EP2402427A3 - Sample block apparatus and method for retaining a microcard on a sample - Google Patents

Sample block apparatus and method for retaining a microcard on a sample Download PDF

Info

Publication number
EP2402427A3
EP2402427A3 EP11182817.4A EP11182817A EP2402427A3 EP 2402427 A3 EP2402427 A3 EP 2402427A3 EP 11182817 A EP11182817 A EP 11182817A EP 2402427 A3 EP2402427 A3 EP 2402427A3
Authority
EP
European Patent Office
Prior art keywords
sample block
microcard
sample
temperature
cycling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11182817.4A
Other languages
German (de)
French (fr)
Other versions
EP2402427A2 (en
Inventor
Adrian Fawcett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31186680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2402427(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Publication of EP2402427A2 publication Critical patent/EP2402427A2/en
Publication of EP2402427A3 publication Critical patent/EP2402427A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Abstract

A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface, may include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block, and a temperature control system operatively connected with the sample block. The upper surface may define a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. The temperature control system may be configured for cycling the sample block through a sequence of times and temperatures comprising at least a first temperature maintained for a first period of time and a second temperature maintained for a second period of time, with said second temperature being higher than said first temperature, and said cycling comprising at least two repetitions of said sequence of time and temperatures.
EP11182817.4A 2002-07-30 2003-07-30 Sample block apparatus and method for retaining a microcard on a sample Withdrawn EP2402427A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/207,263 US7452712B2 (en) 2002-07-30 2002-07-30 Sample block apparatus and method of maintaining a microcard on a sample block
EP10186424A EP2272944A1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for retaining a microcard on a sample
EP03795576A EP1539920B1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP03795576.2 Division 2003-07-30
EP10186424.7 Division 2010-10-04

Publications (2)

Publication Number Publication Date
EP2402427A2 EP2402427A2 (en) 2012-01-04
EP2402427A3 true EP2402427A3 (en) 2013-10-16

Family

ID=31186680

Family Applications (3)

Application Number Title Priority Date Filing Date
EP11182817.4A Withdrawn EP2402427A3 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for retaining a microcard on a sample
EP10186424A Withdrawn EP2272944A1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for retaining a microcard on a sample
EP03795576A Expired - Lifetime EP1539920B1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP10186424A Withdrawn EP2272944A1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for retaining a microcard on a sample
EP03795576A Expired - Lifetime EP1539920B1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block

Country Status (8)

Country Link
US (5) US7452712B2 (en)
EP (3) EP2402427A3 (en)
JP (1) JP2005534342A (en)
AT (1) ATE483790T1 (en)
AU (1) AU2003296707A1 (en)
CA (1) CA2493278A1 (en)
DE (1) DE60334465D1 (en)
WO (1) WO2004025247A2 (en)

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US7858365B2 (en) 2010-12-28
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US8247221B2 (en) 2012-08-21
US20130345097A1 (en) 2013-12-26
US20090029454A1 (en) 2009-01-29
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US7452712B2 (en) 2008-11-18
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