US20010047135A1 - Diagnosing and performing interventional procedures on tissue in vivo - Google Patents
Diagnosing and performing interventional procedures on tissue in vivo Download PDFInfo
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- US20010047135A1 US20010047135A1 US09/928,146 US92814601A US2001047135A1 US 20010047135 A1 US20010047135 A1 US 20010047135A1 US 92814601 A US92814601 A US 92814601A US 2001047135 A1 US2001047135 A1 US 2001047135A1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A61B2017/22077—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other the instrument being only slidable in a channel, e.g. advancing optical fibre through a channel with a part piercing the tissue
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Abstract
A catheter for diagnosing and performing an interventional procedure on tissue has an elongated catheter shaft, and optical fibers, extending through the catheter shaft, for transmitting light to tissue located at a distal end of the catheter and conveying light back from the tissue for analysis by a spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue. An interventional device is located at the distal end of the catheter for engaging tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue. An assembly for imaging and performing an interventional procedure on tissue has an endoscope in combination with an endoscopically insertable catheter having an ultrasound imaging device for imaging a tissue structure located at a distal end of the endoscope so as to enable the depth of penetration of the tissue structure to be displayed, and an endoscopically insertable interventional device for engaging the tissue structure imaged by the ultrasound imaging device.
Description
- This application relates to diagnosing and performing interventional procedures on tissue using endoscopically insertable catheters.
- Lesions in body lumens such as the alimentary track may be diagnosed by inserting an endoscope into the alimentary track and inserting through a working channel of the endoscope a catheter having optical fibers for transmitting light to tissue located at a distal end of the catheter and for conveying light back from the tissue for analysis by a spectroscopic diagnosis system. If the spectroscopic diagnosis system determines an interventional procedure should be performed on the tissue, a biopsy of the tissue may be taken or the tissue may be otherwise removed or treated.
- One aspect of the invention features a catheter for diagnosing and performing an interventional procedure on tissue. The catheter has an elongated catheter shaft, and optical fibers, extending through the catheter shaft, transmit light to tissue located at a distal end of the catheter shaft and convey light back from the tissue for analysis by a spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue. An interventional device is located at the distal end of the catheter shaft for engaging tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue.
- In various embodiments the catheter is constructed to be inserted through the working channel of an endoscope, and the interventional device is, for example, a scalpel, forceps jaws, a snare, a scissors, or a needle. An interventional needle can be used, for example, to cut the tissue, to apply an adhesive material to the tissue, to inject a chemical ablation fluid into the tissue, or to inject a marking fluid into the tissue so as to enable the tissue to be treated by another interventional device, which may be located on another catheter. Because the interventional device is located on the same catheter as the optical fibers, the physician can perform the interventional procedure on the tissue without having to remove the catheter from the patient's body. Moreover, the diagnosis and interventional procedure can be accomplished at multiple sites without having to remove the catheter from the patient's body. In various embodiments the interventional device is, for example, a scalpel, forceps jaws, a snare, a scissors, or a needle.
- Another aspect of the invention features an assembly comprising an endoscope, a catheter shaft insertable through a working channel of the endoscope having optical fibers for transmitting light to tissue and from tissue for analysis by a spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue, and an interventional device, insertable through a working channel of the endoscope, for performing the interventional procedure on the tissue.
- Another aspect of the invention features a method for imaging and performing an interventional procedure on tissue. A catheter having an ultrasound imaging device located at its distal end is inserted through a working channel of an endoscope, for imaging a tissue structure located at a distal end of the endoscope, and the tissue structure is displayed in a manner that indicates-the depth of penetration of the tissue structure into the body of the living being. An interventional device, which is inserted through a working channel of the endoscope, performs interventional therapy on the tissue structure in a manner responsive to the displayed depth of penetration of the tissue structure.
- This aspect of the invention enables the physician to determine the depth to which a tumor has grown into or through the wall of a lumen in order to determine whether the tumor can be removed safely from the lumen. The physician can rely on the ultrasound image display to determine how much tissue to remove in view of the depth of penetration of the tissue structure, and can also observe the ultrasound image of the tissue structure while performing the interventional procedure on the tissue structure so as to ensure that an appropriate amount of tissue is removed.
- In general, the invention aids physicians in the accurate early diagnosis of patients with cancer or other abnormalities inside the body. Many cancers or other abnormalities can be treated efficiently if diagnosed and treated early enough in the least invasive manner. The invention helps physicians to locate suspect areas, diagnose accurately, and sample and treat tissue efficiently. The invention also provides high diagnostic accuracy and short procedural time by providing accurate data and avoiding unnecessary biopsies. Consequently, overall health care costs are low because of low lab analysis costs and minimal outpatient hospital visits.
- Numerous other features, objects, and advantages of the invention will become apparent from the following detailed description when read in connection with the accompanying drawings.
- FIGS.1-6 are a set of drawings showing the steps of a process for spectroscopically diagnosing and marking tissue using an endoscopically insertable catheter and for removing tissue using another endoscopically insertable catheter.
- FIG. 7 is a drawing of an endoscopically insertable catheter combining optical fibers and forceps jaws.
- FIG. 8. is a drawing of an endoscopically insertable catheter combining optical fibers and a polypectomy snare.
- FIG. 9 is a drawing of an endoscopically insertable catheter combining optical fibers and scissors.
- FIG. 10 is a drawing of an endoscopically insertable catheter combining optical fibers and a needle.
- FIG. 11 is a drawing of an endoscope in combination with an endoscopically insertable catheter having forceps jaws and an endoscopically insertable catheter having an ultrasound imaging device.
- FIG. 12 is a drawing of an endoscope in combination with an endoscopically insertable catheter having optical fibers and forceps jaws and an endoscopically insertable catheter having an ultrasound imaging device.
- FIGS.1-6 refer to an endoscopically insertable catheter having optical fibers for transmitting light to tissue and for conveying light back from tissue for analysis by a spectroscopic diagnosis system and having a needle for performing an interventional procedure on the tissue, namely, injecting india ink into tissue diagnosed by the spectroscopic diagnosis system in order to mark the tissue for biopsy, treatment, or removal by another interventional device. If the spectroscopic diagnosis system determines that the tissue should be treated, the catheter having the optical fibers and needle is withdrawn from the endoscope and a catheter having forceps jaws is inserted through the endoscope in order to obtain a biopsy of the tissue or to remove or treat the tissue.
- With reference to FIG. 1, a distal end of an
endoscope 20 is inserted through alumen 21 of a patient's body, such as the esophagus, rectum or pulmonary tract.Endoscope 20 has anoptical fiber 22 connected to alight source 24 located at a proximal end ofendoscope 20 for transmitting light to tissue located at the distal end ofendoscope 20, anoptical fiber 26 connected to aneyepiece 28 located at the proximal end ofendoscope 20 for viewing the tissue, afluid channel 30 connected to afluid source 32 located at the proximal end ofendoscope 20 for flushing the tissue with fluid such as a wash for the visual fiber optics, and a workingchannel 34 for receiving a catheter. In FIG. 1,light source 24 is turned on. - With reference to FIG. 2, a
catheter 36 having an elongated catheter shaft is inserted through workingchannel 34 ofendoscope 20.Catheter 36 hasoptical fibers spectroscopic diagnosis system 42 located at the proximal end ofendoscope 20.Optical fibers Catheter 36 is connected to acatheter control mechanism 39 located at the proximal end ofendoscope 20 that controls the longitudinal movement ofcatheter 36 within workingchannel 34.Catheter control mechanism 39 also controls the longitudinal movement ofoptical fibers optical fibers catheter 36. In FIG. 2,light source 24 is turned on andoptical fibers catheter 36 to the tissue. - With reference to FIG. 3,
light source 24 is turned off,optical fiber 38 transmits light to the tissue, andoptical fiber 40 conveys light back from the tissue for analysis byspectroscopic diagnosis system 42 to determine whether the tissue should be treated. - For example,
optical fiber 38 transmits a monochromatic light beam having a wavelength or set of wavelengths selected to cause the tissue to fluoresce in a manner such that at one wavelength of the fluorescent light the intensity is approximately the same regardless of whether the tissue is normal or cancerous and at another wavelength of the fluorescent light the intensity differs substantially depending on whether the tissue is normal or cancerous. By analyzing the ratio of the intensity of the fluorescent light at the wavelength at which the intensity is approximately the same regardless of whether the tissue is normal or cancerous to the intensity of the fluorescent light at the wavelength at which the intensity differs substantially depending whether the tissue is normal or cancerous,spectroscopic diagnosis system 42 can determine whether the tissue is normal or cancerous, and in some instances whether the tissue is a benign tumor. The tissue may first be treated by a diagnostic reagent that bonds more selectively with diseased (cancerous) tissue than with normal tissue, or vice versa, and that absorbs light transmitted through the catheter and thereby causes the tissue to fluoresce at a wavelength or set of wavelengths different from the transmission wavelength. The intensity of the light conveyed back to the spectroscopic diagnosis system may be displayed graphically through the aid of a computer as a function of wavelength, and the endoscopist can interpret the data. - Referring to FIG. 4, if
spectroscopic diagnosis system 42 determines that the tissue should be treated,catheter control mechanism 39 retractsoptical fibers catheter 36, andlight source 24 is turned on.Catheter control mechanism 39 also controls the longitudinal movement of aneedle 44 which is located at the distal end ofcatheter 36 and extendsneedle 44 to the tissue.Needle 44, which can be made of SST or a suitable semi-rigid polymer that is non-reactive to diagnostic reagents, extends through alumen 46 in the catheter shaft.Needle 44 andoptical fibers Catheter control mechanism 39 causes indiaink 48 fromink reservoir 54 to be injected throughneedle 44 into the tissue to be treated. -
Optical fiber 38 transmits light to the tissue at a number of points andoptical fiber 40 conveys light back from the tissue for analysis byspectroscopic diagnosis system 42 in order to determine whether the tissue is cancerous at each of these points. Each such point that is determined to be cancerous is marked by indiaink 48 usingneedle 44. - With reference to FIG. 5,
light source 24 is turned on, andcatheter 36 havingoptical fibers needle 44 is withdrawn from workingchannel 34, and acatheter 50 havingforceps jaws 52 located at its distal end is inserted through workingchannel 34.Forceps jaws 52 are used to remove the tissue diagnosed by thespectroscopic diagnosis system 42 and marked by indiaink 48. - Numerous other embodiments are also within the scope of the claims. For example, FIGS.6-10 are drawings of different embodiments of an endoscopically
insertable catheter 100 combining optical fibers and various other types of interventional devices.Catheter 100 can be inserted in an endoscope as shown in FIGS. 1-5 in order to perform spectroscopic diagnosis on tissue and remove cancerous tissue without having to mark the cancerous tissue with india ink. After the interventional device removes the cancerous tissue, the optical fibers are used to perform spectroscopic diagnosis on the remaining tissue to determine whether all of the cancerous tissue has been removed. - In FIG. 6,
catheter 100 hasoptical fibers scalpel 106. - In FIG. 7,
catheter 100 hasoptical fibers forceps jaws 108, which may be multiple sampling biopsy forceps jaws capable of removing multiple samples of tissue into the body ofcatheter 100 as described in U.S. patent application Ser. No. 08/193,382, the entire disclosure of which is hereby incorporated herein by reference. The forceps jaws are caused to open up as shown in FIG. 7 by the withdrawal of an outer sleeve of the catheter (not shown) in the proximal direction and are caused to close together by pushing the outer sleeve in the distal direction. There is a hole at the tip of the forceps jaws through which the optical fibers can extend, the optical fibers being extendable and retractable with respect to the catheter and with respect to the forceps jaws. The forceps jaws can be used to remove tissue known to be unhealthy or to obtain biopsy samples for additional, cellular analysis. The optical fibers are of course retracted when the forceps jaws are being used. If the forceps jaws are of the multiple-biopsy type, the optical fibers can be bundled together as a single probe designed to spear through the biopsy samples within the catheter for continued diagnosis at additional sites. - Referring to FIG. 8,
catheter 100 hasoptical fibers polypectomy snare 110, which can be looped around a polyp and quickly retracted intocatheter 100 to excise the polyp. The optical fibers may alternatively pass through the same lumen as the snare. - Referring to FIG. 9,
catheter 100 hasoptical fibers scissors 112. Alternatively, the optical fibers may be glued to one of the scissors blades. - In FIG. 10,
catheter 100 hasoptical fibers needle 114, similar in construction toneedle 44 described above in connection with FIGS. 1-5.Needle 114 may be constructed to inject chemical ablation fluid or other drugs into tissue, possibly including time-release capsules containing cancer-fighting substances, to cut tissue, or to apply glue for temporarily adhering tissue between the esophagus and the stomach for treating gastroesophageal reflux disease. Localized chemical ablation or drug treatment can be performed at high concentration because of the specificity with which spectroscopic diagnosis can identify the location of unhealthy tissue.Needle 114 of FIG. 10 orneedle 44 of FIGS. 1-5 can also be used to inject a diagnostic reagent into a suspect site that bonds more selectively with diseased (cancerous) tissue than with normal tissue, or vice versa, as described above. Such a needle for injection of a diagnostic reagent can also be included in any of the catheters of FIGS. 6-9. In each of the embodiments of FIGS. 6-10,optical fibers catheter 100, and with the exception of the embodiment of FIG. 6, in which the optical fibers are glued toscalpel 106, any movement capabilities ofoptical fibers - Each of the embodiments described above in connection with FIGS.1-10 can be modified by eliminating the endoscope and adding additional optical fibers to the catheter for use in connection with the imaging function, or by using one or more optical fibers of the catheter not only in connection with the spectroscopic diagnosis function but also in connection with the imaging function. Since the catheter would be used without an endoscope, the catheter would have a steerable tip to allow movement and positioning of the catheter. The lumen of the catheter needle, in embodiments having such a needle, can double as a wash for the visual fiber optics as well as a vacuum and air source. One advantage of such a construction is that the catheter would not have to be as large as an endoscope combined with a catheter, because no endoscope working channel is required.
- With reference to FIG. 11, an
endoscope 200 is combined with an endoscopicallyinsertable catheter 216 havingforceps jaws 218 and an endoscopicallyinsertable catheter 212 having a rotatableultrasound imaging transducer 214.Ultrasound imaging transducer 214 provides a visual image of the tumor, which can be useful in determining the depth to which a tumor has grown into or through the wall of a lumen in order to determine whether the tumor can be removed safely from the lumen. If the tissue structure imaged byultrasound imaging transducer 214 can be removed safely from the lumen,forceps jaws 218 are used to remove the tissue structure. The visual image can also be used to determine how much tissue should be removed. The imaging can be performed simultaneously with the tissue removal, so as to enable the physician to see whether the tissue structure has been completely removed. -
Endoscope 200 has anoptical fiber 202 for transmitting light fromlight source 230 to tissue located at a distal end ofendoscope 200, anoptical fiber 204 for conveying light back from the tissue to eyepiece 234 for viewing tissue, afluid channel 206 for flushing tissue with fluid provided byfluid source 232, and workingchannels catheters catheter control mechanism 224 controls the longitudinal movement ofcatheter 216 within workingchannel 210 as well as the operation offorceps jaws 218. - Similarly, ultrasound
catheter control mechanism 226 controls the longitudinal movement ofultrasound catheter 212 within workingchannel 208 as well as the operation ofultrasound transducer 214, including its rotation, transmission of ultrasound pulses, and detection of reflected pulses by the transducer. The ultrasound image of the tissue imaged by the ultrasound transducer is displayed byultrasound image display 228. - The endoscope of FIG. 11 also may be used in combination with any of the different endoscopically insertable catheters combining optical fibers and interventional devices described above and shown in FIGS.610, which may be substituted for
interventional catheter 216. - For example, in FIG. 12,
catheter 216 hasforceps jaws 218 andoptical fibers spectroscopic diagnosis system 236 that spectroscopically diagnoses the tissue to determine whether the tissue should be treated, as is described above in connection with FIG. 7. - If the tissue is found to be cancerous or otherwise in need of removal,
ultrasound imaging catheter 214 is used to measure the depth to which a tumor has grown into or through the wall of a lumen to determine whether the tumor can be removed safely from the lumen. If the cancerous tissue imaged byultrasound imaging device 214 can be removed safely from the lumen,forceps jaws 218 are used to remove the cancerous tissue. Afterforceps jaws 218 remove the cancerous tissue,optical fibers - There have been described novel and improved apparatus and techniques for diagnosing and performing interventional procedures on tissue. It is evident that those skilled in the art may now make numerous uses and modifications of and departures from the specific embodiments described herein without departing from the inventive concept. For example, other interventional devices may be substituted for the ones described above and set forth in the drawings.
Claims (51)
1. A catheter, comprising: an elongated catheter shaft; an optical fiber, extending through the catheter shaft, for transmitting light to tissue located at a distal end of the catheter shaft; an optical fiber, extending through the catheter shaft, for conveying light back from the tissue for analysis by a spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue; and an interventional device located at the distal end of the catheter shaft for engaging tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue.
2. The catheter of , wherein the optical fiber for transmitting light to tissue is distinct from the optical fiber for conveying light back from the tissue.
claim 1
3. The catheter of , wherein the interventional device comprises a scalpel.
claim 1
4. The catheter of , wherein the interventional device comprises forceps jaws.
claim 1
5. The catheter of , wherein the interventional device comprises a snare.
claim 1
6. The catheter of , wherein the interventional device comprises a scissors.
claim 1
7. The catheter of , wherein the interventional device comprises a needle.
claim 1
8. The catheter of , wherein the needle is constructed to inject a marking fluid into the tissue.
claim 7
9. The catheter of , wherein the needle is constructed to inject a chemical ablation fluid into the tissue.
claim 7
10. The catheter of , wherein the needle is constructed to cut the tissue.
claim 7
11. The catheter of , wherein the needle is constructed to apply an adhesive material to the tissue.
claim 7
12. The catheter of , wherein the needle is constructed to convey a fluid to the tissue useful for enabling visual observation of the tissue.
claim 7
13. The catheter of , wherein the needle is constructed to apply a vacuum to the tissue.
claim 7
14. The catheter of , wherein the catheter shaft is constructed to be inserted through a working channel of an endoscope.
claim 11
15. The catheter of , wherein at least one of the optical fibers is further constructed for conveying visualization light to the tissue.
claim 1
16. The catheter of , wherein at least one of the optical fibers is further constructed for conveying light back from the tissue for visual observation of the tissue.
claim 1
17. A method of diagnosing and performing an interventional procedure on tissue, comprising the steps of: inserting into a lumen of a body of a living being a catheter having a first optical fiber for transmitting light to tissue located at a distal end of the catheter, a second optical fiber for conveying light back from the tissue for analysis by a spectroscopic diagnosis system, and an interventional device; transmitting light through the first optical fiber to tissue located at a distal end of the catheter; conveying light back from the tissue through the second optical fiber for analysis by a spectroscopic diagnosis system; diagnosing the tissue with the spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue; and engaging, with the interventional device, the tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue.
18. The method of , wherein the interventional procedure comprises marking the tissue by injecting a marking fluid into the tissue with the interventional device.
claim 17
19. The method of , wherein the marking fluid is india ink.
claim 18
20. The method of , further comprising the steps of:
claim 18
withdrawing the catheter having the optical fibers and the interventional device; inserting into the body of the living being a second catheter having a second interventional device located at its distal end; and engaging, with the second interventional device of the second catheter, the tissue diagnosed by the spectroscopic diagnosis system in order to perform another interventional procedure on the tissue.
21. The method of , wherein the step of diagnosing the tissue using the spectroscopic diagnosis system comprises determining whether an interventional procedure should be performed on the tissue.
claim 17
22. The method of , wherein the interventional procedure comprises removing tissue for biopsy analysis.
claim 17
23. The method of , wherein the interventional procedure comprises removing tissue diagnosed by the spectroscopic diagnosis system as being unhealthy.
claim 17
24. The method of , wherein the lumen comprises an alimentary lumen.
claim 17
25. The method of , wherein the lumen comprises a pulmonary lumen.
claim 17
26. The method of , wherein the step of diagnosing the tissue further comprises determining whether the tissue is a tumor.
claim 17
27. The method of , wherein the step of diagnosing the tissue further comprises determining whether the tumor is cancerous.
claim 26
28. The method of , further comprising the step of inserting through the lumen of the body of the living being an endoscope having a working channel, and wherein the step of inserting the catheter into the body of the living being comprises inserting the catheter into the working channel of the endoscope.
claim 17
29. The method of , further comprising the step of conveying visualization light to the tissue through at least one of the optical fibers.
claim 17
30. The method of , further comprising the step of conveying light back from the tissue through at least one of the optical fibers for visual observation of the tissue.
claim 17
31. The method of , further comprising the step of conveying a fluid through the catheter shaft to the tissue useful for enabling visual observation of the tissue.
claim 17
32. The method of , further comprising the step of applying a vacuum to the tissue through the catheter shaft.
claim 17
33. An assembly comprising:
an endoscope;
an elongated catheter shaft constructed to be inserted through a working channel of the endoscope;
an optical fiber, extending through the catheter shaft, for transmitting light to tissue located at a distal end of the catheter shaft;
an optical fiber, extending through the catheter shaft, for conveying light back from the tissue for-analysis by a spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue; and
an interventional device, constructed to be inserted through a working channel of the endoscope, for engaging tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue.
34. The assembly of wherein the interventional device is located at the distal end of the catheter shaft having the optical fibers.
claim 33
35. A method of diagnosing and performing an interventional procedure on tissue, comprising the steps of: inserting an endoscope through a lumen of a body of a living being; inserting through a working channel of the endoscope a catheter having a first optical fiber for transmitting light to tissue located at a distal end of the catheter and a second optical fiber for conveying light back from the tissue for analysis by a spectroscopic diagnosis system; transmitting light through the first optical fiber to tissue located at a distal end of the catheter; conveying light back from the tissue through the second optical fiber for analysis by a spectroscopic diagnosis system; diagnosing the tissue with the spectroscopic diagnosis system to determine whether an interventional procedure should be performed on the tissue; and engaging, with an interventional device inserted through a working channel of the endoscope, the tissue diagnosed by the spectroscopic diagnosis system in order to perform the interventional procedure on the tissue.
36. A method of imaging and performing an interventional procedure on tissue, comprising the steps of: inserting an endoscope through a lumen of a body of a living being;
inserting through a working channel of the endoscope a catheter having an ultrasound imaging device located at its distal end;
imaging a tissue structure located at a distal end of the endoscope with the ultrasound imaging device and displaying the tissue structure in a manner that indicates the depth of penetration of the tissue structure into the body of the living being; and
engaging, with an interventional device inserted through a working channel of the endoscope, the tissue structure imaged by the ultrasound imaging device in order to perform interventional therapy on the tissue structure, the interventional therapy being performed in a manner responsive to the displayed depth of penetration of the tissue structure.
37. The method of , wherein the interventional device is located at the distal end of an interventional catheter distinct from the catheter having the ultrasound device, there are at least two working channels of the endoscope, and the catheter having the ultrasound device is inserted through a first of the two working channels and the interventional catheter is inserted through a second of the two working channels.
claim 36
38. The method of , wherein the step of performing the interventional therapy in a manner responsive to the displayed depth of penetration of the tissue structure comprises determining whether the depth of penetration of the tissue structure is sufficiently limited such that the interventional therapy is justifiable and then, if the depth of penetration is sufficiently limited, performing the interventional therapy.
claim 36
39. The method of , wherein the step of performing the interventional therapy in a manner responsive to the displayed depth of penetration of the tissue structure comprises removing an amount of tissue corresponding to the depth of penetration.
claim 36
40. The method of , wherein the imaging step is performed simultaneously with the step of performing the interventional therapy.
claim 39
41. The method of , wherein the interventional device comprises a scalpel.
claim 36
42. The method of , wherein the interventional device comprises forceps jaws.
claim 36
43. The method of , wherein the interventional device comprises a snare.
claim 36
44. The method of , wherein the interventional device comprises a scissors.
claim 36
45. The method of , wherein the interventional device comprises a needle.
claim 36
46. The method of , wherein the step of engaging the tissue structure with the interventional device comprises injecting a chemical ablation fluid into the tissue through the needle.
claim 45
47. The method of , wherein the step of engaging the tissue structure with the interventional device comprises cutting the tissue with the needle.
claim 45
48. The method of , wherein the step of engaging the tissue structure with the interventional device comprises applying an adhesive material to the tissue using the needle.
claim 45
49. The method of , further comprising the step of transmitting light to the tissue structure, conveying light back from the tissue for analysis by a spectroscopic diagnosis system, and determining, using the spectroscopic diagnosis system, whether an interventional procedure should be performed on the tissue.
claim 36
50. The method of , wherein the lumen comprises an alimentary lumen.
claim 36
51. The method of , wherein the lumen comprises a pulmonary lumen.
claim 36
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US11/242,236 US8135454B2 (en) | 1996-07-08 | 2005-10-03 | Diagnosing and performing interventional procedures on tissue in vivo |
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Also Published As
Publication number | Publication date |
---|---|
DE69728277D1 (en) | 2004-04-29 |
CA2260147A1 (en) | 1998-01-15 |
US20060036182A1 (en) | 2006-02-16 |
US6296608B1 (en) | 2001-10-02 |
DE69728277T2 (en) | 2004-08-12 |
JP3943600B2 (en) | 2007-07-11 |
US8135454B2 (en) | 2012-03-13 |
EP0925034B1 (en) | 2004-03-24 |
JP2000516112A (en) | 2000-12-05 |
WO1998001074A1 (en) | 1998-01-15 |
EP0925034A1 (en) | 1999-06-30 |
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