en) 1997-11-07 2010-08-31 Salviac Limited Embolic protection device
US8216270B2 (en) 1997-11-07 2012-07-10 Salviac Limited Embolic protection device
US8328842B2 (en) 1997-11-07 2012-12-11 Salviac Limited Filter element with retractable guidewire tip
US7833242B2 (en) 1997-11-07 2010-11-16 Salviac Limited Embolic protection device
US7837701B2 (en) 1997-11-07 2010-11-23 Salviac Limited Embolic protection device
US7842063B2 (en) 1997-11-07 2010-11-30 Salviac Limited Embolic protection device
US7901426B2 (en) 1997-11-07 2011-03-08 Salviac Limited Embolic protection device
US7842066B2 (en) 1997-11-07 2010-11-30 Salviac Limited Embolic protection system
US7846176B2 (en) 1997-11-07 2010-12-07 Salviac Limited Embolic protection system
US7901427B2 (en) 1997-11-07 2011-03-08 Salviac Limited Filter element with retractable guidewire tip
US8603131B2 (en) 1997-11-07 2013-12-10 Salviac Limited Embolic protection device
US7799051B2 (en) 1999-05-07 2010-09-21 Salviac Limited Support frame for an embolic protection device
US8002790B2 (en) 1999-05-07 2011-08-23 Salviac Limited Support frame for an embolic protection device
US7780694B2 (en) 1999-12-23 2010-08-24 Advanced Cardiovascular Systems, Inc. Intravascular device and system
US8142442B2 (en) 1999-12-23 2012-03-27 Abbott Laboratories Snare
US8137377B2 (en) 1999-12-23 2012-03-20 Abbott Laboratories Embolic basket
US8845583B2 (en) 1999-12-30 2014-09-30 Abbott Cardiovascular Systems Inc. Embolic protection devices
US7918820B2 (en) 1999-12-30 2011-04-05 Advanced Cardiovascular Systems, Inc. Device for, and method of, blocking emboli in vessels such as blood arteries
US8177791B2 (en) 2000-07-13 2012-05-15 Abbott Cardiovascular Systems Inc. Embolic protection guide wire
US7931666B2 (en) 2000-12-19 2011-04-26 Advanced Cardiovascular Systems, Inc. Sheathless embolic protection system
US7959646B2 (en) 2001-06-29 2011-06-14 Abbott Cardiovascular Systems Inc. Filter device for embolic protection systems
US8016854B2 (en) 2001-06-29 2011-09-13 Abbott Cardiovascular Systems Inc. Variable thickness embolic filtering devices and methods of manufacturing the same
US7959647B2 (en) 2001-08-30 2011-06-14 Abbott Cardiovascular Systems Inc. Self furling umbrella frame for carotid filter
US7842064B2 (en) 2001-08-31 2010-11-30 Advanced Cardiovascular Systems, Inc. Hinged short cage for an embolic protection device
US8262689B2 (en) 2001-09-28 2012-09-11 Advanced Cardiovascular Systems, Inc. Embolic filtering devices
US7927349B2 (en) 2001-12-21 2011-04-19 Salviac Limited Support frame for an embolic protection device
US7972356B2 (en) 2001-12-21 2011-07-05 Abbott Cardiovascular Systems, Inc. Flexible and conformable embolic filtering devices
US8114115B2 (en) 2001-12-21 2012-02-14 Salviac Limited Support frame for an embolic protection device
US20060287671A1 (en) * 2002-09-04 2006-12-21 Boston Scientific Scimed, Inc. Sheath tip
US7815660B2 (en) 2002-09-30 2010-10-19 Advanced Cardivascular Systems, Inc. Guide wire with embolic filtering attachment
US7976560B2 (en) 2002-09-30 2011-07-12 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US8029530B2 (en) 2002-09-30 2011-10-04 Abbott Cardiovascular Systems Inc. Guide wire with embolic filtering attachment
US8591540B2 (en) 2003-02-27 2013-11-26 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US9820845B2 (en) 2003-03-28 2017-11-21 Covidien Lp Holding zone for intravascular medical device
US10660737B2 (en) 2003-03-28 2020-05-26 Covidien Lp Double ended intravascular medical device
US7892251B1 (en) 2003-11-12 2011-02-22 Advanced Cardiovascular Systems, Inc. Component for delivering and locking a medical device to a guide wire
EP1987787A1 (en) * 2004-02-19 2008-11-05 Applied Medical Resources Corporation Embolectomy capture sheath
WO2005079678A1 (en) * 2004-02-19 2005-09-01 Applied Medical Resources Corporation Embolectomy capture sheath
US20050187570A1 (en) * 2004-02-19 2005-08-25 Applied Medical Resources Corporation Embolectomy capture sheath
US8308753B2 (en) 2004-03-19 2012-11-13 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US7879065B2 (en) 2004-03-19 2011-02-01 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US7678129B1 (en) 2004-03-19 2010-03-16 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US20060223386A1 (en) * 2005-03-15 2006-10-05 Dharmendra Pal Embolic protection device
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US9259305B2 (en) 2005-03-31 2016-02-16 Abbott Cardiovascular Systems Inc. Guide wire locking mechanism for rapid exchange and other catheter systems
US8845677B2 (en) 2005-06-20 2014-09-30 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7867247B2 (en) 2005-07-12 2011-01-11 Cook Incorporated Methods for embolic protection during treatment of a stenotic lesion in a body vessel
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US9907639B2 (en) 2006-09-19 2018-03-06 Cook Medical Technologies Llc Apparatus and methods for in situ embolic protection
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US7867273B2 (en) 2007-06-27 2011-01-11 Abbott Laboratories Endoprostheses for peripheral arteries and other body vessels
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US9398946B2 (en) 2007-09-14 2016-07-26 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US8657849B2 (en) 2008-12-29 2014-02-25 Cook Medical Technologies Llc Embolic protection device and method of use

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US6872216B2 (en) 2005-03-29
DE69841933D1 (en) 2010-11-18
US6245089B1 (en) 2001-06-12
EP0923344A4 (en) 2003-07-23
EP1905365A1 (en) 2008-04-02
DE69828946T2 (en) 2006-05-11
US20050119691A1 (en) 2005-06-02
DE69838800T2 (en) 2008-04-30
EP1510177B1 (en) 2007-11-28
US6663652B2 (en) 2003-12-16
DE69838800D1 (en) 2008-01-10
EP0923344A1 (en) 1999-06-23
US20050101986A1 (en) 2005-05-12
WO1998038920A1 (en) 1998-09-11
ATE288704T1 (en) 2005-02-15
US5814064A (en) 1998-09-29
ATE483411T1 (en) 2010-10-15
EP0923344B1 (en) 2005-02-09
US6053932A (en) 2000-04-25
US20030130687A1 (en) 2003-07-10
US20030130685A1 (en) 2003-07-10
EP1510177A1 (en) 2005-03-02
US20040106944A1 (en) 2004-06-03
US20030130688A1 (en) 2003-07-10
EP1905365B1 (en) 2010-10-06
DE69828946D1 (en) 2005-03-17
US20010044632A1 (en) 2001-11-22
DE29824749U1 (en) 2002-10-10
US20030083693A1 (en) 2003-05-01
US6001118A (en) 1999-12-14

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